Digital Commons Network^™

Katharine Bement Davis: Defying Expectations As A Woman And In The Study Of Women, Ella Hester

Dissertations, Theses, and Capstone Projects

Katharine Bement Davis’ (1860-1935) life and career as a highly educated scientist and Progressive activist placed her at the forefront of various moral panic debates at the turn of the twentieth century. Davis was born into a staunch abolitionist and suffragist family in upstate New York in 1860. Her family’s politics were grounded in progressive Protestant principles which allowed her to gain access to higher education as a white woman from a middle-class family. Her education left her poised to use the latest scientific research to shape Progressive dogma in the 1910s and 1920s. Davis’ education and the groundbreaking research …

The Rise Of A New Machine: Dominican Political Mobilization And Incorporation In New York City From 1991 To The Present, Fernando Aquino

Dissertations, Theses, and Capstone Projects

This research project analyzes the factors that influenced the pace of political progress and incorporation of Dominican ancestry candidates in New York City from 1991 to the present. Despite this immigrant group’s relatively recent arrival, as of August 2022, thirteen Dominican-American New York City residents currently hold seats in the city council, state legislature, and the U.S. Congress.

This achievement is remarkable in comparison to the much slower historical political progress for Puerto Ricans and other Latino/a communities in New York City. This dissertation uses the variation in the composition, relative position, and political contexts facing Dominican communities across four …

Gospels Of (Anti)Inequality: The Politics Of Biblical Interpretation In The New Poor People’S Campaign And Capitol Ministries, Jonathan Peter Tschudy

Dissertations, Theses, and Capstone Projects

This dissertation explores the role of biblical interpretation in the politics of inequality in the United States. Building on scholarship in American Political Development that identifies ideas as integral to institution building, I analyze the interplay between biblical interpretations, organizational structures, and political strategies within two contemporary religio-political groups: the New Poor People’s Campaign (NPPC) and Capitol Ministries (CM). Methodologically, I combine in-depth, interpretative readings of primary source documents with an historical institutional analysis of the secondary literature on the role of religion in American politics. I argue that the two organizations’ elite leaders – Reverends William Barber II and …

The Cultural Battle Against The Dollar: Struggles Over Hoarding And Democracy In The Twilight Of Argentina's Soy Boom, Charles Dolph

Dissertations, Theses, and Capstone Projects

Argentina’s economy has undergone a profound transformation over recent decades from beef and wheat to soybeans and derivative products as the country’s main export commodity and source of foreign exchange. The dissertation traces this shift against the historical backdrop of the country’s peculiar class, territorial, and state formations as the only Latin American nation where agrarian reform has been altogether absent. This perspective on Argentina’s experience with the so-called Green Revolution in agriculture reveals it as an expansive project in which the U.S. dollar figures as an instrument of pacification and acquiescence to agribusiness hegemony. Amid an early twenty-first century …

Historical Ecology Of Norse Greenland: Zooarchaeology And Climate Change Responses, Konrad Smiarowski

Dissertations, Theses, and Capstone Projects

This thesis invokes Historical Ecology approach to better understand human impacts on marine and terrestrial ecosystems, and the creation of cultural landscapes and seascapes in Norse Greenland. It also investigates climate impacts on human economic strategies, as they vary substantially by island and region in the North Atlantic but were especially important in arctic Greenland.

The analysis centers on the animal bone data and uses both existing and newly generated zooarchaeological collections to contribute to the study of Norse Greenland and its place in human ecodynamics research. The newly analyzed archaeofauna shows that the culturally Nordic European settlers used to …

“The Theory Is Not Yet Music”: An Analysis Of Pierre Schaeffer’S Etude Aux Allures, Jacob Sachs-Mishalanie

Dissertations, Theses, and Capstone Projects

Throughout his career, Pierre Schaeffer composed several sound works to test and inspire his evolving musical theories. By composing with edited sound recordings, rather than traditional musical instruments, he hoped to discover new ways of creating musical structures based on sound parameters other than pitch. This study is an analysis of Schaeffer’s sound work Etude aux allures. This Etude examines the musical potential of the sound parameter allure, which is Schaeffer’s term for the pulsed modulation of pitch, volume, or other sound parameters. Without the existence of a standardized analytical methodology, the Etude is viewed from several perspectives. First, a …

Novel Therapeutic Strategies For Alzheimer’S Disease: Targeting Toll-Like Receptor Signaling And A Multi-Target Approach, Giovanni Oliveros

Dissertations, Theses, and Capstone Projects

Alzheimer’s disease (AD) is multifactorial, and its hallmarks include the formation of amyloid-beta (Ab) plaques and neurofibrillary tau tangles, accompanied by an increase in glial cell activation, culminating in neurodegeneration, chronic neuroinflammation, and cognitive decline in human patients. AD will cost the United States over $300 million this year alone and is projected to cost over $1 trillion by 2050, AD is a serious concern for the aging population, and efforts need to be redirected towards more effective therapeutic intervention strategies. Drugs aimed at halting AD progression have so far proven unsuccessful due to the development of pharmaceuticals that target …

The Behavioral And Gene Expression Effects Of Loss Or Exhaustion Of Sonic Hedgehog From Dopamine Neurons, Dustin R. Zuelke

Dissertations, Theses, and Capstone Projects

Mesencephalic dopamine neurons (DAN) signal motivation and reward prediction errors. Their collective functions are considered critical for the translation of thought into context appropriate actions. Dopaminergic dysfunction has severe consequences: (1) DAN degeneration is a major determinate of Parkinson’s Disease (PD), (2) disturbed dopaminergic signaling in schizophrenia leads to unorganized learning, and (3) chemically induced dopaminergic signaling results in impulse control disorders (ICDs) and life-threatening addictions. The use of the dopamine (DA) precursor L-Dopa for DA replacement therapy in PD patients produces motor and behavioral side-effects such as L-Dopa induced dyskinesias (LID), ICDs, and a propensity for opioid addiction. Despite …

The Differential Effects Of Acoustic Discriminations On Operant Learning Performance And Neurogenesis In Male And Female Zebra Finches, Kristena L. Newman

Dissertations, Theses, and Capstone Projects

Adult neurogenesis, the creation of new neurons, occurs throughout the lifespan in most organisms. However, though neuronal proliferation occurs daily, most of these neurons do not survive to become incorporated into preexisting neural circuitry and become fully functioning neurons. In the mammalian brain, adult neurogenesis occurs within the hippocampus, a brain region known to be important in learning and memory. In rats, successful acquisition of certain learning tasks increased new neuron numbers when the learning was sufficiently challenging (Curlik and Shors, 2011). It has also been demonstrated that a spatial discrimination task requires new neurons when the discrimination is more …

Purity, Exclusion, And Political Order In Colombia, Osha Smith-Gittelman

Dissertations, Theses, and Capstone Projects

This dissertation examines the relationship between purity and order, and the ways this relationship informs and reproduces exclusionary forms of governance. The starting point for this analysis is the puzzling use of the language of limpieza social [social cleansing] as a justification for violence in Latin America. Such language is publicly disseminated by vigilantes, criminal organizations, paramilitaries, and other extralegal armed actors as a frame for violence against those presumed to be criminals, drug users, sex workers, unhoused, LGBTQ, or mentally ill. Much has been written on criminal and political violence in the region, but there has been less emphasis …

Graphic Novels In The Foreign Language Classroom: Teaching Central American History In The Target Language, Vanessa Elizabeth Guzmán

Dissertations, Theses, and Capstone Projects

Graphic novels are becoming increasingly helpful in the foreign language classroom. As a Spanish teacher in the Bronx, I have introduced numerous graphic novels into my lessons. Some graphic novels include familiar characters and are presented in a translated work, while others are graphic novels that were originally printed in Spanish. I have witnessed the advantages of using graphic novels in my classroom as the illustrations provide my readers with context clues to better understand the reading. I have also found some graphic novels that focus on historical events in Latin America but these works were either written entirely in …

Assembling The African City: Music Streets And Associational Life In Dakar's Médina, Brendan Kibbee

Dissertations, Theses, and Capstone Projects

What can you understand about a city through its music? Most days and nights in Dakar’s Médina­­––a crowded quartier populaire adjacent to the city’s central administrative zone–– streetscapes are transformed by musical assemblies, including life cycle ceremonies and events produced by the neighborhood’s robust array of civic and religious associations. This dissertation examines how the confluence of music, public spaces (streets), and associational life shapes the possibilities of urban living in the contemporary African city. The musical assemblies that fill the neighborhood, I argue, spatialize social life in the city, organizing people’s movements, exposing them to a common sense-world, and …

Mechanism Of Tau Propagation: Putative Therapeutic Approaches, Viktoriya Morozova

Dissertations, Theses, and Capstone Projects

One of the characteristics of Alzheimer’s disease and associated tauopathies is the accumulation and aggregation of hyperphosphorylated tau protein. The biological activity of tau is to bind to tubulin and promote its assembly into microtubules with subsequent stabilization of the latter. When tau gets hyperphosphorylated it cannot bind to tubulin and carry on its function, instead, it binds to normal tau and sequesters it from microtubules leading to disruption of microtubular assembly and ultimately to the death of neurons. Our lab had previously shown that tau phosphorylation sites 199, 212, 231, and 262, combined with the FTDP-17 mutation R406W (Pathological …

A Polypharmacological Approach To Relapse Prevention In An Animal Model Of Heroin Addiction, Scott T. Ewing

Dissertations, Theses, and Capstone Projects

Chemical compounds that target dopamine (DA) D1 or D3 receptors have shown promise as potential interventions in animal models of cue-induced relapse. However, undesirable side effects or pharmacodynamic profiles have limited the advancement of new compounds in preclinical studies when administered as independent treatments. In this series of experiments, we explored the effects of co-administration of a D1-recepter partial agonist (SKF 77434) and a D3-receptor antagonist (NGB 2904) in heroin-seeking rats within a ‘conflict’ model of abstinence and cue-induced relapse. Rats were first trained to press a lever to self-administer heroin and drug delivery was paired contingently with cues (e.g., …

Effects Of Redundancy Of Multimedia Instruction On Spanish Reading And Listening Skills, Charles Raffaele

Dissertations, Theses, and Capstone Projects

The redundancy principle of multimedia learning indicates that people learn better from graphics and narration simultaneously than from graphics, narration, and printed text simultaneously. The current study investigated whether the redundancy principle may apply to multimedia instruction of correspondences between a second language (L2) and a native language’s reading and listening content. 100 college students in New York City learned correspondences between Spanish and English words and phrases in a counterbalanced within-subjects design, from three trials of video instruction that was redundant (including text as captions) or non-redundant (including text as non-concurrent text slides). For each condition, participants completed tests …

Titan Success: Faculty Behind The Scenes, September, Thorpe Center

Publications from the Associate Deans

No abstract provided.

A Sentimental Education, Hannah Mcgregor

WLU Press Books

How do you tell the story of a feminist education, when the work of feminism can never be perfected or completed? In A Sentimental Education, Hannah McGregor, the podcaster behind Witch, Please and Secret Feminist Agenda, explores what podcasting has taught her about doing feminist scholarship not as a methodology but as a way of life.

Moving between memoir and theory, these essays consider the collective practices of feminist meaning-making in activities as varied as reading, critique, podcasting, and even mourning. In part this book is a memoir of one person’s education as a reader and a thinker, and …

Biology Through The Lens Of Trauma: An Empirical Review Of Trauma Treatments, Adela Gharabeki

Loma Linda University Electronic Theses, Dissertations & Projects

The present literature review aims at mending the research to practice gap for the treatment of Post-Traumatic Stress Disorder (PTSD). Biological mechanisms of the stress response system are explored as they pertain to trauma and its subsequent effects on the brain and body. In addition, American Psychological Association (APA) recommended evidence-based treatments for PTSD are reviewed as well as more recent emerging somatic therapies. There is a critical need for further development in the area of both topdown and bottom-up interventions. Biological working mechanisms remain unknown for a majority of treatments and physiological measures are scarcely used in treatment outcome …

Biosecurity Council Of Western Australia Annual Report 2021/2022, Biosecurity Council Of Western Australia

Biosecurity published reports

Understanding the needs and challenges of industry, community and government is key to providing relevant and constructive advice to government. During 2021/22, the Council continued to monitor biosecurity-related developments at national and State levels and proactively engaged with industry, community and government on biosecurity matters.

The key areas of advice that were progressed during the year were:

• The use of biological control agents to manage pests;
• Mechanisms for funding biosecurity and pest management; and
• Other matters as requested by the Minister.

Gender & Sexuality Services Newsletter, September 2022, University Of Northern Iowa. Gender & Sexuality Services.

Gender & Sexuality Services Newsletter

In This Issue:

--- We're Here for You
--- Diversity, Inclusion & Social Justice
--- Program Preview
--- Harvest Conference
--- Conference Opportunity
--- Safe Zone Ally training
--- Seeking Volunteers
--- Upcoming Events

Membrane-Anchored And Tumor-Targeted Il12 (Attil12)-Pbmc Therapy For Osteosarcoma, Qing Yang, Jiemiao Hu, Zhiliang Jia, Qi Wang, Jing Wang, Long Hoang Dao, Wendong Zhang, Sheng Zhang, Xueqing Xia, Richard Gorlick, Shulin Li

Faculty, Staff and Student Publications

Purpose: Chimeric antigen receptor (CAR) T-cell therapy has shown great promise for treating hematologic malignancies but requires a long duration of T-cell expansion, is associated with severe toxicity, and has limited efficacy for treating solid tumors. We designed experiments to address those challenges.

Experimental design: We generated a cell membrane-anchored and tumor-targeted IL12 (attIL12) to arm peripheral blood mononuclear cells (PBMC) instead of T cells to omit the expansion phase for required CAR T cells.

Results: This IL12-based attIL12-PBMC therapy showed significant antitumor efficacy in both heterogeneous osteosarcoma patient-derived xenograft tumors and metastatic osteosarcoma tumors with no observable toxic effects. …

Estrogen-Related Receptor Alpha Is An Ampk-Regulated Factor That Promotes Ischemic Muscle Revascularization And Recovery In Diet-Induced Obese Mice, Danesh H Sopariwala, Andrea S Rios, Mi Kyung Park, Min Sup Song, Ashok Kumar, Vihang A Narkar

Faculty, Staff and Student Publications

Obesity and type II diabetes are leading causes of peripheral arterial disease (PAD), which is characterized by vascular insufficiency and ischemic damage in the limb skeletal muscle. Glycemic control is not sufficient to prevent progression of PAD, and molecular targets that can promote muscle neo-angiogenesis in obesity and diabetes remain poorly defined. Here, we have investigated whether nuclear receptor estrogen-related receptor alpha (ERRα) can promote ischemic revascularization in the skeletal muscles of diet-induced obese (DIO) mice. Using muscle-specific ERRα transgenic mice, we found that ERRα overexpression promotes revascularization, marked by increased capillary staining and muscle perfusion in DIO mice after …

Problematic Social Media Use, Social Comparison, And Defeat: An Intensive Longitudinal Investigation, Natalia Macrynikola

Dissertations, Theses, and Capstone Projects

Self-injurious thoughts and behaviors (SITBs) have steadily risen over the past two decades. The simultaneous dramatic increase in social media use has fueled concerns that using social media may be contributing to suicide risk. Although an emerging body of evidence reveals associations between certain patterns of social media use and SITBs, most research studies have not been designed to assess the temporal order of these variables and have neglected to investigate mechanisms underlying such associations. As a result, whether and how social media use may be conferring suicide risk remains unclear. To address this gap, the present study examined a …

An Interdisciplinary Approach To The Epistemic Value Of Moral Ambiguity, Jordan Wylie

Dissertations, Theses, and Capstone Projects

Morality is a critical aspect of life––it influences how we think, design political and legal systems, who we connect with, our norms, and the types of stories we tell. Yet, even with the well documented influence of morality on many aspects of life, exactly what makes moral themes so fascinating remains elusive. This dissertation aims to introduce Moral Worldbuilding as a theory for understanding our epistemic drives toward morally ambiguous and morally bad content.

In Chapter I, we introduce the problem of moral badness, which is not well handled by extant moral literature. To combat this, we offer a new …

Natural Striatal Signaling Dynamics During Food Approach, Devry Mourra

Dissertations, Theses, and Capstone Projects

Reduced dopamine (DA) signaling has been hypothesized to induce compulsive overeating in obesity. However, DA signaling facilitates food pursuit by acting on direct and indirect pathways. This disparity between why individuals compulsively overeat despite decreased DA and satiety signals is unclear. Characterizing how DA and direct/indirect pathways respond to satiation may elucidate how satiety signals become overwritten in obesity. The food's palatability may underlie this, which is putatively thought to override the satiety hormones since it directly increases DA signaling, resulting in the increased appetitive drive. We determined the pattern of dopamine and pathway-specific medium spiny neuron (MSN) activity across …

Repurposing Epigenetic Inhibitors To Target The Clostridioides Difficile-Specific Dna Adenine Methyltransferase And Sporulation Regulator Cama, Jujun Zhou, John R Horton, Dan Yu, Ren Ren, Robert M Blumenthal, Xing Zhang, Xiaodong Cheng

Faculty, Staff and Student Publications

Epigenetically targeted therapeutic development, particularly for SAM-dependent methylations of DNA, mRNA and histones has been proceeding rapidly for cancer treatments over the past few years. However, this approach has barely begun to be exploited for developing new antibiotics, despite an overwhelming global need to counter antimicrobial resistance. Here, we explore whether SAM analogues, some of which are in (pre)clinical studies as inhibitors of human epigenetic enzymes, can also inhibit Clostridioides difficile-specific DNA adenine methyltransferase (CamA), a sporulation regulator present in all C. difficile genomes sequenced to date, but found in almost no other bacteria. We found that SGC0946 (an …

Cost-Benefit Analysis Of The Saudi Land Bridge Project, Faris J. Alotaibi

Theses and Dissertations

Projects are the backbone of economic thrive of nations, especially infrastructure projects. It’s counted as the base layer of allowing economic trade between beneficiaries. Railway projects have always been a huge element in increasing trade operations between Saudi Arabia and the rest of the world, by providing an efficient and environmentally friendly way that is capable of hauling large loads of exports all the way to the seaports and from there to the rest of the world. The Saudi land bridge project will cost about $11 billion and will provide a new link between the existent railway in the eastern …

Analytic Case Study Using Unsupervised Event Detection In Multivariate Time Series Data, Jeremy M. Wightman

Theses and Dissertations

Analysis of cyber-physical systems (CPS) has emerged as a critical domain for providing US Air Force and Space Force leadership decision advantage in air, space, and cyberspace. Legacy methods have been outpaced by evolving battlespaces and global peer-level challengers. Automation provides one way to decrease the time that analysis currently takes. This thesis presents an event detection automation system (EDAS) which utilizes deep learning models, distance metrics, and static thresholding to detect events. The EDAS automation is evaluated with case study of CPS domain experts in two parts. Part 1 uses the current methods for CPS analysis with a qualitative …

A Methodological Framework For Parametric Combat Analysis, Dustin L. Hayhurst Sr.

Theses and Dissertations

This work presents a taxonomic structure for understanding the tension between certain factors of stability for game-theoretic outcomes such as Nash optimality, Pareto optimality, and balance optimality and then applies such game-theoretic concepts to the advancement of strategic thought on spacepower. This work successfully adapts and applies combat modeling theory to the evaluation of cislunar space conflict. This work provides evidence that the reliability characteristics of small spacecraft share similarities to the reliability characteristics of large spacecraft. Using these novel foundational concepts, this dissertation develops and presents a parametric methodological framework capable of analyzing the efficacy of heterogeneous force compositions …

Factors Affecting Hospital Readmission Rates Following An Acute Coronary Syndrome: A Systematic Review, Amineh Rashidi, Lisa Whitehead, Courtney Glass

Research outputs 2014 to 2021

Aim

To synthesise quantitative evidence on factors that impact hospital readmission rates following ACS with comorbidities.

Design

Systematic review and narrative synthesis.

Data Sources

A search of eight electronic databases, including Embase, Medline, PsycINFO, Web of Science, CINAHL, Cochrane Library, Scopus and the Joanna Briggs Institute (JBI).

Review Methods

The search strategy included keywords and MeSH terms to identify English language studies published between 2001 and 2020. The quality of included studies was assessed by two independent reviewers, using Joanna Briggs Institute (JBI) critical appraisal tools.

Results

Twenty-four articles were included in the review. All cause 30-day readmission rate was …