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Articles 192421 - 192450 of 195906
Full-Text Articles in Entire DC Network
Circumcision With Plastic Alisclamp Technique In 4733 Boys: Our Experiences To Reducecomplications, Alev Süzen, Süleyman Cüneyt Karakuş, Nazi̇le Ertürk
Circumcision With Plastic Alisclamp Technique In 4733 Boys: Our Experiences To Reducecomplications, Alev Süzen, Süleyman Cüneyt Karakuş, Nazi̇le Ertürk
Turkish Journal of Medical Sciences
Background/aim: We aim to report the outcomes of circumcisions performed with Alisclamp and our experiences to reduce the complications. Material and methods: Complications among circumcised males with Alisclamp between 2015 and 2018 were retrospectively analyzed. Patients were divided into two groups: Group 1 (n = 1429); patients circumcised in 2015-2016 and Group 2 (n = 3304); patients circumcised in 2017-2018. The different technical approaches in Group 2 are as follows: 1) Prevention of bleeding: In Group 2, we didn't pull the ventral prepuce to reduce the risk of frenulum injury and the foreskin was excised approximately 1-2 mm above the …
Retrospective Evaluation Of The Pediatric Multicystic Dysplastic Kidney Patients:Experience Of Two Centers From Southeastern Turkey, Mehtap Akbalik Kara, Aysel Taktak, Caner Alparslan
Retrospective Evaluation Of The Pediatric Multicystic Dysplastic Kidney Patients:Experience Of Two Centers From Southeastern Turkey, Mehtap Akbalik Kara, Aysel Taktak, Caner Alparslan
Turkish Journal of Medical Sciences
Background/aim: The objective of this study is to determine the clinical features of unilateral multicystic dysplastic kidney (MCDK) patients. Materials and methods: The demographic, clinical, laboratory, and radiologic features of MCDK patients at Diyarbakır Children's Hospital and Diyarbakır Gazi Yaşargil Training and Research Hospital between January 2008-June 2019 were retrospectively evaluated. Results: A total of 111 [59 (53.2%) male and 52(46.8%) female] patients with MCDK were followed for a mean period of 41.89 ± 32.03 months. MCDK was located on the left and right sides in 46 (41.4%) and 65 (58.6%) of the children, respectively (p > 0.05). A total of …
Prone Versus Barts "Flank-Free" Modified Supine Percutaneous Nephrolithotomy: Amatch-Pair Analysis, Uygar Mi̇çooğullari, Davut Kamaci, Mehmet Yildizhan, Furkan Umut Kiliç, Taha Çeti̇n, Özer Ural Çakici, Murat Keske, Mehmet Yi̇ği̇t Yalçin, Arslan Ardiçoğlu
Prone Versus Barts "Flank-Free" Modified Supine Percutaneous Nephrolithotomy: Amatch-Pair Analysis, Uygar Mi̇çooğullari, Davut Kamaci, Mehmet Yildizhan, Furkan Umut Kiliç, Taha Çeti̇n, Özer Ural Çakici, Murat Keske, Mehmet Yi̇ği̇t Yalçin, Arslan Ardiçoğlu
Turkish Journal of Medical Sciences
Background/aim: In this study, we aimed to compare the results of prone and Barts "flank-free" modified supine percutaneous nephrolithotomy (PCNL) operations in our clinic. Materials and methods: The data from patients that underwent Barts "flank-free" modified supine PCNL (BS-PCNL) (n = 52) between June 2018 and July 2020 and prone PCNL (P-PCNL) (n = 286) between April 2014 and June 2018 were retrospectively evaluated. Of those 286 patients, 104 patients whose sex, age, body mass index, American Society of Anesthesiology score, stone localization, stone size, and hydronephrosis matched the BS-PCNL group in a 1:2 ratio were included in the study. …
Comparison Of Frozen-Thawed Embryo Transfer Protocols In Patients With Previouscycle Cancellation Due To Uterine Peristalsis: A Pilot Study, İlknur Selvi̇, Mehmet Erdem, Erhan Demi̇rdağ, Müni̇re Funda Cevher Akdulum, Cengi̇z Karakaya, Ahmet Erdem
Comparison Of Frozen-Thawed Embryo Transfer Protocols In Patients With Previouscycle Cancellation Due To Uterine Peristalsis: A Pilot Study, İlknur Selvi̇, Mehmet Erdem, Erhan Demi̇rdağ, Müni̇re Funda Cevher Akdulum, Cengi̇z Karakaya, Ahmet Erdem
Turkish Journal of Medical Sciences
Background/aim: To investigate the optimal protocol for frozen-thawed embryo transfer (FET) cycles in patients who previously had a cycle cancellation due to uterine peristalsis (UP). Materials and methods: Thirty-four patients with previous embryo transfer (ET) cancellation due to UP during artificial cycle (AC) were included retrospectively. In the proceeding cycle, endometrium was prepared with AC (n: 23) in AC-FET group or with stimulated cycle that contains letrozole (L) (n: 11) in L-FET group. Intravenous bolus dose of 6.75 mg atosiban (Tractocile; Ferring Pharmaceuticals, Switzerland) injection was performed to all patients of AC-FET group due to UP ≥ 4/min on the …
The Effect Of Weather Variables On The Severity, Duration, And Frequency Of Headacheattacks In The Cases Of Episodic Migraine And Episodic Tension-Type Headache, Nergi̇s Akgün, Esra Aciman Demi̇rel, Mustafa Açikgöz, Ulufer Çelebi̇, Fürüzan Köktürk, Hüseyi̇n Tuğrul Atasoy
The Effect Of Weather Variables On The Severity, Duration, And Frequency Of Headacheattacks In The Cases Of Episodic Migraine And Episodic Tension-Type Headache, Nergi̇s Akgün, Esra Aciman Demi̇rel, Mustafa Açikgöz, Ulufer Çelebi̇, Fürüzan Köktürk, Hüseyi̇n Tuğrul Atasoy
Turkish Journal of Medical Sciences
Background/aim: Although many headache patients report that the frequency and severity of attacks vary according to the season or weather in clinical practice, the relationship between the characteristics of the attacks and the weather is not very clear in episodic headaches. We aimed to compare the effects of weather variables (temperature, wind speed, wind direction, humidity, pressure, ultraviolet index, and sunshine duration) on episodic migraine (EM) and episodic tension-type headache (ETTH) attacks (incidence, duration, and severity). Materials and methods: Fifty patients with EM and fifty patients with ETTH diagnosed according to International Classification of Headache Disorders-II are included in the …
An Investigation Of The Factors That Influence Functional Improvement In Strokerehabilitation, Onur Altuntaş, Serkan Taş, Alp Çeti̇n
An Investigation Of The Factors That Influence Functional Improvement In Strokerehabilitation, Onur Altuntaş, Serkan Taş, Alp Çeti̇n
Turkish Journal of Medical Sciences
Background/aim: The purpose of this study was to determine effect of age, sex, affected extremity, disability severity, treatment type, cerebrovascular accident (CVA) etiology, number of treatment sessions, and CVA duration on the functional improvement of the stroke patients who participated in a physical medicine and rehabilitation program. Materials and methods: The research sample consisted of 322 stroke patients. Clinical and demographic features including age, sex, affected extremity, disability severity, treatment type, CVA etiology, number of treatment sessions, and CVA duration were recorded. Functional status was evaluated retrospectively by using the functional independence measure (FIM) at admission and discharge. Results: It …
The Assessment Of The Effect Of Different Intraabdominal Pressures Used For Laparoscopiccholecystectomy Surgery On Optic Nerve Sheath Diameter: A Prospective Observationalcohort Study, Tuna Ertürk, Bülent Bariş Güven, Yadi̇gar Yilmaz Camgöz, Fulya Yurtsever, Ayşin Ersoy
The Assessment Of The Effect Of Different Intraabdominal Pressures Used For Laparoscopiccholecystectomy Surgery On Optic Nerve Sheath Diameter: A Prospective Observationalcohort Study, Tuna Ertürk, Bülent Bariş Güven, Yadi̇gar Yilmaz Camgöz, Fulya Yurtsever, Ayşin Ersoy
Turkish Journal of Medical Sciences
Background/aim: During laparoscopic cholecystectomy operations, increases in intraabdominal, intrathoracic, and intracranial pressures (ICP) can be seen after pneumoperitoneum created for surgical imaging. Orbital ultrasonography (USG), which has been developed in recent years, is a method that can evaluate the ICP by measuring the optic nerve sheath diameter (ONSD) from the eyeball. In our study, we aimed to evaluate whether different intraabdominal pressure values created during laparoscopic cholecystectomy operations correlate with ICP by measuring ONSD. Materials and methods: The study included a total of 90 patients with American Society of Anesthesiologists (ASA) physical status classification I (ASA I) and II (ASA …
Effect Of Vitamin D Supplementation On Lower Extremity Motor Function And Ambulationin Stroke Patients, Ayça Utkan Karasu, Gülçi̇n Kaymak Karataş
Effect Of Vitamin D Supplementation On Lower Extremity Motor Function And Ambulationin Stroke Patients, Ayça Utkan Karasu, Gülçi̇n Kaymak Karataş
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to investigate the effect of vitamin D supplementation on ambulation and mobility in hospitalized patients undergoing stroke rehabilitation. Materials and methods: This study was conducted retrospectively between September 2020 and October 2020 at Gazi University Faculty of Medicine Physical Medicine and Rehabilitation Department. Seventy-six patients who received inpatient stroke rehabilitation treatment between May 2018 and February 2020 were included in the study. The patients were divided into two groups as those who did and did not take vitamin D supplements. Lower extremity motor function and ambulation status were compared using Brunnstrom recovery stage …
Can Pre-Procedural Mri Signal Intensity Ratio Predict The Success Of Uterine Arteryembolization In Treatment Of Myomas?, Çağlayan Çakir, Fati̇h Kilinç, Muhammed Aki̇f Deni̇z, Sema Karakaş
Can Pre-Procedural Mri Signal Intensity Ratio Predict The Success Of Uterine Arteryembolization In Treatment Of Myomas?, Çağlayan Çakir, Fati̇h Kilinç, Muhammed Aki̇f Deni̇z, Sema Karakaş
Turkish Journal of Medical Sciences
Background/aim: Magnetic resonance (MR) images, signal intensity ratios calculated using region of interests (ROI) in T2W images by proportioning the dominant myoma to iliac muscle can aid patient selection and, thus, in achieving better outcomes with the uterine artery embolization (UAE) procedure. The present study investigates the association between the success of UAE treatment with signal intensity (SI) ratio of the dominant myoma to the iliac muscle in MR imaging performed prior to the procedure. Materials and methods: This is a retrospective study and included 30 patients who admitted to our clinic between February 2017 and July 2019 due to …
Evaluation Of S100a12 Protein Levels In Children With Familial Mediterranean Fever, Yelda Türkmenoğlu, Eli̇f Güney, Di̇ğdem Bezen, Ahmet İrdem, Bi̇ray Ertürk, Hasan Dursun
Evaluation Of S100a12 Protein Levels In Children With Familial Mediterranean Fever, Yelda Türkmenoğlu, Eli̇f Güney, Di̇ğdem Bezen, Ahmet İrdem, Bi̇ray Ertürk, Hasan Dursun
Turkish Journal of Medical Sciences
Background/aim: Familial Mediterranean fever (FMF), the most common autoinflammatory disease in children, is characterized by recurrent febrile episodes. FMF is known to progress with chronic inflammation, particularly during attack periods. This study aimed to investigate the relationship of S100A12, an inflammatory marker, with attacks and inflammatory events in FMF patients. Materials and methods: The study included 57 patients diagnosed with FMF, 43 in an attack-free period and 14 in an attack period, and 31 healthy children as the control group. Only white blood cell (WBC) count, C-reactive protein (CRP) level, erythrocyte sedimentation rate (ESR), and S100A12 level were analyzed in …
Sequential Analysis Of Single-Center Experience Of Living Donor Kidney Transplants Withseveral Vascular Anastomosis Techniques, Berri̇n Papi̇la Kundaktepe, Ali̇ Vedat Durgun, Ertuğrul Göksoy, Sali̇h Pekmezci̇, Meti̇n Kapan, Kaya Saribeyoğlu, Mehmet Veli̇dedeoğlu, Mehmet Eli̇çevi̇k
Sequential Analysis Of Single-Center Experience Of Living Donor Kidney Transplants Withseveral Vascular Anastomosis Techniques, Berri̇n Papi̇la Kundaktepe, Ali̇ Vedat Durgun, Ertuğrul Göksoy, Sali̇h Pekmezci̇, Meti̇n Kapan, Kaya Saribeyoğlu, Mehmet Veli̇dedeoğlu, Mehmet Eli̇çevi̇k
Turkish Journal of Medical Sciences
Background and aim: Vascular variations of grafts are handled with various reconstruction techniques in renal transplantation. We aimed to analyze the effects of these reconstruction techniques and sites on patient/graft outcomes. Materials and methods: Renal transplantation cases at the Transplantation Unit of the General Surgery Department, İstanbul University Cerrahpaşa Medical Faculty between January 1st, 2000 and December 31st, 2012 were analyzed retrospectively. Postoperative duplex ultrasound results, urea-creatinine reduction rates, and complications were evaluated. Results: There were 228 living-donor transplantation cases evaluated. For single-renal-artery living-donor transplantations, there were 45 end-to-side external iliac artery, 15 end-to-side internal iliac artery, 152 end-to-end internal …
Detection Of Helicobacter Pylori By Invasive Tests In Adult Dyspeptic Patientsand Antibacterial Resistance To Six Antibiotics, Including Rifampicin In Turkey. Isclarithromycin Resistance Rate Decreasing?, Mustafa Akar, Fuat Aydin, Tuba Kayman, Seçi̇l Abay, Emre Karakaya
Detection Of Helicobacter Pylori By Invasive Tests In Adult Dyspeptic Patientsand Antibacterial Resistance To Six Antibiotics, Including Rifampicin In Turkey. Isclarithromycin Resistance Rate Decreasing?, Mustafa Akar, Fuat Aydin, Tuba Kayman, Seçi̇l Abay, Emre Karakaya
Turkish Journal of Medical Sciences
Background/aim: The prevalence of Helicobacter pylori is reported to be roughly 80% in Turkey, and only very few culture-based studies are available on antibacterial resistance in adult dyspeptic patients. This study was carried out in adult dyspeptic patients with an aim to: (i) detect H. pylori by invasive tests (culture, polymerase chain reaction, and histopathology) and (ii) determine the current resistance rates of H. pylori isolates to six antibiotics, including rifampicin. Materials and methods: This study was conducted in 422 adult dyspeptic patients. The presence of H. pylori was demonstrated by culture, polymerase chain reaction, and the histopathology of gastric …
Impact Of Fetal Brain Tissue Derived Mesenchymal Stem Cell And Fibrin Glue On Facial Nervecrash Injury, Ömer Bayir, Tuğba Karagöz, Ferda Alpaslan Pinarli, Güli̇stan Sanem Saribaş, Candan Özoğul, Kemal Keseroğlu, Güleser Saylam, Emel Çadalli Tatar, Sevi̇lay Karahan, Bülent Öcal, Mehmet Hakan Korkmaz
Impact Of Fetal Brain Tissue Derived Mesenchymal Stem Cell And Fibrin Glue On Facial Nervecrash Injury, Ömer Bayir, Tuğba Karagöz, Ferda Alpaslan Pinarli, Güli̇stan Sanem Saribaş, Candan Özoğul, Kemal Keseroğlu, Güleser Saylam, Emel Çadalli Tatar, Sevi̇lay Karahan, Bülent Öcal, Mehmet Hakan Korkmaz
Turkish Journal of Medical Sciences
Background/aim: To evaluate the clinical and histopathological effects of fetal brain tissue derived mesenchymal stem cells (FBTMSC) and fibrin glue (FG) on the facial nerve (FN) regeneration in rats with traumatic FN injury. Materials and methods: Twenty-eight Sprague Dawley rats were included in the study and divided into 4 groups. Traumatic FN injury (FP) was created by a surgical clamp compression to the main trunk of left FN in all groups. In the control group (group 1) no treatment was applied, in group 2 (FBTMSC group) 2 × 106 FBTMSC was injected, in group 3 (FG group) only FG was …
The Effect Of Testosterone Replacement Therapy On Bladder Functions, Histology, Apoptosis,And Rho-Kinase Expression In Bladder Outlet Obstruction And Hypogonadism Rat Model, Bariş Saylam, Ozan Efesoy, Rabi̇a Bozdoğan Arpaci, Ruki̇ye Nalan Ti̇fti̇k, Mesut Tek, Kansu Büyükafşar, Murat Bozlu, Selahi̇tti̇n Çayan
The Effect Of Testosterone Replacement Therapy On Bladder Functions, Histology, Apoptosis,And Rho-Kinase Expression In Bladder Outlet Obstruction And Hypogonadism Rat Model, Bariş Saylam, Ozan Efesoy, Rabi̇a Bozdoğan Arpaci, Ruki̇ye Nalan Ti̇fti̇k, Mesut Tek, Kansu Büyükafşar, Murat Bozlu, Selahi̇tti̇n Çayan
Turkish Journal of Medical Sciences
Background/aim: The effect of testosterone replacement therapy was investigated on bladder functions, histology, apoptosis as well as Rho-kinase expression in the rat bladder outlet obstruction (BOO) and hypogonadism models. Materials and methods: 30 mature male rats divided into 4 groups: sham group (n = 8), BOO group (n = 8), BOO + orchiectomy group (n = 7), BOO + orchiectomy + testosterone (T) treatment group (n = 7). Cystometric findings, apoptosis index, Rho-kinase (ROCK-2) expression, and smooth muscle/collagen ratio were compared. Results: BOO did not change ROCK-2 expression level, compared to sham group (P > 0.05). However, when compared to BOO …
Investigation Of The Effect Of Hyperthyroidism On Endoplasmic Reticulum Stress And Transient Receptor Potential Canonical 1 Channel In The Kidney, Nuri̇ye Ezgi̇ Bektur, Erhan Şahi̇n, Sedat Kaçar, Ridvan Bağci, Şeri̇fe Karakaya, Di̇lek Burukoğlu Dönmez, Varol Şahi̇ntürk
Investigation Of The Effect Of Hyperthyroidism On Endoplasmic Reticulum Stress And Transient Receptor Potential Canonical 1 Channel In The Kidney, Nuri̇ye Ezgi̇ Bektur, Erhan Şahi̇n, Sedat Kaçar, Ridvan Bağci, Şeri̇fe Karakaya, Di̇lek Burukoğlu Dönmez, Varol Şahi̇ntürk
Turkish Journal of Medical Sciences
Background/aim: Hyperthyroidism is associated with results in increased glomerular filtration rate as well as increased renin-angiotensin-aldosterone activation. The disturbance of Ca2+ homeostasis in the endoplasmic reticulum (ER) is associated with many diseases, including diabetic nephropathy and hyperthyroidism. Transient receptor potential canonical 1 (TRPC1) channel is the first cloned TRPC family protein. Although it is expressed in many places in the kidney, its function is uncertain. TRPC1 is involved in regulating Ca2+ homeostasis, and its upregulation increases ER Ca2+ level, activates the unfolded protein response, which leads to cellular damage in the kidney. This study investigated the role of TRPC1 in …
Contribution Of Amniotic Membrane To The Healing Of Iatrogenic Vas Deferens Injury, Sabri̇ Demi̇r, Ahmet Ertürk, Mehmet Zengi̇n, Di̇nçer Yildiz, Si̇yami̇ Karahan, Emrah Şenel
Contribution Of Amniotic Membrane To The Healing Of Iatrogenic Vas Deferens Injury, Sabri̇ Demi̇r, Ahmet Ertürk, Mehmet Zengi̇n, Di̇nçer Yildiz, Si̇yami̇ Karahan, Emrah Şenel
Turkish Journal of Medical Sciences
Background/aim: Iatrogenic vas deferens injury is one of the most serious complications of operations in the inguinal region. Vasovasostomy is performed as treatment. However, stenosis is common after vasovasostomy. Oligospermia or azoospermia may develop and result in infertility. This study aimed to investigate the effect of amniotic membrane on healing in vas deferens injuries. Materials and methods: Four groups consisting of 10 rats each were formed. No procedure was performed in Group-I. In GroupII, the left vas deferens was transected and left to spontaneous healing. In Group-III, the left vas deferens was transected, and endto-end anastomosis was performed. In Group-IV, …
Protective And Therapeutic Effect Of Hydrogen Sulfide On Hemorrhagic Cystitis And Testisdysfunction Induced With Cyclophosphamide, Fi̇kri̇ye Yasemi̇n Özati̇k, Orhan Özati̇k, Yasemi̇n Tekşen, Semra Yi̇ği̇taslan, Nezi̇ha Senem Ari
Protective And Therapeutic Effect Of Hydrogen Sulfide On Hemorrhagic Cystitis And Testisdysfunction Induced With Cyclophosphamide, Fi̇kri̇ye Yasemi̇n Özati̇k, Orhan Özati̇k, Yasemi̇n Tekşen, Semra Yi̇ği̇taslan, Nezi̇ha Senem Ari
Turkish Journal of Medical Sciences
Backround/aim: Cyclophosphamide (CP) is a drug used for treatment of many malignant diseases. However, it can cause serious side effects such as hemorrhagic cystitis and male infertility. Hydrogen sulfide (H2 S) is a gaseous mediator and is suggested to have antioxidant, antiinflammatory, and antiapoptotic effects. In this study, dose-dependent effects of H2 S donor sodium hydrosulfide (NaHS) on cyclophosphamide-induced hemorrhagic cystitis and testicular dysfunction were investigated in rats. Material and methods: Rats were divided into 5 groups (n = 8): control, CP, NaHS25 μmol/kg, NaHS50 μmol/kg, and NaHS100 μmol/ kg. After treatment for 7 days intraperitoneally (ip), a single ip …
Sodium Valproate Improves Sensorimotor Gating Deficit Induced By Sleep Deprivation Atlow Doses, Muhammet Teki̇n, Fatma Duygu Kaya Yertutanol, Burcu Çevreli̇, Asi̇l Ali̇ Özdoğru, Hamza Kulaksiz, İsmai̇l Tayfun Uzbay
Sodium Valproate Improves Sensorimotor Gating Deficit Induced By Sleep Deprivation Atlow Doses, Muhammet Teki̇n, Fatma Duygu Kaya Yertutanol, Burcu Çevreli̇, Asi̇l Ali̇ Özdoğru, Hamza Kulaksiz, İsmai̇l Tayfun Uzbay
Turkish Journal of Medical Sciences
Background/aim: Sleep deprivation disrupts prepulse inhibition of acoustic startle reflex and can be used to mimic psychosis in experimental animals. On the other hand, it is also a model for other disorders of sensory processing, including migraine. This study aims to assess the effects of sodium valproate, a drug that is used in a variety of neuropsychiatric disorders, on normal and disrupted sensorimotor gating in rats. Materials and methods: Sixty-two Wistar albino rats were randomly distributed into 8 groups. Subchronic and intraperitoneal sodium valproate were administrated to the sleep-deprived and nonsleep-deprived rats by either 50-100 or 200 mg/kg/day. Prepulse inhibition …
Potential Antidiabetic Activity Of Benzimidazole Derivative Albendazole And Lansoprazoledrugs In Different Doses In Experimental Type 2 Diabetic Rats, Burak Di̇k, Devran Coşkun, Emre Bahçi̇van, Kami̇l Üney
Potential Antidiabetic Activity Of Benzimidazole Derivative Albendazole And Lansoprazoledrugs In Different Doses In Experimental Type 2 Diabetic Rats, Burak Di̇k, Devran Coşkun, Emre Bahçi̇van, Kami̇l Üney
Turkish Journal of Medical Sciences
Aim: The aim of this study is to determine the effects of different concentrations of albendazole and lansoprazole, which were benzimidazole derivatives, on endocrinologic and biochemical parameters in experimental type 2 diabetic (T2D) rats. Materials and methods: In this study, 46 male Wistar Albino rats were used. Animals were divided as healthy control (0.1 mL/rat/day saline, s.c, n = 6), diabetes control (0.1 mL/rat/day saline, s.c, n = 8), diabetes+low-dose albendazole (5 mg/kg, oral, n = 8), diabetes+highdose albendazole (10 mg/kg, oral n = 8), diabetes+low-dose lansoprazole (15 mg/kg, subcutaneous, n = 8), and diabetes+high-dose lansoprazole (30 mg/kg, subcutaneous, n …
The Effect Of 1,25-Dihydroxyvitamin D3 On Liver Damage, Oxidative Stress, And Advanced Glycation End Products In Experimental Nonalcoholicand Alcoholic- Fatty Liver Disease, İlknur Bi̇ngül, Abdurrahman Fati̇h Aydin, Canan Küçükgergi̇n, Asi̇ye Işin Doğan Eki̇ci̇, Semra Abbasoğlu, Mehmet Müjdat Uysal
The Effect Of 1,25-Dihydroxyvitamin D3 On Liver Damage, Oxidative Stress, And Advanced Glycation End Products In Experimental Nonalcoholicand Alcoholic- Fatty Liver Disease, İlknur Bi̇ngül, Abdurrahman Fati̇h Aydin, Canan Küçükgergi̇n, Asi̇ye Işin Doğan Eki̇ci̇, Semra Abbasoğlu, Mehmet Müjdat Uysal
Turkish Journal of Medical Sciences
Background/aim: Oxidative stress and advanced glycation end products (AGEs) formation are proposed as effective mechanisms in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD). 1,25(OH)2 D3 was proposed to have antioxidant, antiinflammatory and antiglycation properties. In this study, the effect of 1,25(OH)2 D3 treatment on oxidative stress parameters and AGEs levels together with hepatic histopathology was investigated in high fructose (HFr) or ethanol (EtOH)-treated rats. Materials and methods: Rats were treated with fructose (30%) or ethanol (5-20%) in drinking water with and without 1,25(OH)2 D3 treatment (5 µg/kg two times a week) for 8 weeks. …
What Is The Main Factor In Predicting The Morbidity And Mortality In Patients Withgastroschisis: Delivery Time, Delivery Mode, Closure Method, Or The Type Of Gastroschisis(Simple Or Complex)?, Mustafa Behram, Süleyman Cemi̇l Oğlak, Seyi̇than Özaydin, Sema Süzen Çaypinar, İlker Gönen, Şeyhmus Tunç, Yusuf Başkiran, İsmai̇l Özdemi̇r
What Is The Main Factor In Predicting The Morbidity And Mortality In Patients Withgastroschisis: Delivery Time, Delivery Mode, Closure Method, Or The Type Of Gastroschisis(Simple Or Complex)?, Mustafa Behram, Süleyman Cemi̇l Oğlak, Seyi̇than Özaydin, Sema Süzen Çaypinar, İlker Gönen, Şeyhmus Tunç, Yusuf Başkiran, İsmai̇l Özdemi̇r
Turkish Journal of Medical Sciences
Background/aim: There are numerous debates in the management of gastroschisis (GS). The current study aimed to evaluate perinatal outcomes and surgical and clinical characteristics among GS patients based on their type of GS, abdominal wall closure method, and delivery timing. Materials and methods: This study was a retrospective analysis of prospectively collected data of 29 fetuses with GS that were prenatally diagnosed, delivered, and managed between June 2015 and December 2019 at the Obstetrics and Pediatric Surgery Clinics of Kanuni Sultan Süleyman Training and Research Hospital. Results: Twenty-three of the patients had simple GS, and six of them had complex …
The Histopathological Effects Of Reabsorbable Polyethylene Glycol Hydrogel (Coseal) Onepidural Fibrosis In An Experimental Postlaminectomy Model In Rats, Emrah Keski̇n, Hasan Ali̇ Aydin, Murat Kalayci, Emre Işik, Utku Özgen, Kenan Şi̇mşek, Deni̇z Baklaci, Mertol Gökçe
The Histopathological Effects Of Reabsorbable Polyethylene Glycol Hydrogel (Coseal) Onepidural Fibrosis In An Experimental Postlaminectomy Model In Rats, Emrah Keski̇n, Hasan Ali̇ Aydin, Murat Kalayci, Emre Işik, Utku Özgen, Kenan Şi̇mşek, Deni̇z Baklaci, Mertol Gökçe
Turkish Journal of Medical Sciences
Background/aim: To investigate the histopathological effects of reabsorbable polyethylene glycol hydrogel (RPGH, Coseal) on epidural fibrosis (EF) following laminectomy in rats. Materials and methods: A total of 24 rats were equally divided into three groups. In the first group, no treatment was applied after laminectomy (control group, Group 1). In the second group, hemostasis was achieved after laminectomy, and 2 mm absorbable gelatin sponge soaked in saline was placed over the epidural space and the wound was closed (Group 2). In the third group, hemostasis was achieved following laminectomy, and 0.5 mL RPGH (Coseal, Group 3) was squeezed over the …
Hyperbaric Oxygen Therapy Affects Insulin Sensitivity/Resistance By Increasingadiponectin, Resistin, And Plasminogen Activator Inhibitor-I In Rats, Cemi̇l Kahraman, Hüseyi̇n Yaman
Hyperbaric Oxygen Therapy Affects Insulin Sensitivity/Resistance By Increasingadiponectin, Resistin, And Plasminogen Activator Inhibitor-I In Rats, Cemi̇l Kahraman, Hüseyi̇n Yaman
Turkish Journal of Medical Sciences
Background/aim: Hyperbaric oxygen therapy (HBOT) causes insulin sensitivity, but the reason for this is not known yet. The aim of the present study was to investigate the effect of HBOT on insulin sensitivity via resistin, plasminogen activator inhibitor-I (PAI-I), and adiponectin. Materials and methods: The study was designed using HBOT and control groups, with eight rats in each group. After 20 days of HBOT under 2.5 atmospheres for 90 min, the fasting insulin (FI), resistin, PAI-I, homeostatic model assessment of insulin resistance scores (HOMA-IR), quantitative insulin sensitivity check index (QUICKI), fasting plasma glucose (FPG), triglyceride, and high-density lipoprotein cholesterol (HDL-C) …
Two Separate And Important Points That Should Not Be Forgotten Among The Consequencesof The Pandemic: Psychology Of Healthcare Workers And Readmission Of Dischargedcovid-19 Patients, Oğuz Abdullah Uyaroğlu
Two Separate And Important Points That Should Not Be Forgotten Among The Consequencesof The Pandemic: Psychology Of Healthcare Workers And Readmission Of Dischargedcovid-19 Patients, Oğuz Abdullah Uyaroğlu
Turkish Journal of Medical Sciences
No abstract provided.
Sars-Cov-2 Associated Rhabdomyolysis In 32 Patients, Josef Finsterer, Fulvio Scorza
Sars-Cov-2 Associated Rhabdomyolysis In 32 Patients, Josef Finsterer, Fulvio Scorza
Turkish Journal of Medical Sciences
Background/aim: This mini-review aims at summarising and discussing previous and recent findings concerning the clinical manifestations, therapeutic management, and outcome of SARS-CoV-2 associated rhabdomyolysis. Materials and methods: Literature search in the PubMed database by applying appropriate search terms. Results: A total of 26 articles reporting SARS-CoV-2 associated rhabdomyolysis in 32 patients were identified. Age ranged from 16 to 80 years. Four patients were female and 25 were male. Onset of rhabdomyolysis was prior to onset of COVID-19 in 7 patients, and after onset of COVID-19 in the remaining patients. Exposure to myotoxic medication was identified in 18 patients. Myotoxic drugs …
Preferences Of Inflammatory Arthritis Patients For Biological Disease-Modifyingantirheumatic Drugs In The First 100 Days Of The Covid-19 Pandemic, Umut Kalyoncu, Yavuz Pehli̇van, Servet Akar, Ti̇muçi̇n Kaşi̇foğlu, Gezmi̇ş Ki̇myon, Ömer Karadağ, Hüseyi̇n Edi̇z Dalkiliç, Ali̇ İhsan Ertenli̇, Levent Kiliç, Emi̇ne Duygu Ersözlü, Cemal Bes, Hakan Emmungi̇l, Ridvan Mercan, Eli̇f Edi̇boğlu, Ni̇lüfer Alpay Kanitez
Preferences Of Inflammatory Arthritis Patients For Biological Disease-Modifyingantirheumatic Drugs In The First 100 Days Of The Covid-19 Pandemic, Umut Kalyoncu, Yavuz Pehli̇van, Servet Akar, Ti̇muçi̇n Kaşi̇foğlu, Gezmi̇ş Ki̇myon, Ömer Karadağ, Hüseyi̇n Edi̇z Dalkiliç, Ali̇ İhsan Ertenli̇, Levent Kiliç, Emi̇ne Duygu Ersözlü, Cemal Bes, Hakan Emmungi̇l, Ridvan Mercan, Eli̇f Edi̇boğlu, Ni̇lüfer Alpay Kanitez
Turkish Journal of Medical Sciences
Background/aim: To evaluate treatment adherence and predictors of drug discontinuation among patients with inflammatory arthritis receiving bDMARDs within the first 100 days after the announcement of the COVID-19 pandemic. Materials and methods: A total of 1871 patients recorded in TReasure registry for whom advanced therapy was prescribed for rheumatoid arthritis (RA) or spondyloarthritis (SpA) within the 3 months (6-9 months for rituximab) before the declaration of COVID-19 pandemic were evaluated, and 1394 (74.5%) responded to the phone survey. Patients' data regarding demographic, clinical characteristics and disease activity before the pandemic were recorded. The patients were inquired about the diagnosis of …
The Comparison Of Favipiravir And Lopinavir/Ritonavir Combination In Covid-19treatment, Hali̇t Çinarka, Gülşah Günlüoğlu, Mustafa Çörtük, Si̇bel Yurt, Murat Kiyik, Ayşe Fi̇li̇z Koşar, Eli̇f Tanriverdi̇, Meli̇h Akay Arslan, Kürşad Nuri̇ Baydi̇li̇, Aysu Si̇nem Koç, Sedat Altin, Erdoğan Çeti̇nkaya
The Comparison Of Favipiravir And Lopinavir/Ritonavir Combination In Covid-19treatment, Hali̇t Çinarka, Gülşah Günlüoğlu, Mustafa Çörtük, Si̇bel Yurt, Murat Kiyik, Ayşe Fi̇li̇z Koşar, Eli̇f Tanriverdi̇, Meli̇h Akay Arslan, Kürşad Nuri̇ Baydi̇li̇, Aysu Si̇nem Koç, Sedat Altin, Erdoğan Çeti̇nkaya
Turkish Journal of Medical Sciences
Background/aim: SARS-CoV-2, a ribonucleic acid coronavirus, rapidly spread worldwide within a short timeframe. Although different antiviral, antiinflammatory, and immunomodulatory drugs are used, current evidence is insufficient as to which drug is more efficient. Our study compared favipiravir and lopinavir/ritonavir (LPV/RTV) therapies in inpatient care for coronavirus disease 2019 (COVID-19) pneumonia. Materials and methods: Demographic data, test results, treatments, and latest status of patients receiving inpatient COVID-19 pneumonia therapy were recorded. The initial favipiravir and LPV/RTV receiving groups were compared regarding the need for intensive care units (ICU) and mortality. Logistic regression analysis was performed by including variables showing significant differences …
Impact Of Covid-19 On Serum Melatonin Levels And Sleep Parameters In Children, Özlem Yayici Köken, Pembe Gültutan, Merve Si̇bel Güngören, Gülsüm İclal Bayhan, Deni̇z Yilmaz, Esra Gürkaş, Hami̇t Özyürek, Ayşegül Neşe Çitak Kurt
Impact Of Covid-19 On Serum Melatonin Levels And Sleep Parameters In Children, Özlem Yayici Köken, Pembe Gültutan, Merve Si̇bel Güngören, Gülsüm İclal Bayhan, Deni̇z Yilmaz, Esra Gürkaş, Hami̇t Özyürek, Ayşegül Neşe Çitak Kurt
Turkish Journal of Medical Sciences
Background/aim: This study aimed to analyze the serum melatonin levels and changes in sleep patterns in pediatric patients with coronavirus disease 2019 (COVID-19). Materials and methods: This study was designed as a descriptive, cross-sectional study. Serum melatonin levels and sleep parameters of children with the diagnosis of COVID-19 who had mild and moderate disease (i.e., COVID-19 group) were compared with those of children admitted with non-COVID-19 nonspecific upper respiratory tract infection (i.e., control group). The sleep disturbance scale for children (SDSC) questionnaire was applied to the participants' primary caregivers to analyze their sleep patterns at present and six months before …
Autoimmunity In Psoriatic Arthritis: Pathophysiological And Clinical Aspects, Hakan Emmungi̇l, Ufuk İlgen, Rafi̇ Haner Di̇reskeneli̇
Autoimmunity In Psoriatic Arthritis: Pathophysiological And Clinical Aspects, Hakan Emmungi̇l, Ufuk İlgen, Rafi̇ Haner Di̇reskeneli̇
Turkish Journal of Medical Sciences
Psoriatic arthritis (PsA) is an underdiagnosed entity with a broad impact on the quality of life. Although the pathogenesis is largely unknown, autoimmune footprints of the inflammation in PsA have increasingly been recognized. Most of the genetic variation predisposing to PsA is mapped to the class I major histocompatibility complex (MHC) region and shared by a variety of autoimmune diseases. Polymorphisms in the genes IL12B, IL23R, IL13, TNIP1, TRAF3IP2, TYK2, and many others explain the nonHLA genetic risk with little known functional consequences. Entheseal and synovial cellular infiltrate with oligoclonal CD8+ T cells and occasional germinal centers, loss of regulatory …