Digital Commons Network^™

A Prospective Examination Of Sex Differences In Posttraumatic Autonomic Functioning., Antonia V Seligowski, Elizabeth R Steuber, Rebecca Hinrichs, Mariam H Reda, Charis N Wiltshire, Cassandra P Wanna, Sterling J Winters, Karlye A Phillips, Stacey L House, Francesca L Beaudoin, Xinming An, Jennifer S Stevens, Donglin Zeng, Thomas C Neylan, Gari D Clifford, Sarah D Linnstaedt, Laura T Germine, Kenneth A Bollen, Guia Guffanti, Scott L Rauch, John P Haran, Alan B Storrow, Christopher Lewandowski, Paul I Musey, Phyllis L Hendry, Sophia Sheikh, Christopher W Jones, Brittany E Punches, Michael C Kurz, Vishnu P Murty, Meghan E Mcgrath, Lauren A Hudak, Jose L Pascual, Mark J Seamon, Elizabeth M Datner, Anna Marie Chang, Claire Pearson, David A Peak, Roland C Merchant, Robert M Domeier, Niels K Rathlev, Brian J O'Neil, Leon D Sanchez, Steven E Bruce, Mark W Miller, Robert H Pietrzak, Jutta Joormann, Deanna M Barch, Diego A Pizzagalli, John F Sheridan, Beatriz Luna, Steven E Harte, James M Elliott, Karestan C Koenen, Ronald C Kessler, Samuel A Mclean, Kerry J Ressler, Tanja Jovanovic

Department of Emergency Medicine Faculty Papers

Background: Cross-sectional studies have found that individuals with posttraumatic stress disorder (PTSD) exhibit deficits in autonomic functioning. While PTSD rates are twice as high in women compared to men, sex differences in autonomic functioning are relatively unknown among trauma-exposed populations. The current study used a prospective design to examine sex differences in posttraumatic autonomic functioning.

Methods: 192 participants were recruited from emergency departments following trauma exposure (

Results: 2-week systolic BP was significantly higher in men, while 2-week HR was significantly higher in women, and a sex by PTSD interaction suggested that women who developed PTSD demonstrated the highest HR …

Making Spatial-Temporal Marine Ecosystem Modelling Better – A Perspective, Jeroen Steenbeek, Joe Buszowski, David Chagaris, Villy Christensen, Marta Coll, Elizabeth A. Fulton, Stelios Katsanevakis, Kristy A. Lewis, Antonios D. Mazaris, Diego Macias, Kim De Mutsert, Greig Oldford, Maria Grazia Pennino, Chiara Piroddi, Giovanni Romagnoni, Natalia Serpetti, Yunne Jai Shin, Michael A. Spence, Vanessa Stelzenmüller

Faculty Publications

Marine Ecosystem Models (MEMs) provide a deeper understanding of marine ecosystem dynamics. The United Nations Decade of Ocean Science for Sustainable Development has highlighted the need to deploy these complex mechanistic spatial-temporal models to engage policy makers and society into dialogues towards sustainably managed oceans. From our shared perspective, MEMs remain underutilized because they still lack formal validation, calibration, and uncertainty quantifications that undermines their credibility and uptake in policy arenas. We explore why these shortcomings exist and how to enable the global modelling community to increase MEMs’ usefulness. We identify a clear gap between proposed solutions to assess model …

Elementary Educator Perceptions Of The Impact Breaks Have On Student Engagement, Sarah-Bo Kirchhoff

Dissertations

According to the US. Department of Labor, 1991, the United States education has shifted the focused to student performance and academic success (NCEE, 2006). School districts across the nation have increased students’ academic demands, including increased academic instruction time, while the allotted time for recess and academic breaks continuously decrease, significantly impacting the school day’s structure (Brusseau & Hannon, 2015; Ginsburg et al., 2007; Stonehill et al., 2011). However, research asserted that instructional time increase does not significantly impact student achievement. In contrast, the increase of academic instruction time could stimulate behavioral problems and sedentary behaviors, while the continuous decrease …

Research News, Publications, 2021, Volume 3, Soumyajit Majumdar

Publications (2015-)

Publications that appeared during the period of July 30 through September 30, 2021

Reducing Catastrophic Forgetting In Self-Organizing Maps, Hitesh Ulhas Mangala Vaidya

Theses

An agent that is capable of continual or lifelong learning is able to continuously learn from potentially infinite streams of pattern sensory data. One major historic difficulty in building agents capable of such learning is that neural systems struggle to retain previously-acquired knowledge when learning from new data samples. This problem is known as catastrophic forgetting and remains an unsolved problem in the domain of machine learning to this day. To overcome catastrophic forgetting, different approaches have been proposed. One major line of thought advocates the use of memory buffers to store data where the stored data is then used …

Silver Bow Creek/Butte Area Npl Site Butte Priority Soils Operable Unit, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Herbal Medicines Registration Process For Zimbabwe Overview Of The Process, Jannet Usai, Z Ekeocha, S Byrn, K Clase

BIRS Africa Technical Report Papers

Unregistered traditional medicines pose a huge public health threat as the safety and efficacy of these products is unknown. The issue this study addresses is the inadequate regulatory measures for herbal medicines in Zimbabwe. This project was done to describe the current registration process of traditional medicines in Zimbabwe, and to identify the gaps and opportunities they present to improve the regulatory landscape. Regulations and laws governing the registration of herbal medicines in the country and published research on legislation of herbal medicines were reviewed. Two parallel regulatory bodies both registering and controlling the sale of herbal medicines were identified. …

Knowledge Sharing In Organisations: Finding A Best-Fit Model For A Regulatory Authority In East Africa, Padde Musa, Z Ekeocha, S Byrn, K Clase

BIRS Africa Technical Report Papers

Knowledge is an essential organisational asset that contributes to organisational effectiveness when carefully managed. Knowledge sharing (KS) is a vital component of knowledge management that allows individuals to engage in new knowledge creation. Until it’s shared, knowledge is considered useless since it resides within the human brain. Public organisations specifically, are more involved in providing and developing knowledge and hence can be classified as knowledge-intensive organisations. Scholarly research conducted on KS has proposed a number of models to help understand the KS process between individuals but none of these models is specifically for a public organisation. Moreover, to really reap …

Improving The Outcome Of Gmp Inspections By Improving Proficiency Of Inspectors Through Consistent Gmp Trainings, Solomon Shiihi, U G. Okafor, Z Ekeocha, S Byrn, K Clase

BIRS Africa Technical Report Papers

Approximately 90% of the pharmaceutical inspectors in a pharmacy practice regulatory agency in West Africa have not updated their training on Good Manufacturing Practice (GMP) inspection in at least eight years. However, in the last two years the inspectors relied on learning-on-the job skills. During this time, the agency introduced about 17% of its inspectors to hands-on GMP trainings. GMP is the part of quality assurance that ensures the production or manufacture of medicinal products is consistent in order to control the quality standards appropriate for their intended use as required by the specification of the product. Inspection reports on …

Compliance To Gmp Guidelines For Herbal Manufacturers In East Africa: A Position Paper, Victoria Kwesiga, Z Ekeocha, S Byrn, K Clase

BIRS Africa Technical Report Papers

With the global increase in the use of traditional and complementary remedies for the prevention and treatment of illness, the quality and safety of these medicines have become a significant concern for all regulatory authorities. Herbal medicines are the most commonly used form of traditional and complementary medicines in the world and the efficacy and safety of herbal medicines, like conventional medicines, largely depends on their quality from planting to harvesting, preprocessing and final processing. Due to the inherent complexity of herbal medicines, often containing an array of active compounds, the primary processing of herbal medicines has a direct influence …

Evaluating And Understanding The Reason For An Increase In Nonconformances In The Laboratory, Andrew Mukungu, Z Ekeocha, S Byrn, K Clase

BIRS Africa Technical Report Papers

This is a study of nonconformances experienced by a laboratory of a pharmaceutical manufacturing facility in East Africa. There has been an increase in nonconformances from 216 nonconformances in 2017 to 229 in 2018 and by September 2019, 306 nonconformances were already logged. Increasing nonconformances result in delayed release of tested materials and many resources are wasted (e.g. chemicals, man hours and equipment). Analysts become frustrated, which may result in inexhaustive investigations. Understanding the reason for the increase in nonconformances will enable the facility to derive effective solutions to the identified causes, hence reducing the number of nonconformances and improving …

Standardisation Of Staff Training To Increase Efficiency, Kikundwa Emma Mbabazi, Z Ekeocha, S Byrn, K Clase

BIRS Africa Technical Report Papers

In any industry or organization, personnel training is emphasized with reference to National Regulatory Authorities (NRAs) guidelines and other globally accepted guidelines. In spite of many refresher training programs, the pharmaceutical industry still faces significant variations in individual/ team efficiency and productivity. Individuals/teams given the same task, SOPs, environment and materials continue to produce significantly different results reflecting the possibility of operating on different sets of theoretical and practical information, which may stem from differing trainer, training program or training method. This study focused on using a standardized manual for training two teams A and B involved in vaccine production, …

Resource Modelling For The Qc Laboratory At Xyz Pharmaceuticals In Southern Africa, Ngonidzashe Portia Munhuweyi, Z Ekeocha, S Byrn, K Clase

BIRS Africa Technical Report Papers

Quality control (QC) laboratories are critical components in drug manufacturing and running them efficiently contributes to better, consistent supply of cost-effective quality products, while also and preventing deaths due to untimely delivery or unavailability of medicines. Having a resource modelling tool to estimate resources needed to handle a particular demand in a given system is essential for efficient running of QC laboratory. This study was done to establish such a model at XYZ Pharmaceuticals. The list of all products manufactured by XYZ Pharmaceuticals Southern Africa was reviewed; and product families for all products were identified. Analysts’ hands on time (HOT) …

Students: Publish In The Jlpha, Edward Trapido

Journal of the Louisiana Public Health Association

No abstract provided.

Student Commentary: Exploring The Role Of White Supremacy In The Pursuit Of Health Equity, Kori Lannaman, Amber Brown

Journal of the Louisiana Public Health Association

No abstract provided.

Vol 2 November '21 Full Issue, Donna L. Williams

Journal of the Louisiana Public Health Association

No abstract provided.

Incarceration Of A Household Member During Childhood And Health-Related Quality Of Life, Amy Hilliker, Andrei Stefanescu

Journal of the Louisiana Public Health Association

No abstract provided.

The Impacts Of Police Raids On Female Strippers In New Orleans, Alexandra Jaoiche, Allie Beth, Jeni Stolow, Gretchen Clum

Journal of the Louisiana Public Health Association

No abstract provided.

Genome-Wide Crispr Interference Screen Identifies Long Non-Coding Rna Loci Required For Differentiation And Pluripotency, Jeffrey R. Haswell, Kaia Mattioli, Chiara Gerhardinger, Philipp G. Maass, Daniel J. Foster, Paola Peinado, Xiaofeng Wang, Pedro P. Medina, John L. Rinn, Frank J. Slack

Dartmouth Scholarship

Although many long non-coding RNAs (lncRNAs) exhibit lineage-specific expression, the vast majority remain functionally uncharacterized in the context of development. Here, we report the first described human embryonic stem cell (hESC) lines to repress (CRISPRi) or activate (CRISPRa) transcription during differentiation into all three germ layers, facilitating the modulation of lncRNA expression during early development. We performed an unbiased, genome-wide CRISPRi screen targeting thousands of lncRNA loci expressed during endoderm differentiation. While dozens of lncRNA loci were required for proper differentiation, most differentially expressed lncRNAs were not, supporting the necessity for functional screening instead of relying solely on gene expression …

A Potential Role For Restricted Intertactical Heritability In Preventing Intralocus Conflict, Madilyn M. Gamble, Ryan G. Calsbeek

Dartmouth Scholarship

Intralocus sexual conflict, which arises when the same trait has different fitness optima in males and females, reduces population growth rates. Recently, evolutionary biologists have recognized that intralocus conflict can occur between morphs or reproductive tactics within a sex and that intralocus tactical conflict might constrain tactical dimorphism and population growth rates just as intralocus sexual conflict constrains sexual dimorphism and population growth rates. However, research has only recently focused on sexual and tactical intralocus conflict simultaneously, and there is no formal theory connecting the two. We present a graphical model of how tactical and sexual conflict over the same …

Bisindolylmaleimide Ix: A Novel Anti-Sars-Cov2 Agent Targeting Viral Main Protease 3clpro Demonstrated By Virtual Screening Pipeline And In-Vitro Validation Assays, Yash Gupta, Dawid Maciorowski, Samantha E. Zak, Krysten A. Jones, Rahul S. Kathayat, Saara-Anne Azizi, Raman Mathur, Catherine M. Pearce, David J. Ilc, Hamza Husein, Andrew S. Herbert, Ajay Bharti, Brijesh Rathi, Ravi Durvasula, Daniel P. Becker, Bryan C. Dickinson, John M. Dye, Prakasha Kempaiah

Chemistry: Faculty Publications and Other Works

SARS-CoV-2, the virus that causes COVID-19 consists of several enzymes with essential functions within its proteome. Here, we focused on repurposing approved and investigational drugs/compounds. We targeted seven proteins with enzymatic activities known to be essential at different stages of the viral cycle including PLpro, 3CLpro, RdRP, Helicase, ExoN, NendoU, and 2′-O-MT. For virtual screening, energy minimization of a crystal structure of the modeled protein was carried out using the Protein Preparation Wizard (Schrodinger LLC 2020-1). Following active site selection based on data mining and COACH predictions, we performed a high-throughput virtual screen of drugs and investigational molecules (n = …

Contributions Made By Undergraduates To Research Projects: Using The Credit Taxonomy To Assess Undergraduate Research Experiences., Matt Honoré, Thomas E. Keller, Jen Lindwall, Rachel Crist, Leslie Bienen, Adrienne Zell

School of Social Work Faculty Publications and Presentations

The authors developed a novel tool, the CREDIT URE, to define and measure roles performed by undergraduate students working in research placements. Derived from an open-source taxonomy for determining authorship credit, the CREDIT URE defines 14 possible roles, allowing students and their research mentors to rate the degree to which students participate in each role. The tool was administered longitudinally across three cohorts of undergraduate student-mentor pairs involved in a biomedical research training program for students from diverse backgrounds. Students engaged most frequently in roles involving data curation, investigation, and writing. Less frequently, students engaged in roles related to software …

The Epidemiology And Incidence Of Dengue In Makkah, Saudi Arabia, During 2017-2019, Sami Melebari, Rowaida Bakri, Abdul Hafiz, Fadel Qabbani, Asim Khogeer, Ismail Alharthi, Sultan Alhazmi, Yehya Almalki, Rasha Bulkhi, Razaz Gammash, Ashwaq Hakim, Ahmed Alkhyami, Mohamed Bazaid, Thanaa Mohammad

Saudi Medical Journal

Objectives: To study the epidemiology of dengue incidence and understand the dynamics of dengue transmission in Makkah, Kingdom of Saudi Arabia (KSA), between 2017-2019. Methods: This is a cross-sectional study. Health and demographic data was obtained for all confirmed dengue cases in Makkah, KSA, in the years 2017-2019 from the Vector-Borne and Zoonotic Diseases Administration (VBZDA) in Makkah and the Makkah Regional Laboratory, KSA. In addition, entomological data about Aedes density was obtained from the VBZDA. Descriptive epidemiological methods were used to determine the occurrence and distribution of dengue cases. Results: Laboratory-confirmed dengue cases were higher in 2019 as compared …

The Effect Of Cerium Oxide On Lung Injury Following Lower Extremity Ischemia-Reperfusion Injury In Rats Under Desflurane Anesthesia, Aycan Ozdemirkan, Aysegul Kucuk, Isin Gunes, Mustafa Arslan, Aydin Tuncay, Volkan Sivgin, Saban C. Sezen, Hakan Boyunaga

Saudi Medical Journal

Objectives: To examine the effects of desflurane and cerium oxide (CO) on lung tissue following ischemia-reperfusion injury (IRI). Methods: Experiments were conducted in Gazi University Animal Laboratory, Ankara, Turkey. Thirty rats were divided into 5 groups: control (C), IRI, IRI-CO, IRI-desflurane (IRID), IRI-CO-desflurane (IRICOD). Cerium oxide was given intraperitoneally. Lower extremity IRI was induced. Desflurane was applied during IRI. Lung histopathological examinations and serum biochemical analyses were performed. Results: Serum nitric oxide (NO) and malondialdehyde (MDA) levels were higher in group IRI ( p =0.006) than in group C ( p =0.001). Serum MDA and NO levels were significantly lower …

The Role Of Precision Agriculture In Food Security, Bruce Erickson, Scott W. Fausti

College of Business Faculty Publications and Presentations

Precision agriculture (PA) is the application of information technology to better manage crop and livestock production, heralded as another tool to advance food security around the world. Precision agriculture has the potential to increase productivity, improve resource allocation for inputs such as pesticides, fertilizers, water, feed, and labor, provide for more stable production, and reduce agricultural production's environmental effect. But PA is an approach that can be very different depending on farm characteristics, such as crops and livestock raised, farm size, management, the farms’ access to technical support, and the characteristics of the operator such as age and education. As …

Property Law For The Ages, Michael C. Pollack, Lior Jacob Strahilevitz

William & Mary Law Review

Within the next forty years, the number of Americans over age sixty-five is projected to nearly double. This seismic demographic shift will necessitate a reckoning in several areas of law and policy, but property law is especially unprepared. Built primarily for young and middle-aged white men, the common law of property has been critiqued for decades for the ways in which it oppresses or simply leaves behind people based on their race, sex, Native heritage, and more. This Article contributes a new focus on property law’s treatment of people based on their advanced age. Burdened by higher relocation costs, more …

Kinematic Assessment Of Turning And Walking Tasks Among Stroke Survivors By Employing Wearable Sensors And Pressure Platform, Masoud Abdollahi, Pranav Madhav Kuber, Christopher Hoang, Michael Shiraishi, Rahul Soangra, Ehsan Rashedi

Physical Therapy Faculty Articles and Research

Stroke survivors often experience reduced movement capabilities due to alterations in their neuromusculoskeletal systems. Modern sensor technologies and motion analyses can facilitate the determination of these changes. Our work aims to assess the potential of using wearable motion sensors to analyze the movement of stroke survivors and identifying the affected functions. We recruited 10 participants (5 stroke survivors, 5 healthy individuals) and conducted a controlled laboratory evaluation for two of the most common daily activities: turning and walking. Among the extracted kinematic parameters, range of trunk and sacrum lateral bending in turning were significantly larger in stroke survivors (p-value<0.02). However, no statistical difference in mean angular velocity and range of motion for trunk/sacrum/shank flexion-extension were obtained in the turning task. Our results also indicated that during walking, while there was no difference in swing time, double support portion of gait among the stroke group was significantly larger (p-value = 0.001). Outcomes of this investigation may help in designing new rehabilitation programs for stroke and other neurological disorders and/or in improving the efficacy of such programs.Clinical Relevance— This study may provide a better insight on the detailed functional differences between stroke survivors and healthy individuals which in turn could be used to develop a more efficient rehabilitation program for stroke community.

Adaptive Immunity: From Autoimmune Diseases To Neuroinflammation, Wei Su

Theses and Dissertations (ETD)

Inflammation is essential for the clearance of pathogens and to facilitate healing of damaged tissue. However, this process must be controlled to limit immunopathology. Cell-intrinsic effects of inhibitory and signaling molecules are known to maintain quiescence and prevent effector differentiation and inflammation. Moreover, specific populations of immune cells exert cell-extrinsic effects for immunosuppression. Therefore, studies on the immunosuppressive functions of these cell populations will provide a better understanding of how inflammation is regulated and how its dysregulation causes human disease. Additional insights in this area may uncover novel targets to be manipulated for therapeutic benefit in autoimmune and inflammatory disorders, …

Open Data Practices Among Users Of Primary Biodiversity Data, Caitlin P. Mandeville

Harold W. Manter Laboratory of Parasitology: Library Materials

Presence-only biodiversity data are increasingly relied on in biodiversity, ecology, and conservation research, driven by growing digital infrastructures that support open data sharing and reuse. Recent reviews of open biodiversity data have clearly documented the value of data sharing, but the extent to which the biodiversity research community has adopted open data practices remains unclear. We address this question by reviewing applications of presence-only primary biodiversity data, drawn from a variety of sources beyond open databases, in the indexed literature. We characterize how frequently researchers access open data relative to data from other sources, how often they share newly generated …

Rooting Out Genetic Structure Of Invasive Wild Pigs In Texas, Anna M. Mangan, Antoinette J. Piaggio, Michael J. Bodenchuk, Courtney F. Pierce, Timothy J. Smyser

United States Department of Agriculture Wildlife Services: Staff Publications

Invasive wild pigs (Sus scrofa), also called feral swine or wild hogs, are recognized as among the most destructive invasive species in the world. Throughout the United States, invasive wild pigs have expanded rapidly over the past 40 years with populations now established in 38 states. Of the estimated 6.9 million wild pigs distributed throughout the United States, Texas supports approximately 40% of the population and similarly bears disproportionate ecological and economic costs. Genetic analyses are an effective tool for understanding invasion pathways and tracking dispersal of invasive species such as wild pigs and have been used recently …