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2022

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High Power Microwave Operational Exposure Detection Using Thermoacoustic Wave Generation In Lossy Dielectric Polymers, James J. Frey Sep 2022

High Power Microwave Operational Exposure Detection Using Thermoacoustic Wave Generation In Lossy Dielectric Polymers, James J. Frey

Theses and Dissertations

A feasibility analysis for the use of microwave-induced thermoacoustic (TA) wave generation in lossy dielectric media to detect pulsed high power microwave directed energy weapons in force health protection applications was conducted based on a series of empirical and computational investigations. A potential target volume material, carbon-loaded polytetrafluoroethylene, was identified for further study based on anticipated complex dielectric properties, with laboratory measurements of select electromagnetic (EM), thermal, and elastic material properties of relevance to the TA effect conducted to determine parameter values. A planar geometry TA-based signal chain model using thin film piezoelectric sensors was developed for both finite element …


Eeg-Video Emotion-Based Summarization: Learning With Eeg Auxiliary Signals, Wai-Cheong L. Lew, Di Wang, Kai Keng Ang, Joo-Hwee Lim, Chai Quek, Ah-Hwee Tan Sep 2022

Eeg-Video Emotion-Based Summarization: Learning With Eeg Auxiliary Signals, Wai-Cheong L. Lew, Di Wang, Kai Keng Ang, Joo-Hwee Lim, Chai Quek, Ah-Hwee Tan

Research Collection School Of Computing and Information Systems

Video summarization is the process of selecting a subset of informative keyframes to expedite storytelling with limited loss of information. In this paper, we propose an EEG-Video Emotion-based Summarization (EVES) model based on a multimodal deep reinforcement learning (DRL) architecture that leverages neural signals to learn visual interestingness to produce quantitatively and qualitatively better video summaries. As such, EVES does not learn from the expensive human annotations but the multimodal signals. Furthermore, to ensure the temporal alignment and minimize the modality gap between the visual and EEG modalities, we introduce a Time Synchronization Module (TSM) that uses an attention mechanism …


Long Nineteenth Century Ephemera, J Gregory Sep 2022

Long Nineteenth Century Ephemera, J Gregory

School of Law, Humanities and Social Sciences

No abstract provided.


Untold Story Of Human Cervical Cancers: Hpv-Negative Cervical Cancer, Jae-Eun Lee, Yein Chung, Siyeon Rhee, Tae-Hyung Kim Sep 2022

Untold Story Of Human Cervical Cancers: Hpv-Negative Cervical Cancer, Jae-Eun Lee, Yein Chung, Siyeon Rhee, Tae-Hyung Kim

Pathology Research and Scholarship

Cervical cancer is the fourth most common malignancy in women worldwide. Although infection from human papillomavirus (HPV) has been the leading cause of cervical cancer, HPV-negative cervical cancer accounts for approximately 3-8% of all cases. Previous research studies on cervical cancer have focused on HPV-positive cervical cancer due to its prevalence, resulting in HPV-negative cervical cancer receiving considerably less attention. As a result, HPV-negative cervical cancer is poorly understood. Its etiology remains elusive mainly due to limitations in research methodology such as lack of defined markers and model systems. Moreover, false HPV negativity can arise from inaccurate diagnostic methods, which …


Tennessee Farm Bureau News - September 2022, Tennessee Farm Bureau Federation Sep 2022

Tennessee Farm Bureau News - September 2022, Tennessee Farm Bureau Federation

Tennessee Farm Bureau News

No abstract provided.


A Systematic Review: The Source Of Antimicrobial Resistance Pathogenic Bacteria On Slaughtered Meat, Cross-Contamination Or Self-Contamination?, Xin Wu, Fanan Suksawat, Sunpetch Angkititrakul, Chunlian Song, Jun Chai, Yifang Zhang, Xianghua Shu, Huiyan Xing, Wengui Li Sep 2022

A Systematic Review: The Source Of Antimicrobial Resistance Pathogenic Bacteria On Slaughtered Meat, Cross-Contamination Or Self-Contamination?, Xin Wu, Fanan Suksawat, Sunpetch Angkititrakul, Chunlian Song, Jun Chai, Yifang Zhang, Xianghua Shu, Huiyan Xing, Wengui Li

The Thai Journal of Veterinary Medicine

Slaughtered meat has been identified as one of the major vehicles for forming antimicrobial resistance (AMR). It is still believed that AMR pathogens introduced by overusing antimicrobials in the breeding industry are directly brought in from farm animals. This disregards however the fact that many gut pathogens do not settle on muscle parts; the presence of gut pathogens on muscle products does not directly correlate to farm feeding. To investigate whether the source of AMR bacteria on slaughtered meat was cross-contamination or self-contamination, many peer-reviewed publications were studied to assess if the observational studies focused on AMR pathogenic bacteria association …


Application Of A Single-Tank Sequencing Batch Reactor For Long-Term Zebrafish Care, Aranya Ponpornpisit, Malinee Jongjaroenjai, Naowarat Suthamnatpong, Surachet Burut-Archanai Sep 2022

Application Of A Single-Tank Sequencing Batch Reactor For Long-Term Zebrafish Care, Aranya Ponpornpisit, Malinee Jongjaroenjai, Naowarat Suthamnatpong, Surachet Burut-Archanai

The Thai Journal of Veterinary Medicine

Sequencing batch reactors are efficient wastewater treatment systems, however, they are not adapted to treat aquaria. We aimed to compare the efficacies of a modified single-tank sequencing batch reactor (SSBR) and a regular overflow filtration system. Zebrafish were maintained in an acrylic aquarium connected to an SSBR or in a tank connected to a regular overflow filtration system for 27 weeks. Water change or aeration using air stone was not performed. The water quality in both groups was within the normal range until 26 weeks, after which the nitrite and nitrate levels increased. The average temperature was, 29.46 ± 0.71°C …


Haplotype Variation Of Partial Sry Gene In Ongole Grade Bulls (Bos Indicus) Of Indonesia, Widya Pintaka Bayu Putra, Saiful Anwar, Slamet Diah Volkandari, Syahruddin Said Sep 2022

Haplotype Variation Of Partial Sry Gene In Ongole Grade Bulls (Bos Indicus) Of Indonesia, Widya Pintaka Bayu Putra, Saiful Anwar, Slamet Diah Volkandari, Syahruddin Said

The Thai Journal of Veterinary Medicine

Ongole grade cattle (Bos indicus) are Indonesian beef cattle that adapt well in a tropical climate. This study was aimed to observe the genetic diversity of partial Sex-determining of the region Y chromosome (SRY) gene (625 bp) in Ongole grade bulls (Bos indicus) of Indonesia. A total twenty-three (23) DNA samples of animal studies were collected from frozen sperm (straws) produced by the National Artificial Insemination Centers (NAICs) of Lembang (13 straws) and Singosari (10 straws). Research showed that a total of four (4) insertion mutations were detected in the intronic region with the position of 1831th, 1844th, 1850th and …


Environmental Enrichment And The Behavioral Effects On Captive Beluga Whales (Delphinapterus Leucas), Tsung-Hsien Li, Evonne Lim, I-Chun Chen, Chuen-Fu Lin, Shih-Chu Chen, Ming-An Tsai Sep 2022

Environmental Enrichment And The Behavioral Effects On Captive Beluga Whales (Delphinapterus Leucas), Tsung-Hsien Li, Evonne Lim, I-Chun Chen, Chuen-Fu Lin, Shih-Chu Chen, Ming-An Tsai

The Thai Journal of Veterinary Medicine

Environmental enrichment methods are meant to encourage animals to display their complete ethogram while under human care in zoos and aquariums. In this study, we sought to characterize the effectiveness of environmental enrichment (involving the inclusion of toys in the living environment) on captive beluga whales in the National Museum of Marine Biology and Aquarium. Our results indicate that belugas with toys spend less time floating and swimming repetitively than do belugas without toys. The presence of toys was also shown to enhance social interactions among captive belugas. Overall, our findings indicate that the provision of toys can enrich the …


Efficacy And Safety Of Acupuncture And Or Moxibustion For Managing Primary Dysmenorrhea: A Systematic Review And Meta-Analysis, Weiting Liu, Carol Chunfeng Wang, Khui Hung Lee, Xiaopeng Ma, Timothy Leen Kang Sep 2022

Efficacy And Safety Of Acupuncture And Or Moxibustion For Managing Primary Dysmenorrhea: A Systematic Review And Meta-Analysis, Weiting Liu, Carol Chunfeng Wang, Khui Hung Lee, Xiaopeng Ma, Timothy Leen Kang

Research outputs 2022 to 2026

Acupuncture and moxibustion have been accepted as add-on options for primary dysmenorrhea (PD); however, the clinical evidence is still inadequate. We searched AMED, CENTRAL, EMBASE, PubMed, Web of Science, CBM, CNKI, VIP, Wangfang database, ANZCTR, ClinicalTrials.gov, and the WHO ICTRP, from their inception to February 2021. The pooled analysis of 13 RCTs with 675 participants for VAS showed that acupuncture and moxibustion were more effective in managing PD than the control group with the MD of −1.93 (95% CI [−2.80, −1.06] and −2.67 (95% CI [−4.96, −0.38]). With the CMSS, seven studies with 487 participants showed that these modalities were …


Regeneration Time: Ancient Wisdom For Planetary Wellbeing, Anne Poelina, Sandra Wooltorton, Mindy Blaise, Catrina Luz Aniere, Pierre Horwitz, Peta J. White, Stephen Muecke Sep 2022

Regeneration Time: Ancient Wisdom For Planetary Wellbeing, Anne Poelina, Sandra Wooltorton, Mindy Blaise, Catrina Luz Aniere, Pierre Horwitz, Peta J. White, Stephen Muecke

Research outputs 2022 to 2026

In these regenerative times prompted by the Anthropocene, Aboriginal voices are situated to draw on ancient wisdom for local learning and to share information across the globe as ecological imperative for planetary wellbeing. In this paper, postqualitative research foregrounds the sentient nature of life as ancestral power and brings the vitality of co-becoming as our places into active engagement. It enables coloniality to surface and reveals how it sits in our places and lives, in plain sight but unnoticed because of its so-called common sense. Postqualitative research relates with ancient knowledges in foregrounding Country's animacy and presence, revealing the essence …


‘Fly-Ing’ From Rare To Common Neurodegenerative Disease Mechanisms, Mengqi Ma, Matthew J Moulton, Shenzhao Lu, Hugo J Bellen Sep 2022

‘Fly-Ing’ From Rare To Common Neurodegenerative Disease Mechanisms, Mengqi Ma, Matthew J Moulton, Shenzhao Lu, Hugo J Bellen

Duncan NRI Faculty and Staff Publications

Genome sequencing advances have enabled researchers and clinicians to probe vast numbers of human variants to distinguish pathogenic from benign variation. Model organisms have been critical in variant assessment and delineating molecular mechanisms of some of the diseases caused by these variants. The fruit fly, Drosophila melanogaster, has played a valuable role in this endeavor, taking advantage of its genetic technologies and established biological knowledge. In this review, we highlight the utility of the fly in studying the function of genes associated with rare neurological diseases that have led to a better understanding of common disease mechanisms. We emphasize …


Kctd7 Deficiency Induces Myoclonic Seizures Associated With Purkinje Cell Death And Microvascular Defects, Justine H Liang, Jonathan Alevy, Viktor Akhanov, Ryan Seo, Cory A Massey, Danye Jiang, Joy Zhou, Roy V Sillitoe, Jeffrey L Noebels, Melanie A Samuel Sep 2022

Kctd7 Deficiency Induces Myoclonic Seizures Associated With Purkinje Cell Death And Microvascular Defects, Justine H Liang, Jonathan Alevy, Viktor Akhanov, Ryan Seo, Cory A Massey, Danye Jiang, Joy Zhou, Roy V Sillitoe, Jeffrey L Noebels, Melanie A Samuel

Duncan NRI Faculty and Staff Publications

Mutations in the potassium channel tetramerization domain-containing 7 (KCTD7) gene are associated with a severe neurodegenerative phenotype characterized by childhood onset of progressive and intractable myoclonic seizures accompanied by developmental regression. KCTD7-driven disease is part of a large family of progressive myoclonic epilepsy syndromes displaying a broad spectrum of clinical severity. Animal models of KCTD7-related disease are lacking, and little is known regarding how KCTD7 protein defects lead to epilepsy and cognitive dysfunction. We characterized Kctd7 expression patterns in the mouse brain during development and show that it is selectively enriched in specific regions as the brain matures. We further …


Patterns Of Diurnal And Nocturnal Cub-Directed Social Interaction And Guarding Behaviour In Sumatran Tigers, Gq Pastorino, C Dougal, K Sanders, T Stubbington, Je Brereton, R Preziosi Sep 2022

Patterns Of Diurnal And Nocturnal Cub-Directed Social Interaction And Guarding Behaviour In Sumatran Tigers, Gq Pastorino, C Dougal, K Sanders, T Stubbington, Je Brereton, R Preziosi

School of Biological and Marine Sciences

Felids are commonly housed in zoological collections worldwide. While aspects of their behaviour are well studied, there remain questions on best practice husbandry including during reproduction and breeding scenarios. In 2016, the Zoological Society of London’s (ZSL) London Zoo held a pair of Sumatran tigers (Panthera tigris sumatrae) for the purpose of breeding. While they are believed to be solitary in the wild, many collections maintain their tigers in pairs, with some keeping pairs together during parturition and rearing periods. The aim of this study was to investigate the social interactions between a male Sumatran tiger and cubs when housed …


Methylation-Mediated Silencing Of Ptprd Induces Pulmonary Hypertension By Promoting Pulmonary Arterial Smooth Muscle Cell Migration Via The Pdgfrb/Plcγ1 Axis, Junhua Xu, Yanfeng Zhong, Haoyang Yin, John Linneman, Yixuan Luo, Sijian Xia, Qinyi Xia, Lei Yang, Xingtao Huang, Kang Kang, Jun Wang, Yanqin Niu, Li Li, Deming Gou Sep 2022

Methylation-Mediated Silencing Of Ptprd Induces Pulmonary Hypertension By Promoting Pulmonary Arterial Smooth Muscle Cell Migration Via The Pdgfrb/Plcγ1 Axis, Junhua Xu, Yanfeng Zhong, Haoyang Yin, John Linneman, Yixuan Luo, Sijian Xia, Qinyi Xia, Lei Yang, Xingtao Huang, Kang Kang, Jun Wang, Yanqin Niu, Li Li, Deming Gou

2020-Current year OA Pubs

OBJECTIVE: Pulmonary hypertension is a lethal disease characterized by pulmonary vascular remodeling and is mediated by abnormal proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs). Platelet-derived growth factor BB (PDGF-BB) is the most potent mitogen for PASMCs and is involved in vascular remodeling in pulmonary hypertension development. Therefore, the objective of our study is to identify novel mechanisms underlying vascular remodeling in pulmonary hypertension.

METHODS: We explored the effects and mechanisms of PTPRD downregulation in PASMCs and PTPRD knockdown rats in pulmonary hypertension induced by hypoxia.

RESULTS: We demonstrated that PTPRD is dramatically downregulated in PDGF-BB-treated PASMCs, pulmonary …


Mild Hypothermia Fails To Protect Infant Macaques From Brain Injury Caused By Prolonged Exposure To Antiseizure Drugs, Chrysanthy Ikonomidou, Sophie H Wang, Nicole A Fuhler, Shreya Larson, Saverio Capuano 3rd, Kevin R Brunner, Kristin Crosno, Heather A Simmons, Andres F Mejia, Kevin K Noguchi Sep 2022

Mild Hypothermia Fails To Protect Infant Macaques From Brain Injury Caused By Prolonged Exposure To Antiseizure Drugs, Chrysanthy Ikonomidou, Sophie H Wang, Nicole A Fuhler, Shreya Larson, Saverio Capuano 3rd, Kevin R Brunner, Kristin Crosno, Heather A Simmons, Andres F Mejia, Kevin K Noguchi

2020-Current year OA Pubs

Barbiturates and benzodiazepines are GABA


Anatomical Analysis Of Inferior Alveolar Nerve Relation To Mandibular Posterior Teeth Using Cone Beam Computed Tomography: A Retrospective Radiographic Analysis Study, Shehabeldin Mohamed Saber Prof.Dr. Sep 2022

Anatomical Analysis Of Inferior Alveolar Nerve Relation To Mandibular Posterior Teeth Using Cone Beam Computed Tomography: A Retrospective Radiographic Analysis Study, Shehabeldin Mohamed Saber Prof.Dr.

Dentistry

Introduction: Cone beam computed tomography (CBCT) is reliable in the assessment of structures related to teeth. The assessment of the inferior alveolar neurovascular (IAN) bundle location using CBCT is considered one of its prime uses in different mandibular surgeries. Methodology: Retrospective CBCT data of patients presented to the institute were assessed to measure relations of IAN. Measurements were taken to assess the bone thickness adjacent to IAN, the superior-inferior dimension between the canal and the teeth, and the dimension between the canal and the inferior border of the mandible. Results: Out of the 170 patients the root apices nearest to …


Evaluation Of A Threonine Fermentation Product As A Digestible Threonine Source In Broilers, D. T. Lee, J. T. Lee, A. J. Ashworth, M. T. Kidd, A. Mauromostakos, S. J. Rochell Sep 2022

Evaluation Of A Threonine Fermentation Product As A Digestible Threonine Source In Broilers, D. T. Lee, J. T. Lee, A. J. Ashworth, M. T. Kidd, A. Mauromostakos, S. J. Rochell

Poultry Science Faculty Publications and Presentations

In the present experiment, a Thr fermentation product (FP) (75% minimum digestible Thr) was evaluated as a replacement for crystalline L-Thr (98.5% minimum digestible Thr) as a source of digestible Thr and other nutrients to support broiler performance (0–48 d) and processing characteristics. Five phase-fed diets included 1) a positive control (PC) diet containing L-Met, L-Lys•HCl, and L-Thr, 2) a reduced protein control (RPC) diet with added L-Val, L-Ile, and L-Arg, 3) a negative control (NC) identical to the RPC except that cellulose was added at the expense of L-Thr, 4) a …


Kenyon Collegian - September 1, 2022 Sep 2022

Kenyon Collegian - September 1, 2022

The Kenyon Collegian

No abstract provided.


Strengthening The Procedural Fidelity Research-To-Practice Loop In Animal Behavior, Tiffany Kodak, Samantha Bergmann, Mindy Waite Sep 2022

Strengthening The Procedural Fidelity Research-To-Practice Loop In Animal Behavior, Tiffany Kodak, Samantha Bergmann, Mindy Waite

Psychology Faculty Research and Publications

Procedural fidelity is the extent to which components of an intervention are implemented as designed. Procedural fidelity is measured as a dependent variable and manipulated as an independent variable. In research and practice, procedural-fidelity data should be collected, monitored, and reported. Procedural fidelity as an independent variable has been investigated in humans using parametric analyses, and the current article summarizes some of the research conducted on the effects of procedural-fidelity errors in behavior-reduction and skill-acquisition interventions. Connections were drawn to applied animal researchers and the work of animal behavior practitioners to produce implications for practice with human and animal clients …


Remodeling Of The Cortical Structure Connectome In Posttraumatic Stress Disorder: Results From The Enigma-Pgc Posttraumatic Stress Disorder Consortium, Jacklynn M. Fitzgerald Sep 2022

Remodeling Of The Cortical Structure Connectome In Posttraumatic Stress Disorder: Results From The Enigma-Pgc Posttraumatic Stress Disorder Consortium, Jacklynn M. Fitzgerald

Psychology Faculty Research and Publications

Background

Posttraumatic Stress Disorder (PTSD) is accompanied by disrupted cortical neuroanatomy. We investigated alteration in covariance of structural networks associated with PTSD in regions that demonstrate the case-control differences in cortical thickness (CT) and surface area (SA).

Methods

Neuroimaging and clinical data were aggregated from 29 research sites in >1300 PTSD cases and >2000 trauma-exposed control subjects (ages 6.2-85.2 years) by the ENIGMA-PGC (Enhancing Neuro Imaging Genetics through Meta Analysis-Psychiatric Genomics Consortium) PTSD working group. Cortical regions in the network were rank ordered by the effect size of PTSD-related cortical differences in CT and SA. The top-n (n …


A Rare Case Of Vulvar Discharge Associated With Exogenous Oestrogen Exposure In A Spayed Weimaraner Bitch, Francesca Ivaldi, Camille Ogdon, Firdous A Khan Sep 2022

A Rare Case Of Vulvar Discharge Associated With Exogenous Oestrogen Exposure In A Spayed Weimaraner Bitch, Francesca Ivaldi, Camille Ogdon, Firdous A Khan

Faculty, Staff and Students Publications

OBJECTIVE: This report documents a rare case of vulvar discharge associated with exogenous oestrogen exposure in a large-breed dog.

CASE DESCRIPTION: A 4-year-old spayed Weimaraner bitch was presented for evaluation of inappetence and intermittent sanguineous vulvar discharge. Physical examination, vaginal cytology, haematological, and ultrasonographic findings were indicative of a uterine stump pyometra. A celiotomy was performed, and the uterine stump appeared grossly cystic and thickened. Histopathological evaluation of the removed uterine stump and ovarian pedicles revealed cystic endometrial hyperplasia and no ovarian tissue. Fifteen days after surgery, the patient presented again with a sanguineous vulvar discharge. Vaginal cytology revealed predominantly …


Editor's Talk, Najwa Yanya Santiworakun Sep 2022

Editor's Talk, Najwa Yanya Santiworakun

Halal Insight

No abstract provided.


Sugar Causes Health Problems By Destroying Bacterial Mechanisms In Colon, Winai Dahlan Sep 2022

Sugar Causes Health Problems By Destroying Bacterial Mechanisms In Colon, Winai Dahlan

Halal Insight

No abstract provided.


“Doo Pla Cafe” “Doo Pla Café” – New Destination!! For Fish Lovers, Animal Lovers, And Nature Lovers. Delicious Food. Great Atmosphere. Located In Khlong 16 With The Space Over 42 Rai, Staff - Sep 2022

“Doo Pla Cafe” “Doo Pla Café” – New Destination!! For Fish Lovers, Animal Lovers, And Nature Lovers. Delicious Food. Great Atmosphere. Located In Khlong 16 With The Space Over 42 Rai, Staff -

Halal Insight

No abstract provided.


Technology And The Revolution Of Dairy Industry, Pornpimol Mahamad Sep 2022

Technology And The Revolution Of Dairy Industry, Pornpimol Mahamad

Halal Insight

No abstract provided.


Phytochemicals…Chemicals From Plants That You Need To Know, Kasinee Katelakha Sep 2022

Phytochemicals…Chemicals From Plants That You Need To Know, Kasinee Katelakha

Halal Insight

No abstract provided.


Gene Expression Signatures Identify Biologically And Clinically Distinct Tuberculosis Endotypes, Andrew R Dinardo, Tanmay Gandhi, Jan Heyckendorf, Sandra L Grimm, Kimal Rajapakshe, Tomoki Nishiguchi, Maja Reimann, H Lester Kirchner, Jaqueline Kahari, Qiniso Dlamini, Christoph Lange, Torsten Goldmann, Sebastian Marwitz, Dzif-Tb Cohort Study Group, Abhimanyu, Jeffrey D Cirillo, Stefan H E Kaufmann, Mihai G Netea, Reinout Van Crevel, Anna M Mandalakas, Cristian Coarfa Sep 2022

Gene Expression Signatures Identify Biologically And Clinically Distinct Tuberculosis Endotypes, Andrew R Dinardo, Tanmay Gandhi, Jan Heyckendorf, Sandra L Grimm, Kimal Rajapakshe, Tomoki Nishiguchi, Maja Reimann, H Lester Kirchner, Jaqueline Kahari, Qiniso Dlamini, Christoph Lange, Torsten Goldmann, Sebastian Marwitz, Dzif-Tb Cohort Study Group, Abhimanyu, Jeffrey D Cirillo, Stefan H E Kaufmann, Mihai G Netea, Reinout Van Crevel, Anna M Mandalakas, Cristian Coarfa

Faculty, Staff and Students Publications

BACKGROUND:In vitro, animal model and clinical evidence suggests that tuberculosis is not a monomorphic disease, and that host response to tuberculosis is protean with multiple distinct molecular pathways and pathologies (endotypes). We applied unbiased clustering to identify separate tuberculosis endotypes with classifiable gene expression patterns and clinical outcomes.

METHODS: A cohort comprised of microarray gene expression data from microbiologically confirmed tuberculosis patients was used to identify putative endotypes. One microarray cohort with longitudinal clinical outcomes was reserved for validation, as were two RNA-sequencing (seq) cohorts. Finally, a separate cohort of tuberculosis patients with functional immune responses was evaluated …


Associations Between Maternal Reports Of Periconceptional Fever From Miscellaneous Causes And Structural Birth Defects, Nithya Lakshmi Mohan Dass, Lorenzo D Botto, Sarah C Tinker, Mark A Canfield, Richard H Finnell, Michael Shayne Gallaway, Syed Shahrukh Hashmi, Adrienne T Hoyt, Wendy N Nembhard, Dorothy K Waller, National Birth Defects Prevention Study Sep 2022

Associations Between Maternal Reports Of Periconceptional Fever From Miscellaneous Causes And Structural Birth Defects, Nithya Lakshmi Mohan Dass, Lorenzo D Botto, Sarah C Tinker, Mark A Canfield, Richard H Finnell, Michael Shayne Gallaway, Syed Shahrukh Hashmi, Adrienne T Hoyt, Wendy N Nembhard, Dorothy K Waller, National Birth Defects Prevention Study

Faculty, Staff and Students Publications

BACKGROUND: Associations between birth defects and fevers attributed to colds, influenza, and urinary tract infections (UTIs) have been observed in previous studies. Our aim was to study associations between birth defects and fevers attributed to other causes.

METHODS: We analyzed data from 34,862 participants in the National Birth Defects Prevention Study, a multistate case-control study of major structural birth defects. Using multivariable logistic regression, we assessed the association between maternal report of fever during early pregnancy due to causes other than colds, influenza, or UTI and 36 categories of birth defects.

RESULTS: Maternal reports of fever due to other causes …


Mrnip Interacts With Sex Body Chromatin To Support Meiotic Progression, Spermatogenesis, And Male Fertility In Mice, Samina Kazi, Julio M Castañeda, Audrey Savolainen, Yiding Xu, Ning Liu, Huanyu Qiao, Ramiro Ramirez-Solis, Kaori Nozawa, Zhifeng Yu, Martin M Matzuk, Renata Prunskaite-Hyyryläinen Sep 2022

Mrnip Interacts With Sex Body Chromatin To Support Meiotic Progression, Spermatogenesis, And Male Fertility In Mice, Samina Kazi, Julio M Castañeda, Audrey Savolainen, Yiding Xu, Ning Liu, Huanyu Qiao, Ramiro Ramirez-Solis, Kaori Nozawa, Zhifeng Yu, Martin M Matzuk, Renata Prunskaite-Hyyryläinen

Faculty, Staff and Students Publications

Meiosis has a principal role in sexual reproduction to generate haploid gametes in both sexes. During meiosis, the cell nucleus hosts a dynamic environment where some genes are transcriptionally activated, and some are inactivated at the same time. This becomes possible through subnuclear compartmentalization. The sex body, sequestering X and Y chromosomes during male meiosis and creating an environment for the meiotic sex chromosome inactivation (MSCI) is one of the best known and studied subnuclear compartments. Herein, we show that MRNIP forms droplet‐like accumulations that fuse together to create a distinct subnuclear compartment that partially overlaps with the sex body …