Digital Commons Network^™

Proceedings From The Albert Charitable Trust Inaugural Workshop On 'Understanding The Acute Effects Of Exercise On The Brain', Jill N. Barnes, Jeffrey M. Burns, Marcas M. Bamman, Sandra A. Billinger, Sue C. Bodine, Frank W. Booth, Patrice Brassard, Tameka A. Clemons, Paul J. Fadel, Paige C. Geiger, Swathi Gujral, Jacob M. Haus, Scott E. Kanoski, Benjamin F. Miller, Jill K. Morris, Kristen M S O'Connell, David C. Poole, Darleen A. Sandoval, J Carson Smith, Russell H. Swerdlow, Shawn N. Whitehead, Eric D. Vidoni, Henriette Van Praag

Faculty Research 2022

An inaugural workshop supported by "The Leo and Anne Albert Charitable Trust," was held October 4-7, 2019 in Scottsdale, Arizona, to focus on the effects of exercise on the brain and to discuss how physical activity may prevent or delay the onset of aging-related neurodegenerative conditions. The Scientific Program Committee (led by Dr. Jeff Burns) assembled translational, clinical, and basic scientists who research various aspects of the effects of exercise on the body and brain, with the overall goal of gaining a better understanding as to how to delay or prevent neurodegenerative diseases. In particular, research topics included the links …

Pdpn Marks A Subset Of Aggressive And Radiation-Resistant Glioblastoma Cells, Aram S. Modrek, Eskil Eskilsson, Ravesanker Ezhilarasan, Qianghu Wang, Lindsey D. Goodman, Yingwen Ding, Ze-Yan Zhang, Krishna P. Bhat, Thanh-Thuy T. Le, Floris P Barthel, Ming Tang, Jie Yang, Lihong Long, Joy Gumin, Frederick F. Lang, Roel G W Verhaak, Kenneth D. Aldape, Erik P. Sulman

Faculty Research 2022

Treatment-resistant glioma stem cells are thought to propagate and drive growth of malignant gliomas, but their markers and our ability to target them specifically are not well understood. We demonstrate that podoplanin (PDPN) expression is an independent prognostic marker in gliomas across multiple independent patient cohorts comprising both high- and low-grade gliomas. Knockdown of PDPN radiosensitized glioma cell lines and glioma-stem-like cells (GSCs). Clonogenic assays and xenograft experiments revealed that PDPN expression was associated with radiotherapy resistance and tumor aggressiveness. We further demonstrate that knockdown of PDPN in GSCs in vivo is sufficient to improve overall survival in an intracranial …

A-Kinase Anchor Protein 1 Deficiency Causes Mitochondrial Dysfunction In Mouse Model Of Hyperoxia Induced Acute Lung Injury., Ramani Soundararajan, Helena Hernández-Cuervo, Timothy M Stearns, Anthony J Griswold, Sahebgowda Sidramagowda Patil, Jutaro Fukumoto, Venkata Ramireddy Narala, Lakshmi Galam, Richard Lockey, Narasaiah Kolliputi

Faculty Research 2022

No abstract provided.

The Collaborative Cross Strains And Their Founders Vary Widely In Cocaine-Induced Behavioral Sensitization., Sarah A Schoenrock, Leona H. Gagnon, Ashley A Olson, Michael Leonardo, Vivek M. Philip, Hao He, Laura G. Reinholdt, S J Sukoff Rizzo, James D Jentsch, Elissa J Chesler, Lisa M Tarantino

Faculty Research 2022

Cocaine use and overdose deaths attributed to cocaine have increased significantly in the United States in the last 10 years. Despite the prevalence of cocaine use disorder (CUD) and the personal and societal problems it presents, there are currently no approved pharmaceutical treatments. The absence of treatment options is due, in part, to our lack of knowledge about the etiology of CUDs. There is ample evidence that genetics plays a role in increasing CUD risk but thus far, very few risk genes have been identified in human studies. Genetic studies in mice have been extremely useful for identifying genetic loci …

Genetic Diversity And Population Structure Of Local Sudanese Sheep Populations Revealed By Whole-Genome Sequencing, A Amane, G Belay, Abdulfatai Tijjani, T Dessie, H H. Musa, O Hanotte

Faculty Research 2022

Local Sudanese sheep populations inhabiting diverse environmental conditions and holding opposing morphologies provide opportunities for molecular-genetic research. Characterizing their genome is crucial for sustainable breeding improvement and targeting favorable genes in breeding programs. However, the genome of these sheep populations, which comprises several subtypes, remains uncharacterized using whole-genome sequence data. This study aimed to elucidate genome-wide genetic diversity and population structure of 11 local Sudanese sheep populations, namely, Hammari, Kabbashi, Meidobe, Ashgar, Dubasi, Watish, Bega, Naili, Fulani, Zagawi, and Garag. Ninety whole blood samples were collected, and we extracted DNA using a Qiagen DNeasy® extraction kit. We used the Illumina …

Witch Nails (Krt90whnl): A Spontaneous Mouse Mutation Affecting Nail Growth And Development., John P Sundberg, Hannah Galantino-Homer, Heather Fairfield, Patricia F. Ward-Bailey, Belinda S. Harris, Melissa L. Berry, C Herbert Pratt, Nicholas E Gott, Lesley S Bechtold, Pauline R Kaplan, Blythe P Durbin-Johnson, David M Rocke, Robert H Rice

Faculty Research 2022

Numerous single gene mutations identified in humans and mice result in nail deformities with many similarities between the species. A spontaneous, autosomal, recessive mutation called witch nails (whnl) is described here where the distal nail matrix and nail bed undergo degenerative changes resulting in formation of an abnormal nail plate causing mice to develop long, curved nails. This mutation arose spontaneously in a colony of MRL/MpJ-Faslpr/J at The Jackson Laboratory. Homozygous mutant mice are recognizable by 8 weeks of age by their long, curved nails. The whnl mutation, mapped on Chromosome 15, is due to a 7-bp insertion identified in …

An Integrated Approach To Studying Rare Neuromuscular Diseases Using Animal And Human Cell-Based Models., Timothy J Hines, Cathleen Lutz, Stephen A Murray, Robert W. Burgess

Faculty Research 2022

As sequencing technology improves, the identification of new disease-associated genes and new alleles of known genes is rapidly increasing our understanding of the genetic underpinnings of rare diseases, including neuromuscular diseases. However, precisely because these disorders are rare and often heterogeneous, they are difficult to study in patient populations. In parallel, our ability to engineer the genomes of model organisms, such as mice or rats, has gotten increasingly efficient through techniques such as CRISPR/Cas9 genome editing, allowing the creation of precision human disease models. Such

Psilocybin Psychotherapy With Acceptance And Commitment Therapy: A Potential Treatment For Social Anxiety Disorder, Elliot Sandberg

[Archive] Belmont University Research Symposium (BURS)

Individuals diagnosed with social anxiety disorder are in need of a more effective therapeutic intervention. Due to the nature of SAD, individuals tend to not seek care for their treatment, leading to the continuation of avoidance behaviors that significantly impact their daily existence. Psilocybin psychotherapy has the potential to lead to significant changes in the personality structure of individuals as well as reducing anxious responses to their environment in a relatively short period of time. Acceptance and commitment therapy can serve as the ideal therapeutic backing to psilocybin as it emphasizes mindfulness and psychological flexibility, both of which aid in …

Piceatannol, A Dietary Polyphenol, Alleviates Adipose Tissue Loss In Pre-Clinical Model Of Cancer-Associated Cachexia Via Lipolysis Inhibition, Jonathan Kershaw, Bennett D. Elzey, Xiao-Xuan Guo, Kee-Hong Kim

Public and Allied Health Faculty Publications

Cancer-associated cachexia (CAC) is the nutrition-independent loss of lean muscle and adipose tissues, and results in reduced chemotherapy effectiveness and increased mortality. Preventing adipose loss is considered a key target in the early stages of cachexia. Lipolysis is considered the central driver of adipose loss in CAC. We recently found that piceatannol, but not its analogue resveratrol, exhibits an inhibitory effect on lipolysis. The objective of this study was to investigate the role of piceatannol in cancer-associated lipolysis and cachexia-induced weight loss. Cancer cell-induced lipolysis in adipocytes was stimulated using cancer-conditioned media (CCM) or co-culture with human pancreatic cancer cells …

Zephyrus, Western Kentucky University

Student Creative Writing

The fine arts magazine of Western Kentucky University at Bowling Green.

Idealism And Psychoanalysis In Architecture, John Shannon Hendrix

Architecture, Art, and Historic Preservation Faculty Publications

No abstract provided.

Designing Diplomacy: Jack Masey And Multiscreen Cinema At Expo 67, Brian Real

The Journal of e-Media Studies

The United States Information Agency (USIA) was America’s international public diplomacy arm throughout the Cold War. The agency used various media to counter Soviet messaging and portray the United States in a positive light. One of the agency’s most effective means of conveying such messaging was through exhibitions, such as trade fairs and world’s fairs. Jack Masey was a skilled designer and diplomat whose experiences on the ground in India and Afghanistan in the early 1950s would shape the USIA’s approach to exhibit design and execution for decades to come. One of his most significant contributions to the agency’s success, …

Useful Experimental Cinema: Usia's Experimental Film Programming And The Film Culture In Taiwan, 1973-1979, I-Lin Liu

The Journal of e-Media Studies

This article attempts to historicize the United States Information Agency (USIA)’s programming of experimental and student films in the sixties and early seventies. Previous scholarship mainly focuses on USIA-produced films during 1962-1967; it is argued that these films demonstrated that USIA was ideologically tolerant and allowed artists to express their creativity. Complementing this viewpoint, I suggest that it is fruitful to situate USIA’s film activities within a larger media environment and understand their programming and production choices as a way to respond to controversial films put out by Hollywood and other private media producers. The second part of the article …

Nicholas J. Cull In Conversation With Hadi Gharabaghi And Bret Vukoder, Hadi Gharabagh, Bret Vukoder

The Journal of e-Media Studies

Nicholas J. Cull is a Professor of Communication and Public Diplomacy at the University of Southern California, where he founded the graduate program in Public Diplomacy.

Charles (Chas) W. Freeman In Conversation With Hadi Gharabaghi And Bret Vukoder, Hadi Gharabagh, Bret Vukoder

The Journal of e-Media Studies

Charles (Chas) W. Freeman Jr.’s career in foreign service and policy is among the most prolific and diverse.

Building Bridges To The Future: Fiscal Year 2022, Tennessee Council On Developmental Disabilities

Annual and Special Reports

This annual report highlights the accomplishments made during the fiscal year.

Dignity, Intersectional Gendered Harm, And A Flexible Approach: Analysis Of The Right To One’S Image In Quebec, Yuan Stevens

Canadian Journal of Law and Technology

This article draws on critical feminist theory and the framework of intersectionality to examine how courts in Quebec have begun — and are poised — to respond to the phenomenon of the non-consensual sharing of images, particularly if they are of an intimate or sexual nature. Dunn’s work has demonstrated that Quebec’s dignity-focused approach to the protection of identity and privacy ought to guide the development of similar civil recourse provided in common law Canada. This paper fills a gap by identifying the affordances and gaps of Quebec’s legal approach from the vantage point of equality-seeking groups, with a particular …

Nebline, January/February 2022

NEBLINE Newsletter Archive from Nebraska Extension in Lancaster County

2021 Extension Highlights

Your Trusted Educational Resource

4-H Programs Engaged 24,313 Youth

A New Year, A New You, A Renewed Community by Emily Gratopp

Garden Guide: Things to Do This Month

Extension’s 2022 Master Gardener Training, Two Sites Available

Upcoming Green Industry Conferences

ProHort Lawn & Landscape Update

2022 Pesticide Applicator Trainings

Crop Production Clinics In-Person and Zoom

Heart of 4-H Volunteer Award: Phil Wharton and Jenny DeBuhr

Watch Chicks Hatch on Egg Cam

4-H Rabbit Show, March 19

Dog Club Accepting New Members, Starts Jan. 10

4-H Club Gives Youth With Special Needs Opportunity to Show Lambs

4-H Announcements …

Ms Environmental Biology Capstone Project, Samantha Ortega

Regis University Student Publications (comprehensive collection)

This project is presented in partial fulfillment of the requirements for the degree Masters of Science in Environmental Biology at Regis University. Chapter 1 is a literature review that discusses the management implications of designing bird habitat on anthropogenic structures. Chapter 2 is a grant proposal to explore niche dominance by anthropophilic bird species in Denver, CO. Chapter 3 is a journal manuscript discussing how musth impacts captive bull Asian elephant (Elephas maximus) behavior at Denver Zoo. Finally, Chapter 4 is a stakeholder analysis for Northern Bobwhite recovery at Bridgestone-Firestone Centennial Wilderness Area, White County, Tennessee.

"We Choose To Go To The Moon": An Analysis Of A Cold War Means-Developing Strategy, David Christopher Arnold

NDU Case Studies

Strategists often ask “With the means available right now, what end can we achieve?” However, in strategy design it can be more appropriate to ask, “What is the desired end, and what means are available to achieve it?” The answer to this question may be, “If this is the desired end, first this new capability has to be created.” This case study examines how Kennedy determined he could achieve his ends (beat the Soviets in the world competition) in a particular way (shape the world conversation) using means yet to be created (the moon landing).

The Imaginal Lexicon Of Aging Studies, William Ebenstein

Publications and Research

Aging Studies focuses on the cultural, humanistic and experiential aspects of aging insofar as these are already embedded in literature, art, language and everyday life. The lexicon of this multi-disciplinary field has evolved in response to shifts in cultural attitudes, social roles, and conceptual frameworks. At the same time, many age-related words have links to poetic imagery and ancient myths, and to evocative etymologies that conjure an historical context. The article looks at the ongoing and surprisingly difficult effort to find the right word to call an older person. It reviews the language and literary genres associated with longevity. And, …

Ms Environmental Biology Capstone Project, Hannah Dekay

Regis University Student Publications (comprehensive collection)

Chapter 1: Literature Review - Human-Wildlife Conflict: Comparing Lethal and Behavioral Mitigation in Agricultural Settings

Chapter 2: Grant Proposal - Evaluating the Effectiveness and Impacts of Predator Odor Repellants for Elk Management in Colorado

Chapter 3: Journal Manuscript - Examining Post-release and Seasonal Movements in Wyoming Toads (Anaxyrus baxteri) for Current Recovery Efforts

Chapter 4: Resolving the Success of Grizzly Bear Conservation in the Greater Yellowstone and Northern Continental Divide Ecosystems: Learning to Live with Large Terrestrial Predators

Ms Environmental Biology Capstone Project, Dermot Swanson

Regis University Student Publications (comprehensive collection)

1. Atoms for Peace: Including nuclear Power as a Renewable Energy Source

2. Comparing Invasive Plant Expansion Along a Roadway Across the Elevational Gradient in the Colorado Front Range

3. Host Species has Non-uniform Effects on the Vitality of Root Hemiparasite Castilleja Species

4. Remediating Ski Industry Impacts on Montane & Alpine Plant Communities

Ms Environmental Biology Capstone Project, Chelsea Huck

Regis University Student Publications (comprehensive collection)

Chapter 1. Mitigating Human-Coyote Conflict Requires an Understanding of What Facilitates Coyote Use of Urban Spaces

Chapter 2. Investigating Attractants and Deterrents to Coyotes in The Urban Landscape

Chapter 3. Bull Asian Elephants at Denver Zoo Engage in Less Daytime and Nighttime Stereotypy When Housed Socially Compared to When Housed Alone

Chapter 4. Mitigating Wolf-Human Conflict Through Cooperation, Education, and Planning

Contributions To The Knowledge Of The Diversity Of The Chewing Lice Fauna In Turkey, Gökhan Eren, Ömral Ünsal Özkoç, Mustafa Açici

Turkish Journal of Zoology

The aim of the study was to identify the chewing lice which were sampled from the birds found dead during ornithological studies in the natural areas of Samsun, and transported to the laboratory of Ondokuz Mayıs University, Veterinary Faculty, Department of Parasitology, between 2018 and 2020. All samples were collected by ectoparasite examination. The collected lice specimens were preserved in tubes with 70% alcohol. The specimens were cleared in 10% KOH for 24 h before being mounted in Canada balsam and identified under the light microscope. A total of 35 species under 3 families were detected in this study: Menoponidae: …

Soil Resilience And Arbuscular Mycorrhizal Fungi: How Fungi Can Inform Climate Change Mitigation And Adaptation In Maya Milpa Management, Courtney Mathers

Electronic Theses and Dissertations

In Mexico’s state of Yucatán, climate change impacts like prolonged and less predictable dry season length are manifesting as threats to agricultural production and food security. Nearly two thirds of Yucatán’s population is indigenous, many of whom live in rural communities that rely on rainfed subsistence agriculture (INEGI 2015). Ensuring sufficient food production in the face of climate change relies on the quality of agricultural soils. With both mismanagement of agricultural soils and climate change posing as threats to food production in Mexico, soil management practices that increase a soil quality should be identified and promoted. The primary objective of …

Phosphatidylserine Externalization On Non-Apoptotic Cells And Lipid Scramblases In C. Elegans, Julia Frondoni

Electronic Theses and Dissertations

Cell corpse clearance is key for animals to avoid inflammation and autoimmune disease. To better understand the “eat me” signal of phosphatidylserine (PS) exposure for non-apoptotic corpse clearance, we attempted to disrupt the externalization of PS on C. elegans polar bodies. The second polar body undergoes a non-apoptotic form of cell death, loses membrane integrity, externalizes PS and is cleared by embryonic cells during early development. During apoptotic and necrotic cell death, PS asymmetry is disrupted by lipid scramblases, which translocate phospholipids between the leaflets of the lipid bilayer. We found neither apoptotic nor necrotic scramblases are required for PS …

The Visualities And Aesthetics Of Prosecuting Aged Defendants, Mark Drumbl, Caroline Fournet

Scholarly Articles

The prosecution—whether domestic or international—of international crimes and atrocities may implicate extremely aged defendants. Much has been written about the legalisms that inhere (or not) in trying these barely alive individuals. Very little however has been written about the aesthetics the barely alive encrust into the architecture of courtrooms, the optics these defendants suffuse into the trial process, and the expressive value of punishing them. This is what we seek to do in this project.

Town Of Haverhill, New Hampshire Annual Report 2021., Haverhill Town Representatives

Haverhill, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

What Is The Best Method To Cure Hiv?, Israel Hacker

The Science Journal of the Lander College of Arts and Sciences

Human Immunodeficiency Virus (HIV) is a sexually transmitted retrovirus impacting millions of people worldwide. Strides have been made to cure and/or prevent various genetic mutations via gene editing. Scientists hope to rid of HIV on a genomic level which will also prevent Acquired Immunodeficiency Syndrome (AIDS) - a biproduct of HIV. HIV utilizes a mechanism that counteracts the innate, adaptive, and intrinsic immune systems. Because the virus’s replication takes place in the lymphatic organs, the infection traverses the entire bloodstream. Due to the complexity of HIV and AIDS, their constant evolution, and their effect on a genomic level, no cures …