Digital Commons Network^™

Food Plants With Toxic Properties, James P. Smith Jr

Botanical Studies

No abstract provided.

Mechanically Injurious Plants, James P. Smith Jr

Botanical Studies

No abstract provided.

An Annotated List Of The Poisonous And Injurious Vascular Plants Of The United States, James P. Smith Jr

Botanical Studies

No abstract provided.

Poisonous Plants: A Glossary Of Commonly Used Terms, James P. Smith Jr

Botanical Studies

No abstract provided.

Stat6 Suppression Prevents Bleomycin-Induced Dermal Fibrosis, Hua Sun, Ashish Damania, Megan L Mair, Eniola Otukoya, Yi-Dong Li, Katherine Polsky, Yuying Zeng, Jeremiah A Alt, Martin J Citardi, David B Corry, Amber U Luong, John Morgan Knight

Faculty, Staff and Student Publications

Unified airway disease, including concurrent asthma and chronic rhinosinusitis (CRS), is a common, but poorly understood disorder with no curative treatment options. To establish a murine model of chronic unified eosinophilic airway inflammation, mice were challenged with Aspergillus niger, and sinonasal mucosa and lung tissue were evaluated by immunohistochemistry, flow cytometry, and gene expression. Inhalation of A niger conidia resulted in a Th2-biased lung and sinus inflammation that typifies allergic asthma and CRS. Gene network and pathway analysis correlated with human disease with upregulation of not only the JAK-STAT and helper T-cell pathways, but also less expected pathways governing …

Advancements In The Quest To Map, Monitor, And Manipulate Neural Circuitry, Jessica L Swanson, Pey-Shyuan Chin, Juan M Romero, Snigdha Srivastava, Joshua Ortiz-Guzman, Patrick J Hunt, Benjamin R Arenkiel

Duncan NRI Faculty and Staff Publications

Neural circuits and the cells that comprise them represent the functional units of the brain. Circuits relay and process sensory information, maintain homeostasis, drive behaviors, and facilitate cognitive functions such as learning and memory. Creating a functionally-precise map of the mammalian brain requires anatomically tracing neural circuits, monitoring their activity patterns, and manipulating their activity to infer function. Advancements in cell-type-specific genetic tools allow interrogation of neural circuits with increased precision. This review provides a broad overview of recombination-based and activity-driven genetic targeting approaches, contemporary viral tracing strategies, electrophysiological recording methods, newly developed calcium, and voltage indicators, and neurotransmitter/neuropeptide biosensors …

Quantification Of Behavioral Deficits In Developing Mice With Dystonic Behaviors., Meike E Van Der Heijden, Jason S Gill, Alejandro G Rey Hipolito, Luis E Salazar Leon, Roy V Sillitoe

Duncan NRI Faculty and Staff Publications

Converging evidence from structural imaging studies in patients, the function of dystonia-causing genes, and the comorbidity of neuronal and behavioral defects all suggest that pediatric-onset dystonia is a neurodevelopmental disorder. However, to fully appreciate the contribution of altered development to dystonia, a mechanistic understanding of how networks become dysfunctional is required for early-onset dystonia. One current hurdle is that many dystonia animal models are ideally suited for studying adult phenotypes, as the neurodevelopmental features can be subtle or are complicated by broad developmental deficits. Furthermore, most assays that are used to measure dystonia are not suited for developing postnatal mice. …

Functional Studies Of Genetic Variants Associated With Human Diseases In Notch Signaling-Related Genes Using Drosophila, Sheng-An Yang, Jose L Salazar, David Li-Kroeger, Shinya Yamamoto

Duncan NRI Faculty and Staff Publications

Rare variants in the many genes related to Notch signaling cause diverse Mendelian diseases that affect myriad organ systems. In addition, genome- and exome-wide association studies have linked common and rare variants in Notch-related genes to common diseases and phenotypic traits. Moreover, somatic mutations in these genes have been observed in many types of cancer, some of which are classified as oncogenic and others as tumor suppressive. While functional characterization of some of these variants has been performed through experimental studies, the number of ‘variants of unknown significance’ identified in patients with diverse conditions keeps increasing as high-throughput sequencing technologies …

Investigation Of Urinary Metabolomics In A Phase I Hookworm Vaccine Trial In Gabon, Madeleine Eunice Betouke Ongwe, Yoanne D Mouwenda, Koen A Stam, Peter G Kremsner, Bertrand Lell, David Diemert, Jeff Bethony, Maria E Bottazzi, Peter J Hotez, Remko V Leeuwen, Martin P Grobusch, Ayola A Adegnika, Oleg A Mayboroda, Maria Yazdanbakhsh

Center for Medical Ethics and Health Policy Staff Publications

Metabolomics provides a powerful tool to study physiological changes in response to various perturbations such as vaccination. We explored whether metabolomic changes could be seen after vaccination in a phase I trial where Gabonese adults living either in rural or semi-urban areas received the subunit hookworm vaccine candidates (Na-GST-1 and Na-APR-1 (M74) adjuvanted with Alhydrogel plus GLA-AF (n = 24) or the hepatitis B vaccine (n = 8) as control. Urine samples were collected and assayed using targeted 1H NMR spectroscopy. At baseline, a set of metabolites significantly distinguished rural from semi-urban individuals. The pre- and post-vaccination comparisons indicated significant …

Evolution Of Genetic Networks For Human Creativity, I Zwir, C Del-Val, M Hintsanen, K M Cloninger, R Romero-Zaliz, A Mesa, J Arnedo, R Salas, G F Poblete, E Raitoharju, O Raitakari, L Keltikangas-Järvinen, G A De Erausquin, I Tattersall, T Lehtimäki, C R Cloninger

Staff and Researcher Publications

The genetic basis for the emergence of creativity in modern humans remains a mystery despite sequencing the genomes of chimpanzees and Neanderthals, our closest hominid relatives. Data-driven methods allowed us to uncover networks of genes distinguishing the three major systems of modern human personality and adaptability: emotional reactivity, self-control, and self-awareness. Now we have identified which of these genes are present in chimpanzees and Neanderthals. We replicated our findings in separate analyses of three high-coverage genomes of Neanderthals. We found that Neanderthals had nearly the same genes for emotional reactivity as chimpanzees, and they were intermediate between modern humans and …

"My 'Eh' Is Authentic"; Commodification Of Language And Identity In Michigan's Upper Peninsula, Meg Elaine Perry

English

The following paper is an investigation of the historic, economic, social, and ideological processes that have shaped dialect awareness in Michigan’s Upper and Lower peninsulas. The goal of this study is to explore dialect perceptions between “Yoopers” and “Trolls” with a specific focus on the tourist industry and material items. This work performs textual analysis of various commodified dialect features in Michigan’s Upper Peninsula to examine the complex relationship between language use and identity. Secondary research is used to synthesize the historical, political, and cultural circumstances resulting in present day dialect features, while textual analysis reveals that material artifacts circulate …

Thermal Biology, Overwintering, And A Degree-Day Model For The Adult Emergence Of The Red Sunflower Seed Weevil (Coleoptera: Curculionidae), Shawna Pantzke

Entomology

Red sunflower seed weevil, Smicronyx fulvus LeConte, is a univoltine seed-feeding weevil that is a primary pest of cultivated sunflower, Helianthus annuus, in North America, especially within the upper Great Plains region. This pest spends its final larval stage overwintering in the soil before pupating in the summer and emerging as an adult to feed on sunflower pollen and lay eggs in developing achenes. Larval feeding can damage of up to 83% of seeds on a head. Growers typically manage S. fulvus by using insecticides; however, early planting dates have also been demonstrated to reduce weevil damage. It is important …

“I Am A Priest”: The Construction And Adaptability Of Identity In The Last Report On The Miracles At Little No Horse, Majalisa Rose Sarkar

English

The following paper investigates the construction and adaptability of identity, especially in regard to gender, religion, and culture in Louise Erdrich’s novel The Last Report on the Miracles at Little No Horse. The goal of this paper is to explore how a broader understanding of one aspect of identity, can lead to a more complex understanding of other aspects of identity. This work performs textual analysis to examine how the character Agnes/Father Damien’s gender and their religious persona are constructed in the novel as they blend their religious beliefs and their masculinity/femininity as well as how this causes them to …

Community Development Supporting Ecological Conversion, As Identified In Laudato Si’: On Care For Our Common Home, Anne Jennings

Theses

In this extraordinary time of multiple, intersecting crises with compounded costs in social, economic, and environmental degradation, calls for transformative change are emerging from all levels of humanity – global to local. Within that setting, my study concentrated on investigating change at a local level to address the research question ’How can community development theory and practice contribute to ecological conversion, as identified in Laudato Si’: On Care for Our Common Home?’

Since its release, Laudato Si’ has provoked considerable academic/theological and scientific/environmental debate that does not necessarily contain local people’s views and everyday lived experiences, given their often-limited access …

Indigenous Ecocriticism And The Relationships Between Humans And Nature In Catherine Knutsson’S Shadows Cast By Stars, Kerri Nicole Nelson

English

In the midst of the climate crisis, Young Adult dystopian literature offers a glimpse of the possible dark futures in store for all of us. Yet Indigenous Young Adult literature revises the natural world not as the enemy of the survival of human beings, but as a possible ally. In Cassandra Knutsson’s Shadows Cast by Stars, a plague is raging and Indigenous blood is key to human survival. Through her journey to save her community, Cassandra demonstrates how she builds a more positive relationship with nature. By offering alternative possibilities for how to treat and interact with nature, Shadows Cast …