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The Influence Of Oxygen Partial Pressure On The Properties Of Evaporated Alumina Thin Film, Tsion Teklemarim

Theses

Alumina (Al2O3) thin films are used in anti-reflection and high reflection mirror coatings from deep UV to near infrared. The optical, mechanical, and structural properties of films are dependent on the deposition technique and the desired film performance can be achieved by manipulating the deposition parameters. Such deposition parameters are substrate temperature, deposition rate, and oxygen partial pressure. For laser mirror performance applications, it is desirable to optimize the films with regards to laser damage threshold and film stress. To these ends, this thesis work studies Al2O3 thin films synthesized with electron beam evaporation technique as a function of oxygen …

[Introduction To] Race, Removal, And The Right To Remain : Migration And The Making Of The United States / Samantha Seeley., Samantha Seeley

Bookshelf

This work explores the conflicts over migration at the center of the social, political, intellectual, and physical landscape of the early United States. Examining the voluntary and forced migrations of Indigenous, African American, and Anglo Americans in the decades immediately following the Revolution, Samantha Seeley argues that the United States took shape as a white republic through contentious negotiations over who could move and where, who could remain and how. Removal was not sweeping, top-down federal legislation. Instead, it was a battle fought on multiple fronts. It encompassed tribal leaders' attempts to expel white settlers from Native lands and African …

Clinical Activity Of Fianlimab (Regn3767), A Human Anti-Lag-3 Monoclonal Antibody, Combined With Cemiplimab (Anti-Pd-1) In Patients (Pts) With Advanced Melanoma, Guilherme Rabinowits

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No abstract provided.

Phase 1 Trial Of Alrn-6924, A Dual Inhibitor Of Mdmx And Mdm2, In Patients With Solid Tumors And Lymphomas Bearing Wild-Type Tp53, Guilherme Rabinowits

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Abstract

Purpose: We describe the first-in-human dose-escalation trial for ALRN-6924, a stabilized, cell-permeating peptide that disrupts p53 inhibition by MDM2 and MDMX to induce cell cycle arrest or apoptosis in TP53 wild-type tumors.

Methods: Two schedules were evaluated for safety, pharmacokinetics, pharmacodynamics, and anti-tumor effects in patients with solid tumors or lymphomas: In arm A, patients received ALRN-6924 by intravenous infusion once-weekly for 3 weeks every 28 days; arm B, was twice-weekly for 2 weeks every 21 days.

Results: Seventy-one patients were enrolled: 41 in arm A (0.16-4.4 mg/kg), 30 in arm B (0.32-2.7 mg/kg). ALRN-6924 showed dose-dependent pharmacokinetics and …

Occupational Exposure To Antineoplastic Drugs: What About Hospital Sanitation Personnel?, France Labrèche, Capucine Ouellet, Brigitte Roberge, Nicolas J Caron, Ahmed Yennek, Jean-François Bussières

Études primaires

Objective

Occupational exposure to antineoplastic drugs (ANPs) occurs mainly through dermal contact. Our study was set up to assess the potential exposure of hospital sanitation (HS) personnel, for whom almost no data are available, through contamination of surfaces they regularly touch.

Methods

In the oncology departments of two hospitals around Montreal, surface wipe samples of 120–2000 cm² were taken at 10 sites cleaned by the HS personnel and five other sites frequently touched by nursing and pharmacy personnel. A few hand wipe samples were collected to explore skin contamination. Wipes were analyzed by ultra-performance liquid chromatography tandem–mass spectrometry for …

Leakage Versus Material Filtration In Barrier Facemask Efficiency, Ali Bahloul, Clothilde Brochot, Barbara Layne

Études primaires

The World Health Association and many governmental agencies recommend the wearing of facemasks by the general public to prevent the spread of COVID-19. It is believed that masks can significantly protect others and may offer some protection to the wearer. Although there are standards for FFRs, surgical masks, and recently for barrier face coverings, they all indicate the level of protection for the wearer. However, testing facial masks not at the point of inhalation, but at the source, the exhale, offers a new perspective on how to impede particle emissions. In this paper, the experimental results show that, although the …

On The Removal Of The Open Earcanal High-Pass Filter Effect Due To Its Occlusion: A Bone-Conduction Occlusion Effect Theory, Kevin Carillo, Olivier Doutres, Franck Sgard

Études primaires

The occlusion effect is commonly experienced by in-ear device wearers as an increased loudness sensation of bone-conducted low frequency sounds. A widespread theory proposed by Tonndorf and based on a simplified electro-acoustic model describes the phenomenon as the removal of the open earcanal high-pass filter effect due to a perfect or partial occlusion. However, this filter has not been clearly defined and several ambiguities remain. Revisiting the model, a second order high-pass filter effect for the volume velocity transferred between the earcanal wall and the eardrum is highlighted. This filter remains for partial occlusion but vanishes for perfect occlusion. In …

Role And Responsibilities Of Supervisors In The Sustainable Return To Work Of Workers Following A Work-Related Musculoskeletal Disorder, Iuliana Nastasia, Marie-France Coutu, Romain Rives, Jessica Dubé, Sarah Gaspard, Audrey Quilicot

Études primaires

Purpose Supervisors play an important role during the return to work (RTW) of injured workers. Yet little research has been done on the actions associated with this role or the contexts in which they are taken. The purpose of this study was to develop courses of action to promote supervisors’ involvement in the process aimed at achieving sustainable RTW for workers following a work-related musculoskeletal disorder (MSD), and to verify their pertinence, feasibility, and applicability in practice. Methods A two-phase qualitative method was used. (1) Secondary content analysis of 46 interviews of 14 workers post-MSD and 32 other actors in …

Principle Of An Acoustical Method For Estimating The Centroid Position Of The Earcanal Wall Normal Velocity Induced By Bone-Conducted Stimulation: Numerical Evaluation, Kevin Carillo, Olivier Doutres, Franck Sgard

Études primaires

The occlusion effect is commonly experienced as the altered perception of one’s own physiological noise when the earcanal entrance is blocked. Objectively, this phenomenon corresponds to an acoustic pressure increase in the occluded earcanal. The occlusion effect originates from the earcanal wall normal vibration and depends on the spatial distribution of the latter. At low frequencies, this spatial distribution can be characterized by the position of its centroid along the earcanal middle axis. This paper describes the principle of an acoustical method for estimating this centroid position at low frequencies. The proposed method consists in measuring the eardrum acoustic pressure …

The Effect Of Extensible And Non-Extensible Lumbosacral Orthoses On Anticipatory Postural Adjustments In Participants With Low Back Pain And Healthy Controls, Christian Larivière, Richard Preuss

Études primaires

Background

Wearing a lumbosacral orthosis (LSO) is known to influence spine mechanics, but less is known about how LSOs affect motor control. Whether the use of a LSO can negatively affect motor control of the lumbar spine is still under debate.

Objective

The current study examined the immediate effects of two flexible LSOs (extensible and non-extensible) on the anticipatory postural adjustments that prepare the spine for a predictable perturbation.

Design

A comparative study using a repeated measures design in a laboratory setting.

Methods

Healthy controls (n = 20) and participants with low back pain (n = 40) performed a rapid …

Structural Remodeling Of The Lumbar Multifidus, Thoracolumbar Fascia And Lateral Abdominal Wall Perimuscular Connective Tissues: A Search For Its Potential Determinants, Christian Larivière, Sharon M. Henry, Richard Preuss

Études primaires

Recently remodeling of lumbar soft tissues has received increased research attention. However, the major determinants that influence remodeling need to be elucidated in order to understand the impact of different rehabilitation modalities on tissue remodeling. The main aim of this study was to explore the between-subject variance of different measures of lumbar soft tissues quantified with rehabilitative ultrasound imaging (RUSI). RUSI measures (n = 8) were collected from 30 subjects without and 34 patients with LBP: (1) lumbar multifidus (LM) echogenicity (fatty infiltration/fibrosis) at three vertebral levels (L3/L4, L4/L5 and L5/S1) (n = 3); (2) posterior layer thickness …

Structural Remodeling Of The Lumbar Multifidus, Thoracolumbar Fascia And Lateral Abdominal Wall Perimuscular Connective Tissues: Medium-Term Test-Retest Reliability Of Ultrasound Measures, Christian Larivière, Dany H. Gagnon, Richard Preuss

Études primaires

Abstract

Introduction

Growing interest is being paid to the lumbar multifidus (LM) intramuscular fatty infiltrations and fibrosis that are secondary to low back pain as well to the remodeling of perimuscular connective tissues (fasciae) such as the thoracolumbar fascia and fascia sheets separating the abdominalwall muscles. Magnetic resonanceimaging and computed tomography have traditionally been used but rehabilitative ultrasound imaging (RUSI) is much more affordable and practical, which can accelerate research and clinical applications on this topic. The aim of this study was to test the medium-term (8 weeks) test-retest reliability of the corresponding RUSI measures.

Methods

Thirty-four participants …

Novel Adaptive Sampling Algorithm For Pod-Based Non-Intrusive Reduced Order Model, Jiachen Wang, Xiaosong Du, Joaquim R.R.A. Martins

Mechanical and Aerospace Engineering Faculty Research & Creative Works

The proper orthogonal decomposition (POD) based reduced-order model (ROM) has been an effective tool for flow field prediction in the engineering industry. The sample selection in the design space for POD basis construction affects the ROM performance sensitively. Adaptive sampling can significantly reduce the number of samples to achieve the required model accuracy. In this work, we propose a novel adaptive sampling algorithm, called conjunction sampling strategy, which is based on proven strategies. The conjunction sampling strategy is demonstrated on airfoil flow field prediction within the transonic regime. We demonstrate the performance of the proposed strategy by running 10 trials …

New Hampshire Baseline Needs Assessment: Covid-19 Impact On Substance Use And Treatment, Center On Rural Addiction, University Of Vermont, Nh Citizens Health Initiative

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No abstract provided.

Cost And Utilization Of Treatment For Diabetes In New Hampshire: Analysis Of Medical And Pharmacy All-Payer Claims Data, Erica-Lyn Plante, Amy Costello, Josephine B. Porter, H. Chris White

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No abstract provided.

Combined Influence Of Transfer Distance, Pace, Handled Mass And Box Height On Spine Loading And Posture, Xavier Robert-Lachaine, Philippe Corbeil, Antoine Muller, Jasmin Vallée-Marcotte, Hakim Mecheri, Denys Denis, André Plamondon

Études primaires

Work-related low back disorders are commonly associated with handling tasks. The objective of this study was to determine the combined influence of distance, pace, handled mass and height, on back loading and posture during free box transfer. Kinematics and kinetics of 17 handlers were recorded during a box transfer task between two pallets. Four-way repeated measures ANOVA were conducted on four lift-deposit height conditions (from lift and deposit of 0.16 or 1.16 m), three distances between pallets (1.5, 1.0 and 0.5 m), two handled masses (10 and 20 kg) and two paces (free and faster). The interaction between distance and …

New Hampshire Baseline Needs Assessment: Practitioner Comfort Treating Substance Use Disorder, Center On Rural Addiction, University Of Vermont, Nh Citizens Health Initiative

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This data brief focuses on practitioners’ responses regarding their comfort treating patients with opioid use disorder (OUD) and other SUDs

Set It In Stone: Investing In 21st Century Broadband In New Hampshire To Secure Telehealth For All Residents, Institute For Health Policy And Practice (Ihpp), New Hampshire Telehealth Alliance, Deborah H. Fournier

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No abstract provided.