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Structural Elucidation And Toxicity Evaluation Of Bioactive Compounds From The Leaves And Stem Woods Of Synadenium Glaucescens Pax., David Credo, Faith Philemon Mabiki, Francis Machumi, Claus Cornett

Pharmaceutical Sciences and Research

The leaves and stem woods of Synadenium glaucescens Pax. are traditionally used for treatment of various human diseases in Tanzania. However, there is limited information on the structural elucidation and toxicity properties of bioactive compounds responsible for their pharmacological properties. Thus, this study was aimed to elucidate and evaluate toxicity properties of bioactive compounds from these parts. Separation of bioactive compounds was achieved by using column chromatographic method, whereas their structures were determined by GC-MS and NMR data and by comparing with literature spectroscopic data. Toxicity properties of isolated compounds was done by brine shrimp lethality test (BSLT) method. In …

Quantifying The Ecological Impacts Of Alien Aquatic Macrophytes: A Global Meta-Analysis Of Effects On Fish, Macroinvertebrate And Macrophyte Assemblages, Samuel J.L. Tasker, Andrew Foggo, David T. Bilton

School of Biological and Marine Sciences

1. Biological invasions constitute a pervasive and growing threat to the biodiversity and functioning of freshwater ecosystems. Macrophytes are key primary producers and ecosystem engineers in freshwaters, meaning that alien macrophyte invasions have the capacity to alter the structure and function of recipient aquatic ecosystems profoundly. Although prevailing wisdom holds that alien macrophyte invasions tend to compromise freshwater ecosystem structure and function, the ecological impacts of alien macrophyte invasion have not been quantitatively reviewed to date. 2. Here we present a global meta-analysis of 202 cases from 53 research articles, exploring the impacts of alien macrophyte invasion on the abundance …

Green Project Work For Process Writing Amidst The Pandemic: Planning, Implementing, And Reflections, Lestari Setyowati, Sari Karmina, Sony Sukmawan, Razlina Razali

Bahasa dan Seni: Jurnal Bahasa, Sastra, Seni, dan Pengajarannya

The aims of this paper are to discuss the concepts underlying Project-based learning (PjBL) and its syntax and to explore the planning, implementation, and reflection of PjBL in the online teaching of writing a process paragraph on the topic of using Reduce, Reuse, and Recycle (3R) principles to save the environment. Thirty-one students joined the paragraph writing course. The learning process and the students’ products of their projects were collected and documented in the form of videos, Power Point presentation, and electronic writing portfolios. The paper discusses how PjBl promotes collaborative work, problem-solving, critical thinking and technology integration. It also …

Interactive Software-Based Modeling For Gait Analysis Of Musculoskeletal Structures, Nada Masood Mirza, Adnan Ali, Mohamad Khairi Ishak

Makara Journal of Technology

Software for interactive musculoskeletal modeling applies diverse scientific and technological concepts to stimulate the movement of musculoskeletal figures. Several tools are available for biomechanical analysis in studying motion and capturing the musculoskeletal representation data to facilitate further evaluation for muscle activation. Musculoskeletal software, such as the OpenSim model, animates, and measures in 3D the structural movement of bones, muscles, joints, ligaments, and such structures in the human body. Users apply graphical interfaces to manipulate the movement science for fast and accurate analysis. OpenSim simulation software features a user-friendly interface to allow the proper clinical application in biomechanics and rehabilitation research. …

Ai Protein Structure Prediction-Based Modeling And Mutagenesis Of A Protostome Receptor And Peptide Ligands Reveal Key Residues For Their Interaction, Shi-Qi Guo, Ya-Dong Li, Ping Chen, Guo Zhang, Hui-Ying Wang, Hui-Min Jiang, Wei-Jia Liu, Ju-Ping Xu, Xue-Ying Ding, Ping Fu, Ke Yu, Hai-Bo Zhou, James W. Checco, Jian Jing

Department of Chemistry: Faculty Publications

The protostome leucokinin (LK) signaling system, including LK peptides and their G protein-coupled receptors, has been characterized in several species. Despite the progress, molecular mechanisms governing LK peptide–receptor interactions remain to be elucidated. Previously, we identified a precursor protein for Aplysia leucokinin-like peptides (ALKs) that contains the greatest number of amidated peptides among LK precursors in all species identified so far. Here, we identified the first ALK receptor from Aplysia, ALKR. We used cell-based IP1 activation assays to demonstrate that two ALK peptides with the most copies, ALK1 and ALK2, activated ALKR with high potencies. Other endogenous ALK-derived peptides …

Sustaining Indigenous Knowledge Through The Digitization Of Information On Herbal Medicine In Medical Libraries In Nigeria: Problems And Prospects., Emmanuel Chukwudi Ihekwoaba, Roseline Ngozi Okwor, Caroline Uchenna Nnadi, Uzoamaka Uzuoma Jidere, Ify Evangel Obim

Library Philosophy and Practice (e-journal)

This study examined the concept of herbal medicine and the need for supporting Indigenous knowledge through the digitalization of information on the accumulation and transmission of herbal healing practices from generation to generation. It examined the relevance of digitizing herbal medicine information in order to sustain and conserve this unique information. The digitalization of library health information also raises readers' attention. In addition, the organization is responsible for permanent storage and documentation of information resources, in particular health information. This research examined the strategic importance of medical libraries. It described how medical libraries could be crucial in digitizing indigenous herbal …

Blocking Chop-Dependent Txnip Shuttling To Mitochondria Attenuates Albuminuria And Mitigates Kidney Injury In Nephrotic Syndrome, Sun-Ji Park, Yeawon Kim, Chuang Li, Junwoo Suh, Jothilingam Sivapackiam, Tassia M Goncalves, George Jarad, Guoyan Zhao, Fumihiko Urano, Vijay Sharma, Ying Maggie Chen

2020-Current year OA Pubs

Albuminuria is a hallmark of glomerular disease of various etiologies. It is not only a symptom of glomerular disease but also a cause leading to glomerulosclerosis, interstitial fibrosis, and eventually, a decline in kidney function. The molecular mechanism underlying albuminuria-induced kidney injury remains poorly defined. In our genetic model of nephrotic syndrome (NS), we have identified CHOP (C/EBP homologous protein)-TXNIP (thioredoxin-interacting protein) as critical molecular linkers between albuminuria-induced ER dysfunction and mitochondria dyshomeostasis. TXNIP is a ubiquitously expressed redox protein that binds to and inhibits antioxidant enzyme, cytosolic thioredoxin 1 (Trx1), and mitochondrial Trx2. However, very little is known about …

Assist Conservation With Microbiome? An Investigation Using Native Amphibian Species In Hong Kong, Pui Yin Lam

Lingnan Theses (MPhil & PhD)

Microorganisms often have a negative connotation of disease, especially during the recent COVID-19 pandemic. However, many microorganisms are essential to health, from assisting nutrient acquisition to providing insights in advanced medicine. The diverse microorganisms (including bacteria, viruses, fungi, archaea, and protozoans) inhabiting a host are collectively known as the “microbiota”. The importance of microbiota is not limited to humans, but also applies to wildlife. Recent research highlighted the tremendous potential of applying microbiota research to wildlife conservation, such as understanding host’s health in relation to anthropogenic effects. Amphibians, being one of the most diverse but threatened groups of vertebrates, are …

Contrasting Effects Of Sleep Fragmentation And Angiotensin-Ii Treatment Upon Pro-Inflammatory Responses Of Mice, David C. Ensminger, Nicholas D. Wheeler, Reem Al Makki, Kristen N. Eads, Noah T. Ashley

Faculty Research, Scholarly, and Creative Activity

Disordered sleep promotes inflammation in brain and peripheral tissues, but the mechanisms that regulate these responses are poorly understood. One hypothesis is that activation of the sympathetic nervous system (SNS) from sleep loss elevates blood pressure to promote vascular sheer stress leading to inflammation. As catecholamines produced from SNS activation can directly regulate inflammation, we pharmacologically altered blood pressure using an alternative approach-manipulation of the renin-angiotensin system (RAS). Male C57BL6/J mice were treated with angiotensin or captopril to elevate and reduce blood pressure, respectively and then exposed to 24-h of sleep fragmentation (SF) or allowed to sleep (control). Pro- and …

Evidence Based Practice: Assessing The Educational Outcome, Michelle Brady Dr., Des Gallagher

Pacific Journal of Health

Healthcare providers and patients strive for optimal outcomes with a growing trend to embed the principles of evidence-based practice (EBP) into mainstream care delivery by practicing dentists. The foundations of future best practice are built at dental school. How do we evaluate the outcome of an EBP syllabus?

This study describes the use of the KACE assessment tool to assess the learning outcomes of final year DDS students who had completed an EBP program. The use of a validated instrument to measure four dimensions, knowledge, attitudes about it, familiarity with sources for accessing evidence and confidence in critical appraisal skills …

Where Kindness Is Calculated: Refugee Regimes In South Asia, Shuvro Prosun Sarker, Shreyasi Bhattacharya

Indonesian Journal of International Law

South Asia, as part of SAARC treaty, comprising of nations such as Afghanistan, Bangladesh, Bhutan, India, Maldives, Nepal, Pakistan and Sri Lanka is not a part of any common system of governance in protecting refugee. These nations have developed their own preference of protection through their practices coupled with mysterious unwillingness to accept international obligations and responsibilities while choosing certain refugee groups to welcome and certain to refuse. Based on this, the article starts with the proposition that this kind of a preferential protection practice that these States have adopted largely, refers to a regime of calculated kindness that …

Traditional Knowledge And Twail, Gunjan Deshpande

Indonesian Journal of International Law

Traditional Knowledge (TK) is a deep-rooted notion in the Indian culture, it is the knowledge that has been passed on for centuries and is governed by the traditional customary laws. It applies to everything from food storage, agriculture to medicine to the preservation of the environment. TK are protected by national or regional laws that provide limited protection. There have been various instances where Indian TK was patented outside India some of the examples are Turmeric, Amla, and Neem. TK is the base of modern science and technology, as it is derived from a strong cultural heritage that is vital …

What’S In Your Glass? Whether Milk Labels Should Be Based On Creation Process Or End Product (Part Iii Of Iii), Samantha Masters

Law Review Blog Posts

Part III of this blog series proposes a three-part solution to the debate over labeling cultured milk that promotes consumer clarity, marketability, and judicial efficiency.

Lgbtq+ In The Cowl: The Good, The Bad, The Ugly - Tracing Coverage Of Lgbtq+ Topics From 1935 To 2022, Nicole Patano

Sociology & Anthropology Student Scholarship

In their very first issue published on November 16, 1935, The Cowl staff explained the purpose of the novel student newspaper: “Primarily, the COWL exists to serve the student body, not simply as a news organ, but more fundamentally as a means to foster and intensify an enthusiatic Providence College spirit and loyalty.” Since its founding, The Cowl has attempted to be just that, reporting news and welcoming discussion and debate from members of its staff and members of the larger Providence College community.

Unfortunately, however, the mission of the College can, and often has, run contrary to the mission …

The Rider (2022-08-29), Verilu Infante

The Rider Archives

Vol.8 No.1

20220829_Meet Our Students Monday, Amy Weig-Pickering

HSLIC Blog Post

No abstract provided.

More Work, Less Reward: The Minority Tax On Us Medical Students, Marija Kamceva, Baffour Kyerematen, Sabina Spigner, Samuel Bunting, Simiao Li-Sauerwine, Jane Yee, Michael Gisondi

Journal of Wellness

Introduction: Minority tax is defined as the burden of time and resources placed on minority persons to represent and advocate for their communities. We determined whether medical students underrepresented in medicine (URM) or from historically excluded (HE) populations experience a minority tax and characterized its effects.

Methods: This cross-sectional survey of US medical students occurred November 2020 - June 2021. We used Mann-Whitney U tests to compare metrics between URM and HE participants and their peers. The primary outcome was time invested in activism/diversity initiatives versus other work. Secondary outcomes included measures of microaggressions, discrimination, institutional culture, anxiety/depression, …

Mmu: 08/29/22–09/04/22, Student Bar Association

Monday Morning Update

This Week @ NDLS

Mass Times

Commons Daily Menu

General Announcements

1L of the Week: Sudeep Kalkunte

2Ls Taking Ls: Lizzy Forzley

Ask a 3L: Matteo Taraborrelli

Sport Report by Stephen Nugent

Jackie's Corner

Wild Roots: Ginseng, Conservation, And Nature In The Appalachian South, Katherine Farley

Arts & Sciences Graduate Student Theses and Dissertations

American ginseng (Panax quinquefolius L.) is a medicinal plant native to eastern North America. Though the plant has a history of Indigenous use, wild American ginseng roots have been commercially harvested, primarily for export to east Asia, since the 18th century. There is a long history of harvesting ginseng in Appalachia as a source of supplementary income, as living-wage jobs in the region have historically been scarce. Today, harvesters can make hundreds of dollars per pound of dried, wild-harvested American ginseng roots. However, ginseng populations in the wild today are thought to be substantially smaller than their historical peak, which …

Host Species And Captivity Distinguish The Microbiome Compositions Of A Diverse Zoo-Resident Non-Human Primate Population, Maya O. Wills, Robin R. Shields-Cutler, Emily Brunmeier, Madison Weissenborn, Tami Murphy, Dan Knights, Timothy J. Johnson, Jonathan B. Clayton

Department of Food Science and Technology: Faculty Publications

Vast numbers of microorganisms inhabit the mammalian gastrointestinal tract in a complex community referred to as the gut microbiome. An individual’s microbiome may be impacted by genetics, diet, and various environmental factors, and has been associated with many health states and diseases, though specific explanations are lacking. While these communities are well-studied in human populations, non-human primates (NHPs), in particular zoo-resident or captive NHPs, offer distinct advantages to increasing our understanding of factors that influence gut microbiome composition. Here, we characterize the gut microbiome composition of a phylogenetically diverse cohort of NHPs residing in the same urban zoo. We show …

Comorbidity Of Novel Crhr2 Gene Variants In Type 2 Diabetes And Depression, Mutaz Amin, Jurg Ott, Derek Gordon, Rongling Wu, Teodor T Postolache, Michael Vergare, Claudia Gragnoli

Department of Psychiatry and Human Behavior Faculty Papers

The corticotropin-releasing hormone receptor 2 (CRHR2) gene encodes CRHR2, contributing to the hypothalamic-pituitary-adrenal stress response and to hyperglycemia and insulin resistance. CRHR2-/- mice are hypersensitive to stress, and the CRHR2 locus has been linked to type 2 diabetes and depression. While CRHR2 variants confer risk for mood disorders, MDD, and type 2 diabetes, they have not been investigated in familial T2D and MDD. In 212 Italian families with type 2 diabetes and depression, we tested 17 CRHR2 single nucleotide polymorphisms (SNPs), using two-point parametric-linkage and linkage-disequilibrium (i.e., association) analysis (models: dominant-complete-penetrance-D1, dominant-incomplete-penetrance-D2, recessive-complete-penetrance-R1, recessive-incomplete-penetrance-R2). We detected novel linkage/linkage-disequilibrium/association …

#Golead Newsletter, Georgia Southern University

#GoLead Newsletter (2016-2023)

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Friendly But Faulty: A Pilot Study On The Perceived Trust Of Older Adults In A Social Robot, Ioanna Giorgi, Francesca Tirotto, Oksana Hagen, Farida Aider, Mario Gianni, Marco Palomino, Giovanni L. Masala

School of Engineering, Computing and Mathematics

No abstract provided.

Increased Extent Of Waterfowl Grazing Lengthens The Recovery Time Of A Colonizing Seagrass (Halophila Ovalis) With Implications For Seagrass Resilience, Caitlyn M. O’Dea, Paul S. Lavery, Chanelle L. Webster, Kathryn M. Mcmahon

Research outputs 2022 to 2026

Herbivore distributions and abundance are shifting because of climate change, leading to intensified grazing pressure on foundation species such as seagrasses. This, combined with rapidly increasing magnitudes of change in estuarine ecosystems, may affect seagrass resilience. While the overall resilience of seagrasses is generally well-studied, the timeframes of recovery has received comparatively little attention, particularly in temperate estuaries. We investigated how the recovery time (RT) of seagrass is affected by simulated grazing in a southwestern Australian estuary. Whilst excluding swans, we simulated different grazing intensities (25, 50, 75, and 100 % removal from 1 m2 plots) at four locations in …

The Impacts Of Shariah-Compliant Hotel Attributes On Muslim Travellers Revisit Intention: Religiosity As A Moderator, Zaidatul Akma Sulaiman, Mohammad Iranmanesh, Behzad Foroughi, Othman Rosly

Research outputs 2014 to 2021

Purpose: This paper aims to investigate the impact of Shariah-compliant hotel attributes on Muslim travellers’ revisit intention.

Design/methodology/approach: A total of 361 Muslim travellers who have stayed at Shariah-compliant hotels in the previous 12 months were recruited to take part in this research. The hypothesized research model was assessed using the partial least squares (PLS) approach.

Findings: The analysis revealed that Muslim travellers’ revisit intention is dependent on the halal food and beverages and the provision of Shariah-compliant facilities at the hotel, whereas the Shariah-compliant operation and interior design of hotels are not significantly associated with it. The findings also …

Travel Medicine, Somchai Bovornkitti

Asian Medical Journal and Alternative Medicine

No abstract provided.

Herbaceous Production Lost To Tree Encroachment In United States Rangelands, Scott L. Morford, Brady W. Allred, Dirac L. Twidwell Jr, Matthew O. Jones, Jeremy D. Maestas, Caleb P. Roberts, David E. Naugle

Department of Agronomy and Horticulture: Faculty Publications

1. Rangelands of the United States provide ecosystem services that benefit society and rural economies. Native tree encroachment is often overlooked as a primary threat to rangelands due to the slow pace of tree cover expansion and the positive public perception of trees. Still, tree encroachment fragments these landscapes and reduces herbaceous production, thereby threatening habitat quality for grassland wildlife and the economic sustainability of animal agriculture.

2. Recent innovations in satellite remote sensing permit the tracking of tree encroachment and the corresponding impact on herbaceous production. We analysed tree cover change and herbaceous production across the western United States …

Epithelial Immunomodulation By Aerosolized Toll-Like Receptor Agonists Prevents Allergic Inflammation In Airway Mucosa In Mice, David L. Goldblatt, Gabriella Valverde Ha, Shradha Wali, Vikram V. Kulkarni, Michael K. Longmire, Ana M. Jaramillo, Rosha P. Chittuluru, Adrienne Fouts, Margarita Martinez-Moczygemba, Jonathan T. Lei

School of Medicine Publications

Allergic asthma is a chronic inflammatory respiratory disease associated with eosinophilic infiltration, increased mucus production, airway hyperresponsiveness, and airway remodeling. Epidemiologic data reveal that the prevalence of allergic sensitization and associated diseases has increased in the twentieth century. This has been hypothesized to be partly due to reduced contact with microbial organisms (the hygiene hypothesis) in industrialized society. Airway epithelial cells, once considered a static physical barrier between the body and the external world, are now widely recognized as immunologically active cells that can initiate, maintain, and restrain inflammatory responses, such as those that mediate allergic disease. Airway epithelial cells …

In Silico And In Vitro Studies Of Taiwan Chingguan Yihau (Nricm101) On Tnf-Α/Il-1Β-Induced Human Lung Cells, Yih-Dih Cheng, Chi‑Cheng Lu, Yuan-Man Hsu, Fuu-Jen Tsai, Da-Tian Bau, Shih-Chang Tsai, Ching-Chang Cheng, Jen-Jyh Lin, Yuang-Yu Huang, Yu-Ning Juan, Yu-Jen Chiu, Sheng-Chu Kuo, Jai-Sing Yang, Lii-Tzu Wu

BioMedicine

COVID-19 pandemic has been a global outbreak of coronavirus (SARS-CoV-2 virus) since 2019. Taiwan Chingguan Yihau (NRICM101) is the first traditional Chinese medicine (TCM) classic herbal formula and is widely used for COVID-19 patients in Taiwan and more than 50 nations. This study is to investigate in silico target fishing for the components of NRICM101 and to explore whether NRICM101 inhibits cytokines-induced normal human lung cell injury in vitro. Our results showed that network prediction of NRICM101 by a high throughput target screening platform showed that NRICM101 has multiple functions that may affect cytokine regulation to prevent human lung cell …

Ethanol Leaf Extract Of Hoslundia Opposita In In Vivo Antioxidant And Hepatoprotective Activity Using An Animal Model, Fred Coolborn Akharaiyi, Odoligie Imarhiagbe, Lucky Efe Isunu, Adebayo Thomas Ajibola

BioMedicine

Introduction and aim: The liver is a useful organ that is responsible for the detoxification of harmful substances from the body. Its vital role is of importance hence it should be protected from damages in order to function normally. The management of liver diseases with orthodox medicine has been found to have side effects thus its effective management with folklore has been found better.

Materials and Methods: The leaves of H. oppisota harvested from a forest was processed and extracted with ethanol. The extract concentrations of 100 to 400 mg/ml was used to evaluate acute toxicity, biochemical analysis, …