Entire DC Network | Open Access Articles | Digital Commons Network™

Juul 3% Menthol Aerosol Extracts Exhibit Toxicity And Alter Gene Expression Of Murine Macrophages, Samantha Jindia

Honors Capstones

No abstract provided.

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Analysis Of Young, Lineage Specific Alu Elements In Cebus, Catherine Rockwell

Honors Capstones

No abstract provided.

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Murine Trophoblast Stem Cells And Their Differentiated Cells Attenuate Zika Virus In Vitro By Reducing Glycosylation Of The Viral Envelope Protein, Biswas Neupane, Mona Fendereski, Farzana Nazneen, Yanlin Guo, Fengwei Bai

Faculty Publications

Zika virus (ZIKV) infection during pregnancy can cause devastating fetal neuropathological abnormalities, including microcephaly. Most studies of ZIKV infection in pregnancy have focused on post-implantation stage embryos. Currently, we have limited knowledge about how a pre-implantation stage embryo deals with a viral infection. This study investigates ZIKV infection on mouse trophoblast stem cells (TSCs) and their in vitro differentiated TSCs (DTSCs), which resemble the cellular components of the trophectoderm layer of the blastocyst that later develops into the placenta. We demonstrate that TSCs and DTSCs are permissive to ZIKV infection; however, ZIKV propagated in TSCs and DTSCs exhibit substantially lower …

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Regional High-Resolution Benthic Habitat Data From Planet Dove Imagery For Conservation Decision-Making And Marine Planning, Steven R. Schill, Valerie Pietsch Mcnulty, F. Joseph Pollock, Fritjof Lüthje, Jiwei Li, David E. Knapp, Joe D. Kington, Trevor Mcdonald, George T. Raber, Ximena Escovar-Fadul, Gregory P. Asner

Faculty Publications

High-resolution benthic habitat data fill an important knowledge gap for many areas of the world and are essential for strategic marine conservation planning and implementing effective resource management. Many countries lack the resources and capacity to create these products, which has hindered the development of accurate ecological baselines for assessing protection needs for coastal and marine habitats and monitoring change to guide adaptive management actions. The PlanetScope (PS) Dove Classic SmallSat constellation delivers high-resolution imagery (4 m) and near-daily global coverage that facilitates the compilation of a cloud-free and optimal water column image composite of the Caribbean’s nearshore environment. These …

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Next-Generation Ensemble Projections Reveal Higher Climate Risks For Marine Ecosystems, Derek P. Tittensor, Camilla Novaglio, Cheryl S. Harrison, Ryan F. Heneghan, Nicolas Barrier, Daniele Bianchi, Laurent Bopp, Andrea Bryndum-Buchholz, Gregory L. Britten, Matthias Büchner, William W. L. Cheung, Villy Christensen, Marta Coll, John P. Dunne, Tyler D. Eddy, Jason D. Everett, Jose A. Fernandes-Salvador, Elizabeth A. Fulton, Eric D. Galbraith, Didier Gascuel, Jerome Guiet, Jasmin G. John, Jason S. Link, Heike K. Lotze, Olivier Maury, Kelly Ortega-Cisneros, Juliano Palacios-Abrantes, Colleen M. Petrik, Hubert Du Pontavice, Jonathan Rault, Anthony J. Richardson, Lynne Shannon, Yunne-Jai Shin

Faculty Publications

AbstractProjections of climate change impacts on marine ecosystems have revealed long-term declines in global marine animal biomass and unevenly distributed impacts on fisheries. Here we apply an enhanced suite of global marine ecosystem models from the Fisheries and Marine Ecosystem Model Intercomparison Project (Fish-MIP), forced by new-generation Earth system model outputs from Phase 6 of the Coupled Model Intercomparison Project (CMIP6), to provide insights into how projected climate change will affect future ocean ecosystems. Compared with the previous generation CMIP5-forced Fish-MIP ensemble, the new ensemble ecosystem simulations show a greater decline in mean global ocean animal biomass under both strong-mitigation …

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Development Of An Open Hardware 3-D Printed Conveyor Device For Continuous Cryopreservation Of Non-Batched Samples, Yue Liu, Melissa Eskridge, Amy Guitreau, Jacob Beckham, Megan Chesnut, Leticia Torres, Terrence R. Tiersch, William Todd Monroe

Faculty Publications

A great challenge among communities participating in germplasm repository development is to obtain suitable cryopreservation equipment and devices. Commercial programmable freezers are costly and thus unaffordable to many users. Self-made devices have substantial variability, resulting in few opportunities for standardization across communities. The development of open hardware with the increasing accessibility of three-dimensional (3-D) printing offers rapid prototyping and easy fabrication of devices by users around the world at low cost. The present study explored the feasibility of developing operational prototypes of 3-D printed motorized cryopreservation devices for continuous freezing of non-batched samples. A controlled cooling conveyor device (CCCD) was …

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Rickettsia Conorii Survival In Thp-1 Macrophages Involves Host Lipid Droplet Alterations And Active Rickettsial Protein Production, Paige E. Allen, Robert C. Noland, Juan J. Martinez

Division of Basic Science Faculty Publications

Rickettsia conorii is a Gram-negative, cytosolic intracellular bacterium that has classically been investigated in terms of endothelial cell infection. However, R. conorii and other human pathogenic Rickettsia species have evolved mechanisms to grow in various cell types, including macrophages, during mammalian infection. During infection of these phagocytes, R. conorii shifts the host cell's overall metabolism towards an anti-inflammatory M2 response, metabolically defined by an increase in host lipid metabolism and oxidative phosphorylation. Lipid metabolism has more recently been identified as a key regulator of host homeostasis through modulation of immune signalling and metabolism. Intracellular pathogens have adapted mechanisms of hijacking …

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Leptin Treatment Prevents Impaired Hypoglycemic Counterregulation Induced By Exposure To Severe Caloric Restriction Or Exposure To Recurrent Hypoglycemia, Marina A. Duvall, Carolyn E. Coulter, Jasmin L. Gosey, Matthew J. Herrera, Cristal M. Hill, Rajvi R. Jariwala, Lauren E. Maisano, Laura A. Moldovan, Christopher D. Morrison, Ngozi V. Nwabueze, Hunter X. Sikaffy, David H. Mcdougal

Division of Basic Science Faculty Publications

Hypoglycemia-associated autonomic failure (HAAF) is a maladaptive failure in glucose counterregulation in persons with diabetes (PWD) that is caused by recurrent exposure to hypoglycemia. The adipokine leptin is known to regulate glucose homeostasis, and leptin levels fall following exposure to recurrent hypoglycemia. Yet, little is known regarding how reduced leptin levels influence glucose counterregulation, or if low leptin levels are involved in the development of HAAF. The purpose of this study was to determine the effect of hypoleptinemia on the neuroendocrine responses to hypoglycemia. We utilized two separate experimental paradigms known to induce a hypoleptinemic state: 60% caloric restriction (CR) …

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Factors Associated With Being Overweight And Obesity In People Living With Human Immunodeficiency Virus On Antiretroviral Therapy: Socioclinical, Inflammation, And Metabolic Markers, Jeanne Goupil De Bouillé, Corinne Vigouroux, Lorraine Plessis, Mathilde Ghislain, Jean Paul Teglas, Faroudy Boufassa, Cécile Goujard, Dorothée Vignes, Olivier Bouchaud, Dominique Salmon, Laurence Meyer, Sophie Abgrall, O. B., O. B., F. B., F. B., Robert Carlier, Rosemary Dray-Spira, M. G., C. G., C. G., C. G., L. P., L. P., Lucie Marchand, L. M., Ventzislava Petrov-Sanchez, Christine Rouzioux, Rémonie Seng, Rémonie Seng, Rodolphe Thiebaut, Jean Paul Viard, Jean Paul Viard, S. A.

Division of Basic Science Faculty Publications

Background: We investigated the association between socioclinical, inflammatory, and metabolic markers and weight gain in people with human immunodeficiency virus (HIV) on combination antiretroviral therapy (cART). Methods: Individuals from the COPANA cohort of normal weight (body mass index [BMI], 18.5-24.9 [calculated as weight in kilograms divided by height in meters squared) at cART initiation who achieved virological suppression (viral load, < 50 copies/mL) and maintained it through 36 months of treatment were selected. Clinical, immunovirological, and socioeconomic data and inflammation (high-sensitivity C-reactive protein, CXCL10, CXCL8, interleukin 6, soluble tumor necrosis factor receptors 1 and 2, soluble CD14, and soluble CD16) and serum metabolic (glucose, insulin, lipid profile, adiponectin, and leptin) markers were assessed. Factors associated with becoming overweight (BMI, 25-29.9) or obese (BMI, ≥30) at 36 months were assessed using multivariate logistic regression models. Results: After 36 months of cART, 32 of 158 people with HIV (20%) became overweight or obese (21% female; 65% born in France and 23% born in sub-Saharan Africa; median BMI at cART initiation, 22 [interquartile range, 21-23]). After adjustment, higher BMI, originating from sub-Saharan Africa, living in a couple, and higher soluble tumor necrosis factor receptor 2 and lower adiponectin concentrations at cART initiation were associated with becoming overweight or obese. Conclusion: Weight gain on cART is multifactorial. Special attention should be given to migrants from sub-Saharan Africa. Monocyte activation and adipocyte dysfunction at cART initiation affect weight regulation.

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Grow Fast, Die Young: Does Compensatory Growth Reduce Survival Of Juvenile Blacktip Sharks (Carcharhinus Limbatus) In The Western Gulf Of Mexico?, Philip Matich, Jeffrey D. Plumlee, Mark Fisher

Faculty Publications

Effective conservation and management necessitate an understanding of the ecological mechanisms that shape species life histories in order to predict how variability in natural and anthropogenic impacts will alter growth rates, recruitment, and survival. Among these mechanisms, the interaction between parturition timing and prey availability frequently influences offspring success, particularly when postnatal care is absent. Here, we assess how parturition timing and nursery conditions, including prey abundance and environmental conditions, influence the growth and potential survival of blacktip sharks (Carcharhinus limbatus) in western Gulf of Mexico (GOM) estuaries over their first year. Catch data from long-term gillnet monitoring allowed for …

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Survival Of Western Gulf Coast Mottled Ducks (Anas Fulvigula) In The Path Of A Category 4 Hurricane, Kevin M. Ringelman, Elizabeth S. Bonczek, Joseph R. Marty, Ashley R. Booth, Alexandre L. Dopkin

Faculty Publications

Tropical cyclones are the most powerful storms on earth, causing catastrophic damage to human lives and infrastructure. Hurricanes also cause wildlife mortality when they make landfall, but the severity of these effects is difficult to quantify because data collection is either logistically impossible or deprioritized in the wake of human tragedy. On August 27, 2020, Hurricane Laura made landfall in southwestern Louisiana with maximum sustained winds of 241 kph (150 mph), making it one of the most powerful storms to strike the mainland United States. Hurricane Laura passed directly over the core breeding range of the western Gulf Coast population …

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Morphological Consequences Of Climate Change For Resident Birds In Intact Amazonian Rainforest, Vitek Jirinec, Ryan C. Burner, Bruna R. Amaral, Richard O. Bierregaard, Gilberto Fernández-Arellano, Angélica Hernández-Palma, Erik I. Johnson, Thomas E. Lovejoy, Luke L. Powell, Cameron L. Rutt, Jared D. Wolfe, Philip C. Stouffer

Faculty Publications

Warming from climate change is expected to reduce body size of endotherms, but studies from temperate systems have produced equivocal results. Over four decades, we collected morphometric data on a nonmigratory understory bird community within Amazonian primary rainforest that is experiencing increasingly extreme climate. All 77 species showed lower mean mass since the early 1980s-nearly half with 95% confidence. A third of species concomitantly increased wing length, driving a decrease in mass:wing ratio for 69% of species. Seasonal precipitation patterns were generally better than temperature at explaining morphological variation. Short-term climatic conditions affected all metrics, but time trends in wing …

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Erratum: Range-Wide Population Genetic Analysis Of Seaside Sparrows (Ammospiza Maritima) Supports At Least Five Distinct Population Segments That Do Not Align With Current Subspecies Descriptions (The Condor Doi: 10.1093/Ornithapp/Duab019), Kathryn E.C. Davis, Amie E. Settlecowski, Mackenzie R. Roeder, Carolyn Enloe, Thomas Virzi, Margaret E. Hunter, Stefan Woltmann, Sabrina S. Taylor

Faculty Publications

In the originally published version of this manuscript, the author Stefan Woltmann was erroneously given affiliation 3, Florida Fish and Wildlife Conservation Commission, Lovett E. Williams Jr. Wildlife Research Lab, Gainesville, Florida, USA. Dr. Woltmann s correct information is affiliation 2, Department of Biology and Center of Excellence for Field Biology, Austin Peay State University, Clarksville, Tennessee, USA, and this has been updated in the original article. The publisher regrets this error.

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Association Between The Fto Rs9939609 Single Nucleotide Polymorphism And Dietary Adherence During A 2-Year Caloric Restriction Intervention: Exploratory Analyses From Calerie™ Phase 2, James L. Dorling, Daniel W. Belsky, Susan B. Racette, Sai Krupa Das, Eric Ravussin, Leanne M. Redman, Christoph Höchsmann, Kim M. Huffman, William E. Kraus, Michael S. Kobor, Julia L. Macisaac, David T.S. Lin, David L. Corcoran, Corby K. Martin

Clinical Research Faculty Publications

Caloric restriction (CR) improves markers of aging in humans; but it is not known if the fat mass and obesity-associated gene (FTO) rs9939609 single nucleotide polymorphism (SNP), which is associated with appetite and energy intake, influences adherence to prolonged CR. Utilizing data from the two-year Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE™) phase 2 randomized controlled trial, we tested whether the FTO rs9939609 SNP was associated with adherence to CR in healthy adults without obesity. As secondary aims, we assessed whether the FTO rs9939609 SNP was associated with changes in body composition, biomarkers of aging, and …

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Mlr-1023 Treatment In Mice And Humans Induces A Thermogenic Program, And Menthol Potentiates The Effect, Candida J. Rebello, Ann A. Coulter, Andrew G. Reaume, Weina Cong, Luke A. Cusimano, Frank L. Greenway

Clinical Research Faculty Publications

A glucose-lowering medication that acts by a different mechanism than metformin, or other approved diabetes medications, can supplement monotherapies when patients fail to meet blood glucose goals. We examined the actions underlying the effects of an insulin sensitizer, tolimidone (MLR-1023) and investigated its effects on body weight. Diet-induced obesity (CD1/ICR) and type 2 diabetes (db/db) mouse models were used to study the effect of MLR-1023 on metabolic outcomes and to explore its synergy with menthol. We also examined the efficacy of MLR-1023 alone in a clinical trial (NCT02317796), as well as in combination with menthol in human adipocytes. MLR-1023 produced …

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The Breath Print Represents A Novel Biomarker Of Malnutrition In Pulmonary Arterial Hypertension: A Proof Of Concept Study, Jacob T. Mey, Mary C. Rath, Kathleen Mclaughlin, Marianne Galang, Kathryn Lynch, Jaime Dimattio, Hillary Nason, Shengping Yang, Celia A. Melillo, David E. Grove, Adriano R. Tonelli, Gustavo A. Heresi, John P. Kirwan, Raed A. Dweik

Division of Basic Science Faculty Publications

Background: The breath print is a quantitative measurement of molecules in exhaled breath and represents a new frontier for biomarker identification. It is unknown whether this state-of-the-art, noninvasive method can detect malnutrition. We hypothesize that individuals with malnutrition will present with a distinguishable breath print. Methods: We conducted a retrospective chart review on patients with previously analyzed breath samples to identify malnutrition. Breath was analyzed by selected-ion flow-tube mass spectrometry. Registered dietitians conducted a retrospective chart review to collect malnutrition diagnoses and nutrition status indicators. Patients were categorized into one of four groups: pulmonary arterial hypertension (PAH), PAH with malnutrition …

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A Whole-Grain Diet Increases Whole-Body Protein Balance Compared With A Macronutrient-Matched Refined-Grain Diet, Jacob T. Mey, Jean Philippe Godin, Amanda R. Scelsi, Emily L. Kullman, Steven K. Malin, Shengping Yang, Z. Elizabeth Floyd, Alexander Poulev, Roger A. Fielding, Alastair B. Ross, John P. Kirwan

Division of Basic Science Faculty Publications

Background: There are limited data from randomized control trials to support or refute the contention that whole-grains can enhance protein metabolism in humans. Objectives: To examine: 1) the clinical effects of a whole-grain diet on whole-body protein turnover; 2) the cellular effects of whole-grains on protein synthesis in skeletal muscle cells; and 3) the population effects of whole-grain intake on age-related muscle loss. Methods: Adults with overweight/obesity (n = 14; age = 40 ± 7 y; BMI = 33 ± 5 kg/m2) were recruited into a crossover, randomized controlled trial (NCT01411540) in which isocaloric, macronutrient-matched whole-grain and refined-grain diets were …

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Bioactive Compounds From Artemisia Dracunculus L. Activate Ampk Signaling In Skeletal Muscle, B. Vandanmagsar, Y. Yu, C. Simmler, T. N. Dang, P. Kuhn, A. Poulev, D. M. Ribnicky, G. F. Pauli, Z. E. Floyd

Division of Basic Science Faculty Publications

An extract from Artemisia dracunculus L. (termed PMI-5011) improves glucose homeostasis by enhancing insulin action and reducing ectopic lipid accumulation, while increasing fat oxidation in skeletal muscle tissue in obese insulin resistant male mice. A chalcone, DMC-2, in PMI-5011 is the major bioactive that enhances insulin signaling and activation of AKT. However, the mechanism by which PMI-5011 improves lipid metabolism is unknown. AMPK is the cellular energy and metabolic sensor and a key regulator of lipid metabolism in muscle. This study examined PMI-5011 activation of AMPK signaling using murine C2C12 muscle cell culture and skeletal muscle tissue. Findings show that …

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Exploring Text Mining For Recent Consumer And Sensory Studies About Alternative Proteins, Ziyang Chen, Cristhiam Gurdian, Chetan Sharma, Witoon Prinyawiwatkul, Damir D. Torrico

Faculty Publications

Increased meat consumption has been associated with the overuse of fresh water, under-ground water contamination, land degradation, and negative animal welfare. To mitigate these problems, replacing animal meat products with alternatives such as plant-, insect-, algae-, or yeast-fermented-based proteins, and/or cultured meat, is a viable strategy. Nowadays, there is a vast amount of information regarding consumers’ perceptions of alternative proteins in scientific outlets. Sorting and arranging this information can be time-consuming. To overcome this drawback, text mining and Natural Language Processing (NLP) are introduced as novel approaches to obtain sensory data and rapidly identify current consumer trends. In this study, …

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Examining The Size-Specific Photosynthesis-Irradiance Parameters And Relationship With Phytoplankton Types In A Subtropical Marginal Sea, Haoran Liu, Yuyuan Xie, Yong Qiu, Lei Wang, Feipeng Wang, Edward A. Laws, Bangqin Huang

Faculty Publications

Through photosynthesis, phytoplankton initiate material cycling and the flow of energy through marine ecosystems. The structure of marine ecosystems is sensitive to the size of primary producers, and size-specific photosynthesis-irradiance (P-I) parameters are required for modeling the size-specific primary production. We defined a phytoplankton type to be a group of phytoplankton communities with similar compositions and hypothesized that a function of phytoplankton types might be used to quantify systematic differences of P-I parameters between size classes (structural effects) and variations of the magnitudes of those parameters if the overlap between habitats was small (environmental effects). To test this hypothesis, we …

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Interactions 2021, Thomas J. Long School Of Pharmacy

Interactions

In each issue of Interactions, the School’s annual magazine you will find stories about students, faculty and alumni from each of our disciplines. Learn about the ways our students, faculty and alumni are impacting their communities through health care outreach. Read about their research and how they are contributing to advances in patient care. Meet our Alumni of the Year and get to know our faculty.

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Calvin Theological Journal (Vol 56 No 2 - November 2021), Calvin Theological Seminary

Calvin Theological Journal

From the Editor: Karin Maag - 229 / Articles: Wholehearted Commitment to Sound Pastoral Theology and Care: What Martin Bucer and John Calvin Can Teach Today’s Pastors by Stéphan van der Watt - 231 / A Variety of Voices: Reformed Theologians on the Theory of Evolution by Gijsbert van den Brink and Harry Cook - 265 / Short Studies: The English-language Reception of K. H. Miskotte by Collin Cornell - 293 / The Scandal of Sheer Grace: When Mercy Offends by James K. A. Smith - 309 / Preaching Christ from the Old Testament: A Look Back after Thirty Years …

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Expanding The Frame: Using Masculinities Analyses To Challenge Gender And Race Hierarchy, Nancy Dowd

UF Law Faculty Publications

Kimberly Bailey’s fascinating article, Male Same-Sex “Horseplay”: The Epicenter of Sexual Harassment? seeks to expose and to further analyze harassment of women by paying attention to the patterns and meaning of male-male harassment between straight men. By the sophisticated use of masculinities theory and research, she seeks to expand not only the boundaries of male-male harassment but also the linkages between male-male and male-female harassment. Sexual
harassment doctrine as constructed thus far excludes certain conduct as not discriminatory. As Professor Bailey notes, in Oncale v. Sundowner Offshore Services, Inc., the Court stated that it was not creating a “general civility …

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Computational Simulation Of The Lung Doses Of Air-Borne Fine And Ultrafine Particles Inhaled By Humans At Industrial Workplaces, Mohammed Ali

Technology Faculty Publications and Presentations

This study correlates computational predictions with in-vivo experimental results of inhaled fine and ultrafine particulate matters (PMs) transport, dissemination, and deposition in the human respiratory airways. Epidemiological studies suggest that workplace exposure of anthropogenic pollutant PMs as a risk factor for increased susceptibility to acute broncho-pulmonary infections. However, investigations on detailed human inhalation and PM transport processes are restrictive from time, cost, and ethical perspectives. To overcome this problem, computational simulation of particle deposition based on the Multiple Path Particle Dosimetry (MPPD) model was employed. Here, the physical, mechanical, and electrical properties of PMs of carbon black and nanoparticles from …

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Prediction Of Heterosis In The Recent Rapeseed (Brassica Napus) Polyploid By Pairing Parental Nucleotide Sequences, Qian Wang, Tao Yan, Zhengbiao Long, Luna Yue Huang, Yang Zhu, Ying Xu, Xiaoyang Chen, Haksong Pak, Jiqiang Li, Dezhi Wu, Yang Xu, Shuijin Hua, Lixi Jiang

Publications

The utilization of heterosis is a successful strategy in increasing yield for many crops. However, it consumes tremendous manpower to test the combining ability of the parents in fields. Here, we applied the genomic-selection (GS) strategy and developed models that significantly increase the predictability of heterosis by introducing the concept of a regional parental genetic-similarity index (PGSI) and reducing dimension in the calculation matrix in a machine-learning approach. Overall, PGSI negatively affected grain yield and several other traits but positively influenced the thousand-seed weight of the hybrids. It was found that the C subgenome of rapeseed had a greater impact …

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Ultracompact Fluorescence Smartphone Attachment Using Built-In Optics For Protoporphyrin-Ix Quantification In Skin, Brady Hunt, Samuel S. Streeter, Alberto J. Ruiz, M. Shane Chapman, Brian W. Pogue

Dartmouth Scholarship

Smartphone-based fluorescence imaging systems have the potential to provide convenient quantitative image guidance at the point of care. However, common approaches have required the addition of complex optical attachments, which reduce translation potential. In this study, a simple clip-on attachment appropriate for fluorescence imaging of protoporphyrin-IX (PpIX) in skin was designed using the built-in light source and ultrawide camera sensor of a smartphone. Software control for image acquisition and quantitative analysis was developed using the 10-bit video capability of the phone. Optical performance was characterized using PpIX in liquid tissue phantoms and endogenously produced PpIX in mice and human skin. …

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2020-2021 Faculty Senate Xxvi - November 1, 2021 Minutes Summary, Faculty Senate

Faculty Senate Agendas & Minutes

No abstract provided.

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Numerical Study Of Graphene/Au/Sic Waveguide-Based Surface Plasmon Resonance Sensor, Wei Du, Lucas Miller, Feng Zhao

Electrical and Computer Engineering Faculty Research & Creative Works

A new waveguide-based surface plasmon resonance (SPR) sensor was proposed and investigated by numerical simulation. The sensor consists of a graphene cover layer, a gold (Au) thin film, and a silicon carbide (SiC) waveguide layer on a silicon dioxide/silicon (SiO₂ /Si) substrate. The large bandgap energy of SiC allows the sensor to operate in the visible and near-infrared wavelength ranges, which effectively reduces the light absorption in water to improve the sensitivity. The sensor was characterized by comparing the shift of the resonance wavelength peak with change of the refractive index (RI), which mimics the change of analyte concentration …

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Propagation Of A De Novo Gene Under Natural Selection: Antifreeze Glycoprotein Genes And Their Evolutionary History In Codfishes, Xuan Zhuang, C.-H. Christina Cheng

Biological Sciences Faculty Publications and Presentations

The de novo birth of functional genes from non-coding DNA as an important contributor to new gene formation is increasingly supported by evidence from diverse eukaryotic lineages. However, many uncertainties remain, including how the incipient de novo genes would continue to evolve and the molecular mechanisms underlying their evolutionary trajectory. Here we address these questions by investigating evolutionary history of the de novo antifreeze glycoprotein (AFGP) gene and gene family in gadid (codfish) lineages. We examined AFGP phenotype on a phylogenetic framework encompassing a broad sampling of gadids from freezing and non-freezing habitats. In three select species representing different AFGP-bearing …

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Neural Impact Of Neighborhood Socioeconomic Disadvantage In Traumatically Injured Adults, E. Kate Webb, Carissa N. Weis, Ashley A. Huggins, Jacklynn M. Fitzgerald, Kenneth P. Bennett, Claire Maria Bird, Elizabeth A. Parisi, Maddy Kallenbach, Tara A. Miskovich, Terri A Deroon-Cassini, Christine L. Larson

Psychology Faculty Research and Publications

Nearly 14 percent of Americans live in a socioeconomically disadvantaged neighborhood. Lower individual socioeconomic position (iSEP) has been linked to increased exposure to trauma and stress, as well as to alterations in brain structure and function; however, the neural effects of neighborhood SEP (nSEP) factors, such as neighborhood disadvantage, are unclear. Using a multi-modal approach with participants who recently experienced a traumatic injury (N = 185), we investigated the impact of neighborhood disadvantage, acute post-traumatic stress symptoms, and iSEP on brain structure and functional connectivity at rest. After controlling for iSEP, demographic variables, and acute PTSD symptoms, nSEP was …

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Full-Text Articles in Entire DC Network

Juul 3% Menthol Aerosol Extracts Exhibit Toxicity And Alter Gene Expression Of Murine Macrophages, Samantha Jindia

Honors Capstones

Analysis Of Young, Lineage Specific Alu Elements In Cebus, Catherine Rockwell

Honors Capstones

Murine Trophoblast Stem Cells And Their Differentiated Cells Attenuate Zika Virus In Vitro By Reducing Glycosylation Of The Viral Envelope Protein, Biswas Neupane, Mona Fendereski, Farzana Nazneen, Yanlin Guo, Fengwei Bai

Faculty Publications

Faculty Publications

Faculty Publications

Development Of An Open Hardware 3-D Printed Conveyor Device For Continuous Cryopreservation Of Non-Batched Samples, Yue Liu, Melissa Eskridge, Amy Guitreau, Jacob Beckham, Megan Chesnut, Leticia Torres, Terrence R. Tiersch, William Todd Monroe

Faculty Publications

Rickettsia Conorii Survival In Thp-1 Macrophages Involves Host Lipid Droplet Alterations And Active Rickettsial Protein Production, Paige E. Allen, Robert C. Noland, Juan J. Martinez

Division of Basic Science Faculty Publications

Division of Basic Science Faculty Publications

Division of Basic Science Faculty Publications

Grow Fast, Die Young: Does Compensatory Growth Reduce Survival Of Juvenile Blacktip Sharks (Carcharhinus Limbatus) In The Western Gulf Of Mexico?, Philip Matich, Jeffrey D. Plumlee, Mark Fisher

Faculty Publications

Survival Of Western Gulf Coast Mottled Ducks (Anas Fulvigula) In The Path Of A Category 4 Hurricane, Kevin M. Ringelman, Elizabeth S. Bonczek, Joseph R. Marty, Ashley R. Booth, Alexandre L. Dopkin

Faculty Publications

Faculty Publications

Faculty Publications

Clinical Research Faculty Publications

Mlr-1023 Treatment In Mice And Humans Induces A Thermogenic Program, And Menthol Potentiates The Effect, Candida J. Rebello, Ann A. Coulter, Andrew G. Reaume, Weina Cong, Luke A. Cusimano, Frank L. Greenway

Clinical Research Faculty Publications

Division of Basic Science Faculty Publications

Division of Basic Science Faculty Publications

Bioactive Compounds From Artemisia Dracunculus L. Activate Ampk Signaling In Skeletal Muscle, B. Vandanmagsar, Y. Yu, C. Simmler, T. N. Dang, P. Kuhn, A. Poulev, D. M. Ribnicky, G. F. Pauli, Z. E. Floyd

Division of Basic Science Faculty Publications

Exploring Text Mining For Recent Consumer And Sensory Studies About Alternative Proteins, Ziyang Chen, Cristhiam Gurdian, Chetan Sharma, Witoon Prinyawiwatkul, Damir D. Torrico

Faculty Publications

Examining The Size-Specific Photosynthesis-Irradiance Parameters And Relationship With Phytoplankton Types In A Subtropical Marginal Sea, Haoran Liu, Yuyuan Xie, Yong Qiu, Lei Wang, Feipeng Wang, Edward A. Laws, Bangqin Huang

Faculty Publications

Interactions 2021, Thomas J. Long School Of Pharmacy

Interactions

Calvin Theological Journal (Vol 56 No 2 - November 2021), Calvin Theological Seminary

Calvin Theological Journal

Expanding The Frame: Using Masculinities Analyses To Challenge Gender And Race Hierarchy, Nancy Dowd

UF Law Faculty Publications

Computational Simulation Of The Lung Doses Of Air-Borne Fine And Ultrafine Particles Inhaled By Humans At Industrial Workplaces, Mohammed Ali

Technology Faculty Publications and Presentations

Prediction Of Heterosis In The Recent Rapeseed (Brassica Napus) Polyploid By Pairing Parental Nucleotide Sequences, Qian Wang, Tao Yan, Zhengbiao Long, Luna Yue Huang, Yang Zhu, Ying Xu, Xiaoyang Chen, Haksong Pak, Jiqiang Li, Dezhi Wu, Yang Xu, Shuijin Hua, Lixi Jiang

Publications

Ultracompact Fluorescence Smartphone Attachment Using Built-In Optics For Protoporphyrin-Ix Quantification In Skin, Brady Hunt, Samuel S. Streeter, Alberto J. Ruiz, M. Shane Chapman, Brian W. Pogue

Dartmouth Scholarship

2020-2021 Faculty Senate Xxvi - November 1, 2021 Minutes Summary, Faculty Senate

Faculty Senate Agendas & Minutes

Numerical Study Of Graphene/Au/Sic Waveguide-Based Surface Plasmon Resonance Sensor, Wei Du, Lucas Miller, Feng Zhao

Electrical and Computer Engineering Faculty Research & Creative Works

Propagation Of A De Novo Gene Under Natural Selection: Antifreeze Glycoprotein Genes And Their Evolutionary History In Codfishes, Xuan Zhuang, C.-H. Christina Cheng

Biological Sciences Faculty Publications and Presentations

Psychology Faculty Research and Publications