Digital Commons Network^™

Ethical Analytics: A Framework For A Practically-Oriented Sub-Discipline Of Ai Ethics, Jonathan Boardman

Doctor of Data Science and Analytics Dissertations

Ethics can no longer be regarded as an add-on in data science and analytics. This dissertation argues for the necessity of formalizing a new, practically-oriented sub-discipline of AI Ethics by outlining needs, highlighting shortcomings in current approaches, and providing a framework for Ethical Analytics, a field concerned with the study of the ethical issues surrounding the development, deployment, and/or dissemination of ML/AI systems and data science research, as well as the development of tools and procedures to mitigate ethical harms. While data science and machine learning are primarily concerned with data from start to finish, ethical analytics is concerned primarily …

Differential Expression And Activities Of Cytochrome P450 3a In The Rat Brain Microsomes And Mitochondria, Nouf Alshammari, Devaraj Venkatapura Chandrashekar, Mamunur Rashid, Reza Mehvar

Pharmacy Faculty Articles and Research

Midazolam (MDZ), a benzodiazepine derivative, is metabolized to 1′- and 4-hydroxylated metabolites (1′-OH-MDZ and 4-OH-MDZ, respectively) by cytochrome P450 3A (CYP3A). The purpose of this study was to investigate the CYP3A-mediated hydroxylation of MDZ in the rat brain mitochondria (MT). Brain microsomes (MC) and MT fractions were prepared from rats (n = 8) using differential and density gradient centrifugations, and the purity of the fractions was evaluated using VDAC1 and calreticulin as markers of MT and MC, respectively. The formation rates of 1′-OH-MDZ and 4-OH-MDZ in the rat brain MC and MT samples were determined using an LC–MS/MS method …

The “Big Six”: Hidden Emerging Foodborne Bacterial Pathogens, Mona G. Alharbi, Rashad R. Al-Hindi, Ahmed Esmael, Ibrahim A. Alotibi, Sheren A. Azhari, Mazen S. Alseghayer, Addisu D. Teklemariam

Nebraska Center for Virology: Faculty Publications

Non-O157 Shiga toxin-producing Escherichia coli (STEC) are emerging serogroups that often result in diseases ranging from diarrhea to severe hemorrhagic colitis in humans. The most common non-O157 STEC are O26, O45, O103, O111, O121, and O145. These serogroups are known by the name “big six” because they cause severe illness and death in humans and the United States Department of Agriculture declared these serogroups as food contaminants. The lack of fast and efficient diagnostic methods exacerbates the public impact of the disease caused by these serogroups. Numerous outbreaks have been reported globally and most of these outbreaks were caused by …

Papyrus Of Ani Write-Up, Raja Ajaz

Publications and Research

A write-up and analysis of the Papyrus of Ani that was written for an undergraduate course.

Sex-Biased Differences In Infant Mortality And Life Expectancy At At Síi Túupentak, An Ancestral Ohlone Village In Central California (Ca. 540–145 Cal. Bp), Tammy Buonasera, Jelmer Eerkens, Brian Byrd, Laurel Engbring, Monica Arellano, Alan Leventhal, Glendon Parker

Human Biology Open Access Pre-Prints

Síi Túupentak (CA-SCA-565/H) is a late precontact ancestral Ohlone village and cemetery site in central California (ca. 540-145 cal. BP). Integration of proteomic, genomic, and osteological analyses provided highly confident biological sex estimates for remains of most individuals at this site (65 of 76) spanning all age groups—from perinatal infants to aged adults. The comprehensive nature of the data allowed us to generate sex-specific Kaplan-Meyer survivorship curves for this burial population of sedentary hunter-gatherers. As was common among societies pre-dating modern western medicine and antibiotics, infant mortality was high for both males and females. However, male infants (from birth to …

Kenyon Collegiate - November 7, 2022

Kenyon Collegiate

No abstract provided.

Exploring The Biomedical Applications Of Polyurethane-Based Foams, Films, And Hydrogels, Anand Utpal Vakil

Dissertations - ALL

Shape memory polymers (SMPs) are a class of smart materials that can be temporarily stored in a deformed shape and can actively recover their original shape upon exposure to an external stimulus, such as heat, magnetic field, moisture, pH, light, or electric field. The ability of SMPs to change shape when required can be used for a wide range of applications, especially in the case of minimally invasive biomedical applications. In this work, polyurethane-based SMPs were explored for their use in tissue engineering, drug delivery, and wound healing applications.

In the second chapter, low density porous foams with tunable degradability …

November 7, 2022

The Gavel Gazette

No abstract provided.

Manual On International Humanitarian Law For The Armed Forces Of The Russian Federation (2002)

International Law Studies

A translation of the Manual on International Humanitarian Law for the Armed Forces of the Russian Federation, 2002, by Aleksei Romanovski. This translation was originally published as Appendix 1 in Evan J. Wallach, The Law of War in the 21st Century (2017).

Curriculum Subcommittee, Minutes, November 3, 2022, Utah State University

Educational Policies Committee

• Approval of Minutes - October 6, 2022
• Program Proposals
• Semester Course Approval Reviews
• Other Business
• Adjourn: 3:00 pm

"Analytical," "Angry." And "(Too) Honest"?! Learners' Stereotypes About Teachers Of German., Lucian Rothe

Faculty and Staff Scholarship

This study investigated stereotypes about teachers of German that 67 novice learners of German at a U.S. university had reportedly encountered. Consequently, the investigation explored the perceived accuracy of clichés associated with native-speaker and non-native-speaker instructors. Students' stereotypical notions were sorted into categories using principles of grounded theory. Statistical analyses showed that respondents were able to list various stereotypes about instructors of German. Responses also reflected societal narratives concerning native-speaker and non-native-speaker teachers' strengths and shortcomings. Last, and of importance to the future of German Studies, participants considered more favorable stereotypes about teachers as more accurate and less-favorable clichés as …

American Horse Power During The Great War, Hanna K. Lipsey

USF Tampa Graduate Theses and Dissertations

This dissertation charts the significant, if understudied, history of American horses during the era of World War I, from roughly 1914 to 1919. Its chapters trace how the US Army acquired, used, cared for, and ultimately demobilized horses over the course of that conflict. Beginning with their acquisition, via either an Army Horse Breeding Program or a complicated buying process, horses faced a complex introduction into military service. Life for these animals did not get any easier once they reached the European front. Although the US military was beginning to replace horses with motor trucks and tractors, horses remained central …

High-Contrast Detection Of Somatostatin Receptor Subtype-2 For Fluorescence-Guided Surgery, Servando Hernandez Vargas, Solmaz Aghaamiri, Sukhen C Ghosh, Michael P Luciano, Luis C Borbon, Po Hien Ear, James R Howe, Jennifer M Bailey-Lundberg, Gregory D Simonek, Daniel M Halperin, Hop S Tran Cao, Naruhiko Ikoma, Martin J Schnermann, Ali Azhdarinia

Faculty, Staff and Student Publications

Dye design can influence the ability of fluorescently labeled imaging agents to generate tumor contrast and has become an area of significant interest in the field of fluorescence-guided surgery (FGS). Here, we show that the charge-balanced near-infrared fluorescent (NIRF) dye FNIR-Tag enhances the imaging properties of a fluorescently labeled somatostatin analogue.

Blank Spaces: An Exploration Of Memory And Nostalgia Through Mixed Media, Julianna V. Tillman

Honors College Theses

Blank Spaces explores the way childhood nostalgia manifests in the physical world through the creation of mixed media pieces. The experimentation with different mediums in my work, such as painting, ceramics, and animation, is emblematic of childhood creative play. These mixed media artworks showcase how memories recalled from the past can influence our interpretation of the present. The familial connection to family and culture, represented through manipulated old family photographs and imaginary renderings of stories, blends representational imagery with fantasy; my art examines the movement of those memories in the “blank spaces” of the mind. The thesis adds to the …

"You Must Defeat [The Tutorial] To Stand A Chance": Learning To Play Competitive Fighting Video Games, Aidan D. Rivas

All HCAS Student Capstones, Theses, and Dissertations

Modern competitive video games are complex systems that require players to learn techniques and develop strategies in response to computer- or human-controlled opponents. Building on the work of both game studies scholars and game designers, this thesis analyzes various learning spaces within and surrounding competitive video games, including in-game tutorials, arcades, and online communities. It focuses on “fighting games,” those competitive video games in which, typically, two players control characters to face off in single combat. Through analysis of the interfaces used, the audio-visual artifacts present within the tutorial sections of fighting games, and the paratextual materials produced by members …

Contribution Of The Orbitofrontal Cortex To Delayed Punishment Discounting, Anna E. Liley

Electronic Theses and Dissertations Archive

The ability to accumulate rewards while minimizing negative consequences is a valuable survival skill. Importantly, many psychiatric diseases such as substance use disorder (SUD; Bechara, 2005; Gowin et al., 2013), attention deficit hyperactivity (Magnus et al., 2021), anxiety (Hartley and Phelps, 2012), major depressive, bipolar, and schizophrenia disorders (Whitton et al., 2015) involve impaired decision-making that can lead to detrimental outcomes. One factor that causes maladaptive decision-making is insensitivity to negative consequences, especially those that occur later in time (Murphy et al., 2001; Bechara and Dolan, 2002; Field et al., 2019). These studies were among the first to investigate how …

Long Covid And The Neuroendocrinology Of Microbial Translocation Outside The Gi Tract: Some Treatment Strategies, Adonis Sfera, Carolina Osorio, Sabine Hazan, Zisis Kozlakidis, Jose Campo Maldonado, Carlos Manuel Zapata-Martín Del Campo, Jonathan J. Anton, Leah Rahman, Christina V. Andronescu, Garth L. Nicolson

School of Medicine Publications

Similar to previous pandemics, COVID-19 has been succeeded by well-documented postinfectious sequelae, including chronic fatigue, cough, shortness of breath, myalgia, and concentration difficulties, which may last 5 to 12 weeks or longer after the acute phase of illness. Both the psychological stress of SARS-CoV-2 infection and being diagnosed with COVID-19 can upregulate cortisol, a stress hormone that disrupts the efferocytosis effectors, macrophages, and natural killer cells, leading to the excessive accumulation of senescent cells and disruption of biological barriers. This has been well-established in cancer patients who often experience unrelenting fatigue as well as gut and blood– brain barrier dysfunction …

Robot-Assisted Radical Prostatectomy: What To Expect For Your Surgery?, Julia Lunavictoria

Theses

Prostate cancer is one of the most common types of cancer, affecting over 191,930 men, with an estimated 34,500 deaths for 2022 in the United States (NIH, 2022). As men age, the risk for prostate cancer increases; about 34% of all men diagnosed with prostate cancer are above the age of 50, and a staggering 70% are over the age of 80. Robot-assisted radical prostatectomy (RARP) is a minimally invasive surgical procedure used to treat clinically localized prostate cancer. In some cases, hydrodissection is used in nerve-sparing surgeries, protecting the neurovascular bundle and ensuring a higher chance of potency for …

Pi3k Isoform-Specific Regulation Of Leader And Follower Cell Function For Collective Migration And Proliferation In Response To Injury, Morgan D Basta, A. Menko, Janice L Walker

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

To ensure proper wound healing it is important to elucidate the signaling cues that coordinate leader and follower cell behavior to promote collective migration and proliferation for wound healing in response to injury. Using an ex vivo post-cataract surgery wound healing model we investigated the role of class I phosphatidylinositol-3-kinase (PI3K) isoforms in this process. Our findings revealed a specific role for p110α signaling independent of Akt for promoting the collective migration and proliferation of the epithelium for wound closure. In addition, we found an important role for p110α signaling in orchestrating proper polarized cytoskeletal organization within both leader and …

Defining Understudied Mechanisms Of Potassium Ion Flux In The Insect Nervous System, Rui Chen

LSU Doctoral Dissertations

To identify novel insecticide target sites that can address the evolution of insecticide resistance, our group has tested the insecticidal potential of two potassium flux pathways: potassium-chloride (K+/Cl−) cotransporter (KCC) and inward rectifier potassium (Kir) channels. GABAergic signaling is the cornerstone of fast synaptic inhibition for neural signaling in arthropods; thus, the γ-aminobutyric acid (GABA)-receptor-chloride-channel (GRCC) complex has been a longstanding target for insecticides. Despite the importance to neuronal homeostasis, the upstream mechanisms enabling GRCC function are poorly defined. The data presented in this dissertation provide strong support that KCC is an essential ion transport system for proper neural function …

Languages Of Reform: Populist Revolution Or Middle-Class Progressivism?, Timothy Vest Klein

LSU Doctoral Dissertations

Populists and Progressives around the turn of the 20^th century had similar reform goals and many of the same foes. Both wanted to expand the power of the federal government to counter corporate monopolies which were dominating the nation’s economy and political system. In the early 1900s, Progressives enacted numerous reforms that were championed by Populists, including regulating railroads and other large corporations, breaking-up monopolies, implementing a graduated income tax, among other reforms. With so much agreement on policy, why did Populists and Progressives actively work against one another in the 1890s?

Part of their antagonism came from their …

The Dobbs Effect: Abortion Rights In The Rear-View Mirror And The Civil Rights Crisis That Lies Ahead, Terri Day, Danielle Weatherby

William & Mary Law Review Online

On June 24, 2022, seven weeks after the first-ever leak of a draft opinion, the United States Supreme Court circulated its decision in Dobbs v. Jackson Women’s Health Organization, defying stare decisis, overruling fifty years of precedent, and shattering the hopes of millions of Americans, who wished the leaked opinion was a fiction that would never come to be.

As the leaked draft forewarned, Roe v. Wadeis no longer the law of the land. No longer is a woman’s right to terminate a pregnancy—to exercise bodily autonomy and be free to control the trajectory of her life—protected as a fundamental …

Circadian Misalignment And Childhood Obesity: An Unexplored Target For Intervention And Treatment, Mason Pilling

Student Works

Childhood obesity is a pandemic affecting almost 40 million individuals aged 5-18 globally. Many current interventions are relatively successful at treating childhood obesity, yet the rate of childhood obesity continues to increase from year to year, and current intervention methods are struggling to keep up. Mounting evidence suggests that sleep may be a crucial mechanism for understanding and treating obesity, yet sleep still remains a relatively unexplored target for intervention. Circadian misalignment, a measure of the difference between the body’s preferred sleep timing and actual bed and wake times, has been almost completely ignored in the literature, despite preliminary findings …

The Applied Use Of Zein Nanoparticles In Agriculture, Colin Bonser

LSU Doctoral Dissertations

Nanotechnology is a multifaceted and a promising strategy in agricultural pest management for the development of insecticides or insecticide carriers. Research has shown that nanoparticles increase stability and efficacy of entrapped chemical pesticides to prevent active ingredient degradation while improving chemical stability and solubility. The following work evaluated nanoparticles synthesized from biopolymers, materials that originate from renewable sources also have an increased biodegradability.
Work was conducted under laboratory, greenhouse, and field conditions to test the biopoloymers as possible insecticide and insecticide carriers. The primary biopolymer evaluated in the following studies was zein, although lignin and chitosan were also evaluated. Overall, …

Full Issue

Studia Antiqua

No abstract provided.

Propagation Vs Intrusion: Islamic Influences In Medieval Georgia, Jake Hubbert

Studia Antiqua

No abstract provided.

Akhenaten's Religious Reforms, Chris Cox

Studia Antiqua

No abstract provided.

Nabataeans, Dogs And Tuna: Chamber Tomb Faunal Remains And Their Association With Rome And Egypt, Samantha Bostwick

Studia Antiqua

No abstract provided.

Unexpected Opportunities For Manatee (Trichechus Manatus Latirostris) Education And Citizen Science, Yvanna M. Strait, Amy Hirons

Marine & Environmental Sciences Faculty Articles

The Florida manatee (Trichechus manatus latirostris) mainly resides within the state's coastal waters, but sharing this habitat with thousands of watercrafts, either registered, unregistered, or visiting, has proven challenging for its survival. The future of manatee research among scientists and citizen scientists has strong potential. By taking advantage of venues of opportunity such as boat shows, not only is local population data gathered, but a stronger positive relationship with the public is forged. When people feel they have a stake in the conservation of a species or habitat, they will likely become and remain engaged.

The Stockholm Paradigm: Lessons For The Emerging Infectious Disease Crisis, Daniel R. Brooks, Walter A. Boeger, Eric P. Hoberg

MANTER: Journal of Parasite Biodiversity

The emerging infectious disease (EID) crisis represents an immediate existential threat to modern humanity. Current policies aimed at coping with the EID crisis are ineffective and unsustainably expensive. They have failed because they are based on a scientific paradigm that produced the parasite paradox. The Stockholm paradigm (SP) resolves the paradox by integrating four elements of evolutionary biology: ecological fitting, sloppy fitness space, coevolution, and responses to environmental perturbations. It explains why and how the EID crisis occurs and is expanding and what happens after an EID emerges that sets the stage for future EIDs. The SP provides a number …