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Analysis Of Potentially Toxic Contaminants In Milk Powder, Magdalena Mititelu, Lucian Hîncu, Emma Adriana Ozon, Daniela Luiza Baconi, Ioana Paunica, Oana Denisa Bălălău

Journal of Mind and Medical Sciences

The aim of this study was to identify potentially toxic contaminants in milk powder. Powdered milk contains a range of toxic and non-toxic substances that are present in a wide variety, also having very different origins. A number of seven milk powder samples from different producers sold on the Romanian market were analyzed, the samples that were collected from the original packaging: P1, P 2, P3, P4, P5, P6 and P7. The concentration of the following elements was analyzed using the X-ray (XRF) fluorescence method: potassium (K), chlorine (Cl), calcium (Ca), phosphorus (P) and aluminum (Al). The vast majority of …

Intestinal Dysbiosis – A New Treatment Target In The Prevention Of Colorectal Cancer, Florinela-Andrada Dumitru, Sergiu Ioan Micu, Roxana Emanuela Popoiag, Marilena Musat, Andreea Daniela Caloian, Valentin Calu, Vlad Denis Constantin, Daniela Gabriela Balan, Cornelia Nitipir, Florin Enache

Journal of Mind and Medical Sciences

The gastrointestinal microbiome contains at least 100 trillion microorganisms (bacteria, viruses, fungi), whose distribution varies from the mouth to the rectum spatially and temporally throughout one's lifetime. The microbiome benefits from advancing research due to its major role in human health. Studies indicate that its functions are immunity, metabolic processes and mucosal barrier. The disturbances of these functions, dysbiosis, influence physiology, lead to diabetes, inflammatory bowel disease, obesity and colon tumorigenesis. The third most common form of cancer, colorectal cancer, is the result of many factors and genes, and although the link between dysbiosis and this type of cancer is …

How Opportune Is Multigene Testing In Metastatic Colorectal Cancer? A Review, Cristina Orlov-Slavu, Andreea Parosanu, Mihaela Olaru, Dragos Serban, Ioana Paunica, Cornelia Nitipir

Journal of Mind and Medical Sciences

Personalized treatment in oncology is the most innovative method of care. The best method to establish personalized treatment is by genetic characterization of the malignant cell.

Theoretically, the more detailed the characterization, the more effective the choice of treatment becomes. Currently, there are fast and relatively low-cost options that allow such genetic characterization. However, test results sometimes do not detect targetable alterations and, even if they do detect, the use of the treatment-alteration combination does not always generate a satisfactory oncological response.

The present paper aims to answer two questions. First, how targetable can the most common gene alterations in …

Therapeutic Efficacy Of Mesenchymal Stem Cells For Cardiovascular Diseases, Dragana Radoje Miloradovic, Dragica Radoje Pavlovic, Miodrag Bozidar Stojkovic, Sanja Bratislav Bojic, Vladislav Bogdan Volarevic, Marina Milosav Gazdic Jankovic, Biljana Tomislav Ljujic

Journal of Mind and Medical Sciences

Despite the improvements in pharmacological and surgical treatments, cardiovascular diseases (CVDs) are the number one cause of death worldwide. During the last two decades, the search for new therapies has been revolutionized with the growing knowledge of stem cell biology. Due to their huge differentiation capacity and paracrine effects, mesenchymal stem cells (MSCs) are a promising tool for the treatment of CVDs. The encouraging outcomes of preclinical studies using MSCs as a treatment for diseased myocardium have set the scene for worldwide clinical trials. In this review, we overview either complete or ongoing clinical trials using MSCs for the therapy …

The Molecular Mechanisms Linking Metabolic Syndrome To Endometrial And Breast Cancers, Andrada-Luciana Lazar, Romana Vulturar, Adriana Fodor, Olga Hilda Orasan, Camil-Horia Eusebiu Crișan, Cezar Login, Ioana Para, Vasile Negrean, Brandusa Tiperciuc, Angela Cozma

Journal of Mind and Medical Sciences

The metabolic syndrome represents a plethora of cardio-metabolic risk factors including obesity, arterial hypertension, atherogenic dyslipidemia, hyperglycemia, accompanied by pro-inflammatory and pro-thrombotic state. The metabolic syndrome is one of the key risk factors for certain types of cancer. Among these malignancies, breast cancer and endometrial neoplasms require special attention. Incriminated major causes for the development of breast and endometrial cancer in metabolic syndrome patients are: the pro-inflammatory status and related cytokines, adipokine imbalances, hyperestrogenism, growth factors, disturbances in cancer microenvironment, insulin resistance and hyperinsulinemia. The metabolic syndrome consists of molecular dysregulations that create a pro-oncogenic status. Our review aims at …

Increase Of Genetic Variability Of Forage Arachis By Intra And Interspecific Hybridization, J. M. F. Valls, C. M. Castro, M. A. P. Oliveira, C. C. Teixeira

IGC Proceedings (1977-2023)

This study was conducted to examine the potencial to increase the genetic variability of forage Arachis species, involving crosses between accessions of same species and crosses between different species, mostly of distinct taxonomic sections. Hybrids were produced between creeping, stoloniferous accessions belonging to section Caulorrhizae, Arachis pintoi x A. pintoi and A. pintoi x A. repens. Additional crosses involved section Caulorrhizae versus representatives of Erectoides (A. hermannii and A. paraguariensis) and Procumbentes (A. appressipila, A. kretschmeri, A. lignosa and A. vallsii). In intersectional crosses, the stoloniferous accessions were used as male parents. …

Searching For Molecular Markers For Salt Tolerance In Rhodes Grass (Chloris Gayana Kunth), E. Taleisnik, M. Salgado, M. D. Bonafede, L. E. Manghers, H. Pérez, L. García Seffino, A. Castagnaro, D. G. Díaz

IGC Proceedings (1977-2023)

Rhodes grass (Chloris gayana Kunth), a C4 forage grass, is regarded as salttolerant and exhibits intra- and inter-cultivar variability for this trait. Plants of cv Boma were selected for salt tolerance at the seedling and adult stages, cloned and characterized by RAPD and AFLP amplification patterns. Both techniques were equally efficient for fingerprinting these clones. More bands were obtained by AFLP but the ratio of polymorphic bands and the proportion present only in tolerant clones were the same by both methods. These bands, along with those exclusive for sensitive clones could be useful as markers for assisted selection.

Biotechnological Improvement In Timothy Breeding, S. Pulli, Y. D. Guo

IGC Proceedings (1977-2023)

Biotechnological improvements in timothy breeding by androgenic and somatic cell culture and molecular identification were achieved. The doubled haploid (DH) plants were obtained via anther and microspore culture. A series of factors which affect androgenic embryogenesis and green plant regeneration have been evaluated. The PG-96 induction media which sharply promote androgenic embryogenesis have been established. Over 400 DH plants of timothy were obtained. Timothy somatic callus induction was successfully established using immature inflorescences and seedling stems. Suspension cultures were initiated from friable nodule-forming callus. More than 100 regenerated green plants were obtained from somatic callus and suspension clumps. DNA-based fingerprinting …

Evolutionary Recurrent Selection Develops Adapted Annual Ryegrass, G. M. Prine

IGC Proceedings (1977-2023)

Seed companies find having their own annual ryegrass breeding program in the southeastern USA, unprofitable. The annual ryegrass breeding program at the University of Florida provides new annual ryegrass (Lolium multiflorum) cultivars with disease resistance and adaption. The evolutionary recurrent selection breeding uses large nurseries, roguing of diseased and unthrifty plants and selection of best plants to provide seed for the next generation. Current commercial cultivars developed are named along with some of their characteristics.

Don’T Hold Your Breath: An Analysis Of Georgia’S Dui Implied Consent Law, Melissa Davies

Law Review Blog Posts

After the Georgia Supreme Court’s rulings in Olevik v. State and Elliott v. State, Georgia’s DUI Implied Consent Law continues to perplex prosecutors. This article analyzes and compares these rulings.

Human 5’-Tailed Mirtrons Are Processed By Rnasep, Mohammad Farid Zia

Dissertations

Approximately a thousand microRNAs (miRNAs) are documented from human cells. A third appear to transit non-canonical pathways that typically bypass processing by Drosha, the dedicated nuclear miRNA producing enzyme. The largest class of non-canonical miRNAs are mirtrons which eschew Drosha to mature through spliceosome activity. While mirtrons are found in several configurations, the vast majority of human mirtron species are 5’-tailed. For these mirtrons, a 3’ splice site defines the 3’ end of their hairpin precursor while a “tail” of variable length separates the 5’ base of the hairpin from the nearest splice site. How this tail is removed is …

Localization Of Kisspeptin, Nkb, And Nk3r In The Hypothalamus Of Gilts Treated With The Progestin Altrenogest, Ashley N. Lindo, Jennifer F. Thorson, Michelle N. Bedenbaugh, Richard B. Mccosh, Justin A. Lopez, Samantha A. Young, Lanny J. Meadows, Elizabeth C. Bowdridge, Chrysanthi Fergani, Bradley A. Freking, Michael N. Lehman, Stanley M. Hileman, Clay A. Lents

Roman L. Hruska U.S. Meat Animal Research Center: Reports

Mechanisms in the brain controlling secretion of gonadotropin hormones in pigs, particularly luteinizing hormone (LH), are poorly understood. Kisspeptin is a potent LH stimulant that is essential for fertility in many species, including pigs. Neurokinin B (NKB) acting through neurokinin 3 receptor (NK3R) is involved in kisspeptin-stimulated LH release, but organization of NKB and NK3R within the porcine hypothalamus is unknown. Hypothalamic tissue from ovariectomized (OVX) gilts was used to determine the distribution of immunoreactive kisspeptin, NKB, and NK3R cells in the arcuate nucleus (ARC). Almost all kisspeptin neurons coexpressed NKB in the porcine ARC. Immunostaining for NK3R was distributed …

Assessment Of The Mate Retention Inventory-Short Form Using Item Response Theory, Patrick J. Nebl, Mark G. Mccoy, Garett C. Foster, Michael J. Zickar

Psychology Faculty Publications

The mate retention inventory (MRI) has been a valuable tool in the field of evolutionary psychology for the past 30 years. The goal of the current research is to subject the MRI to rigorous psychometric analysis using item response theory to answer three broad questions. Do the individual items of the MRI fit the scale well? Does the overall function of the MRI match what is predicted? Finally, do men and women respond similarly to the MRI? Using a graded response model, it was found that all but two of the items fit acceptable model patterns. Test information function analysis …

Multi-Organs-On-Chips For Testing Small-Molecule Drugs: Challenges And Perspectives., Berivan Cecen, Christina Karavasili, Mubashir Nazir, Anant Bhusal, Elvan Dogan, Fatemeh Shahriyari, Sedef Tamburaci, Melda Buyukoz, Leyla Didem Kozaci, Amir K Miri

Henry M. Rowan College of Engineering Departmental Research

Organ-on-a-chip technology has been used in testing small-molecule drugs for screening potential therapeutics and regulatory protocols. The technology is expected to boost the development of novel therapies and accelerate the discovery of drug combinations in the coming years. This has led to the development of multi-organ-on-a-chip (MOC) for recapitulating various organs involved in the drug-body interactions. In this review, we discuss the current MOCs used in screening small-molecule drugs and then focus on the dynamic process of drug absorption, distribution, metabolism, and excretion. We also address appropriate materials used for MOCs at low cost and scale-up capacity suitable for high-performance …

The Utah Statesman, October 11, 2021, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

A Systematic Review Of Diet Quality Index And Obesity Among Chinese Adults, Isma'il Kadam, Sudeep Neupane, Jingkai Wei, Lee Ann Fullington, Tricia Li, Ruopeng An, Li Zhao, Amy Ellithorpe, Xinyin Jiang, Liang Wang

Publications and Research

Diet quality scores are designed mainly based on Western-style dietary patterns. They were demonstrated to be good indicators of obesity in developed but not developing countries. Several diet quality scores were developed based on the Chinese dietary guidelines, yet no systematic review exists regarding how they were related to obesity. We searched research articles published between 2000 and 2021 in PubMed, CINAHL, and Scopus databases. Both cross-sectional and prospective studies that examined the relationship between a diet quality score and weight, body mass index, obesity, or waist circumference conducted in a Chinese population were selected. From the 602 articles searched, …

What Kind Of Information Does The Era Of Climate Change Require?, Jo Guldi

History Faculty Publications

This article explores the promise of institutions and infrastructures associated with democ- racy to limit the worst consequences of climate change. The article highlights the appar- ent conflict between expert governance on the one hand, and, on the other hand, calls for democratization that reflect the diverse perspectives of groups whose rights and labor have been exploited over historical timescales. Drawing on the history of bureaucracy and governance, this article argues that the apparent contradiction between the two poles of discourse can be reconciled by a system of information infrastructure designed to cre- ate a robust, accountable system of environmental …

Combatting The Effects Of Greenhouse Gas Emissions By Cattle To Decrease Global Warming, Grace Stockmal

D.U.Quark

Greenhouse gases (GHG), specifically methane, carbon dioxide, and nitrous oxide, contribute to eutrophication and global warming. Large amounts of these gases are released by beef and dairy farms. The misconception is how and why greenhouse gases are emitted from cows. It is hypothesized that greenhouse gas emissions from cattle can be reduced through mitigation strategies in beef and dairy production along with farmers’ contributions to their livestock’s emissions. The reduction of emissions and increase in milk production comes from increased activity and care of the cows, including medicating lesions and diseases. It is also concluded that waste management and records …

Uncovering Disease Mechanisms In A Novel Mouse Model Expressing Humanized Apoeε4 And Trem2*R47h., Kevin P Kotredes, Adrian Oblak, Ravi S Pandey, Peter Bor-Chian Lin, Dylan Garceau, Harriet M. Jackson, Asli Uyar, Rita O'Rourke, Sarah O'Rourke, Cynthia Ingraham, Daria Bednarycek, Melisa Belanger, Zackary Cope, Kate E Foley, Benjamin A Logsdon, Lara M Mangravite, Stacey J Sukoff Rizzo, Paul R Territo, Gregory W. Carter, Michael Sasner, Bruce T Lamb, Gareth R Howell

Faculty Research 2021

Late-onset Alzheimer's disease (AD; LOAD) is the most common human neurodegenerative disease, however, the availability and efficacy of disease-modifying interventions is severely lacking. Despite exceptional efforts to understand disease progression via legacy amyloidogenic transgene mouse models, focus on disease translation with innovative mouse strains that better model the complexity of human AD is required to accelerate the development of future treatment modalities. LOAD within the human population is a polygenic and environmentally influenced disease with many risk factors acting in concert to produce disease processes parallel to those often muted by the early and aggressive aggregate formation in popular mouse …

Mercaptopurine-Loaded Sandwiched Tri-Layered Composed Of Electrospun Polycaprolactone/Poly(Methyl Methacrylate) Nanofibrous Scaffolds As Anticancer Carrier With Antimicrobial And Antibiotic Features: Sandwich Configuration Nanofibers, Release Study And In Vitro Bioevaluation Tests, Samar A. Salim, Elbadawy A Kamoun, Stephen Evans, Shahira H El-Moslamy, Esmail M El-Fakharany, Mohamed M Elmazar, Af Abdel-Aziz, Rh Abou-Saleh, Taher A Salaheldin

Nanotechnology Research Centre

No abstract provided.

Intouch October 11, 2021, New York Medical College

InTouch

• GSBMS Hosts Inaugural Lab Coat Ceremony for Ph.D. Candidates
• Join NYMC at the Founder's Dinner
• Garden Club Hosts Reopening of Rejuvenated Lisa Qian, M.D. '18, Memorial Garden
• NYMC Honored at Doctors of Distinction Virtual Awards Ceremony
• SMHW Offers a Myriad of Mental Health Resources for NYMC Students
• Fifteenth Symposium in the COVID-19 Series Set for October 14
• Doc’s Café Reopens
• Chancellor Halperin Shares His Thoughts on Vaccine Mandates

A Review Of The History Of The Names Hamaticherus Dejean And Plocaederus Dejean And Description Of A New Genus And Species (Coleoptera: Cerambycidae: Cerambycinae), Antonio Santos-Silva, Kimberly García, Juan Pablo Botero

Insecta Mundi

Hamaticherus Dejean, 1821 (Coleoptera: Cerambycidae: Cerambycinae) is considered a junior synonym of Cerambyx Linnaeus, 1758. Hamaticherus sensu Audinet-Serville, 1834 is considered a posterior usage of Hamaticherus Dejean, 1821, and an unavailable name. Plocaederus is considered as a new genus, and not a replacement name, proposed by Dejean (1835) to allocate the species included in Hamaticherus sensu Audinet-Serville, 1834. Therefore, a new genus, Hamaederus Santos-Silva, Garcia and Botero, is herein pro­posed to include the species currently allocated in Plocaederus Dejean, 1835, creating 15 new combinations, and additionally, a new species from French Guiana, Hamaederus allofasciatus Santos-Silva, Garcia and Botero, …

First Reports Of Species-Specific Ant Resemblance In Heteronotine Treehoppers (Hemiptera: Membracidae: Heteronotinae), Robert Perger

Insecta Mundi

Species-specific ant resemblance in heteronotine membracids (Hemiptera: Membracidae) is re­ported for the first time, providing evidence for ant mimicry. The shape, integument color and shine of the pronotal process of females of Heteronotus fabulosus Boulard closely resemble workers of the co-occurring giant turtle ant Cephalotes atratus (Linnaeus) (Hymenoptera: Formicidae). The entire membracid appears to mimic a mutualistic relationship between a membracid and a turtle ant.

The treehopper family Membracidae Rafinesque, 1815 is famous among entomologists for their mutualistic rela­tionships with hymenopterans (Way 1963) and high morphological diversity of their pronotum, often consisting of brightly colored and/or curiously shaped structures such …

Shaking Up The Immunoglobulin Superfamily, Christopher Mendoza

Theses and Dissertations

The immunoglobulin superfamily (IgSF) is a large protein superfamily of membrane and soluble proteins that influence recognition, binding, and adhesion. Among members of this family are cell adhesion molecules (CAMs), which form cell-cell contact points that play key roles in development, cell polarization, and cellular fate. Cadherins (CADs) are calcium-dependent proteins of the adherens junction (AJ), and polarize epithelium and endothelium. The tight junction (TJ) is a multiprotein junctional complex whose function is to control the permeability of the paracellular pathway. At the membrane level, TJs are composed of three types of proteins: claudins (CLDNs), occludin (OCLN) and junctional adhesion …

Impact Of Feeding Syngenta Enogen® Feed Corn Compared To Control Corn In Different Diet Scenarios To Finishing Beef Cattle, Stacia M. Volk, Hannah H. Wilson, Kathryn J. Hanford, James C. Macdonald, Galen E. Erickson

Department of Animal Science: Faculty Publications

The objective of this pooled statistical analysis was to evaluate Syngenta Enogen® Feed Corn (EFC) versus conventional corn (CON) when fed as either dry-rolled corn (DRC) or highmoisture corn (HMC) for effects on finishing beef cattle performance and carcass characteristics. Corns were evaluated in diets with byproduct inclusion rates of 0, 15, 18, 20, and 30% distiller grains or 25 and 35% Sweet Bran® (a commercial corn gluten feed product). Seven trials (n = 1856) consisting of 200 pen means comparing 26 diet treatments were analyzed using regression in a pooled analysis. When EFC was processed as DRC, the gain …

Ecological Selectivity And The Evolution Of Mammalian Substrate Preference Across The K–Pg Boundary, Jonathan J. Hughes, Jacob S. Berv, Stephen G. B. Chester, Eric J. Sargis, Daniel J. Field

Publications and Research

The Cretaceous–Paleogene (K–Pg) mass extinction 66 million years ago was characterized by a worldwide ecological catastrophe and rapid species turnover. Large-scale devastation of forested environments resulting from the Chicxulub asteroid impact likely influenced the evolutionary trajectories of multiple clades in terrestrial environments, and it has been hypothesized to have biased survivorship in favour of nonarboreal lineages across the K–Pg boundary. Here, we evaluate patterns of substrate preferences across the K–Pg boundary among crown group mammals, a group that underwent rapid diversification following the mass extinction. Using Bayesian, likelihood, and parsimony reconstructions, we identify patterns of mammalian ecological selectivity that are …

Diffusional Fractionation Of Helium Isotopes In Silicate Melts, Haiyang Luo, Bijaya Karki, Dipta B. Ghosh, Huiming Bao

Faculty Publications

Estimating Helium (He) concentration and isotope composition of the mantle requires quantifying He loss during magma degassing. The knowledge of diffusional He isotope fractionation in silicate melts may be essential to constrain the He loss. Isotopic mass dependence of He diffusion can be empirically expressed as D3He/D4He = (4/3)^β, where D is the diffusivity of a He isotope. However, no studies have reported any β values for He in silicate melts due to technical challenges in both experiments and computations. Here, molecular dynamics simulations based on deep neural network potentials trained by ab initio data …

A Roadmap For Building Data Science Capacity For Health Discovery And Innovation In Africa, Joseph Beyene, Solomon W. Harrar, Mekibib Altaye, Tessema Astatkie, Tadesse Awoke, Ziv Shkedy, Tesfaye B. Mersha

Statistics Faculty Publications

Technological advances now make it possible to generate diverse, complex and varying sizes of data in a wide range of applications from business to engineering to medicine. In the health sciences, in particular, data are being produced at an unprecedented rate across the full spectrum of scientific inquiry spanning basic biology, clinical medicine, public health and health care systems. Leveraging these data can accelerate scientific advances, health discovery and innovations. However, data are just the raw material required to generate new knowledge, not knowledge on its own, as a pile of bricks would not be mistaken for a building. In …

Emerging Evidence On The Effects Of Dietary Factors On The Gut Microbiome In Colorectal Cancer, Muni Rubens, Venkataraghavan Ramamoorthy, Anshul Saxena, Raees Tonse, Peter Mcgranaghan, Adeel Kaiser, Rupesh Kotecha

All Publications

Dietary factors play an important role in shaping the gut microbiome which, in turn, regulates the molecular events in colonic mucosa. The composition and resulting metabolism of the gut microbiome have been implicated in the development of colorectal cancer (CRC). Diets low in dietary fibers and phytomolecules as well as other lifestyle-related factors may predispose to CRC. Emerging evidence demonstrates that the predominance of microbes, such as Fusobacterium nucleatum, can predispose the colonic mucosa to malignant transformation. Dietary and lifestyle modifications have been demonstrated to restrict the growth of potentially harmful opportunistic organisms. In this study, we aim to present …

Crow's Nest, October 11, 2021, Crow's Nest Staff

Crow's Nest

The October 11, 2021, issue of the Crow's Nest.