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Full-Text Articles in Entire DC Network
Book Review: Are Perpetrators Under-Researched?, Christian Gudehus
Book Review: Are Perpetrators Under-Researched?, Christian Gudehus
Genocide Studies and Prevention: An International Journal
No abstract provided.
Information Seeking Behavior On Youtube's Recommendation System For Undergraduate Students In Surabaya Indonesia, Youngjoon Yang, Edi Dwi Riyanto, Imam Yuadi
Information Seeking Behavior On Youtube's Recommendation System For Undergraduate Students In Surabaya Indonesia, Youngjoon Yang, Edi Dwi Riyanto, Imam Yuadi
Library Philosophy and Practice (e-journal)
YouTube is the most used social media platform in the world where users search for information through various search tools provided. This study aims to analyze the behavior of information-seeking on YouTube among undergraduate students in Surabaya, Indonesia. We examined their information-seeking behavior and its implementation in daily life. We also evaluated the information needs and interests. This research conducted online questionnaires that were sent to undergraduate students from 27 August 2021 to 6 September 2021 and received 143 responses. We then analyzed the data based on the response results and statistics from Google Forms. The results showed that they …
Substrate Delivery Of Embedded Liposomes, Srivatsan Kidambi, Stephen L. Hayward
Substrate Delivery Of Embedded Liposomes, Srivatsan Kidambi, Stephen L. Hayward
Department of Chemical and Biomolecular Engineering: Faculty Publications
This invention relates to compositions useful for localized and sustained release of therapeutic agents , and more par ticularly to functionalized liposomes embedded in a poly electrolyte multilayer . Methods of preparing the composi tions , methods of treating diseases , devices , and pharmaceutical compositions comprising the compositions are also provided
Substrate Delivery Of Embedded Liposomes, Srivatsan Kidambi, Stephen L. Hayward
Substrate Delivery Of Embedded Liposomes, Srivatsan Kidambi, Stephen L. Hayward
Department of Chemical and Biomolecular Engineering: Faculty Publications
This invention relates to compositions useful for localized and sustained release of therapeutic agents, and more particularly to functionalized liposomes embedded in a poly electrolyte multilayer. Methods of preparing the compositions, methods of treating diseases, devices, and pharmaceutical compositions comprising the compositions are also provided.
Muscle Assessment System And Method, Steven M. Barlow, Jacob L. Greenwood
Muscle Assessment System And Method, Steven M. Barlow, Jacob L. Greenwood
Department of Special Education and Communication Disorders: Faculty Publications
A system and method are described for assessing muscle parameters (e.g., force(s) exerted, force dynamics, strength, voluntary muscle movement, etc.) in a diagnostic or therapeutic environment. The muscle parameter assessment system includes a force-gauging device and a computing device. The force-gauging device includes at least one pressure-sensing component (e.g., transducer, pressure sensor, etc.) configured to respond to a force applied by a subject and produce one or more output signals. The force gauging device can further include electronic circuitry con figured to convert the output signals into data indicative of a muscle parameter. The computing device is configured to build …
Going With The Flow, Benjamin Borgmann-Winter
State V. Toledo Respondent's Brief Dckt. 48866
Guest Editorial: Power In Engaged Scholarship: Dimensions And Dynamics Of Knowledge Co-Creation, Margaret Post, Morgan Ruelle
Guest Editorial: Power In Engaged Scholarship: Dimensions And Dynamics Of Knowledge Co-Creation, Margaret Post, Morgan Ruelle
Sustainability and Social Justice
Collaboratively engaged research is shaped by dynamic power relationships among individuals, institutions and communities. Where some disciplines have explored the theoretical and methodological implications of power relations, the engagement movement writ large has suffered from a lack of explicit conceptual models and in-depth analyses of the role of power in the process of knowledge co-creation. Over the last 30 years, considerable attention has been paid to how resources and expertise within academic institutions can be brought to bear on the intractable social and economic problems of local communities. A necessary, yet under-theorised aspect of these dynamics is the extent to …
Co-Teaching Strategies: Improving Student Engagement By Increasing Opportunities To Respond, Janet E. Nutt
Co-Teaching Strategies: Improving Student Engagement By Increasing Opportunities To Respond, Janet E. Nutt
Kentucky Teacher Education Journal: The Journal of the Teacher Education Division of the Kentucky Council for Exceptional Children
Research indicates that effective co-teaching using high leverage practices can maximize outcomes across content areas and positively affect student engagement. This paper discusses practical ways to increase student engagement by increasing opportunities to respond in a co-teaching setting. Specific examples are included for a secondary mathematics co-taught classroom, but the principles can be applied in any subject or setting. A proposed model of professional development and coaching to support effective questioning techniques and increase opportunities to respond is also discussed for the purposes of teacher training and professional development.
Using Cec High Leverage Practices To Prepare Teacher Candidates To Meet Individual Student Learning Needs, Michelle A. Gremp Ph.D, Ced, Julie Harp Rutland Ph.D., Maria L. Manning Ph.D., Mary Jo Krile Ph.D.
Using Cec High Leverage Practices To Prepare Teacher Candidates To Meet Individual Student Learning Needs, Michelle A. Gremp Ph.D, Ced, Julie Harp Rutland Ph.D., Maria L. Manning Ph.D., Mary Jo Krile Ph.D.
Kentucky Teacher Education Journal: The Journal of the Teacher Education Division of the Kentucky Council for Exceptional Children
Whether instruction is happening in traditional classroom settings or through a variety of virtual platforms, successful teaching requires that all teachers possess the ability to collaborate with others, evaluate student performance, establish quality learning environments, and individualize instruction. Drawing on the 2017 Council for Exceptional Children (CEC) publication, High-Leverage Practices for K-12 Special Education Teachers (McLeskey et al., 2017), the Special Education faculty at Eastern Kentucky University describe ways in which four intertwined components of collaboration, assessment, social/ emotional/behavioral practices, and instruction are incorporated into teacher preparation courses to equip candidates with skills to meet the individualized learning needs of …
The Why, The Who, The How… A Guide To Planning Effective, Collaborative, Person-Centered Transition Services For Students With Disabilities, Kristie Covington, Lorita Rowlett
The Why, The Who, The How… A Guide To Planning Effective, Collaborative, Person-Centered Transition Services For Students With Disabilities, Kristie Covington, Lorita Rowlett
Kentucky Teacher Education Journal: The Journal of the Teacher Education Division of the Kentucky Council for Exceptional Children
Providing effective transition services and plans for students with disabilities can seem like a daunting task to special education teachers and supporting agencies. Planning effective collaboration and coordination between stakeholders increases the likelihood that students with disabilities will graduate high school and participate in desired postsecondary activities, be it paid employment or postsecondary education (NTACT, 2019). Many special education teachers and supporting agencies are unsure where to start when planning and coordinating transition services; in response we created a document that can be used as a guidance and planning tool to design effective, person-centered, collaborative transition services. The planning tool …
Els In A Michigan 9-12 School: Educators’ Perceptions And Cultural Considerations, Melissa Lynn Dean
Els In A Michigan 9-12 School: Educators’ Perceptions And Cultural Considerations, Melissa Lynn Dean
Masters Theses
This research investigates the perceptions of administrators and specialists in one diversely enrolled Michigan secondary school. Particularly, the purpose was to determine to what extent English learners (ELs), especially those of non-Western backgrounds, are being accommodated and considered by educators and policy. To examine this, three participants were successfully recruited- a language acquisition administrator, a language acquisition specialist, and an assistant principal. They were then each interviewed once to learn of their perceptions and beliefs on these topics. This research finds that although administrators and specialists may be knowledgeable and advocate for their ELs in creative and culturally competent ways, …
Perceptions Of Cardiac Self-Care Among Lebanese Patients And Their Family Caregivers, Nuhad Yazbik Dumit
Perceptions Of Cardiac Self-Care Among Lebanese Patients And Their Family Caregivers, Nuhad Yazbik Dumit
Dissertations
In Lebanon cardiovascular diseases are the leading causes of mortality and morbidity. Assisting people to live with cardiac illness is a problem needing attention. Literature demonstrated significant association between effective self-care practices and secondary prevention of cardiac disease. However, adopting interventions effective in the West may yield different outcomes if not culturally sensitive. The purpose of this study was to explore perceptions of cardiac self-care among Lebanese patients and their family caregivers. The specific aims were to describe the cultural context of self-care in Lebanon, and to explore roles of cardiac patients and caregivers to enhance self-care practices.
Linking Migration To Community Resilience In The Receiving Basin Of A Large-Scale Water Transfer Project, Anna Erwin, Zhao Ma, Ruxandra Popovici, Emma Patricia Salas O’Brien, Laura Zanotti, Chelsea A. Silva, Eliseo Zeballos Zeballos, Jonathan Bauchet, Nelly Ramírez Calderón, Glenn Roberto Arce Larreah
Linking Migration To Community Resilience In The Receiving Basin Of A Large-Scale Water Transfer Project, Anna Erwin, Zhao Ma, Ruxandra Popovici, Emma Patricia Salas O’Brien, Laura Zanotti, Chelsea A. Silva, Eliseo Zeballos Zeballos, Jonathan Bauchet, Nelly Ramírez Calderón, Glenn Roberto Arce Larreah
School of Earth, Environmental, & Marine Sciences Faculty Publications
Large-scale water transfer projects (LWTPs) transfer water to urban and agricultural areas. The Majes-Siguas canal, established in 1983, is an LWTP that created a thriving agricultural area through irrigating the Majes district in the Atacama Desert of Peru. Like other LWTP receiving basins, the project has attracted an influx of migrants who work on the farms. At the same time, the Majes LWTP is the district’s only source of water and has an aging infrastructure which presents significant risks. While many studies critically analyze the consequences of LWTPs in water supply basins, few evaluate the resilience of communities living in …
Dysregulation Of Dna Methylation And Epigenetic Clocks In Prostate Cancer Among Puerto Rican Men, Anders Berglund, Jaime Matta, Jarline Encarnación-Medina, Carmen Ortiz-Sanchéz, Julie Dutil, Raymond Linares, Joshua Marcial, Caren Abreu-Takemura, Natasha Moreno, Ryan Putney, Ratna Chakrabarti, Hui Yi Lin, Kosj Yamoah, Carlos Diaz Osterman, Liang Wang, Jasreman Dhillon, Youngchul Kim, Seung Joon Kim, Gilberto Ruiz-Deya, Jong Y. Park
Dysregulation Of Dna Methylation And Epigenetic Clocks In Prostate Cancer Among Puerto Rican Men, Anders Berglund, Jaime Matta, Jarline Encarnación-Medina, Carmen Ortiz-Sanchéz, Julie Dutil, Raymond Linares, Joshua Marcial, Caren Abreu-Takemura, Natasha Moreno, Ryan Putney, Ratna Chakrabarti, Hui Yi Lin, Kosj Yamoah, Carlos Diaz Osterman, Liang Wang, Jasreman Dhillon, Youngchul Kim, Seung Joon Kim, Gilberto Ruiz-Deya, Jong Y. Park
School of Public Health Faculty Publications
In 2021, approximately 248,530 new prostate cancer (PCa) cases are estimated in the United States. Hispanic/Latinos (H/L) are the second largest racial/ethnic group in the US. The objective of this study was to assess DNA methylation patterns between aggressive and indolent PCa along with ancestry proportions in 49 H/L men from Puerto Rico (PR). Prostate tumors were classified as aggressive (n = 17) and indolent (n = 32) based on the Gleason score. Genomic DNA samples were extracted by macro-dissection. DNA methylation patterns were assessed using the Illumina EPIC DNA methylation platform. We used ADMIXTURE to estimate global ancestry proportions. …
State Of Utah, Plaintiff/Appellee V, Joshua Martin, Defendant/Appellant : Brief Of Appellant, Utah Court Of Appeals
State Of Utah, Plaintiff/Appellee V, Joshua Martin, Defendant/Appellant : Brief Of Appellant, Utah Court Of Appeals
Utah Court of Appeals Briefs (2020 –)
Appeal from the Fourth District Court, Utah County, from Judgement on post-conviction relief before the Honorable James Brady
SEAN REYES, Counsel for Appellee
OSHUA MARTIN, Pro se
Approval Among Democrats Fuels Uptick In Biden Approval In Granite State 12/21/2021, Unh Survey Center
Approval Among Democrats Fuels Uptick In Biden Approval In Granite State 12/21/2021, Unh Survey Center
All UNH Survey Center Polls
President Joe Biden's approval rating has improved slightly, with state residents now evenly divided in their assessment of his job performance. Biden's approval among Democrats, which had declined for months, now matches marks from earlier in his presidency. Slim majorities disapprove of Biden's handling of foreign affairs and the economy, but a small majority approve of his handling of COVID-19. Only a quarter of Granite Staters feel the country is headed in the right direction.
Perinatal Corticosteroids: Latent Neurodevelopment Of The Preterm Infant, Isabell Biene Purdy
Perinatal Corticosteroids: Latent Neurodevelopment Of The Preterm Infant, Isabell Biene Purdy
Dissertations
The purpose of this study was to evaluate potential relationships between perinatal dexamethasone treatment of premature infants and latent child development. Often, postnatal corticosteroid (PNS) is offered in the neonatal intensive care unit (NICU) to wean mechanical ventilation. Experts suggested minimizing PNS use after studies identified higher milligrams per kilogram (mg/kg) as a risk factor for adverse developmental outcomes. This study quantified fetal dexamethasone and cumulative perinatal dexamethasone by mg/kg exposure to accurately assess associations between steroid exposure and premature infant behavioral development.
Informing Effective Simulation Pedagogy In Nursing Simulation, Sherry L. Barnard
Informing Effective Simulation Pedagogy In Nursing Simulation, Sherry L. Barnard
Dissertations
Simulation methods are now widely used in nursing education programs. Several studies have been conducted that examine the effect of simulation on student outcomes in learning (Alinier, Hunt, Gordon, & Harwood, 2006; Arnold, et al, 2009; Rosen, Salas, Silvestri, Wu, & Lazzara, 2008), however, little has been discovered regarding models of faculty support and guidance during simulation. The factors that influence student learning in the simulation experience suggest faculty be a guide by offering cueing and support before, during, and after the simulation process (Parsh, Roberts, & Green, 2010). It is also suggested that debriefing be non-judgmental and a time …
A Nationally Representative Survey Of Depression Symptoms Among Jordanian Adolescents: Associations With Depression Stigma, Depression Etiological Beliefs, And Likelihood To Seek Help For Depression, Latefa Ali Dardas
Dissertations
Arab adolescents are considered a particularly vulnerable population to depression. The substantial lack of mental health services and the stigma associated with mental illness on the one hand; and poverty, unemployment, and lack of reasonable hopes for a decent future in the context of corruption of regimes and perceived social injustice on the other, call for establishing committed and effective policies to tackle depression and its associated stigma among Arab adolescents at risk for or diagnosed with depression. However, there is a substantial lack of research that can inform the current profile of adolescent depression in the Arab region. We …
The Health-Related Quality Of Life Of Adults With Down Syndrome, Rebecca Jermyn Graves
The Health-Related Quality Of Life Of Adults With Down Syndrome, Rebecca Jermyn Graves
Dissertations
The purpose of this study was to examine the health-related quality of life (HRQOL) and factors associated with the HRQOL of adults with Down syndrome (DS) as reported by adults with DS and their caregivers. The study was designed to compare measures of HRQOL, health problems, health risks, and health-care utilization of adults with DS based on self-report with those from caregiver-report and to explore associations between HRQOL and health problems, health risks, health-care utilization, adaptive behavior, and demographic characteristics.
Police Use Of Social Media Technologies, Akpomudiare Darlynton Adegor
Police Use Of Social Media Technologies, Akpomudiare Darlynton Adegor
Theses and Dissertations
This study used a qualitative research design to analyze how the Little Rock Police Department (LRPD) utilizes social media technologies to promote its community policing philosophy. I conducted a content analysis on 586 tweets by LRPD and 992 public responses posted between May 2020 and May 2021. From my analysis, I found that LRPD social media platforms support both community policing and problem-solving. LRPD uses social media for interactions, connections, and partnerships with community members. The second notable finding was that the public is responsive and receptive to LRPD’s use of social media to connect with them. However, LRPD’s level …
Simulated Presence Use For Quality Of Life Maintenance And Reduction Of Symptoms Of Distress In Persons Living With Dementia In Long-Term Care, Erin E. Bush
Dissertations
Nursing home residents with dementia often have an array of neuropsychiatric symptoms, including dementia-related agitation. It is theorized that many of these agitation symptoms occur due to unmet psychosocial needs that could be met by the presence of a caring nursing staff member, family member, or friend.
The purpose of this study was to determine whether live simulated presence improves dementia-related agitation when offered, identify barriers and facilitators to simulated presence between caregivers and residents of long-term care during the COVID-19 pandemic, and to determine if live simulated presence by a caregiver delivered one-on-one improved quality of life in long-term …
Kinematics And Kinetics Of Capacitated And Non-Capacitated Mouse Sperm, Alicia Gupte
Kinematics And Kinetics Of Capacitated And Non-Capacitated Mouse Sperm, Alicia Gupte
Mechanical Engineering and Materials Science Independent Study
The differences in kinetic measurements of force, work, power, and torque are quantitativly observed between non-capacitated and capacitated sperm. Isomap, a nonlinear dimensionality reduction technique, is used to get higher resolution imaging data of the sperm videos. This allowed accurate calculations of spatial and temporal derivatives to calculate the kinetics of the flagella. The results showed no statistical significance between the kinetic measurements of non- capacitated and capacitated mouse sperm.
Randomized Controlled Trial Of Early Outpatient Covid-19 Treatment With High-Titer Convalescent Plasma, David J. Sullivan, Kelly A. Gebo, Shmuel Shoham, Bryan Lau, Aarthi G G Shenoy, Giselle S. Mosnaim, Thomas J. Gniadek, Yuriko Fukuta, Bela Patel, Sonya L. Heath, Adam C. Levine, Barry R. Meisenberg, Emily S. Spivak, Shweta Anjan, Moises A. Huaman, Janis E. Blair, Judith S. Currier, James H. Paxton, Jonathan M. Gerber, Joann R. Petrini, Patrick B. Broderick, William Rausch, Marie Elena Cordisco, Jean Hammel, Benjamin Greenblatt, Daniel Cruser, Kevin Oei, Matthew Abinante, Laura L. Hammitt, Catherine G. Sutcliffe, Donald N. Forthal, Martin S. Zand, Edward R. Cachay, Jay S. Raval, Seble G. Kassaye, E Colin Foster, Michael Roth, Christi E. Marshall, Anusha Yarava, Karen Lane, Nichol A. Mcbee, Amy L. Gawad, Nicky Karlen, Atika Singh, Daniel E. Ford, Douglas A. Jabs, Lawrence J. Appel, David M. Shade, Stephan Ehrhardt, Sheriza N. Baksh, Oliver Laeyendecker, Andrew Pekosz, Sabra L. Klein, Arturo Casadevall, Aaron A R Tobian, Daniel F. Hanley, Evan M. Bloch, Valerie C. Cluzet
Randomized Controlled Trial Of Early Outpatient Covid-19 Treatment With High-Titer Convalescent Plasma, David J. Sullivan, Kelly A. Gebo, Shmuel Shoham, Bryan Lau, Aarthi G G Shenoy, Giselle S. Mosnaim, Thomas J. Gniadek, Yuriko Fukuta, Bela Patel, Sonya L. Heath, Adam C. Levine, Barry R. Meisenberg, Emily S. Spivak, Shweta Anjan, Moises A. Huaman, Janis E. Blair, Judith S. Currier, James H. Paxton, Jonathan M. Gerber, Joann R. Petrini, Patrick B. Broderick, William Rausch, Marie Elena Cordisco, Jean Hammel, Benjamin Greenblatt, Daniel Cruser, Kevin Oei, Matthew Abinante, Laura L. Hammitt, Catherine G. Sutcliffe, Donald N. Forthal, Martin S. Zand, Edward R. Cachay, Jay S. Raval, Seble G. Kassaye, E Colin Foster, Michael Roth, Christi E. Marshall, Anusha Yarava, Karen Lane, Nichol A. Mcbee, Amy L. Gawad, Nicky Karlen, Atika Singh, Daniel E. Ford, Douglas A. Jabs, Lawrence J. Appel, David M. Shade, Stephan Ehrhardt, Sheriza N. Baksh, Oliver Laeyendecker, Andrew Pekosz, Sabra L. Klein, Arturo Casadevall, Aaron A R Tobian, Daniel F. Hanley, Evan M. Bloch, Valerie C. Cluzet
Pathology Research and Scholarship
BACKGROUND: The efficacy of polyclonal high titer convalescent plasma to prevent serious complications of COVID-19 in outpatients with recent onset of illness is uncertain.
METHODS: This multicenter, double-blind randomized controlled trial compared the efficacy and safety of SARS-CoV-2 high titer convalescent plasma to placebo control plasma in symptomatic adults ≥18 years positive for SARS-CoV-2 regardless of risk factors for disease progression or vaccine status. Participants with symptom onset within 8 days were enrolled, then transfused within the subsequent day. The measured primary outcome was COVID-19-related hospitalization within 28 days of plasma transfusion. The enrollment period was June 3, 2020 to …
A Hybrid Machine Learning Framework For Predicting Students’ Performance In Virtual Learning Environment, Edmund Evangelista
A Hybrid Machine Learning Framework For Predicting Students’ Performance In Virtual Learning Environment, Edmund Evangelista
All Works
Virtual Learning Environments (VLE), such as Moodle and Blackboard, store vast data to help identify students' performance and engagement. As a result, researchers have been focusing their efforts on assisting educational institutions in providing machine learning models to predict at-risk students and improve their performance. However, it requires an efficient approach to construct a model that can ultimately provide accurate predictions. Consequently, this study proposes a hybrid machine learning framework to predict students' performance using eight classification algorithms and three ensemble methods (Bagging, Boosting, Voting) to determine the best-performing predictive model. In addition, this study used filter-based and wrapper-based feature …
Linking Migration To Community Resilience In The Receiving Basin Of A Large-Scale Water Transfer Project, Anna Erwin, Zhao Ma, Ruxandra Popovici, Emma Patricia Salas O’Brien, Laura Zanotti, Chelsea A. Silva, Eliseo Zeballos Zeballos, Jonathan Bauchet, Nelly Ramírez Calderón, Glenn Roberto Arce Larrea
Linking Migration To Community Resilience In The Receiving Basin Of A Large-Scale Water Transfer Project, Anna Erwin, Zhao Ma, Ruxandra Popovici, Emma Patricia Salas O’Brien, Laura Zanotti, Chelsea A. Silva, Eliseo Zeballos Zeballos, Jonathan Bauchet, Nelly Ramírez Calderón, Glenn Roberto Arce Larrea
Department of Agricultural Economics Faculty Publications
Large-scale water transfer projects (LWTPs) transfer water to urban and agricultural areas. The Majes-Siguas canal, established in 1983, is an LWTP that created a thriving agricultural area through irrigating the Majes district in the Atacama Desert of Peru. Like other LWTP receiving basins, the project has attracted an influx of migrants who work on the farms. At the same time, the Majes LWTP is the district’s only source of water and has an aging infrastructure which presents significant risks. While many studies critically analyze the consequences of LWTPs in water supply basins, few evaluate the resilience of communities living in …
Tricuspid Valve Intervention At The Time Of Pulmonary Valve Replacement In Adults With Congenital Heart Disease: A Systematic Review And Meta-Analysis, Jef Van Den Eynde, Connor P Callahan, Mauro Lo Rito, Nabil Hussein, Horacio Carvajal, Alvise Guariento, Arjang Ruhparwar, Alexander Weymann, Werner Budts, Marc Gewillig, Michel Pompeu Sá, Shelby Kutty
Tricuspid Valve Intervention At The Time Of Pulmonary Valve Replacement In Adults With Congenital Heart Disease: A Systematic Review And Meta-Analysis, Jef Van Den Eynde, Connor P Callahan, Mauro Lo Rito, Nabil Hussein, Horacio Carvajal, Alvise Guariento, Arjang Ruhparwar, Alexander Weymann, Werner Budts, Marc Gewillig, Michel Pompeu Sá, Shelby Kutty
Open Access Publications
Background Tricuspid regurgitation (TR) is a common finding in adults with congenital heart disease referred for pulmonary valve replacement (PVR). However, indications for combined valve surgery remain controversial. This study aimed to evaluate early results of concomitant tricuspid valve intervention (TVI) at the time of PVR. Methods and Results Observational studies comparing TVI+PVR and isolated PVR were identified by a systematic search of published research. Random-effects meta-analysis was performed, comparing outcomes between the 2 groups. Six studies involving 749 patients (TVI+PVR, 278 patients; PVR, 471 patients) met the eligibility criteria. In the pooled analysis, both TVI+PVR and PVR reduced TR …
Myeloid-Derived Suppressor Cells Mediate T Cell Dysfunction In Nonhuman Primate Tb Granulomas, Bindu Singh, Dhiraj K Singh, Shashank R Ganatra, Ruby A Escobedo, Shabaana Khader, Larry S Schlesinger, Deepak Kaushal, Smriti Mehra
Myeloid-Derived Suppressor Cells Mediate T Cell Dysfunction In Nonhuman Primate Tb Granulomas, Bindu Singh, Dhiraj K Singh, Shashank R Ganatra, Ruby A Escobedo, Shabaana Khader, Larry S Schlesinger, Deepak Kaushal, Smriti Mehra
Open Access Publications
Myeloid-derived suppressor cells (MDSCs) represent an innate immune cell population comprised of immature myeloid cells and myeloid progenitors with very potent immunosuppressive potential. MDSCs are reported to be abundant in the lungs of active tuberculosis (TB) patients. We sought to perform an in-depth study of MDSCs during latent TB infection (LTBI) and active TB (ATB) using the nonhuman primate (NHP) model of pulmonary TB. We found a higher proportion of granulocytic, polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) in the lungs of ATB animals compared to those with LTBI or naive control animals. Active disease in the lung, but not LTBI, was …
Ccr2 Signaling Restricts Sars-Cov-2 Infection, Abigail Vanderheiden, Jeronay Thomas, Allison L Soung, Meredith E Davis-Gardner, Katharine Floyd, Fengzhi Jin, David A Cowan, Kathryn Pellegrini, Pei-Yong Shi, Arash Grakoui, Robyn S Klein, Steven E Bosinger, Jacob E Kohlmeier, Vineet D Menachery, Mehul S Suthar
Ccr2 Signaling Restricts Sars-Cov-2 Infection, Abigail Vanderheiden, Jeronay Thomas, Allison L Soung, Meredith E Davis-Gardner, Katharine Floyd, Fengzhi Jin, David A Cowan, Kathryn Pellegrini, Pei-Yong Shi, Arash Grakoui, Robyn S Klein, Steven E Bosinger, Jacob E Kohlmeier, Vineet D Menachery, Mehul S Suthar
Open Access Publications
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a historic pandemic of respiratory disease (coronavirus disease 2019 [COVID-19]), and current evidence suggests that severe disease is associated with dysregulated immunity within the respiratory tract. However, the innate immune mechanisms that mediate protection during COVID-19 are not well defined. Here, we characterize a mouse model of SARS-CoV-2 infection and find that early CCR2 signaling restricts the viral burden in the lung. We find that a recently developed mouse-adapted SARS-CoV-2 (MA-SARS-CoV-2) strain as well as the emerging B.1.351 variant trigger an inflammatory response in the lung characterized by the expression of …