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Inclusivity As Explored Through Picture Books, Sarah Boyle

Renée Crown University Honors Thesis Projects - All

No abstract provided.

Amd3100 Administration For The Treatment Of Asherman’S Syndrome In A Murine Model, Pablo Antonio Delis

Yale Medicine Thesis Digital Library

Statement of Purpose

1. Optimize a murine model of Asherman’s Syndrome.2. Assess fertility outcomes in mild Asherman’s Syndrome model mice treated with AMD3100. 3. Determine timing of peak serum and uterine levels of CXCL12 after AS induction. 4. Identify an optimal time point for AMD3100 administration in AS.

Sleep Apnea In Veterans With Schizophrenia: Estimating Prevalence And Impact On Cognition, Stephen Edward Ghazikhanian

Yale Medicine Thesis Digital Library

The cognitive impairments of schizophrenia drive the functional disability of the illness but are difficult to treat. One barrier to effective cognitive interventions may be medical illnesses that compromise cognition and are over-represented in people with schizophrenia. Obstructive sleep apnea (OSA) is treatable, causes reversible impairments in many cognitive domains also affected by schizophrenia, and is likely under-diagnosed in people with schizophrenia. We have estimated the prevalence of OSA in schizophrenia, both by self-report and with a predictive model, and characterized the associations between OSA and cognition and functional capacity in schizophrenia, using a large dataset of 3942 patients with …

The Role Of The Nmda Receptor In Shaping Cortical Activity During Development, Jacob Michael Kayle Lister

Yale Medicine Thesis Digital Library

Currently, it is estimated that neuropsychiatric disorders will affect 20-25% of humans in their lifetime. These disorders are a major cause of mortality, suffering, and economic cost to society. Within this broad class, neurodevelopmental disorders (NDDs), including intellectual disability, autism spectrum disorder, and schizophrenia, are estimated to affect 2-5% percent of the world population. Devastatingly, we lack fundamental treatments for NDDs, which have proved some of the most imposing disorders to understand scientifically. The challenge is twofold: first, NDDs affect the most complex aspects of human cognition; second, pathogenesis begins early in neural circuit development, but we lack predictive biomarkers …

Influence Of Neoadjuvant Chemotherapy Regimen On Breast Reconstruction Outcomes, Olamide Olawoyin

Yale Medicine Thesis Digital Library

Background: Neoadjuvant chemotherapy (NACT) provides a survival advantage in breast cancer. Prior to mastectomy, NACT shrinks tumor size and improves pathological response in breast cancer. Evidence to date has evaluated the impact of chemotherapy on autologous breast reconstruction outcomes as a binary variable. In this study, we evaluate the effect of specific NACT regimens and dosage on the rate of post-operative complications after autologous breast reconstruction. We also evaluate the effect of NACT on circulating immune cells that orchestrate wound healing.Methods: Following IRB approval, patients who underwent NACT and microvascular breast reconstruction at Yale New Haven Hospital between 2013 and …

A Nationwide Assessment Of Disparities In Primary Cleft Lip Repair, Connor J. Peck

Yale Medicine Thesis Digital Library

Purpose: This study examined the impact of patient race or ethnicity on the likelihood of experiencing delays to surgery, post-operative surgical complications, or prolonged hospital stays following primary cleft lip (CL) repair.Methods: Patients who underwent CL repair were identified from two large national databases: the Kids Inpatient Database (KID) and the Pediatric National Surgical Quality Improvement Program (NSQIP) database. Primary outcomes were defined as treatment after 6 months of age, the presence of any surgical complication, and a hospital stay greater than 1 day. Chi-squared analyses were performed to compare outcomes across patients of different race/ethnicity, followed by multivariable logistic …

Job Demands That Influence Organizational Commitment Of Public Safety Telecommunicators, Andre Jones

Walden Dissertations and Doctoral Studies

High job demands mean high turnover for public safety telecommunicators (also known as “9-1-1 call operators” or “emergency dispatch”). Personnel turnover place 9-1-1 call centers in an understaffed situation, which reduces operational effectiveness and increases risk to communities. Though public safety telecommunicators experience work-related stress due to job demands, organizational commitment, and operational impacts, the impact of job demands and its influence on organizational commitment is under-researched. The purpose of this qualitative study was to understand job demands and the resources that influence organizational commitment of public safety telecommunicators. The classical organizational theory of scientific management, or Taylorism, was theoretical …

Calorie Restriction Improves Lipid-Related Emerging Cardiometabolic Risk Factors In Healthy Adults Without Obesity: Distinct Influences Of Bmi And Sex From Calerie™ A Multicentre, Phase 2, Randomised Controlled Trial, Kim M. Huffman, Daniel C. Parker, Manjushri Bhapkar, Susan B. Racette, Corby K. Martin, Leanne M. Redman, Sai Krupa Das, Margery A. Connelly, Carl F. Pieper, Melissa Orenduff, Leanna M. Ross, Megan E. Ramaker, James L. Dorling, Clifford J. Rosen, Irina Shalaurova, James D. Otvos, Virginia B. Kraus, William E. Kraus

Clinical Research Faculty Publications

Background: For many cardiovascular risk factors there is no lower limit to which further reduction will result in decreased disease risk; this includes values within ranges considered normal for healthy adults. This seems to be true for new emerging metabolic risk factors identified by innovative technological advances. Further, there seems to be ever evolving evidence of differential responses to lifestyle interventions by sex and body compositions in the normal range. In this secondary analysis, we had the opportunity to test these principles for newly identified molecular biomarkers of cardiometabolic risk in a young (21–50 years), normal weight healthy population undergoing …

Castor Canadensis Winter 2022, Jedediah Smith Society

Castor Canadensis - Jedediah Smith Society

Newsletter of the Jedediah Smith Society

Bachelor Sketches Invisible Women In Irving’S Domestic Writings, Claudia Stokes

English Faculty Research

This essay examines Washington Irving’s domestic writings of the 1820s, and it argues that Irving devised the sketch as the literary genre of bachelorhood. In lavish, detailed sketches of numerous homes, Irving created a literary counterpart of the still life, but the effect of these sketches depended on the excision of women’s domestic labor and the portrayal of the home in a state of static readiness, with all housework already completed. Irving’s tales, however, often depict women’s hidden domestic activities and show the invisible labors that underlie his sketches. These tales, however, portray women’s housework as a source of terror, …

Being The Bigger Ram: Arable Vs Pastoral Masculinities In The Towneley Mactacio Abel, Daisy E. Black

Medieval Feminist Forum: A Journal of Gender and Sexuality

This article addresses the construction of rural masculine identities through a study of the Towneley manuscript play Mactacio Abel (The Killing of Abel) and the relationships the play stages between human, animal, and land. It argues that the Mactacio Abel places pastoral and arable agricultural labor in competition through the play’s two brothers, and that this competition takes the form of a gendered attack on the masculinity of each. The article begins with Cain’s arable farming and how the character’s antagonistic relationship with the earth hints at his failures as laborer and as a man. It examines Cain’s …

Characterizing The Internal Porous Structure Of Equine Proximal Sesamoid Bones Subjected To Race Training Using Fast Fourier Transforms, Joseph Erik Davis

Theses and Dissertations--Biomedical Engineering

The equine racing industry is one of the main proponents in Kentucky’s economic infrastructure. In this industry there has come a need to investigate the nature of the proximal sesamoid bone (PSB). Breakdowns involving the PSBs are the leading cause in racehorse deaths in the industry, with still little known about what causes this bone to fracture. This study seeks to shed insight by investigating the internal structure of the PSB. Using microCT scanning, the internal porous structure was captured. From there, noticeable differences in the pores were noticed and quantified using fast Fourier transform (FFT) analysis.

The dominant peak …

Sewer Vapor Intrusion Pathway: Simulation Of Indoor Piping Systems And Operation Of Aroma-Voc Gas Analyzer, Hong Cheng Tay

Theses and Dissertations--Civil Engineering

Vapor Intrusion (VI) is a transport phenomenon that occurs when contaminants migrate from sub-surface sources into indoor spaces. Sewer tunnels, plumbing connections, and piping infrastructures can be important contributors to an increased potential of VI in a site, which results in indoor concentrations of volatile organic compounds (VOC). In the present work, the topic of sewer VI pathways were investigated through a prototype made from various types of indoor plumbing pipe fittings. This prototype simulates indoor piping systems and determine whether air and VOC were escaping through the pipe fittings. Moreover, this study is the first effort to use a …

Investigation Of Pfas Exposure Risks In Kentucky Using Mapping Tools, Sweta Ojha

Theses and Dissertations--Civil Engineering

Per- and polyfluoroalkyl substances (PFAS), a group of environmentally-persistent compounds, are environmentally ubiquitous and challenging to remediate. Several studies show that PFAS are detected in drinking water systems when sampling is conducted, making human exposure via drinking water an important health consideration. This research: 1) develops a mapping tool for prioritizing sampling locations; 2) establishes a method for making GIS data and meta(data) in the mapping tool accessible; 3) fosters decision making by integrating knowledge brokering and the alignment interest and influence matrix (AIIM). The tool developed is this research is a geospatial and statistical PFAS hot-spot screening model that …

Understanding The Differences Between Industry Objectives And Institutional Learning, Kristen Schell

Theses and Dissertations--Civil Engineering

To combat understaffing in the construction industry, it is necessary to employ the best candidates possible. By identifying the most desirable skills in a construction employee from an industry perspective, institutional learning can better prepare graduates for the construction workforce. Currently there exists an information gap in the objectives of the construction industry and institutional learning. This gap produces graduates, professors, and employers with expectations that do not align. Reducing this gap will aid in the success of hiring recently graduated construction students who can meet the ever-changing demands of the industry. Construction students who are fresh out of college …

"Wearing A Mask To Each Other": Masculinity & The Public Eye In Victorian Sensation Fiction, Shannon Branfield

Theses and Dissertations--English

Sensation fiction, as a genre, offers a field to explore the ways in which ideologies of masculinity are negotiated, contested, and enforced. The Victorian man has no respite from social surveillance; the public is always watching, always evaluating the performance. As these sensation fiction novels build on each other, a portrait of male claustrophobia in response to unceasing surveillance is revealed. The pressure this constant scrutiny puts on Victorian men is immense and sensation novels derive many thrilling plot twists from the dramatic lengths men to which men must go to protect themselves from this gaze. These habits persist even …

How To Live Life All The Way Up Learning Life Skills From Literary Characters, Sue N. Mize

Theses and Dissertations--English

In this essay, using the theories of psychiatrist, Eric Berne and his script theory; psychoanalyst, Carl Jung and his archetypes and mandalas; as well as the Native American Medicine Wheel; and the Hindu notion of the kundalini, I analyze the psychological development of Adele Quested of E.M. Forster’s A Passage to India (1924) and Anna Wulf of Doris Lessing’s The Golden Notebook (1962). Adela Quested goes to India seeking the real India and while engaging the archetype of the Lover discovers her real Self. While in India she metaphorically walks the Medicine Wheel and discovers that to be …

Warriors, Mothers, And Queens: Weighty Women Of Myths And Legends, Betsy Packard

Theses and Dissertations--English

Because traditional stories, myths, and legends have a patriarchal orientation, often portraying women as negative or weak characters, post-modern literary criticism calls for a feminist response. These poems are written in the genre of feminist revisionist mythology. Through the medium of poetry, women in these stories are provided with voices outside of the previously accepted patriarchal framework and challenge the exclusionary theories of Joseph Campbell. The stories are told through a perspective informed by feminist theory.

The Reflective Age: Nostalgia At The End Of History, Zachary Griffith

Theses and Dissertations--English

This project investigates the ways in which nostalgic American media of the last decade reflects the sociopolitical conditions of the end of history. It begins with the assertion that the end of history represents a confounded, contradictory moment in which large-scale political change is relatively scarce, and belief in a progressive future has largely been abandoned, while cultural change has also accelerated at a pace never before seen––spurred on, in particular, by the constant return of dead styles and dormant IP. In other words, it seems as if nothing is changing and everything is changing simultaneously. The recent boom in …

Fantasies Of Race And Place: White Nationalist And Alt-Right Undercurrents In Fantasy Roleplaying Games, Mark Hines

Theses and Dissertations--English

Representations of fantasy settings in roleplaying games often draw upon understandings of the medieval and early Renaissance world. This dynamic often extends to racial politics in such worlds. For the contemporary roleplaying game, this often means that game mechanics are built around race, species, or gender. Often, players interpret such mechanics as a means of bioessentializing race or practicing stereotypes rooted in Eurocentric morality and values.

This thesis examines the underlying rhetoric and implicit stakes by which race in fantasy worlds overlaps with the rhetoric and proposed stakes of White Nationalist and Alt-right actors. As fantasy roleplaying games, and especially …

Fleshcrawl, Shanita Jackson

Theses and Dissertations--English

I am fascinated with the spiritual, physical, and psychological experiences that occur when one’s flesh crawls. The experiences, akin to inverted goosebumps, result from provocations of the senses or of the mind. James Blake’s latest album, for example, triggers my flesh to crawl. The art on the album cover depicts a decaying body turned into a canyon-like labyrinth. In undergrad, attempts to conceptualize slave-deck diagrams disturbed my flesh to crawl. I am intrigued by how anxiety, epigenetics, and superstition all factor into the subjective intensities of this collective experience. As it seems, circumstance heightens the severity and frequency of the …

Investigating The Role Of Chd7 And Sox11 In Retinal Cell Development And The Ocular Complications Of Charge Syndrome, Laura Krueger

Theses and Dissertations--Biology

Proper formation of the visual system requires the precise interaction of several embryonic cell lineages, including the neuroectoderm (forms the retina and retinal pigment epithelium), surface ectoderm (forms the lens), mesoderm and cranial neural crest cells (form the ocular blood vessels and anterior ocular structures). When this process is disrupted structural birth defects such as coloboma result, leading to pediatric visual deficits. Ocular developmental defects are often present in larger syndromic disorders. One example is CHARGE syndrome, a genetic disorder characterized by coloboma, heart defects, choanal atresia, growth retardation, genital abnormalities, and ear abnormalities. Pathogenic variants in CHD7 have been …

Metabolic Diversity Among Fibroblasts From Regenerating And Non-Regenerating Mammals, Ebenezer Aryee

Theses and Dissertations--Biology

Regeneration is a wound repair process that terminates in the restoration of tissue function and structure. Fibroblasts play pivotal roles in regenerative and fibrotic wound repair. Reports of extensive regenerative ability in mammals have been historically rare, but more recently spiny mice (Acomys) have emerged as a bona fide model of complex tissue regeneration. Recent work has indicated that fibroblasts from regenerators (Acomys and Oryctolagus) are more resistant to reactive oxygen species (ROS)-induced senescence compared to non-regenerating species, suggesting the influence of intrinsic cellular states on the fate of wound repair. Determining the basal metabolic signature …

Estrogen Regulation Of Daily Metabolic Rhythms In Female Mice, Oluwabukola Omotola

Theses and Dissertations--Biology

Circadian rhythms are approximately 24-hour cycles of behavior, physiology, and gene expression. In mammals, these circadian rhythms are generated by clocks located in nearly every tissue in the body. The function of circadian clocks is to synchronize physiology and behavior with environmental cycles such as the light-dark cycle. After menopause, when circulating levels of estrogens are very low, women are more susceptible to obesity comorbidities such as metabolic syndrome and cardiovascular disease, suggesting that estrogens regulate these processes. Estrogens could protect females from metabolic dysfunction by regulating circadian rhythms. Consumption of diets that are high in fat contribute to obesity. …

The Revised Systematics And Paleoecology Of The Devonian Stemless Crinoid Genus Edriocrinus Hall, 1858, Catherine E. Herbert

Theses and Dissertations--Earth and Environmental Sciences

New morphological observations of Edriocrinus Hall, 1858, enable a modern, holistic view of this unusual crinoid genus, previously included in the Superorder Flexibilia (Zittel, 1895) Wright et al., 2017. Re-analysis of Edriocrinus suggests that the genus should now be assigned to the Order ‘Dendrocrinida’ within the Magnorder Eucladida Wright, 2017 based on the five infrabasals, single radianal in the cup, absent anal sac, and non-pinnulate arms with rectangular uniserial brachials. Moreover, examination of the slight variations separating the current 14 Edriocrinus species indicates that these “species” are likely ecophenotypes. The current Edriocrinus species are revised based on firmly bound calyx …

Tryptophan-Like Fluorescence And Non-Point Source Pollution In Karst Basins, Inner Bluegrass Region, Kentucky, Ryan Dapkus

Theses and Dissertations--Earth and Environmental Sciences

Typically, the degree of fecal contamination of water is assessed by the concentration of thermotolerant coliforms, like E. coli. This method is time-consuming, taking > 18 hours between the start of incubation and subsequent enumeration. The current study examines the utility of monitoring tryptophan-like fluorescence (TLF) using in-situ fluorometers as a proxy for fecal contamination, particularly E. coli. Relative timing of discharge peaks and TLF peaks is considered, as well as differences in E. coli concentrations and major anion concentrations between two different basins that were monitored weekly. Results indicate that TLF is somewhat useful in the prediction of …

The Role Of Sox4 In Ocular Morphogenesis And Retinal Differentiation, Rebecca Petersen

Theses and Dissertations--Biology

Visual impairment ranges from mild forms that can be corrected with glasses to more severe cases that result in permanent loss of vision. Microphthalmia, anophthalmia, and coloboma (collectively referred to as MAC) account for 11% of cases of pediatric blindness and are a result of improper ocular morphogenesis. Retinitis Pigmentosa (RP) is a retinal degenerative disease that affects 1 in 3000 people worldwide. It is a progressive disorder that initially begins with loss of vision in low light settings due to rod photoreceptor degeneration but progresses to complete blindness upon loss of cone photoreceptors. Currently, there is no cure for …

Gender And Remittances: Lived Experiences Of Women In Oaxaca, Mexico, Araby Smyth

Theses and Dissertations--Geography

This dissertation project analyzes the ways that migration and remittances, the money that migrants send to people in their place of origin, intersect with the political and social dynamics in an Indigenous community in the Isthmus of Tehuantepec region of Oaxaca, Mexico. Drawing on 16 months of ethnographic fieldwork, which included semi-structured interviews and participant observation alongside historical archival investigation, this dissertation examines the following questions: What international organizations, national government, and private sector policies govern remittances? How does Indigenous collective work and communal governance shape remittance management? How do the responsibilities of family members shift with migration and how …

"It's Not Rainbows And Unicorns": Regulated Commodity And Waste Production In The Alberta Oilsands, Hugh Deaner

Theses and Dissertations--Geography

This dissertation examines the regulated oilsands mining industry of Alberta, Canada, widely considered the world’s largest surface mining project. The industrial processes of oilsands mining produce well over one million barrels of petroleum commodities daily, plus even larger quantities of airborne and semisolid waste. The project argues for a critical account of production concretized in the co-constitutional relations of obdurate materiality and labor activity within a framework of regulated petro-capitalism. This pursuit requires multiple methods that combine archives, participant observation, and semi-structured interviews to understand workers’ shift-to-shift relations inside the “black box” of regulated oilsands mining production where materiality co-constitutes …

Affective Registers Of Displacement: Eviction And Gentrification In Post-Earthquake Mexico City, Jess Linz

Theses and Dissertations--Geography

This dissertation contributes to understandings of the affective and emotional register of urban politics by analyzing how affective dynamics influence struggles over displacement in Mexico City amid rapid gentrification and in the wake of the 2017 earthquake. Drawing primarily on feminist and queer/cuir theory and trauma studies, I aim to show the relevance of an often-overlooked dimension of urban political struggles. This dissertation is based on data collected through ethnographic methods over the course of 2018-2021. The primary source of data is long-form semi-structured interviews, supported by participant observation in meetings, protests, and WhatsApp groups. The dissertation studies the following …