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2021

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Lost In Time And Lost In Space: Chronotopes In Thomas Pynchon’S Against The Day, Stephen Margavio Sep 2021

Lost In Time And Lost In Space: Chronotopes In Thomas Pynchon’S Against The Day, Stephen Margavio

Honors Theses

In his 1937 essay “Forms of Time and of the Chronotope in the Novel,” Russian literary theorist Mikhail Bakhtin coins the term “chronotope” to discuss the inherently interconnected nature of time and space in narrative constructions. According to Bakhtin, there are a number of specific chronotopes (or space/time configurations) that help to define literary genres. Applying Bakhtin’s concepts to Thomas Pynchon’s novel Against the Day (2006), this thesis examines how the idea of narrative space/time can clarify Pynchon’s use of genre to make socio-political commentary. The first chapter of this thesis focuses on Bakhtin’s “road chronotope,” which is characterized by …

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Nature’S Rights, Christiana Ochoa Sep 2021

Nature’S Rights, Christiana Ochoa

Michigan Journal of Environmental & Administrative Law

Do forests and rivers possess standing to sue? Do mountain ranges have substantive rights? A recent issue of The Judges’ Journal, a preeminent publication for American judges, alerts the bench, bar, and policymakers to the rapidly emerging “rights of nature,” predicting that state and federal courts will increasingly see claims asserting such rights. Within the United States, Tribal law has begun to legally recognize the rights of rivers, mountains, and other natural features. Several municipalities across the United States have also acted to recognize the rights of nature. United States courts have not yet addressed the issue, though in 2017, …

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Blazing A Path To Wilderness: A Case Study Of Impact Litigation Through The Lens Of Legislative History, Neil Kagan Sep 2021

Blazing A Path To Wilderness: A Case Study Of Impact Litigation Through The Lens Of Legislative History, Neil Kagan

Michigan Journal of Environmental & Administrative Law

Litigation can be a catalyst for legislation. Legislative history can reveal just how influential litigation is. The legislative history of the laws to designate wilderness in the 1980s provides an object lesson. It demonstrates that litigation both pushed Congress to act and shaped the legislation Congress enacted. This is especially true of the watershed year of 1984. That year, Congress enacted more wilderness laws and added more wilderness areas to the National Wilderness Preservation System in more states than in any other year. The legislative history of the 1984 wilderness laws embedded in bills, hearings, committee meetings, committee reports, and …

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Composition Over Division: The Statutes Of The National Forest System, Jamison E. Colburn Sep 2021

Composition Over Division: The Statutes Of The National Forest System, Jamison E. Colburn

Michigan Journal of Environmental & Administrative Law

In September 2020, the U.S. Forest Service took the extraordinary step of closing all 18 national forests in California. The risk of catastrophic fire had become so acute that tolerating any human visitors—who could ignite more—was no longer tenable. Damages from the fires of 2020 are still being tallied, but the catastrophe is hard to deny. Five of the state’s six largest fires on record occurred in 2020. Migrating birds dropped from the sky by the thousands from some combination of asphyxiation, exhaustion, and starvation. An estimated 80% of California’s watersheds had recently burned by 2019, leaving them immediately vulnerable …

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Multifunctional Corrosion Control System As A Sustainable Approach For Reinforced Concrete Elements, Homero Castaneda, Miladin Radovic, Brendy Rincon, Oladis Troconis, Arturo Montoya, Changkyu Kim, Loreto Dacio Sep 2021

Multifunctional Corrosion Control System As A Sustainable Approach For Reinforced Concrete Elements, Homero Castaneda, Miladin Radovic, Brendy Rincon, Oladis Troconis, Arturo Montoya, Changkyu Kim, Loreto Dacio

Publications

Corrosion inhibitors can be utilized to decrease the corrosion kinetics and therefore increase the durability of reinforced concrete structures. Recently, a green synthesized organic compound, 1-benzyl-4-phenyl-1H-1,2,3-triazole (BPT), was shown to be a successful green organic corrosion inhibitor for mild steel. Studies suggested that the BPT adsorbs chemically onto the steel and acts as a mixed inhibitor, suppressing both the anodic and cathodic corrosion kinetics of steel. In addition, microcapsules have shown to be an efficient way for a controlled inhibitor release in reinforced concrete structures. On the other hand, geopolymers (GPs) comprised of a long range of covalently bonded alumino-silicates, …

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Multiple Species And Deep Genomic Divergences Despite Little Phenotypic Differentiation In An Ancient Neotropical Songbird, Tunchiornis Ochraceiceps (Sclater, 1860) (Aves: Vireonidae), N Buainain, M F. Maximiano, M Ferreira, A Aleixo, N Buainain, R T. Brumfield, J Cracraft, C C. Ribas Sep 2021

Multiple Species And Deep Genomic Divergences Despite Little Phenotypic Differentiation In An Ancient Neotropical Songbird, Tunchiornis Ochraceiceps (Sclater, 1860) (Aves: Vireonidae), N Buainain, M F. Maximiano, M Ferreira, A Aleixo, N Buainain, R T. Brumfield, J Cracraft, C C. Ribas

Faculty Publications

Several bird taxa have been recently described or elevated to full species and almost twice as many bird species than are currently recognized may exist. Defining species is one of the most basic and important issues in biological science because unknown or poorly defined species hamper subsequent studies. Here, we evaluate the species limits and evolutionary history of Tunchiornis ochraceiceps-a widespread forest songbird that occurs in the lowlands of Central America, Choco and Amazonia-using an integrative approach that includes plumage coloration, morphometrics, vocalization and genomic data. The species has a relatively old crown age (similar to 9 Ma) and comprises …

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Genome-Wide Association And Selective Sweep Studies Reveal The Complex Genetic Architecture Of Dmi Fungicide Resistance In Cercospora Beticola, Rebecca Spanner, Demetris Taliadoros, Jonathan Richards, Viviana Rivera-Varas, Jonathan Neubauer, Mari Natwick, Olivia Hamilton, Niloofar Vaghefi, Sarah Pethybridge, Gary A. Secor, Timothy L. Friesen, Eva H. Stukenbrock, Melvin D. Bolton Sep 2021

Genome-Wide Association And Selective Sweep Studies Reveal The Complex Genetic Architecture Of Dmi Fungicide Resistance In Cercospora Beticola, Rebecca Spanner, Demetris Taliadoros, Jonathan Richards, Viviana Rivera-Varas, Jonathan Neubauer, Mari Natwick, Olivia Hamilton, Niloofar Vaghefi, Sarah Pethybridge, Gary A. Secor, Timothy L. Friesen, Eva H. Stukenbrock, Melvin D. Bolton

Faculty Publications

The rapid and widespread evolution of fungicide resistance remains a challenge for crop disease management. The demethylation inhibitor (DMI) class of fungicides is a widely used chemistry for managing disease, but there has been a gradual decline in efficacy in many crop pathosystems. Reliance on DMI fungicides has increased resistance in populations of the plant pathogenic fungus Cercospora beticola worldwide. To better understand the genetic and evolutionary basis for DMI resistance in C. beticola, a genome-wide association study (GWAS) and selective sweep analysis were conducted for the first time in this species. We performed whole-genome resequencing of 190 C. beticola …

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Trapping Soybean Looper (Lepidoptera: Noctuidae) In The Southeastern Usa And Implications For Pheromone-Based Research And Management, Daniel E. Fleming, Jeffrey A. Davis, Fred R. Musser, Silvana V. Paula-Moraes, Ronald C. Stephenson, Christopher A. Wheeler, Earl Eugene Ringpis, Tyler S. Crum, J. Khai Tran Sep 2021

Trapping Soybean Looper (Lepidoptera: Noctuidae) In The Southeastern Usa And Implications For Pheromone-Based Research And Management, Daniel E. Fleming, Jeffrey A. Davis, Fred R. Musser, Silvana V. Paula-Moraes, Ronald C. Stephenson, Christopher A. Wheeler, Earl Eugene Ringpis, Tyler S. Crum, J. Khai Tran

Faculty Publications

Novel strategies for the management of soybean looper, Chrysodeixis includens (Walker) (Lepidoptera: Noctuidae), are needed due to its increasing importance, costs, and challenges of management in soybeans (Glycine max [L.] Merr.; Fabaceae) in the Americas. Pheromone-mediated mating disruption may be 1 such novel strategy, but an effective tool for estimating mating disruption success must be found. The technique of trapping male moths using pheromone baited traps is a common method for assessing mating disruption technology. This paper reports on the testing of 2 trap types and 3 commercially available lures containing (Z)-7-dodecenyl acetate as the major active component. Trapping was …

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Managing Corpses From Different Castes In The Eastern Subterranean Termite, Jizhe Shi, Chi Zhang, Sirui Huang, Austin Merchant, Qian Sun, Chuan Zhou, Kenneth F. Haynes, Xuguo Zhou Sep 2021

Managing Corpses From Different Castes In The Eastern Subterranean Termite, Jizhe Shi, Chi Zhang, Sirui Huang, Austin Merchant, Qian Sun, Chuan Zhou, Kenneth F. Haynes, Xuguo Zhou

Faculty Publications

Corpse management is essential for social animals to maintain colony health. In the eastern subterranean termite, Reticulitermes flavipes, workers carry out undertaking behaviors to mitigate the risks associated with the dead. In this study, we hypothesized that termites would respond differently to the corpses from different castes based on their postmortem chemical signatures. To test this hypothesis, we 1) documented the behavioral responses of the workers toward corpses from different castes, and 2) profile the chemical signatures of these corpses. Corpses from all castes were retrieved inside the nests and cannibalized when they were decomposed <64 >h, regardless of the presence …

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Biology, Ecology, And Pest Management Of The Tarnished Plant Bug, Lygus Lineolaris (Palisot De Beauvois) In Southern Row Crops, Justin George, James P. Glover, Jeffrey Gore, Whitney D. Crow, Gadi V.P. Reddy Sep 2021

Biology, Ecology, And Pest Management Of The Tarnished Plant Bug, Lygus Lineolaris (Palisot De Beauvois) In Southern Row Crops, Justin George, James P. Glover, Jeffrey Gore, Whitney D. Crow, Gadi V.P. Reddy

Faculty Publications

The tarnished plant bug, Lygus lineolaris (Palisot de Beauvois), (Hemiptera: Miridae) is considered the most damaging pest of cotton (Gossypium hirsutum L.) in the mid-southern United States, although it is established throughout the United States, southern Canada, and northern Mexico. The introduction of transgenic crops for the control of moths in the Heliothine complex and eradication of the boll weevil, Anthonomus grandis, from much of the United States led to greatly reduced pesticide use in cotton fields, which allowed L. lineolaris to emerge as a new primary pest of cotton in the mid-southern United States. Since the publication of a …

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Development Of A Method For Rearing Nezara Viridula (Heteroptera: Pentatomidae) On A Semi-Solid Artificial Diet, Maribel Portilla, Gadi V.P. Reddy Sep 2021

Development Of A Method For Rearing Nezara Viridula (Heteroptera: Pentatomidae) On A Semi-Solid Artificial Diet, Maribel Portilla, Gadi V.P. Reddy

Faculty Publications

A method for rearing the southern green stinkbug, (Nezara viridula L.) (Heteroptera: Pentatomidae), using a modified lygus semi-solid artificial diet was developed. First to second-instar nymph were reared in a density of 631.5 ± 125.05 eggs per Petri-dish (4 cm deep × 15 cm diam). Second instar to adult were reared in a density of 535.0 ± 112.46 s instar nymphs per rearing cage (43 × 28 × 9 cm). Mating and oviposition occurred in popup rearing cages (30 × 30 cm), each holding 60-90 mixed sex adults of similar age. Adults emerged 35.88 ± 2.13 d after oviposition and …

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A Tale Of Two Representations: Energy And Time In Photoabsorption, A. R.P. Rau Sep 2021

A Tale Of Two Representations: Energy And Time In Photoabsorption, A. R.P. Rau

Faculty Publications

This essay is based on a talk at Advances in Atomic, Molecular, and Optical Sciences 2020 (AAMOS20) in a symposium honoring Prof. S. T. Manson's decades-long contribution to photoabsorption studies. Quantum physics introduced into physics pairs of conjugate quantities bearing a specific complementary relationship, energy and time being one such pair. This gives rise to two alternative representations, a time-dependent and a time-independent one, seemingly very different but both capable of embracing the same physics. They give complementary descriptions and insight, with technical questions, theoretical and experimental, determining which may be the more convenient and practicable at any juncture. Two …

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A 3d Printed Vitrification Device For Storage In Cryopreservation Vials, Yue Liu, Andy Lin, Terrence R. Tiersch, William Todd Monroe Sep 2021

A 3d Printed Vitrification Device For Storage In Cryopreservation Vials, Yue Liu, Andy Lin, Terrence R. Tiersch, William Todd Monroe

Faculty Publications

Sperm cryopreservation by vitrification is a promising approach for small-bodied animals such as zebrafish (Danio rerio). However, most vitrification tools adopted in aquatic research were initially designed for applications other than sperm (such as human embryo freezing) and, thus, pose challenges for adoption to sperm vitrification. Three-dimensional (3D) printing combined with open hardware sharing is an emerging strategy to address challenges in the development of cryo-preservation tools. The goal of this study was to develop a 3D printed Vitrification Device for Cryo-Vials (VDCV) that can be integrated with the existing vial storage systems. The VDCV combined the vitrification and handling …

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Pioglitazone Reverses Markers Of Islet Beta-Cell De-Differentiation In Db/Db Mice While Modulating Expression Of Genes Controlling Inflammation And Browning In White Adipose Tissue From Insulin-Resistant Mice And Humans, J. Jason Collier, Heidi M. Batdorf, Kaelan L. Merrifield, Thomas M. Martin, Ursula White, Eric Ravussin, David H. Burk, Chris R. Cooley, Michael D. Karlstad, Susan J. Burke Sep 2021

Pioglitazone Reverses Markers Of Islet Beta-Cell De-Differentiation In Db/Db Mice While Modulating Expression Of Genes Controlling Inflammation And Browning In White Adipose Tissue From Insulin-Resistant Mice And Humans, J. Jason Collier, Heidi M. Batdorf, Kaelan L. Merrifield, Thomas M. Martin, Ursula White, Eric Ravussin, David H. Burk, Chris R. Cooley, Michael D. Karlstad, Susan J. Burke

Division of Basic Science Faculty Publications

Obesity, insulin resistance, and type 2 diabetes contribute to increased morbidity and mortality in humans. The db/db mouse is an important mouse model that displays many key features of the human disease. Herein, we used the drug pioglitazone, a thiazolidinedione with insulin-sensitizing properties, to investigate blood glucose levels, indicators of islet β-cell health and maturity, and gene expression in adipose tissue. Oral administration of pioglitazone lowered blood glucose levels in db/db mice with a corresponding increase in respiratory quotient, which indicates improved whole-body carbohydrate utilization. In addition, white adipose tissue from db/db mice and from humans treated with pioglitazone showed …

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Fgf21 Prevents Low-Protein Diet-Induced Renal Inflammation In Aged Mice, Han Fang, Sujoy Ghosh, Landon C. Sims, Kirsten P. Stone, Cristal M. Hill, Denisha Spires, Daria V. Ilatovskaya, Christopher D. Morrison, Thomas W. Gettys, Krisztian Stadler Sep 2021

Fgf21 Prevents Low-Protein Diet-Induced Renal Inflammation In Aged Mice, Han Fang, Sujoy Ghosh, Landon C. Sims, Kirsten P. Stone, Cristal M. Hill, Denisha Spires, Daria V. Ilatovskaya, Christopher D. Morrison, Thomas W. Gettys, Krisztian Stadler

Division of Basic Science Faculty Publications

Low-protein (LP) diets extend lifespan through a comprehensive improvement in metabolic health across multiple tissues and organs. Many of these metabolic responses to protein restriction are secondary to transcriptional activation and release of FGF21 from the liver. However, the effects of an LP diet on the kidney in the context of aging has not been examined. Therefore, the goal of the current study was to investigate the impact of chronic consumption of an LP diet on the kidney in aging mice lacking FGF21. Wild-Type (WT; C57BL/6J) and FGF21 knockout (KO) mice were fed a normal protein diet (20% casein) or …

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Population Structure, Gene Flow, And Sex-Biased Dispersal In The Reticulated Flatwoods Salamander (Ambystoma Bishopi): Implications For Translocations, Steven T. Williams, Jean P. Elbers, Sabrina S. Taylor Sep 2021

Population Structure, Gene Flow, And Sex-Biased Dispersal In The Reticulated Flatwoods Salamander (Ambystoma Bishopi): Implications For Translocations, Steven T. Williams, Jean P. Elbers, Sabrina S. Taylor

Faculty Publications

Understanding patterns of gene flow and population structure is vital for managing threatened and endangered species. The reticulated flatwoods salamander (Ambystoma bishopi) is an endangered species with a fragmented range; therefore, assessing connectivity and genetic population structure can inform future conservation. Samples collected from breeding sites (n = 5) were used to calculate structure and gene flow using three marker types: single nucleotide polymorphisms isolated from potential immune genes (SNPs), nuclear data from the major histocompatibility complex (MHC), and the mitochondrial control region. At a broad geographical scale, nuclear data (SNP and MHC) supported gene flow and little structure (FST …

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Hydraulically-Vulnerable Trees Survive On Deep-Water Access During Droughts In A Tropical Forest, Rutuja Chitra-Tarak, Chonggang Xu, Salomón Aguilar, Kristina J. Anderson-Teixeira, Jeff Chambers, Matteo Detto, Boris Faybishenko, Rosie A. Fisher, Ryan G. Knox, Charles D. Koven, Lara M. Kueppers, Nobert Kunert, Stefan J. Kupers, Nate G. Mcdowell, Brent D. Newman, Steven R. Paton, Rolando Pérez, Laurent Ruiz, Lawren Sack, Jeffrey M. Warren, Brett T. Wolfe, Cynthia Wright, S. Joseph Wright, Joseph Zailaa, Sean M. Mcmahon Sep 2021

Hydraulically-Vulnerable Trees Survive On Deep-Water Access During Droughts In A Tropical Forest, Rutuja Chitra-Tarak, Chonggang Xu, Salomón Aguilar, Kristina J. Anderson-Teixeira, Jeff Chambers, Matteo Detto, Boris Faybishenko, Rosie A. Fisher, Ryan G. Knox, Charles D. Koven, Lara M. Kueppers, Nobert Kunert, Stefan J. Kupers, Nate G. Mcdowell, Brent D. Newman, Steven R. Paton, Rolando Pérez, Laurent Ruiz, Lawren Sack, Jeffrey M. Warren, Brett T. Wolfe, Cynthia Wright, S. Joseph Wright, Joseph Zailaa, Sean M. Mcmahon

Faculty Publications

Deep-water access is arguably the most effective, but under-studied, mechanism that plants employ to survive during drought. Vulnerability to embolism and hydraulic safety margins can predict mortality risk at given levels of dehydration, but deep-water access may delay plant dehydration. Here, we tested the role of deep-water access in enabling survival within a diverse tropical forest community in Panama using a novel data-model approach. We inversely estimated the effective rooting depth (ERD, as the average depth of water extraction), for 29 canopy species by linking diameter growth dynamics (1990–2015) to vapor pressure deficit, water potentials in the whole-soil column, and …

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Reliability Of Measurements Of Energy Expenditure And Substrate Oxidation Using Whole-Room Indirect Calorimetry, Timothy D. Allerton, Elvis A. Carnero, Christopher Bock, Karen D. Corbin, Pierre Philippe Luyet, Steven R. Smith, Eric Ravussin Sep 2021

Reliability Of Measurements Of Energy Expenditure And Substrate Oxidation Using Whole-Room Indirect Calorimetry, Timothy D. Allerton, Elvis A. Carnero, Christopher Bock, Karen D. Corbin, Pierre Philippe Luyet, Steven R. Smith, Eric Ravussin

Clinical Research Faculty Publications

Objective: This analysis aimed to measure the intraparticipant reliability—the intraclass correlation coefficient—of all the components of daily energy expenditure (EE) (24-hour EE, sleep EE, resting EE, basal EE, and thermic effect of food) over a period of 3 consecutive days in 35 study participants. Methods: The components of daily EE and substrate use (respiratory exchange ratio) were measured over 3 consecutive days before and after a 3-week 1,000-kcal/d caloric restriction/weight-loss intervention. Results: There was a high degree of reliability for sleep EE (96.8%), 24-hour EE (97.8%), basal EE (90.6%), and resting EE (93.2%) during the run-in period. The intraclass correlation …

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Effects Of Testosterone Undecanoate On Performance During Multi-Stressor Military Operations: A Trial Protocol For The Optimizing Performance For Soldiers Ii Study, Alyssa N. Varanoske, Melissa N. Harris, Callie Hebert, Emily E. Howard, Neil M. Johannsen, Steven B. Heymsfield, Frank L. Greenway, Lee M. Margolis, Harris R. Lieberman, David D. Church, Arny A. Ferrando, Jennifer C. Rood, Stefan M. Pasiakos Sep 2021

Effects Of Testosterone Undecanoate On Performance During Multi-Stressor Military Operations: A Trial Protocol For The Optimizing Performance For Soldiers Ii Study, Alyssa N. Varanoske, Melissa N. Harris, Callie Hebert, Emily E. Howard, Neil M. Johannsen, Steven B. Heymsfield, Frank L. Greenway, Lee M. Margolis, Harris R. Lieberman, David D. Church, Arny A. Ferrando, Jennifer C. Rood, Stefan M. Pasiakos

Clinical Research Faculty Publications

Background: Previously, young males administered 200 mg/week of testosterone enanthate during 28 days of energy deficit (EDef) gained lean mass and lost less total mass than controls (Optimizing Performance for Soldiers I study, OPS I). Despite that benefit, physical performance deteriorated similarly in both groups. However, some experimental limitations may have precluded detection of performance benefits, as performance measures employed lacked military relevance, and the EDef employed did not elicit the magnitude of stress typically experienced by Soldiers conducting operations. Additionally, the testosterone administered required weekly injections, elicited supra-physiological concentrations, and marked suppression of endogenous testosterone upon cessation. Therefore, this …

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Assessing Biodegradable Mulch Duration And Nutsedge Suppression During Late Summer Cucumber Production In Mississippi And Louisiana, Kathryn Fontenot, Heather Kirk-Ballard, Christine Elizabeth Harris Coker, Ronald Strahan, Isabel Bacas, Robert Michael Ely Sep 2021

Assessing Biodegradable Mulch Duration And Nutsedge Suppression During Late Summer Cucumber Production In Mississippi And Louisiana, Kathryn Fontenot, Heather Kirk-Ballard, Christine Elizabeth Harris Coker, Ronald Strahan, Isabel Bacas, Robert Michael Ely

Faculty Publications

Environmental concerns as well as labor costs associated with the use of polyethylene plastic mulch have turned producers’ focus to alternative mulch treatments. A preliminary study was conducted to evaluate nutsedge control, mulch degradation, and cucumber yields on biodegradable mulches at two locations (Louisiana and Mississippi). Mulch treatments included two paper-based mulch products, two biodegradable plastic mulches, the industry standard non-biodegradable black plastic mulch, and an unmulched control. The heavy weight paper-based mulch and light weight paper mulches in the Louisiana location were reduced to 50% or less coverage at the end of the study. Similarly, the paper-based mulches both …

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Global Flash Drought Monitoring Using Surface Soil Moisture, Vinit Sehgal, Nandita Gaur, Binayak P. Mohanty Sep 2021

Global Flash Drought Monitoring Using Surface Soil Moisture, Vinit Sehgal, Nandita Gaur, Binayak P. Mohanty

Faculty Publications

Abrupt onset and swift intensification characterize flash droughts. Global surface soil moisture (θRS) from NASA's Soil Moisture Active Passive (SMAP) satellite can facilitate a near-real-time assessment of emerging flash droughts at a 36-km footprint. However, a robust flash drought monitoring using θRS must account for the (a) short observation record of SMAP, (b) nonlinear geophysical controls over θRS dynamics, and (c) emergent meteorological drivers of flash droughts. We propose a new method for near-real-time characterization of droughts using Soil Moisture Stress (SMS, drought stress) and Relative Rate of Drydown (RRD, drought stress intensification rate)—developed using SMAP θRS (March 2015–May 2021), …

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Moringa Oleifera Seed Extract Concomitantly Supplemented With Chemotherapy Worsens Tumor Progression In Mice With Triple Negative Breast Cancer And Obesity, Elizabeth R.M. Zunica, Shengping Yang, Ann Coulter, Christy White, John P. Kirwan, Linda A. Gilmore Sep 2021

Moringa Oleifera Seed Extract Concomitantly Supplemented With Chemotherapy Worsens Tumor Progression In Mice With Triple Negative Breast Cancer And Obesity, Elizabeth R.M. Zunica, Shengping Yang, Ann Coulter, Christy White, John P. Kirwan, Linda A. Gilmore

Division of Basic Science Faculty Publications

Triple negative breast cancer (TNBC) is an aggressive and highly metastatic breast cancer subtype with limited treatment options. Obesity and insulin resistance are associated with a worse prognosis in those with TNBC. Moringa oleifera (moringa) is a tropical edible plant used for both food and medicinal purposes and found to have anti-obesity and anti-cancer effects in vitro and in preclinical models. The anti-cancer effects of moringa seed extract alone and in combination with chemotherapy were evaluated in immunocompromised female mice with diet-induced obesity bearing MDA-MB-231-derived xenograft tumors. Moringa supplementation protected against high-fat diet-and chemotherapy-induced increases in fasting glucose and improved …

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Effects Of Experimental Sleep Restriction On Ambulatory And Sleep Blood Pressure In Healthy Young Adults: A Randomized Crossover Study, Naima Covassin, Jan Bukartyk, Prachi Singh, Andrew D. Calvin, Erik K. St Louis, Virend K. Somers Sep 2021

Effects Of Experimental Sleep Restriction On Ambulatory And Sleep Blood Pressure In Healthy Young Adults: A Randomized Crossover Study, Naima Covassin, Jan Bukartyk, Prachi Singh, Andrew D. Calvin, Erik K. St Louis, Virend K. Somers

Clinical Research Faculty Publications

Although insufficient sleep is associated with increased cardiovascular risk, evidence of a causal relationship is lacking. We investigated the effects of prolonged sleep restriction on 24-hour ambulatory blood pressure (BP) and other cardiovascular measures in 20 healthy young participants (aged 23.4±4.8 years, 9 females), who underwent a randomized, controlled, crossover, 16-day inpatient study consisting of 4 days of acclimation, 9 days of sleep restriction (4 hours of sleep/night) or control sleep (9 hours), and 3 days of recovery. Subjects consumed a weight maintenance diet with controlled nutrient composition throughout. A 24-hour BP (primary outcome) and cardiovascular biomarkers were measured repeatedly. …

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Particulate Matter Exposure Predicts Residence In High-Risk Areas For Community Acquired Pneumonia Among Hospitalized Children, Tonny J. Oyana, Jagila Minso, Tamekia L. Jones, Jonathan A. Mccullers, Sandra R. Arnold, Stephania A. Cormier Sep 2021

Particulate Matter Exposure Predicts Residence In High-Risk Areas For Community Acquired Pneumonia Among Hospitalized Children, Tonny J. Oyana, Jagila Minso, Tamekia L. Jones, Jonathan A. Mccullers, Sandra R. Arnold, Stephania A. Cormier

Division of Basic Science Faculty Publications

Particulate matter exposure is a risk factor for lower respiratory tract infection in children. Here, we investigated the geospatial patterns of community-acquired pneumonia and the impact of PM2.5 (particulate matter with an aerodynamic diameter ≤2.5 µm) on geospatial variability of pneumonia in children. We performed a retrospective analysis of prospectively collected population-based surveillance study data of community-acquired pneumonia hospitalizations among children < 18 years residing in the Memphis metropolitan area, who were enrolled in the Centers for Disease Control and Prevention sponsored Etiology of Pneumonia in the Community (EPIC) study from January 2010 to June 2012. The outcome measure, residence in high- and low-risk areas for community-acquired pneumonia, was determined by calculating pneumonia incidence rates and performing cluster analysis to identify areas with higher/lower than expected rates of community-acquired pneumonia for the population at risk. High PM2.5 was defined as exposure to PM2.5 concentrations greater than the mean value (>10.75 μg/m3), and low PM2.5 is defined as exposure to PM2.5 concentrations less than or equal to the mean value (≤10.75 μg/m3). We also assessed the effects of age, sex, race/ethnicity, history of wheezing, insurance type, tobacco smoke exposure, …

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Choices Sep 2021

Choices

In Case You Missed It

SEPTEMBER 2021

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The Necessity And Possibility Of Decolonizing The Understanding Of Chinese-Ness, Tao Zhang Sep 2021

The Necessity And Possibility Of Decolonizing The Understanding Of Chinese-Ness, Tao Zhang

Dissertations

In this dissertation, I explore how crossing national borders has made me aware of the many identity borders that I have crossed as a transnational Chinese, and how I am caught up in identity politics between the “Chinese,” who do not necessarily always identify as “Chinese” in the transnational context. However, as a racialized group in the U.S., transnational Chinese are perceived as a homogeneous population, usually through racially (“Yellow Peril” or “Chinese Virus”) and politically (“Red Scare”) charged lenses measured by Western/U.S. binaristic and hierarchical standards. Therefore, in this research project, I problematize dominant U.S. race logic, i.e., the …

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Risk Factor For 31-Day Unplanned Readmission To Hospital In Patients With Pulmonary Tuberculosis In China, Jing Cao, Shengpeng Liu, Juhua Huang Sep 2021

Risk Factor For 31-Day Unplanned Readmission To Hospital In Patients With Pulmonary Tuberculosis In China, Jing Cao, Shengpeng Liu, Juhua Huang

Saudi Medical Journal

Objectives: To evaluate risk factors associated with 31-day unplanned readmission(s) for pulmonary tuberculosis (TB) in China. Methods: This retrospective study enrolled patients (age, >14 years) with pulmonary TB who experienced 31-day unplanned readmissions to a specialized hospital for TB between January 2018 and December 2019. For each confirmed readmission, 2 control subjects were randomly selected from among patients with pulmonary TB but did not experience an unplanned readmission within 31 days. Results: A total of 402 pulmonary TB patients (5.9%) experienced unplanned readmission within 31 days after discharge. In univariate analysis, readmission was associated with gender, age, insurance coverage, residing …

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Phagocytes Produce Prostaglandin E2 In Response To Cytosolic Listeria Monocytogenes, Courtney E. Mcdougal, Zachary T. Morrow, Tighe Christopher, Seonyoung Kim, Drake Carter, David M. Stevenson, Daniel Amador-Noguez, Mark J. Miller, John-Demian Sauer Sep 2021

Phagocytes Produce Prostaglandin E2 In Response To Cytosolic Listeria Monocytogenes, Courtney E. Mcdougal, Zachary T. Morrow, Tighe Christopher, Seonyoung Kim, Drake Carter, David M. Stevenson, Daniel Amador-Noguez, Mark J. Miller, John-Demian Sauer

Open Access Publications

Listeria monocytogenes is an intracellular bacterium that elicits robust CD8+ T-cell responses. Despite the ongoing development of L. monocytogenes-based platforms as cancer vaccines, our understanding of how L. monocytogenes drives robust CD8+ T-cell responses remains incomplete. One overarching hypothesis is that activation of cytosolic innate pathways is critical for immunity, as strains of L. monocytogenes that are unable to access the cytosol fail to elicit robust CD8+ T-cell responses and in fact inhibit optimal T-cell priming. Counterintuitively, however, activation of known cytosolic pathways, such as the inflammasome and type I IFN, lead to impaired immunity. Conversely, production of prostaglandin E2 …

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Endothelial Fgf Signaling Is Protective In Hypoxia-Induced Pulmonary Hypertension, Kel Vin Woo, Isabel Y Shen, Carla J Weinheimer, Attila Kovacs, Jessica Nigro, Chieh-Yu Lin, Murali Chakinala, Derek E Byers, David M Ornitz Sep 2021

Endothelial Fgf Signaling Is Protective In Hypoxia-Induced Pulmonary Hypertension, Kel Vin Woo, Isabel Y Shen, Carla J Weinheimer, Attila Kovacs, Jessica Nigro, Chieh-Yu Lin, Murali Chakinala, Derek E Byers, David M Ornitz

Open Access Publications

Hypoxia-induced pulmonary hypertension (PH) is one of the most common and deadliest forms of PH. Fibroblast growth factor receptors 1 and 2 (FGFR1/2) are elevated in patients with PH and in mice exposed to chronic hypoxia. Endothelial FGFR1/2 signaling is important for the adaptive response to several injury types and we hypothesized that endothelial FGFR1/2 signaling would protect against hypoxia-induced PH. Mice lacking endothelial FGFR1/2, mice with activated endothelial FGFR signaling, and human pulmonary artery endothelial cells (HPAECs) were challenged with hypoxia. We assessed the effect of FGFR activation and inhibition on right ventricular pressure, vascular remodeling, and endothelial-mesenchymal transition …

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By Grace And Faith, Isabella Koh Sep 2021

By Grace And Faith, Isabella Koh

Lake Union Herald

No abstract provided.

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