Digital Commons Network^™

Impact Of Dietary Walnuts, A Nutraceutical Option, On Circulating Markers Of Metabolic Dysregulation In A Rodent Cachectic Tumor Model, Lauri O. Byerley, Hsiao Man Chang, Brittany Lorenzen, Jessie Guidry, W. Elaine Hardman

School of Medicine Faculty Publications

Background: Nutraceutical foods, like walnuts which are rich in immunonutrients, can have medicinal benefits. Dietary walnuts have been shown to slow or prevent tumor growth in mice genetically programmed to grow breast or prostate tumors. This study investigated whether walnuts could exert the same preventable effect in a transplantable carcinoma rat model. Methods: Eighteen rats were randomly fed a diet containing walnuts (10% of food by weight), and 36 were fed a diet without walnuts (control) for 21 days. On day 22, 18 control diet rats were switched to the walnut diet. All other animals remained on their same diet. …

November 2022 News Releases, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.

Improving Experience Of Medical Abortion At Home In A Changing Therapeutic, Technological And Regulatory Landscape: A Realist Review, P Baraitser, C Free, Wv Norman, M Lewandowska, R Meiksin, Mj Palmer, R Scott, R French, K Wellings, A Ivory, G Wong

More Faculty of Health Research

Objective. To inform UK service development to support medical abortion at home, appropriate for person and context. Design. Realist review Setting/participants Peer-reviewed literature from 1 January 2000 to 9 December 2021, describing interventions or models of home abortion care. Participants included people seeking or having had an abortion. Interventions. Interventions and new models of abortion care relevant to the UK. Outcome measures. Causal explanations, in the form of context-mechanism-outcome configurations, to test and develop our realist programme theory. Results. We identified 12 401 abstracts, selecting 944 for full text assessment. Our final review included 50 papers. Medical abortion at home …

Quantifying Pain: A Ratio Of Cortisol, Substance P, And Pituitary Adenylate Cyclase-Activating Polypeptide As Biomarkers For Pain In Animal Cruelty And Neglect, Danielle Sherer

Master's Theses

Understanding the relationship between cortisol, Substance P, and PACAP during experienced pain and recovery, as well as the contrast between expression levels and serum levels, will provide an objective measure of pain and suffering to aid in the prosecution of animal cruelty and neglect cases.

There is no consensus at this time as to a recognized biomarker for pain experienced by an animal. Cortisol, Substance P, and Pituitary Adenylate Cyclase-Activating Peptide (PACAP) have been investigated separately in various animal and human studies with regard to stress, pain, and injury. Cortisol is a steroid hormone in the glucocorticoid class that has …

Tracey In The 16th Minute, Timothy Poisson, Tim Fish

Dartmouth College Master’s Theses

The COVID-19 pandemic of 2020 has engaged millions of individuals in an existential crisis of values and purpose, echoing throughout “the Great Resignation,” in which 45% or more of Americans have been actively seeking new employment and change in lifestyle (Backman).

Walter Kaufmann’s question and answer,

…could it be that at least some part of what the existentialists attempt to do is best done in art and not philosophy? …at some given time and place one of the arts …says more adequately what the others say less well (Kaufmann 49),

inspires this thesis project—in the form of a screenplay—to answer …

Assessing Urinary Phenol And Paraben Mixtures In Pregnant Women With And Without Gestational Diabetes Mellitus: A Case-Control Study, Wei-Jen Chen, Candace Robledo, Erin M Davis, Jean R Goodman, Chao Xu, Jooyeon Hwang, Amanda E Janitz, Tabitha Garwe, Antonia M Calafat, Jennifer D Peck

Faculty, Staff and Student Publications

Prior studies have identified the associations between environmental phenol and paraben exposures and increased risk of gestational diabetes mellitus (GDM), but no study addressed these exposures as mixtures. As methods have emerged to better assess exposures to multiple chemicals, our study aimed to apply Bayesian kernel machine regression (BKMR) to evaluate the association between phenol and paraben mixtures and GDM. This study included 64 GDM cases and 237 obstetric patient controls from the University of Oklahoma Medical Center. Mid-pregnancy spot urine samples were collected to quantify concentrations of bisphenol A (BPA), benzophenone-3, triclosan, 2,4-dichlorophenol, 2,5-dichlorophenol, butylparaben, methylparaben, and propylparaben. Multivariable …

Clinical Significance And Potential Role Of Trimethylamine N-Oxide In Neurological And Neuropsychiatric Disorders, Sowjanya Mudimela, Narahari Koppa Vishwanath, Anilkumar Pillai, Rodrigo Morales, Sean P Marrelli, Tatiana Barichello, Vijayasree V Giridharan

Faculty, Staff and Student Publications

Research in the last three decades has attracted the attention of many scientists and industrialists on the gut microbiome and its metabolites. Among many of these metabolites, trimethylamine oxide. Dietary choline, phosphatidylcholine, carnitine, and betaine produces TMAO that with other gut metabolites such as TMA (trimethylamine), and short-chain fatty acids (SCFA) enter the circulation. Finally they reach the brain through the blood-brain barrier (BBB) where they are involved in several physiological functions such as brain development, neurogenesis, and behavior. Gut-microbiota composition is influenced by diet, lifestyle, antibiotics, and age resulting in dysbiosis. Several studies have confirmed that altered TMAO levels …

The Romantic Author As Compelled Speaker, Sonya G. Bonneau

Georgetown Law Faculty Publications and Other Works

The romantic author trope has been extensively criticized in the copyright context, yet it threatens to emerge as a new pillar of First Amendment compelled speech jurisprudence. Justice Thomas’s concurring opinion in Masterpiece Cakeshop v. Colorado Civil Rights Commission exemplifies the trope’s rhetorical power, and the costs of that approach. Casting the baker as an artist, Justice Thomas finds that creating custom wedding cakes was speech, and that applying a public accommodations law to require service to a same-sex couple triggered strict scrutiny review. This is an extraordinary result. Although the Court never adjudicated the compelled speech claim, it will …

Asking The Right Questions To Solve Algebraic Word Problems, Ege Yi̇ği̇t Çeli̇k, Zeynel Orulluoğlu, Ridvan Mertoğlu, Selma Teki̇r

Turkish Journal of Electrical Engineering and Computer Sciences

Word algebra problems are among challenging AI tasks as they combine natural language understanding with a formal equation system. Traditional approaches to the problem work with equation templates and frame the task as a template selection and number assignment to the selected template. The recent deep learning-based solutions exploit contextual language models like BERT and encode the natural language text to decode the corresponding equation system. The proposed approach is similar to the template-based methods as it works with a template and fills in the number slots. Nevertheless, it has contextual understanding because it adopts a question generation and answering …

Primary Failure Of Tooth Eruption: Etiology And Management, Tetsutaro Yamaguchi, Kazuyoshi Hosomichi, Tatsuo Shirota, Yoichi Miyamoto, Wanida Ono, Noriaki Ono

Faculty, Staff and Student Publications

Primary failure of eruption (PFE) is a rare disorder defined as incomplete tooth eruption despite the presence of a clear eruption pathway. PFE is known to be caused by rare variants in the parathyroid hormone 1 receptor gene (PTH1R). Although several PTH1R variants have been reported, the etiology of PFE remains unclear. However, important studies that help elucidate the pathology of PFE have recently been published. The purpose of this review is to summarize current treatment options, clinical symptoms or phenotypes for diagnosis, genetic information including solid evidence in mouse disease models and disease-specific induced pluripotent stem cells, …

Testing And Verification For The Open Source Release Of The Horizon Simulation Framewortesting And Verification For The Open Source Release Of The Horizon Simulation Framework, William J. Balfour

Master's Theses

Modeling and simulation tools are exceptionally useful for designing aerospace systems because they allow engineers to test and iterate designs before committing the massive resources required for system realization. The Horizon Simulation Framework (HSF) is a time-driven modeling and simulation tool which attempts to optimize how a modeled system could perform a mission profile. After 15 years of development, the HSF team aims to achieve a wider user and developer base by releasing the software open source. To ensure a successful release, the software required extensive testing, and the main scheduling algorithm required protections against new code breaking old functionality. …

Chitosan Nanogel With Mixed Food Plants And Its Relation To Blood Glucose In Type 2 Diabetes: A Systematic And Meta-Analysis Review Of Observational Studies, Morris Aloysius, Kyriacos N. Felekkis, Christos Petrou, Dimitrios Papandreou, Eleni Andreou

All Works

This systematic review with metanalysis evaluated and analyzed the beneficial effects of certain plants food in type 2 diabetes (T2D) when consumed alone or in combination with chitosan. The main objective of the paper was to examine the relation of chitosan nanogel and mixed food plant (MFP) to control T2D. The databases included Medline, Scopus, PubMed, as well as Cochrane available between the month of January 1990 to January 2021. The eligibility criteria for selecting studies were case-controlled studies that included unripe plantain, bitter yam, okra, and chitosan either used-alone or in combination with non-specified food plants (NSFP). Two-fold autonomous …

Rsif Tanzania Country Report 2022, Rsif In Tanzania 2022

Rsif Country Progress Reports

Tanzania is part of PASET and has expressed its intention to contribute to Rsif. There are 11 competitively selected Tanzanian Rsif PhD students (73% women) in four thematic areas in four different African Host Universities. Two Tanzanian universities were competitively selected as Rsif African host universities: Sokoine University of Agriculture in Food security and agribusiness in 2017 and Nelson Mandela African Institution of Science and Technology, (NM-AIST) in mineral, mining and material science in 2019. They are hosting a total of 60 Rsif PhD students from 20 different nationalities with 50 publications in high impact journals to date. There are …

Atrial Fibrillation With Controlled Ventricular Rate And New-Onset Heart Failure: Atypical Presentation, Worse Prognosis, Vinay Mehta, Alexander Albers, Maharaj Singh, Timothy E. Paterick

College of Nursing Faculty Research and Publications

Background: There is deficient literature comparing patients with atrial fibrillation (AF) who present with rapid ventricular rate (RVR) versus controlled ventricular rate (CVR) associated with new-onset heart failure.

Purpose: This study aimed to evaluate patients with new-onset cardiomyopathy (CM) and a concomitant or preceding history of AF and compare patients with CVR (≤100 bpm) to those with RVR (>100 bpm).

Methods: Patients with newly diagnosed CM, defined as a left ventricular ejection fraction ≤40%, were identified from our healthcare database and divided into two groups: those with a ventricular rate ≤100 bpm (CVR-CM, n=79) and those with a ventricular …

Period, Break, Form, David Sergeant

School of Law, Humanities and Social Sciences

This essay examines the relationship between novelistic form and a historical moment shaped by new technologies in Dave Eggers's The Circle (2013) and Kim Stanley Robinson's Red Moon (2018). In both, the novel form is itself positioned as a major counterforce against the malignant powers that are attempting to form the age. Also in both, new technologies are understood not as primary or independent shaping forces but as enabling components of a larger political and economic form, a variant of capitalism. However, the crucial difference between the two novels is in how they periodize this capitalism, an act that is …

An Improved Bio-Based Activated Carbon For The Water Treatment Of A Lagoon In Northern Mexico Based On Life Cycle Assessment Methodology, Leticia Elizabeth Rodriguez

Open Access Theses & Dissertations

In this research, different options in the preparation of activated carbon are investigated looking at potential environmental impacts, production cost improvement and physical characteristics for water treatment. The activated carbon made with agricultural waste is compared to activated carbon made with hard coal. Life cycle assessment techniques follow ISO 14040 to 14044 standards are used and calculations were performed using GaBi _education 18® software and databases at mid-point TRACI impact categories. The results of the life cycle impact assessment show that, compared to activated carbon made with hard coal, activated carbon made with peanut shell and rice husk allows reductions …

Tennessee Farm Bureau News - November 2022, Tennessee Farm Bureau Federation

Tennessee Farm Bureau News

No abstract provided.

Microfibers: Environmental Problems And Textile Solutions, Js Weis, Francesca De Falco

School of Geography, Earth and Environmental Sciences

Microplastics have become a topic of considerable concern and intensive study over the past decade. They have been found everywhere in the oceans, including the deepest trenches and remotest parts of the Arctic. They are ingested by many animals and some are incorporated into tissues. There is considerable effort in studying what effects they have on marine life. It has become clear that when water samples are collected in ways that prevent most long thin particles from escaping through pores of a net, the most abundant type of microplastics found in water and sediments are microfibers (fibers with dimensions less …

Lactic Acid Bacteria Isolated From Fresh Vegetable Products: Potential Probiotic And Postbiotic Characteristics Including Immunomodulatory Effects, Fatima Khaled Alameri

Theses

The ability to perform effectively in the gastrointestinal system (GIT) is one of the most significant criteria for selecting the best probiotic bacteria. Thus, the present study aimed to investigate the potential probiotic characteristics of some selected lactic acid bacteria (LAB) isolated from vegetable products. Probiotic characteristics included tolerance to acid and bile, cholesterol removing ability, bile salt hydrolysis, resistance against lysozyme and antibiotics, production of exopolysaccharides (EPS), antimicrobial and hemolytic activities, and cell surface characteristics (auto-aggregation, co-aggregation, and hydrophobicity). Out of 46 isolates, 17 isolates that exhibited remarkable survivability under gastrointestinal conditions were selected for further analysis. Almost all …

Distribution Of Erm Proteins In The Stomach Mucosa Of Normal And Diabetic Rats, Asmaa Salem Al Sereidi

Theses

Diabetes mellitus (DM), or simply diabetes, refers to a group of metabolic disorders that include a variety of diseases that disrupt our body's metabolism. The long-term uncontrolled disease can lead to stomach complications such as gastroparesis, as well as disruption in several proteins, such as ERM (Ezrin, radixin, moesin) proteins. ERM proteins are three proteins that are structurally and functionally related. ERM proteins have molecular masses of 82, 80, and 75 kDa, respectively. Ezrin is highly expressed in the stomach, especially in parietal cells that secrete gastric acid. ERM proteins function as scaffolding proteins in lipid rafts and granule trafficking …

Utilizing Date Pits In Microencapsulation: Effect Of Different Variations On Probiotic Survivability Under In Vitro Digestion, Asmaa Samir Al Hamayda

Theses

This work deals with the medicinal use of date pit powder, which turns it from a waste product to a useful stabilizer for the release of beneficial probiotics in the human intestine. The main objective of this work is to encapsulate probiotics with date pit beads and their subsequent release in the human intestine. The beads were formed using gravitational dripping technique, while INFOGEST protocol was used to test the digested beads and the release of viable probiotic cells. For the three date varieties Raziz, Naghal and Khadrawy, it was found that 0.1 g of date pit powder per 0.2 …

Identifying Early-Life Behavior To Predict Mothering Ability In Swine Utilizing NuTrack System, Savannah Gabrielle Millburn

Department of Animal Science: Dissertations, Theses, and Student Research

Early recognition of indicator traits for swine reproduction and longevity supports economical selection decision making. Gilt activity is a key variable impacting a sow’s herd life and productivity. The purpose of this study was to examine early- life behaviors contributing to farrowing traits including gestation length (GL), number born alive (NBA), number weaned (NW), and herd life (HL). Herd life was a binary trait representing if a gilt was culled after one parity. Beginning at approximately 20 weeks of age, video recordings were taken on 480 gilts for 7 consecutive days and processed using the NUtrack system. Activity traits …

Hill Climbing-Based Efficient Model For Link Prediction In Undirected Graphs, Haji Gul, Feras Al-Obeidat, Adnan Amin, Fernando Moreira, Kaizhu Huang

All Works

Link prediction is a key problem in the field of undirected graph, and it can be used in a variety of contexts, including information retrieval and market analysis. By “undirected graphs”, we mean undirected complex networks in this study. The ability to predict new links in complex networks has a significant impact on society. Many complex systems can be modelled using networks. For example, links represent relationships (such as friendships, etc.) in social networks, whereas nodes represent users. Embedding methods, which produce the feature vector of each node in a graph and identify unknown links, are one of the newest …

Potential Focal Adhesion Kinase Inhibitors In Management Of Cancer: Therapeutic Opportunities From Herbal Medicine, Feiyu Chen, Zhangfeng Zhong, Cheng Zhang, Yuanjun Lu, Yau-Tuen Chan, Ning Wang, Di Zhao, Yibin Feng

Faculty, Staff and Student Publications

Focal adhesion kinase (FAK) is a multifunctional protein involved in cellular communication, integrating and transducing extracellular signals from cell-surface membrane receptors. It plays a central role intracellularly and extracellularly within the tumor microenvironment. Perturbations in FAK signaling promote tumor occurrence and development, and studies have revealed its biological behavior in tumor cell proliferation, migration, and adhesion. Herein we provide an overview of the complex biology of the FAK family members and their context-dependent nature. Next, with a focus on cancer, we highlight the activities of FAK signaling in different types of cancer and how knowledge of them is being used …

Advances In Understanding Cancer-Associated Neurogenesis And Its Implications On The Neuroimmune Axis In Cancer, Ismail Yaman, Didem Ağaç Çobanoğlu, Tongxin Xie, Yi Ye, Moran Amit

Faculty, Staff and Student Publications

Nerves and immunologic mediators play pivotal roles in body homeostasis by interacting with each other through diverse mechanisms. The spread of nerves in the tumor microenvironment increases tumor cell proliferation and disease progression, and this correlates with poor patient outcomes. The effects of sympathetic and parasympathetic nerves on cancer regulation are being investigated. Recent findings demonstrate the possibility of developing therapeutic strategies that target the tumor microenvironment and its components such as immune cells, neurotransmitters, and extracellular vesicles. Therefore, examining and understanding the mechanisms and pathways associated with the sympathetic and parasympathetic nervous systems, neurotransmitters, cancer-derived mediators and their interactions …

Effects Of Genotype And Food On Naltrexone Exposure In Adolescents., Stephani L. Stancil, Michaela Voss, Whitney M. Nolte, John Tumberger, William Adelman, Susan Abdel-Rahman

Manuscripts, Articles, Book Chapters and Other Papers

Naltrexone (NTX), an opioid antagonist metabolized by aldo-keto reductase 1C4 (AKR1C4), is prescribed for psychiatric conditions like eating disorders with variable response. Systemic exposure is highly variable in adults, yet no data exist in children. The purpose of this study was to evaluate NTX exposure in adolescents with eating disorders. Adolescents aged 12-21 years with eating disorders underwent postdose blood sampling in the fasted and/or fed state. NTX and primary active metabolite, 6-β-naltrexol, were determined by ultra-high performance liquid chromatography tandem mass spectrometry. Pharmacokinetic parameters were determined by noncompartmental analysis. DNA was genotyped for AKR1C4 missense mutations associated with decreased …

Handwashing Results In Incomplete Nicotine Removal From Fingers Of Individuals Who Smoke: A Randomized Controlled Experiment, Thomas F Northrup, Angela L Stotts, Robert Suchting, Amir M Khan, Michelle R Klawans, Charles Green, Eunha Hoh, Melbourne F Hovell, Georg E Matt, Penelope J E Quintana

Faculty, Staff and Student Publications

Objective: Tobacco residue, also known as third-hand smoke (THS), contains toxicants and lingers in dust and on surfaces and clothes. THS also remains on hands of individuals who smoke, with potential transfer to infants during visitation while infants are hospitalized in neonatal intensive care units (NICUs), raising concerns (e.g., hindered respiratory development) for vulnerable infants. Previously unexplored, this study tested handwashing (HW) and sanitization efficacy for finger-nicotine removal in a sample of adults who smoked and were visiting infants in an NICU.

Study design: A cross-sectional sample was recruited to complete an interview, carbon monoxide breath samples, and three nicotine …

Is Loss Of P53 A Driver Of Ductal Carcinoma In Situ Progression?, Rhiannon L Morrissey, Alastair M Thompson, Guillermina Lozano

Faculty, Staff and Student Publications

Ductal carcinoma in situ (DCIS) is a non-obligate precursor of invasive carcinoma. Multiple studies have shown that DCIS lesions typically possess a driver mutation associated with cancer development. Mutation in the TP53 tumour suppressor gene is present in 15-30% of pure DCIS lesions and in ~30% of invasive breast cancers. Mutations in TP53 are significantly associated with high-grade DCIS, the most likely form of DCIS to progress to invasive carcinoma. In this review, we summarise published evidence on the prevalence of mutant TP53 in DCIS (including all DCIS subtypes), discuss the availability of mouse models for the study of DCIS …

Rad Regulation Of Cav12 Channels Controls Cardiac Fight-Or-Flight Response, Arianne Papa, Sergey I Zakharov, Alexander N Katchman, Jared S Kushner, Bi-Xing Chen, Lin Yang, Guoxia Liu, Alejandro Sanchez Jimenez, Robyn J Eisert, Gary A Bradshaw, Wen Dun, Shah R Ali, Aaron Rodriques, Karen Zhou, Veli Topkara, Mu Yang, John P Morrow, Emily J Tsai, Arthur Karlin, Elaine Wan, Marian Kalocsay, Geoffrey S Pitt, Henry M Colecraft, Manu Ben-Johny, Steven O Marx

Faculty, Staff and Student Publications

Fight-or-flight responses involve β-adrenergic-induced increases in heart rate and contractile force. In the present study, we uncover the primary mechanism underlying the heart's innate contractile reserve. We show that four protein kinase A (PKA)-phosphorylated residues in Rad, a calcium channel inhibitor, are crucial for controlling basal calcium current and essential for β-adrenergic augmentation of calcium influx in cardiomyocytes. Even with intact PKA signaling to other proteins modulating calcium handling, preventing adrenergic activation of calcium channels in Rad-phosphosite-mutant mice (4SA-Rad) has profound physiological effects: reduced heart rate with increased pauses, reduced basal contractility, near-complete attenuation of β-adrenergic contractile response and diminished …

An Optimized Bioassay For Screening Combined Anticoronaviral Compounds For Efficacy Against Feline Infectious Peritonitis Virus With Pharmacokinetic Analyses Of Gs-441524, Remdesivir, And Molnupiravir In Cats, Sarah Cook, Luke Wittenburg, Victoria C Yan, Jacob H Theil, Diego Castillo, Krystle L Reagan, Sonyia Williams, Cong-Dat Pham, Chun Li, Florian L Muller, Brian G Murphy

Faculty, Staff and Student Publications

Feline infectious peritonitis (FIP) is a fatal disease of cats that currently lacks licensed and affordable vaccines or antiviral therapeutics. The disease has a spectrum of clinical presentations including an effusive ("wet") form and non-effusive ("dry") form, both of which may be complicated by neurologic or ocular involvement. The feline coronavirus (FCoV) biotype, termed feline infectious peritonitis virus (FIPV), is the etiologic agent of FIP. The objective of this study was to determine and compare the in vitro antiviral efficacies of the viral protease inhibitors GC376 and nirmatrelvir and the nucleoside analogs remdesivir (RDV), GS-441524, molnupiravir (MPV; EIDD-2801), and β-D-N