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A Pilot Study On Biological Characteristics Of Human Cd24(+) Stem Cells From The Apical Papilla, Jing Liang, Ya-Jin Zhao, Jun-Qing Li, Lan Lan, Wen-Jing Tao, Jia-Yuan Wu

Journal of Dental Sciences

Abstract Background/purpose CD24 is a specific cell surface marker for undifferentiated dental stem cells from apical papilla (SCAPs) seen only during root development, before the tooth emerges through gum. But the comprehensive role of CD24 in the SCAPs is unclear. This study aims to clarify the exact roles of CD24 in SCAPs. Materials and methods SCAPs were divided into CD24 (+)-SCAPs (high percentage CD24) and CD24 (-)-SCAPs (low percentage CD24) via flow cytometry. The proliferation, migration and osteogenic/adipogenic differentiation of the two groups were detected, RT-PCR was performed to detect the expression of osteogenic/adipogenic related genes and thegene expression were …

Enhanced Antimicrobial And Remineralizing Properties Of Self-Adhesive Orthodontic Resin Containing Mesoporous Bioactive Glass And Zwitterionic Material, Yong-Il Kim, Aerin Choi, Kyung-Hyeon Yoo, Seog-Young Yoon, Soo-Byung Park, Youn-Kyung Choi

Journal of Dental Sciences

Abstract Background/purpose Self-adhesive resins (SARs) do not require additional restorative adhesives and provide adequate adhesion to mineralized dental structures by shortening the bonding time in clinics where moisture control and isolation are difficult. The aim of this study was to evaluate the mechanical and biological properties of SARs containing mesoporous bioactive glass nanoparticles (MBNs) and 2-methacryloyloxyethyl phosphorylcholine (MPC) and to determine their antibacterial and remineralization effects. Materials and methods MBNs and MPC were added to SARs to improve their physical properties and remineralization ability. The experimental resins assessed in this study were SARs mixed with 3%MPC, 5%MPC, 1%MBN+3%MPC, or 3%MBN+3%MPC. …

Effects Of Treatment With Local Anesthetics On Rankl Expression In Mg63 And Pdl Cells, Chia-Tze Kao, Tsui Hsien Huang, Chien-Wei Chao

Journal of Dental Sciences

Abstract Background/purpose Local anesthesia (LA) application is a routine dental work in clinic. The aim of present study was to evaluate the extent of biologic effects of LA on periodontal ligaments (PDL) or bone cells (MG63). Materials and methods Local anesthetics (LAs) at different concentrations were added to PDL and MG 63 cells. The viability of the cells was analyzed using an MTT assay. The inflammatory markers, COX-2, IL-1, IL-6 and TNF-A, of PDL and MG63 cells treated with LAs were analyzed with a Western blot assay. The extract medium of the LA-treated PDL cells was added to the MG63 …

The Role Of Dopamine Signaling In Prairie Vole Peer Relationships, Nicole S. Lee, Annaliese K. Beery

Psychology: Faculty Publications

Dopamine signaling mediates the formation of some types of social relationships, including reproductive pair bonds in the socially monogamous prairie vole (Microtus ochrogaster). In addition to these pair bonds with mates, prairie voles demonstrate selective preferences for familiar same-sex peers. The dependence of peer relationships on dopamine signaling has not been tested, and the mechanisms supporting these relationships may differ from those underlying pair bonds. We examined the effects of pharmacological manipulations of dopamine signaling on peer partner preference and socially conditioned place preference in female prairie voles. Haloperidol blockade of dopamine receptors at multiple doses did not alter selective …

Traumatized Systems Theory: Accountability For Recurrent Systemic Harm, E. Christi Cunningham

Case Western Reserve Law Review

No abstract provided.

Cats At The Christening: Bundled Rebates, Doctrinal Blind Spots, And The Risks Of Antitrust Under-Enforcement In The Biologic Pharmaceutical Market, Benjamin Hayes

University of Memphis Law Review

No abstract provided.

Globe And Natural Inquirer Crosswalk Upper Elementary: Phenology, Eliza Balch, Globe U.S. Coordination Office

Teacher Resources

No abstract provided.

2020 U.S. Globe Partner Yearbook, Globe U.S. Coordination Office

Partner Yearbooks

No abstract provided.

Stuck Kids: Fostering Permanence For Families Receiving Services Through The Massachusetts Department Of Mental Health, Molly Houston

OTD DEx Reports - College of Pharmacy and Health Sciences

"Residential housing has become the last resort for young people who cannot receive the support and/or safety they need from their own families or from foster families, or who pose a danger to others. While residential housing can be highly effective at its initial purpose of providing respite and training for families and children, some children become long-term residents of these care institutions, spending years or even aging out while living in residential care. Research has demonstrated negative outcomes in the social, medical, emotional, and economic domains of out-of-home care as a permanent solution for children. Similar to many agencies …

Northeastern Illinois University, Academic Catalog 2021-2022, Northeastern Illinois University

Course Catalogs

No abstract provided.

Optimism Towards Space Activity Despite Past Earthly Injustices, Benjamin Switala

Masters Essays

No abstract provided.

Genetic Risk Factors For Alzheimer’S Disease In Racial/Ethnic Minority Populations In The U.S.: A Scoping Review, Lindsey Rubin, Lucy Annang Ingram Phd, Nicholas V. Resciniti, Brianna Ashford-Carroll, Katherine Henrietta Leith, Aubrey Rose, Stephanie Ureña, Quentin Mccollum, Daniela B. Friedman

Faculty Publications

As the United States (U.S.) population rapidly ages, the incidence of Alzheimer's Disease and Related Dementias (ADRDs) is rising, with racial/ethnic minorities affected at disproportionate rates. Much research has been undertaken to test, sequence, and analyze genetic risk factors for ADRDs in Caucasian populations, but comparatively little has been done with racial/ethnic minority populations. We conducted a scoping review to examine the nature and extent of the research that has been published about the genetic factors of ADRDs among racial/ethnic minorities in the U.S. Using an established scoping review methodological framework, we searched electronic databases for articles describing peer-reviewed empirical …

Restriction Of Access To Deep Brain Stimulation For Refractory Ocd: Failure To Apply The Federal Parity Act, Rachel Davis, James Giordano, D Brian Hufford, Sameer A. Sheth, Peter Warnke, Alik S. Widge, R Mark Richardson, Joshua M. Rosenow, Peter Justin Rossi, Eric A. Storch, Helena Winston, Joanne Zboyan, Darin D. Dougherty, Kelly D. Foote, Wayne K. Goodman, Nicole C. Mclaughlin, Steven Ojemann, Steven Rasmussen, Aviva Abosch, Michael S. Okun

Faculty Publications

No abstract provided.

Post-Bariatric Surgery Patients Fail To Exercise Consistently: Exploring The Potential Role Of Self-Compassion, Naomi Teeter

EWU Masters Thesis Collection

Many bariatric weight loss surgery patients do not exercise after surgery. One potential reason this population may not exercise is due to body image shame and low self-compassion, which can contribute to lower appreciation for one’s body. Adult participants from an international bariatric population sample (N = 805) and an Eastern Washington University undergraduate student sample (N = 104) completed a one-time online questionnaire that included measures of self-compassion, physical activity frequency, body appreciation, and body image shame. In the bariatric sample, self-compassion was indirectly associated with exercise frequency via body appreciation and body image shame. Additionally, at the highest …

Change In The Behaviors And Spatial Use Of Canada Lynx (Lynx Canadensis) Over Time At John Ball Zoo, Hailee Cederquist

Student Summer Scholars Manuscripts

Felines are popular attractions at zoos across the country, even more so when young animals are involved. As such caretakers strive to ensure that their animal’s needs are met, and individuals display healthy behaviors and activity levels in comparison to their wild counterparts (Mcphee & Carlstead, 2010). However, cats, being wide-ranging carnivores, are known to be prone to stereotypical behaviors which can be detrimental to an animal’s health (Clubb & Mason, 2003). At John Ball Zoo in Grand Rapids, Michigan, we observed the behaviors and spatial use of 3 Canada lynx (Lynx canadensis) during the summer of 2020; an adult …

Art And Biochemistry Applied To Snakebite Treatment: Medical Illustration And Biochemical Investigations Of The Bacterial Production Of Metalloproteinase Inhibitors From The North American Opossum D. Virginiana, Allison Soffa

Student Summer Scholars Manuscripts

Various opossum species are resistant to snake venoms due to the presence of antihemorrhagic and antimyotoxic acidic serum glycoproteins that inhibit several toxic venom components. Snake-bite envenomation is a global health concern, and a better understanding of these proteins may provide useful insight to determine their mechanism of action and for the development of therapeutics Two identical antihemorrhagic proteins, termed oprin or DM43, isolated from either the North American opossum (D. virginiana) or the South American bigeared opossum (D. aurita), inhibit specific snake venom metalloproteinases (SVMPs). The aim of this work is to produce a recombinant snake venom metalloproteinase inhibitor …

Investigating Tolfenamic Acid And Its Analogs As Potential Alzheimer’S Disease Therapeutics, Jaunetta Hill

Open Access Dissertations

Dementia is an umbrella term describing several diseases which cause cognitive impairment, confusion, difficulty completing tasks and social withdrawal. Alzheimer’s disease (AD) is the most common form of dementia, and the incidence is rapidly increasing as the ‘baby boomers’ age. Currently, there is one disease-modifying treatment approved for AD patients, however, its ability to decrease or reverse cognitive decline has yet to be confirmed.

The etiology of AD is unknown, however, there are two forms of AD associated with onset age. Early-onset AD (EOAD) is considered genetic and accounts for less than 5% of AD cases worldwide. Typically, EOAD is …

Entry And Replication Of Negative-Strand Rna Viruses, Kerri Boggs

Theses and Dissertations--Molecular and Cellular Biochemistry

Hendra virus (HeV) and human metapneumovirus (HMPV) are negative-sense, singled-stranded RNA viruses. The paramyxovirus HeV is classified as a biosafety level 4 pathogen due to its high fatality rate and the lack of a human vaccine or antiviral treatment. HMPV is a widespread pneumovirus that causes respiratory tract infections which are particularly dangerous for young children, immunocompromised individuals, and the elderly. Like HeV, no vaccines or therapies are available to combat HMPV infections. These viruses fuse their lipid envelopes with a cell to initiate infection. Blocking cell entry is a promising approach for antiviral development, and many vaccines are designed …

A Biochemical Characterization Of The Fusion Proteins From Enveloped Rna Viruses, Chelsea T. Barrett

Theses and Dissertations--Molecular and Cellular Biochemistry

Enveloped viruses must bind target cells and then fuse the viral membrane with a cell membrane to enter a host cell. These viruses use one or more surface glycoproteins to carry out these critical functions. The surface glycoprotein that carries out the fusion function, termed a fusion protein, is divided into three classes based on structural similarities. Some of the most studied human viral pathogens, such as human immunodeficiency virus (HIV), Ebola virus, influenza, measles, and the recently emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), possess class I fusion proteins. Following synthesis, class I fusion proteins associate as non-covalently …

Entry And Early Infection Of Non-Segmented Negative Sense Rna Viruses, Jean Mawuena Branttie

Theses and Dissertations--Molecular and Cellular Biochemistry

Paramyxoviruses, pneumoviruses, and other non-segmented negative sense (NNS) RNA viruses have historically been of public health concern. Although their genomes are typically small (up to 19kbs) they are able to inflict large-scale detrimental pathologies on host cells. Human metapneumovirus (HMPV) is a widespread pathogen and is a NNS RNA virus. HMPV results respiratory tract infections and is particularly dangerous for preterm infants, the elderly, and immunocompromised individuals. Other viruses within the NNS RNA virus order include the deadly Ebola, Hendra, and Nipah viruses (EBOV, HeV, and NiV), as well as the re-emerging measles virus (MeV). Despite their public impact, there …

Therapeutic Targeting Of Leukemia Stem Cells To Prevent T-Cell Acute Lymphoblastic Leukemia Relapse, Meghan G. Haney

Theses and Dissertations--Molecular and Cellular Biochemistry

The survival rate of T-cell Acute Lymphoblastic Leukemia (T-ALL) relapse is a dismal 10% of affected adults and 30% of children, largely due to the relapsed disease being more aggressive and treatment resistant than the initial disease. Relapse is thought to occur because conventional chemotherapies are unable to reliably eliminate a unique cell type known as leukemia stem (or propagating) cells (LSCs). LSCs are the only cells within the leukemia with the ability to self-renew and remake or replenish the ALL from a single cell. Currently, the pathways governing self-renewal in LSCs are largely unknown, precluding our ability to successfully …

Substrate Trafficking Within The Type Vii Secretion Systems Of Pathogenic Mycobacteria, Zachary A. Williamson

Theses and Dissertations--Molecular and Cellular Biochemistry

Tuberculosis (TB), primarily caused by infection of Mycobacterium tuberculosis (Mtb) in the lungs, is the deadliest infectious bacterial disease killing 1.5 million people annually. A major determinant of virulence is active secretion through three specialized type VII secretion (ESX) systems; ESX-1, ESX-3, and ESX-5. A large group of substrates exported by the ESX systems is the PE (Proline-Glutamine) and PPE (Proline-Proline-Glutamate) families of proteins, which are highly expanded in the pathogenic species of Mycobacteria and encompass over 7% of Mtb’s genome coding capacity. PE and PPE proteins interact together to form PE-PPE heterodimers, and are secreted through …

Reversible Glucan Phosphorylation In The Red Alga, Cyanidioschyzon Merolae, Corey Owen Brizzee

Theses and Dissertations--Molecular and Cellular Biochemistry

Starch and glycogen are an essential component for the majority of species and have been developed to maintain homeostasis in response to environmental changes. Water-soluble glycogen is an excellent source of quick, short-term energy in response to energy demands. In contrast, plants and algae have developed the macromolecule starch that is elegantly suitable for their dependence on external circumstances. Semi-crystalline starch is water-insoluble and inaccessible to most amylolytic enzymes, thus plants and algae have developed a coordinated system so that these enzymes can gain access to the denser starch energy cache. Starch-like semi-crystalline polysaccharides are also found in red algae, …

Feeling Good: Happiness And Health In Dutch Older Adults, Joshua Ray Tanzer

Open Access Dissertations

Statement of the problem: Positive psychology research has sought to identify cost efficient and intuitive ways to increase subjective happiness, with broad implications to personal health and overall quality of life (Lee Duckworth, Steen, & Seligman, 2005; Rashid, 2009; Seligman, 2008; Seligman, Ernst, Gillham, Reivich, & Linkins, 2009; Seligman, Rashid, & Parks, 2006). A complication in this research has been conflicting findings in the longitudinal stability of happiness (Easterlin, 2006). This analysis examines age related changes in happiness and physiological immune responsiveness to clarify the implications of positive health interventions.

Methods: Pretest-posttest structural equation modeling is employed to examine longitudinal …

True Crime, Women, And Sensationalized Representations In The Italian American Imaginary, Francesca Borrione

Open Access Dissertations

This dissertation explores American true crime literary and visual narratives and focuses on historical cases involving Italian American women and the cross-cultural relations between Italy and the United States from the late-nineteenth century to the beginning of the twenty-first century. I investigate the influence of true crime narratives on the popular imagination, with attention to the construction of ethnicity, class, and gender. The focus on Italian American women functions as a case study to discuss the impact and persistence of racialized assumptions and cultural stereotypes in American literature and cinema and explores the resistance of women to the dominant narrative. …

Anti-Inflammatory Effects Of Polyphenol-Enriched Extracts, Chang Liu

Open Access Dissertations

Our laboratory initiated a comprehensive research program to investigate the phytochemical composition and biological effects of several botanical based natural products including pomegranate (Punica granatum), red maple (Acer rubrum), polyphenol-enriched maple (Acer saccharum) syrup extract, and various phytocannabinoids (Cannabis sp.). We hypothesize that these bioactive natural products can exert beneficial biological effects via their antioxidant and anti-inflammatory effects.

In Manuscript 1-4, we identified a series of phytochemicals from botanical extracts including pomegranate, red maple, phenolic-enriched maple syrup extract (MSX) and evaluated their biological activities for potential cosmeceutical and/or dermatological applications. In …

Cigarette Smoke Stimulates Sars-Cov-2 Internalization By Activating Ahr And Increasing Ace2 Expression In Human Gingival Epithelial Cells, Cassio Luiz Coutinho Almeida-Da-Silva, Harmony Matshik Dakafay, Kaitlyn Liu, David M. Ojcius

All Dugoni School of Dentistry Faculty Articles

A large body of evidence shows the harmful effects of cigarette smoke to oral and systemic health. More recently, a link between smoking and susceptibility to coronavirus disease 2019 (COVID-19) was proposed. COVID-19 is due to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which uses the receptor ACE2 and the protease TMPRSS2 for entry into host cells, thereby infecting cells of the respiratory tract and the oral cavity. Here, we examined the effects of cigarette smoke on the expression of SARS-CoV-2 receptors and infection in human gingival epithelial cells (GECs). We found that cigarette smoke condensates (CSC) upregulated …

Colorism Experiences Of Non-White Women Leaders In Higher Education, Aimee Haynes

Department of Conflict Resolution Studies Theses and Dissertations

As the population of the United States becomes more diverse the ethnic makeup of postsecondary institutions expands. Women of color (WOC) represent a growing number within the academic community earning more postsecondary degrees then men and serve as leaders in higher education throughout the county. The increased presence of WOC inacademic positions of power, such as deans, directors, supervisors, tenured faculty, presidents, etc., indicate America’s progression towards inclusivity. However, colorism, a subset of racism favoring and advantaging lighter skin complexions and disadvantaging darker skin tones, exist as a predictor of socioeconomic status, educational attainment, martial capital, occupational, and interpersonal success …

Women As College And University Presidents: Sharpening The Needle, Janell Emmaline Gibson

Department of Conflict Resolution Studies Theses and Dissertations

Women are underrepresented as college and university (school) presidents and currently hold about 30% of school presidencies. In 2014, the American Council on Education (ACE) launched an initiative to achieve gender parity among U.S. school presidencies by 2030. To support this initiative, Dr. Belle Wheelan, president of the Southern Association of Colleges and Schools Commission on Colleges (SACSCOC), challenged member institutions to support ACE’s initiative in achieving gender parity among school presidents by 2030. The boards of trustees hire school presidents and play a pivotal role in achieving gender parity. The research addresses a gap in literature examining if there …

Nutrition & Dietetics Bs, Nutrition & Dietetics

Program Revisions/Additions

No abstract provided.