Digital Commons Network^™

Revisiting The Relation Between Syntax, Action, And Left Ba44, David L. Kemmerer

Purdue University Libraries Open Access Publishing Fund

Among the many lines of research that have been exploring how embodiment contributes to cognition, one focuses on how the neural substrates of language may be shared, or at least closely coupled, with those of action. This paper revisits a particular proposal that has received considerable attention—namely, that the forms of hierarchical sequencing that characterize both linguistic syntax and goal-directed action are underpinned partly by common mechanisms in left Brodmann area (BA) 44, a cortical region that is not only classically regarded as part of Broca’s area, but is also a core component of the human Mirror Neuron System. First, …

Development Of Phage Therapy Strategies Against Gram-Positive Bacterial Pathogens, Sara Arroyo Moreno

Theses

Bacterial resistance to conventional antibiotics has become an urgent healthcare issue worldwide. In this light, a renewed interest has emerged for therapy with bacteriophages (phages), which are viruses that can specifically infect bacteria. These viruses encode different proteins that degrade specific bonds within the bacterial cell wall, both to inject their genomic material into the bacterial cells and to release the viral progeny: virion-associated hydrolases and endolysins, respectively. Elimination of Gram-positive pathogens with recombinant versions of phage enzymes represents a promising alternative to classical antibiotics. In this thesis, different phage therapy strategies involving either whole phages or the use of …

Transcriptome Signatures Of Wastewater Effluent Exposure In Larval Zebrafish Vary With Seasonal Mixture Composition In An Effluent-Dominated Stream, Emma B. Meade, Luke R. Iwanowicz, Nicklaus Neureuther, Gregory H. Lefevre, Dana W. Kolpin, Hui Zhi, Shannon M. Meppelink, Rachael F. Lane, Angela Schmoldt, Aurash Mohaimani, Olaf Mueller, Rebecca D. Klaper

United States Geological Survey: Staff Publications

Wastewater treatment plant (WWTP) effluent-dominated streams provide critical habitat for aquatic and terrestrial organisms but also continually expose them to complex mixtures of pharmaceuticals that can potentially impair growth, behavior, and reproduction. Currently, few biomarkers are available that relate to pharmaceutical-specific mechanisms of action. In the experiment reported in this paper, zebrafish (Danio rerio) embryos at two developmental stages were exposed to water samples from three sampling sites (0.1 km upstream of the outfall, at the effluent outfall, and 0.1 km below the outfall) during base-flow conditions from two months (January and May) of a temperate-region effluent-dominated stream …

Spatial Patterns Of Woody Plant Encroachment In A Temperate Grassland, Dillon T. Fogarty, Robert B. Peterson, Dirac Twidwell

Department of Agronomy and Horticulture: Faculty Publications

Context Woody encroachment is the process whereby grasslands transition to a woody-dominated state. This process is a global driver of grassland decline and is ultimately the outcome of increased woody plant recruitment in grasslands. Yet, little is known about how recruitment distances structure spatial patterns of encroachment.

Objectives Here, we develop a recruitment curve to describe the scatter of woody plant recruitment around seed sources and examine how this structures spatial patterns of encroachment.

Methods We developed a recruitment curve for Juniperus virginiana using an encroachment dataset that captures spread from tree plantings into treeless grassland sites in the Nebraska …

Sga 54 Senate 2022-09-23 Minutes, Niu Student Government Association Senate

Student Government Association Archives

No abstract provided.

Chronic Illness Education 2022: Week In The Life Of Heart Health, Rebecca Schultz, Bria Elrod, Jacfar Hassan, Julia Chase, Keinnan Hares, Sadaf Hashemian

Patient Education Projects

No abstract provided.

To Bind Or Not To Bind: Cistromic Reprogramming In Prostate Cancer, Michelle Shen, Léa-Kristine Demers, Swneke D Bailey, David P Labbé

Faculty, Staff and Student Publications

The term "cistrome" refers to the genome-wide location of regulatory elements associated with transcription factor binding-sites. The cistrome of key regulatory factors in prostate cancer etiology are substantially reprogrammed and altered during prostatic transformation and disease progression. For instance, the cistrome of the androgen receptor (AR), a ligand-inducible transcription factor central in normal prostate epithelium biology, is directly impacted and substantially reprogrammed during malignant transformation. Accumulating evidence demonstrates that additional transcription factors that are frequently mutated, or aberrantly expressed in prostate cancer, such as the pioneer transcription factors Forkhead Box A1 (FOXA1), the homeobox protein HOXB13, and the GATA binding …

Autoaggregation Ability Of Diarrheal Causative Bacteria Isolated From Iraqi Children, Shahad Rashad Hameed

Muthanna Medical Journal

Stool samples were collected from 100 children patient aged between 3 days to 11 years who suffered from diarrhoea to isolate diarrheal causative bacteria. Fifty-one isolates were isolated and identified by cultural, microscopical, biochemical tests, and Vitek 2 system. The isolates were distributed as: 46 isolates belonged to Escherichia coli, 4 isolates belonged to Shigella sonnei, and one isolate belonged to Providencia alcalifaciens. All isolates were tested for antibiotic susceptibility to 10 different antibiotics and autoaggregation ability. All isolates were revealed resistant to Metronidazole while they were sensitive to Imipenem except one isolate of E. coli showed resistance to it. …

Advances In Non-Invasive Biosensing Measures To Monitor Wound Healing Progression, Walker D. Short, Oluyinka O. Olutoye, Benjamin W. Padon, Umang M. Parikh, Daniel Colchado, Hima Vangapandu, Shayan Shams, Taiyun Chi, Jangwook P. Jung, Swathi Balaji

Faculty Research, Scholarly, and Creative Activity

Impaired wound healing is a significant financial and medical burden. The synthesis and deposition of extracellular matrix (ECM) in a new wound is a dynamic process that is constantly changing and adapting to the biochemical and biomechanical signaling from the extracellular microenvironments of the wound. This drives either a regenerative or fibrotic and scar-forming healing outcome. Disruptions in ECM deposition, structure, and composition lead to impaired healing in diseased states, such as in diabetes. Valid measures of the principal determinants of successful ECM deposition and wound healing include lack of bacterial contamination, good tissue perfusion, and reduced mechanical injury and …

Micromorphology And Histology Of The Secretory Apparatus Of Diospyros Villosa (L.) De Winter Leaves And Stem Bark, Ot Adu, Yougasphree Naidoo, Ts Adu, Venkataramegowda Sivaram, Yaser Hassan Dewir, Hail Rihan

School of Biological and Marine Sciences

Diospyros villosa is a perennial species prominently acknowledged for its local medicinal applications. The native utilisation of this species in traditional medicine may be ascribed to the presence of secretory structures and their exudate (comprised of phytochemicals). However, the morphological nature and optical features of the secretory structures in D. villosa remain largely unclear. This study was directed to ascertain the occurrence and adaptive features of structures found within the leaves and stem bark of D. villosa using light and electron microscopy techniques. The current study notes the existence of trichomes, and other secretory structures were noted. SEM indicated the …

On A Novel Approach To The Thermogravimetric Analysis Of Polymers: Polystyrene, Mircea Chipara, Karen Lozano, Dorina M. Chipara, Carlos Delgado, Victoria Padilla

Physics & Astronomy Faculty Publications

A novel equation that describes the temperature dependence of the residual mass fraction (as determined by thermogravimetric analysis) is derived, assuming that the dependence of the residual mass fraction on temperature has a sigmoidal shape. The equation allows the estimation of the sigmoidal activation energy solely from the experimental data at a single heating rate. The consistency with the isoconversional approach and the relationship between the Ozawa and sigmoidal activation energies are reported. The equation was successfully tested by the thermal degradation of atactic polystyrene at various heating rates. Both the thermograms and their derivatives are analyzed in detail.

Non-Sedative Cortical Eeg Signatures Of Allopregnanolone And Functional Comparators, Peter M Lambert, Richard Ni, Ann Benz, Nicholas R Rensing, Michael Wong, Charles F Zorumski, Steven Mennerick

2020-Current year OA Pubs

Neurosteroids that positively modulate GABA

Islet Primary Cilia Motility Controls Insulin Secretion, Jung Hoon Cho, Zipeng A Li, Lifei Zhu, Brian D Muegge, Henry F Roseman, Eun Young Lee, Toby Utterback, Louis G Woodhams, Philip V Bayly, Jing W Hughes

2020-Current year OA Pubs

Primary cilia are specialized cell-surface organelles that mediate sensory perception and, in contrast to motile cilia and flagella, are thought to lack motility function. Here, we show that primary cilia in human and mouse pancreatic islets exhibit movement that is required for glucose-dependent insulin secretion. Islet primary cilia contain motor proteins conserved from those found in classic motile cilia, and their three-dimensional motion is dynein-driven and dependent on adenosine 5'-triphosphate and glucose metabolism. Inhibition of cilia motion blocks beta cell calcium influx and insulin secretion. Human beta cells have enriched ciliary gene expression, and motile cilia genes are altered in …

Parole Interview Transcript/Decision - Fusl000115 (2018-01-23)

Parole Interview Transcripts and Decisions

No abstract provided.

A Health Guard For Vr Gamer, Hp Inc

Defensive Publications Series

VR gaming is high concertation and immerse, so people is easy to forget his physical conditions. We usually got news that persons get sudden faint due to epilepsy or some dangerous physical condition while in metaverse. For this, we provide a health monitor and a method to help to protect user while he/she is in Metaverse. We detect local epileptic responses by measuring changes in the sympathetic nerve and body hormones and ions including adrenal corticosteroid, sodium ions, potassium ions and from the indicator to provide one algorithm to trigger the mitigate method to protect the user.

Phishing Detection Using Natural Language Processing And Machine Learning, Apurv Mittal, Dr Daniel Engels, Harsha Kommanapalli, Ravi Sivaraman, Taifur Chowdhury

SMU Data Science Review

Phishing emails are a primary mode of entry for attackers into an organization. A successful phishing attempt leads to unauthorized access to sensitive information and systems. However, automatically identifying phishing emails is often difficult since many phishing emails have composite features such as body text and metadata that are nearly indistinguishable from valid emails. This paper presents a novel machine learning-based framework, the DARTH framework, that characterizes and combines multiple models, with one model for each composite feature, that enables the accurate identification of phishing emails. The framework analyses each composite feature independently utilizing a multi-faceted approach using Natural Language …

Cov-Inception: Covid-19 Detection Tool Using Chest X-Ray, Aswini Thota, Ololade Awodipe, Rashmi Patel

SMU Data Science Review

Since the pandemic started, researchers have been trying to find a way to detect COVID-19 which is a cost-effective, fast, and reliable way to keep the economy viable and running. This research details how chest X-ray radiography can be utilized to detect the infection. This can be for implementation in Airports, Schools, and places of business. Currently, Chest imaging is not a first-line test for COVID-19 due to low diagnostic accuracy and confounding with other viral pneumonia. Different pre-trained algorithms were fine-tuned and applied to the images to train the model and the best model obtained was fine-tuned InceptionV3 model …

Application Of Probabilistic Ranking Systems On Women’S Junior Division Beach Volleyball, Cameron Stewart, Michael Mazel, Bivin Sadler

SMU Data Science Review

Women’s beach volleyball is one of the fastest growing collegiate sports today. The increase in popularity has come with an increase in valuable scholarship opportunities across the country. With thousands of athletes to sort through, college scouts depend on websites that aggregate tournament results and rank players nationally. This project partnered with the company Volleyball Life, who is the current market leader in the ranking space of junior beach volleyball players. Utilizing the tournament information provided by Volleyball Life, this study explored replacements to the current ranking systems, which are designed to aggregate player points from recent tournament placements. Three …

Assessing The Effectiveness Of The Mover Program For Treating Attention Deficit In Children (Mover: Movement Opportunities Through Vestibular Engagement Rhythm), Lindsay B. Williams, Camille Skubik-Peplaski

Student Journal of Occupational Therapy

Background: The purpose of this study was to investigate the effects of participation in a movement- to music program on the attention span of elementary school-aged children who have attention deficits. The hypothesis was that participants would demonstrate improved attention on the Test of Sustained Selective Attention (TOSSA) (Kovacs, 2015).

Methods: This quantitative study involved nine children who participated in four movement-to-music sessions with a staggered stop over a period of six weeks. The study incorporated a single group pre-test/post-test design, and a non-parametric Sign Test was utilized to analyze data from the TOSSA subcategories of concentration, detection, …

From Bad To Worse: The Clinical Spectrum Of Immune Checkpoint Inhibitor Myocarditis And Associated 3m Syndrome With Concomitant Myositis And Myasthenia, Tsun-Ho Lam, Jeffrey Sum-Lung Wong, Chun-Ka Wong, Gerry Gin Wai Kwok, Miaochang Zhou, Benjamin Yu-Fai So, Ian Yu-Hin Leung, Hung-Fat Tse

Journal of the Hong Kong College of Cardiology

Immune checkpoint inhibitors (ICIs), though revolutionizing cancer care, are well known to cause a diverse array of autoimmune side effects termed immune-related adverse events (IRAEs). ICI Myocarditis is a rare manifestation of IRAE associated with high mortality. We report two cases of fulminant ICI myocarditis refractory to potent immunosuppressants. Our first patient received pembrolizumab for lymphoma, small cell lung cancer and renal cell carcinoma. After 13 doses of ICIs, he developed fulminant myocarditis with concomitant lower-motor neuron type facial nerve palsy. Despite receiving triple immunosuppressive therapies with pulse steroid, mycophenolate mofetil and basiliximab, his cardiac condition progressively worsened and eventually …

The Chanticleer, 2022-09-22, Coastal Carolina University

The Chanticleer Student Newspaper

The editorially independent student produced weekly newspaper of Coastal Carolina University.

Issue 403: September 22-October 6, 2022, The Local Voice

The Local Voice

No abstract provided.

Prince Hamlet, Office Of Arts + Cultural Programming, Peak Performances At Montclair State University

2022-2023 Artists Invoke the Powers of Community as They Bring Audiences Into Fiery, Mysterious, Illuminating Visions of Our World

Ravi Jain’s remixed, reimagined, and bilingual Prince Hamlet features a cross-cultural, gender-bent cast – challenging traditional ideas of who can tell this story. Interweaving Shakespeare’s spoken text with heightened and poetic American Sign Language, this groundbreaking production creates a visually stunning retelling for both hearing and Deaf audiences. You’ve never experienced Hamlet like this before.

Embracing The Subjunctive Voice: An Analytic For Ecologically Uncertain Times, Katherine D. Lind

Communication Studies Faculty Works

In this article, I assess viral videos depicting environmental crises and species loss, theorizing the “eco-subjunctive voice” as a rhetorically productive perspective for engaging extinction imagery. Building on Barbie Zelizer’s notion of the “subjunctive voice” in images, I explore how viral videos of a polar bear and a sea turtle in jeopardy unite despair and hopefulness, strategically deploy “about-to-die” moments, and make the “hyperobjects” of climate catastrophe more intelligible. Additionally, an ecosubjunctive reading of each video demonstrates the limits of the synecdochic logic commonly employed in ecological discourse. The eco-subjunctive voice is an analytic useful for academics, activists, and audiences. …

The Student Movement Volume 107 Issue 2: We Prayed, We Changed, We Glowed: Week Three At Andrews University, Gloria Oh, Grace No, Lauren Kim, Skyler Campbell, Solana Campbell, Andrew Francis, Yoel Kim, Rachel Ingram-Clay, Terika Williams, Genevieve Prouty, Elizabeth Dovich, Charisse Lapuebla, Desmond Hartwell Murray, Melissa Moore, Alannah Tjhatra

The Student Movement v. 107 (2022-2023)

HUMANS

Change Day Interview: Jessica Bowen, Interviewed by: Gloria Oh

Interview with Brandon Alvarez, Interviewed by: Grace No

Meet Andrew Rappette, AUSA Executive Vice President, Interviewed by: Lauren Kim

ARTS & ENTERTAINMENT

Change Day: Art as a Service, Skyler Campbell

Currently..., Solana Campbell

Disney's D23 Expo Concludes, Andrew Francis

In the Rick of Time: Season 6 Launces Off My 2022 School Year, Grace No

NEWS

Almost Anything Goes, Glow Edition, Yoel Kim & Editors

Lead Levels in Benton Harbor, Abigail Kim

Students React to Queen Elizabeth's Passing, Andrew Francis

IDEAS

iOS 16 and the new iPhone: Bop or Flop?, Rachel …

Book Review Of Clamouring For Legal Protection: What The Great Books Teach Us About People Fleeing From Persecution, Cori Alonso-Yoder

Journal of Legal Education

No abstract provided.

The Evolving Mission Of Peking University’S School Of Transnational Law, Philip J. Mcconnaughay

Journal of Legal Education

No abstract provided.

Engineering Sars-Cov-2 Specific Cocktail Antibodies Into A Bispecific Format Improves Neutralizing Potency And Breadth, Zhiqiang Ku, Xuping Xie, Jianqing Lin, Peng Gao, Bin Wu, Abbas El Sahili, Hang Su, Yang Liu, Xiaohua Ye, Eddie Yongjun Tan, Xin Li, Xuejun Fan, Boon Chong Goh, Wei Xiong, Hannah Boyd, Antonio E Muruato, Hui Deng, Hongjie Xia, Jing Zou, Birte K Kalveram, Vineet D Menachery, Ningyan Zhang, Julien Lescar, Pei-Yong Shi, Zhiqiang An

Faculty, Staff and Student Publications

One major limitation of neutralizing antibody-based COVID-19 therapy is the requirement of costly cocktails to reduce emergence of antibody resistance. Here we engineer two bispecific antibodies (bsAbs) using distinct designs and compared them with parental antibodies and their cocktail. Single molecules of both bsAbs block the two epitopes targeted by parental antibodies on the receptor-binding domain (RBD). However, bsAb with the IgG-(scFv)2 design (14-H-06) but not the CrossMAb design (14-crs-06) shows increased antigen-binding and virus-neutralizing activities against multiple SARS-CoV-2 variants as well as increased breadth of neutralizing activity compared to the cocktail. X-ray crystallography and cryo-EM reveal distinct binding models …

Parental Tuning Of Language Input To Autistic And Nonspectrum Children, Angela Xiaoxue He, Rhiannon Luyster, Sudha Arunachalam

Emerson Authors, Researchers, & Creators

Caregivers’ language input supports children’s language development, and it is often tuned to the child’s current level of skill. Evidence suggests that parental input is tuned to accommodate children’s expressive language levels, but accommodation to receptive language abilities is less understood. In particular, little is known about parental sensitivity to children’s abilities to process language in real time. Compared to nonspectrum children, children on the spectrum are slower to process language. In this study, we ask: Do parents of autistic children and those of nonspectrum children tune their language input to accommodate children’s different language processing abilities? Children with and …

Topical Application Of An Irreversible Small Molecule Inhibitor Of Lysyl Oxidases Ameliorates Skin Scarring And Fibrosis, Nutan Chaudhari, Alison D. Findlay, Andrew W. Stevenson, Tristan D. Clemons, Yimin Yao, Amar Joshi, Sepidar Sayar, Gordon Wallace, Suzanne Rea, Priyanka Toshniwal, Zhenjun Deng, Philip E. Melton, Nicole Hortin, K. Swaminathan Iyer, Wolfgang Jarolimek, Fiona M. Wood, Mark W. Fear

Faculty Publications

Scarring is a lifelong consequence of skin injury, with scar stiffness and poor appearance presenting physical and psychological barriers to a return to normal life. Lysyl oxidases are a family of enzymes that play a critical role in scar formation and maintenance. Lysyl oxidases stabilize the main component of scar tissue, collagen, and drive scar stiffness and appearance. Here we describe the development and characterisation of an irreversible lysyl oxidase inhibitor, PXS-6302. PXS-6302 is ideally suited for skin treatment, readily penetrating the skin when applied as a cream and abolishing lysyl oxidase activity. In murine models of injury and fibrosis, …