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Inhibition Of Tumor Microenvironment Cytokine Signaling Sensitizes Ovarian Cancer Cells To Antiestrogen Therapy, Lijun Tan, Katelyn Tondo-Steele, Caroline Foster, Carrie Mcilwain, Danielle E. Bolland, Howard C. Crawford, Andrew Sciallis, Karen Mclean

Hematology/Oncology Articles

Antiestrogen therapy (AET) is an alternative to cytotoxic chemotherapy for recurrent ovarian cancer, yet the often short duration of response suggests mechanisms of resistance. We previously demonstrated that tumor microenvironment interleukin-6/leukemia inhibitory factor (IL6/LIF) cytokines induce tumor cell JAK-STAT signaling to promote cancer growth. Crosstalk between estrogen signaling and cytokine signaling has been reported. Therefore, we sought to characterize the impact of IL6/LIF signaling on estrogen signaling in epithelial ovarian cancer and investigate the efficacy of combination therapy. We first assessed patient tumors for cytokine expression and compared it with response to AET to determine clinical relevance. In vitro, we …

Capsaicin Inhibits Multiple Voltage-Gated Ion Channels In Rabbit Ventricular Cardiomyocytes In Trpv1-Independent Manner, Dmytro Isaev, Keun-Hang Susan Yang, Waheed Shabbir, Frank Christopher Howarth, Murat Oz

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Capsaicin is a naturally occurring alkaloid derived from chili pepper which is responsible for its hot, pungent taste. It exerts multiple pharmacological actions, including pain-relieving, anti-cancer, anti-inflammatory, anti-obesity, and antioxidant effects. Previous studies have shown that capsaicin significantly affects the contractility and automaticity of the heart and alters cardiovascular functions. In this study, the effects of capsaicin were investigated on voltage-gated ion currents in rabbit ventricular myocytes. Capsaicin inhibited rapidly activated (I_Kr) and slowly activated (I_Ks) K⁺ currents and transient outward (I_to) K⁺ current with IC₅₀ values of 3.4 µM,14.7 µM, …

September 26, 2022

The Gavel Gazette

No abstract provided.

Editorial: C. Elegans Hostmicrobiome Interactions: From Medical To Ecological And Evolutionary Model, Michael A. Herman, Javier E. Irazoqui, Buck S. Samuel, Nic Vega

School of Biological Sciences: Faculty Publications

No abstract provided.

Editorial: C. Elegans Host-Microbiome Interactions: From Medical To Ecological And Evolutionary Model, Michael A. Herman, Javier E. Irazoqui, Buck S. Samuel, Nic Vega

School of Biological Sciences: Faculty Publications

Microbiomes often form specific functional associations with their hosts. Correlations between microbiome membership and states of host health and disease abound in many systems. However, there are few systems that allow for in depth functional studies that include precise manipulation and interrogation of both microbiome composition and host function. Recently the nematode Caenorhabditis elegans - an excellent genetic model organism for studying many fields of biology, including neurobiology and behavior, development, cell biology, and innate immunity - has proven to be a robust system to probe microbiome interactions and their effect on host physiology.

Multi-Omics Responses In Tree Swallow (Tachycineta Bicolor) Nestlings From The Maumee Area Of Concern, Maumee River, Ohio, Chi Yen Tseng, Christine M. Custer, Thomas W. Custer, Paul M. Dummer, Natalie Karouna-Renier, Cole W. Matson

United States Geological Survey: Staff Publications

A multi-omics approach was utilized to identify altered biological responses and functions, and to prioritize contaminants to assess the risks of chemical mixtures in the Maumee Area of Concern (AOC), Maumee River, OH, USA. The Maumee AOC is designated by the United States Environmental Protection Agency as having significant beneficial use impairments, including degradation of fish and wildlife populations, bird or animal deformities or reproduction problems, and loss of fish and wildlife habitat. Tree swallow (Tachycineta bicolor) nestlings were collected at five sites along the Maumee River, which included wastewater treatment plants (WWTPs) and industrial land-use sites. Polychlorinated …

Middle Eastern And North African Immigrant Parents Caring For Obese Children: A Phenomenlogical Inquiry, Sadeg Aldolaim

Dissertations

Childhood obesity is one of the most serious public health challenges of the 21st century in the United States and worldwide. Several studies show that children with migrant backgrounds are more likely to be at risk of becoming obese. Obesity is associated with an increased risk of physical diseases and cognitive academic deficits in children and adolescents. The Middle Eastern and North African (MENA) population is one of the fastest-growing immigrant population groups in the United States. However, there are no studies exploring parental involvement in childhood obesity prevention programs among the MENA immigrant population.

The purpose of this qualitative …

Il-6 And Tnf-Α Responses To Acute And Regular Exercise In Adult Individuals With Multiple Sclerosis (Ms): A Systematic Review And Meta-Analysis, Parnian Shobeiri, Homa Seyedmirzaei, Nastaran Karimi, Fatemeh Rashidi, Antônio L Teixeira, Serge Brand, Dena Sadeghi-Bahmani, Nima Rezaei

Faculty, Staff and Student Publications

Background: In both the general population and people with multiple sclerosis (PwMS), physical exercise is associated with improved mental well-being. Moreover, there is evidence of the possible protection of physical activity against disease progression in multiple sclerosis (MS). However, the question arises if acute or regular exercise has any impact on the immune system in PwMS. To answer this question, we performed a systematic review and meta-analysis on both plasma and serum cytokine levels (IL-6 and TNF-α) before and after acute and regular exercise among PwMS and compared to healthy controls.

Method: We performed an online search via PubMed, EMBASE, …

#Golead Newsletter, Georgia Southern University

#GoLead Newsletter (2016-2023)

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Anthropogenic Contaminants In Glacial Environments Ii: Release And Downstream Consequences, Dylan B. Beard, Caroline C. Clason, Sally Rangecroft, Ewa Poniecka, Kim J. Ward, Will H. Blake

School of Geography, Earth and Environmental Sciences

Anthropogenic contamination has been detected in glacial and proglacial environments around the globe. Through mechanisms of secondary release, these contaminants are finding their way into glacial hydrological systems and downstream environments, with potential to impact hundreds of millions of people who rely on glacial meltwater for water, food and energy security worldwide. The first part of our progress report outlined the sources and accumulation mechanisms of contaminants in glacial environments (Part I: Inputs and accumulation). Here we assess processes of contaminant release, pathways to downstream environments, and socio-environmental consequences. We reflect on the potential impacts these contaminants could have for …

Reflections And Expressions, Lisa Blair

Journal of Conscious Evolution

No abstract provided.

Sars-Cov-2 Infection And Diabetes: Pathophysiological Mechanism Of Multi-System Organ Failure, Bipradas Roy, Sadia Afrin Runa

Hypertension and Vascular Research Articles

Since the discovery of the coronavirus disease 2019 outbreak, a vast majority of studies have been carried out that confirmed the worst outcome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in people with preexisting health conditions, including diabetes, obesity, hypertension, cancer, and cardiovascular diseases. Likewise, diabetes itself is one of the leading causes of global public health concerns that impose a heavy global burden on public health as well as socio-economic development. Both diabetes and SARS-CoV-2 infection have their independent ability to induce the pathogenesis and severity of multi-system organ failure, while the co-existence of these two culprits …

A Cbct Evaluation Of Esthetic Preference Regarding The Perceived Facial Attractiveness Of Young Korean Female Adults With A Normal Skeletal Pattern, Jin-Hyoung Oh, Jae H. Park, Heon J. Cho, Hye Y. Seo, Jong-Moon Chae

Pacific Faculty Work

The aim of this study was to determine the factors that affect esthetic preference regarding the perceived facial attractiveness of young Korean female adults with a normal skeletal pattern using cone-beam computed tomography (CBCT). After reorienting the CBCT images of 40 young Korean female adults, three-dimensional (3D) measurements were analyzed, and five 3D facial images were digitally constructed. A computer-based questionnaire was used to determine perceived facial attractiveness by scoring from 1 (very unattractive) to 10 (very attractive). Esthetic perception and the most influential facial view and component were examined and compared by orthodontists, general dentists, and laypeople to evaluate …

Genetic Variations Mir-10aa>T, Mir-30ca>G, Mir-181at>C, And Mir-499ba>G And The Risk Of Recurrent Pregnancy Loss In Korean Women, Hui-Jeong An, Sung-Hwan Cho, Han-Sung Park, Ji-Hyang Kim, Young-Ran Kim, Woo-Sik Lee, Jung-Ryeol Lee, Seong-Soo Joo, Eun-Hee Ahn, Nam-Keun Kim

Faculty, Staff and Student Publications

This study investigated the genetic association between recurrent pregnancy loss (RPL) and microRNA (miRNA) polymorphisms in miR-10aA>T, miR-30cA>G, miR-181aT>C, and miR-499bA>G in Korean women. Blood samples were collected from 381 RPL patients and 281 control participants, and genotyping of miR-10aA>T, miR-30cA>G, miR-181aT>C, and miR-499bA>G was carried out by TaqMan miRNA RT-Real Time polymerase chain reaction (PCR). Four polymorphisms were identified, including miR-10aA>T, miR-30cA>G, miR-181aT>C, and miR-499bA>G. MiR-10a dominant model (AA vs. AT + TT) and miR-499bGG genotypes were associated with increased RPL risk (adjusted odds ratio [AOR] = …

Clinical And Laboratory Evaluation Of Cholestatic Jaundice In A Sample Of Iraqi Infants, Yasir Nihad Noori, Ehab Ibrahim Rady

Muthanna Medical Journal

Cholestatic jaundice most probably occurs due to a pathological condition moreover difficult diagnostic problem. The aim of the study: to determine the etiology of cholestatic jaundice in infancy and to evaluate if clinical events and different investigations could assist in the differential diagnosis of intra and extra-hepatic cholestasis. In this hospital-based study analysis of 35 cases diagnosed with cholestatic jaundice aged 3 weeks up to 12 months from two centers carried out from January 2018 to July 2018. Clinical, biochemical, radiological, histopathological results were recorded. Results: Regarding the 35 patients were (54.3% males, 45.7% females), the mean age at presentation …

Consciousness, Evaluation, And The Self-Organizing Brain

Journal of Conscious Evolution

While evolution is guided by natural selection, it is internally driven by self-organizing processes. The brain encompasses these complementary forces and dynamics of evolution in both its structure and dynamics by embodying a historical record of the factors that have shaped it throughout its evolutionary past, as well as by being shaped by selective parameters in real time. Self-organization is evident in not only the brain’s structure and form, but also in the processes that support consciousness. From the convergence of complex structure and the novelty-generating dynamics of chaos that both characterize the brain arises the experience of explicit consciousness, …

Ecological Consequences Of Historic Moorland ‘Improvement’, Francis M. Rowney, Ralph M. Fyfe, Philip Anderson, Robert Barnett, William Blake, Tim Daley, Katie Head, Alison Macleod, Ian Matthews, David N. Smith

School of Geography, Earth and Environmental Sciences

No abstract provided.

A Framework For Studying Consciousness, Jeremy Horne

CONSCIOUSNESS: Ideas and Research for the Twenty-First Century

Scholars have wrestled with "consciousness", one writer calling it the "hard problem". Some thirty-plus years after the Towards a Science of Consciousness, we do not seem to be any closer to an answer to "What is consciousness?". Seemingly irresolvable metaphysical problems are addressed by bootstrapping, provisional assumptions, not unlike those used by logicians and mathematicians. I bootstrap with the same ontology and epistemology applicable to everything we apprehend. Here, I argue for a version of the unity of opposites, a form of neutral monism. Something exists because of what it is not; nothing can exist by itself, singularities (analogous to …

Silver Nanoparticles Formulation Of Flower Head’S Polyphenols Of Cynara Scolymus L.: A Promising Candidate Against Prostate (Pc-3) Cancer Cell Line Through Apoptosis Activation, Shady Swidan, Amgad Khedr, Marwa Goda, Abdelaziz Farrag, Ali Nasr, Mohamed Nafie, Maged Abdel-Kader, Jihan Badr, Reda Abdelhameed

Pharmacy

Cynara scolymus L. (Family: Compositae) or artichoke is a nutritious edible plant widely used for its hepatoprotective effect. Crude extracts of flower, bract, and stem were prepared and evaluated for their in vitro antioxidant activity and phenolic content. The flower crude extract exhibited the highest phenolic content (74.29 mg GAE/gm) as well as the best in vitro antioxidant activity using total antioxidant capacity (TAC), ferric reducing antioxidant power (FEAP), and 1,1-diphenyl-2-picrylhyazyl (DPPH) scavenging assays compared with ascorbic acid. Phenolic fractions of the crude extracts of different parts were separated and identified using high-performance liquid chromatography HPLC-DAD analysis. The silver nanoparticles …

Temperature Has A Unimodal Effect On The Functional Response Of Wolf Spiders, John Delong, Stella F. Uiterwaal, Alondra Magallanes

School of Biological Sciences: Faculty Publications

The response of biotic interactions to changes in temperature will play a large role in determining the impact of climate change on ecological communities. In particular, how warming alters predator-prey interactions will influence population stability, food web connectivity, and the movement of energy across trophic levels. The functional response relates predator foraging rates to prey availability, and it is often predicted to increase monotonically with temperature, at least within the limits of predator function. However, some studies suggest that functional responses peak and then decline, and such a difference has critical implications for the effect of warming on ecological communities. …

Temporal Lobe White Matter Asymmetry And Language Laterality In Epilepsy Patients, Nikolaos Soldatos, Huy Pham, Walid D Fakhouri, Binh Ngo, Panagiotis Lampropoulos, Tiffany Tran, Robin Weltman

Faculty, Staff and Student Publications

(1) Background: Several studies showed a sustained temperature of 47 °C or 50 °C for one minute resulted in vascular stasis and bone resorption with only limited bone regrowth over a 3–4-week healing period. The purpose of the present study was to evaluate the temperature changes (ΔΤ) that occur during the preparation of dental implant osteotomies using MIS® straight drills versus Densah® burs in a clockwise (cutting) drilling protocol. (2) Methods: Two hundred forty (240) osteotomies of two different systems’ drills were prepared at 6 mm depth at 800, 1000, and 1200 revolutions per minute (RPM), in fresh, unembalmed tibiae, …

Single-Cell Rna Transcriptome Analysis Of Cns Immune Cells Reveals Cxcl16/Cxcr6 As Maintenance Factors For Tissue-Resident T Cells That Drive Synapse Elimination, Sarah F Rosen, Allison L Soung, Wei Yang, Shenjian Ai, Marlene Kanmogne, Veronica A Davé, Maxim Artyomov, Jeffrey A Magee, Robyn S Klein

2020-Current year OA Pubs

BACKGROUND: Emerging RNA viruses that target the central nervous system (CNS) lead to cognitive sequelae in survivors. Studies in humans and mice infected with West Nile virus (WNV), a re-emerging RNA virus associated with learning and memory deficits, revealed microglial-mediated synapse elimination within the hippocampus. Moreover, CNS-resident memory T (T

METHODS: Here, we examined immune cells within the murine WNV-recovered forebrain using single-cell RNA sequencing to identify putative ligand-receptor pairs involved in intercellular communication between T cells and microglia. Clustering and differential gene analyses were followed by protein validation and genetic and antibody-based approaches utilizing an established murine model of …

To Kill A Mockingbird: A Look Into The Migratory Bird Treaty Act And Its Application To Unintentional Takings, Ben Davis

Oil and Gas, Natural Resources, and Energy Journal

No abstract provided.

Burdened, But Not Burdened Enough: A Long-Term Solution To The Difficulties Posed By Religious Objections To Resource Development, Nathan Downey

Oil and Gas, Natural Resources, and Energy Journal

No abstract provided.

Refining Terms For Small Refineries: The Extension Of Hardship Through Statutory Interpretation, Kylen Chase Huffman

Oil and Gas, Natural Resources, and Energy Journal

No abstract provided.

Positive Changes Made, Full Equality Not Achieved: Nc A&T State University In The Unc System And The Benefits It Received (1972-81), J. Charles Waldrup

Faculty Publications

No abstract provided.

The Bison, September 23, 2022

The Bison Newspapers

No abstract provided.

Volume Cxlii, Number 1, September 23, 2022, Lawrence University

The Lawrentian

No abstract provided.

Cancer As A Channelopathy—Appreciation Of Complimentary Pathways Provides A Different Perspective For Developing Treatments, Harry J. [email protected] Gould, Dennis Paul

School of Medicine Faculty Publications

Life depends upon the ability of cells to evaluate and adapt to a constantly changing environment and to maintain internal stability to allow essential biochemical reactions to occur. Ions and ion channels play a crucial role in this process and are essential for survival. Alterations in the expression of the transmembrane proteins responsible for maintaining ion balance that occur as a result of mutations in the genetic code or in response to iatrogenically induced changes in the extracellular environment is a characteristic feature of oncogenesis and identifies cancer as one of a constellation of diseases known as channelopathies. The classification …

Kenyon Collegiate - September 23, 2022

Kenyon Collegiate

No abstract provided.