Digital Commons Network^™

Assessment Of Non-Saccharomyces Yeast Species As Secondary Fermenters In Beer, Paul J. Clark

Master of Science in Integrative Biology Theses

Secondary fermentation of beer is traditionally used to condition and refine the sensory profile of a beer. During methods such as barrel aging or lagering, the yeast continues to produce flavor-active compounds. Some methods include the intentional inoculation of microorganisms or the utilization of natural consortia associated with a barrel, fruit, or additive for the generation of desired sensory profiles. As unique products increase in popularity, brewers have begun to experiment with secondary fermentation using alternative yeast species as bioflavorants. To assess the viability of an organism’s application to brewing, the physiochemical properties of beer and their impact on the …

Super-Enhancer-Based Identification Of A Batf3/Il-2r-Module Reveals Vulnerabilities In Anaplastic Large Cell Lymphoma, Huan-Chang Liang, Mariantonia Costanza, Nicole Prutsch, Mark W. Zimmerman, Elisabeth Gurnhofer, Ivonne A. Montes-Mojarro, Brian J. Abraham, Nina Prokoph, Stefan Stoiber, Shahid Pervez

Department of Pathology and Laboratory Medicine

Anaplastic large cell lymphoma (ALCL), an aggressive CD30-positive T-cell lymphoma, comprises systemic anaplastic lymphoma kinase (ALK)-positive, and ALK-negative, primary cutaneous and breast implant-associated ALCL. Prognosis of some ALCL subgroups is still unsatisfactory, and already in second line effective treatment options are lacking. To identify genes defining ALCL cell state and dependencies, we here characterize super-enhancer regions by genome-wide H3K27ac ChIP-seq. In addition to known ALCL key regulators, the AP-1-member BATF3 and IL-2 receptor (IL2R)-components are among the top hits. Specific and high-level IL2R expression in ALCL correlates with BATF3 expression. Confirming a regulatory link, IL-2R-expression decreases following BATF3 knockout, and …

Simulation For A Mems-Based Ctrnn Ultra-Low Power Implementation Of Human Activity Recognition, Muhammad Emad-Ud-Din, Mohammad H. Hasan, Roozbeh Jafari, Siavash Pourkamali, Fadi M. Alsaleem

Durham School of Architectural Engineering and Construction: Faculty Publications

This paper presents an energy-efficient classification framework that performs human activity recognition (HAR). Typically, HAR classification tasks require a computational platform that includes a processor and memory along with sensors and their interfaces, all of which consume significant power. The presented framework employs microelectromechanical systems (MEMS) based Continuous Time Recurrent Neural Network (CTRNN) to performHAR tasks very efficiently. In a real physical implementation, we show that the MEMS-CTRNN nodes can perform computing while consuming power on a nano-watts scale compared to the micro-watts state-of-the-art hardware. We also confirm that this huge power reduction doesn’t come at the expense of reduced …

Connecting The Dots: Research Discovery Using Network Analysis Algorithms, Soma Prasad, Rupak Chakravarty

Library Philosophy and Practice (e-journal)

The purpose of the study is to examine the process of research discovery using network analysis algorithm. To assess the paper discovery module and other associated features, the paper titled “Lifetime Prevalence and Age-of-Onset Distributions of DSM-IV Disorders in the National Comorbidity Survey Replication” as selected as “seed paper” authored by American sociologist “Ronald C Kessler”, Professor of Health Care Policy at Harvard Medical School. The findings of the experimental study revealed that unlike traditional citation databases which would yield results by keyword or topic search, Inciteful creates a graph of academic papers based on selected “seed papers” which …

The Dynamic Proteome Of Lyme Disease Borrelia, Anahita Fouladzadeh, Mohsen Dorraki, Kay Khine Myo Min, Michaelia P Cockshell, Emma J Thompson, Johan W Verjans, Andrew Allison, Claudine S Bonder, Derek Abbott

Faculty, Staff and Student Publications

The growth of solid tumours relies on an ever-increasing supply of oxygen and nutrients that are delivered via vascular networks. Tumour vasculature includes endothelial cell lined angiogenesis and the less common cancer cell lined vasculogenic mimicry (VM). To study and compare the development of vascular networks formed during angiogenesis and VM (represented here by breast cancer and pancreatic cancer cell lines) a number of in vitro assays were utilised. From live cell imaging, we performed a large-scale automated extraction of network parameters and identified properties not previously reported. We show that for both angiogenesis and VM, the characteristic network path …

A Molecular Survey Of Bacterial Species In The Guts Of Black Soldier Fly Larvae (Hermetia Illucens) Reared On Two Urban Organic Waste Streams In Kenya, Marwa Shumo, Fathiya M. Khamis, Fidelis Levi Ombura, Chrysantus M. Tanga, Komi K.M. Fiaboe, Sevgan Subramanian, Sunday Ekesi, Oliver K. Schlüter, Arnold Van Huis, Christian Borgemeister

All Peer-Reviewed Publications

Globally, the expansion of livestock and fisheries production is severely constrained due to the increasing costs and ecological footprint of feed constituents. The utilization of black soldier fly (BSF) as an alternative protein ingredient to fishmeal and soybean in animal feed has been widely documented. The black soldier fly larvae (BSFL) used are known to voraciously feed and grow in contaminated organic wastes. Thus, several concerns about their safety for inclusion into animal feed remain largely unaddressed. This study evaluated both culture-dependent sequence-based and 16S rDNA amplification analysis to isolate and identify bacterial species associated with BSFL fed on chicken …

Complex Photobiont Diversity In The Marine Lichen Lichina Pygmaea, Nathan A.M. Chrismas, Ro Allen, Anita L. Hollingsworth, Joe D. Taylor, Michael Cunliffe

School of Biological and Marine Sciences

AbstractLichens are a well-known symbiosis between a host mycobiont and eukaryote algal or cyanobacterial photobiont partner(s). Recent studies have indicated that terrestrial lichens can also contain other cryptic photobionts that increase the lichens’ ecological fitness in response to varying environmental conditions. Marine lichens live in distinct ecosystems compared with their terrestrial counterparts because of regular submersion in seawater and are much less studied. We performed bacteria 16S and eukaryote 18S rRNA gene metabarcoding surveys to assess total photobiont diversity within the marine lichen Lichina pygmaea (Lightf.) C. Agardh, which is widespread throughout the intertidal zone of Atlantic coastlines. We found …

Scaling Limits Of Some Random Interface Models., Biltu Dan Dr.

Doctoral Theses

In this thesis, we study some probabilistic models of random interfaces. Interfaces between different phases have been topic of considerable interest in statistical physics. These interfaces are described by a family of random variables, indexed by the ddimensional integer lattice, which are considered as a height configuration, namely they indicate the height of the interface above a reference hyperplane. The models are defined in terms of an energy function (Hamiltonian), which defines a Gibbs measure on the set of height configurations. More formally, letÏ• = {Ï•x}x∈Z dbe a collection of real numbers indexed by the d-dimensional integer lattice Z d. …

Spectrum, Volume 47, Issue 2, Sacred Heart University

Newspapers (Obelisk & Spectrum)

Highlights include: Covid-19 Spikes Again -- Solar Powered by 2035 -- U.S. Banned From Europe -- Biden’s Student Loan Forgiveness -- Favorite Spots to Dine on Campus -- Sacred Heart Names First Female Athletic Director, Judy Ann Riccio -- Adjunct Professor Erik Hanson in the Department of Languages and Literature published his debut horror collection titled All Things Deadly (Salem Stories) -- New York Fashion Week -- SHU will be featured in the newest episode of Amazon Prime’s TV series The College Tour -- Men’s and Women’s Cross Country Off to the Races -- Women’s Soccer Team Kicks Off Season, …

Faculty Senate Agenda

Faculty Senate Agendas

No abstract provided.

Using Praise To Increase Visual Attending In An Asynchronous Online Learning Environment: An Eye Tracking Study, Andrew J. Rozsa Iii

Master's Theses

With the emergence of online courses in the mid-1990s, the number of students enrolled in online courses has been growing at an exponential rate (Schwirzke, Vashaw, & Watson, 2018). This trend brings with it new problems, such as familiarity with evidence-supported behavioral techniques that will maintain student engagement and improve likelihood of academic success in online learning environments. The purpose of the present study was to examine how the use of praise may affect visual engagement with video lectures with the assistance of commercially available eye tracking technology. A secondary objective of the study was to identify how praise affects …

Discovery Of Potent Bet Bromodomain 1 Stereoselective Inhibitors Using Dna-Encoded Chemical Library Selections, Rajesh Sharma, Kyoung-Jae Choi, My Diem Quan, Sonum Sharma, Banumathi Sankaran, Hyekyung Park, Anel Lagrone, Jean J Kim, Kevin R Mackenzie, Allan Chris M Ferreon, Choel Kim, Josephine C Ferreon

Faculty, Staff and Students Publications

Expression of a few master transcription factors can reprogram the epigenetic landscape and three-dimensional chromatin topology of differentiated cells and achieve pluripotency. During reprogramming, thousands of long-range chromatin contacts are altered, and changes in promoter association with enhancers dramatically influence transcription. Molecular participants at these sites have been identified, but how this re-organization might be orchestrated is not known. Biomolecular condensation is implicated in subcellular organization, including the recruitment of RNA polymerase in transcriptional activation. Here, we show that reprogramming factor KLF4 undergoes biomolecular condensation even in the absence of its intrinsically disordered region. Liquid-liquid condensation of the isolated KLF4 …

Government Response To Covid-19 And Gender Discrepancy: Tour Operator Perspective From New Zealand, Marie Haley, Asif Hussain

Journal of Sustainability and Resilience

The New Zealand government closed the international borders for the first time in history to pursuit an elimination strategy to COVID-19. This has had a severe impact upon tour operators who have been excluded from a free and fair market, to protect the broader economic and public health systems. This paper argues that the government response needs a focus at the whanau and community level, with a targeted focus on women empowerment in the communities that are dependent upon international tourism. The government should pursue an approach of engagement with systems to facilitate community lead COVID-19 recovery. Thus, allowing the …

Futurizing Gastronomic Experiences In Natural Environments, Francesc Fusté-Forné

Journal of Sustainability and Resilience

The current pandemic accentuated the need for a more responsible tourism system, where local food production and consumption become a cornerstone of sustainable tourism futures. Experiences embedded in natural environments are neither new nor recent, but the pandemic urged tourism stakeholders to look at nature again as a source of inspiration for tourism regeneration. The research analyses the configuration of gastronomic experiences in protected areas through the philosophy of a gourmet restaurant located in a volcanic setting in Catalonia, north-eastern Spain.

Flexible Mold For Microstructures Replication, Zefu Ren, Dae Won Kim

Student Works

Space debris has been a growing concern in space exploration sector. To combat this issue, biomimicry is utilized to create a gecko’s feet microstructure that will be attached to a gripper or robotic arm. This will enable capture of debris through the use of dry adhesive microstructure. However, the production of such microstructures is expensive which hinders their implementation. The objective of this research is to develop an advanced fabrication process to mass produce gecko’s feet microstructure with soft polymer mold. The possibility of using different coating methods with coating materials will be justified. The process of fabricating mold and …

Telesecundaria Of Mexico, Jose Calderoni

Online Journal of Space Communication

A perspective by one who has spent many years working in a distance education program that is successful…

Mexico's Educational Satellite Program

Vermiculations In Painted Caves: New Inputs From Laboratory Experiments And Field Observations, Perrine Freydier, Eric Weber, Jérôme Martin, Pierre-Yves Jeannin, Béatrice Guerrier, Frédéric Doumenc

International Journal of Speleology

Vermiculations are aggregates of small particles commonly found on cave walls. They are a major concern for the conservation of painted caves, as they can potentially alter valuable prehistoric cave paintings. A previous rheological study of fine sediment deposits on cave walls revealed that this material can undergo a solid-to-liquid transition triggered by variations in the chemical composition of the water film on the wall. Such a transition could occur at the origin of vermiculations by allowing the sediment to flow under low mechanical stress. In this work, we provide quantitative information on the conditions leading to this transition and …

Nutritive Value Of Double Cropped Corn For Ruminant Production, D. Vaz Martins, A. Fassio

IGC Proceedings (1977-2023)

The viability of double cropping corn (Zea mays L.) in Uruguay, germplasm combination, dry matter yield and nutritive value were evaluated. An early (E) maturing hybrid, an early to medium (E-M) one and an E-M variety were planted as spring crops. One E-M hybrid, one medium to late (M-L) hybrid and a late (L) variety were planted as a second crop. PVC laboratory scale silo of the spring crop and the whole plant of the summer crop were chemically analyzed. The nutritive value of the silages were related to plant maturity stage. No differences were detected in nutritive value among …

Two-Dimensional Monitoring Of Spatial Distribution Of Herbage Mass Under Grazing, S. Ogura, Masahiko Hirata

IGC Proceedings (1977-2023)

Spatial distribution of herbage mass (HM) was monitored two-dimensionally during the grazing season (from May to November) in a bahiagrass pasture rotationally grazed by cattle. An electronic capacitance probe was used to estimate HM in 1464 permanent positions (50 × 50 cm) whose centres formed 1.5 × 1.5 m grids in the central 90 × 34.5 m area of the pasture. The highest mean HM was in September and October, while coefficient of variation in November. The two-dimensional charting of HM showed almost stable spatial patterns throughout the grazing season, with some patches of high HM appearing and disappearing. The …

The Effect Of Herbage Mass Of A Pasture On The Spatially Heterogeneous Grazing By Cattle, S. Ogura, Masahiko Hirata

IGC Proceedings (1977-2023)

To obtain information on spatially heterogeneous grazing by large herbivores at different time scales, spatial distribution of herbage mass and rate of defoliation was investigated on a bahiagrass (Paspalum notatum Flügge) pasture grazed by cattle during 4 to 5-day grazing periods in May, August and October. Pre-grazing herbage mass (M_pre) showed decreasing mean values and increasing spatial heterogeneity with the progress of grazing in all grazing periods, while the rate of defoliation showed inconsistent changes with season. Spatial distribution of the rate of defoliation was always more heterogeneous than that of M_pre. The correlation coefficient …

Relationships Between Spatial Distributions Of Herbage Mass And Utilization In A Pasture Progressively Grazed By Cattle, Masahiko Hirata, S. Ogura

IGC Proceedings (1977-2023)

To obtain some information about the mechanisms behind the spatially heterogeneous grazing of a pasture by large herbivores, the relationships between the spatial distributions of herbage mass, herbage consumption and ingestive behavior were investigated on a bahiagrass (Paspalum notatum Flügge) pasture during a 6-day grazing period with cattle. The animals almost always consumed more herbage from locations with higher pre-grazing herbage masses, which was attributed to greater bite weights. It was suggested that the high spatial heterogeneity in the rate of defoliation was caused mainly by the spatial heterogeneity in both the bite weight and the number of visits …

Based On Atmospheric Physics And Ecological Principle To Assess The Accuracies Of Field Co2 /H2o Measurements From Infrared Gas Analyzers In Closed-Path Eddy-Covariance Systems, Xinhua Zhou, Tian Gao, Yunchao Pang, Hayden Mahan, Xiufen Li, Ning Zheng, Andrew E. Suyker, Tala Awada, Jiaojun Zhu

School of Natural Resources: Faculty Publications

Field CO₂ /H₂O measurements from infrared gas analyzers in closed-path eddy-covariance systems have wide applications in earth sciences. Knowledge about exactness of these measurements is required to assess measurement applicability. Although the analyzers are specified with uncertainty components (zero drift, gain drift, cross-sensitivities, and precision), exactness for individual measurements is unavailable due to an absence of methodology to comprehend the components as an overall uncertainty. Adopting an advanced definition of accuracy as a range of all measurement uncertainty sources, the specified components are composited into a model formulated for studying analyzers’ CO₂ /H₂O accuracy …

Identification Of Bacterial Wilt (Erwinia Tracheiphila) Resistances In Usda Melon Collection, Bimala Acharya, Lucas Mackasmiel, Ali Taheri, Christine A. Ondzighi-Assoume, Yiqun Weng, C. Korsi Dumenyo

Agricultural and Environmental Sciences Faculty Research

Bacterial wilt (BW) caused by the Gram-negative bacterium, Erwinia tracheiphila (Et.), is an important disease in melon (Cucumis melo L.). BW-resistant commercial melon varieties are not widely available. There are also no effective pathogen-based disease management strategies as BW-infected plants ultimately die. The purpose of this study is to identify BW-resistant melon accessions in the United States Department of Agriculture (USDA) collection. We tested 118 melon accessions in two inoculation trials under controlled environments. Four-week-old seedlings of test materials were mechanically inoculated with the fluorescently (GFP) labeled or unlabeled E. tracheiphila strain, Hca1-5N. We recorded the number of days to …

Paliperidone 3-Month Injection For Treatment Of Schizophrenia: A Narrative Review, Amber N. Edinoff, Prithvi K. Doppalapudi, Claudia V. Orellana, Caroline Ochoa, Shelby J. Patti, Yahya A. Ghaffar, Elyse M. Cornett, Aaron J. Kaye, Omar Viswanath, Ivan Urits, Adam M. Kaye, Alan David Kaye

School of Pharmacy Faculty Articles

Given the typical age onset of schizophrenia, there are tremendous economic and social impacts that extend beyond the person and their families. One critical determinant of the diseases' impact is the patient's adherence to antipsychotic drug treatment. Approved in 2015 for the treatment of schizophrenia, paliperidone palmitate (Invega Trinza, a 3-month injection, noted as PP3M) is a second-generation long-acting injectable antipsychotic medication. Among the different formulations offered for palmitate paliperidone, including the 1 and 3-month formulations, the longer duration 3-month formulation was better at preventing relapse in schizophrenic patients. To date, different formulations of palmitate paliperidone that have been studied …

Using Pet Imaging To Track Sting-Induced Interferon Signaling, Enitome E. Bafor, Howard A. Young

United States Public Health Resources

In the 19th century, Ilya Metchnikoff defined and broadened our initial understanding of phagocytosis and, in 1908, went on to show that a cellular component (i.e., DNA) stimulates immune responses (1). About a century later, Janeway conceptualized pattern recognition receptors (PRRs) and pathogen-associated molecular patterns (PAMPs) (2). Since then, we know that PAMP recognition by innate immune cells via PRRs activates the production of several cytokines, including interferons (IFNs), with the eventual recruitment of lymphocytes. Subsequent research discovered that innate immune recognition of double-stranded DNA (dsDNA) triggers autoimmune diseases (3). However, before the discovery of dsDNA sensors, an endoplasmic reticulum …

Risk Of Hemolytic Uremic Syndrome Related To Treatment Of Escherichia Coli O157 Infection With Different Antimicrobial Classes, Rajal K. Mody, Robert M. Hoekstra, Magdalena Kendall Scott, John Dunn, Kirk Smith, Melissa Tobin-D'Angelo, Beletshachew Shiferaw, Katie Wymore, Paula Clogher, Amanda Palmer, Nicole Comstock, Kari Burzlaff, Sarah Lathrop, Sharon Hurd, Patricia M. Griffin

Pathology Research and Scholarship

Treatment of Shiga toxin-producing Escherichia coli O157 (O157) diarrhea with antimicrobials might alter the risk of hemolytic uremic syndrome (HUS). However, full characterization of which antimicrobials might affect risk is lacking, particularly among adults. To inform clinical management, we conducted a case-control study of residents of the FoodNet surveillance areas with O157 diarrhea during a 4-year period to assess antimicrobial class-specific associations with HUS among persons with O157 diarrhea. We collected data from medical records and patient interviews. We measured associations between treatment with agents in specific antimicrobial classes during the first week of diarrhea and development of HUS, adjusting …

A Machine Learning Interpretation Of The Contribution Of Foliar Fungicides To Soybean Yield In The North‐Central United States, Denis A. Shah, Thomas R. Butts, Spyridon Mourtzinis, Juan I. Rattalino Edreira, Patricio Grassini, Shawn P. Conley, Paul D. Esker

Department of Agronomy and Horticulture: Faculty Publications

Foliar fungicide usage in soybeans in the north-central United States increased steadily over the past two decades. An agronomically-interpretable machine learning framework was used to understand the importance of foliar fungicides relative to other factors associated with realized soybean yields, as reported by growers surveyed from 2014 to 2016. A database of 2738 spatially referenced fields (of which 30% had been sprayed with foliar fungicides) was fit to a random forest model explaining soybean yield. Latitude (a proxy for unmeasured agronomic factors) and sowing date were the two most important factors associated with yield. Foliar fungicides ranked 7th out of …

Multi-Agent Scavenging Patterns In Hawai‘I: A Forensic Archaeological And Skeletal Case Study, Jennifer F. Byrnes, William Belcher

Department of Anthropology: Faculty Publications

Knowledge of the behavior of local fauna can aid forensic investigators in developing awareness of site formation processes. In Hawai‘i, little has been published on the effects of feral domestic pig (Sus scrofa) and feral domestic dog (Canis familiaris) scavenging and bone dispersal on field recovery and laboratory observations. In this Pacific tropical setting, the most consequential terrestrial taphonomic agents are pigs and dogs, both in terms of hard tissue modification and dispersal of remains across the landscape. In 2017, an archaeologist discovered the remains of an unidentified decedent on the island of Kauaʻi, State of Hawai‘i during a cultural …

You’Ve Got Mail: A Sequential Mixed Methods Linguistic Investigation Of Faculty And Advisor Email, Kevin A. Manley

Dissertations

Email is one of the most prolific forms of communication in the world. As colleges and universities move more student experiences online, faculty members and advisors need to understand how to best communicate with students. In an attempt to understand how faculty and advisors write, and, more importantly, how students read, I developed this two-phase mixed methods investigation. In Phase I, I collected nine writing samples from 19 faculty and advisor participants and dissected the samples with Pennebaker Conglomerate’s 2015 Linguistic Inquiry and Word Count (LIWC) program. In a transition phase, I leveraged Phase I data to create an instrument …

Punnett Square Or Protein Production? The Expert-Novice Divide For Conceptions Of Genes And Gene Expression, Dina L. Newman, Aeowynn Coakley, Aidan Link, Korinne Mills, Leslie Kate Wright

Articles

Concepts of molecular biology and genetics are difficult for many biology undergraduate students to master yet are crucial for deep understanding of how life works. By asking students to draw their ideas, we attempted to uncover the mental models about genes and gene expression held by biology students (n = 23) and experts (n = 18) using semistructured interviews. A large divide was identified between novice and expert conceptions. While experts typically drew box-and-line representations and thought about genes as regions of DNA that were used to encode products, students typically drew whole chromosomes rather than focusing on gene structure …