Digital Commons Network^™

The Molecular Basis Of Diabetic Cardiomyopath, Ahmed Salaheldin Mustafa Ali Sultan

Dissertations

Diabetes mellitus (DM) is a major and worsening global health problem. Type 2 diabetes mellitus (T2DM) accounts for more than 90% of DM and the global epidemic of obesity largely explains the dramatic increase in the incidence and prevalence of T2DM over the past 20 years. Cardiovascular complications are the major cause of morbidity and mortality in diabetic patients. The electrocardiogram (ECG) of diabetic and obese patients is frequently disturbed. The aim of this project was to characterize and clarify the molecular basis of electro-mechanical dysfunction in the hearts of type 2 diabetic and type 2 diabetic/obese rats. Experiments were …

Characterization Of The Long Non-Coding Rna Proins In Human Pancreatic Β-Cell, Shareena Saeed Lootah

Dissertations

It is well established that the genome is pervasively transcribed. Only 2% of those transcripts are translated into proteins, and the remaining 98% are non-translated, generating the non-coding RNAs (ncRNAs) species. A close observation of these transcripts directed the scientific community to their increasing potential functional roles in the cells. Indeed, the literature exponentially unveils this notion, with many ncRNAs showing substantial and variable biological functions. The field is in its infancy; however, efforts are accelerating to discover and define this ocean of new species.

Long non-coding RNAs (lncRNAs) are sub-species of ncRNAs with an arbitrary size of more than …

Facing The Fringe, Laura Gradowski

Dissertations, Theses, and Capstone Projects

Fringe theories are a broad set of alternative views that mainstream scientists deny. Case studies from the past two centuries demonstrate that fringe theorists have sometimes been marginalized to the detriment of scientific advancements. While it is accepted that once in a blue moon comes a diamond in the rough, there are far more cases of fringe theories becoming mainstream than has been traditionally acknowledged. Indeed, fringe theories become mainstream with such regularity that our epistemic intolerance towards them is in need of urgent reexamination. With the recognition that tolerance is an epistemic virtue, we can view debates about theory …

Trauma And Effects Of Being Raised By A Parent With Bipolar I Disorder: A Theoretical Approach Utilizing Internal Family Systems, Daniella Vasquez

Dissertations

Bipolar I disorder (BD) is a somewhat rare mental health disorder that impacts not only the person diagnosed but also their family (Chang et al., 2001; Cook et al., 2005; Wearden et al., 2008). Children of parents with BD may experience complex trauma as inconsistencies in parenting, conflict within the household, and possible neglect or abuse may be present (Chang et al., 2001; Rusner et al., 2009; Wearden et al., 2008). Multiple developmental areas can be impacted for individuals who have endured complex trauma to include attachment, somatic distress, affect regulation, biology, behaviors, cognition, and identity (Cook et al., 2005; …

Subscription And Organization Information

Nebraska Bird Review

logists’ Union, Inc., as its official journal, and is sent to members not in arrears of dues. Annual subscription rates (on a calendar-year basis only): $25 in the United States and $35 in all other countries, payable in advance. Single copies are $7 each, postpaid, in the United States and $9 elsewhere. Send orders for back issues to Anita Breckbill, NOU Librarian, c/o Music Library, WMB 30, University of Nebraska, Lincoln, NE 68588-0101 (or at the email address listed below). Memberships in the NOU (on a calendar-year basis only): Active Household (one or more people) $25; Sustaining Household (one or …

Oxidative Stress Is A Potential Cost Of Synchronous Nesting In Olive Ridley Sea Turtles, B. Gabriela Arango, David C. Ensminger, Diana Daniela Moreno-Santillán, Martha Harfush-Meléndez, Elpidio Marcelino López-Reyes, José Alejandro Marmolejo-Valencia, Horacio Merchant-Larios, Daniel E. Crocker, José Pablo Vázquez-Medina

Faculty Research, Scholarly, and Creative Activity

Olive ridley sea turtles, Lepidochelys olivacea, exhibit a polymorphic reproductive behavior, nesting solitarily or in mass aggregations termed “arribadas”, where thousands of individuals nest synchronously. Arribada nesting provides fitness benefits including mate finding during nearshore aggregations and predator satiation at the time of hatching, but it is unknown if such benefits come with a physiological cost. We used plasma metabolite profiling, stable isotope analysis, biochemical and endocrine assays to test whether metabolic parameters differ between nesting modes, and if arribada nesting is associated with increased levels of oxidative damage compared to solitary nesting. Arribada nesters were bigger and had higher …

Menstrual Irregularities Following Covid-19 Vaccination: A Global Cross-Sectional Survey, Azza Sarfraz, Zouina Sarfraz, Muzna Sarfraz, Zainab Nadeem, Miguel Felix, Ivan Cherrez-Ojeda

Department of Paediatrics and Child Health

Introduction: The coronavirus disease 2019 (COVID-19) vaccination generates protective immunity against SARS-CoV-2 infection. There is no clear evidence of COVID-19 vaccine-induced menstrual irregularities.
Objective: To identify potential menstrual irregularities following COVID-19 vaccine among females.
Methods: A worldwide cross-sectional survey study was conducted from June 10, 2021, to July 10, 2021 using online mediums. The survey consisted of 15 questions divided into baseline characteristics, vaccination status and dosage, menstruation and relate factors, and thoughts and knowledge about menstrual irregularities. Non-probability convenience sampling method was used including 510 responses. The results were tabulated, with bivariate analysis and chi-square test results. The sensitivity …

Against Progress: Intellectual Property And Fundamental Values In The Internet Age, Or Cohen Sasson

Articles

No abstract provided.

Low Soil Nitrogen And Moisture Limit The Expansion Of The Invasive Grass, Megathyrsus Maximus (Guinea Grass) In Semi-Arid Soils, E. Penelope Holland, Vanessa Thomas, Pushpa G. Soti

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

The goal of this study was to predict the range expansion potential of an invasive forage grass, Guinea grass (Megathyrsus maximus). We collected rhizosphere soil samples of M. maximus and coexisting species from 150 different locations and analysed them for soil properties. We estimated the probability of M. maximus presence as a function of soil moisture, organic matter, pH, salinity, total N, and CN ratio using logistic regression. Presence of M. maximus was associated with higher soil moisture, higher organic matter, pH, and nitrogen, but lower salinity and CN ratio. Soil nitrogen and moisture …

Monkeypox: Experts Give Virus Variants New Names

Saudi Medical Journal

No abstract provided.

Polyphenols And Small Phenolic Acids As Cellular Metabolic Regulators, Mark Obrenovich, Yi Li, Moncef Tayahi, V. Prakash Reddy

Chemistry Faculty Research & Creative Works

Polyphenols and representative small phenolic acids and molecules derived from larger constituents are dietary antioxidants from fruits, vegetables and largely other plant-based sources that have ability to scavenge free radicals. What is often neglected in polyphenol metabolism is bioavailability and the role of the gut microbiota (GMB), which has an essential role in health and disease and participates in co-metabolism with the host. The composition of the gut microbiota is in constant flux and is modified by multiple intrinsic and extrinsic factors, including antibiotics. Dietary or other factors are key modulators of the host gut milieu. In this review, we …

Risk Of Type 2 Diabetes Among Individuals With Excess Weight: Weight Trajectory Effects, Arthur H Owora, David B Allison, Xuan Zhang, Nana Gletsu-Miller, Kishore M Gadde

Children’s Nutrition Research Center Staff Publications

PURPOSE OF REVIEW: Increased risk of type 2 diabetes mellitus (T2D) among individuals with overweight or obesity is well-established; however, questions remain about the temporal dynamics of weight change (gain or loss) on the natural course of T2D in this at-risk population. Existing epidemiologic evidence is limited to studies that discretely sample and assess excess weight and T2D risk at different ages with limited follow-up, yet changes in weight may have time-varying and possibly non-linear effects on T2D risk. Predicting the impact of weight change on the risk of T2D is key to informing primary prevention. We critically review the …

The Youngest Boy (Book Review), James C. Schaap

Pro Rege

Reviewed Title: The Youngest Boy by Jim Heynen. Duluth, MN: Holy Cow! Press, 2021. 127 pp. ISBN: 9781513645599.

Wonderfully Made: A Protestant Theology Of The Body (Book Review), Alida Sewell

Pro Rege

Reviewed Title: Wonderfully Made: A Protestant Theology of the Body by John W. Kleinig. Bellingham, WA: Lexham Press, 2021. 235 pp. ISBN: 9781683594680.

Moonshine Promises (Book Review), Shaun Stiemsma

Pro Rege

Reviewed Title: Moonshine Promises by John Van Rys. Eugene, Oregon: Resource Publications, An Imprint of Wipf and Stock Publishers, 2021. 228 pp. Hardcover ISBN: 97816667112629.

Role Of The G Protein Beta Gamma Subunits In Serotonin Transporter Dynamics, Nora Awadallah

Dissertations, Theses, and Capstone Projects

Serotonin is a vital neurotransmitter and hormone with significant roles in almost every organ system. In the central nervous system, serotonin mediates physiological functions that in turn guide behavior and mood. Here, serotonin is released from serotonergic neurons and exerts its effects through serotonin receptors. Regulation of serotonin neurotransmission is important for the maintenance of its physiological functions; thus, extracellular serotonin must be sequestered to limit the intensity and duration of serotonin transmission. Disproportionate transmission is strongly linked with neurological and psychiatric ailments.

Extracellular serotonin levels are primarily mediated by the serotonin transporter (SERT), a critically important plasma membrane protein …

Teaching Revolution: Women Primary School Teachers, Race, And Social Reproduction In Cuba, Angela M. Crumdy

Dissertations, Theses, and Capstone Projects

In November of 2018, Dr. Miriam Nicado García was appointed Rector of the University of Havana, making her the first woman of color to hold the position in the institution’s 209-year existence. This is undoubtedly a historic event that serves as a starting point to consider the intersections of formal education and social difference on the island from the perspective of education workers. Despite claims that Cuba is a racial democracy in which all citizens are unified by a shared national identity, an assessment of the education system through the experiences of women educators can be used as a diagnostic …

Primitivism, Performance Studies, And Modernist Time: Tracing An Alternative Genealogy Of Performance Studies Through Case Studies In Modernist Cultural Appropriation, Stephanie Vella

Dissertations, Theses, and Capstone Projects

This dissertation traces a genealogy of research methodologies for documenting, transmitting, and analyzing embodied, non-textual performance practices from the late-nineteenth through early-twentieth centuries. I uncover intersections between these methods and the conflations of race and temporality that are ubiquitously threaded through modernist cultural practices during this time in the form of primitivism. The researchers whose work I analyze all saw European modernity as fundamentally detached from physical culture, while viewing other cultures—especially those of the people most directly threatened by colonial and capitalist expansion during this time—as having access to a “lost” corporeal knowledge. I argue that primitivism is not …

Role Of Nuclear Lamins In Oligodendrocyte Lineage Cells, Camila Yattah

Dissertations, Theses, and Capstone Projects

Differentiation of oligodendrocytes from progenitor cells is a highly regulated process characterized by a series of molecular changes, resulting in nuclear and morphological features unique to the mature oligodendrocyte state. Heterochromatin formation starting at the nuclear periphery, as well as increased nuclear rigidity are characteristically observed. The nuclear periphery is characterized by the presence of the nuclear lamina and it has been implicated in higher-order genome organization in cells. Lamins are the protein components of the nuclear lamina, and their expression is dependent upon the cell differentiation stage of the cells. While Lamin B1 (LMNB1) expression is high in progenitors …

Predicting Stress In Russian Using Modern Machine-Learning Tools, John Schriner

Dissertations, Theses, and Capstone Projects

In the Russian language, stress on a word is determined via often complex patterns and rules. In this paper, after examining nearly a century of research in stress rules and methods in Russian, we turn to see if modern machine learning tools can aid in predicting stress. Using A.A. Zaliznyak’s dictionary grammar and over 300,000 word forms, we derived stress codes to aid in predicting which syllable primary stress falls on. We trained an LSTM neural network on the data and conducted eight experiments with added features such as lemma, part of speech, and morphology. While the model performed better …

Ssri-Induced Emotional Blunting: A Study Of Cognitive Changes In Pharmaceutically Treated Depression, Carly Tocco

Dissertations, Theses, and Capstone Projects

Objective: In recent years, approximately 12.7% of the American population are on a prescribed antidepressant medication. Selective Serotonin Reuptake Inhibitors (SSRIs) are a widely used pharmacological treatment for depressive and anxiety disorders, primarily due to their tolerance levels, mild side effects in comparison to other antidepressants, and broad range of clinical indications. However, there are still numerous concerns about SSRIs’ ability to improve depressive symptoms without adding side effects such as sexual dysfunction, gastrointestinal upset, and a restricted range of emotions. Although patients typically claim that they have less emotional pain while on SSRIs than they do during a depressive …

The Impact Of Cannabis Use On Neuropsychological And Neural Biomarkers Of Treatment Response In Schizophrenia Spectrum Disorders, Melanie B. Thies

Dissertations, Theses, and Capstone Projects

Cannabis use among patients with schizophrenia-spectrum disorders (SSD) is at significantly greater levels than in healthy populations but the impact of cannabis on neural mechanisms of clinical improvement is poorly understood. Cognitive functioning and neural connectivity are disrupted as a result of both SSD and cannabis use, and research indicates that neuropsychological capacity and connectivity of the striatum, a region involved in salience and reward processing, may be integral to effective antipsychotic drug (AP) treatment response. Despite this overlap, no previous research has investigated the effect of cannabis on the brain functions implicated in AP treatment response. The present study …

Globalism And Identity In Taiwanese Contemporary Art, 1978–2009, Chu-Chiun Wei

Dissertations, Theses, and Capstone Projects

Taiwanese contemporary art emerged in the 1980s and rapidly flourished in the 1990s, nourished by the process of democratization and the construction of Taiwanese consciousness prompted by the lifting of martial law in 1987. This dissertation makes two claims. Firstly, that Taiwanese contemporary art after 2000 can be understood as “post-national,” due to the country’s marginal position in the world and contentious status as a nation-state. Secondly, that Taiwanese post-national art differentiates itself from postcolonial/post-martial law art of the late 1980s and 1990s on the basis of its globalism. The three artists surveyed by the dissertation each exemplify different …

A Labor Of Livingness: Oral Histories Of Formerly Incarcerated Black Women, Robin Mcginty

Dissertations, Theses, and Capstone Projects

Anchored in the political subjectivity of formerly incarcerated Black women, “A Labor of Livingness: Oral Histories of Formerly Incarcerated Black Women” is a project situated at the intersections of Black geographies and Black Feminist thought that considers a re/imagination of the ‘living prison’ experiences of formerly incarcerated Black women. I offer the term “a labor of livingness” as the liberatory articulation and everyday practices of resistance to the prison as a site of ‘living death’ that is reflective of the carceral experiences of currently and formerly incarcerated Black women. Attentive to the prison as a repository of epistemological knowledge production, …

Eating People Is Might: Power And The Representation Of Anthropophagy In Antiquity, Christopher Weimer

Dissertations, Theses, and Capstone Projects

For several decades, scholars have read cannibalism in ancient texts as an ethnographic and rhetorical strategy to marginalize, minimize, demonize, or otherwise denigrate ‘the Other.’ It is seen as a characteristic of the wild, the savage, the uncivilized, and the bestial, something one attributes only to other people. This project challenges that assertion. In situating the many varied references to eating people in ancient Greek, Near Eastern, and Roman literature within their historical and generic contexts, I provide an alternative reading of the purpose of these accusations and stories. I argue that consumption of another is a statement of power, …

The Value Of Nfts, Angelina Tham

Dissertations, Theses, and Capstone Projects

Non-fungible token stories have flooded the media since the beginning of the COVID-19 pandemic. NFTs have changed the public’s views on art, finances, and the self. The emergence of Web 3 redefined ways of self expression with the help of NFTs. What are NFTs, how are they valuable, and how will they shape the future of digital art? The data visualization for this project indicates that the most popular type of crypto art is in the style of a profile picture. The discussion suggests that NFTs are in their infancy and there will be more to come from digital art, …

Terror En El Orinoco: Formas Del Espanto Animal Y Vegetal En La Historia Natural De José Gumilla, Roberto E. Martinez Bachrich

Dissertations, Theses, and Capstone Projects

“Terror in the Orinoco: Forms of Animal and Plant Horror in the Natural History of José Gumilla”, analyzes the repertoire of terrifying plants and animals that the Spanish Jesuit missionary José Gumilla described in his 1745 compendium El Orinoco Ilustrado y Defendido —a work that, surprisingly, has not been read from the perspective of animal and plant studies. Based on Spanish old models of the natural history of the Indies (Fernández de Oviedo, Acosta), Gumilla reconstructs an archive of monstrous beings (alligators, piranhas, snakes, poisonous plants) that challenges old medieval religious discourses when confronted with the nascent illustrated discourses. My …

Dietary Regulation Of Silent Synapses In The Dorsolateral Striatum, Allison M. Meyers

Dissertations, Theses, and Capstone Projects

Obesity and drugs of abuse share overlapping neural circuits and behaviors. Cravings for drugs of abuse increase during abstinence, a phenomenon known as incubation. In obesity, increased craving is observed in individuals during dieting. Diets often fail, with return to- or increase above- original weight. The extent to which this reflects an incubation phenomenon has not been carefully examined. One mechanism underlying incubation is the reemergence of a developmental mechanism called silent synapses. Silent synapses are 'temporary' synapses that are important for remodeling brain circuits. They are prevalent during early development but largely disappear by adulthood. Drugs of abuse increase …

Destination Icaic: Cosmopolitan Intellectuals, Documentary Film And The Image Of The Cuban 1960s, Gabriel Arce-Riocabo Rollins

Dissertations, Theses, and Capstone Projects

This study analyzes the interaction between foreign intellectuals and ICAIC (Instituto cubano de artes e industrias cinematográficas) in shaping the image of Cuba in the 1960s. I make the case that the idea of Revolution was a product of cosmopolitan intellectual engagement and that in this process documentary film was a privileged medium. By tracing the development of normative stories of commitment, cosmopolitanism, and aesthetic experimentation embodied both in written texts and travel essay films, I argue that such circulation destabilizes fixed ideas of Cuban, Revolutionary or Intellectual. The archive of Danish filmmaker and ICAIC collaborator Theodor Christensen as well …

Transcriptional Mechanisms Of Neuroprotection In Excitotoxicity Driven Neurodegeneration In C. Elegans, Zelda Z. Mendelowitz

Dissertations, Theses, and Capstone Projects

Excitotoxicity is notorious for triggering neuronal cell death in both developmental and adult-onset neurodegenerative diseases. In excitotoxicity, excessive concentrations of Glutamate in the synapse overstimulate Glutamate Receptors (GluRs) on postsynaptic neurons. While GluR mediated degenerative mechanisms remain obscure, GluR activation was surprisingly found to also have a neuroprotective effect through activation of specific transcriptional programs. To identify evolutionarily conserved transcriptional programs in neuroprotection we use a C. elegans model of excitotoxic necrosis (glt-3;nuIs5). We have identified that non-canonical activation of the transcription factor CRH-1/CREB mediates neuroprotection in our excitotoxicity model. We found the Histone Acetyl Transferase, MYS-1/KAT6, and the neuronal …