Digital Commons Network^™

Prevention And Treatment Of Muscle Wasting With Ketone Supplementation, Andrew Paul Koutnik, Dominic Paul D'Agostino

USF Patents

Methods and compositions for treating or preventing muscle wasting resulting from an underlying disease or disorder, such as cancer cachexia. A therapeutically effective amount of a ketogenic supplement—such as R,S 1,3 butanediol diacetoacetate, R,S 1,3-butanediol acetoacetate diester, derivatives thereof, or combinations thereof—is administered to a patient or subject in need. The ketogenic supplement may further include a medium chain triglyceride in combination with the ketone ester.

The Ecology And Epidemiology Of Malaria Parasitism In Wild Chimpanzee Reservoirs, Erik J. Scully, Weimin Liu, Yingying Li, Jean-Bosco N. Ndjango, Martine Peeters, Shadrack Kamenya, Anne E. Pusey, Elizabeth V. Lonsdorf, Crickette M. Sanz, David B. Morgan, Alex K. Piel, Fiona A. Stewart, Mary K. Gonder, Nicole Simmons, Caroline Asiimwe, Klaus Zuberbuehler, Kathelijne Koops, Colin A. Chapman, Rebecca Chancellor, Aaron S. Rundus, Michael A. Huffman, Nathan D. Wolfe, Manoj T. Duraisingh, Beatrice H. Hahn, Richard W. Wrangham

Anthropology & Sociology Faculty Publications

Chimpanzees (Pan troglodytes) harbor rich assemblages of malaria parasites, including three species closely related to P. falciparum (sub-genus Laverania), the most malignant human malaria parasite. Here, we characterize the ecology and epidemiology of malaria infection in wild chimpanzee reservoirs. We used molecular assays to screen chimpanzee fecal samples, collected longitudinally and cross-sectionally from wild populations, for malaria parasite mitochondrial DNA. We found that chimpanzee malaria parasitism has an early age of onset and varies seasonally in prevalence. A subset of samples revealed Hepatocystis mitochondrial DNA, with phylogenetic analyses suggesting that Hepatocystis appears to cross species barriers more easily than Laverania. …

Comparative Study Of High-Performance Thin-Layer Chromatography And Antioxidant Potential Of Hydrocotyle Asiatica Mother Tincture Used In Homoeopathy, Rakhi Mishra, Binit Kumar Dwivedi, Deepshikha Gupta

Indian Journal of Research in Homoeopathy

Background: Hydrocotyle asiatica has a therapeutic significance in the Indian system of medicine due to its rich antioxidant activity. In Homoeopathy, Hydrocotyle asiatica is used for the treatment of jaundice, skin diseases, dropsy, elephantiasis, leprosy, gonorrhea, leucorrhea, and nervous debility. It contains the abundant triterpene glycoside Asiatic acid which shows cytotoxic activity on cancer cells. Its homoeopathic mother tincture is a major source of antioxidant compounds, which is responsible for its overall pharmacological activity.

Objectives: This study was done to evaluate antioxidant activity and High-Performance Thin-Layer Chromatography study of Hydrocotyle asiatica in-house homoeopathic mother tincture and market samples. …

Cholesterol Lowering Activity Of Homoeopathic Preparations Of Colchicum Autumnale – An In Vitro Study, Nithya T, Mansoor Ali Kr, Sheeba Veluthoor, U S Jijith, P Sithara Perveen, Afiya Alloor, Shijil V K

Indian Journal of Research in Homoeopathy

Background: Total cholesterol content of erythrocyte membranes plays a critical role in atherosclerotic plaque progression and instability. Several homoeopathic medicines are known to have a significant role in the control of hyperlipidaemia. Colchicum autumnale is a plant remedy used mainly for gout, but also for hyperlipidaemia.

Objectives: This is a study to assess the in vitro anti-cholesterol action of the Colchicum autumnale (Colch. at.) on the erythrocyte membrane. Materials and

Methods: The study was conducted using a hyperlipidaemic blood sample which was divided into eight parts. Six different potencies of Colch. at. were tested, and two controls, …

Homoeopathy In The Management Of Chronic Kidney Disease – A Narrative Review, Supriya Singh, Varanasi Roja, Khushboo Garg, Nisha Sehrawat, Jyotika Bhatti, Abhijit Chakma

Indian Journal of Research in Homoeopathy

Background: Chronic kidney disease (CKD) is the third fastest-growing cause of death around the world and is projected to become the fifth most common cause of years of life lost worldwide by 2040.

Objective: This review was done to explore the strengths of homoeopathy in the management of CKD through pre-clinical, clinical and anecdotal evidence.

Methods: A search was made for homoeopathic management of CKD in PubMed, Central Council for Research in Homoeopathy e-library, AYUSH Research Portal, EMBASE and Google Scholar. The basic search terms included ‘Homoeopathy’ or ‘homoeopathic drugs’, ‘ESRD’, ‘CRF’, ‘CKD’ and ‘Bright’s disease’. No …

Integration Of Mouse Ovary Morphogenesis With Developmental Dynamics Of The Oviduct, Ovarian Ligaments, And Rete Ovarii, Jennifer Mckey, Dilara N Anbarci, Corey Bunce, Alejandra E Ontiveros, Richard R Behringer, Blanche Capel

Faculty, Staff and Student Publications

Morphogenetic events during the development of the fetal ovary are crucial to the establishment of female fertility. However, the effects of structural rearrangements of the ovary and surrounding reproductive tissues on ovary morphogenesis remain largely uncharacterized. Using tissue clearing and lightsheet microscopy, we found that ovary folding correlated with regionalization into cortex and medulla. Relocation of the oviduct to the ventral aspect of the ovary led to ovary encapsulation, and mutual attachment of the ovary and oviduct to the cranial suspensory ligament likely triggered ovary folding. During this process, the rete ovarii (RO) elaborated into a convoluted tubular structure extending …

Transmission Roles Of Symptomatic And Asymptomatic Covid-19 Cases: A Modelling Study, Jianbin Tan, Yang Ge, Leonardo Martinez, Jimin Sun, Changwei Li, Adrianna Westbrook, Enfu Chen, Jinren Pan, Yang Li, Wei Cheng, Feng Ling, Zhinping Chen, Ye Shen, Hui Huang

Faculty Publications

Coronavirus disease 2019 (COVID-19) asymptomatic cases are hard to identify, impeding transmissibility estimation. The value of COVID-19 transmissibility is worth further elucidation for key assumptions in further modelling studies. Through a population-based surveillance network, we collected data on 1342 confirmed cases with a 90-days follow-up for all asymptomatic cases. An age-stratified compartmental model containing contact information was built to estimate the transmissibility of symptomatic and asymptomatic COVID-19 cases. The difference in transmissibility of a symptomatic and asymptomatic case depended on age and was most distinct for the middle-age groups. The asymptomatic cases had a 66.7% lower transmissibility rate than symptomatic …

Recent Emergence Of Bovine Coronavirus Variants With Mutations In The Hemagglutinin-Esterase Receptor Binding Domain In U.S. Cattle, Aspen M. Workman, Tara G. Mcdaneld, Gregory P. Harhay, Subha Das, John Dustin Loy, Benjamin M. Hause

School of Veterinary and Biomedical Sciences: Faculty Publications

Bovine coronavirus (BCoV) has spilled over to many species, including humans, where the host range variant coronavirus OC43 is endemic. The balance of the opposing activities of the surface spike (S) and hemagglutinin-esterase (HE) glycoproteins controls BCoV avidity, which is critical for interspecies transmission and host adaptation. Here, 78 genomes were sequenced directly from clinical samples collected between 2013 and 2022 from cattle in 12 states, primarily in the Midwestern U.S. Relatively little genetic diversity was observed, with genomes having >98% nucleotide identity. Eleven isolates collected between 2020 and 2022 from four states (Nebraska, Colorado, California, and Wisconsin) contained a …

Recent Emergence Of Bovine Coronavirus Variants With Mutations In The Hemagglutinin-Esterase Receptor Binding Domain In U.S. Cattle, Aspen M. Workman, Tara G. Mcdaneld, Gregory P. Harhay, Subha Das, John Dustin Loy, Benjamin M. Hause

School of Veterinary and Biomedical Sciences: Faculty Publications

Bovine coronavirus (BCoV) has spilled over to many species, including humans, where the host range variant coronavirus OC43 is endemic. The balance of the opposing activities of the surface spike (S) and hemagglutinin-esterase (HE) glycoproteins controls BCoV avidity, which is critical for interspecies transmission and host adaptation. Here, 78 genomes were sequenced directly from clinical samples collected between 2013 and 2022 from cattle in 12 states, primarily in the Midwestern U.S. Relatively little genetic diversity was observed, with genomes having >98% nucleotide identity. Eleven isolates collected between 2020 and 2022 from four states (Nebraska, Colorado, California, and Wisconsin) contained a …

Impad1 And Syt11 Work In An Epistatic Pathway That Regulates Emt-Mediated Vesicular Trafficking To Drive Lung Cancer Invasion And Metastasis, Rakhee Bajaj, B Leticia Rodriguez, William K Russell, Amanda N Warner, Lixia Diao, Jing Wang, Maria G Raso, Wei Lu, Khaja Khan, Luisa S Solis, Harsh Batra, Ximing Tang, Jared F Fradette, Samrat T Kundu, Don L Gibbons

Faculty, Staff and Student Publications

Lung cancer is a highly aggressive and metastatic disease responsible for approximately 25% of all cancer-related deaths in the United States. Using high-throughput in vitro and in vivo screens, we have previously established Impad1 as a driver of lung cancer invasion and metastasis. Here we elucidate that Impad1 is a direct target of the epithelial microRNAs (miRNAs) miR-200 and miR∼96 and is de-repressed during epithelial-to-mesenchymal transition (EMT); thus, we establish a mode of regulation of the protein. Impad1 modulates Golgi apparatus morphology and vesicular trafficking through its interaction with a trafficking protein, Syt11. These changes in Golgi apparatus dynamics alter …

The Effects Of Cannabidiol On Aqueous Humor Outflow And Trabecular Meshwork Cell Signaling., Alyssa S. Aebersold, Zhao-Hui Song

Faculty and Staff Scholarship

Intraocular pressure (IOP) is regulated primarily through aqueous humor production by ciliary body and drainage through uveoscleral and trabecular meshwork (TM) tissues. The goal of this study was to measure the effect of non-psychotropic cannabidiol (CBD) on aqueous humor outflow through TM and assess the effect of CBD on the TM cell signaling pathways that are important for regulating outflow. Perfused porcine eye anterior segment explants were used to investigate the effects of CBD on aqueous humor outflow. Cultured porcine TM cells were used to study the effects of CBD on TM cell contractility, myosin light chain (MLC) and myosin …

70 Years Of Dance: Copyrighting Choreography Since 1952, Annie Planker

Cardozo Arts & Entertainment Law Journal (AELJ) Blog

Choreography has long been a subject of controversy in the world of copyright. Despite its significance in the artistic community and the rise of social media in our everyday lives, choreography has not received the same property protections as other artforms, such as music, painting or sculpture. This is partly due to the transient nature of choreography; copyright law requires “fixed expressions” of works. It is also due to a legal hesitation to limit “social” arts. Lawmakers have little desire to prohibit large masses from participating in cultural activities.

This post was originally published on the Cardozo Arts & Entertainment …

Meeting The Challenges Of Myocarditis: New Opportunities For Prevention, Detection, And Intervention-A Report From The 2021 National Heart, Lung, And Blood Institute Workshop, Daniela Čiháková, Yang Shi, Bishow Adhikari, W Patricia Bandettini, Madeleine W Cunningham, Narasimhan Danthi, Matthias G Friedrich, Peter Liu, Lisa Schwartz Longacre, Douglas L Mann, Filip K Swirski, W H Wilson Tang, Guofei Zhou, Leslie T Cooper Jr., Workshop Speakers

2020-Current year OA Pubs

The National Heart, Lung, and Blood Institute (NHLBI) convened a workshop of international experts to discuss new research opportunities for the prevention, detection, and intervention of myocarditis in May 2021. These experts reviewed the current state of science and identified key gaps and opportunities in basic, diagnostic, translational, and therapeutic frontiers to guide future research in myocarditis. In addition to addressing community-acquired myocarditis, the workshop also focused on emerging causes of myocarditis including immune checkpoint inhibitors and SARS-CoV-2 related myocardial injuries and considered the use of systems biology and artificial intelligence methodologies to define workflows to identify novel mechanisms of …

A Glance On Severe Acute Respiratory Syndrome Coronavirus 2 (Sars Cov-2): A Brief Review, Marwa Mohammed Ali Jassim, Murtada Hafedh Hussein

Muthanna Medical Journal

Coronavirus disease 2019" is a highly contagious and infectious illness and cause globally acute upper respiratory systemic disease at latest 2019, major causing agent is "coronavirus-2" descent; also called "SARS COV-2". A "coronavirus" has a lower mortality in parallel with others, (SA.RS-CoV and ME.RS-CoV). In majority of people illness is in medium state; nevertheless, pneumonia may be developed, acute distress syndrome (AR.DS), and dysfunction in multiple organs (typically the aged and who having several other illness). many people are asymptomatic, while around 20% have moderate-to-severe illness. In current topic, can summarize the virologic basic of "coronavirus", which includes clinical features, …

Tauroursodeoxycholic Acid In Patients With Amyotrophic Lateral Sclerosis: The Tudca-Als Trial Protocol, Tudca-Als Study Group, Alberto Albanese, Albert Christian Ludolph, Christopher J. Mcdermott, Philippe Corcia, Philip Van Damme, Leonard H. Van Den Berg, Orla Hardiman, Gilberto Rinaldi, Nicola Vanacore, Brian Dickie, Paolo Tornese, Antoniangela Cocco, Maria Lo Giudice, Michela Matteoli, Eliana Lauranzano, Maria Luisa Malosio, Chiara Adriana Elia, Flavia Lombardo, Flavia Mayer, Maria Puopolo, Stefania Spila Alegiani, Adriano Chiò, Umberto Manera, Cristina Moglia, Andrea Calvo, Paolina Salamone, Giuseppe Fuda, Carlo Colosimo, Giuseppe Stipa, Domenico Frondizi, Christian Lunetta, Valeria Sansone, Claudia Tarlarini, Francesca Gerardi, Vincenzo Silani, Alberto Doretti, Eleonora Colombo, Gianluca Demirtzidis, Gioacchino Tedeschi, Francesca Trojsi, Carla Passaniti, Stefania Ballestrero, Johannes Dorst, Ulrike Weiland, Andrea Fromm, Maximilian Wiesenfarth, Katharina Kandler, Simon Witzel, Oliver Hanemann

Peninsula Medical School

Background: Amyotrophic lateral sclerosis (ALS) is a chronic neurodegenerative rare disease that affects motor neurons in the brain, brainstem, and spinal cord, resulting in progressive weakness and atrophy of voluntary skeletal muscles. Although much has been achieved in understanding the disease pathogenesis, treatment options are limited, and in Europe, riluzole is the only approved drug. Recently, some other drugs showed minor effects. Methods: The TUDCA-ALS trial is a phase III, multicenter, randomized, double-blind, placebo-controlled, parallel-group clinical trial. The study aims to enroll 320 patients in 25 centers across seven countries in Europe. Enrolled patients are randomized to one of two …

Blood-Brain Barrier Opening In A Large Animal Model Using Closed-Loop Microbubble Cavitation-Based Feedback Control Of Focused Ultrasound Sonication, Chih-Yen Chien, Lu Xu, Christopher Pham Pacia, Yimei Yue, Hong Chen

2020-Current year OA Pubs

Focused ultrasound (FUS) in combination with microbubbles has been established as a promising technique for noninvasive and localized Blood-brain barrier (BBB) opening. Real-time passive cavitation detection (PCD)-based feedback control of the FUS sonication is critical to ensure effective BBB opening without causing hemorrhage. This study evaluated the performance of a closed-loop feedback controller in a porcine model. Calibration of the baseline cavitation level was performed for each targeted brain location by a FUS sonication in the presence of intravenously injected microbubbles at a low acoustic pressure without inducing BBB opening. The target cavitation level (TCL) was defined for each target …

Cost Optimization Of Water Distribution Networks Without Storage Tanks, G. Ghali, Berge Djebedjian, Abdel-Rahim Dohina, Yahia M. Fouda

Mansoura Engineering Journal

This paper investigates the optimal design of water distribution networks without storage capacity using mathematical optimization. Both micro-genetic algorithm and hydraulic simulation of water network are used to find the optimal diameters of pipes of the network. The single-objective function of the optimization problem is the total cost of the capital costs of the piping network and the pump, and the operating cost of the pump, under the fulfillment of minimum nodal pressure requirements. An optimization methodology, Genetic Algorithm for Pumps (GAPUMPS), is used to minimize energy consumption. The described procedure is demonstrated in four case studies for water distribution …

Contributor Notes, Oakwood Staff

Oakwood

No abstract provided.

Cliff Senior; Myron, Cliff Taylor

Oakwood

No abstract provided.

Love In The Time Of Caldera, Todd Williams

Oakwood

No abstract provided.

The Museum Of Roadside Trash, Courtney Huse Wika

Oakwood

No abstract provided.

Gift Of Goats, Adam Luebke

Oakwood

No abstract provided.

Piano, J.D. Schraffenberger

Oakwood

No abstract provided.

Roadkill, J.D. Schraffenberger

Oakwood

No abstract provided.

Money, J.D. Schraffenberger

Oakwood

No abstract provided.

Perennial Warm-Season Grass Forages Impact On Cow-Calf Profitability In The Fescue Belt, Kyle A. Brazil, Patrick D. Keyser, Andrew P. Griffith, Christopher N. Boyer, J. Travis Mulliniks

Journal of Applied Farm Economics

Incorporating a perennial warm- season grass (WSG) into tall fescue (Lolium arundina-ceum [Schreb.] Darbysh.) forage systems in the fescue belt can help avoid the effects of fescue toxicosis on beef cattle (Bos taurus) reproduction and animal performance and provide forage during summer when fescue production is low. However, little information is available on the economics of incorporating WSG into fescue-based forage systems. We developed a simulation model to compare profitability of three forage systems—100% tall fescue, 70% tall fescue/30% bermudagrass (Cynodon dactylon), and 70% tall fescue/ 30% switchgrass (Panicum virgatum)—while also comparing spring- …

“Started By A Mouse” An Examination Into The Character Of Walt Disney, And The Company That He Built., Micah P. Bellamy

Bound Away: The Liberty Journal of History

Walt Disney's legacy reaches all over the world, which is a far stretch from his humble beginning delivering newspapers in Kansas City. This study will examine Walt Disney's life, starting with his humble beginnings on the farm, his early days as a cartoonist, to the rise of the Walt Disney Corporation. The examination will look at the man, Walt Disney, focusing on his upbringing and the various challenges that he faced throughout his life that shaped the leader that he would later become, and will reveal how, despite the adversities, obstacles, and challenges that Walt faced, and how they shaped …

The Rider (2022-09-26), Verilu Infante

The Rider Archives

Vol.8 No.5

Hawks' Herald -- Sep. 26, 2022, Roger Williams University

Hawk's Herald

No abstract provided.

Do You Know The Pathophysiology Of Cytokine Storm During Covid-19?, Shameera Shaik Masthan, Deekshitha Turaka, Ahmed Abdelhaleem, Mounica Vorla, Steven B. Lippmann

The University of Louisville Journal of Respiratory Infections

No abstract provided.