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2021

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Autoimmunity In Psoriatic Arthritis: Pathophysiological And Clinical Aspects, Hakan Emmungi̇l, Ufuk İlgen, Rafi̇ Haner Di̇reskeneli̇ Jan 2021

Autoimmunity In Psoriatic Arthritis: Pathophysiological And Clinical Aspects, Hakan Emmungi̇l, Ufuk İlgen, Rafi̇ Haner Di̇reskeneli̇

Turkish Journal of Medical Sciences

Psoriatic arthritis (PsA) is an underdiagnosed entity with a broad impact on the quality of life. Although the pathogenesis is largely unknown, autoimmune footprints of the inflammation in PsA have increasingly been recognized. Most of the genetic variation predisposing to PsA is mapped to the class I major histocompatibility complex (MHC) region and shared by a variety of autoimmune diseases. Polymorphisms in the genes IL12B, IL23R, IL13, TNIP1, TRAF3IP2, TYK2, and many others explain the nonHLA genetic risk with little known functional consequences. Entheseal and synovial cellular infiltrate with oligoclonal CD8+ T cells and occasional germinal centers, loss of regulatory …

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Covid-19 Clinical Course And Blood Groups: Turkish Population-Based Study, Mehmet Si̇nan Dal, Nai̇m Ata, Fevzi̇ Altuntaş, Semi̇h Başci, Tuğçe Nur Yi̇ğenoğlu, Serdal Korkmaz, Si̇nem Namdaroğlu, Abdulkadi̇r Baştürk, Tuba Hacibeki̇roğlu, Mehmet Hi̇lmi̇ Doğu, İlhami̇ Berber, Kürşat Dal, Mehmet Ali̇ Erkurt, Burhan Turgut, Murat Çağlayan Jan 2021

Covid-19 Clinical Course And Blood Groups: Turkish Population-Based Study, Mehmet Si̇nan Dal, Nai̇m Ata, Fevzi̇ Altuntaş, Semi̇h Başci, Tuğçe Nur Yi̇ğenoğlu, Serdal Korkmaz, Si̇nem Namdaroğlu, Abdulkadi̇r Baştürk, Tuba Hacibeki̇roğlu, Mehmet Hi̇lmi̇ Doğu, İlhami̇ Berber, Kürşat Dal, Mehmet Ali̇ Erkurt, Burhan Turgut, Murat Çağlayan

Turkish Journal of Medical Sciences

Background/aim: SARS-CoV-2 enters the cell through the binding of the S glycoprotein on the surface of the virus to the angiotensinconverting enzyme 2 (ACE-2) in the host cells and also SARS-CoV S protein binding to ACE-2 was inhibited by anti-A antibodies. The aim of the study was to investigate the relationship between blood groups and the course of COVID-19 in Turkey. Materials and methods: Laboratory confirmed COVID-19 patients aged 18 and over (n = 39.850) were randomized in age and sexmatched groups according to blood groups Results: Advanced age, male sex and blood group A were found to be related …

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Nutritional Status In Patients With Neuro-Behçet's Disease, Seyda Erdoğan, Mi̇ne Hayri̇ye Sorgun, Müge Kuzu Kumcu, Mustafa Aykut Kural, Sefer Rzayev, Canan Yücesan Jan 2021

Nutritional Status In Patients With Neuro-Behçet's Disease, Seyda Erdoğan, Mi̇ne Hayri̇ye Sorgun, Müge Kuzu Kumcu, Mustafa Aykut Kural, Sefer Rzayev, Canan Yücesan

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to assess the nutritional status and risk factors for malnutrition in Behçet's disease (BD) and neuro-Behçet's disease (NBD) patients. Materials and methods: Medical recordings of 74 patients with BD without neurological involvement (BDWoNI), 72 patients with NBD, and 50 patients with other diseases (carpal tunnel syndrome or lumbar discopathy) were analyzed retrospectively. The serum analyses were performed in the inactive period of disease. Chronic malnutrition was defined as low levels of serum albumin (

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Long-Term Proton Pump Inhibitor Use Is A Risk Factor For Mortality In Patientshospitalized For Covid-19, Ahmet Yozgat, Benan Kasapoğlu, Güray Can, Alpaslan Tanoğlu, Yusuf Serdar Saki̇n, Kadi̇r Serkan Yalçin, Müjgan Gürler, Mustafa Kaplan, Mehmet Göktürk Kaban, Mehmet Kirsoy, Umut Kara, Murat Keki̇lli̇ Jan 2021

Long-Term Proton Pump Inhibitor Use Is A Risk Factor For Mortality In Patientshospitalized For Covid-19, Ahmet Yozgat, Benan Kasapoğlu, Güray Can, Alpaslan Tanoğlu, Yusuf Serdar Saki̇n, Kadi̇r Serkan Yalçin, Müjgan Gürler, Mustafa Kaplan, Mehmet Göktürk Kaban, Mehmet Kirsoy, Umut Kara, Murat Keki̇lli̇

Turkish Journal of Medical Sciences

Background and aim: The aim of this study is to evaluate whether the long-term (≥4 weeks) use of proton pump inhibitors (PPIs) is a risk factor for intubation requirement and mortality in patients hospitalized for COVID-19. Materials and methods: In this multicentric retrospective study, a total of 382 adult patients (≥18 years of age) with confirmed COVID-19 who were hospitalized for treatment were enrolled. The patients were divided into two groups according to the periods during which they used PPIs: the first group included patients who were not on PPI treatment, and the second group included those who have used …

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Risk Factors Associated With Mortality In Intensive Care Covid-19 Patients: Theimportance Of Chest Ct Score And Intubation Timing As Risk Factors, Veci̇he Bayrak, Nurcan Şentürk Durukan, Ferhan Demi̇rer Aydemi̇r, Begüm Ergan, Naci̇ye Si̇nem Gezer, Oya Özlem Eren Kutsoylu, Ali̇ Necati̇ Gökmen, Yusuf Savran Jan 2021

Risk Factors Associated With Mortality In Intensive Care Covid-19 Patients: Theimportance Of Chest Ct Score And Intubation Timing As Risk Factors, Veci̇he Bayrak, Nurcan Şentürk Durukan, Ferhan Demi̇rer Aydemi̇r, Begüm Ergan, Naci̇ye Si̇nem Gezer, Oya Özlem Eren Kutsoylu, Ali̇ Necati̇ Gökmen, Yusuf Savran

Turkish Journal of Medical Sciences

Background/aim: Coronavirus disease 2019 (COVID-19) is a disease with a high rate of progression to critical illness. However, the predictors of mortality in critically ill patients admitted to the intensive care unit (ICU) are not yet well understood. In this study, we aimed to investigate the risk factors associated with ICU mortality in our hospital. Materials and methods: In this single-centered retrospective study, we enrolled 86 critically ill adult patients with COVID-19 admitted to ICU of Dokuz Eylül University Hospital (İzmir, Turkey) between 18 March 2020 and 31 October 2020. Data on demographic information, preexisting comorbidities, treatments, the laboratory findings …

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Decreased Exercise Capacity, Strength, Physical Activity Level And Quality Of Life In Adultpatients With Familial Mediterranean Fever, Nurten Gi̇zem Tore, Fulden Sari̇, Devri̇m Can Saraç, Seli̇n Bayram, Hasan Satiş, Hazan Karadeni̇z, Abdurrahman Tufan, Deran Oskay Jan 2021

Decreased Exercise Capacity, Strength, Physical Activity Level And Quality Of Life In Adultpatients With Familial Mediterranean Fever, Nurten Gi̇zem Tore, Fulden Sari̇, Devri̇m Can Saraç, Seli̇n Bayram, Hasan Satiş, Hazan Karadeni̇z, Abdurrahman Tufan, Deran Oskay

Turkish Journal of Medical Sciences

Background: Familial Mediterranean fever (FMF) is a systemic autoinflammatory disease that causes recurrent attacks of fever, polyserositis, arthritis or skin eruptions, resulting in pain in the abdomen, muscles, joints and chest. All of these might lead to a reduction in exercise capacity, muscle strength, physical activity level (PAL) and quality of life (QoL). Therefore, assesment of these parameters are important. The aim of this study was to assess exercise capacity, muscle strength, PAL, and QoL in patients with FMF as compared to controls. Materials and methods: A total of 40 subjects with FMF and 36 healthy control subjects participated in …

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Appendectomy History Is Associated With Severe Disease And Colchicine Resistance In Adultfamilial Mediterranean Fever Patients, Erdal Bodakçi̇, Nazi̇fe Şule Yaşar Bi̇lge, Nuh Ataş, Berkan Armağan, Hasan Satiş, Alper Sari, Reyhan Bi̇li̇ci̇ Salman, Gözde Kübra Yardimci, Hakan Babaoğlu, Levent Kiliç, Mehmet Aki̇f Öztürk, Berna Göker, Şemi̇nur Haznedaroğlu, Umut Kalyoncu, Abdurrahman Tufan Jan 2021

Appendectomy History Is Associated With Severe Disease And Colchicine Resistance In Adultfamilial Mediterranean Fever Patients, Erdal Bodakçi̇, Nazi̇fe Şule Yaşar Bi̇lge, Nuh Ataş, Berkan Armağan, Hasan Satiş, Alper Sari, Reyhan Bi̇li̇ci̇ Salman, Gözde Kübra Yardimci, Hakan Babaoğlu, Levent Kiliç, Mehmet Aki̇f Öztürk, Berna Göker, Şemi̇nur Haznedaroğlu, Umut Kalyoncu, Abdurrahman Tufan

Turkish Journal of Medical Sciences

Background/aim: Peritonitis attacks of Familial Mediterranean Fever (FMF) usually requires emergency medical admissions and it's hard to distinguish a typical abdominal attack from surgical causes of acute abdomen. Therefore, history of abdominal surgery, particularly appendectomy, is very common in patients with FMF. However, history of appendectomy might also give some clues about the course of FMF in the adulthood. This study was to determine whether the history of appendectomy help to anticipate disease course of FMF in the adulthood. Materials and methods: All patients recruited from FMF in Central Anatolia (FiCA) cohort, comprising 971 adult subjects. All patients fulfilled the …

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Factors Affecting Relapse In Patients With Granulomatosis Polyangiitis: A Single-Centerretrospective Cohort Study, Müge Aydin Tufan, Ni̇han Tekkarişmaz, Ahmet Eftal Yücel Jan 2021

Factors Affecting Relapse In Patients With Granulomatosis Polyangiitis: A Single-Centerretrospective Cohort Study, Müge Aydin Tufan, Ni̇han Tekkarişmaz, Ahmet Eftal Yücel

Turkish Journal of Medical Sciences

Background and aim: This study aimed to determine the frequency of relapse, the risk factors for relapse, and the correlation of relapse with immunosuppressive regimens in patients with granulomatosis polyangiitis (GPA). Materials and methods: The demographic characteristics, the clinical, laboratory, and radiological findings, the immunosuppressive treatment regimens, and the remission and relapse rates of 50 patients with GPA were obtained retrospectively from medical records. Results: The mean relapse-free survival rates at years 1, 3, and 5 were 82%, 60%, and 50%, respectively. Increased relapse rates were observed in patients who had cavitary lung lesions (52.2% vs. 22.2%, p = 0.04) …

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Pediatric Extracorporeal Cardiopulmonary Resuscitation: Single-Center Study, Tanil Kendi̇rli̇, Serhan Özcan, Merve Havan, Çağdaş Baran, Mehmet Çakici, Burcu Arici, Özlem Selvi̇ Can, Zeynep Eyi̇leten, Tayfun Uçar, Hasan Ercan Tutar, Ahmet Rüçhan Akar Jan 2021

Pediatric Extracorporeal Cardiopulmonary Resuscitation: Single-Center Study, Tanil Kendi̇rli̇, Serhan Özcan, Merve Havan, Çağdaş Baran, Mehmet Çakici, Burcu Arici, Özlem Selvi̇ Can, Zeynep Eyi̇leten, Tayfun Uçar, Hasan Ercan Tutar, Ahmet Rüçhan Akar

Turkish Journal of Medical Sciences

Background/aim: Extracorporeal cardiopulmonary resuscitation (ECPR) is defined as the venoarterial extracorporeal membrane oxygenation (VA-ECMO) support in a patient who experienced a sudden pulseless condition attributable to cessation of cardiac mechanical activity and circulation. We aimed to evaluate the clinical outcomes of our ECPR experience in a pediatric patient population. Materials and methods: Between September 2014 and November 2017, 15 children were supported with ECPR following in-hospital cardiac arrest (IHCA) in our hospitals. VA-ECMO setting was established for all patients. Pediatric cerebral performance category (PCPC) scales and long-term neurological prognosis of the survivors were assessed. Results: The median age of the …

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The Relationship Of Carotid Intima-Media Thickness With Anthropometric And Metabolicparameters In Patients With Classic Congenital Adrenal Hyperplasia, Hale Ünver Tuhan, Tülay Öztürk Atasoy, Gönül Çatli, Sezer Acar, Ayhan Abaci, Tuğba Üçüncü Egeli̇, Korcan Demi̇r, Penbe Şule Can, Handan Güleryüz, Bumi̇n Nuri̇ Dündar, Ece Böber Jan 2021

The Relationship Of Carotid Intima-Media Thickness With Anthropometric And Metabolicparameters In Patients With Classic Congenital Adrenal Hyperplasia, Hale Ünver Tuhan, Tülay Öztürk Atasoy, Gönül Çatli, Sezer Acar, Ayhan Abaci, Tuğba Üçüncü Egeli̇, Korcan Demi̇r, Penbe Şule Can, Handan Güleryüz, Bumi̇n Nuri̇ Dündar, Ece Böber

Turkish Journal of Medical Sciences

Background/aim: We aimed to determine the presence of subclinical atherosclerosis using carotid intima-media thickness (CIMT) and biochemical parameters in children and adolescents with congenital adrenal hyperplasia (CAH). Materials and methods: Thirty-four patients with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency on regular glucocorticoid treatment for ≥3 years and 31 healthy subjects were included in the study. The patients were divided into two groups according to the degree of control of the clinic, laboratory, and radiological parameters as a) "uncontrolled" [n= 22; with increased height velocity (HV) standard deviation score (SDS) (≥2 SDS), advanced bone age, serum 17-OH progesterone 0.05]. …

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Attention-Deficit Hyperactivity Disorder Symptoms And Quality Of Life In Female Patientswith Fibromyalgia, Gözde Türkoğlu, Yavuz Selvi̇ Jan 2021

Attention-Deficit Hyperactivity Disorder Symptoms And Quality Of Life In Female Patientswith Fibromyalgia, Gözde Türkoğlu, Yavuz Selvi̇

Turkish Journal of Medical Sciences

Background/aim: The present study aimed to determine the association between attention-deficit hyperactivity disorder (ADHD) symptoms severity, fibromyalgia (FM) severity, and QoL. Materials and methods: While the FM group consisted of 113 (74%) patients, the control group consisted of 40 (26%) individuals. FM symptom severity, ADHD symptom severity, and QoL were evaluated using the fibromyalgia impact questionnaire (FIQ), adult ADHD self-report scale (ASRS), and World Health Organization quality of life scale-brief version (WHOQOL-BREF), respectively. Results: It was found that the FM group had significantly higher scores on the ASRS than the control group (p < 0.05). There was a significant difference in FIQ scores and three WHOQOL-BREF domain scores between the FM alone and comorbid FM/high probability of ADHD groups (p < 0.05). We found a negative correlation between ASRS total scores and all other scale scores (except for the social relationships domain score of the WHOQOL-BREF) and a positive correlation between ASRS total scores and FIQ scores in FM patients. ADHD scores would mediate the relationship between depression severity and QoL. Conclusions: Our findings indicated that the presence of ADHD symptoms was related to greater FM symptom severity and poorer QoL. Also, ADHD scores would mediate the relationship between depression severity and QoL.

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The Use Of High-Flow Nasal Oxygen Vs. Standard Oxygen Therapy In Hematologicalmalignancy Patients With Acute Respiratory Failure In Hematology Wards, Ni̇lgün Özlem Alpteki̇noğlu Mendi̇l, Şahi̇n Temel, Recep Ci̇van Yüksel, Kürşat Gündoğan, Bülent Eser, Leylagül Kaynar, Murat Sungur Jan 2021

The Use Of High-Flow Nasal Oxygen Vs. Standard Oxygen Therapy In Hematologicalmalignancy Patients With Acute Respiratory Failure In Hematology Wards, Ni̇lgün Özlem Alpteki̇noğlu Mendi̇l, Şahi̇n Temel, Recep Ci̇van Yüksel, Kürşat Gündoğan, Bülent Eser, Leylagül Kaynar, Murat Sungur

Turkish Journal of Medical Sciences

Background/aim: High flow nasal cannula (HFNC) was mostly used in intensive care units (ICUs) with few studies in other departments. We hypothesized that HFNC applied at wards is beneficial for acute respiratory failure in hematological malignancy patients. Materials and methods: The study is a single center, randomized controlled study. Inclusion criteria were hypoxemic respiratory failure and hematological malignancy. Patients were randomized to either venturi mask/nasal cannula oxygen treatment or HFNC. Results: One hundred patients were included in the study. Median age was 58.5 (18-86) years and APACHE II score was 17 (5-29). HFNC group was 51 patients and the oxygen …

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Investigating Differential Mirna Expression Profiling Using Serum And Urine Specimensfor Detecting Potential Biomarkers For Early Prostate Cancer Diagnosis, Sevde Hasanoğlu, Beyza Servet Göncü, Emrah Yücesan, Sezen Atasoy, Yunus Kayali, Nur Özten Kandaş Jan 2021

Investigating Differential Mirna Expression Profiling Using Serum And Urine Specimensfor Detecting Potential Biomarkers For Early Prostate Cancer Diagnosis, Sevde Hasanoğlu, Beyza Servet Göncü, Emrah Yücesan, Sezen Atasoy, Yunus Kayali, Nur Özten Kandaş

Turkish Journal of Medical Sciences

Background/aim: MicroRNAs (miRNAs) are known up-to-date candidate biomarkers for several diseases. In addition, obtaining miRNA from different body fluids such as serum, plasma, saliva, and urine is relatively easy to handle. Herein we aimed to detect miRNAs as biomarkers for early stage prostate cancer (PC). For this purpose, we used urine and serum samples to detect any significant differences in miRNA profiles between patients and healthy controls. Materials and methods: Total ribonucleic acid (RNA) in urine and serum samples were isolated from eight untreated PC patients, thirty healthy individuals were screened for miRNA profile, and candidate miRNAs were validated. Whole …

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20-Year Experience On Prenatal Diagnosis In A Reference University Medical Geneticscenter In Turkey, Mehmet Burak Durmaz, Hi̇lmi̇ Bolat, Zehra Cengi̇si̇z, Fuat Akercan, Tuba Sözen Türk, Erhan Pariltay, Asli Ece Solmaz, Mert Kazandi, Emi̇n Karaca, Asude Durmaz, Ayça Aykut, Sermet Sağol, Haluk Akin, Feri̇ştah Ferda Özkinay, Muhsi̇n Özgür Çoğulu Jan 2021

20-Year Experience On Prenatal Diagnosis In A Reference University Medical Geneticscenter In Turkey, Mehmet Burak Durmaz, Hi̇lmi̇ Bolat, Zehra Cengi̇si̇z, Fuat Akercan, Tuba Sözen Türk, Erhan Pariltay, Asli Ece Solmaz, Mert Kazandi, Emi̇n Karaca, Asude Durmaz, Ayça Aykut, Sermet Sağol, Haluk Akin, Feri̇ştah Ferda Özkinay, Muhsi̇n Özgür Çoğulu

Turkish Journal of Medical Sciences

Background/aim: Although cutting edge procedures such as cell-free fetal DNA isolation from maternal blood are now available, invasive prenatal tests are still being used extensively for prenatal diagnosis. The study aims to evaluate the demographic data, indications, and cytogenetic results of 9297 results of patients who underwent prenatal invasive testing for genetic analysis that were referred for the last 20 years in a University Medical Genetics Center. Materials and methods: The records of 8363 amniocenteses, 626 chorionic villus, and 308 cordocenteses samples were retrospectively evaluated and analyzed regarding referral reasons, indications and their cytogenetic results. The total numbers and the …

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Rituximab Treatment For Difficult-To-Treat Nephrotic Syndrome In Children:A Multicenter, Retrospective Study, Mehmet Taşdemi̇r, Nur Canpolat, Nurdan Yildiz, Gül Özçeli̇k, Meryem Benzer, Seha Kami̇l Saygili, Emi̇ne Neşe Özkayin, Özde Ni̇sa Türkkan, Ayşe Balat, Cengi̇z Candan, Mehtap Çelakil, Sevgi̇ Yavuz, Nurver Akinci, Ni̇lüfer Göknar, Ci̇hangi̇r Akgün Jan 2021

Rituximab Treatment For Difficult-To-Treat Nephrotic Syndrome In Children:A Multicenter, Retrospective Study, Mehmet Taşdemi̇r, Nur Canpolat, Nurdan Yildiz, Gül Özçeli̇k, Meryem Benzer, Seha Kami̇l Saygili, Emi̇ne Neşe Özkayin, Özde Ni̇sa Türkkan, Ayşe Balat, Cengi̇z Candan, Mehtap Çelakil, Sevgi̇ Yavuz, Nurver Akinci, Ni̇lüfer Göknar, Ci̇hangi̇r Akgün

Turkish Journal of Medical Sciences

Background/aim: This study aimed to evaluate the efficacy of rituximab in children with difficult-to-treat nephrotic syndrome, considering the type of disease (steroid-sensitive or -resistant) and the dosing regimen. Materials and methods: This multicenter retrospective study enrolled children with difficult-to-treat nephrotic syndrome on rituximab treatment from 13 centers. The patients were classified based on low (single dose of 375 mg/m2 ) or high (2-4 doses of 375 mg/m2 ) initial dose of rituximab and the steroid response. Clinical outcomes were compared. Results: Data from 42 children [20 steroid-sensitive (frequent relapsing / steroid-dependent) and 22 steroid-resistant nephrotic syndrome, aged 1.9-17.3 years] were …

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Evaluation Of Seroprevalence And Clinical And Laboratory Findings Of Patients Admitted Tohealth Institutions In Gümüşhane With Suspicion Of Crimean-Congo Hemorrhagic Fever, Esra Gürbüz, Abdurrahman Eki̇ci̇, Ahmet Hakan Ünlü, Hasan Yilmaz Jan 2021

Evaluation Of Seroprevalence And Clinical And Laboratory Findings Of Patients Admitted Tohealth Institutions In Gümüşhane With Suspicion Of Crimean-Congo Hemorrhagic Fever, Esra Gürbüz, Abdurrahman Eki̇ci̇, Ahmet Hakan Ünlü, Hasan Yilmaz

Turkish Journal of Medical Sciences

Background/aim: To determine the seroprevalence and evaluate clinical findings and laboratory results of patients prediagnosed with Crimean-Congo hemorrhagic fever (CCHF) in Gümüşhane. Materials and methods: Included in the cross-sectional study were 362 patients (162 female, 200 male) between 0 and 94 years of age, who were followed up after receiving a preliminary diagnosis of CCHF between January 2011 and December 2019. Anamnesis, age, sex, clinical findings, laboratory results, epidemiological and clinical evaluations, severity criteria, risk factor reviews, and a comparison of the suspected negative cases with positive cases were analyzed retrospectively. Patients included in the study were evaluated as RNApositive …

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Investigation Of The Relationship Between Immune Checkpoints And Mismatch Repairdeficiency In Recurrent And Nonrecurrent Glioblastoma, Emel Çakir, İsmai̇l Sayğin, Mustafa Emre Erci̇n Jan 2021

Investigation Of The Relationship Between Immune Checkpoints And Mismatch Repairdeficiency In Recurrent And Nonrecurrent Glioblastoma, Emel Çakir, İsmai̇l Sayğin, Mustafa Emre Erci̇n

Turkish Journal of Medical Sciences

Background/aim: Microsatellite instability tests and programmed cell death-1 (PD-1)/programmed cell death ligand-1 (PD-L1) in the immune checkpoint pathway are the tests that determine who will benefit from immune checkpoint inhibitor therapy. We aimed to show the expression of DNA mismatch repair proteins and PD-1/PD-L1 molecules that inhibit immune checkpoints, to explain the relationship between them, and to demonstrate their predictive role in recurrent and nonrecurrent glioblastoma. Materials and methods: We analyzed 27 recurrent and 47 nonrecurrent cases at our archive. We performed immunohistochemical analysis to determine expressions of PD-1, PD-L1, and mismatch repair proteins in glioblastoma. We evaluated the relationship …

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Reference Values For T And B Lymphocyte Subpopulations In Turkish Children And Adults, Özge Besci̇, Di̇lek Başer, İsmai̇l Öğülür, Ayşe Cansu Berberoğlu, Ayça Kiykim, Tolga Besci̇, Asim Leblebi̇ci̇, Hülya Elli̇dokuz, Perran Boran, Eren Özek, Goncagül Haklar, Ahmet Oğuzhan Özen, Safa Bariş, Eli̇f Aydiner Jan 2021

Reference Values For T And B Lymphocyte Subpopulations In Turkish Children And Adults, Özge Besci̇, Di̇lek Başer, İsmai̇l Öğülür, Ayşe Cansu Berberoğlu, Ayça Kiykim, Tolga Besci̇, Asim Leblebi̇ci̇, Hülya Elli̇dokuz, Perran Boran, Eren Özek, Goncagül Haklar, Ahmet Oğuzhan Özen, Safa Bariş, Eli̇f Aydiner

Turkish Journal of Medical Sciences

Background/aim: Established reference values are critical for the interpretation of immunologic assessments. In particular, the proportion and absolute counts of T- and B- cell subpopulations are subject to change with age and ethnicity. We aimed to establish agespecific reference values for lymphocyte subsets using updated immunophenotyping panels. Materials and methods: We studied a total of 297 healthy Turkish subjects aged 0 to 50 years, stratified into major age brackets in a cluster factor of 10 per age-group. The predetermined age intervals contained randomly allocated participants enrolled over a period of 6 months, who were homogenously distributed by sex. We analyzed …

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The Relationship Between Breast Milk Intake And Speech In Children With Cerebral Palsy, Gül Demet Kaya Özçora, Gonca Bektaş Jan 2021

The Relationship Between Breast Milk Intake And Speech In Children With Cerebral Palsy, Gül Demet Kaya Özçora, Gonca Bektaş

Turkish Journal of Medical Sciences

Background/aim: Cerebral palsy (CP) is a nonprogressive neurodevelopmental disorder that cause damage to the developing brain (0-3 years) for various reasons. Children with CP commonly have speech disorders due to impairment in neuromuscular control of oro-motor coordination. We focused on the relationship between breast milk intake and speech functions in children with CP. Materials and methods: The gross motor function classification system (GMFCS) was used to categorize the gross motor function. The viking speech scale (VSS) was used to classify the speech in children with cerebral palsy. Children were subdivided into two groups as term and preterm based on gestational …

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Utilization Of Biotechnological Drugs In Rare Diseases Requiring The Use Of Off-Label Drugsin Children In Turkey, Neri̇man İpek Kirmizi, Volkan Aydin, Nari̇n Akici, Banu Bayar, Ahmet Akici Jan 2021

Utilization Of Biotechnological Drugs In Rare Diseases Requiring The Use Of Off-Label Drugsin Children In Turkey, Neri̇man İpek Kirmizi, Volkan Aydin, Nari̇n Akici, Banu Bayar, Ahmet Akici

Turkish Journal of Medical Sciences

Background/aim: Pediatric patients, especially those with rare diseases, represent a population that has a high tendency towards offlabel drug use (OLDU) and needs a more careful practice of pharmacotherapy than in adults. We aimed to investigate biotechnological drug use in children with rare diseases requiring OLDU. Materials and methods: This retrospective study examined all single-diagnosed OLDU applications (n = 5792) for 4992 children (

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Can Patients Who Apply To Tertiary Care With Headache For The First Time Be Managed Inprimary Care? - A Cross-Sectional Study, Esra Hündür Doğan, İrfan Şencan, Hasan Doğan, Adem Özkara Jan 2021

Can Patients Who Apply To Tertiary Care With Headache For The First Time Be Managed Inprimary Care? - A Cross-Sectional Study, Esra Hündür Doğan, İrfan Şencan, Hasan Doğan, Adem Özkara

Turkish Journal of Medical Sciences

Background/aim: Headaches are one of the most common neurological symptoms. They adversely affect daily life, reduces the workforce, and have high health costs. Managing this symptom in primary care will free up secondary and tertiary health services to better treat patients who need follow-up by specialists. In the present study, we aim to show the rate at which this problem can be solved in primary care for patients who applied tertiary care services with a headache for the first time. Materials and methods: Our research is a cross-sectional study of 207 patients who applied to the neurology clinics for the …

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Measurement Of Interscalene Space Volume In Diagnosis Of Thoracic Outlet Syndrome: Acadaver Study, Tevfi̇k Kaplan, Ayhan Cömert, Mehmet Ali̇ Güner, Hali̇l İbrahi̇m Açar, Gökçe Kaan Ataç, İbrahi̇m Tekdemi̇r, Serdar Han Jan 2021

Measurement Of Interscalene Space Volume In Diagnosis Of Thoracic Outlet Syndrome: Acadaver Study, Tevfi̇k Kaplan, Ayhan Cömert, Mehmet Ali̇ Güner, Hali̇l İbrahi̇m Açar, Gökçe Kaan Ataç, İbrahi̇m Tekdemi̇r, Serdar Han

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to measure the volume of interscalene space in thoracic outlet region on cadavers and radiological images and to analyze the potential value of these measurements in diagnosis and treatment of thoracic outlet syndrome (TOS). Materials and methods: The dimensions of the anterior interscalene space in 8 formalin-fixed human cadavers were studied by direct measurement and additionally evaluation of the volume of this space were done by using mold and volume calculation formula of square pyramid, due to resembling a pyramid. In the second phase of this study, interscalene space volume was calculated by …

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A Randomized Comparison Between Ultrasound-Guided Costoclavicular Andinfraclavicular Block For Upper Extremity Surgery, Sevi̇m Cesur, Ahmet Murat Yayik, Ayşe Nur Daş, Ali̇ Ahiskalioğlu Jan 2021

A Randomized Comparison Between Ultrasound-Guided Costoclavicular Andinfraclavicular Block For Upper Extremity Surgery, Sevi̇m Cesur, Ahmet Murat Yayik, Ayşe Nur Daş, Ali̇ Ahiskalioğlu

Turkish Journal of Medical Sciences

Background/aim: This study compared ultrasound guided costoclavicular (CC) and lateral sagittal infraclavicular (LS) brachial plexus block in patients undergoing upper extremity surgery. Materials and methods: A total of 80 patients undergoing upper extremity surgery were randomly classified into two groups: Group CC (costoclavicular (n = 40)) and Group LS (lateral sagittal infraclavicular (n = 40)). Both groups received a 25 mL containing a mixture of 1% lidocaine and 0.25% bupivacaine. A blinded observer recorded the block onset time and decided which patients who were admitted to the operation room needed general anesthesia or rescue block or without any iv. narcotics …

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Prognostic Value Of Oxygen Saturation And Heart Rate During A Six-Minute Walk Test Inpediatric Pulmonary Hypertension, Vi̇ldan Atasayan, Fatma Canbeyli̇, Fatma Sedef Tunaoğlu, Ayşe Deni̇z Oğuz, Bülent Çeli̇k, Serdar Kula Jan 2021

Prognostic Value Of Oxygen Saturation And Heart Rate During A Six-Minute Walk Test Inpediatric Pulmonary Hypertension, Vi̇ldan Atasayan, Fatma Canbeyli̇, Fatma Sedef Tunaoğlu, Ayşe Deni̇z Oğuz, Bülent Çeli̇k, Serdar Kula

Turkish Journal of Medical Sciences

Background/aim: To evaluate the pre and post-treatment heart rate and oxygen (O2 ) saturation values measured before, during and after 6MWT in children who received PAH-specific treatment and to determine the effect of these variables on prognosis. Materials and methods: This retrospective study included 29 patients who were diagnosed as PAH and treated. The transcutaneous O2 saturationand heart rate levels were recorded before the test: baseline (Sat0, HR0), at the end of the test: exercise (Sat1, HR1) and 5 min after the test: recovery (Sat2, HR2). The increase in heart rate was defined as HR1-HR0 and the decrease in saturation …

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Association Between Active Pulmonary Tuberculosis And Circulating Micrornas: Apreliminary Study From Turkey, Fatma Kalayci Yüksek, Cenk Kiğ, Medi̇ha Gönenç Ortaköylü, Meltem Uzun Jan 2021

Association Between Active Pulmonary Tuberculosis And Circulating Micrornas: Apreliminary Study From Turkey, Fatma Kalayci Yüksek, Cenk Kiğ, Medi̇ha Gönenç Ortaköylü, Meltem Uzun

Turkish Journal of Medical Sciences

Background/aim: Tuberculosis is a public health problem that still remains significant. For prevention, diagnosis, and treatment of tuberculosis more effective novel biomarkers are needed. MicroRNAs can regulate innate and adaptive immune responses, alter host-pathogen interactions, and affect progression of diseases. The relationship between microRNA expression and active pulmonary tuberculosis (APT) has not yet been investigated in the Turkish population. We aimed to test the potential diagnostic value of some microRNAs whose levels were previously reported to be altered in APT patients. Materials and methods: Using two different references (U6 and miR-93), we compared the expression levels of potentially important microRNAs …

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The Relationship Of Serum Visfatin Levels With Clinical Parameters, Flow-Mediateddilation, And Carotid Intima-Media Thickness In Patients With Ankylosing Spondylitis, Rabi̇a Aydoğan Baykara, Adem Küçük, Ayça Tuzcu, Göksel Tuzcu, Erkan Cüre, Ali̇ Uğur Uslu, Ahmet Omma Jan 2021

The Relationship Of Serum Visfatin Levels With Clinical Parameters, Flow-Mediateddilation, And Carotid Intima-Media Thickness In Patients With Ankylosing Spondylitis, Rabi̇a Aydoğan Baykara, Adem Küçük, Ayça Tuzcu, Göksel Tuzcu, Erkan Cüre, Ali̇ Uğur Uslu, Ahmet Omma

Turkish Journal of Medical Sciences

Background/aim: Atherosclerotic heart diseases can occur at an early age in patients with ankylosing spondylitis (AS). Flow-mediated dilation (FMD) and carotid intima-media thickness (cIMT) values are reliable markers for early detection of subclinical atherosclerosis in patients with AS. We aimed to investigate the relationship between visfatin levels and indirect markers of subclinical atherosclerosis and endothelial dysfunction in patients with AS. Materials and methods: Forty-two patients diagnosed with AS and 42 age, sex, and body mass index (BMI)-matched controls were included in the study. Visfatin levels, FMD, and cIMT were measured using appropriate methods. Results: Visfatin levels of the patients were …

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The Prevalence Of Sjögren's Syndrome And Sicca Symptoms In Patients With Systemicsclerosis And Alpha-Smooth Muscle Actin Expression In Biopsy Specimens From Minorsalivary Glands, Gerçek Can, Sülen Sarioğlu, Ahmet Meri̇h Bi̇rli̇k, Gökçe Kenar, Özgül Soysal Gündüz, Di̇lek Solmaz, Vedat Gerdan, Fatoş Önen, Nurullah Akkoç, Servet Akar Jan 2021

The Prevalence Of Sjögren's Syndrome And Sicca Symptoms In Patients With Systemicsclerosis And Alpha-Smooth Muscle Actin Expression In Biopsy Specimens From Minorsalivary Glands, Gerçek Can, Sülen Sarioğlu, Ahmet Meri̇h Bi̇rli̇k, Gökçe Kenar, Özgül Soysal Gündüz, Di̇lek Solmaz, Vedat Gerdan, Fatoş Önen, Nurullah Akkoç, Servet Akar

Turkish Journal of Medical Sciences

Background/aim: This study aimed to investigate the prevalence of sicca symptoms and secondary Sjögren's syndrome (SjS) in patients with systemic sclerosis (SSc). Also this study aimed to evaluate the expression of ∝ -smooth muscle actin (∝ -SMA) in minor salivary gland (MSG) specimens, a possible marker of fibrosis responsible for myofibroblastic transformation. Materials and methods: Patients with SSc who were followed in Rheumatology outpatient clinic at a university hospital evaluated. The questionnaire of sicca symptoms and classification of SjS were evaluated according to the American-European Consensus Group (AECG) criteria. Histopathologic evaluations were done in MSG specimens investigating the presence of …

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The Alteration Of Lymphocyte Subsets In Idiopathic Granulomatous Mastitis, Ayça Emsen, Hande Köksal, Hülya Uçaryilmaz, Nai̇m Kadoglou, Hasi̇be Artaç Jan 2021

The Alteration Of Lymphocyte Subsets In Idiopathic Granulomatous Mastitis, Ayça Emsen, Hande Köksal, Hülya Uçaryilmaz, Nai̇m Kadoglou, Hasi̇be Artaç

Turkish Journal of Medical Sciences

Background and aim: This study analyzed peripheral blood lymphocyte subsets to determine their role in the etiopathogenesis of IGM. Materials and methods: This study includes 51 pathologically proven IGM patients (active disease: 26 and in remission: 25) and 28 healthy volunteers. The analyses of lymphocyte subsets were performed by flow cytometric immunophenotyping. Results: The percentage of T helper lymphocyte of all IGM patients were lower than control groups (p = 0.001). Absolute cytotoxic T lymphocyte count (p = 0.03), both percentage (p = 0.035) and absolute count (p = 0.002) of the natural killer cells, and both percentage (p = …

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The Contribution Of Postnatal Steroid Administration To Early Brain Damage In Pretermbabies With Bronchopulmonary Dysplasia, Sabahatti̇n Ertuğrul, Savaş Mert Darakci̇, İbrahi̇m Kaplan, İlyas Yolbaş, İbrahi̇m Deger, Si̇bel Tanriverdi̇ Yilmaz, Şerafetti̇n Aktaş Jan 2021

The Contribution Of Postnatal Steroid Administration To Early Brain Damage In Pretermbabies With Bronchopulmonary Dysplasia, Sabahatti̇n Ertuğrul, Savaş Mert Darakci̇, İbrahi̇m Kaplan, İlyas Yolbaş, İbrahi̇m Deger, Si̇bel Tanriverdi̇ Yilmaz, Şerafetti̇n Aktaş

Turkish Journal of Medical Sciences

Background/aim: Postnatal corticosteroids are commonly used to treat bronchopulmonary dysplasia (BPD). We aimed to show whether S100 calcium-binding B (S100B), neuron-specific enolase (NSE), Tau protein or microtubule-associated protein tau (MAPT), and glial fibrillary acid protein (GFAP) levels would provide any evidence of early neurological damage in premature infants receiving postnatal low dose dexamethasone therapy for BPD treatment. Materials and methods: In this cohort study, 136 preterm infants diagnosed with BPD at ≤ 32 weeks of gestation formed the study group, and 64 preterm infants formed the control group. NSE, S100B, GFAP, and MAPT levels were first measured before the postnatal …

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The Relationship Between Amount Of Extra-Prostatic Extension And Length Of Capsularcontact: Performances From Mr Images And Radical Prostatectomy Specimens, Aslihan Onay Çolak, Bariş Bakir Jan 2021

The Relationship Between Amount Of Extra-Prostatic Extension And Length Of Capsularcontact: Performances From Mr Images And Radical Prostatectomy Specimens, Aslihan Onay Çolak, Bariş Bakir

Turkish Journal of Medical Sciences

Backround/aim: In prostate cancer, extraprostatic extension (EPE) is an unfavorable prognostic factor, and the grade of EPE is correlated with the prognosis. This study aims to evaluate the utility of length of capsular contact (LCC ) in predicting the grade of EPE by correlating the measurements from MRI images and the measurements performed from radical prostatectomy specimens. Materials and methods: MR images and specimens of 110 tumors are analyzed retrospectively. The specimens are used as reference to validate the presence of EPE and to measure the ground truth LCC. MR images are evaluated by two radiologists to identify the presence …

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