Digital Commons Network^™

Can Stem Cell Transplantation Restore Insulin Levels In Diabetics?, Nechama Mendelson

The Science Journal of the Lander College of Arts and Sciences

A recent public interest in stem cell research has led to new approaches to treat various pathologies, including diabetes. Diabetes mellitus is characterized by elevated blood glucose levels due to the inability of the β cells in the pancreas to produce insulin. Therefore, the standard diabetes treatment is introducing insulin to the bloodstream. With the advancement of stem cell therapy, a new approach to treating diabetes mellitus is being researched. Scientists are working to differentiate pluripotent stem cells into mature insulin-producing pancreatic beta cells. These cells are then transplanted into in vivo models and observed after a glucose challenge for …

Fifth Grade Sample Lessons, Elizabeth Martinez

K-5 Integrating ELA and Science

No abstract provided.

Emerging Biomedical Applications Of The Vesicular Stomatitis Virus Glycoprotein, Sheeba Rehman, Suman Bishnoi, Rajarshi Roy, Anshu Kumari, Harikrishnan Jayakumar, Sharad Gupta, Parimal Kar, Asit K. Pattnaik, Bebasis Nayak

School of Veterinary and Biomedical Sciences: Faculty Publications

Nanoparticles (NPs) made of metals, polymers, micelles, and liposomes are increasingly being used in various biomedical applications. However, most of these NPs are hazardous for long- and short-term use and hence have restricted biomedical applications. Therefore, naturally derived, biocompatible, and biodegradable nanoconstructs are being explored for such applications. Inspired by the biology of viruses, researchers are exploring the viral proteins that hold considerable promise in biomedical applications. The viral proteins are highly stable and further amenable to suit specific biological applications. Among various viral proteins, vesicular stomatitis virus glycoprotein (VSV-G) has emerged as one of the most versatile platforms for …

Phip-Seq Reveals Autoantibodies For Ubiquitously Expressed Antigens In Viral Myocarditis, Mahima T. Rasquinha, Ninaad Lasrado, Erika M. Petro-Turnquist, Eric A. Weaver, Thiagarajan Venkataraman, Daniel R. Anderson, H. Benjamin Larman, Jay Reddy

School of Veterinary and Biomedical Sciences: Faculty Publications

Simple Summary: Myocarditis is the inflammation of the heart muscle, and viral infections are a common cause of this disease. Myocarditis in some patients can progress to dilated cardiomyopathy (DCM). The mouse model of coxsackievirus B3 (CVB3) is commonly used to understand this disease progression in DCM patients. In this paper, we have attempted to analyze antibodies for heart antigens that could be produced as a result of heart damage in animals infected with CVB3 using a technique called Phage ImmunoPrecipitation Sequencing (PhIP-Seq). The analyses led us to identify antibodies for several proteins that were not previously reported that may …

The Applications And Challenges Of The Development Of In Vitro Tumor Microenvironment Chips, Annika Johnson, Samuel Reimer, Ryan Childres, Grace Cupp, Tia C L Kohs, Owen J T Mccarty, Youngbok (Abraham) Kang

Faculty Publications - Biomedical, Mechanical, and Civil Engineering

The tumor microenvironment (TME) plays a critical, yet mechanistically elusive role in tumor development and progression, as well as drug resistance. To better understand the pathophysiology of the complex TME, a reductionist approach has been employed to create in vitro microfluidic models called “tumor chips”. Herein, we review the fabrication processes, applications, and limitations of the tumor chips currently under development for use in cancer research. Tumor chips afford capabilities for real-time observation, precise control of microenvironment factors (e.g. stromal and cellular components), and application of physiologically relevant fluid shear stresses and perturbations. Applications for tumor chips include drug screening …

Ms Environmental Biology Capstone Project, Catherine Shapiro

Regis University Student Publications (comprehensive collection)

Chapter 1: Artificial light at night disrupts the biology of fishes. Chapter 2: Grant proposal to determine how artificial light at night affects Pumpkinseed fish. Chapter 3: Management of pinyon-juniper woodland impacts the occupancy of Pinyon Jays. Chapter 4: Stakeholder analysis of horseshoe crab fishing and its impacts on the Red Knot and biomedical industry.

Doodling As Self-Expression: Building Self-Efficacy In Normally Functioning Adults, Journey Coward

Art Therapy | Theses and Dissertations

While previous studies identify doodling as a useful educational tool, this study sought to determine if doodling can build creative or emotional self-efficacy. Self-efficacy is an individual’s belief in their own capacity to express behaviors necessary to attain specific performance goals. The current study also sought to determine if doodling can be a form of self-care. Research collected was quantitative and qualitative using surveys to measure both creative and emotional self-efficacy along with a doodling activity. Ten participants were recruited through convenience sampling on social media and were included in the study after meeting the inclusion criteria of identifying themselves …

Pediatric Cardiac Devices: Recent Progress And Remaining Problems, Kyle Crawford, Martine Leberge, Dan Simionescu, Naren Vyavahare

Publications

Pediatric cardiology is a field that largely relies on translation of innovation in its adult counterpart in order to improve patient outcomes and introduce new technology to the field. Few FDA-approved pediatric cardiac devices are available for clinical use, thus leading to widespread off-label use within the field. Nonetheless, adaption of devices and technology from the adult field has proven to improve patient outcomes and overall wellness. However, the diversity of congenital heart disease, in terms of basic anatomy and treatment response, continues to complicate results. The combination of diversity of anatomy and small population size make it difficult for …

A Phytobacterial Tir Domain Effector Manipulates Nad+ To Promote Virulence, Samuel Eastman, Thomas Smith, Mark A. Zaydman, Panya Kim, Samuel Martinez, Neha Damaraju, Aaron Diantonio, Jeffrey Milbrandt, Thomas Clemente, James R. Alfano, Ming Guo

Department of Agronomy and Horticulture: Faculty Publications

The Pseudomonas syringae DC3000 type III effector HopAM1 suppresses plant immunity and contains a Toll/interleukin-1 receptor (TIR) domain homologous to immunity-related TIR domains of plant nucleotide-binding leucine-rich repeat receptors that hydrolyze nicotinamide adenine dinucleotide (NAD+) and activate immunity. In vitro and in vivo assays were conducted to determine if HopAM1 hydrolyzes NAD+ and if the activity is essential for HopAM1’s suppression of plant immunity and contribution to virulence. HPLC and LC-MS were utilized to analyze metabolites produced from NAD+ by HopAM1 in vitro and in both yeast and plants. Agrobacterium-mediated transient expression and in planta inoculation assays were performed to …

Leptospiral Proteins As Potential Immunity Targets To Protect Individuals Against Reinfection, Yicong Liu

Public Health Theses

Leptospirosis is a disease caused by pathogenic species of spirochetes of the genus Leptospira. The bacteria are widespread globally and can survive in the environment for weeks after being excreted through the urine of infected animals. Humans get infected through contact with contaminated water or soil. Leptospirosis is a life-threatening disease with a wide range of symptoms. It is believed that after infection, individuals acquire natural immunity against the same infecting serovar. However, there are over 300 serovars of Leptospira that can cause disease in humans and animals, and reinfections are common. Nevertheless, recent studies have shown that reinfection caused …

2021-2022: Geek Out!, St. Norbert College

2021-2022

Nerd culture is mainstream. Comic books, board games, sci-fi, superheroes and video games are all central parts of our current moment in popular culture. Even during times of great division, nerd culture has the power to bring people together. It's also a critical site for thinking about issues of identity and power. During #YearGeekOut, the Cassandra Voss Center brought powerful artists, scholars and change-makers for a year-long deep dive into all things nerddom. Let's #GeekOut! 👾🤓

Altered Gene Expression In Response To Chronic Cardiac Sarcomere Modifications, Oula Salih, Emily Lavey, Margaret Westfall

Summer Research

No abstract provided.

Antiracist Lawyering In Practice Begins With The Practice Of Teaching And Learning Antiracism In Law School, Danielle M. Conway

Faculty Scholarly Works

I was honored by the invitation to deliver the 2021 Lee E. Teitelbaum keynote address. Dean Teitelbaum was a gentleman and a titan for justice. I am confident the antiracism work ongoing at the S.J. Quinney College of Law would have deeply resonated with him, especially knowing the challenges we are currently facing within and outside of legal education, the legal academy, and the legal profession. I am fortified in this work by Dean Elizabeth Kronk Warner’s commitment to antiracism and associated diversity, equity, and inclusion work. Finally, I applaud the students who serve on the Utah Law Review for …

Voices Of Usu: An Anthology Of Student Writing, Vol. 15, Utah State University Department Of English

Voices of USU

This collection of student writing represents the voices of over 2,000 students who enroll each academic year in Utah State University’s second-year composition course, Intermediate Writing: Research Writing in a Persuasive Mode. Voices of USU celebrates excellence in writing by providing undergraduate students of diverse backgrounds and disciplines the opportunity to have their work published.

Sea Turtle Conservation Program - 2022 Report, Derek Burkholder, Abby Nease

Sea Turtle Nesting Trends Technical Reports

No abstract provided.

Yale School Of Medicine Facts & Figures 2022-2023, Yale School Of Medicine Office Of Communications

Facts & Figures – annual Yale School of Medicine numbers

Provided by the Office of Communications, the Facts and Figures brochure is produced annually as a way to provide a snapshot of key facts and data related to the School of Medicine as well as the Medical Campus. This includes enrollment data, research activity, financial summaries, and more.

How Might We Help Jwu Eco Center Educate, Engage, And Raise Awareness About Their Programs On Instagram?, Lauren Hoetger, Casey Kowalczyk, Amanda Ladino, Abby Nickerson

Outstanding Student Scholarship

No abstract provided.

“Subverting” The Neoclassic Constraints: The Presence Of Magic In Early Commedia Dell’Arte, Yangzhou Bian

Theatre Student Scholarship

The project is an initiating discussion about the dramatic function and social-ideological implication of magic and magical elements in the surviving corpus of the Italian improvisational theater commedia dell’arte scenarios from the early seventeenth century. The essay begins with a cursory exploration of the position of commedia dell'arte amongst other notable theatrical forms blossoming across the European continent in the late renaissance. The study then focuses on eight plays selected from the 1611 Scala Collection to further examine the use of magic by commedia performers, followed by individual analysis of plot construct and dramaturgical theories. Finally, observations and connections made …

Modulation Of Human Gut Microbiota Through Dietary Associations, Sumudu Sasanka Rajakaruna

Browse all Theses and Dissertations

Study of human gut microbiota is becoming widely popular in recent years, especially due to numerous beneficial aspects attributed to this diverse and complex microbial communities. Followingly, there is a keen interest in understanding the dynamics and subsequent modulation of human gut microbiota, from a health perspective. Diet is considered significant in shaping gut microbiota community and functions, predominantly due to dietary macro and micronutrient content. Subsequently, a plethora of research is carried out on the effects of dietary nutrients on gut microbiota. Dietary patterns, quality of the diet, differences in food preparation methods, physiological and chemical changes occurred during …

Virtual Reality-Based Serious Role-Playing Games As Digital Experiential Learning Tools To Deliver Healthcare Skills Through Mobile Devices, Dixit Bharatkumar Patel

Browse all Theses and Dissertations

Inadequate professional training and practices related to health care may result in severe complications to care experiences and outcomes. Moreover, healthcare professionals are as susceptible to the possibility of implicit biases as any other group. Importantly, the health care training is critical and challenging as minor prejudicial beliefs have an adverse influence or serious consequences on patients' health outcomes. Thus, facilitating serious role-playing virtual care practices along with raising awareness of healthcare professionals about the enduring impact of implicit/explicit biases and Social Determinants of Health (SDH) on health outcomes assist to advance the patient-provider relation, care experiences (e.g., healthcare experience …

Anna Is Adopted!, Annagrace Johnson

Department of Educational Curriculum and Instruction

"Anna is Adopted" is a realistic fiction short story with actual scenarios from my childhood growing up. The purpose of this story is to bring awareness to the feelings of misplacement for all children. Based on personal experience, adoption is not recognized in a positive light each day at school no matter how parents manage the issues. This story is written for younger elementary age students but can be applied to students of all ages. Since the story is based on rich lived experience, it is a great resource for children, parents, and teachers to address problems such as anxiety, …

What’S Hiding In The Spine? A Study Of Adhesives In Medieval Books Using Mass Spectrometry, Alice Hutton Sharp, Sarah Fiddyment, Anne Lama, Jessica Lockhart, Deborah Meert-Williston, Melissa Moreton, Lauren Williams, Alexandra Gillespie

Western Libraries Publications

Glues, and in particular glued spines, are notable features of late medieval European books, yet little research has been done into how they were sourced, produced, and used. In this article we present preliminary results from using the paleoproteomic methods of Electromagnetic Zooarchaeology through Mass Spectrometry (eZooMS) and Peptide Mass Fingerprinting (PMF) to identify the source species for animal glues used in late medieval books. We first introduce readers to the principal kinds of glue used in medieval craftsmanship and what is known about their use in bookbinding, principally from the discipline of book conservation. We describe the micro-sampling methods …

A Radiofrequency Coil To Facilitate Task-Based Fmri Of Awake Marmosets, Kyle Gilbert, Audrey Dureux, Azadeh Jafari, Alessandro Zanini, Peter Zeman, Ravi S. Menon, Stefan Everling

Robarts Imaging Publications

Background: The small common marmoset (Callithrix jacchus) is an ideal nonhuman primate for awake fMRI in ultra-high field small animal MRI scanners. However, it can often be challenging in task-based fMRI experiments to provide a robust stimulus within the MRI environment while using hardware (an RF coil and restraint system) that is compatible with awake imaging. New Method: Here we present an RF coil and restraint system that permits unimpeded access to an awake marmoset’s head subsequent to immobilization, thereby permitting the setup of peripheral devices and stimuli proximal to the head.

Results: As an example application, an …

Towards Ultrasound-Based Navigation: Deep Learning Based Ivc Lumen Segmentation From Intracardiac Echocardiography, Hareem Nisar, Patrick Carnahan, Djalal Fakim, Humayoun Akhunzada, David Hocking, Elvis Chen, Terry Peters

Robarts Imaging Publications

ascular navigation is a prerequisite to transcatheter cardiac interventions. The current standard approach to catheter navigation relies on real-time fluoroscopy, while this technique utilizes ionizing radiation and it places the interventionalist at risk for eye cataracts and cancer. The shielding equipment needed to mitigate these risks is associated with spinal issues and neck and back pain which has led towards the coining of the term "interventionalist's disc disease". A proposed alternative is to have an ultrasound-guided vascular navigation system where a catheter-based ultrasound probe scans the vessel and reconstructs the vascular roadmap, which can then be navigated by tracked guidewire …

The Unfolded Protein Response: An Emerging Therapeutic Target For Pancreatitis And Pancreatic Ductal Adenocarcinoma, M. Teresa Borrello, Mickenzie B. Martin, Christopher L. Pin

Paediatrics Publications

Pancreatitis is a debilitating disease involving inflammation and fibrosis of the exocrine pancreas. Recurrent or chronic forms of pancreatitis are a significant risk factor for pancreatic ductal adenocarcinoma. While genetic factors have been identified for both pathologies, environmental stresses play a large role in their etiology. All cells have adapted mechanisms to handle acute environmental stress that alters energy demands. A common pathway involved in the stress response involves endoplasmic reticulum stress and the unfolded protein response (UPR). While rapidly activated by many external stressors, in the pancreas the UPR plays a fundamental biological role, likely due to the high …

Social Factors And The Neurobiology Of Pathogen Avoidance, Martin Kavaliers, Klaus Peter Ossenkopp, Cashmeira Dove Tyson, Indra R. Bishnoi, Elena Choleris

Neuroscience Institute Publications

Although the evolutionary causes and consequences of pathogen avoidance have been gaining increasing interest, there has been less attention paid to the proximate neurobiological mechanisms. Animals gauge the infection status of conspecifics and the threat they represent on the basis of various sensory and social cues. Here, we consider the neurobiology of pathogen detection and avoidance from a cognitive, motivational and affective state (disgust) perspective, focusing on the mechanisms associated with activating and directing parasite/pathogen avoidance. Drawing upon studies with laboratory rodents, we briefly discuss aspects of (i) olfactory-mediated recognition and avoidance of infected conspecifics; (ii) relationships between pathogen avoidance …

Fsu Law Focus - 09/28/2022, Fsu College Of Law Office Of Communications

FSU Law Focus Newsletter

From the Dean: Animal Law Writing Competition winners; Peer Elevation Program Launches; Alum Profile: Brad deBeaubien ('08); Student Profile: Grace Speas

Fsu Law Focus - 10/21/2022, Fsu College Of Law Office Of Communications

FSU Law Focus Newsletter

From the Dean: Stoops Law Center of Law & Business executive education courses; Fall 2022 Distinguished Environmental Lecture; Alum Profile: Richard D. Rivera (’13); Student Profile: 3L Caroline Dike

Endangered Languages: A Sketch Of The Sengwer Sound System, Jamas Nandako

Journal of the Language Association of Eastern Africa

Within the next century as many as half of the world’s seven thousand languages, are poised to become extinct at an alarmingly accelerated rate (Evans 2010). This correlates to a loss of knowledge, collective and individual identities, and social values. This loss is not only one of the most serious issues facing humanity today, but also it is representative of an unspeakable loss of information invaluable to humanity. This is so because these languages are among our few sources of evidence for understanding human history and each of these languages embodies unique local knowledge of the cultures and natural systems …

A Reality Not Of This World, Samantha Katlyn Herbst

Philomathean

No abstract provided.