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2021

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Loss Of Angiotensin Ii Type 2 Receptor Improves Blood Pressure In Elastin Insufficiency, Michelle Lin, Robyn A Roth, Beth A Kozel, Robert P Mecham, Carmen M Halabi Jan 2021

Loss Of Angiotensin Ii Type 2 Receptor Improves Blood Pressure In Elastin Insufficiency, Michelle Lin, Robyn A Roth, Beth A Kozel, Robert P Mecham, Carmen M Halabi

2020-Current year OA Pubs

There is ample evidence supporting a role for angiotensin II type 2 receptor (AT

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Led Illumination Spectrum Manipulation For Increasing The Yield Of Sweet Basil (Ocimum Basilicum L.), Md Momtazur Rahman, Mikhail Vasiliev, Kamal Alameh Jan 2021

Led Illumination Spectrum Manipulation For Increasing The Yield Of Sweet Basil (Ocimum Basilicum L.), Md Momtazur Rahman, Mikhail Vasiliev, Kamal Alameh

Research outputs 2014 to 2021

© 2021 by the authors. Licensee MDPI, Basel, Switzerland. Manipulation of the LED illumination spectrum can enhance plant growth rate and development in grow tents. We report on the identification of the illumination spectrum required to significantly enhance the growth rate of sweet basil (Ocimum basilicum L.) plants in grow tent environments by controlling the LED wavebands illuminating the plants. Since the optimal illumination spectrum depends on the plant type, this work focuses on identifying the illumination spectrum that achieves significant basil biomass improvement compared to improvements reported in prior studies. To be able to optimize the illumination spectrum, several …

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The Second World Ocean Assessment Volume 1, Jason Hall-Spencer, Louise Firth Jan 2021

The Second World Ocean Assessment Volume 1, Jason Hall-Spencer, Louise Firth

School of Biological and Marine Sciences

In its resolutions 57/141 and 58/240, the General Assembly decided to establish a regular processunder the United Nations for global reporting and assessment of the state of the marineenvironment, including socioeconomic aspects, both current and foreseeable, building on existingregional assessments. In its resolution 71/257, the Assembly recalled that the scope of thefirst cycle of the Regular Process focused on establishing a baseline and decided that the scopeof the second cycle would extend to evaluating trends and identifying gaps. The programme ofwork for the period 2017–2020 of the second cycle of the Regular Process includes the preparationby the Group of Experts …

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Policy Brief - Implementing Nature-Based Solutions For Enhancing Coastal Resilience In Malaysia, Abigail Mcquatters-Gollop, Louise Firth Jan 2021

Policy Brief - Implementing Nature-Based Solutions For Enhancing Coastal Resilience In Malaysia, Abigail Mcquatters-Gollop, Louise Firth

School of Biological and Marine Sciences

No abstract provided.

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Integrated Greening Of Grey Infrastructure (Iggi) To Enhance Biodiversity On Engineered Shorelines In Malaysia, Abigail Mcquatters-Gollop, Louise Firth Jan 2021

Integrated Greening Of Grey Infrastructure (Iggi) To Enhance Biodiversity On Engineered Shorelines In Malaysia, Abigail Mcquatters-Gollop, Louise Firth

School of Biological and Marine Sciences

No abstract provided.

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Balance Right In Multiple Sclerosis (Brims): A Feasibility Randomised Controlled Trial Of A Falls Prevention Programme, H. Gunn, K. N. Stevens, S. Creanor, J. Andrade, L. Paul, L. Miller, C. Green, P. Ewings, A. Barton, M. Berrow, J. Vickery, B. Marshall, J. Zajicek, J. A. Freeman Jan 2021

Balance Right In Multiple Sclerosis (Brims): A Feasibility Randomised Controlled Trial Of A Falls Prevention Programme, H. Gunn, K. N. Stevens, S. Creanor, J. Andrade, L. Paul, L. Miller, C. Green, P. Ewings, A. Barton, M. Berrow, J. Vickery, B. Marshall, J. Zajicek, J. A. Freeman

School of Health Professions

Abstract Background Balance, mobility impairments and falls are problematic for people with multiple sclerosis (MS). The “Balance Right in MS (BRiMS)” intervention, a 13-week home and group-based exercise and education programme, aims to improve balance and minimise falls. This study aimed to evaluate the feasibility of undertaking a multi-centre randomised controlled trial and to collect the necessary data to design a definitive trial. Methods This randomised controlled feasibility study recruited from four United Kingdom NHS clinical neurology services. Patients ≥ 18 years with secondary progressive MS (Expanded Disability Status Scale 4 to 7) reporting more than two falls in the …

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Cruciferous Vegetable Intake Is Inversely Associated With Extensive Abdominal Aortic Calcification In Elderly Women: A Cross-Sectional Study, Lauren C. Blekkenhorst, Marc Sim, Simone Radavelli Bagatini, Nicola P. Bondonno, Catherine P. Bondonno, Amanda Devine, John T. Schousboe, Wai H. Lim, Douglas P. Kiel, Richard J. Woodman, Jonathan M. Hodgson, Richard L. Prince, Joshua Lewis Jan 2021

Cruciferous Vegetable Intake Is Inversely Associated With Extensive Abdominal Aortic Calcification In Elderly Women: A Cross-Sectional Study, Lauren C. Blekkenhorst, Marc Sim, Simone Radavelli Bagatini, Nicola P. Bondonno, Catherine P. Bondonno, Amanda Devine, John T. Schousboe, Wai H. Lim, Douglas P. Kiel, Richard J. Woodman, Jonathan M. Hodgson, Richard L. Prince, Joshua Lewis

Research outputs 2014 to 2021

We have previously shown higher intake of cruciferous vegetables is inversely associated with carotid artery intima-media thickness. To further test the hypothesis that an increased consumption of cruciferous vegetables is associated with reduced indicators of structural vascular disease in other areas of the vascular tree, we aimed to investigate the cross-sectional association between cruciferous vegetable intake and extensive calcification in the abdominal aorta. Dietary intake was assessed, using a food frequency questionnaire, in 684 older women from the Calcium Intake Fracture Outcome Study. Cruciferous vegetables included cabbage, Brussels sprouts, cauliflower and broccoli. Abdominal aortic calcification (AAC) was scored using the …

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Ocean Acidification And Carbon Limitation Affect Photosynthetic Capacity Of The Seagrass (Amphibolis Antarctica) And Its Calcifying Epiphytes, Daniel Grove Jan 2021

Ocean Acidification And Carbon Limitation Affect Photosynthetic Capacity Of The Seagrass (Amphibolis Antarctica) And Its Calcifying Epiphytes, Daniel Grove

School of Biological and Marine Sciences Theses

Amphibolis antarctica seagrass meadows, and their associated calcifying epiphytes, are abundant on Australia’s west coast, but have declined in recent years due to anthropogenic factors such as marine heatwaves, damaging fishing practices and increased turbidity resulting from eutrophication which causes light limitation. Burning fossil fuels has increased the flux of CO2 in to the ocean, lowering surface seawater pH, and making more carbon available for photosynthetic life. There are benefits of increasing CO2 for those seagrasses that are carbon limited, as this alleviates their energetic use of carbon concentrating mechanisms (CCM’S) which are less efficient, and more energy costly than …

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Improved Htm Spatial Pooler With Homeostatic Plasticity Control, Damir Dobric, Andreas Pech, Bogdan Ghita, Thomas Wennekers Jan 2021

Improved Htm Spatial Pooler With Homeostatic Plasticity Control, Damir Dobric, Andreas Pech, Bogdan Ghita, Thomas Wennekers

School of Engineering, Computing and Mathematics

No abstract provided.

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Preliminary Development Of A Questionnaire To Measure The Extra-Pulmonary Symptoms Of Severe Asthma, Felice G De, Michael E. Hyland, Joseph W. Lanario, Yuri Antonacci, Rupert C. Jones, Matthew Masoli Jan 2021

Preliminary Development Of A Questionnaire To Measure The Extra-Pulmonary Symptoms Of Severe Asthma, Felice G De, Michael E. Hyland, Joseph W. Lanario, Yuri Antonacci, Rupert C. Jones, Matthew Masoli

School of Psychology

Abstract Background Research into the effects of asthma treatments on the extra-pulmonary symptoms of severe asthma is limited by the absence of a suitable questionnaire. The aim was to create a questionnaire suitable for intervention studies by selecting symptoms that are statistically associated with asthma pathology and therefore may improve when pathology is reduced. Methods Patients attending a specialist asthma clinic completed the 65-item General Symptom Questionnaire (GSQ-65), a questionnaire validated for assessing symptoms of people with multiple medically unexplained symptoms. Lung function (FEV1%) and cumulative oral corticosteroids (OCS) calculated from maintenance dose plus exacerbations were obtained from clinic records. …

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Ecotoxicology Of Active Ingredients In Changing Marine Environments, Cameron Hird Jan 2021

Ecotoxicology Of Active Ingredients In Changing Marine Environments, Cameron Hird

School of Biomedical Sciences

Active ingredients (AIs), including pesticides and pharmaceuticals, are designed to have a specific mode-of-action (MoA) in target organisms. Despite this, there is substantial evidence of their occurrence in marine environments having the potential to impact non-target species with effects both as a result of, and independent from, their MoA. Furthermore, due to a large proportion of AIs being readily ionisable, there is growing evidence that their uptake and effects are sensitive to environmental parameters such as pH, which can be driven by changes in pCO2,both in natural cycles and as a consequence of anthropogenic activities.In this thesis I investigate the …

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Seeing Lockdown Through The Eyes Of Children From Around The World: Reflecting On A Children's Artwork Project, S Neill, Mj Foster, M Al-Motlaq, B Carter, T O'Sullivan, A Quaye, M Majamanda, K Abdullah, Ik Hallstrom, C English, A Vickers, I Coyne, E Adama, E Morelius Jan 2021

Seeing Lockdown Through The Eyes Of Children From Around The World: Reflecting On A Children's Artwork Project, S Neill, Mj Foster, M Al-Motlaq, B Carter, T O'Sullivan, A Quaye, M Majamanda, K Abdullah, Ik Hallstrom, C English, A Vickers, I Coyne, E Adama, E Morelius

School of Nursing and Midwifery

The COVID-19 pandemic created new challenges for children including access to education and limiting social and emotional connections to extended family, friends, and the community. Globally, opportunities for sharing children’s self-reported experiences during lockdown were limited. The primary aim of this project was to create an art-E-Book that reflects children’s experiences of life during the COVID-19 pandemic that could be shared with other children around the world. Secondly, we wanted to reflect on the consultation undertaken within the International Network of Child and Family Centered Care (INCFCC) using Gibbs (1988) reflective cycle framework. Children from around the world were invited …

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An Investigation Into The Social Interaction And Demonstration Of Preference For Location Of Cows In A Commercial Dairy Herd., Joanne Vincent Jan 2021

An Investigation Into The Social Interaction And Demonstration Of Preference For Location Of Cows In A Commercial Dairy Herd., Joanne Vincent

School of Biological and Marine Sciences Theses

Under free-ranging conditions cattle live in social groups because it is beneficial to them in terms of risk of predation, breeding synchronisation and collective intelligence, amongst others. However, current dairy cattle management practice is not geared toward management of the cow for her social wellbeing but rather for the ability to feed and manage appropriately and meet the cows’ main needs that affect productivity and profitability. Domestic dairy cattle do not have free ranging opportunities. Heifers are managed in cohort groups from birth to calving and have little, if any, interaction with the adult herd until they calve. This study …

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The Importance Of Knowledge Exchange As A Method To Help Farmers Transition To Sustainable Farming Methods And Mitigate Climate Change., Rebecca Willson Jan 2021

The Importance Of Knowledge Exchange As A Method To Help Farmers Transition To Sustainable Farming Methods And Mitigate Climate Change., Rebecca Willson

School of Biological and Marine Sciences Theses

Climate change is among the world’s greatest challenges in the 21st century. This research aimed to evaluate the opportunities for knowledge exchange to support farmers in the transition to more sustainable farming practices. This study used a mixed method analysis to understand current views on knowledge exchange and identify barriers and drivers for farmers to change practice specifically focused on the provision of advice. Key informant interviews were completed with a range of participants involved in sustainable agriculture. To complement opinions from the interviews, farmers were surveyed at three on-farm events and an online survey for farm advisors was completed. …

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Soil Erosion And Sediment Transport In Tanzania: Part Ii – Sedimentological Evidence Of Phased Land Degradation, Maarten Wynants, Aloyce Patrick, Linus Munishi, Kelvin Mtei, Samuel Bodé, Alex Taylor, Geoffrey Millward, Neil Roberts, David Gilvear, Patrick Ndakidemi, Pascal Boeckx, William H. Blake Jan 2021

Soil Erosion And Sediment Transport In Tanzania: Part Ii – Sedimentological Evidence Of Phased Land Degradation, Maarten Wynants, Aloyce Patrick, Linus Munishi, Kelvin Mtei, Samuel Bodé, Alex Taylor, Geoffrey Millward, Neil Roberts, David Gilvear, Patrick Ndakidemi, Pascal Boeckx, William H. Blake

More Faculty of Science and Engineering Research

No abstract provided.

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Taking The Pulse Of Earth's Tropical Forests Using Networks Of Highly Distributed Plots, Forestplotsnet, Cecilia Blundo, Julieta Carilla, Ricardo Grau, A Malizia, L Malizia, Oriana Osinaga-Acosta, M Bird, Matt Bradford, Damien Catchpole, Andrew Ford, Andrew Graham, David Hilbert, Jeanette Kemp, S Laurance, W Laurance, Francoise Yoko Ishida, Andrew Marshall, Catherine Waite, Hannsjoerg Woell, Jean Francois Bastin, Marijn Bauters, Hans Beeckman, Pfascal Boeckx, Jan Bogaert, Canniere C De, Haulleville T De, Jean Louis Doucet, Olivier Hardy, Wannes Hubau, Elizabeth Kearsley, Hans Verbeeck, Jason Vleminckx, Steven W. Brewer, Alfredo Alarcón, Alejandro Araujo-Murakami, Eric Arets, Luzmila Arroyo, Ezequiel Chavez, Todd Fredericksen, René Guillén Villaroel, Gloria Gutierrez Sibauty, Timothy Killeen, Juan Carlos Licona, John Lleigue, C. Mendoza, Samaria Murakami, Alexander Parada Gutierrez, Guido Pardo, Marielos Peña-Claros, Lourens Poorter, Marisol Toledo, Jeanneth Villalobos Cayo, Laura Jessica Viscarra, Vincent Vos, Jorge Ahumada, E Almeida, J Almeida, A. De Oliveira, Fa Carvalho, Flávio Amorim Obermuller, Ana Andrade, Fa Carvalho, Sa Vieira, Ana Carla Aquino, Luiz Aragão, Ana Claudia Araújo, Marco Antonio Assis, Jose Ataliba Mantelli Aboin Gomes, Fabrício Baccaro, Pb De Camargo, Paulo Barni, Jorcely Barroso, Luis Carlos Bernacci, Kauane Bordin, Mb De Medeiros, Igor Broggio, José Luís Camargo, Domingos Cardoso, Maria Antonia Carniello, Andre Luis Casarin Rochelle, Carolina Castilho, Aajf Castro Jan 2021

Taking The Pulse Of Earth's Tropical Forests Using Networks Of Highly Distributed Plots, Forestplotsnet, Cecilia Blundo, Julieta Carilla, Ricardo Grau, A Malizia, L Malizia, Oriana Osinaga-Acosta, M Bird, Matt Bradford, Damien Catchpole, Andrew Ford, Andrew Graham, David Hilbert, Jeanette Kemp, S Laurance, W Laurance, Francoise Yoko Ishida, Andrew Marshall, Catherine Waite, Hannsjoerg Woell, Jean Francois Bastin, Marijn Bauters, Hans Beeckman, Pfascal Boeckx, Jan Bogaert, Canniere C De, Haulleville T De, Jean Louis Doucet, Olivier Hardy, Wannes Hubau, Elizabeth Kearsley, Hans Verbeeck, Jason Vleminckx, Steven W. Brewer, Alfredo Alarcón, Alejandro Araujo-Murakami, Eric Arets, Luzmila Arroyo, Ezequiel Chavez, Todd Fredericksen, René Guillén Villaroel, Gloria Gutierrez Sibauty, Timothy Killeen, Juan Carlos Licona, John Lleigue, C. Mendoza, Samaria Murakami, Alexander Parada Gutierrez, Guido Pardo, Marielos Peña-Claros, Lourens Poorter, Marisol Toledo, Jeanneth Villalobos Cayo, Laura Jessica Viscarra, Vincent Vos, Jorge Ahumada, E Almeida, J Almeida, A. De Oliveira, Fa Carvalho, Flávio Amorim Obermuller, Ana Andrade, Fa Carvalho, Sa Vieira, Ana Carla Aquino, Luiz Aragão, Ana Claudia Araújo, Marco Antonio Assis, Jose Ataliba Mantelli Aboin Gomes, Fabrício Baccaro, Pb De Camargo, Paulo Barni, Jorcely Barroso, Luis Carlos Bernacci, Kauane Bordin, Mb De Medeiros, Igor Broggio, José Luís Camargo, Domingos Cardoso, Maria Antonia Carniello, Andre Luis Casarin Rochelle, Carolina Castilho, Aajf Castro

More Faculty of Science and Engineering Research

Tropical forests are the most diverse and productive ecosystems on Earth. While better understanding of these forests is critical for our collective future, until quite recently efforts to measure and monitor them have been largely disconnected. Networking is essential to discover the answers to questions that transcend borders and the horizons of funding agencies. Here we show how a global community is responding to the challenges of tropical ecosystem research with diverse teams measuring forests tree-by-tree in thousands of long-term plots. We review the major scientific discoveries of this work and show how this process is changing tropical forest science. …

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Response To Ota, Allison And Fabinyi On ‘Evolving The Narrative For Protecting A Rapidly Changing Ocean, Post Covid‐19’, Dan Laffoley, John M. Baxter, Diva J. Amon, Joachim Claudet, Jm Hall‐Spencer, K Grorud‐Colvert, Lisa A. Levin, P. Chris Reid, Alex D. Rogers, Michelle L. Taylor, Lucy C. Woodall, Natalie F. Andersen Jan 2021

Response To Ota, Allison And Fabinyi On ‘Evolving The Narrative For Protecting A Rapidly Changing Ocean, Post Covid‐19’, Dan Laffoley, John M. Baxter, Diva J. Amon, Joachim Claudet, Jm Hall‐Spencer, K Grorud‐Colvert, Lisa A. Levin, P. Chris Reid, Alex D. Rogers, Michelle L. Taylor, Lucy C. Woodall, Natalie F. Andersen

More Faculty of Science and Engineering Research

No abstract provided.

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An Evaluation Of The Social And Economic Impact Of A Marine Protected Area On Commercial Fisheries, Se Rees, Matthew Ashley, Louisa Evans, Stephen Mangi, Emma V. Sheehan, Tom Mullier, A Rees, Martin J. Attrill Jan 2021

An Evaluation Of The Social And Economic Impact Of A Marine Protected Area On Commercial Fisheries, Se Rees, Matthew Ashley, Louisa Evans, Stephen Mangi, Emma V. Sheehan, Tom Mullier, A Rees, Martin J. Attrill

School of Biological and Marine Sciences

No abstract provided.

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Effects Of Dietary Additives On Growth Performance, Immunity And Mucosal Barrier Defences Of Salmonids, Nicola Pontefract Jan 2021

Effects Of Dietary Additives On Growth Performance, Immunity And Mucosal Barrier Defences Of Salmonids, Nicola Pontefract

School of Biological and Marine Sciences Theses

The mucosal surfaces of fish are considered highly active immunological sites that work to maintain homeostasis and play a key role in the defence against pathogens (Yu et al., 2020). While disease represents a major constraint to the aquaculture industry, the potential influence of dietary additives upon the mucosal barriers and defences of fish is the subject of increasing amounts of research. RT-q-PCR gene expression analysis and histological examinations of experiment one jointly indicate the potential of a dietary prebiotic mixture, a parabiotic and their synbiotic to positively influence the mucosal barrier defences of the Gill-(GIALT), Skin-(SALT) and Gut- associated …

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The Ecology And Distribution Of European Bass (Dicentrarchus Labrax) In Inshore And Coastal Waters Of The U.K., Thomas Stamp Jan 2021

The Ecology And Distribution Of European Bass (Dicentrarchus Labrax) In Inshore And Coastal Waters Of The U.K., Thomas Stamp

School of Biological and Marine Sciences Theses

European bass (Dicentrarchus labrax) is a commercially and recreationally important finfish native to the Northeast Atlantic and Mediterranean Sea. The species is targeted throughout its range and represents a significant commercial and recreational fishery, which in the UK are estimated to have a value of £5-6million at first sale, and £100-200 million per year respectively. In 2010, the International Council for Exploration of the Seas (ICES) reported a dramatic decline in the Northeast Atlantic stock (ICES divisions 4.b–c, 7.a, and 7.d–h), which in 2016 declined below “safe biological limits”. In 2019 ICES reported that the Northeast Atlantic stock increased above …

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Spatial Variation In The Gastrointestinal Microbiome, Diet, And Nutritional Condition Of A Juvenile Flatfish Among Coastal Habitats, Marc T. Morris, Chris Hauton, Alison J. Baylay, Luca Peruzza, Timothy E. Targett, Benjamin J. Ciotti Jan 2021

Spatial Variation In The Gastrointestinal Microbiome, Diet, And Nutritional Condition Of A Juvenile Flatfish Among Coastal Habitats, Marc T. Morris, Chris Hauton, Alison J. Baylay, Luca Peruzza, Timothy E. Targett, Benjamin J. Ciotti

School of Biological and Marine Sciences

No abstract provided.

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The Effectiveness Of Partially Protected Marine Areas For Ecosystem Based Management, Bede Ffinian Rowe Davies Jan 2021

The Effectiveness Of Partially Protected Marine Areas For Ecosystem Based Management, Bede Ffinian Rowe Davies

School of Biological and Marine Sciences Theses

The oceans provide highly important benefits to humans, ranging from sustenance and travel to livelihoods and spiritual wellbeing to climate stabilisation. Yet, globally the use of the marine environment has been unsustainable with extensive pressure being applied either directly or indirectly. This has led to the degradation of almost all marine ecosystems, with no system considered pristine from the depths of the Marianas trench to the inshore seas.Destabilisation of the ocean systems is jeopardising their ability to slow down the effects of climate change. This destabilisation is being driven in part by unsustainable and destructive human practises, such as: overfishing, …

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Predicting Dominance Of Sand Transport By Waves, Tides, And Their Interactions On Sandy Continental Shelves, E. V. King, D. C. Conley, G. Masselink, N. Leonardi Jan 2021

Predicting Dominance Of Sand Transport By Waves, Tides, And Their Interactions On Sandy Continental Shelves, E. V. King, D. C. Conley, G. Masselink, N. Leonardi

School of Biological and Marine Sciences

No abstract provided.

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Divergent Trajectories Of Cellular Bioenergetics, Intermediary Metabolism And Systemic Redox Status In Survivors And Non-Survivors Of Critical Illness, Helen T. Mckenna, Ka O’Brien, Bernadette O. Fernandez, Magdalena Minnion, Adam Tod, Ben D. Mcnally, James A. West, Julian L. Griffin, Michael P. Grocott, Michael G. Mythen, Martin Feelisch, Andrew J. Murray, Daniel S. Martin Jan 2021

Divergent Trajectories Of Cellular Bioenergetics, Intermediary Metabolism And Systemic Redox Status In Survivors And Non-Survivors Of Critical Illness, Helen T. Mckenna, Ka O’Brien, Bernadette O. Fernandez, Magdalena Minnion, Adam Tod, Ben D. Mcnally, James A. West, Julian L. Griffin, Michael P. Grocott, Michael G. Mythen, Martin Feelisch, Andrew J. Murray, Daniel S. Martin

Peninsula Medical School

BackgroundNumerous pathologies result in multiple-organ failure, which is thought to be a direct consequence of compromised cellular bioenergetic status. Neither the nature of this phenotype nor its relevance to survival are well understood, limiting the efficacy of modern life-support.MethodsTo explore the hypothesis that survival from critical illness relates to changes in cellular bioenergetics, we combined assessment of mitochondrial respiration with metabolomic, lipidomic and redox profiling in skeletal muscle and blood, at multiple timepoints, in 21 critically ill patients and 12 reference patients.ResultsWe demonstrate an end-organ cellular phenotype in critical illness, characterized by preserved total energetic capacity, greater coupling efficiency and …

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Plasticity Of Thermal Performance Curves In A Narrow Range Endemic Water Beetle, Susana Pallarés, Wilco C.E.P. Verberk, David T. Bilton Jan 2021

Plasticity Of Thermal Performance Curves In A Narrow Range Endemic Water Beetle, Susana Pallarés, Wilco C.E.P. Verberk, David T. Bilton

School of Biological and Marine Sciences

No abstract provided.

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A Feasibility Randomised Controlled Trial Of Targeted Oxygen Therapy In Mechanically Ventilated Critically Ill Patients, Daniel S. Martin, Margaret Mcneil, Chris Brew-Graves, Helder Filipe, Ronan O’Driscoll, Jia Liu Stevens, Rachel Burnish, Andrew F. Cumpstey, Norman R. Williams, Michael G. Mythen, Michael P.W. Grocott Jan 2021

A Feasibility Randomised Controlled Trial Of Targeted Oxygen Therapy In Mechanically Ventilated Critically Ill Patients, Daniel S. Martin, Margaret Mcneil, Chris Brew-Graves, Helder Filipe, Ronan O’Driscoll, Jia Liu Stevens, Rachel Burnish, Andrew F. Cumpstey, Norman R. Williams, Michael G. Mythen, Michael P.W. Grocott

Peninsula Medical School

Background Despite oxygen being the commonest drug administered to critically ill patients we do not know which oxygen saturation (SpO2) target results in optimal survival outcomes in those receiving mechanical ventilation. We therefore conducted a feasibility randomised controlled trial in the United Kingdom (UK) to assess whether it would be possible to host a larger national multi-centre trial to evaluate oxygenation targets in mechanically ventilated patients. Methods We set out to recruit 60 participants across two sites into a trial in which they were randomised to receive conservative oxygenation (SpO2 88–92%) or usual care (control – SpO2 ≥96%). The primary …

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Personality Assessment In Zoo-Housed Siamang Gibbons And Sulawesi Macaques., Lewis James Rowden Jan 2021

Personality Assessment In Zoo-Housed Siamang Gibbons And Sulawesi Macaques., Lewis James Rowden

School of Biological and Marine Sciences Theses

Personality, differences in individual behaviour that are consistent across time and situations, have relatively recently been determined in a wide range of non-human animals. As the existence of animal personality increases within the scientific literature, the scope for practical application of knowledge increases concurrently. This study aimed to investigate ways in which personality data can be applied to the ex-situ management of threatened primate species. The first part of this research quantified personality in the European zoo population of Symphalangus syndactylus, including validation of trait rating techniques. Personality data were then applied to the study of reproductive success. Secondly, the …

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Physiological Responses During Ascent To High Altitude And The Incidence Of Acute Mountain Sickness, Alexandra B. Cobb, Denny Z.H. Levett, K Mitchell, Wynne Aveling, D Hurlbut, E Gilbert‐Kawai, Philip J. Hennis, Mg Mythen, Michael P.W. Grocott, Ds Martin, V. Ahuja, G Aref‐Adib, R. Burnham, A. Chisholm, K. Clarke, D Coates, M Coates, D. Cook, M. Cox, S. Dhillon, C. Dougall, P. Doyle, P. Duncan, M. Edsell, L. Edwards, L. Evans, P. Gardiner, Michael P.W. Grocott, P. Gunning, J. Harrington, J. Harrington, J. Harvey, C. Holloway, D. Howard, D Hurlbut, C. Imray, C. Ince, Der Kaaij J Van, M. Khosravi, N. Kolfschoten, Denny Z.H. Levett, H Luery, A. Luks, D Martin, R. Mcmorrow, P. Meale, K Mitchell, H. Montgomery, G Morgan, J Morgan, A. Murray, M Mythen, S Newman, V O’Dwyer, J Pate, T Plant, V Pun, P Richards, A Richardson, G Rodway, J Simpson, C Stroud, M Stroud, J Stygal, B Symons, P Szawarski, Tulleken A Van, Tulleken C Van, A Vercueil, L Wandrag, M Wilson, J Windsor, B Basnyat, K. Clarke, T Hornbein, J Milledge, J West, S Abraham, T Adams, W Anseeuw, R Astin, B Basnyat, O Burdall, J Carroll, Alexandra B. Cobb, J Coppel, O Couppis, J Court, A Cumpstey, T Davies, S. Dhillon, N Diamond, C. Dougall, T Geliot, E Gilbert‐Kawai, G Gilbert‐Kawai, E Gnaiger, M Grocott, C Haldane, P Hennis, J Horscroft, D Howard, S Jack, B Jarvis, W Jenner, G Jones, J Van Der Kaaij, J Kenth, A Kotwica, R Kumar Bc, J Lacey, V Laner, D Levett, D Martin, P Meale, K Mitchell, Z Mahomed, J Moonie, A Murray, M Mythen, P Mythen, K O’Brien, I Ruggles‐Brice, K Salmon, A Sheperdigian, T Smedley, B Symons, C Tomlinson, A Vercueil, L Wandrag, S Ward, A Wight, C Wilkinson, S Wythe, M Feelisch, E Gilbert‐Kawai, M Grocott, M Hanson, D Levett, D Martin, K Mitchell, H Montgomery, R Moon, A Murray, M Mythen, M Peters Jan 2021

Physiological Responses During Ascent To High Altitude And The Incidence Of Acute Mountain Sickness, Alexandra B. Cobb, Denny Z.H. Levett, K Mitchell, Wynne Aveling, D Hurlbut, E Gilbert‐Kawai, Philip J. Hennis, Mg Mythen, Michael P.W. Grocott, Ds Martin, V. Ahuja, G Aref‐Adib, R. Burnham, A. Chisholm, K. Clarke, D Coates, M Coates, D. Cook, M. Cox, S. Dhillon, C. Dougall, P. Doyle, P. Duncan, M. Edsell, L. Edwards, L. Evans, P. Gardiner, Michael P.W. Grocott, P. Gunning, J. Harrington, J. Harrington, J. Harvey, C. Holloway, D. Howard, D Hurlbut, C. Imray, C. Ince, Der Kaaij J Van, M. Khosravi, N. Kolfschoten, Denny Z.H. Levett, H Luery, A. Luks, D Martin, R. Mcmorrow, P. Meale, K Mitchell, H. Montgomery, G Morgan, J Morgan, A. Murray, M Mythen, S Newman, V O’Dwyer, J Pate, T Plant, V Pun, P Richards, A Richardson, G Rodway, J Simpson, C Stroud, M Stroud, J Stygal, B Symons, P Szawarski, Tulleken A Van, Tulleken C Van, A Vercueil, L Wandrag, M Wilson, J Windsor, B Basnyat, K. Clarke, T Hornbein, J Milledge, J West, S Abraham, T Adams, W Anseeuw, R Astin, B Basnyat, O Burdall, J Carroll, Alexandra B. Cobb, J Coppel, O Couppis, J Court, A Cumpstey, T Davies, S. Dhillon, N Diamond, C. Dougall, T Geliot, E Gilbert‐Kawai, G Gilbert‐Kawai, E Gnaiger, M Grocott, C Haldane, P Hennis, J Horscroft, D Howard, S Jack, B Jarvis, W Jenner, G Jones, J Van Der Kaaij, J Kenth, A Kotwica, R Kumar Bc, J Lacey, V Laner, D Levett, D Martin, P Meale, K Mitchell, Z Mahomed, J Moonie, A Murray, M Mythen, P Mythen, K O’Brien, I Ruggles‐Brice, K Salmon, A Sheperdigian, T Smedley, B Symons, C Tomlinson, A Vercueil, L Wandrag, S Ward, A Wight, C Wilkinson, S Wythe, M Feelisch, E Gilbert‐Kawai, M Grocott, M Hanson, D Levett, D Martin, K Mitchell, H Montgomery, R Moon, A Murray, M Mythen, M Peters

Peninsula Medical School

No abstract provided.

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Exenatide Once Weekly Over 2 Years As A Potential Disease-Modifying Treatment For Parkinson’S Disease: Protocol For A Multicentre, Randomised, Double Blind, Parallel Group, Placebo Controlled, Phase 3 Trial: The ‘Exenatide-Pd3’ Study, Nirosen Vijiaratnam, Christine Girges, Grace Auld, Marisa Chau, Kate Maclagan, Alexa King, Simon Skene, Kashfia Chowdhury, Steve Hibbert, Huw Morris, Patricia Limousin, Dilan Athauda, Camille B. Carroll, Michele T. Hu, Monty Silverdale, Gordon W. Duncan, Ray Chaudhuri, Christine Lo, Din S Del, Alison J. Yarnall, Lynn Rochester, Rachel Gibson, John Dickson, Rachael Hunter, Vincenzo Libri, Thomas Foltynie Jan 2021

Exenatide Once Weekly Over 2 Years As A Potential Disease-Modifying Treatment For Parkinson’S Disease: Protocol For A Multicentre, Randomised, Double Blind, Parallel Group, Placebo Controlled, Phase 3 Trial: The ‘Exenatide-Pd3’ Study, Nirosen Vijiaratnam, Christine Girges, Grace Auld, Marisa Chau, Kate Maclagan, Alexa King, Simon Skene, Kashfia Chowdhury, Steve Hibbert, Huw Morris, Patricia Limousin, Dilan Athauda, Camille B. Carroll, Michele T. Hu, Monty Silverdale, Gordon W. Duncan, Ray Chaudhuri, Christine Lo, Din S Del, Alison J. Yarnall, Lynn Rochester, Rachel Gibson, John Dickson, Rachael Hunter, Vincenzo Libri, Thomas Foltynie

Peninsula Medical School

IntroductionParkinson’s disease (PD) is a common neurodegenerative disorder with substantial morbidity. No disease-modifying treatments currently exist. The glucagon like peptide-1 receptor agonist exenatide has been associated in single-centre studies with reduced motor deterioration over 1 year. The aim of this multicentre UK trial is to confirm whether these previous positive results are maintained in a larger number of participants over 2 years and if effects accumulate with prolonged drug exposure.Methods and analysisThis is a phase 3, multicentre, double-blind, randomised, placebo-controlled trial of exenatide at a dose of 2 mg weekly in 200 participants with mild to moderate PD. Treatment duration …

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Wave And Tide Influence On Headland Bypassing And Shelf Scale Sand Transport, Erin Victoria King Jan 2021

Wave And Tide Influence On Headland Bypassing And Shelf Scale Sand Transport, Erin Victoria King

School of Biological and Marine Sciences Theses

Waves and tidal currents resuspend and transport littoral and shelf sediments, and it is important to understand the processes impacting the net transport of sand, with implications for various topics including benthic habitats, marine operations, marine spatial planning, and long-term coastal change. Continental shelf areas comprise ~8% of global sea floor, and embayed beaches separated by rocky headlands represent 50% of global shorelines. These areas host a large proportion of global marine economic activity and recreation. Sandy sediments are potentially mobilised by wave-induced currents across > 40% of the earth’s shelf. Mobilised sediments are susceptible to net transport by tidal residual …

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