Digital Commons Network^™

Variation In Phenotype, Genotype, And Somatic Diversity Among Asexual Schmidtea Mediterranea Planarians, S. Kershenbaum, Danielle Ireland, Ziad Sabry , '20, Christina Rabeler, Vir Shetty , '22, A. Aboobaker, Eva-Maria S. Collins

Biology Faculty Works

Most multicellular life reproduces sexually, utilizing a single-celled stage that acts as a genetic bottleneck. This bottleneck limits the evolution of selfish cell adaptations by ensuring all cells descend from a single progenitor. We investigated an obligately asexual strain of Schmidtea mediterranea planarians that reproduces by self-bisection and lacks a single-cell bottleneck. Using 2.5 yearlong data on planarian reproductive behavior combined with genotyping, we revealed two previously undescribed genetically distinct substrains within the CIW4 strain. One substrain showed reduced fitness, which correlated with substantial losses of heterozygosity and increased somatic diversity. By genotyping consecutive head offspring over multiple generations, we …

Advance S In The Generation And Transport Behavior Of Secondary Hazards From Food Packaging Sterilization, Mengjia Ren, Ye Liu, Jinpeng Wang, Shuang Bi

Journal of Food Science and Biotechnology

Food packaging sterilization is an important technical means to avoid the spread of SARS-CoV- 2 and the cross-contamination of foodborne viruses.However,the secondary hazards generated after sterilization are complex and have different characteristics,and a wide range of factors affect the formation of these hazards.The studies about the migration behavior of secondary hazards from packaging materials to food remain to be reviewed.Therefore,the author systematically reviewed the correspondence between sterilization technologies and secondary hazards generated after food packaging sterilization,the characteristics of secondary hazards,the factors affecting the formation of secondary hazards,and the detection technologies of secondary hazards.By outlining the classical migration model,the author summarized …

Oral Administration Of Lacticaseibacillus Paracasei Ccfm 1433 Boosts Host Immunity To Prevent Candida Albicans Infections, Xinya Zhang, Qiuxiang Zhang, Xin Tang, Bingyong Mao, Jianxin Zhao, Shumao Cui

Journal of Food Science and Biotechnology

[Objective ] This study aims to explore the role of Lactobacillus in enhancing host immunocompetence and preventing vaginal infections with Candida albicans.[Method ] A human vaginal epithelial cell (VK2/E6E7 cell) model was employed to screen the most potent strain among ten vaginal Lactobacillus isolates in inducing the antimicrobial peptide LL- 37.A mouse model of vaginal infection with Candida albicans was established.The effects of oral administration of the selected Lactobacillus strain on vaginal mucosal immunity,systemic inflammatory balance,and vaginal microbiota homeostasis were systematically evaluated using hematoxylin-eosin (HE) staining,ELISA,qPCR,and 16S rRNA sequencing.[Result ] Both t he cell lysate and fermentation supernatant of Lacticaseibacillus …

The Files Are In The Computer: On Copyright, Memorization, And Generative Ai, A. Feder Cooper [email protected], James Grimmelmann

Chicago-Kent Law Review

No abstract provided.

Creative Machines: Generative Artificial Intelligence And Copyright Law, Ryan Abott, Elizabeth Rothman [email protected]

Chicago-Kent Law Review

No abstract provided.

Artificial Intellectual Property, Daniel J. Gervais

Chicago-Kent Law Review

No abstract provided.

Differential Interferon Synthesis And Signaling Between Parainfluenza Virus Acute And Persistently Infected Cells, Vonisha Kaigler

Graduate Thesis and Dissertation post-2024

RNA virus infections can transition from an initial acute infection to a prolonged or persistent infection, in which infected cells survive and continue to produce progeny virus. This presents a major clinical problem as persistently infected (PI) cells extend viral shedding, maintain inflammation, and provide potential sources for new viral variants. The RNA virus, Parainfluenza virus 5 (PIV5), with mutations in the P/V gene region (P/V mutant) is a strong inducer of antiviral responses. Interestingly, over time, there is an emergence of cells that survive as P/V mutant PI cells. Given that changes in innate immune signaling pathways can occur …

'How To Mother': Televisual Reimaginings Of Black Matriarchy In The Real Housewives Of Potomac, Kalijah Rahming

Graduate Thesis and Dissertation post-2024

Since the initial launch of The Real Housewives of Orange County in 2006, Bravo’s The Real Housewives franchise has soared to previously unimaginable heights. With 11 American installments, 30 international adaptations, and 25 current spin-offs, it is clear that even viewers who are relatively unfamiliar with The Real Housewives franchise may find themselves inadvertently swept up in their world due to the popularization of their catchphrases and gifs on social media platforms like Instagram, Twitter, and Facebook. In addition to carefully shaping popular culture, members of this franchise have even altered the conditions of the entertainment industry’s practices for the …

The Path Of Peace: Non-Violent Methods Of Play In Indie Video Game History, Ryu R. Yamamoto

Graduate Thesis and Dissertation post-2024

This research project investigates the cultural and historical significance of independently published Japanese bullet-hell/danmaku games from the 2000s and 2010s. This project highlights gaps in current game histories, particularly surrounding the influence of these games on heralded contemporary titles like Undertale (2015). The significance of independently published “doujin” Japanese digital media, notably the Touhou Project series, is often overlooked in American game studies contexts. Examining these underexplored games aims to enrich the understanding of cultural-historical games research, particularly in positioning lesser-known and lower-budget games, and contribute to the broader discourse on cross-cultural interactions within the gaming community. Comparative analyses of …

A Forgotten Kairos: Rhetorical Memory In 16th Century Europe, Phillip Martin

Graduate Thesis and Dissertation post-2024

In 16^th century Europe the nearly 2000-year-old discipline of rhetoric, still a pillar of education, underwent significant change. One of the more curious changes occurred in rhetoric’s subdivision known as memory, memoria, that is, memory’s “artificial” cultivation. During the 16^th century rhetorical memory was paradoxically both maximized and marginalized as a discipline. And by the early 17^th century memoria was all but extinct as a branch of rhetoric. The causal mechanisms of this transformation remain underexamined, particularly by rhetoric and composition scholars, and most explanations remain unclear and uncompelling. Accordingly, this thesis attempts a new approach …

Preserving Florida History In 3d: A Digital Public History Project Preserving Paleo-Native American Artifacts And Jack West Architecture From Warm Mineral Springs, Florida, Trevor D. Colaneri

Graduate Thesis and Dissertation post-2024

This thesis project examines low-cost photogrammetry and 3D walkthrough tours to preserve a collection of artifacts and buildings from Warm Mineral Springs, Florida. The documented objects and structures consist of a small collection of artifacts from Warm Mineral Springs currently held by Florida’s Bureau of Archaeological Research and three buildings designed by noted architect Jack West, a Sarasota School of Architecture member, which suffered extensive damage from a category five hurricane in 2022. Warm Mineral Springs is an archaeologically significant site and is one of the few sites in Florida that demonstrate significant paleo-Native American cultural remains that has also …

Investigating The Role Of Selenium-Dependent Stickland Reactions In Clostridioides Difficile Bioenergetics, Dominika Dzurny

Graduate Thesis and Dissertation post-2024

Clostridioides difficile is an anaerobic, spore-forming bacterium and one of the leading causes of antibiotic- associated diarrhea. Colonization depends on the metabolism of certain nutrients in the host gut, namely amino acids and carbohydrates. C. difficile ferments amino acids as an integral part of its metabolism via Stickland reactions, utilizing the selenoproteins D-proline reductase (Prd) and glycine reductase (Grd) to generate energy. Specificity of selenocysteine incorporation reflects the intracellular levels of selenophosphate, the activated selenium donor synthesized by selenophosphate synthetase (SelD). SelD is coincidentally a selenoprotein itself, containing a UGA codon at position 17 (Sec-17). The functional and physiological importance …

Emojis As Text Technology: Between Visual Paradigm And Cultural Revolution, Hanan Hafiz

Graduate Thesis and Dissertation post-2024

Emojis, as a broader communication phenomenon, have gained widespread usage, significant adaptation, and considerable academic attention due to their role in providing semiotic cues and online gestures within computer-mediated communication. This study aims to trace their development and evolution using the text technologies framework. This approach examines the systematic use of emojis, with particular emphasis on their extensive evolution by historically contextualizing their usage, trends, and cultural interactions. Anchored in this conceptual approach, the study draws on the taxonomy of text technology developed by Treharne and Willan, analyzing the evolution of emojis through four key dimensions: intentionality, materiality, functionality, and …

It's Been Here All Along: Increasing Discomfort In Immersive Horror Puzzle Experiences Without Jump Scares, Brittany R. Porthouse

Graduate Thesis and Dissertation post-2024

This thesis seeks to utilize horror themes in a puzzle-based themed experience without the usage of jump scares. By alerting the body’s startle response once a puzzle is completed with a sudden loud noise or visuals, many horror-themed escape rooms utilize the jump scare tactic to heighten their guests’ adrenaline. While this technique is often effective in eliciting a reaction from participants, the effects are temporary– and sometimes hinder participants’ desire to fully interact with the environment. By primarily using the experience’s narrative and environment to illicit a fear response in guests, as opposed to using the consequences of their …

Copyright Re-Alignment: The Growth Of New Works Outside The Copyright System, Edward Lee

Chicago-Kent Law Review

No abstract provided.

Research Progress In Phytosterols (Esters ) And Their Application In Food, Shuang Mei, Huibing Luo, Tian Gan, Yonggang Qi, Chunmei Li, Chao Wang, Zao Liu

Journal of Food Science and Biotechnology

Phytosterols esters are a type of compound synthesized through the esterification reaction between phytosterols and fatty acids.To clarify the research and application of phytosterols (esters ),the author provided an overview of their structural characteristics,synthesis methods,and physiological functions.Additionally,it was elucidated that phytosterols (esters ),as functional food ingredients,play a significant role in reducing cholesterol levels and exhibiting antioxidant properties in the human body.By delving into the bioactivity of phytosterols (esters ) and enhancing peopl e’s awareness of their nutritional value,this study makes an outlook on the research and application prospects of phytosterols (esters ) in food,thereby providing a crucial theoretical basis for …

Establishment Of A Hplc-Ms/Ms Method For Determination Of Cethromycin Residue In Poultry Eggs, Chenyang Chang, Liangzi Wang, Le Wang, Kai Chang, Jiao Shan, Xiao Wang, Liqiang Guo

Journal of Food Science and Biotechnology

[Objective ] This study aims to establish a method for determining the residual amount of cethromycin in poultry eggs based on high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS ).[Method ] Four representative poultry eggs (chicken eggs,duck eggs,goose eggs,and quail eggs ) were selected as the research matrices.Cethromycin was extracted with Mcllvaine-Na 2EDTA buffer solution,purified by hydrophilic-lipophilic balanced polymer solid-phase extraction column (HLB ),separated by a C 18 column with 0.1% (volume fraction ) formic acid water and acetonitrile as the mobile phase,and determined by HPLC-MS/MS in the multiple reaction monitoring (MRM ) mode combined with an external standard method.[Result ] …

Bifidobacterium Adolescentis Fhnfq 5m4 Modulates Gut Microbiota And Alleviates Colitis In Mice, Yi Wang, Liming Huang, Xihua Yu, Liuruolan Li, Wenwei Lu, Hongchao Wang, Zhijian Zhang

Journal of Food Science and Biotechnology

[Objective ] This study aims to verify and screen the Bifidobacterium adolescentis strains with vitamin A (VA) metabolic capacity,and investigate their effects on colitis symptoms and gut microbiota in mice.[Method ] The VA metabolic capacity of a panel of Bifidobacterium adolescentis strains was evaluated through in vitro fermentation,and the strain with the highest VA metabolic capacity was ultimately selected.This strain was administered orally to mice with dextran sulfate sodium (DSS )-induced colitis for 6 consecutive days.After the intervention,histopathological changes in the colonic tissue were assessed,and the levels of intestinal injury markers in the serum and cytokines,antioxidant enzymes,and retinoic acid (RA) …

Imsa Summer Symposium 2025, Student Inquiry And Research (Sir)

Summer Symposium

For nearly four decades, IMSA has worked to advance the human condition through educational innovation. The Summer Symposium is our annual showcase for the research projects that were conducted in IMSA’s experiential learning programs between May and August. These programs include Student Inquiry and Research (SIR), IN2 Business Internships, and the Student Research and Experiential Learning Opportunity (SRELO) program.

Cover Design

Luke Berryman

The Mythic Circle #47

The Mythic Circle

No abstract provided.

Squaring The Sphinx, L. E. Smith

The Mythic Circle

No abstract provided.

Enchanted Leaves, Lawrence Buentello

The Mythic Circle

No abstract provided.

The Last Mushroom Knight, Cameron Sauder

The Mythic Circle

No abstract provided.

The Wings Of Attachment, Nez Chew

The Mythic Circle

No abstract provided.

The Prizing Coat, Evan Wellbrock

The Mythic Circle

No abstract provided.

The Forest Song, Deborah Shrimplin

The Mythic Circle

No abstract provided.

Sun And The Spandrel, Jared M. Bentley

The Mythic Circle

No abstract provided.

The Ninth Moon, Shefali Mathew

The Mythic Circle

No abstract provided.

Diverse Cell Types Establish A Pathogenic Immune Environment In Peripheral Neuropathy, Julie Choi

Arts & Sciences Graduate Student Theses and Dissertations

Neuroinflammation plays a complex and context-dependent role in many neurodegenerative diseases. We identified a key pathogenic function of macrophages in a mouse model of a rare human congenital neuropathy in which SARM1, the central executioner of axon degeneration, is activated by hypomorphic mutations in the axon survival factor NMNAT2. Macrophage depletion blocked and reversed neuropathic phenotypes in this sarmopathy model, revealing SARM1-dependent neuroimmune mechanisms as key drivers of disease pathogenesis. In this study, we investigated the impact of chronic subacute SARM1 activation on the peripheral nerve milieu using single cell/nucleus RNA-sequencing (sc/snRNA-seq). Our analyses reveal an expansion of immune cells …

Summer Symposium 2025, Student Inquiry And Research (Sir)

IMSAloquium Event Booklets

For nearly four decades, IMSA has worked to advance the human condition through educational innovation. The Summer Symposium is our annual showcase for the research projects that were conducted in IMSA’s experiential learning programs between May and August. These programs include Student Inquiry and Research (SIR), IN2 Business Internships, and the Student Research and Experiential Learning Opportunity (SRELO) program.