Digital Commons Network^™

Conserving And Sharing Freshwater In The West, Kelsea Harris-Capuano

Graduate Student Theses, Dissertations, & Professional Papers

There are infinite stories to be told about water in the West. As an essential and finite resource, countries, states, tribal nations and neighbors must figure out how to manage this shared resource, whether for ecosystem sustainability, agricultural, household, or recreational use.

The Flathead Lake Biological Station in Polson, MT is one of the oldest active biological research stations in the United States. One of its former faculty, Dr. Mark Lorang, has been working on Flathead Lake’s erosion problem for over 30 years. As a result of seasonal lake level fluctuations controlled by the dam, erosion over the years has …

Rancher Perspectives On Livelihood Diversification Options In Montana's Blackfoot River Watershed, Sara N. Schmidt

Graduate Student Theses, Dissertations, & Professional Papers

The Blackfoot River watershed in Western Montana, like many rural landscapes across the Intermountain West, has faced a suite of economic, demographic, and social change over the last 40 years. Cattle ranching specifically, a principal land use in the Blackfoot watershed, has faced increasing socioeconomic challenges due to global competition, falling cattle prices, amenity migration, and climate change. Ranch livelihood diversification presents an opportunity to bolster the profitability of ranches in the watershed, while also supporting the well-being of rural communities and conserving the intact, ecologically-significant rangelands upon which ranching depends. The Blackfoot Challenge (BC) is a nonprofit community-based conservation …

The Mountain Home: Spatial And Optimal Foraging Assessments Of Hunter- Gatherer Mountain Landscape Use In The Beartooth Mountains, Montana, Scott William Dersam

Graduate Student Theses, Dissertations, & Professional Papers

Patterns of cultural mountain adaptations are recorded throughout the Western Cordillera of North America. They demonstrate prolonged and complex uses of these ecosystems over the Holocene. What behaviors or circumstances in the Early Holocene transitioned mountains from inhospitable to reliable territory? This research addresses this question in the Beartooth Mountains of the Greater Yellowstone Ecosystem (GYE).

Foraging behaviors dictate hunter-gatherer mobility and habitation patterning. These behaviors are reflected in the spatial arrangement of archaeological activity areas and lithic tools in mountainous ecosystems. Energy-demanding ecosystems, require foraging behaviors and habitation strategies that conserve energy. I assert that to understand the emergence …

Body Temperature And Reproductive Effort In A Long-Lived Tropical Songbird, Holly R. Jackson

Graduate Student Theses, Dissertations, & Professional Papers

Heat production relative to dissipation rates have constrained reproductive effort and reduced fitness in short-lived, temperate birds. To determine whether heat constrains reproductive effort in long-lived taxa with low reproductive effort, we experimentally clipped plumage from tropical Gray-throated babblers (Stachyris nigriceps) to increase heat dissipation rates. Contrary to findings in short-lived species, we found no strong evidence of heat dissipation constraints on reproductive effort in our mid-elevation study. Clipped adults did not increase feeding rates compared to controls, but clipped females did spend more time incubating and brooding eggs and young. Increased time in the nest may reduce increased heat …

What’S Your Snapscore? Correlations To Personality, Narcissism, And Anxiety, Samantha Chambers, Scott P. King

Modern Psychological Studies

Snapchat is a popular social media network, but considerably less researched than other more established platforms. The purpose of this study was to examine how the amount of Snapchat use is correlated to personality, narcissism, and anxiety. We hypothesized there would be positive correlations between Snapchat usage and narcissism, extroversion, and anxiety. Using data from a convenience sample of participants recruited from Amazon Mechanical Turk, Pearson’s correlations and t-test analysis provided insight on these connections. There were significant positive correlations between Snapchat usage and narcissism, anxiety, and extraversion, but t-test analyses revealed that the users with low Snapscores had higher …

Cafos And Surface Water Quality: Evidence From Wisconsin, Zach Raff, Andrew G. Meyer

Economics Faculty Research and Publications

Concentrated Animal Feeding Operations (CAFOs) – animal feeding operations with over 1,000 animal units in confined spaces – have proliferated over the past 30 years in the United States. CAFOs provide operational cost savings, but higher animal concentrations in confined spaces can generate external costs, e.g., non-point source water pollution. In this study, we improve on previous research designs to estimate the relationship between the growth in CAFOs and surface water quality using longitudinal data on a large spatial scale. We use a panel dataset from 1995-2017 that links CAFO intensity with nearby surface water quality readings in Wisconsin to …

Recovery Of A Cylindrical Body Into An Outer Tube, Michael Berry, Daniel Deleon, Connor Rouillier, Jaxon Royal

Mechanical Engineering Capstone Design Projects

The use of unmanned vehicles by the U.S. Military is an evolving method of weapon deployment and data acquisition. As the use of these devices increase as the technology surrounding them evolves, the method of retrieval of these unmanned vehicles needs to advance as well. Consequently, The Naval Undersea Warfare Center (NUWC) is interested in devising a method of recovering Unmanned Underwater Vehicles (UUVs) and has asked Team 3 from the University of Rhode Island’s College of Engineering’s Capstone teams to design and build a device or method of retrieval. While methods of retrieval of these devices already exist, they …

Contributions Of Intrinsic Timescales Of Neural Dynamics To Population-Level Coding Of Task-Relevant Signals In Medial Prefrontal Cortex, Jisu Lee

Dartmouth College Master’s Theses

The brain integrates information from the external world with multiple timescales of neural dynamics. Among the various timescales, intrinsic timescales and timescales for integration of task-relevant signals (e.g. reward-memory timescales) have widely been studied but mainly independently. Here, we explore the distinct and coordinated contributions of different timescales in population-level encoding, using a recent method to simultaneously estimate various timescales of neural dynamics using electrophysiological recordings in the medial prefrontal cortex (mPFC) and the anterior lateral motor cortex (ALC). To identify the characteristics of each timescale, we evaluated the ability of neurons with different timescales in decoding task-relevant signals. The …

Law And Recordkeeping: A Tale Of Four African Countries, Darra Hofman, Shadrack Katuu

Faculty Research, Scholarly, and Creative Activity

No abstract provided.

Review Of Evidence For Environmental Causes Of Uveal Coloboma, Evan B Selzer, Delphine Blain, Robert B Hufnagel, Philip J Lupo, Laura E Mitchell, Brian P Brooks

Faculty, Staff and Student Publications

Uveal coloboma is a condition defined by missing ocular tissues and is a significant cause of childhood blindness. It occurs from a failure of the optic fissure to close during embryonic development and may lead to missing parts of the iris, ciliary body, retina, choroid, and optic nerve. Because there is no treatment for coloboma, efforts have focused on prevention. While several genetic causes of coloboma have been identified, little definitive research exists regarding the environmental causes of this condition. We review the current literature on environmental factors associated with coloboma in an effort to guide future research and preventative …

Wade Barber Roddey Papers - Accession 1700, Wade Barber Roddey, Roddey Family, Hyatt Family, Killian Family, Mcfadden Family, Lyle Family, Knox Family, Culp Family, White Family, Gettys Family, Cherry Family, Edwards Family, Ferguson Family

Manuscript Collection

This collection consists of genealogical research conducted by Wade Barber Roddey (1878-1970). Wade Roddey was a local businessman and served as a Corporal in Company G 1st Regiment South Carolina Infantry during the Spanish American War. His research spans from the early 1800s up through 1970 and focuses on families from York and Chester Counties. Some of the more prominent family names that are covered in his research materials include the Cherry, Culp, Edwards, Ferguson, Gettys, Hyatt, Killian, Knox, Lyle, McFadden, Roddey, and White families. The collection also includes historical materials concerning local churches such as the Catholic Presbyterian Church …

Ecology Of The Diamondback Terrapin (Malaclemys Terrapin Pileata) In Alabama: Applications Of New Technologies, Forrest William Collins

All ETDs from UAB

The Diamondback Terrapin, Malaclemys terrapin pileata, inhabits saltmarshes in the Northern Gulf of Mexico including along the coast of Alabama. Due to a variety of factors, this species has declined drastically in Alabama, and it is currently designated as a “species of highest conservation concern”. Understanding the ecology of this species is a prerequisite to the recovery of this population. The current thesis addresses the reproductive and foraging ecology of the Diamondback Terrapin in Alabama. This thesis combines the use of classic ecological methodologies with modern technologies. Between April 2019 to July 2022, wild nesting females were caught at a …

The Ethos Of Donald Trump: Trump's Lack Of Presidential Decorum From 2016 Forward And Its Impact On American Politics, Nora M. Krall

All ETDs from UAB

In American politics, the concept of presidential decorum is upheld through the complexity of political and presidential rhetoric. When Donald Trump became president, he sought to break what standard decorum was in order to justify his desires as president. This breaking of decorum is complex in nature and is paired with mediatization, demagoguery, populism and collectivism, all of which are rhetorical strategies that challenge the norms within American democracy and in turn, have created a shift in what is considered presidential. Donald Trump seeks to utilize his personal ethos alongside these rhetorical methods to infiltrate multiple subsets of society, thus …

Klf2 Regulation Of Glycocalyx Expression, Barrier Function, And Thromboinflammation In Human Lung Microvascular Endothelial Cells, Cambria O'Grady

All ETDs from UAB

KLF2 is an important transcription factor for maintaining vascular homeostasis. Its expression in endothelial cells is triggered by shear stress. The endothelial glycocalyx also plays a role in regulating vascular function, and prior work has shown that glycocalyx expression is affected by shear stress as well. However, the direct link between KLF2 and mechanisms that regulate glycocalyx synthesis has not been established. In the present study, we used human lung microvascular endothelial cells (HLMVECs) to observe changes in glycocalyx expression, barrier function, and thromboinflammation caused by KLF2 overexpression. Lentiviral transduction was the method used for KLF2 overexpression, resulting in a …

Study Of Microrna-23a Cluster In Bone Formation, Revati Suryawanshi

All ETDs from UAB

The differentiation of mesenchymal stem cells to pre-osteoblasts, lies upon various transcription factors and physiological signaling, but is also governed by the micro-RNA-23a cluster. The miR-23a cluster has miR-23a, miR-27a and miR-24-2 transcribed from a single promoter as a sole RNA primary transcript. Its effects have been observed in embryonic stem cells, mesenchymal stem cells (MSCs), and in cancer (1-2). It regulates the lineage commitment of MSCs. (3). With respect to bone formation, miR-23a cluster is involved MSCs commitment to and osteoblast maturation (4). Here, through in vivo and in vitro experiments, we report that knock down of microRNA-23a cluster …

‘Big’ And ‘Little’ Quo Vadis? In The United States, 1913–1916: Using Gis To Map Rival Modes Of Feature Cinema During The Transitional Era, Jeffrey Klenotic

Faculty Publications

This article emanates from a geospatial database of over 600 premieres of the Cines company’s Quo Vadis? (1913), an eight-reel film distributed by George Kleine, and nearly 250 premieres of the Quo Vadis Film Company’s Quo Vadis? (1913), a three-reel film of ambiguous origins distributed by Paul De Outo. By mapping local premieres of both films across the United States from 1913 through 1916, the data show with spatiotemporal precision the spread of Quo Vadis? as one of cinema’s early blockbuster titles. Yet within this national phenomenon, the two films’ footprints reveal differing cultural geographies served by competing efforts to …

Alterations In Synaptic Structure And Tau Phosphorylation In Alheimer's Disease, Courtney K. Walker

All ETDs from UAB

Alzheimer’s disease (AD) is the most common cause of dementia in individuals over the age of 65. Of the two hallmark pathologies of AD, tau neurofibrillary tangles (NFTs) correlate more strongly with cognitive decline than do Aβ plaques. NFTs form in the entorhinal cortex (EC) and appear in anatomically connected regions over time as disease progresses. This tau spreading may occur via synaptic connections. Most excitatory synapses occur on dendritic spines, which house the postsynaptic machinery. Spines are actin-rich, plastic structures that change their size and shape in response to synaptic activity in a process that is dependent on actin …

Renal Lactate Dehydrogenase A: Underlying Mechanisms And Inflammatory Roles In Acute Kidney Injury, Gunars Osis

All ETDs from UAB

Kidneys are physiologically vital organs responsible for blood homeostasis preservation through fluid balance maintenance, blood pressure regulation, hormone production, and toxic compound removal. Acute kidney injury (AKI) is a global condition affecting more than 13 million people yearly, and is characterized by a rapid decline in renal filtration capacity, consequent rise in serum creatinine and nitrogenous waste levels, and is associated with an elevated risk of morbidity in the form of progressive chronic kidney disease, kidney failure, and mortality. AKI-induced renal epithelial cell death forces surviving tubular cells to undergo de-differentiation, rapid proliferation to replace lost cells, and re-differentiation to …

Study Of The Effects Of Contusion Spinal Cord Injury And Optogenetic Stimulation On Lower Urinary Tract Function, Salvador A. Lopez

All ETDs from UAB

Lower urinary tract (LUT) dysfunction is a detrimental ailment that negatively affects a person’s independence, health, and overall quality of life. More specifically, LUT dysfunction as a result of spinal cord injury (SCI) is seen in more than 17,000 cases per year and of those cases, <20% are discharged from care with normal micturition1. Initially, after SCI, there is an acute period of spinal shock when the urinary bladder is flaccid and underactive, while the external urethral sphincter (EUS) that constricts the bladder outlet quickly becomes tonically active. In days to weeks after injury, spinallymediated, reflex bladder contractions re-emerge2-4. Numerous studies have examined aspects of LUT function using various models of SCI, primarily utilizing complete transection injuries. This set of studies first examined the effect of moderate to severe midthoracic contusion SCI on LUT function by examining cystometrogram (CMG) and EUS recordings, bladder/spinal cord morphology, sensory innervation of bladder tissue, and spinal neuronal activation in female mice. This model of SCI produced significant changes in normal bladder function as well as altered bladder morphology, including a robust loss of bladder afferent nerve fibers necessary for micturition. Inhibition of histone deacetylase 6 (HDAC6) has been shown to prevent the loss of sensory nerve fibers in mouse hind paw tissue5, thus HDAC6 inhibition was examined as a possible strategy to prevent the observed loss of sensory nerve fibers in bladder tissue post-SCI. iv Mice were treated using intraperitoneal injections of inhibiting compounds ACY-1083 (10 mg/kg) or Tubacin (5 mg/kg). Treatment resulted in significant improvements in CMG measures and sensory innervation of the bladder wall. Finally, optogenetic stimulation was examined using an adenoassociated virus containing cre-recombinase for cre-dependent expression of channelrhodopsin (ChR2) in both spinal intact and SCI mice. The ability to spare afferent axons in bladder tissue post-SCI through HDAC6 inhibition allowed ChR2 expression in sensory nerve fibers. Direct photostimulation of the bladder using various parameters of duration (1, 2, 5, 10 sec continuous stimulation) and power (0.1mW/mm2, 0.95mW/mm2, 6.50mW/mm2) resulted in the ability to control bladder contractions in both spinal intact (SI) and SCI animals, allowing for on-demand voiding post-injury.

Hedgehog Signaling Rewires M2 Macrophage And Regulatory T Cell Metabolism Within The Tumor Microenvironment Of Breast Cancer, Dominique C. Hinshaw

All ETDs from UAB

Current treatments for breast cancer offer little relief to patients with metastatic disease. A contributory factor to tumor growth and metastasis is aberrant up-regulation of developmental signaling pathways such as the Hedgehog (Hh) signaling pathway. This pathway is aberrantly activated in breast cancer and contributes to tumor progression and metastasis. The success of these events is highly influenced by the surrounding immune microenvironment. Macrophages exist along a spectrum of M1 (tumor-eradicating) to M2 (tumor-promoting), while regulatory T cells (Tregs) are an immunosuppressive cell type. The predominant functions of M2 macrophages and Tregs include dampening the immune response and promoting wound …

Fire Starters: Using A Train-The- Trainer Model And Team Consultations To Support A First-Year Experience Business Competition, Benjamin Peck, Wendy G. Pothier

Faculty Publications

No abstract provided.

Pkd-1 Signaling Inthe Regulation Of Cancer Stem Cell-Like Features And Cancer Cell Interactions With Endothelial Cells In Breast Cancer And Pancreatic Neuroendocrine Tumor, Yichen Hailey Guo

All ETDs from UAB

Cancer stem cells (CSCs) are a subpopulation cancer cells that play critical roles in tumor progression, recurrence, metastasis, and drug resistance. CSCs are characterized by self-renewal and plasticity. Protein kinase D-1 (PKD-1) signaling regulates CSC/stemness features in both breast cancers and pancreatic neuroendocrine tumors. In PNETs, PKD-1 signaling regulates not only stemness properties of cancer, but also epithelial-mesenchymal transition (EMT). PNETs are typically well vascularized and heterogeneous. Everolimus (an mTOR inhibitor and the 2nd generation derivative of rapamycin) has been approved as a targeted chemotherapy for PNET patients. Unfortunately, nearly all patients will progress on treatment due to drug resistance …

The Role Of Protein Translation And Degradation In Aging And Alzheimer Disease Pathogenesis, Harper S. Kim

All ETDs from UAB

Protein translation (PT) is an essential cellular process playing crucial roles in growth and development. PT precipitously declines with age in multiple animal species, including humans. It has been implicitly assumed that elevated PT at young ages is beneficial to health while PT ends up dropping as a passive byproduct of aging. However, whether this holds true and how dynamic fluctuations in PT over time impact aging remain unknown. In Drosophila, we show that a transient PT spike in early-adulthood drives aging by triggering dysfunction in protein homeostasis (proteostasis) at old ages. We propose the early-adulthood spike in PT to …

Determining The Impact Of Immune Dysregulation On Cd4 T Cell Responses To Hiv-1 And Sars-Cov-2, Jacob K. Files

All ETDs from UAB

CD4+ T cells, often referred to as helper T cells, play a crucial role in the formation of antiviral immune responses following infection and vaccination. However, this can be disrupted by various forms of immune dysregulation. Many groups have described how HIV-1 adaptation and immune escape can lead to dysregulated HIV-specific immune responses. Our lab has previously shown that predicted HLA-II associated HIV-1 adaptation leads to dysregulated, poorly immunogenic CD4+ T cell responses in HIV-1 infection. Here, we focus on the impact of this HLA-II associated viral adaptation in the setting of HIV-1 vaccination. We show that HLA-II associated, vaccine-matched …

Driving Anger And Aggression In Persons With And Without Adhd, Maria T. Lechtreck

All ETDs from UAB

Driving a motor vehicle is both a privilege and one of the primary activities of daily living for most persons in the U.S. and many persons abroad; however, motor vehicle collisions (MVCs) bring great costs both to individuals and society. Driver behavior is the critical factor in an estimated 94% of MVCs and aggressive driving is the cause of two-thirds of U.S. traffic fatalities. Certain populations are at an increased risk for MVCs including persons who are young (ages 15-24), persons who have developmental disabilities such as Attention-Deficit/Hyperactivity Disorder (ADHD), and persons who have a high propensity for driving-related anger. …

Biomanufacturing Of Micro-Myocardial Tissue Through Suspension Differentiation With Improved Yields, Purity, And Quality, Asher M. Kahn-Krell

All ETDs from UAB

Despite major advances in revascularization and drug therapy for post-myocardial infarction (MI) heart failure (HF), heart transplantation remains the only curative therapy to prevent progressive and debilitating disease. Researchers have long sought a replenishable and expandable source of cardiomyocytes (CMs), the primary functional cell in the heart muscle, for a broad array of applications related to the treatment of HF ranging from direct implantation to high throughput drug testing. The lack of cell cycle activity and cell division in adult CMs prevented the development of an expandable primary cell line. However, with the discovery of high efficiency stem cell differentiation …

Temperature-Dependent Sex Determination (Tsd): Implications For The Biology And Conservation Of The Kemp's Ridley Sea Turtle (Lepidochelys Kempii), Katherine Presz

All ETDs from UAB

The Kemp’s ridley sea turtle (Lepidochelys kempii) has temperature-dependent sex determination (TSD) where the incubation temperature of the egg determines the sex of the hatchling. This has significant implications for the ecology, evolution, and conservation of this species because it can affect sex ratios. The studies presented in this thesis address hatchling sex ratios produced in Kemp’s ridley conservation programs using both natural as well as manipulated incubation regimes. First, a histology-based study was utilized to investigate sex ratios produced at the Padre Island National Seashore from 2002-2019. The results indicate that a female bias has been produced each year …

Early Life Stress And Barrier Dysfunction Of The Blood-Brain Barrier, Margaret Ellen Lloyd

All ETDs from UAB

Early Life Stress (ELS) refers to any process or event of chronic and/or sever stress that occurs early in an individual’s development; this can be spurred by environmental or behavioral cues and helps predict inflammation later1 in life. ELS is associated with increased risk of cardiovascular disease (CVD) and other chronic conditions like depression. However, many of the physiological processes that lead to increased risk of chronic illness later in life have yet to be established or examined. The ELS mouse model is used to examine the unknown mechanistic links between childhood stress and risk for chronic disease in adulthood. …

An Evaluation Of The In Vitro Antibacterial, Biocompatibility, And Mineralization Properties Of Six Calcium Silicate-Based Pulp Capping Materials, Taimy Cruz Hondares

All ETDs from UAB

Purpose: The purpose of this study was to evaluate the antibacterial activity, biocompatibility, and mineralization-inducing potential of calcium silicate-based pulp capping materials. Methods: Six contemporary calcium silicate-based pulp capping materials were compared in this study, including ProRoot MTA, MTA Angelus, Biodentine, EndoSequence, NeoMTA 2 and NeoPutty. The antibacterial effects of these materials against Streptococcus mutans UA159 and Enterococcus faecalis ATCC 29212 were determined by the agar-diffusion assay and the direct culture test. The biocompatibility and mineralization-inducing potential of these materials in preodontoblastic 17IIA11 cells were compared by the MTT assay and by evaluating alkaline phosphatase activity and calcium deposits, respectively. …

Dear Former Phenom, Meredith Beretta

All ETDs from UAB

Dear Former Phenom is a collection of essays and poems covering my life as a female athlete in America, beginning when I was a small child and continuing to my retirement after my senior year as a collegiate student-athlete. As it stands, the collection is incomplete. This current version contains the core memories and the foundation of my discussion. This collection tells the story of my failure to reach my full potential as an athlete. It is the story of me constantly achieving higher and higher achievements, awards, accolades, and praise until I didn’t anymore. Until there was no one …