Digital Commons Network^™

Role Of Autophagy In Acridocarpus Orientalis-Induced Anti-Breast Cancer Activity, Suhib Hisham Ahmed Saeed Altabbal

Theses

Breast cancer is the most frequently diagnosed cancer in women worldwide. Triple Negative Breast Cancer (TNBC), which lacks the expression of the hormonal Estrogen Receptor (ER) and Progesterone Receptor (PR), and the amplification of Human Epidermal Growth Factor Receptor 2 (HER2), is not responsive to the hormonal therapy. Therefore, chemotherapy and radiotherapy, which cause severe side effects, are the current available choices to treat TNBC. Hence, there is an urgent need to find new therapeutic choices for TNBC. It is estimated that 50% of all drugs in clinical use during the 21^st century are natural products and plants derived. …

Preparation And Evaluation Of Crocetin-Coated Biodegradable Polymer On Top Of Magnetite Nanoparticles For Their Anticancer Effects, Sulafa Saeed Abdelhalim

Theses

Liver cancer is still one of the leading causes of cancer-related deaths worldwide. This is due to many reasons including lack of effective drugs, late diagnosis of this type of cancer due to the overlapping of symptoms with many other liver diseases, and lack of effective screening tests. Targeted drug delivery systems offer many promising advantages compared to conventional chemotherapy. Targeted delivery will mitigate the bad side effects of chemotherapy such as drug resistance, low therapeutic value since the drug mostly will be administered through an IV affecting healthy and cancer cells alike, and that leads us to an important …

Health - Promoting Benefits (Antioxidants, Antihypertensive, Antidiabetic) And Probiotic Survivability Of Fermented Camel Milk After In - Vitro Digestion By Infogest 2.0: Comparative Study With Fermented Bovine Milk, Ahlam Faisal Al Hammadi

Theses

This study investigated probiotic survival and biological functionality of the bio accessible fraction of fermented Camel milk (FCM) and fermented Bovine milk (FBM) after in - vitro digestion using INFOGEST 2.0 model. Both Camel and Bovine milk were fermented by starter culture only (SC), probiotic Lactococcus lactis (Pro), and a mixture of SC+Pro followed by storage for 21 days. The obtained water - soluble extract (WSE), excreta, and bio accessible fraction during the in - vitro digestion were assessed for it's health benefits. The probiotic survival, proteolysis rate, antioxidant activities, ability to inhibit Į - Amylase and Į - Glucosidase, …

Plankton Dynamic At Eastern Arabian Gulf And Sea Of Oman, Muzna Mohammed Husam Saeed Al Junaibi

Theses

The present study is part of the collaborative research project entitled “Comparative Analysis and Predictions of Algal Blooms in the Arabian Gulf and the Sea of Oman”, between the United Arab Emirates University and Sultan Qaboos University (Grant # G00002684- 31S321), in which simultaneous and intensive biweekly plankton and water samples were collected from two opposite coastal stations off the Strait of Hormuz with the aim to study plankton dynamics at the Arabian Gulf and the Sea of Oman and the effect of environmental parameters on their community structures during the period from May 2018 until May …

Response Of Five Chenopodium Quinoa Varieties To Different Salinity Levels, Elevated Co₂ And Uvb, Saif Ali Matar Al Blooshi

Theses

Ecosystems have been affected by climate changes. Both agriculture and environmental changes are correlated with various features since climate change is the main cause of abiotic and biotic stress which affects crop plants. The climate changes and their severe impact on plant productivity showed great intensities due to the effects of abiotic stress. In the present investigation, five quinoa varieties viz KAUST- 05395/CHFN-68 (V1), KAUST-05398/PI-614889 (V2), KAUST-05397/PI-614885 (V3), KAUST-05403/ICBA-Q3 (V4), and KAUST-05399/PI-614888 (V5) were screened for their salinity stress response by measuring the morphological parameters such as total plant height, fresh and dry weight of shoot and roots. V4 and …

Biosensor Devices Based On Graphene And 2d Materials, Suhada Aidrous Poovathy

Theses

Nanomaterials offered new improvements and developments to the bio-sensing field due to their unique physical and chemical properties. Unique and exceptional electronic properties, such as the ultrahigh surface-to-volume ratio and the excellent electrical properties of the 2D materials like in graphene, making these materials promising for future smaller and faster electronics, but an extensive amount of research is still needed. This thesis is concerned with the study of the integration of 2D material graphene in the development of sensitive and rapid biosensors. The main objective of this thesis is to understand the features and characteristics of graphene, evaluate the scope …

Abiotic Stress Effect On Growth And Photosynthetic Characteristics In Emirati Date Palm Varieties, Nasser Abdullah Ghdayer Al Kaabi

Theses

Plants are naturally exposed to various environmental stresses that affect their growth and development. As a desert plant, date palm has developed strategies to protect itself from most abiotic stresses. However, projected climate changes and the interaction between the various abiotic stressors will have profound effects on date palm adaptation and production. In the present study, five date palm cultivars, namely Chichi, Kalas, Nabt Saif, Sultana and Zamli, were initially evaluated for salinity tolerance by measuring the growth parameters such as plant height, fresh weight and dry weight of shoots and roots. Based on the obtained results, Sultana and Zamli …

Aqueous Wastewater Treatment With Aluminium Oxide, Silicon Dioxide And Alginite, Anifat Adenike Bankole

Theses

Wastewater, regardless of the source, has always found its way into the environment. If not treated it can pose a threat to the life of humans as well as aquatic organisms. In regard to the treatment of wastewater containing remnant organic dyes, the adsorption of these on recyclable sorbent materials such as alginite, alumina, and silica gel was evaluated. The main objective of this thesis is to evaluate the sorption process for dye tainted water specifically stemming from educational and research laboratories. Adsorption studies of the wastewater with sorbent materials were carried out under different experimental conditions. The study investigates …

Analysis Of The 16s Rrna For The Identification Of Microbial Communities In The Rhizosphere Of Cultivated Date Palms Trees Under Salt Stress Condition In The Uae Ecosystem, Azra Issa Shamim

Theses

Increasing soil salinity is an emerging global issue, generating land degradation, affecting agricultural production and further affecting quality of ground water. In arid environment with water scarcity, saline ground water has been regularly used for irrigation purpose in date palm (Phoenix dactylifera) plantation, without knowing its impact on their root-associated bacterial communities. The aim of this study is to investigate the impact of saline water irrigation on date palm root-associated bacterial community compositional structure and their diversity. Plant root samples were collected from date palm farms located in Abu Dhabi Emirate, irrigated with either saline, or non-saline water. Overall, we …

Livestock Ticks In The Uae: Prevalence, Distribution, Population Dynamics, And Associated Microorganisms, Nighat Perveen

Dissertations

Ticks are important vectors of an array of viral, bacterial, and protozoan pathogens resulting in a wide range of animal and human diseases in the Middle East and North Africa (MENA). In this study, ticks were collected from camels, cows, sheep, and goats in Abu Dhabi, Dubai, and Sharjah in the United Arab Emirates (UAE). The objectives of the study were to (1) identify tick species of livestock through taxonomic keys and using molecular markers, and determine their prevalence and distribution in the UAE, (2) assess Hyalomma dromedarii seasonal population fluctuation over a year under common camel breeding and management …

Molecular Mechanism Of Action Of The Natural Polyphenolic Compound And The P300 Inhibitor “Carnosol” Against The Triple Negative Breast Cance, Halima Ali Mohammed Salem Alsamri

Dissertations

Carnosol, a naturally occurring Phyto polyphenol found in sage, oregano, and rosemary, has been extensively studied by our laboratory for its anticancer effects in various types of cancer. In human Triple-Negative Breast Cancer (TNBC), carnosol was shown to inhibit cellular viability, colony growth, induced cell cycle arrest, autophagy, and apoptosis. Nonetheless, very little is known about the molecular mechanism of action. In the current study, the ability of carnosol to inhibit metastasis and tumour growth was examined. Wound healing and invasion assays revealed that carnosol inhibited migration and invasion at non-cytotoxic concentrations of MDA-MB-231 cells. Also, carnosol was found to …

Investigating The Impact Of Pogil-Based Instruction Versus Lecturing Based Instruction On Grade 12 Performance In Circular Motion Unit, Self-Efficacy, And Attitudes, Saif Saeed Al Neyadi

Dissertations

This dissertation aims to investigate the impact of Process Oriented Guided Inquiry Learning (POGIL)-based instruction versus lecture-based instruction on Grade 12 students’ performance in circular motion unit, self-efficacy, and attitudes. Four research questions guided the study. A quasi-experimental, pretest-posttest design was adopted as a methodology to investigate and assess the impact of POGIL-based instruction versus lecture-based instruction on students’ performance as measured by three types of cognitive outcomes; Knowing, Applying and Reasoning (KAR). Two government high schools in Alain were selected as research sites, one for the boys and one for the girls. The total number of participants was approximately …

The Influence Of United Arab Emirates National Culture On Leadership Styles In Higher Education Institutions, Hamsa Saleh Al Ammari

Dissertations

Academic institutions and universities are complicated organizations led by professionals and academics who owe their knowledge and skills to their experience in education and leadership. In a country like the United Arab Emirates (UAE), education leaders who come from different cultural backgrounds practice their daily duties within a context where the local national culture imposes certain assumptions, beliefs, norms, and attitudes on them, thereby controlling their understanding of leadership and shaping their behavior. There has been little academic research into what constitutes the national culture of the UAE, a young, cosmopolitan amalgamation of seven Emirates, viewed internationally as an Arab, …

Adsorption Of Perfluorooctanoic Acid (Pfoa) And Perfluorooctanesulfonic Acid (Pfos) By Aluminum-Based Drinking Water Treatment Residuals, Zhiming Zhang, Dibyendu Sarkar, Rupali Datta, Yang Deng

Michigan Tech Publications, Part 1

Per- and polyfluoroalkyl substances (PFAS) represent a family of emerging persistent organic pollutants. Cost-effective remediation of PFAS contamination via chemical or biochemical degradation is challenging due to their extremely high stability. This study reports the removal of two representative PFAS species, perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS), from water by adsorption using aluminum-based water treatment residuals (Al-WTR), a non-hazardous waste generated during the process of drinking water treatment by alum salts. Rapid adsorption of PFOA and PFOS onto Al-WTR followed a pseudo 2nd order kinetic pattern. Lower pH facilitated the adsorption process with a faster adsorption rate and greater …

An Investigative Analysis Of Underlying Alzheimer’S Disease Pathology: Understanding The Pathology Of Neurofibril Tangles, William Barker

Senior Honors Theses

Researchers familiar with Alzheimer’s Disease (AD) refer to two common pathological hallmarks: β-amyloid plaques and Neurofibril Tangles (NFTs). The development of these pathologies are the leading theory to explain the cause of cognitive decline and dementia-like symptoms of individuals with AD. The literature supports the theory that NFTs are caused by the hyperphosphorylation of the precursor tau protein. However, the mechanism that causes this hyperphosphorylation is still unknown. This review seeks to evaluate the normal function of tau then analyze and expound upon the current research concerning the underlying mechanisms for the hyperphosphorylation of tau observed in Neurofibril Tangles pathologies. …

Intracorporeal And Extracorporeal Anastomosis For Robotic-Assisted And Laparoscopic Right Colectomy: Short-Term Outcomes Of A Multi-Center Prospective Trial, Robert K. Cleary, Matthew Silviera, Tobi J. Reidy, James Mccormick, Craig S. Johnson, Patricia Sylla, Jamie Cannon, Henry Lujan, Andrew Kassir, Ron Landmann, Wolfgang Gaertner, Edward Lee, Amir Bastawrous, Ovunc Bardakcioglu, Sushil Pandey, Vikram Attaluri

Department of Surgery Faculty Research

Background: Studies to date show contrasting conclusions when comparing intracorporeal and extracorporeal anastomoses for minimally invasive right colectomy. Large multi-center prospective studies comparing perioperative outcomes between these two techniques are needed. The purpose of this study was to compare intracorporeal and extracorporeal anastomoses outcomes for robotic assisted and laparoscopic right colectomy. Methods: Multi-center, prospective, observational study of patients with malignant or benign disease scheduled for laparoscopic or robotic-assisted right colectomy. Outcomes included conversion rate, gastrointestinal recovery, and complication rates. Results: There were 280 patients: 156 in the robotic assisted and laparoscopic intracorporeal anastomosis (IA) group and 124 in the robotic …

Massachusetts High School Teachers’ Perceptions Of Transitions In Teaching And Assessment Related To The Next Generation Science Standards, Alyssa Mocharnuk

All Theses And Dissertations

The experiences and perceptions of high school science teachers with the transitions in teaching and assessment related to the adoption of the 2016 Massachusetts Science and Technology/Engineering Framework based on the Next Generation Science Standards were studied in this interpretative phenomenological analysis. The Next Generation Science Standards incorporated both traditional disciplinary content ideas and the new science and engineering practices (NGSS Lead States, 2013). Teachers were required to develop new materials, and difficulty in developing new ways of teaching and assessing science (Friedrichsen and Barnett, 2018; Kawasaki and Sandoval, 2020; Wilde, 2018) was exacerbated by the delay in high-stakes testing …

The San1 Ubiquitin Ligase Avidly Recognizes Misfolded Proteins Through Multiple Substrate Binding Sites, Rebeca Ibarra, Heather R. Borror, Bryce Hart, Richard G. Gardner, Gary Kleiger

Chemistry and Biochemistry Faculty Research

Cellular homeostasis depends on robust protein quality control (PQC) pathways that discern misfolded proteins from functional ones in the cell. One major branch of PQC involves the controlled degradation of misfolded proteins by the ubiquitin-proteasome system. Here ubiquitin ligases must recognize and bind to misfolded proteins with sufficient energy to form a complex and with an adequate half-life to achieve poly-ubiquitin chain formation, the signal for protein degradation, prior to its dissociation from the ligase. It is not well understood how PQC ubiquitin ligases accomplish these tasks. Employing a fully reconstituted enzyme and substrate system to perform quantitative biochemical experiments, …

Growing Faba Beans On The South Coast Of Western Australia, Sarah Belli, Carla Milazzo, Emma Pearse, King Yin Lui, Grace Williams, Jeremy Lemon

Grain and other field crops published reports

Editors: Megan Abrahams, Andrew Blake and Vanessa Stewart (DPIRD)

Foreword

Thirty-three years ago I started work in Esperance on broadleaf crops. One of the best things my boss set up for me was arranging visits with several lupin farmers so I could follow their crops from seeding, through the growing season, to harvest. It was a great way to quickly get an idea of the choices farmers make and the reasons why.

With today’s busy lives, most farmers would be hard pressed to have the luxury of visiting many other farmers multiple times to learn how to grow a crop. …

Perceptions Of The Impact Of Cultural Awareness Training On Southern Municipalities And Their Communities, Charles Robert Love Ii

Doctoral Dissertations and Projects

The overall purpose of this qualitative phenomenological study is to explore the perception of the impact of Cultural Awareness Training toward improving the negative relationship that exists between southern municipalities and their communities, especially those individuals who are culturally different from the given officer(s). In many cases, these relationships involve abuse of power which leads to mutual disrespect and a subsequently diminished relationship. A review of the literature on community-oriented policing provided vivid descriptions with clear examples regarding what is identified as relationship-based policing. Relationship-based policing seeks to get not only the community’s input, but also community involvement in establishing …

Counseling Women In Prison On Forgiveness, Guilt, And Shame, Lashawnda Denise Key

Doctoral Dissertations and Projects

There is a lack of adequate counseling on forgiveness, guilt, and shame in the women’s prison. Without effective counseling on those subjects while incarcerated, there is potential for the female offender to reoffend. Adequate counseling could increase the recidivism rate. Counselors in the prison system address behavior issues, acclimation of prison life and rehabilitation programs. Addressing the issues that precipitates criminal behavior and helping the offender understand the factors that lead them to engage in criminal behavior are overly complex. With passable counseling the offenders have the propensity to release the hurt and pain they have lived with and become …

The Effect Of Forgiveness Training In The Attitude Of Forgiveness In Married Couples, Calo Gobea Yarelie

Doctoral Dissertations and Projects

This study evaluated the impact on the attitude of forgiveness in married couples participating in a 3-hour forgiveness group that incorporates Everett Worthington’s Forgiveness Model: REACH (Worthington, 2008). The study measured the impact of the REACH-based curriculum from Become a More Forgiving Person in Less Than Two Hours (Worthington, 2020) in 32 couples attending the forgiveness class. The study used a quantitative approach/correlational design exploring the relationship between participation in a forgiveness class and attitude towards forgiveness. The focus was on measuring whether program participation increases an attitude of forgiveness and if the couple’s reported satisfaction influenced the attitude of …

Teachers' Perceptions, Awareness, And Responses To Students With Childhood Trauma, Jonathan James Tomlin

Doctoral Dissertations and Projects

The role of trauma-informed education is becoming a topic of discussion for many school leaders and administrators during the COVID-19 pandemic. The purpose of this study was to explore the relationship between trauma training, education, experience, and teacher self-efficacy, and teachers’ self-reported perceptions of student behavior, teaching, and managing behaviors of students with trauma history. Previous research highlighted a lack of teacher input when developing trauma-informed education within school settings. This correlational study investigated factors associated with educator trauma training, education, experience, and self-efficacy. Data were collected from a city school system in a large, urban district in the northeast …

The Effects Of Deployments On Alcohol Use, Stress, Mental Health, And Help-Seeking Behaviors In Military Spouses, Joanne Lorraine Coddington

Doctoral Dissertations and Projects

Operation Iraqi Freedom and Operation Enduring Freedom have kept the United States military engaged in one of the longest wars in the nation’s history. Due to the high operations tempo during that time, both service members and their spouses have endured enormous difficulties as they learned to navigate the challenges brought forth by frequent deployments. The purpose of this research study was to study the alcohol consumption, mental health, stress, and help seeking behaviors of military spouses who have endured deployments, with the hypothesis that alcohol use will not increase during deployment, military spouses will report poorer mental health and …

Student Autonomy And Self-Direction In The Secondary Flipped Chemistry Classroom, Sharon Beaudoin Farrell

Doctoral Dissertations and Projects

The purpose of this collective case study was to describe the student-autonomous learning experiences of secondary chemistry students actively engaged in classrooms utilizing a flipped classroom approach (FCA). The FCA is a pedagogical framework that includes asynchronous, student-paced experiences outside the classroom and face-to-face active learning activities during class meeting times. The theories guiding this study were self-regulated learning and self-determination theory which emphasize the construction of knowledge through shared experiences to support student self-efficacy in the learning process. Participants included students bounded within first-year chemistry classrooms at the honors and college preparatory levels. Data collected from student questionnaires, semi-structured …

Understanding Blended Family Stability: A Phenomenological Study, Marion F. Travers

Doctoral Dissertations and Projects

Most remarriages and blended families dissolve within 1-5 years, and last an average of 3.05 years. The factors that contribute to their dissolution have been defined well in the literature; however, specific protective factors that lead to blended family stability have not. In this study, ‘blended family stability’ refers to individual participants who have remained in their blended family for more than five years and reported more positive than negative factors. This study sought to define the nuclear family and the blended family, and highlight the vast differences across blended families by (1) examining the challenges experienced in remarriage and …

A Case Study Investigation: Student's Perceptions Of Preferential Treatment Of Student-Athletes, Darrin Scott Tipton

Doctoral Dissertations and Projects

The purpose of this exploratory case study was to understand students’ perceptions of teachers’ preferential treatment of high school student-athletes at two Georgia high schools using a multiple case design. Social cognitive theory and the social identity theory guided this study as they relate to high school students’ perceptions of the treatment of student-athletes by classroom teachers. The participants were seniors from two north Georgia high schools who were asked to complete a demographic survey. Purposeful sampling was used to select four student-athletes and four non-student-athletes from each school that then participated in interview sessions and created documentation in the …

A Causal-Comparative Study Of The Effect Of Parental Involvement On The Academic Achievement Of Students In A Georgia High School, Sharon S. Johnson

Doctoral Dissertations and Projects

The purpose of this causal comparative study was to establish the effect parental involvement had on academic achievement of students in a Georgia high school and to determine which type of parental involvement had a greater effect on the academic achievement for those students. This study was important because there was limited research that revealed the effect parental involvement had on academic achievement in a high school setting. This study followed a causal comparative research design and used a convenience sampling method which included 100 students and their parents, 64.9% African Americans, 14.9% Caucasians, and 8.5% Hispanic. Parental involvement was …

Investigating Black Silicon Surface Geometry Via Parameter Modification And Low Flow Inductively Coupled Plasma Deep Reactive Ion Etching, Noah Mulherin Smith

Honors Capstones

No abstract provided.

Comparing Expression And Localization Of Syntaxin-1a And The Cystic Fibrosis Transmembrane Regulator In Adult Gallus Gallus Retinas, Rachel Lauren Butz

Honors Capstones

No abstract provided.