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Menstruation Discrimination And The Problem Of Shadow Precedents, Deborah Widiss

Articles by Maurer Faculty

A burgeoning menstrual justice movement calls attention to menstruation-related discrimination in workplaces, schools, prisons, and many other aspects of life. In recent years, a few courts have suggested such discrimination could violate Title VII, the federal law that prohibits sex discrimination in employment. Their analysis focuses on the Pregnancy Discrimination Act (PDA), an amendment to Title VII passed to override a Supreme Court case that had held pregnancy discrimination was not sex discrimination.

This essay, written for a symposium at Columbia Law School, applies my earlier research on the statutory interpretation of Congressional overrides to highlight two potential challenges this …

University Research On Winter Growing Of Container-Grown Strawberries Translates To Grower's Farm Trial, Stacy A. Adams, Ellen T. Paparozzi, Ryan Pekarek, Dave P. Lambe, George Meyer, M. Elizabeth Conley, Paul Read

Department of Agronomy and Horticulture: Faculty Publications

Strawberries are only seasonally available in Nebraska (NE). If an affordable heated structure can be designed, then opportunity exists to increase on-farm income by producing strawberries off-season during high-value market periods. A series of university greenhouse trials were conducted from 2010 to 2012. The varieties Evie-2 and Seascape were identified as being most productive under a low technology growing scheme. A new research project, which ran from fall to late spring (2013–2014), was designed to determine if this production scheme would translate to a commercial grower. Varieties Seascape and Evie-2 (each at two grades indicated by +) and San Andreas …

Lindja E Indukuar Dhe Përfundimi Peripartal, Arlinda Uka

Theses and Dissertations

Lindja e indukuar është proces i stimulimit artificial të mitrës për të filluar lindjen. Stimulimi i lindjes nënkupton stimulimin e mitrës gjatë lindjes për të rritur frekuencën dhe forcën e kontraktimeve. Induksioni dhe stimulimi i lindjes ende janë sfidë për obstetrit, mamitë dhe infermieret në botë edhe te ne, sepse bartin një sërë rreziqesh si për shëndetin e nënës ashtu edhe për frytin - të porsalindurin. Andaj, qëllimi i punimit tonë është që të hulumtohen rastet e lindjeve të indukuara dhe të stimuluara në Klinikën Obstetrike - Gjinekologjike ne QKUK, në periudhën Janar-Mars, 2020.

Studimi është i llojit retrospektiv, i …

New Look Of Ebv Lmp1 Signaling Landscape, Ling Wang, Shunbin Ning

ETSU Faculty Works

The Epstein–Barr Virus (EBV) principal oncoprotein Latent Membrane Protein 1 (LMP1) is a member of the Tumor Necrosis Factor Receptor (TNFR) superfamily with constitutive activity. LMP1 shares many features with Pathogen Recognition Receptors (PRRs), including the use of TRAFs, adaptors, and kinase cascades, for signal transduction leading to the activation of NFκB, AP1, and Akt, as well as a subset of IRFs and likely the master antioxidative transcription factor NRF2, which we have gradually added to the list. In recent years, we have discovered the Linear UBiquitin Assembly Complex (LUBAC), the adaptor protein LIMD1, and the ubiquitin sensor and signaling …

As Brown Has Waned, Aziz Z. Huq

University of Chicago Law Review

No abstract provided.

2021-2022 Spring Bulletin, University Of Mississippi Medical Center

Bulletins/Catalogs

2021-2022 Spring Bulletin

Long-Term Effects Of In Utero Exposure To “The Year Without A Summer”, Hamid Noghanibehambari, Farzaneh Noghani, Nahid Tavassoli, Mostafa Toranji

Economic and Business Review

This paper uses the aftermath of the great Tambora eruption in 1815 as a natural experiment to explore the long-term effects of a nutritional shock during prenatal development. The volcanic explosion of Tambora formed substantial ash columns which hampered sunlight, cooled down the surface temperature, reduced the length of the growing season, and led to a severe harvest failure during summer and winter of 1816 in Europe and northeastern states of America. US decennial census 1850 provides evidence that cohorts in utero during the climate anomaly revealed lower literacy rates, lower labor force participation rates, a fewer number of own …

Characterization Of Commercially Available Conductive Filament And Their Application In Sensors And Actuators, Fraser J. Daniel

Doctoral Dissertations

The primary aim of this study is to contribute to the field of additives that would enable the fabrication of electrical sensors and actuators completely via Material Extrusion based Additive Manufacturing (MEAM). The second aim of the study is to provide the necessary characterization to facilitate the development of applications that predicts electrical part performance. The electrical characterization of two conductive poly-lactic acid (PLA) filaments, namely, c-PLA with carbon black and graphene PLA was performed to study the temperature coefficient of the resistance. Resistivity of carbon black filament was compared to a printed single layer and with that of a …

Prevention Of Organ-Specific Doxorubicin Induced Toxicity Using Physiologically-Based Pharmacokinetic Modeling And Therapeutic Drug Monitoring, Hillary Husband

Doctoral Dissertations

Physiology-based pharmacokinetic models are mathematical models that characterize the behavior of a drug and have compartmental equations that are representative of specific tissues and physiological processes.[1, 2] Doxorubicin is an anthracycline antibiotic that is effective and widely used in anticancer therapy due to its potent cytotoxicity. Unfortunately, with that potency comes cardiotoxic side effects related to cumulative lifetime dose.[3] Specifically, the toxicity is related to the accumulation of the primary metabolite doxorubicinol (DOXol) in the heart.[4] Since the toxicity is organ-specific, the best way to characterize the behavior is through PBPK modeling.[2] Since PBPK models tend to be large systems …

Crossing The Blood-Brain Barrier Using Peptide Vectors For The Treatment Of Traumatic Brain Injury, Jolin P. Rodrigues

Doctoral Dissertations

Here, the BBB-crossing ability of a Trojan horse peptide conjugated to a short therapeutic peptide was evaluated, with the aim to halt the progression of TBI-associated neuronal damage in a mouse experimental model of TBI. An associated study was also conducted to develop a new biosensor to probe hydrogen peroxide – a biomarker of chronic inflammation in the brain. The long-term goal of this study was to assess the regenerative or neuroprotective effect of this potential therapeutic peptide on neural disease pathology, thus expanding the known library of BBB-crossing peptides, and developing new tools for the study of inflammation, such …

The Ionic Selectivity Of Lysenin Channels In Open And Sub-Conducting States, Andrew Bogard, Pangaea W. Finn, Fulton Mckinney, Ilinca M. Flacau, Aviana R. Smith, Rosey Whiting, Daniel Fologea

Physics Faculty Publications and Presentations

The electrochemical gradients established across cell membranes are paramount for the execution of biological functions. Besides ion channels, other transporters, such as exogenous pore-forming toxins, may present ionic selectivity upon reconstitution in natural and artificial lipid membranes and contribute to the electrochemical gradients. In this context, we utilized electrophysiology approaches to assess the ionic selectivity of the pore-forming toxin lysenin reconstituted in planar bilayer lipid membranes. The membrane voltages were determined from the reversal potentials recorded upon channel exposure to asymmetrical ionic conditions, and the permeability ratios were calculated from the fit with the Goldman–Hodgkin–Katz equation. Our work shows that …

Automated Detection Of Marine Glacier Calving Fronts Using The 2-D Wavelet Transform Modulus Maxima Segmentation Method, Julia Liu, Ellyn M. Enderlin, Hans-Peter Marshall, Andre Khalil

Geosciences Faculty Publications and Presentations

Changes in the calving front position of marine-terminating glaciers strongly influence the mass balance of glaciers, ice caps, and ice sheets. At present, quantification of frontal position change primarily relies on time-consuming and subjective manual mapping techniques, limiting our ability to understand changes to glacier calving fronts. Here we describe a newly developed automated method of mapping glacier calving fronts in satellite imagery using observations from a representative sample of Greenland’s peripheral marine-terminating glaciers. Our method is adapted from the 2-D wavelet transform modulus maxima (WTMM) segmentation method, which has been used previously for image segmentation in biomedical and other …

Vhs Archives, Committed Media Praxis, And ‘Queer Cinema', Alexandra Juhasz

Publications and Research

Committed media praxis is a doing as much as it is a knowing. Queerness is a manner of being as much as it is a politics, theory, or set of modish objects. This chapter about topics that are also processes—queer, media praxis, cinema—performs these across two acts: “Part 1: A Hesitant or Maybe Just Slightly Defiant Preamble,” is a creative unfolding, in the body of the text and as much so in its footnotes, of the author’s “queer feminist media praxis”: “Part 2: VHS Archives” is a demonstration of VHS Archives, a multi-sited, many-yeared project in experimental pedagogy, web-based archival …

Anal Human Papillomavirus Infection Among Men Who Have Sex With Men And Transgender Women Living With And Without Hiv In Pakistan: Findings From A Cross-Sectional Study, Muslima Ejaz, Soren Andersson, Salma Batool, Tazeen Saeed Ali, Anna Mia Ekström

Community Health Sciences

Objectives: The aim of this study was to determine the prevalence of infection, genotypes and risk factors for human papillomavirus (HPV) among men who have sex with men (MSM) and transgender women living with and without HIV in Pakistan. Anal infection with HPV is very common worldwide among MSM, particularly among MSM living with HIV. The high prevalence of HIV among MSM and male-to-female transgendered individuals in Pakistan is a significant health concern since access to screening and health-seeking is often delayed in this stigmatised key population.
Design: This cross-sectional study was conducted between March 2016 and November 2017.
Participants, …

Extracellular Matrix-Mimetic Hydrogels For Treating Neural Tissue Injury: A Focus On Fibrin, Hyaluronic Acid, And Elastin-Like Polypeptide Hydrogels, Derek W. Nelson, Ryan J. Gilbert

Chemical and Biochemical Engineering Faculty Research & Creative Works

Neurological and functional recovery is limited following central nervous system injury and severe injury to the peripheral nervous system. Extracellular matrix (ECM)-mimetic hydrogels are of particular interest as regenerative scaffolds for the injured nervous system as they provide 3D bioactive interfaces that modulate cellular response to the injury environment and provide naturally degradable scaffolding for effective tissue remodeling. In this review, three unique ECM-mimetic hydrogels used in models of neural injury are reviewed: fibrin hydrogels, which rely on a naturally occurring enzymatic gelation, hyaluronic acid hydrogels, which require chemical modification prior to chemical crosslinking, and elastin-like polypeptide (ELP) hydrogels, which …

A Prospective Examination Of Sex Differences In Posttraumatic Autonomic Functioning, Antonia V. Seligowski, Elizabeth R. Steuber, Rebecca Hinrichs, Mariam H. Reda, Charis N. Wiltshire, Cassandra P. Wanna, Sterling J. Winters, Karlye A. Phillips, Stacey L. House, Francesca L. Beaudoin, Xinming An, Jennifer S. Stevens, Donglin Zeng, Thomas C. Neylan, Gari D. Clifford, Sarah D. Linnstaedt, Laura T. Germine, Kenneth A. Bollen, Guia Guffanti, Scott L. Rauch, John P. Haran, Alan B. Storrow, Christopher A. Lewandowski, Paul I. Musey, Phyllis L. Hendry, Sophia Sheikh, Christopher W. Jones, Brittany E. Punches, Michael C. Kurz, Vishnu P. Murty, Meghan E. Mcgrath, Lauren A. Hudak, Jose L. Pascual, Mark J. Seamon, Elizabeth M. Datner, Anna M. Chang, Claire Pearson, David A. Peak, Roland C. Merchant, Robert M. Domeier, Niels K. Rathlev, Brian J. O'Neil, Leon D. Sanchez, Steven E. Bruce, Mark W. Miller, Robert H. Pietrzak, Jutta Joormann, Deanna M. Barch, Diego A. Pizzagalli, John F. Sheridan, Beatriz Luna, Steven E. Harte, James M. Elliott, Karestan C. Koenen, Ronald C. Kessler, Samuel A. Mclean, Kerry J. Ressler, Tanja Jovanovic

Emergency Medicine Articles

BACKGROUND: Cross-sectional studies have found that individuals with posttraumatic stress disorder (PTSD) exhibit deficits in autonomic functioning. While PTSD rates are twice as high in women compared to men, sex differences in autonomic functioning are relatively unknown among trauma-exposed populations. The current study used a prospective design to examine sex differences in posttraumatic autonomic functioning.

METHODS: 192 participants were recruited from emergency departments following trauma exposure (Mean age = 35.88, 68.2% female). Skin conductance was measured in the emergency department; fear conditioning was completed two weeks later and included measures of blood pressure (BP), heart rate (HR), and high frequency …

Spatiotemporal Variations In Liquid Water Content In A Seasonal Snowpack: Implications For Radar Remote Sensing, Randall Bonnell, Daniel Mcgrath, Keith Williams, Ryan Webb, Steven R. Fassnacht, Hans-Peter Marshall

Geosciences Faculty Publications and Presentations

Radar instruments have been widely used to measure snow water equivalent (SWE) and Interferometric Synthetic Aperture Radar is a promising approach for doing so from spaceborne platforms. Electromagnetic waves propagate through the snowpack at a velocity determined by its dielectric permittivity. Velocity estimates are a significant source of uncertainty in radar SWE retrievals, especially in wet snow. In dry snow, velocity can be calculated from relations between permittivity and snow density. However, wet snow velocity is a function of both snow density and liquid water content (LWC); the latter exhibits high spatiotemporal variability, there is no standard observation method, and …

Coresets For Time Series Clustering, Lingxiao Huang, K. Sudhir, Nisheeth Vishnoi

Cowles Foundation Discussion Papers

We study the problem of constructing coresets for clustering problems with time series data. This problem has gained importance across many fields including biology, medicine, and economics due to the proliferation of sensors for real-time measurement and rapid drop in storage costs. In particular, we consider the setting where the time series data on N entities is generated from a Gaussian mixture model with autocorrelations over k clusters in R^d. Our main contribution is an algorithm to construct coresets for the maximum likelihood objective for this mixture model. Our algorithm is efficient, and, under a mild assumption on …

On The Relationship Between Pain Variability And Relief In Randomized Clinical Trials, Siddharth Tiwari '22

Student Publications & Research

Previous research suggests greater baseline variability is associated with greater pain relief in those who receive a placebo. However, studies that evidence this association do not control for confounding effects (natural history and regression-to-the-mean); for this reason, we analyzed data from two randomized clinical trials (Placebo I and Placebo II, N = 134) while adjusting for confounding effects via a no-treatment group. Results agree between the two placebo groups: both placebo groups showed a negligible correlation between baseline variability and adjusted response (r sp (CI 95% ) = 0.13 (−0.09, 0.37) and 0.01 (−0.15, 0.20) for Placebo I and II, …

The Enigma Of Clinical Next Generation Sequencing (Ngs) Based Genetic Testing Variant Annotation Tools: A Performance Evaluation Study, Sachleen Tuteja '23

Student Publications & Research

As the scientific community continues to discover novel genetic variants associated with human constitutional disorders, there is a growing need for a standardized approach for reporting of genetic variants, as accurate variant identification is crucial for effective diagnosis and treatment. Robust identification and annotation of genetic variants relevant for human germline disorders is foundational for clinical Next Generation Sequencing (NGS) assays. Using a manually curated set of 296 variants, generated by targeted gene panel sequencing using the ~4700 gene medical exome panel on 105 patients, we evaluated the performance of two variant annotation tools (Variant Effect Predictor and Alamut Batch) …

Protein Appetite At The Interface Between Nutrient Sensing And Physiological Homeostasis, Md Shahjalal Khan, Redin A. Spann, Heike Münzberg, Sangho Yu, Vance L. Albaugh, Yanlin He, Hans Rudolf Berthoud, Christopher D. Morrison

Division of Basic Science Faculty Publications

Feeding behavior is guided by multiple competing physiological needs, as animals must sense their internal nutritional state and then identify and consume foods that meet nutritional needs. Dietary protein intake is necessary to provide essential amino acids and represents a specific, distinct nutritional need. Consistent with this importance, there is a relatively strong body of literature indicating that protein intake is defended, such that animals sense the restriction of protein and adaptively alter feeding behavior to increase protein intake. Here, we argue that this matching of food consumption with physiological need requires at least two concurrent mechanisms: the first being …

Tau-Atrophy Variability Reveals Phenotypic Heterogeneity In Alzheimer's Disease, Sandhitsu R. Das, Xueying Lyu, Michael Tran Duong, Long Xie, Lauren Mccollum, Robin De Flores, Michael Dicalogero, David J. Irwin, Bradford C. Dickerson, Ilya M. Nasrallah, Paul A. Yushkevich, David A. Wolk, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Danielle Harvey

Clinical Research Faculty Publications

Objective: Tau neurofibrillary tangles (T) are the primary driver of downstream neurodegeneration (N) and subsequent cognitive impairment in Alzheimer's disease (AD). However, there is substantial variability in the T-N relationship – manifested in higher or lower atrophy than expected for level of tau in a given brain region. The goal of this study was to determine if region-based quantitation of this variability allows for identification of underlying modulatory factors, including polypathology. Methods: Cortical thickness (N) and 18F-Flortaucipir SUVR (T) were computed in 104 gray matter regions from a cohort of cognitively-impaired, amyloid-positive (A+) individuals. Region-specific residuals from a robust linear …

A Shift To Human Body Temperature (37°C) Rapidly Reprograms Multiple Adaptive Responses In Escherichia Coli That Would Facilitate Niche Survival And Colonization, Anastasia Gant Kanegusuku, Isidora N. Stankovic, Pamela A. Cote-Hammarlof, Priscilla H. Yong, Christine A. White-Ziegler

Biological Sciences: Faculty Publications

One of the first environmental cues sensed by a microbe as it enters a human host is an upshift in temperature to 37°C. In this dynamic time point analysis, we demonstrate that this environmental transition rapidly signals a multitude of gene expression changes in Escherichia coli. Bacteria grown at 23°C under aerobic conditions were shifted to 37°C, and mRNA expression was measured at time points after the shift to 37°C (t = 0.5, 1, and 4 h). The first hour is characterized by a transient shift to anaerobic respiration strategies and stress responses, particularly acid resistance, indicating that temperature serves …

A Reference Genome For The Nectar-Robbing Black-Throated Flowerpiercer (Diglossa Brunneiventris), A E. Hiller, R T. Brumfield, B C. Faircloth

Faculty Publications

Black-throated Flowerpiercers (Diglossa brunneiventris) are one species representing a phenotypically specialized group of tanagers (Thraupidae) that have hooked bills which allow them to feed by stealing nectar from the base of flowers. Members of the genus are widely distributed in montane regions from Mexico to northern Argentina, and previous studies of Diglossa have focused on their systematics, phylogenetics, and interesting natural history. Despite numerous studies of species within the genus, no genome assembly exists to represent these nectivorous tanagers. We described the assembly of a genome sequence representing a museum-vouchered, wild, female D. brunneiventris collected in Peru. By combining Pacific …

Genetic Responses And Aflatoxin Inhibition During Co-Culture Of Aflatoxigenic And Non-Aflatoxigenic Aspergillus Flavus, Rebecca R. Sweany, Brian M. Mack, Geromy G. Moore, Matthew K. Gilbert, Jeffrey W. Cary, Matthew D. Lebar, Kanniah Rajasekaran, Kenneth E. Damann

Faculty Publications

Aflatoxin is a carcinogenic mycotoxin produced by Aspergillus flavus. Non-aflatoxigenic (Non-tox) A. flavus isolates are deployed in corn fields as biocontrol because they substantially reduce aflatoxin contamination via direct replacement and additionally via direct contact or touch with toxigenic (Tox) isolates and secretion of inhibitory/degradative chemicals. To understand touch inhibition, HPLC analysis and RNA sequencing examined aflatoxin production and gene expression of Non-tox isolate 17 and Tox isolate 53 mono-cultures and during their interaction in co-culture. Aflatoxin production was reduced by 99.7% in 72 h co-cultures. Fewer than expected unique reads were assigned to Tox 53 during co-culture, indicating its …

Analysis Of The Photodegradation Of The Pro-Herbicide Benzobicyclon Hydrolysate Using A Seawater Gradient And Constituent Ions, Margaret A. Knight

Honors Capstones

No abstract provided.

Use Of Racial And Ethnic Categories In Medical Testing And Diagnosis: Primum Non Nocere, Jay S. Kaufman, Joanna Merckx, Richard S. Cooper

Faculty Publications

BACKGROUND: Use of race and ethnicity is common in medical tests and procedures, even though these categories are defined by sociological, historical, and political processes, and vary considerably in their definitions over time and place. Because all societies organize themselves around these constructs in some way, they are undeniable facets of the human experience, with myriad health consequences. In the biomedical literature, they are also commonly interpreted as representing biological heterogeneity that is relevant for health and disease. CONTENT: We review the use of race and ethnicity in medical practice, especially in the USA, and provide 2 specific examples to …

Physical Activity And Fat-Free Mass During Growth And In Later Life, Klaas R. Westerterp, Yosuke Yamada, Hiroyuki Sagayama, Philip N. Ainslie, Lene F. Andersen, Liam J. Anderson, Lenore Arab, Issaad Baddou, Kweku Bedu-Addo, Ellen E. Blaak, Stephane Blanc, Alberto G. Bonomi, Carlijn V.C. Bouten, Pascal Bovet, Maciej S. Buchowski, Nancy F. Butte, Stefan G.J.A. Camps, Graeme L. Close, Jamie A. Cooper, Sai K. Das, Richard Cooper, Lara R. Dugas, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W. Fudge, Annelies H. Goris, Michael Gurven, Catherine Hambly, Asmaa E. El Hamdouchi, Marije B. Hoos, Sumei Hu, Noorjehan Joonas

Faculty Publications

Background: Physical activity may be a way to increase and maintain fat-free mass (FFM) in later life, similar to the prevention of fractures by increasing peak bone mass. Objectives: A study is presented of the association between FFM and physical activity in relation to age. Methods: In a cross-sectional study, FFM was analyzed in relation to physical activity in a large participant group as compiled in the International Atomic Energy Agency Doubly Labeled Water database. The database included 2000 participants, age 3-96 y, with measurements of total energy expenditure (TEE) and resting energy expenditure (REE) to allow calculation of physical …

Resistance To Aflatoxin Accumulation In Maize Mediated By Host-Induced Silencing Of The Aspergillus Flavus Alkaline Protease (Alk) Gene, Olanike Omolehin, Yenjit Raruang, Dongfang Hu, Zhu Qiang Han, Qijian Wei, Kan Wang, Kanniah Rajasekaran, Jeffrey W. Cary, Zhi Yuan Chen

Faculty Publications

Aspergillus flavus is a fungal pathogen that infects maize and produces aflatoxins. Host-Induced Gene Silencing (HIGS) has been shown to reduce host infection by various fungal pathogens. Here, the A. flavus alkaline protease (alk) gene was targeted for silencing through HIGS. An RNAi vector carrying a portion of the alk gene was incorporated into the B104 maize genome. Four out of eight transformation events containing the alk gene, Alk-3, Alk-4, Alk-7 and Alk-9, were self-pollinated to T4/T6 generations. At T3, the Alk-transgenic lines showed up to 87% reduction in aflatoxin accumulation under laboratory conditions. T4 transgenic Alk-3 and Alk-7 lines, …

Effects Of Cover Crops On Beetle Assemblages In Tea Plantations, Li Lin Chen, Gabor Pozsgai, Xiang Yu Li, Lei Li, Gadi V.P. Reddy, Min Sheng You

Faculty Publications

Coleoptera are visible members of food webs in tea plantations, with high species richness and abundance. Many tea pests, as well as natural enemies, are members of this order, so a knowledge of how groundcovers affect beetles can aid pest management. We collected beetles in a replicated field experiment in the Wuyi Mountains, Fujian Province, China. Tea was intercropped with Paspalum notatum or Chamaecrista rotundifolia, or rows were cleared to bare ground, or in the control they were left unmanaged to allow weeds to grow naturally. Sampling, done by sweep netting and vegetation beating, was conducted monthly, between May 2006 …