Digital Commons Network^™

Hospital Librarianship: What’S The New Normal?, Seema Bhakta

Articles, Abstracts, and Reports

No abstract provided.

Maternal Social Support, Depression And Emotional Availability In Early Mother-Infant Interaction: Findings From A Pregnancy Cohort, Kelli K. Macmillan, Andrew J. Lewis, Stuart J. Watson, Declan Bourke, Megan Galbally

Nursing Papers and Journal Articles

Background: Social support theory suggests that parental social support may influence the nature of early parenting behaviours and specifically the mother-infant relationship. This study examines whether support from a partner, friends or family is associated with differences in quality of mother-infant interactions in the context of maternal depression.

Methods: 210 women were followed from early pregnancy to six months postpartum within Australian pregnancy cohort, the Mercy Pregnancy and Emotional Wellbeing Study (MPEWS). Mother-infant interactions within a standardised observation at six months postpartum were measured by the Emotional Availability (EA) Scales using total scores of the parental scales. In early and …

Infant Removal From Birth Parents - How Does Health Information Impact Court Decisions? A Scoping Review, Rachel Gregory-Wilson, Liesel Spencer, Elizabeth Handsley, Toby Raeburn

Nursing Papers and Journal Articles

Problem: Courts make complex decisions daily regarding removal of infants from birth parents and placement in out-of-home care. Nurses and other health professionals often take part in such processes, either as court informants, witnesses, or via their role delivering healthcare to infants and/or birth parents involved. To date there has been very little research exploring how health information impacts upon decision-making about infant removal.

Aim: To explore how health information impacts court decisions about removing infants from birth parents.

Methods: Using Arksey and O’Malley’s five-stage method for scoping reviews as a guide, eight electronic databases were searched to identify relevant …

An Examination Of Post-Traumatic Stress Symptoms And Aggression Among Children With A History Of Adverse Childhood Experiences, Elizabeth M. Mcrae, Laura Stoppelbein, Sarah E. O'Kelley, Paula Fite, Shana B. Smith

Research, Publications & Creative Work

Childhood aggression is associated with many deleterious outcomes and is a common reason for psychiatric referral (Card and Little 2006; Gurnani, Ivanov, and Newcorn 2016). One factor associated with childhood aggression is Adverse Childhood Experiences (ACEs; Felitti et al. 1998). However, existing research remains equivocal on which characteristics of ACEs (e.g., cumulative impact, typology, etc.) are significantly elated to aggression, especially when considering differential effects of ACEs on proactive aggression (PA) and reactive aggression (RA; Dodge and Coie, 1987). Post-traumatic stress symptoms (PTSS) are a common negative sequalae of ACEs and are characterized by disruptions in several cognitive, emotional, and …

Détermination Du Formaldéhyde Dans L’Air Par Hplc-Uv, Pierre-Luc Cloutier, Marielle Carrier, Catherine Choinière

Environnementales

No abstract provided.

Détermination De L’Isocyanurate De Triglycidyl (Tgic) Dans L’Air Par Lc-Ms, Pierre-Luc Cloutier, Simon Aubin, Marielle Carrier, Sébastien Gagné

Environnementales

No abstract provided.

Health Reform Reconstruction, Lindsay F. Wiley, Elizabeth Y. Mccuskey, Matthew B. Lawrence, Erin C. Fuse Brown

Faculty Articles

This Article connects the failed, inequitable U.S. coronavirus pandemic response to conceptual and structural constraints that have held back U.S health reform for decades and calls for reconstruction. For more than a half-century, a cramped “iron triangle” ethos has constrained health reform conceptually. Reforms aimed to balance individual interests in cost, quality, and access to health care, while marginalizing equity, solidarity, and public health. In the iron triangle era, reforms unquestioningly accommodated four legally and logistically entrenched fixtures — individualism, fiscal fragmentation, privatization, and federalism — that distort and diffuse any reach toward social justice. The profound racial disparities and …

Examining Organizational Factors And Their Impact On Older Adults In Life Plan Communities, Ajla Basic

Master's Theses

Aging in America continues to reveal multi-faceted concerns for both the industry and retirees; insufficient retirement savings, loneliness, and a high influx of older adults entering the retirement scene. It is expected that by 2030, 18% of the nation's population, the baby boomers, will have turned 65 (Cohn & Taylor, 2010). This demographic reality has led to increased research seeking answers to questions which emerge about the retirement age population. The Age Well Study is a longitudinal study looking at the impact of residing in a Life Plan Community. The data is collected through self-report measures by residents in the …

Plasmodium Tlap-2 Is A Microtubule-Associated Protein With Microtubule Stabilization Properties, Grifin Berge

Master's Theses

Microtubules facilitate major cellular and morphological changes in eukaryotic cells, including the protozoan parasite Plasmodium. Microtubule-associated proteins (MAPs), only very few of which have been characterized in the malaria parasite, regulate the highly dynamic microtubules. Thioredoxin-like associated protein 2 (TLAP2) is a MAP unique to the phylum apicomplexa, which in addition to Plasmodium includes the important human pathogen Toxoplasma. Here we report on the cloning and microtubule-binding activity of TLAP2 of the rodent malaria parasite Plasmodium berghei (PbTLAP2). PbTLAP2 is coded by a single exon gene and consists of 598 amino acids. The protein contains a putative C-terminal microtubule-binding domain. …

Why Is Race A Risk Factor For Infants Born With Birth Defects?: Deconstructing The Biological Basis Of Race In Maternal-Fetal Medicine Through The Lens Of Reproductive Justice, Amrita Bhagia

Master's Theses

Several studies have shown that marginalized populations, especially those of non-white race/ethnicity, have an increased risk of having infants born with severe birth defects. Existing hypotheses from the scientific literature on the topic of birth defects have primarily suggested that these trends may be the result of differential genetic susceptibilities within certain racial groups, a theory that reifies the (currently disproven) biological basis of race. Through this thesis, I argue that the myth of the biological basis of race continues to exist within maternal-fetal medicine today, where it is used to further the narrative that the bodies of women of …

Population-Matched Transcriptome Prediction Increases Discovery And Replication Rate In Twas, Elyse Geoffroy

Master's Theses

Most genome-wide and transcriptome-wide association studies (GWAS, TWAS) focus on European populations; however, these results cannot always be accurately applied to non-European populations due to differences in genetic architecture. Using summary statistics from GWAS in the Population Architecture using Genomics and Epidemiology (PAGE) study, which comprises ~50,000 Hispanic/Latinos, African Americans, Asians, Native Hawaiians, and Native Americans, we perform transcriptome-wide association studies to determine gene-trait associations. Initially, we compared results using two transcriptome prediction models derived from the Multi-Ethnic Study of Atherosclerosis (MESA) populations: the African American (AFA) model and the Hispanic/Latino (HIS) model. We identified 141 unique genome-wide significant trait-associated …

Function Of Mllt3 In Liver Metabolism, Grace Ann Hammack

Master's Theses

The chromatin regulator MLLT3 recognizes target genes through the YEATS domain that identifies post-translationally modified histones, with preference for crotonyl and acetyl marks, and recruits different multiprotein effector complexes through its C-terminal domain to target genes. To study the role of MLLT3 in gene regulation, the Zeleznik-Le and Hemenway labs developed Mllt3 whole-body knockout (Mllt3;Rosa26-CreERT2) mice. These mice have a hematopoietic stem cell phenotype and an unexpected obesity and hepatic steatosis phenotype. It was unknown whether these phenotypes were from liver intrinsic effects or influenced by other parts of the body. To study this fatty liver phenotype further, Mllt3;Alb-Cre were …

Assessing The Role Of The Interaction Between Polyamines And Heparan Sulfate In Coxsackievirus B3 Viral Infection, Oreoluwa Omoba

Master's Theses

Non-polioenteroviruses are highly infectious viruses that typically cause mild asymptomatic cases but can cause severe disease such as aseptic meningitis and dilated cardiomyopathy. Coxsackievirus B3 (CVB3) is a member of this group and is prevalent in the United States and Eastern Asia. Viruses like CVB3 rely on the host cell for many molecules in order to replicate. One such set of molecules is the polyamines. Polyamines are small, positively charged molecules that play a role in a multitude of cellular processes including RNA/DNA stabilization, gene expression, translation, and regulating membrane fluidity. Previous studies have shown CVB3 relies on polyamines for …

Elucidating Regulatory Connections Between The Second Messenger Cyclic-Di-Gmp With Biofilm And Motility Phenotypes Of Vibrio Fischeri, Ali Razvi

Master's Theses

The symbiosis between the gram-negative marine bacterium Vibrio fischeri and its host Euprymna Scolopes occurs when the bacteria reaches and colonizes the light organ. This pathway to colonization begins in the outer marine environment and finishes within the deep crypts of the light organ, with states of biofilm formation and dispersal in between. This switch between biofilm formation to dispersal is important as the bacteria transitions from the surface on the light organ into a pore leading to the interior of the light organ. This dispersal is regulated by LAP system which is dependent on the second messenger c-di-GMP. Through …

Characterization Of Alcohol-Mediated Promotion Of Breast Cancer Stem Cells, Mckenna Below

Master's Theses

Breast cancer is the leading cause of cancer-related death in women globally, and one in eight women will be diagnosed with breast cancer at some point in her life. Alcohol consumption has been linked to increase breast cancer risk and increased risk of tumor recurrence. Understanding the molecular mechanisms of modifiable lifestyle factors such as alcohol consumption will help to lower these risks and design more effective therapeutic approaches. Estrogen Receptor positive (ER+) breast cancer comprises approximately 70% of all breast cancers, and these tumors are effectively targeted by endocrine therapy in the form of estrogen deprivation with aromatase inhibitors, …

Advancing Our Understanding Of Mechanosensitive Microtubule Acetylation In Neurons, Margaret Earl Utgaard

Master's Theses

Stiffness is a signaling cue in the brain, and neuronal response to stiffness impacts development, injury and disease. Mechanotransduction is the process of cells interpreting and converting mechanical cues to biochemical signals. Tubulin acetylation increases microtubule stability and could be mechanosensitive. The impact of stiffness on tubulin acetylation and role of septins is the focus of this project.It was hypothesized that stiffer surfaces would increase tubulin acetylation. SH-SY5Y cells were plated on varying stiffness and the ratio of acetylated to alpha tubulin was measured using immunocytochemistry. This study found SH-SY5Y cells had the highest acetylation on hard surfaces. SH-SY5Y cells …

Characterization And Targeting Of Voltage-Gated Ion Channels In Meningioma Cell Lines, Erik White

Master's Theses

Meningiomas (MN) are primary brain tumors originating in the meningeal covering of the central nervous system. These tissues can evolve through familial inheritance (NF2, Cowden Syndrome, or Werner Syndrome) or sporadic mutations. The WHO categorizes MNs into three grades (I-III); Grade I contain benign tumors and Grade III the most aggressive. Increasing grade coincides with an increase in genetic diversity, making universal treatments difficult. MNs are typically treated with hydroxyurea (HU), but this chemotherapy agent has many adverse side effects, leading to research in less toxic options. This study uses ion channel antagonists for T- and L-type calcium channels using …

Pseudomonas Aeruginosa Prophages And Engineered Temperate Phages, Genevieve Johnson

Master's Theses

The rising rate of antibiotic-resistant bacteria is a global health concern, and the Pseudomonas aeruginosa is estimated to be a leader in serious threats. Bacteriophages, or viruses that infect bacteria, have gained renewed interest in Western Medicine as an alternative to antibiotics. Phage therapy of P. aeruginosa infections has primarily focused on obligately lytic phages. However, prophages, or phages in the lysogenic life cycle, are estimated to far outnumber obligately lytic phages. In theory, these prophages can be genetically modified to be obligately lytic and thus ideal candidates for phage therapy. To date there has not been a comprehensive analysis …

Ethnic Racial Socialization, Ethnic Identity, And Internalizing Outcomes In The Context Of Stress Among Mexican Origin Families, Sarah Alicia Jolie

Master's Theses

Research demonstrates that it is important to study the impact of cultural factors on child development and well-being (Garcia Coll et al., 1996). Among Latino youth, ethnic racial socialization and ethnic identity have been associated with positive outcomes, such as academic competence and lower reports of internalizing problems (Liu & Lau, 2013; Berkel et al., 2010; Umaña-Taylor & Guimond, 2010). Additionally, there is evidence of ethnic identity mediating the association between ethnic racial socialization and child internalizing symptoms among Mexican-origin adolescents (Umaña-Taylor et al., 2014). However, more research is needed in examining these associations within stressful contexts relevant to Latino …

Rethinking Intimacy: Liberation Through Decolonial & Queer World-Making, Michelle Mae Mcguire

Master's Theses

Relationships play an important role in both the private and public spheres of our lives. If we understand our bodies to be the vessels through which we interact with all other objects, we come to understand the process of world-making as a summation of our relationships. Intimacy is the prevailing structure that helps assign meaning to these relationships. Intimacy binds together unfixed spatial and social relations that stretch across time and space. This essay examines the three intersecting sets of relations involved in intimacy as a means to deconstruct heteropatriarchal order and highlight the multiplicity of attachments and relationships that …

Lactobacillus Metabolite-Mediated Induction Of Bacteriophage, Taylor Miller-Ensminger

Master's Theses

Once considered sterile in the absence of an infection, the female urinary tract is home to a diverse community (microbiota) of bacterial species and bacteriophage (phage), viruses that infect bacteria A dominant member of the female urinary microbiota is the bacterial genus Lactobacillus. Several Lactobacillus species are even associated with urinary health. Phage infectious of bacteria in the urinary tract tend to replicate through one of two life cycles: the lytic (active) life cycle or the lysogenic (dormant) life cycle. Temperate phage can switch from the lysogenic life cycle to the lytic life cycle in the presence of an environmental …

The Role Of Intersensory Redundancy In Face Recognition In 5- And 12-Month-Old Infants, Aslı Bursalıoğlu

Master's Theses

The goal of this study was to examine the role of audiovisual synchrony in 5- and 12-month-old infants’ attention to and processing of face stimuli. Infants were tested using an online platform called Lookit. In the first phase of the experiment, infants were familiarized with two videos presented simultaneously and side-by-side. Each video displayed a woman speaking in an infant-directed manner. A soundtrack was played that matched one of the videos (experimental condition) or neither of the videos (control condition). It was hypothesized that synchronous audiovisual presentation would attract infants’ attention and promote processing, especially among 12-month-olds. Visual-paired comparison (VPC) …

Menstrual Pain Trajectories And Their Psychological And Behavioral Predictors, Hannah Marie Alves Hagy

Master's Theses

Despite the high prevalence of menstrual pain (i.e., dysmenorrhea) and the negative impact on quality of life, there is a dearth of research on how menstrual pain changes over time. There is also a critical need to understand psychological and behavioral predictors of these menstrual pain trajectories because dysmenorrhea is a known risk factor for the development of chronic pelvic pain (CPP) and chronic non-pelvic pain (CNPP). Given that current treatments for CPP and CNPP have had limited success, developing preventative strategies for dysmenorrhea is of high importance. Relying on longitudinal survey data collected as part of a larger investigation, …

Kinship Involvement And Strength Development In The Child Welfare System, Nicole Amper Hodgkinson

Master's Theses

For youth involved in the Child Welfare System (CWS), maltreatment and ecological losses pose enormous challenges to healthy development. Kin and fictive kin involvement, a current CWS priority, may have the potential to aid in strength development; however, little is known about its role in this process. The current study explored the following aims: (1) identify the role of kin and fictive kin in strength development (2) investigate the impact of maltreatment on initial strength levels and their development over time and (3) examine the extent to which kinship involvement interacts with prior maltreatment to buffer the impact of maltreatment …

Risk Factors And Knowledge Associated With High Unintended Pregnancy Rates And Low Family Planning Use Among Pregnant Women In Papua New Guinea, Elizabeth Peach, Christopher Morgan, Michelle J. L. Scoullar, Freya J. I. Fowkes, Elissa Kennedy, Pele Melepia, Primrose Homiehombo, Lucy Au, Stanley Luchters, Alexandra J. Umbers

Population Health, East Africa

Unintended pregnancy is a major driver of poor maternal and child health in resource-limited settings. Data on pregnancy intention and use of family planning (FP) is scarce in Papua New Guinea (PNG), but are needed to inform public health strategies to improve FP accessibility and uptake. Data from a facility-based cross-sectional sample of 699 pregnant women assessed prevalence and predictors of unintended pregnancy and modern FP use among pregnant women in East New Britain Province, PNG. More than half (55%) the women reported their pregnancy as unintended. Few (18%) reported ever having used a modern FP method, and knowledge of …

Developing A Self-Assessment Instrument To Evaluate Practice-Readiness Among Student Pharmacists, Channing Ford, Kevin N. Astle, Erika L. Kleppinger, Jeanna Sewell, Amber Hutchison, Kimberly B. Garza

Research, Publications & Creative Work

This chapter explores the role of self-assessment in the development of professional identity formation within student pharmacists.

Evaluating The Impact Of A Longitudinal Patient Case On The Development Of Professionalism And Professional Identity, Kimberly B. Garza, Lindsey E. Moseley, Bradley M. Wright, Channing R. Ford

Research, Publications & Creative Work

This article explores the student outcomes of a progressive case on the development of professional identity and professionalism within first-year student pharmacists.

Victim-Blaming In Disguise? Supervisors’ Accounts Of Problems In Healthcare Delivery, Kendra Jason, Brianna Turgeon

Research, Publications & Creative Work

Using data from 77 supervisors in seven hospitals across the U.S. that participated in a national workforce development program for low-wage frontline workers, we explain how supervisors justified and reproduced social inequalities by accepting culture of poverty and neoliberal discourses and how supervisors used these discourses to resolve identity-work dilemmas. We demonstrate how supervisors engaged in identity talk that justified deprivation for workers and shielded management from blame. We discuss how supervisors subtly invoked class, race, and gender stereotypes—and thus reproduced ideologies supportive of structural inequalities—as they crafted accounts that drew attention away from economic and organizational problems and focused …

Effects Of Beetroot Juice Supplementation On Cognitive Function, Aerobic And Anaerobic Performances Of Trained Male Taekwondo Athletes: A Pilot Study, Hossein Miraftabi, Zahra Avazpoor, Erfan Berjisian, Amir Sarshin, Sajjad Rezaei, Raul Dominguez, Reid Reale, Emerson Franchini, Mohammad Hossein Samanipour, Majid S. Koozehchian, Mark E.T. Willems, Ramin Rafiei, Alireza Naderi

Research, Publications & Creative Work

: Studies have shown that nitrate (NO3 −)-rich beetroot juice (BJ) supplementation improves endurance and high-intensity intermittent exercise. The dose–response effects on taekwondo following BJ supplementation are yet to be determined. This study aimed to investigate two acute doses of 400 mg of NO3 − (BJ-400) and 800 mg of NO3 − (BJ-800) on taekwondo-specific performance and cognitive function tests compared with a placebo (PL) and control (CON) conditions. Eight trained male taekwondo athletes (age: 20 ± 4 years, height: 180 ± 2 cm, body mass: 64.8 ± 4.0 kg) completed four experimental trials using a randomized, double-blind placebo-controlled design: …

Exploring Standardized Persons' Expectations For Practice-Readiness Among Student Pharmacists, Channing R. Ford, Kevin N. Astle, Kimberly B. Garza, Erika L. Kleppinger

Research, Publications & Creative Work

Although patient expectations and preferences for healthcare selection have been described in the literature, there are no studies exploring what qualities and behaviors standardized persons (SPs) identify for the practice-ready pharmacist. This manuscript explores those qualities and behaviors within an objective structured clinical examination (OSCE) to determine SP interest in having the student as their pharmacy provider. Methods: Using open-ended questions via a Qualtrics survey, SPs were asked to provide qualities and behaviors they associated with each of three practice-readiness rating levels. Using a constant comparative approach, the researchers coded the collected data over multiple stages to allow for authentic …