Digital Commons Network^™

Meta-Analysis Of Major Histocompatibility Complex (Mhc) Class Iia Reveals Polymorphism And Positive Selection In Many Vertebrate Species, Donald Dearborn, Sophie Warren, Frank Hailer

All Faculty Scholarship

Pathogen-mediated selection and sexual selection are important drivers of evolution. Both processes are known to target genes of the major histocompatibility complex (MHC), a gene family encoding cell-surface proteins that display pathogen peptides to the immune system. The MHC is also a model for understanding processes such as gene duplication and trans-species allele sharing. The class II MHC protein is a heterodimer whose peptide-binding groove is encoded by an MHC-IIA gene and an MHC-IIB gene. However, our literature review found that class II MHC papers on infectious disease or sexual selection included IIA data only 18% and 9% of the …

When Patients Are Their Own Doctors: Roe V. Wade In An Era Of Self-Managed Care, Yvonne F. Lindgren

Faculty Works

The Supreme Court in Roe v. Wade framed the abortion right as a right to make the abortion decision in consultation with a “responsible physician.” Under this framing, doctors were cast in the role of medical “gatekeepers” to mediate patient access to abortion. In the ensuing years, the doctor-patient relationship has become the site of restrictive abortion regulations in many states. This Article argues that Roe’s framing suffers from a foundational flaw: While the gatekeeper framing may have been appropriate in the Roe era when abortion was surgical and non-clinical abortions were potentially lethal, today, medication abortion—a two-drug non-surgical regimen …

How Experts Have Dominated The Neuroscience Narrative In Criminal Cases For Twelve Decades: A Warning For The Future, Deborah W. Denno

Faculty Scholarship

Phineas Gage, the man who survived impalement by a rod through his head in 1848, is considered “one of the great medical curiosities of all time.” While expert accounts of Gage's post-accident personality changes are often wildly damning and distorted, recent research shows that Gage mostly thrived, despite his trauma. Studying past cases such as Gage’s helps us imagine—and prepare for—a future of law and neuroscience in which scientific debates over the brain’s functions remain fiery, and experts divisively control how we characterize brain-injured defendants.

This Article examines how experts have long dominated the neuroscience narrative in U.S. criminal cases, …

Does Pesticide Regulation Impact The Export Competitiveness Of Major Global Cocoa Producers?, Olaide Akin-Olagunju, Abiodun Falusi, Sulaiman Yusuf, Victor Okoruwa

Journal of African Trade

Abstract Several methods are used to evaluate competitiveness, but the non-inclusion of quality measures, despite their importance in international product markets, gives less credence to such assessments. This study evaluates export competitiveness in the cocoa sector from the context of pesticide regulations. Such regulations are now increasingly common, due to their perceived benefits for humans, animals, and the environment. The results of our study show that cocoa-exporting countries stand to derive more earnings if standards are harmonized at the Codex level. Adherence to international standards, as reflected in large standard-scaled trade values, enhances competitiveness: yet compliance capacity must be matched …

The Most Suitable Types Of Obturator For Stomatognathic System Rehabilitation After Maxillofacial Surgery: A Systematic Review, Riezky Rhamdani, Irfan Dammar

Journal of Dentomaxillofacial Science

No abstract provided.

The Effect Of Administration Of Siamese Catfish (Pangasius Hypophthalmus) Extract On Fibroblast Cells After Tooth Extraction In Wistar Rats, Veny Larasati, Trisnawaty, Angelina N. Ricardo

Journal of Dentomaxillofacial Science

No abstract provided.

Mthfr C677t Mutation Affects Adipogenic Differentiation Abilities Of Human Bone Marrow-Derived Mesenchymal Stem Cells, Rengi̇m Vural, Di̇cle Çeli̇k, Ersi̇n Berkay Peker, Eki̇n Köni̇, Ayşe Aydanur Kulaç, Zeynep Tokcaer Keski̇n

Turkish Journal of Biology

The effects of 5,10-Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism on human bone marrow-derived mesenchymal stem cells (hBM-MSCs) viability, morphology, physiology and differentiation capacity were investigated in this study. For this purpose, primary hBM-MSCs with wild type (WT, C/C), heterozygote (HTZ, C/T) and homozygote (HMZ, T/T) for the MTHFR gene were obtained with ethical committee permission and donor informed. Mutations were detected using RFLP and Sanger sequencing methods from genomic DNA isolated from cells, colonization properties were investigated by CFU-F test and proliferative differences were investigated by MTT test. Adipogenic, osteogenic, and chondrogenic differentiation were induced to study changes in their differentiation …

Comparison Of The Different Isoforms Of Vitamin E Against Amyloid Beta-Induced Neurodegeneration, Alp Yi̇ği̇t Özdemi̇r, Esi̇n Çeti̇n, Mehmet Ali̇ Onur

Turkish Journal of Biology

Neurodegeneration is the progressive loss of structure or function of neurons. Amyloid beta oligomers and aggregates have been linked to neurodegeneration. While previous studies have suggested that dietary α-tocopherol intake can prevent amyloid beta aggregation and protect the brain against neurotoxicity, other research, however, indicated that tocotrienol forms might be used as an alternate agent against this kind of degeneration. In the presented research, we compared the in vitro protective effects of α-tocopherol and α-tocotrienol. In this context, we formed an in vitro neurodegeneration model with primary isolated neurons and measured α-tocopherol's and α-tocotrienol's protective effects. As a result, α-tocopherol …

The Investigation Of Diverse Physiological And Therapeutic Impact Of Cellular-Based Products Derived From Human Cumulus Cells, Derya Burukçu, Sema Yilmaz, Oya Alagöz, Cumhur Kaan Yaltirik, Neci̇p Erkut Attar, Fi̇kretti̇n Şahi̇n, Esra Aydemi̇r Çoban

Turkish Journal of Biology

Particular somatic cells, namely cumulus cells (CCs) that support the oocyte maturation, fertility, and viability by providing the nutrients and energy to the oocyte envelop the mammalian oocyte. In this study, discarded human cumulus tissues were used to reveal the value of hyaluronic acid-rich CCs on several cellular events, including differentiation. Conditioned media, recovered from the primary culture of CCs, were introduced to the human nucleus pulposus cells (hNPCs) which were functionally distorted because of the loss of chondrogenecity. Enlightening the impact of cumulus conditioned media (CCM) on wound healing and angiogenesis was also investigated. In line with these goals, …

Protecting Our At-Risk Communities From The Ground(Water) Up: Cafos, The Clean Water Act, And A Framework For Offering Clarity To An Imprecise Maui Test, Shawn D. Ren

Emory Law Journal

For rural communities across the country, the problems associated with concentrated animal feeding operations (CAFOs) are nothing new. These industrial-sized operations emit a tremendous amount of waste, polluting the surrounding air, land, and water. In many regions, minority, indigent, and uneducated groups disproportionately bear the ill-effects of these inhumane operations. Under the Clean Water Act, CAFOs are explicitly included in the definition of a point source and are thus subject to the National Pollutant Discharge Elimination System (NPDES) permitting requirements, which regulates the discharge of pollutants. However, many operations do not fit within this regulatory scheme as they do not …

When A Statute Comes With A User Manual: Reconciling Textualism And Uniform Acts, Gregory A. Elinson, Robert H. Sitkoff

Emory Law Journal

This Article develops an interpretive theory for statutes that originate as Uniform Acts promulgated by the Uniform Law Commission. Although overlooked in the literature on statutory interpretation, state-enacted Uniform Acts are ubiquitous. They shape our life cycles—governing marriage, parentage, divorce, and death—and structure trillions of dollars in daily commercial transactions.

Largely focusing on textualism, today’s dominant form of statutory interpretation, we analyze the interpretive consequences of two unusual features of state-enacted Uniform Acts. First, the text of every Uniform Act directs courts to interpret it to “promote uniformity.” Second, each provision is accompanied by an official explanatory comment, analogous to …

A Relational Understanding Of Human Rights: Human Dignity In Social Solidarity, David Hollenbach

Emory Law Journal

No abstract provided.

Normative Systems And Human Rights, Richard S. Kay

Emory Law Journal

No abstract provided.

Activity Levels Of Bat Species At Interstate Highway Sites With And Without Wildlife Underpasses In The Washington Cascades, Jenna Chapman

All Master's Theses

Roads force wildlife to navigate degraded and fragmented habitats across the globe, creating barriers to movement and increasing the risk of mortality. This includes bats, whose movements between foraging and roosting habitats may be impeded by roads. Wildlife crossing structures (WCS) are a common mitigation strategy to increase connectivity, but investigation into bat activity in and around these structures is limited. I investigated bat species presence and activity along Interstate-90 in the Cascade Range of Washington State. My goal was to test whether all bat species found in the nearby forest were also active along the highway, and whether bat …

Dynamics Of Targeted Ransomware Negotiation, Pierce Ryan, John Fokker, Sorcha Healy, Andreas Amann

Research Outputs: 2025-Present

In this paper, we consider how the development of targeted ransomware has affected the dynamics of ransomware negotiations to better understand how to respond to ransomware attacks. We construct a model of ransomware negotiations as an asymmetric non-cooperative two-player game. In particular, our model considers the investments that a malicious actor must make in order to conduct a successful targeted ransomware attack. We demonstrate how imperfect information is a crucial feature for replicating observed real-world behaviour. Furthermore, we present optimal strategies for both the malicious actor and the target, and demonstrate how imperfect information results in a non-trivial optimal strategy …

A Machine Learning Perspective On Fnirs Signal Quality Control Approaches, Andrea Bizzego, Michelle Neoh, Giulio Gabrieli, Gianluca Esposito

Research Outputs: 2025-Present

Despite a rise in the use of functional Near Infra-Red Spectroscopy (fNIRS) to study neural systems, fNIRS signal processing is not standardized and is highly affected by empirical and manual procedures. At the beginning of any signal processing procedure, Signal Quality Control (SQC) is critical to prevent errors and unreliable results. In fNIRS analysis, SQC currently relies on applying empirical thresholds to handcrafted Signal Quality Indicators (SQIs). In this study, we use a dataset of fNIRS signals (N = 1,340) recorded from 67 subjects, and manually label the signal quality of a subset of segments (N = 548) to investigate …

Melatonin As An Immunomodulator In Children With Down Syndrome, Dean Huggard, Lynne Kelly, Amy Worrall, Eleanor Gallagher, Lida Fallah, Lucas Lu Yoo, Fiona Mcgrane, Niamh Lagan, Edna Roche, Joanne Balfe, Derek G. Doherty, Eleanor J. Molloy

Research Outputs: 2025-Present

Background: Down syndrome (DS) is a disorder characterised by marked immune dysfunction, increased mortality from sepsis, chronic inflammation, increased oxidative stress, sleep disturbance and possibly abnormal endogenous melatonin levels. Melatonin has a myriad of immune functions, and we hypothesised that this therapeutic agent could modulate the innate immune system in this cohort. Methods: We investigated neutrophil and monocyte function (CD11b, TLR4 expression by flow cytometry), genes involved in TLR signalling (MyD88, IRAK4, TRIF), the inflammasome (NLRP3, IL-1β), and circadian rhythm (BMAL, CLOCK, CRY) by qPCR, and inflammatory cytokines (IL-2, IL-6, IL-8, IL-18, IL-1β, TNF-α, IFN-γ, IL-10, IL-1ra, VEGF, Epo, GM-CSF) …

Climate Change And Environmental Sustainability Module: Information Booklet, Fozia Parveen, Sara Hassan, Subhan Khan

Books

No abstract provided.

Equine-Assisted Therapy And Learning Interventions With Youth: A Meta-Analysis And Quasi-Experimental Study., Sarah Lovins

Graduate Theses/Dissertations

Equine-assisted psychotherapy interventions have become increasingly used and tested as an alternative or complementary approach with youth. This project presents two studies. The first study consists of an overview of existing reviews and a meta-analysis of controlled and comparison studies on the effectiveness of equine interventions with youth. A comprehensive search and selection procedure produced 3,525 records, from which 56 quantitative studies were identified, and ultimately 16 controlled or comparison studies were selected for inclusion in the meta-analysis. Results showed a statistically significant, medium, and homogenous effect size for the overall effectiveness of equine interventions for youth psycho-social outcomes ( …

Occupational Therapist’S Role In Addressing The Psychological Impacts Of Pain In Clients With Upper Extremity Conditions, Shivangi Patel

Occupational Therapy Capstones

Background & Purpose: The experience of pain is different for every client (Felman, 2020). There are various ways to feel and describe the pain (Felman, 2020). A maladaptive response to pain has been associated with increased pain and physical limitations in clients with upper extremity pain (Verhiel et al., 2019). Upper extremity impairments can result in the disruption of many activities of daily living and instrumental activities of daily living (American Occupational Therapy Association, 2014). Clients with upper extremity pain often resort to maladaptive coping strategies, such as catastrophic thinking (Verhiel et al., 2019). The most common psychological factors related …

Archeota, Fall/Winter 2022, Heather Reinold, Sarah Lewis, Lawrence Mullen, Emma Ruff, Amanda Galvez, Kit Katz, Rachael Sevilla

Archeota

Archeota is a platform for SJSU iSchool students to contribute to the archival conversation. It is written BY students, FOR students. It provides substantive content on archival concerns and issues and promotes professional development in the field of archival studies. Archeota upholds the core values of the archival profession.

Contents:

The Forward Club: Archival Outreach and Community Connections By Sarah Lewis

Putting the Spotlight on Women’s History: The Significance of Reevaluating Historic Site Narratives By Lawrence Mullen

Meet the 2022-2023 Archeota Team

Farm to Folder: Found Ephemera Joins the Dziekanowski Farm Papers Collection By Emma Ruff

An Archivists’ Evolving …

Normative Ambiguity Facing Those Who Flee Death During Times Of War And Pandemic And Who Eventually Return Home, Rory Conces

Philosophy Faculty Publications

We dwell in a world of physical things. When it comes to the environments that we live in, we usually become oriented to the place, and eventually feel at home in it. Facing death during war and pandemic are times of extreme disorientation, and we sometimes exhibit an impulse to flee. It is no wonder that in those desperate times, some with means and ability consider fleeing to a safer place. But are we morally obliged to act in ways that would ask us to sacrifice our deepest personal commitments and projects for others to meet their commitments and projects? …

2022-2023 Undergraduate Bulletin, Rochester Institute Of Technology

RIT Digital Archives

No abstract provided.

2022-2023 Undergraduate Course Descriptions, Rochester Institute Of Technology

RIT Digital Archives

No abstract provided.

2022-2023 Graduate Bulletin, Rochester Institute Of Technology

RIT Digital Archives

No abstract provided.

2022-2023 Graduate Course Descriptions, Rochester Institute Of Technology

RIT Digital Archives

No abstract provided.

Nanomaterials In Theranostics : Therapeutics And Diagnosis Against Infectious Diseases, Unnatiben S. Patel

Dissertations

Nanomaterials-based hybrid nano therapy is gaining attraction as a promising way to treat intracellular bacterial infections. Gold-based nanomaterials have been widely used for biomedical applications such as photothermal therapy (PTT). This thesis discusses the development of a combination therapeutic approach that kills intracellular bacteria in conjunction with photothermal and antibiotic therapy using gold nanorod (GNR) based nano-assembly. This NIR laser-activated nano-assembly delivers antibiotics to the site of infection and offers PTT. The synergistic application of both therapies increases the efficacy of treatment. The protected delivery of antibiotics and their release in the proximity of the bacterial surface decreases off-target toxicity …

Front Matter

Animal Law Review

Front Matter includes Title Page, Masthead, advisors, and Table of Contents for Animal Law Review Volume 28, Issue 1, 2022.

Jebel Mukkabbir, Jerusalem A-9393/2022, Mustafa Hussein

Favissa: Past Archaeological Excavation Reports

During August–September 2022, preliminary trial trenches and a trial excavation were conducted on a private plot in Jebel Mukkabbir (Permit No. A-9393/2022; Map ref. 222688-719/629640-74). The excavation, on behalf of the Israel Antiquities Authority and funded by Mr. Hassin Kara'in, was directed by M. Hossin, with the assistance of N. Sapir and B. Touri (scientific counseling) and Sh. Halevi (photography and photogrammetry).

Rivers Of Power: How A Natural Force Raised Kingdoms, Destroyed Civilizations, And Shapes Our World By Laurence C. Smith (Little, Brown Spark, 2020), Stephen Earsom

Natural Resources Journal

No abstract provided.