Digital Commons Network^™

The Tragedy Of Krudhog The Cruel: A Horrid Tale Best Never Told At All, Eric Ramos

4610 English: Individual Authors: J.R.R. Tolkien

What have I to tell you, unlucky one, of this vision brought before me? Hear it here that I, Othur Lokbrok, do not speak with a voice of my own, but rather echo the Sisters Weird, come to me one night in a passion and fury beyond all earthly resemblance. Thereupon that cursed night was I, awake and trembling, for out of a dream my spirit raised itself vigilant, as hushed voices seemed to seep and slither eerily through my window. Then in the dark at the foot of my bed a dampened candle glowed red hot as three faces, …

Ms Environmental Biology Capstone Project, Mary Strecker

Regis University Student Publications (comprehensive collection)

1. Causes of Regional Biodiversity Loss: The Case of Alpine Aquatic Macroinvertebrates

2. The Effects of Receding Glaciers on Alpine Aquatic Macroinvertebrate Diversity in Glacier National Park

3. Evaluation of Distance Sampling as a Tool for Monitoring Populations of Rare Plants (Cactaceae: Sclerocactus glaucus)

4. Protecting the Mojave Desert Tortoise and Relieving Anticipated Congestion Using an Existing Route in St. George, Utah

Reference-Free Discovery Of Nuclear Snps Permits Accurate, Sensitive Identification Of Carya (Hickory) Species And Hybrids, Robert A. Literman, Brittany M. Ott, Jun Wen, L. J. Grauke, Rachel S. Schwartz, Sara M. Handy

Biological Sciences Faculty Publications

Premise: DNA-based species identification is critical when morphological identification is restricted, but DNA-based identification pipelines typically rely on the ability to compare homologous sequence data across species. Because many clades lack robust genomic resources, we present here a bioinformatics pipeline capable of generating genome-wide single-nucleotide polymorphism (SNP) data while circumventing the need for any reference genome or annotation data. Methods: Using the SISRS bioinformatics pipeline, we generated de novo ortholog data for the genus Carya, isolating sites where genetic variation was restricted to a single Carya species (i.e., species-informative SNPs). We leveraged these SNPs to identify both full-species and hybrid …

What Machines Can Teach Us About "Confrontation", Andrea Roth

Duquesne Law Review

In this short Article, I argue that treating non-human conveyances of information-and other forms of evidence that cannot be cross-examined-as beyond the Confrontation Clause is unsatisfactory as a matter of text, history, logic, and principle. Instead, all of these clues lead to one conclusion: the right of confrontation is a right not only to physical presence of certain human witnesses to facilitate demeanor review and questioning, but to a meaningful opportunity to scrutinize the government's proof, whatever its form.⁸ That right would include out-of-court discovery of critical contextual information about the evidence, whether or not exculpatory, and a …

Estimating Road Mortality Hotspots While Accounting For Imperfect Detection: A Case Study With Amphibians And Reptiles, Noah Hallisey, Scott W. Buchanan, Brian Gerber, Liam S. Corcoran, Nancy E. Karraker

Natural Resources Science Faculty Publications

Wildlife road mortality tends to aggregate spatially at locations commonly referred to as road mortality hotspots. Predictive models can be used to identify locations appropriate for mitigation measures that reduce road mortality. However, the influence of imperfect detection (e.g., false absences) during road mortality surveys can lead to inaccurate or imprecise spatial patterns of road mortality hotspots and suboptimal implementation of mitigation measures. In this research, we used amphibians and reptiles as a case study to address imperfect detection issues when estimating the probability of road mortality hotspots using occupancy detection modeling. In addition, we determined the survey effort needed …

Rethinking Habitat Occupancy Modeling And The Role Of Diel Activity In An Anthropogenic World, Kimberly Rivera, Mason Fidino, Zach J. Farris, Seth B. Magle, Asia Murphy, Brian Gerber

Natural Resources Science Faculty Publications

Current methods to model species habitat use through space and diel time are limited. Development of such models is critical when considering rapidly changing habitats where species are forced to adapt to anthropogenic change, often by shifting their diel activity across space. We use an occupancy modeling framework to specify the multistate diel occupancy model (MSDOM), which can evaluate species diel activity against continuous response variables that may impact diel activity within and across seasons or years. We used two case studies, fosas in Madagascar and coyotes in Chicago, Illinois, to conceptualize the application of this model and to quantify …

Teaching A Hybrid Administrative Law Simulation Class Using Jurassic Park, Roberto L. Corrada

Sturm College of Law: Faculty Scholarship

For more than a decade, educators and scholars have been calling for changes in methods of instruction, especially in higher education, based on developments in the field of learning science. This has been true for legal education as well, but additionally based on fundamental shifts in the way legal employers, especially law firms, hire and train new lawyers? These suggested changes for legal education include more emphasis on professional skills training, leadership development, and teamwork. While there has been no dearth of writing about the need for change in legal education, and even about specific outcomes or goals for legal …

Comparison Of Effects Of Sleep Fragmentation On Pro-Inflammatory Cytokine Il-1Β Of Male And Female Adult Mice, Manzar Rzayeva

Mahurin Honors College Capstone Experience/Thesis Projects

Sleep plays an essential role throughout the body by affecting the physiological function and regulation of many systems. One of these systems that receives effects as a result of the adequacy of sleep is the immune system. Previous studies have demonstrated effects of sleep fragmentation upon the immune system; however, sexual differences of these effects have not been studied in depth. To analyze these variances amongst the genders, male and female adult mice were subjected to acute sleep fragmentation (SF) for 24 hours in an automated SF cage that includes a bar sweeping across the cage every two minutes. Meanwhile, …

Crossmodal Perception Of Object Shape: A Study On The Effect Of Modal Order On Successful Shape Recognition, Ashlyn Vale

Mahurin Honors College Capstone Experience/Thesis Projects

Visual and haptic (tactile) modes of perception, while occasionally exercised independently, most often occur concurrently. The degree to which the ordering of the two modes of perception affects successful recognition of three-dimensional shapes varies. Some have found that the cross-modal orders (vision followed by haptics or vice versa) produce equal performance (Caviness, 1964; Lacey, Peters, & Sathian, 2007; Norman et al., 2006), while other researchers found visual-haptic (VH) performance to be superior to haptic-visual (HV) performance (Davidson, Abbott, & Gershenfeld, 1974; Norman, Clayton, Norman, & Crabtree, 2008). The current experiment used an old-new recognition task (with cookie cutter stimuli). In …

Kids, Culture, And Queerness: The Progression Of Lgbtq+ Representation In Children's Media, Sarah Stevens

Mahurin Honors College Capstone Experience/Thesis Projects

Historically, popular media has functioned as a window into society’s ever evolving idea of normalcy. Children’s popular media, which contains elements of both entertainment and didacticism, is further burdened with the responsibility of influencing the perspectives of upcoming generations. This truth is particularly salient for the LGBTQ+ community, who have faced consistent misrepresentation or utter erasure from children’s media in the recent past. While there have been marked improvements in both the quality and quantity of queer representation in children’s media since 2015’s Obergefell v. Hodges case, there is still a significant need to acknowledge intersectional queerness and queer gender …

Three Waves: The United States Opioid Crisis, Ryan B. Santoro

Senior Scholars Papers in Science, Technology, and Society

The past two and a half decades have witnessed widespread suffering, addiction, and death at the hands of the opioid crisis. This paper analyzes the crisis through a series of time periods, broken down into “waves.” Drawing upon primary material in relation to OxyContin advertisements in the 1990’s, this research takes aim at the origin of widespread opioid abuse disorder. By building upon analysis done on the Sackler Family, Purdue Pharma, heroin abuse, fentanyl overdoses, the COVID-19 pandemic and opioids and addiction in modern pop culture, this thesis shows how despite constant change in public policy, the opioid crisis continues …

What Is "Speedrunning?" Industry, Community, Identity, Riley Scott Kelfer

Senior Scholar Papers

What drives interaction in online contexts? How do “internet communities” form, and how do they generate a sense of interpersonal closeness? I address such questions through a cultural analysis of video game “speedrunning,” an emergent online community that some commentators have noted for its remarkable commitment to compassion and mutual advancement. While several game scholars have explored the narrative and temporal implications of the live-streamed and recorded speedrun, few have directed their attention to the ways in which video game speedrunning, as a community of dedicated practitioners and spectators, is informed by historical precedents and contemporary social processes. I place …

Soil Project, Gabriella Hopkins

Natural Sciences Student Research Presentations

What are soil-borne diseases?

- Soil-borne diseases are diseases that can infect plants, animals, and human via soil.

- There are multiple different pathogens that contaminate soil and cause disease including bacteria, fungi, and helminths (parasitic worms). Most of these lay dormant (inactive) in the soil until they come in contact with a host.

- A host such as an animal can become infected by inhaling dormant spores or eggs in the case of helminths or by the pathogen coming in contact with an open wound. These situations are also the case for humans, but humans can also become infected …

Soil Health And The Effects Of Nanoparticles, Elijah Mock

Natural Sciences Student Research Presentations

I researched the effects of soil on human health. Specifically, I was interested in nanoparticles that reside in soil and how they affect humans as well as crops that are planted in the soil. This topic is relevant because nanoparticles can be used to deliver drugs for doctors, create specific properties for material scientists, sensors for the military, and in a plethora of other fields (“What Are Nanoparticles? Definition, Size, Uses and Properties.”).

Harpur Palate Volume 21, Issue 2, .

Harpur Palate: a Literary Journal

Haolun Xu | Carl Boon | Dylan Brown | Cynthia Dockrell | Piper Gourley | Savannah Harris | Allen M. Price | Angela Miyuki Mackintosh | Savannah Harris | Mark L. Keats | Jennifer Perrine | Anika Somaia | Melissa Webster | Katherine Gaffney | Donna Vorreyer | Katrina Agbayani | Dan Albergotti | Craig Beaven | Sera Gamble | Steve Henn | Maria Hiers | Elizabeth Hoover | Paul Ilechko | Ted Jean | Andie Klarin | Ashley Seitz Kramer | Ashley Seitz Kramer | Helena Olufsen | Matthew Roth

Vii. Learning Totaste: Praising The Transcendent Rilke’S Sonnets To Orpheus Heidegger Hölderlin Heraclitus, Charles S. Taylor

Wine Journey: Tasting Dwelling Learning at The Kitchen Table

Oh 2005 R. Lopez de Heredia Viña Tondonia Bianco Reserva!

It was to accompany pan-seared sea scallops in a vinagreta of grape seed oil, vinagre de Jerez, chervil, chives and parsley from our garden. The previous bottle had been the best pairing to date. But, the taste of the wine became everything. This fifth and last 2005 from my cellar was unique, similar to neither any of its siblings nor to any other wine. It was expected to be close to one a year earlier. R. Lopez de Heredia wines are not released until ready for drinking; this one had …

Worcester Public Art For Esl Students, Eleanor Rueffer

Visual and Performing Arts

Funded by the Steinbrecher Fellowship, "Worcester Public Art for ESL Students" are original teaching materials (a 28-page booklet and worksheets) that utilize simple English to introduce some of Worcester's iconic public artworks. While the intended audience is English learners, the focus is on the content and is encouraged for use by anyone looking to enjoy and learn about Worcester history and art.

The booklet includes descriptions and histories of six Worcester artworks (Burnside Fountain, Soldiers' Monument, Major Taylor Statue, Mechanics Hall Mural, Rogers-Kennedy Memorial, and Chamberlain Fountain) with technical terms or difficult words bolded and explained in a glossary.

Eleanor …

The Bridge, Volume 19, 2022, Bridgewater State University

the bridge

Managing Editor:

Grace Guindon

Editors:

Dakota Lopes

Jonathon Gillis

Stephanie Pizella

Meghan Joyce

Design Lead:

Cay Berman

Designers:

Lucy Flaherty

Jessica Hayes

Bao Huynh

Michael Seguer

Faculty Advisor:

Dr. Carrie Oeding

Design Advisor:

Professor Alain Blunt

Art/Work: Labor, Identity, And Society, Zirui Feng, Elinor G. Gass, Ran Li, Lauren C. Mcveigh, Matthew S. Montes, Lin Zhu, Yan Sun

Schmucker Art Catalogs

Artists, perhaps to emphasize their own dedication to the intellectual and manual skills required for making art, have long been drawn to the theme of labor, both in their depictions of workers and scenes of making. In the late seventeenth century, Dutch paintings frequently portrayed earnest and diligent artisans performing trades at shops or on the streets. Later, rapid economic, social and political changes throughout Europe in the mid-nineteenth century led to a more radical approach to realist representations of labor. This exhibition ART/WORK: Labor, Identity, and Society considers these art-historical precedents to explore the issues of labor in art. …

Empowering Students Toward Empathy, Awareness, And Respect Through The Discussion Of High Quality Children’S Literature, Jesse Blumberg

Graduate Student Independent Studies

This paper explores the importance of utilizing high quality books with elementary-aged students to encourage their ability to recognize, appreciate, and celebrate similarities and differences in our society.

2002 - 2022 Senior Thesis Projects, Honors College

2002-2022 Senior Thesis Projects Index

This is a compilation of the Senior Thesis projects completed from 2002 through 2022 in the Honors College, formerly known as the University Honors Program. The contents include thesis projects by year of student graduation, an index by major, an index by mentor, and an alphabetical index by student author.

Icipe Annual Report 2022, International Centre Of Insect Physiology And Ecology (Icipe)

icipe Annual Reports

No abstract provided.

Updated Perspectives On The Role Of Biomechanics In Copd: Considerations For The Clinician, Jennifer M. Yentes, Wai-Yan Liu, Kuan Zhang, Eric Markvicka, Stephen I. Rennard

Journal Articles: Pulmonary & Critical Care Med

Patients with chronic obstructive pulmonary disease (COPD) demonstrate extra-pulmonary functional decline such as an increased prevalence of falls. Biomechanics offers insight into functional decline by examining mechanics of abnormal movement patterns. This review discusses biomechanics of functional outcomes, muscle mechanics, and breathing mechanics in patients with COPD as well as future directions and clinical perspectives. Patients with COPD demonstrate changes in their postural sway during quiet standing compared to controls, and these deficits are exacerbated when sensory information (eg, eyes closed) is manipulated. If standing balance is disrupted with a perturbation, patients with COPD are slower to return to baseline …

An Artifact In Intracellular Cytokine Staining For Studying T Cell Responses And Its Alleviation., Zheng Gong, Qing Li, Jiayuan Shi, Guangwen Ren

Faculty Research 2022

Intracellular cytokine staining (ICS) is a widely employed ex vivo method for quantitative determination of the activation status of immune cells, most often applied to T cells. ICS test samples are commonly prepared from animal or human tissues as unpurified cell mixtures, and cell-specific cytokine signals are subsequently discriminated by gating strategies using flow cytometry. Here, we show that when ICS samples contain Ly6G⁺ neutrophils, neutrophils are ex vivo activated by an ICS reagent - phorbol myristate acetate (PMA) - which leads to hydrogen peroxide (H₂O₂) release and death of cytokine-expressing T cells. This artifact …

Independent Dsg4 Frameshift Variants In Cats With Hair Shaft Dystrophy., Sarah Kiener, Ana Rostaher, Silvia Rüfenacht, Vidhya Jagannathan, John P Sundberg, Monika Welle, Tosso Leeb

Faculty Research 2022

Investigations of hereditary phenotypes in spontaneous mutants may help to better understand the physiological functions of the altered genes. We investigated two unrelated domestic shorthair cats with bulbous swellings of the hair shafts. The clinical, histopathological, and ultrastructural features were similar to those in mice with lanceolate hair phenotype caused by loss-of-function variants in Dsg4 encoding desmoglein 4. We sequenced the genomes from both affected cats and compared the data of each affected cat to 61 control genomes. A search for private homozygous variants in the DSG4 candidate gene revealed independent frameshift variants in each case, c.76del or p.Ile26fsLeu*4 in …

Identification Of Quantitative Trait Loci For Survival In The Mutant Dynactin P150glued Mouse Model Of Motor Neuron Disease., Guillermo M Alexander, Terry D Heiman-Patterson, Frank Bearoff, Roger B Sher, Laura Hennessy, Shannon Terek, Nicole Caccavo, Gregory A Cox, Vivek M. Philip, Elizabeth A Blankenhorn

Faculty Research 2022

Amyotrophic lateral sclerosis (ALS) is the most common degenerative motor neuron disorder. Although most cases of ALS are sporadic, 5-10% of cases are familial, with mutations associated with over 40 genes. There is variation of ALS symptoms within families carrying the same mutation; the disease may develop in one sibling and not in another despite the presence of the mutation in both. Although the cause of this phenotypic variation is unknown, it is likely related to genetic modifiers of disease expression. The identification of ALS causing genes has led to the development of transgenic mouse models of motor neuron disease. …

The Th1/Tfh-Like Biased Responses Elicited By The Rasp-1 Innate Adjuvant Are Dependent On Trif And Type I Ifn Receptor Pathways., Parakkal Jovvian George, Radu Marches, Djamel Nehar-Belaid, Jacques Banchereau, Sara Lustigman

Faculty Research 2022

No abstract provided.

Targeting Sars-Cov-2 Infection Through Car-T-Like Bispecific T Cell Engagers Incorporating Ace2., Mikail Dogan, Lina Kozhaya, Lindsey Placek, Fatih Karabacak, Mesut Yigit, Derya Unutmaz

Faculty Research 2022

OBJECTIVES: Despite advances in antibody treatments and vaccines, COVID-19 caused by SARS-CoV-2 infection remains a major health problem resulting in excessive morbidity and mortality and the emergence of new variants has reduced the effectiveness of current vaccines.

METHODS: Here, as a proof-of-concept, we engineered primary CD8 T cells to express SARS-CoV-2 Spike protein-specific CARs, using the extracellular region of ACE2 and demonstrated their highly specific and potent cytotoxicity towards Spike-expressing target cells. To improve on this concept as a potential therapeutic, we developed a bispecific T cell engager combining ACE2 with an anti-CD3 scFv (ACE2-Bite) to target infected cells and …

Intergenomic And Epistatic Interactions Control Free Radical Mediated Pancreatic Β-Cell Damage., Jing Chen, Renhua Li, Sarah Knapp, Guizhi Zhu, Robert L Whitener, Edward H. Leiter, Clayton E Mathews

Faculty Research 2022

Alloxan (AL)-generated Reactive Oxygen Species (ROS) selectively destroy insulin-producing pancreatic β-cells. A previous genome-wide scan (GWS) using a cohort of 296 F2 hybrids between NOD (AL-sensitive) and ALR (AL-resistant) mice identified linkages contributing to β-cell susceptibility or resistance to AL-induced diabetes on Chromosomes (Chr) 2, 3, 8, and a single nucleotide polymorphism in

Engineering A "Detect And Destroy" Skin Probiotic To Combat Methicillin-Resistant Staphylococcus Aureus., Changhui Guan, Peter J Larson, Elizabeth Fleming, Alexander P Tikhonov, Sara Mootien, Trudy H Grossman, Caroline Golino, Julia Oh

Faculty Research 2022

The prevalence and virulence of pathogens such as methicillin-resistant Staphylococcus (S.) aureus (MRSA), which can cause recurrent skin infections, are of significant clinical concern. Prolonged antibiotic exposure to treat or decolonize S. aureus contributes to development of antibiotic resistance, as well as depletion of the microbiome, and its numerous beneficial functions. We hypothesized an engineered skin probiotic with the ability to selectively deliver antimicrobials only in the presence of the target organism could provide local bioremediation of pathogen colonization. We constructed a biosensing S. epidermidis capable of detecting the presence of S. aureus quorum sensing autoinducer peptide and producing lysostaphin …