Digital Commons Network^™

The Hox Protein Conundrum: The “Specifics” Of Dna Binding For Hox Proteins And Their Partners, Bony De Kumar, Diane C. Darland

Biology Faculty Publications

Homeotic genes (Hox genes) are homeodomain-transcription factors involved in conferring segmental identity along the anterior-posterior body axis. Molecular characterization of HOX protein function raises some interesting questions regarding the source of the binding specificity of the HOX proteins. How do HOX proteins regulate common and unique target specificity across space and time? This review attempts to summarize and interpret findings in this area, largely focused on results from in vitro and in vivo studies in Drosophila and mouse systems. Recent studies related to HOX protein binding specificity compel us to reconsider some of our current models for transcription factor-DNA …

Law Helps Ensure Safety Of The Supply Chain, Kenneth Maxik, Craig Kimble, Alberto Coustasse

Management Faculty Research

The Drug Quality and Security Act was signed into law on November 27, 2013, and included the Title 2 Drug Supply Chain and Security Act (DSCSA). This legislation was introduced to enact a federal prescription drug safety standard to decrease contamination, counterfeiting, diversion, and otherwise harmful illicit activities. It also improves the detection and elimination of potentially unsafe drugs from the drug supply chain to protect US consumers.

Otoliths Of South-Western Australian Fish: A Photographic Catalogue, Chris Dowling, Kim Smith, Elaine Lek, Joshua Brown

Fisheries Research Reports

Due to the species-specific nature of otoliths and given they are often the only part of the fish preserved when fish die, otolith catalogues can be used in numerous applications, such as diet studies in fish eating animals, including pinnipeds, fish and sea birds; archaeological purposes such as reconstructing indigenous people’s diets from otoliths found in middens or evolutionary history of fish species by comparing fossilized otoliths. Given the unique mixture of subtropical and temperate fish, including many endemic species that occur off the southwest corner of WA having a catalogue for this area is extremely important for people working …

Une Ufa Aac Library Subcommittee Resource Highlight: Research And Teaching Librarians, Une Library Services

UFA AAC Library Sub-Committee Library Resource Highlights

September 2021 library resources highlight compiled for the University Faculty Assembly Academic Affairs Committee's Library Sub-committee at the University of New England. Focus on: Research and Teaching Librarians' offerings for faculty.

Development And Validation Of A Model To Predict Posttraumatic Stress Disorder And Major Depression After A Motor Vehicle Collision, Steven Bruce, Hannah Ziobrowski, Chris Kennedy, Berk Ustun, Stacey House, Francesca Beaudoin, Xinming An, Donglin Zeng, Kenneth Bollen, Maria Petukhova, Nancy Sampson, Victor Puac-Polanco, Sue Lee, Karestan Koenen, Kerry Ressler, Samuel Mclean, Ronald Kessler, Aurora Consortium

Psychology Faculty Works

Importance A substantial proportion of the 40 million people in the US who present to emergency departments (EDs) each year after traumatic events develop posttraumatic stress disorder (PTSD) or major depressive episode (MDE). Accurately identifying patients at high risk in the ED would facilitate the targeting of preventive interventions.Objectives To develop and validate a prediction tool based on ED reports after a motor vehicle collision to predict PTSD or MDE 3 months later.Design, Setting, and Participants The Advancing Understanding of Recovery After Trauma (AURORA) study is a longitudinal study that examined adverse posttraumatic neuropsychiatric sequalae among patients who presented to …

Meditation-Induced After Death Communication: A Contemporary Modality For Grief Therapy, Neda Wassie

International Journal of Transpersonal Studies

Meditation-induced after death communication (MI-ADC) was introduced as a potential modality for grief therapy. Traditional and contemporary approaches were compared in order to evaluate effective paradigms and theories of bereavement. The Continuing Bonds theory of attachment emerged as an adaptive framework for grief therapy, especially with attention to meaning-making and the strength of continued bonds. Considerations were implemented from research in psychomanteum, mediumship, and induced after death communication. Specifically, visual stimuli and timing of after death communications were emphasized. The discussion was encouraging for the conceptualization of MI-ADC as an effective construct and as an inquiry for empirical research.

Locating The Embodied Sense Of Self And Examining Its Relationship With Psychological Well-Being, Adam Wesley Hanley, Natalie Lecy, Robert Hanley

International Journal of Transpersonal Studies

Westerners tend to localize their sense of self in the head, and, to a lesser degree, in the chest. However, single-point, localization studies of the self omit direct exploration of the size and shape of the embodied self. This study explored a) beliefs about the location and spatial distribution of the embodied sense of self, and b) whether individual differences in how the embodied self was represented were associated with psychological and subjective well-being. Results from a sample of 206 American adults confirm extant reports, indicating that the embodied sense of self is most often located in the head and …

Exercise-Induced Oxidative Stress And Melatonin Supplementation: Current Evidence, Joanna Kruk, Basil Hassan Aboul-Enein, Ewa Duchnik

Health & Wellness Department Faculty Publications and Research

Melatonin possesses the indoleamine structure and exerts antioxidant and anti-inflammatory actions and other physiological properties. Physical exercise can influence secretion of melatonin. Melatonin is used as a natural supplement among athletes to regulate sleep cycles and protect muscles against oxidative damage. Despite decades of research, there is still a lack of a comprehensive and critical review on melatonin supplementation and physical activity relationship. The aim of this literature review is to examine the antioxidant, anti-inflammatory and other biological functions played by melatonin with reference to the effect of physical exercise on melatonin secretion and the effect of this compound supplementation …

Harris Friedman: Pioneer Of Transpersonal Psychology As A Science, Harris L. Friedman, Glenn Hartelius

International Journal of Transpersonal Studies

N/A

Brain Activity During Paired And Individual Mindfulness Meditation: A Controlled Eeg Study, Hessel Engelbregt, Hugo F. Alderse Bass, Sietske De Grauw, Jan Berend Deijen

International Journal of Transpersonal Studies

Objective: In this study, we evaluated brain electroencephalographic (EEG) activity in healthy participants during the performance of paired and individual mindfulness meditation (MM). We hypothesized that EEG activity is differentially affected by meditation in pairs compared to individual meditation. Methods: A total of 20 healthy female university students (mean age 19.54 years, SD =1.53) with no prior experience in MM participated in this study. All participants had to perform a 5-minute MM task together and individually while the other participant was in rest or performing a concentration task (control condition). To exclude social interaction as main factor, participants were separated …

Wofford College Catalogue 2021-2022, Wofford College. Office Of The Registrar

College Catalogues

No abstract provided.

A Newly Identified Impairment In Both Vision And Hearing Increases The Risk Of Deterioration In Both Communication And Cognitive Performance, Dawn M. Guthrie, Nicole Williams, Jennifer Campos, Paul Mick, Joseph B. Orange, M. Kathleen Pichora-Fuller, Marie Y. Savundranayagam, Walter Wittich, Natalie A. Phillips

Health Sciences Faculty Publications

Vision and hearing impairments are highly prevalent in adults 65 years of age and older. There is a need to understand their association with multiple health-related outcomes. We analyzed data from the Resident Assessment Instrument for Home Care (RAI-HC). Home care clients were followed for up to 5 years and categorized into seven unique cohorts based on whether or not they developed new vision and/or hearing impairments. An absolute standardized difference (stdiff) of at least 0.2 was considered statistically meaningful. Most clients (at least 60%) were female and 34.9 per cent developed a new sensory impairment. Those with a new …

2021-2022 Catalog, College Of The Holy Cross

Course Catalogs

This catalog lists available courses for the 2021-2022 academic year. The College Catalog is a document of record issued in September 2021. The Catalog contains current information regarding the College calendar, admissions, degree requirements, fees, regulations and course offerings. It is not intended to be, and should not be relied upon, as a statement of the College’s contractual undertakings.

Neur 280.01: Fundamentals Of Neuroscience, Katie M. Holick, Michael P. Kavanaugh

University of Montana Course Syllabi

No abstract provided.

Rsif Pan-Africa Progress Report 2021 - English, Regional Scholarship And Innovation Fund (Rsif)

Rsif Reports and Institutional Documents

Rsif is the first Pan-African Science fund of its kind connecting innovative minds to resources for revolutionary solutions. It is the flagship product of PASET, an initiative led by African governments aimed at building skills of citizens of sub-Saharan Africa countries in the field of applied sciences, engineering, and technology for national economic growth on the continent. Rsif builds sustainable doctoral training, highly advanced research and innovation ecosystems to develop transformative technologies in Africa for economic growth and development. Contributing countries: Benin, Burkina Faso, Côte d’Ivoire, Ghana, Kenya, Mozambique, Nigeria, Rwanda and Senegal have made or are at the final …

Anty 595.02: Special Topics - Issues In Arctic Cultural Heritage, Anna M. Prentiss

University of Montana Course Syllabi

No abstract provided.

Biob 486.01: Genomics, Jeffrey M. Good

University of Montana Course Syllabi

No abstract provided.

Corticosterone's Roles In Avian Migration: Assessment Of Three Hypotheses, Carolyn M. Bauer, H. E. Watts

Biology Faculty Works

While corticosterone (CORT) is often suggested to be an important hormone regulating processes necessary for avian migration, there has been no systematic assessment of CORT's role in migration. Prior to migration, birds increase fat stores and flight muscle size to prepare for the high energetic costs associated with long-distance flight. After attaining sufficient energetic stores, birds then make the actual decision to depart from their origin site. Once en route birds alternate between periods of flight and stopovers, during which they rest and refuel for their next bouts of endurance flight. Here, we evaluate three non-mutually exclusive hypotheses that have …

Addressing Distress Management Challenges: Recommendations From The Consensus Panel Of The American Psychosocial Oncology Society And The Association Of Oncology Social Work, Teresa L. Deshields, Sharla Wells-Di Gregorio, Stacy R. Flowers, Kelly E. Irwin, Ryan Nipp, Lynne Padgett, Brad Zebrack

Family Medicine Faculty Publications

Distress management (DM) (screening and response) is an essential component of cancer care across the treatment trajectory. Effective DM has many benefits, including improving patients’ quality of life; reducing distress, anxiety, and depression; contributing to medical cost offsets; and reducing emergency department visits and hospitalizations. Unfortunately, many distressed patients do not receive needed services. There are several multilevel barriers that represent key challenges to DM and affect its implementation. The Consolidated Framework for Implementation Research was used as an organizational structure to outline the barriers and facilitators to implementation of DM, including: 1) individual characteristics (individual patient characteristics with a …

961mo Safety, Efficacy, Immunogenicity Of Arenavirus-Based Vectors Hb-201 And Hb-202 In Patients With Hpv16+ Cancers, M. R. Posner, A. L. Ho, J. Niu, L. Nabell, R. S. Leidner, J. Nieva, D. L. Richardson, A. T. Pearson, Ding Wang, K. Chung, D. R. Adkins, A. Pimentel, S. Wong, C. Lacobucci, X. Qing, K. Katchar, K. Schlienger, I. Matushansky, S. Fu, D. G. Pfister

Hematology/Oncology Meeting Abstracts

Background: Human papillomavirus 16 positive (HPV16+) cancers are caused by stable expression of HPV16-specific E7 and E6 oncoproteins, also a source of immunogenic neoantigens. Replicating arenavirus vectors HB-201 (LCMV) and HB-202 (Pichinde virus), expressing the same non-oncogenic HPV16 E7E6 fusion protein, induce tumour-specific T-cell responses.

Methods: A phase I first-in-human study assessed HB-201 monotherapy and HB-201 & HB-202 alternating 2-vector therapy (HB-201/HB-202) intravenously (IV) with or without 1 intratumoral dose (IT/IV) in HPV16+ cancers. Safety, tolerability, and preliminary anti-tumour activity by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 or immune RECIST were evaluated, as well as immunogenicity and pharmacodynamic …

1281o Atezolizumab (Atezo) Vs Platinum-Based Chemo In Blood-Based Tumour Mutational Burden-Positive (Btmb+) Patients (Pts) With First-Line (1l) Advanced/Metastatic (M)Nsclc: Results Of The Blood First Assay Screening Trial (Bfast) Phase Iii Cohort C, R. Dziadziuszko, S. Peters, Shirish M. Gadgeel, S. M. Shagan, E. Felip, A. Morabito, P. Cheema, M. C. Dols, Z. Andric, C. H. Barrios, M. Yamaguchi, E. Dansin, P. Danchaivijitr, M. Johnson, S. Novello, D. R. Gandara, E. Schleifman, J. Wang, T. S.K. Mok

Hematology/Oncology Meeting Abstracts

Background: TMB is a promising biomarker for immunotherapy in NSCLC, but current data are mostly retrospective. As not all pts may have sufficient tissue for comprehensive biomarker testing, bTMB was prospectively tested as a novel biomarker using targeted next-generation sequencing. BFAST (NCT03178552), a global, open-label, multi-cohort trial, evaluated safety and efficacy of targeted therapies or immunotherapy in biomarker-selected pts with unresectable mNSCLC. Here we present results from Cohort C of 1L atezo vs platinum-based chemo in pts with bTMB+ mNSCLC.

Methods: We planned to randomise ≈440 pts with 1L mNSCLC with measurable disease per RECIST 1.1 and bTMB ≥10 (9.1 …

2021 September - East Tennessee State University Retirees Association Newsletter, Retirees Association, East Tennessee State University

ETSU Retirees Association Newsletters

No abstract provided.

Amulet: A Novel Read Count-Based Method For Effective Multiplet Detection From Single Nucleus Atac-Seq Data., Asa Thibodeau, Alper Eroglu, Christopher S Mcginnis, Nathan Lawlor, Djamel Nehar-Belaid, Romy Kursawe, Radu Marches, Daniel N Conrad, George A Kuchel, Zev J Gartner, Jacques Banchereau, Michael L. Stitzel, A Ercument Cicek, Duygu Ucar

Faculty Research 2021

Detecting multiplets in single nucleus (sn)ATAC-seq data is challenging due to data sparsity and limited dynamic range. AMULET (ATAC-seq MULtiplet Estimation Tool) enumerates regions with greater than two uniquely aligned reads across the genome to effectively detect multiplets. We evaluate the method by generating snATAC-seq data in the human blood and pancreatic islet samples. AMULET has high precision, estimated via donor-based multiplexing, and high recall, estimated via simulated multiplets, compared to alternatives and identifies multiplets most effectively when a certain read depth of 25K median valid reads per nucleus is achieved.

Biol 432-101: Introduction To Computational Neuroscience, Horacio Rotstein

Biology Syllabi

No abstract provided.

Biol 201-001: Foundations Of Biology: Cellular & Molecular Biology, Mary Konsolaki

Biology Syllabi

No abstract provided.

Biol 200-003: Concepts In Biology, Maria Stanko

Biology Syllabi

No abstract provided.

Biol 202-101: Foundation Of Biology: Cellular & Mollecular Lab, John Yarotsky

Biology Syllabi

No abstract provided.

Biol 605-101: Principles Of Bioscience Processing, John Yarotsky

Biology Syllabi

No abstract provided.

Anty 210n.01: Introduction To Physical Anthropology, Randall Royce Skelton

University of Montana Course Syllabi

No abstract provided.

Bioo 475.02: Mammalogy Lab, Jedediah Farrell Brodie, Angela Hornsby

University of Montana Course Syllabi

No abstract provided.