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Anti-Inflammatory Effects Of Polyphenol-Enriched Extracts, Chang Liu

Open Access Dissertations

Our laboratory initiated a comprehensive research program to investigate the phytochemical composition and biological effects of several botanical based natural products including pomegranate (Punica granatum), red maple (Acer rubrum), polyphenol-enriched maple (Acer saccharum) syrup extract, and various phytocannabinoids (Cannabis sp.). We hypothesize that these bioactive natural products can exert beneficial biological effects via their antioxidant and anti-inflammatory effects.

In Manuscript 1-4, we identified a series of phytochemicals from botanical extracts including pomegranate, red maple, phenolic-enriched maple syrup extract (MSX) and evaluated their biological activities for potential cosmeceutical and/or dermatological applications. In …

Cigarette Smoke Stimulates Sars-Cov-2 Internalization By Activating Ahr And Increasing Ace2 Expression In Human Gingival Epithelial Cells, Cassio Luiz Coutinho Almeida-Da-Silva, Harmony Matshik Dakafay, Kaitlyn Liu, David M. Ojcius

All Dugoni School of Dentistry Faculty Articles

A large body of evidence shows the harmful effects of cigarette smoke to oral and systemic health. More recently, a link between smoking and susceptibility to coronavirus disease 2019 (COVID-19) was proposed. COVID-19 is due to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which uses the receptor ACE2 and the protease TMPRSS2 for entry into host cells, thereby infecting cells of the respiratory tract and the oral cavity. Here, we examined the effects of cigarette smoke on the expression of SARS-CoV-2 receptors and infection in human gingival epithelial cells (GECs). We found that cigarette smoke condensates (CSC) upregulated …

Colorism Experiences Of Non-White Women Leaders In Higher Education, Aimee Haynes

Department of Conflict Resolution Studies Theses and Dissertations

As the population of the United States becomes more diverse the ethnic makeup of postsecondary institutions expands. Women of color (WOC) represent a growing number within the academic community earning more postsecondary degrees then men and serve as leaders in higher education throughout the county. The increased presence of WOC inacademic positions of power, such as deans, directors, supervisors, tenured faculty, presidents, etc., indicate America’s progression towards inclusivity. However, colorism, a subset of racism favoring and advantaging lighter skin complexions and disadvantaging darker skin tones, exist as a predictor of socioeconomic status, educational attainment, martial capital, occupational, and interpersonal success …

Women As College And University Presidents: Sharpening The Needle, Janell Emmaline Gibson

Department of Conflict Resolution Studies Theses and Dissertations

Women are underrepresented as college and university (school) presidents and currently hold about 30% of school presidencies. In 2014, the American Council on Education (ACE) launched an initiative to achieve gender parity among U.S. school presidencies by 2030. To support this initiative, Dr. Belle Wheelan, president of the Southern Association of Colleges and Schools Commission on Colleges (SACSCOC), challenged member institutions to support ACE’s initiative in achieving gender parity among school presidents by 2030. The boards of trustees hire school presidents and play a pivotal role in achieving gender parity. The research addresses a gap in literature examining if there …

Nutrition & Dietetics Bs, Nutrition & Dietetics

Program Revisions/Additions

No abstract provided.

Exercise Science Pre-Occupational Therapy, Ksr

Program Revisions/Additions

No abstract provided.

Clinical Laboratory Science Major, Biological Sciences

Program Revisions/Additions

No abstract provided.

Cds Minor, Cds

Program Revisions/Additions

No abstract provided.

“Insurance Doesn’T Care About The Patient”: An Institutional Ethnography Of The Influence Of Professional Autonomy On The Provision Care For Medicaid Dental Patients With Disabilities, Stephanie Lau

Theses and Dissertations

In terms of unmet needs for people with disabilities (PWD), dental care is number three behind residential care and employment (Fisher, 2012). Regardless of disability, oral healthcare traverses all disability diagnoses and can be a significant factor in quality of life (Deckler, 2011; Griffin et al., 2007; Norwood & Slayton, 2013). When attempting to secure oral healthcare, people with disabilities face many challenges, including lack of access, lack of provider education on proper care of PWD, and difficulty finding a willing dental provider (Deckler, 2011; Fisher, 2012; Kennedy, 2009).

The purpose of this study was to investigate professional practices and …

Development Of Analytical Methods For Analysis Of Glycosaminoglycans And Their Mimetics In Human Plasma, Rawan M. Fayyad

Theses and Dissertations

Glycosaminoglycans (GAGs) are linear, polydisperse polysaccharides consisting of alternating amino sugars and either a uronic acid or galactose residue. They are ubiquitous components of the extracellular matrix and are present on cell surfaces and in basement membranes. GAGs are highly negatively charged as a result of many sulfate and carboxylic acid groups, and are extremely heterogeneous in both their structure and in their physicochemical properties. This complexity in structure is attributed to the alterations in residue types, glycosidic bond linkage, sulfation levels, sulfation positions, and chain lengths during biosynthesis. GAGs interact with a wide number of proteins and modulate various …

The Role Of Autophagy And Senescence In The Responses Of Non-Small Cell Lung Cancer Cells To Chemotherapy And Radiation, Nipa H. Patel

Theses and Dissertations

Cancer-associated deaths account for the second-highest mortality rates in the United States. Primary modalities of treatment often include surgery, radiation, and chemotherapy, and may also incorporate targeted therapy and immunotherapy. However, resistance to these treatments remains high, resulting in disease reoccurrence and poor survival rates. While apoptosis or cell death of tumor cells is the ideal outcome for anti-cancer therapy, this is often not the case, and in fact cancer cells may upregulate several pathways, such as autophagy and senescence, as a means to undergo alternative cell fate and evade apoptotic cell death. An essential tumor suppressor gene, TP53, …

Bisphosohoglycertae Mutase: A Potential Target For Sickle Cell Disease, Anfal S. Aljahdali

Theses and Dissertations

Bisphosphoglycerate mutase (BPGM) is a part of the erythrocyte glycolysis system. Specifically, it is a central enzyme in the Rapoport-Leubering pathway, a side glycolytic pathway involved in the regulation of the concentration of the natural allosteric effector of hemoglobin (Hb), 2,3-bisphosphoglycerate (2,3-BPG). BPGM catalyses the synthesis and hydrolysis of 2,3-BPG through its synthase and phosphatase activities. The synthase activity is the main role of BPGM, while the phosphatase activity is low and is activated by the physiological effector, 2-phosphoglycolate (2-PG) with the latter mechanism poorly understood.

BPGM activity and 2,3-BPG levels in red blood cells (RBCs) have a significant role …

Learning-Based Predictive Control Approach For Real-Time Management Of Cyber-Physical Systems, Roja Eini

Theses and Dissertations

Cyber-physical systems (CPSs) are composed of heterogeneous, and networked hardware and software components tightly integrated with physical elements [72]. Large-scale CPSs are composed of complex components, subject to uncertainties [89], as though their design and development is a challenging task. Achieving reliability and real-time adaptation to changing environments are some of the challenges involved in large-scale CPSs development [51]. Addressing these challenges requires deep insights into control theory and machine learning. This research presents a learning-based control approach for CPSs management, considering their requirements, specifications, and constraints. Model-based control approaches, such as model predictive control (MPC), are proven to be …

Glycosaminoglycan Modulation Of Key Proteins In Alzheimer's Disease, Tamim Chiba

Theses and Dissertations

Glycosaminoglycans (GAGs) are linear polysaccharides whose disaccharide building blocks consist of an amino sugar (D-glucosamine) and either uronic acid (D-glucuronic acid or L-iduronic acid) or galactose. Nearly all GAGs (with the exception of hyaluronic acid) are covalently attached to proteins, forming proteoglycans, and are ubiquitous in nature. The monomeric units, chain length, degree and pattern of sulfation, and epimerization are important properties that determine the influence of these molecules. Through Coulombic forces, hydrogen bonds and hydrophobic interactions, they regulate many physiological and pathophysiological processes such as blood coagulation, cell growth and differentiation, inflammatory processes, host defense and viral infection mechanisms. …

Regulation Of Osseous Healing By Macrophage-Derived Wnt Ligands, Jefferson Overlin Abaricia

Theses and Dissertations

Osseous healing is regulated by various classes of cells and signaling mechanisms. Of these, Wnt signaling has long been known to be critically important in directing the differentiation of mesenchymal stem cells (MSCs) into osteoblasts during bone healing. However, the source of these Wnt ligands is not known. Recently, a body of literature has arisen finding both beneficial and detrimental effects of macrophage-derived Wnt ligands on the regeneration of other tissues (liver, kidney, heart, and intestine), often by regulating inflammatory activation and stem cell behavior. As macrophages have been well-characterized as orchestrators of healing, their use of Wnt signaling to …

Implementing Ecosystem-Based Management, Brian Gray, Jennifer L. Harder, Karrigan Bork

McGeorge School of Law Scholarly Articles

Most freshwater ecosystems in the United States are in a state of collapse. Existing management efforts take a piecemeal approach, addressing individual stressors, managing the systems for individual benefits, and protecting individual species. These disjointed efforts are doomed to fail. Both the legal literature and the scientific literature are rich with articles extolling the advantages of ecosystem-based management; that is, simultaneous management of water, land, and organisms to achieve a desired ecosystem condition benefiting both native biodiversity and human well-being. This approach has succeeded in other aquatic systems, particularly marine ecosystems, but the ecosystem-based management approach has struggled for adoption …

Intermittent Theta Burst Stimulation: Application To Spinal Cord Injury Rehabilitation And Computational Modeling, Neil Mittal

Theses and Dissertations

Loss of motor function from spinal cord injuries (SCI) results in loss of independence. Rehabilitation efforts are targeted to enhance the ability to perform activities of daily living (ADLs), but outcomes from physical therapy alone are often insufficient. Neuromodulation techniques that induce neuroplasticity may push the limits on recovery. Neuromodulation by intermittent theta burst transcranial magnetic stimulation (iTBS) induces neuroplasticity by increasing corticomotor excitability, though this has most frequently been studied with motor targets and on individuals not in need of rehabilitation. Increased corticomotor excitability is associated with motor learning. The response to iTBS, however, is highly variable and unpredictable, …

Bacteriophage Therapy Of Bacterial Infections: The Rediscovered Frontier, Nejat Düzgüneş, Melike Sessevmez, Metin Yildirim

All Dugoni School of Dentistry Faculty Articles

Antibiotic-resistant infections present a serious health concern worldwide. It is estimated that there are 2.8 million antibiotic-resistant infections and 35,000 deaths in the United States every year. Such microorganisms include Acinetobacter, Enterobacterioceae, Pseudomonas, Staphylococcus and Mycobacterium. Alternative treatment methods are, thus, necessary to treat such infections. Bacteriophages are viruses of bacteria. In a lytic infection, the newly formed phage particles lyse the bacterium and continue to infect other bacteria. In the early 20th century, d’Herelle, Bruynoghe and Maisin used bacterium-specific phages to treat bacterial infections. Bacteriophages are being identified, purified and developed as pharmaceutically acceptable macromolecular “drugs,” undergoing strict quality …

Effects Of Fluoxetine/Simvastatin/Ascorbic Acid Combination Treatment On Neurogenesis And Functional Recovery In A Model Of Multiple Sclerosis, Olivia Cameron Webb

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Whereas immune modulation has proven beneficial in multiple sclerosis (MS), we hypothesized that targeting down-stream modulators of neurogenesis and subsequent remyelination may offer an additional, if not superior, point of intervention in an attempt to repair damage and recover lost function. As such, the present study assessed the effectiveness of 30-day administration of the drug combination fluoxetine (5 mg/kg), simvastatin (1 mg/kg), and ascorbic acid (50 mg/kg) (FSA) on an early marker of neurogenesis, doublecortin (DCX), and functional recovery using the Montoya Staircase following lysolecithin-induced focal demyelination of the corpus callosum in middle-aged (10-11 month) male and female rats. Lysolecithin …

The Protective Effects Of Mir-210 Modified Endothelial Progenitor Cells Released Exosomes In Hypoxia/Reoxygenation Injured Neurons, Sri Meghana Yerrapragada

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Endothelial progenitor cells (EPCs) have been shown to provide beneficial effects on oxidative stress. Exosomes (EXs) released from these stem cells could be one of the major contributors, as they are known to convey the benefit of one cell to another cell via microRNAs (miRNA). At first, we determined that EPCs release more EXs when they are serum-starved for 48 hours., and by determining the microRNA-210 (miR-210) levels in the EXs, we found that miRNA is being transferred from cells to EXs. Meanwhile, miR-210 is gaining popularity in reducing elevated oxidative stress levels. In this study, we investigated the role …

Analyses Of Coyote (Canis Latrans) Consumption Of Anthropogenic Material And Dietary Composition In Urban And Non-Urban Habitats, Audrey A. Hayes

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Coyotes are a generalist species that have adapted to nearly every terrestrial habitat in the United States. The species’ success is heavily attributed to their omnivorous diets and tolerance for environments that are regularly disturbed. Because the larger predator species that typically act as apex predators are sensitive to highly fragmented landscapes, the coyote is the functioning apex predator in many ecosystems where large predators, such as wolves, have been extirpated. The coyotes’ ecological role in urban ecosystems has received much attention in the last few decades as the species’ presence in cities and suburbs has increased, along with human-coyote …

Using Functionalized Benzylidene Oxindoles To Determine An Improved Monoamine Oxidase-B Inhibitor As A Therapeutic Agent For Parkinson's Disease, Christine Morgan Kinstedt

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With the intent to create an optimized monoamine oxidase-B (MAO-B) inhibitor, researchers in this investigation synthesized derivatives of the benzylidene oxindole scaffold in order to determine a lead molecule for further drug development. Previous work in this laboratory group evaluated a similar scaffold, the chalcone structural unit. As this class of compounds was determined to possess the ability to permeate the blood brain barrier (BBB) and to act as potent MAO-B inhibitors, it was posited that scaffold hopping from this previously studied molecular skeleton to benzylidene oxindoles would provide analogous results. Benzylidene oxindoles are readily synthesized via the Claisen-Schmidt condensation …

Silk Hydrogels Incorporated With Melanin, Anne Lutz

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Melanin is a naturally produced pigment found within the human body. Melanin is known for its ability to protect against Ultra Violet light, but also its ability to allow for mechanical protection. Making melanin a good addition to biomedical devices such as hydrogels. Silk hydrogels are weak in their load bearing capabilities but are known for their biocompatibility, biodegradability, and porosity. This makes the silk hydrogel a good material to incorporate melanin into in order to improve the mechanical properties. For the silk solution to form a solid, there must be a presence of both a catalyst and an oxidizer …

The Effect Of Circadian Clock Modulation On Cisplatin Cytotoxicity, Nadeen Nibal Ahmad Anabtawi

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Cisplatin is a DNA damage-based chemotherapeutic drug widely used to treat various types of cancers; however, the treatment's toxicity restricts its efficiency. Studies have shown that the circadian rhythm controls the DNA damage response and affects the repair pathways of cisplatin-induced DNA damage. Circadian clock modulation, therefore, has been proposed to be a potential mechanism for enhancing cisplatin tolerability. Here we used clock-enhancing molecules to evaluate the effect of pharmacological clock modulation on cisplatin cytotoxicity. Using cultured human cell lines, cisplatin cytotoxicity was found to be attenuated following treatment with circadian-enhancing molecules KS15 and SR8278. Moreover, the protein and mRNA …

Unraveling The Etiologies Of Discrete Subaortic Stenosis: A Focus On Left Ventricular Outflow Tract Hemodynamics, Jason A. Shar

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Discrete subaortic stenosis (DSS) is an obstructive cardiac disease characterized by the formation of a thin fibromuscular ring of tissue in the left ventricular (LV) outflow tract (LVOT). Although its etiology is unknown, the association between DSS, pediatric age, and morphological LVOT abnormalities points to a potential hemodynamic etiology. Here, altered subaortic flow dynamics, stemming from deviated LVOT anatomy, may promote lesion formation through local fluid shear stress abnormalities triggering membrane formation. The assessment of this hypothetical pathway requires elucidation of the complex LV wall shear stress (WSS) environment. The central hypothesis of this dissertation is that altered LV hemodynamics, …

Numerical Investigation Of Flow Around A Deformed Vacuum Lighter-Than-Air Vehicle, Jared N. Kerestes

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This study characterizes the functional dependence of drag on Reynolds number for a deformed vacuum lighter-than-air vehicle. The commercial computational fluid dynamics (CFD) code, FLUENT, is used to preform large eddy simulations (LES) over a range of Reynolds numbers; only Reynolds numbers less than 310,000 are considered. While the overarching goal is drag characterization, general flow-field physics are also discussed, including basic turbulence spectra. All large eddy simulations are preceded by a Reynolds-averaged Navier-Stokes (RANS) simulation using Menter’s shear stress transport (SST) model. The precursor RANS simulation serves to (1) provide realistic initial conditions, (2) decrease the time needed to …

China’S Legal Environment For Domestic Ngos: Standardized Policies For Greater Party-State Control Over Civil Society, Kelly E. Tursic

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This thesis examines one angle of state-society relations in authoritarian states through the lens of Chinese nongovernmental organizations (NGOs) and their legal environment. While grassroots organizations have not prompted political liberalization in China, they have not been entirely co-opted by the party-state either. Through an examination of policy changes, a study of 120 organizations, and a case study of a non-profit incubator, this thesis explores whether the political environment for China’s domestic NGOs varies by geographic region and issue area. The findings suggest there is not significant variation as the party-state has implemented standardized policies for increased control over civil …

Diversity And Function Of Algal Biofilms In The Laurentian Great Lakes, Leon R. Katona

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Attached algae are ubiquitous components of lake benthic habitats wherever sufficient light reaches submerged surfaces. Attached algae interact with heterotrophic bacteria and fungi to form complex biofilms (“periphyton”) that provide a nutritious food source for consumers and influence biogeochemical cycling by regulating redox potential at the sediment-water interface. Despite their ecological importance, there are limited data on the role of periphyton in the Laurentian Great Lakes. I quantified wave exposure and light availability in rocky nearshore habitats in Lake Erie and Lake Huron. Periphyton biomass and productivity in nearshore Lake Erie was very high while algal biomass and productivity in …

Functions Of Atr Kinase In Terminally Differentiated Human Epidermal Keratinocyles And In Human Ex-Vivo Skin After Exposure To Ultraviolet B Radiation, Vivek Shashank Nag Gogusetti

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The functions of Ataxia telangiectasia and Rad-3 related protein (ATR) is very much important in a cell, as it is a DNA damage response protein, which plays an important role in cell division, DNA repair and apoptosis. This protein helps in proliferation in the actively DNA dividing normal cells and in cancer cells. The functions of ATR in a proliferating cell are well studied and known to involve regulation of replication fork and cell cycle progression after DNA damage. Whereas, in a non-replicating cell, the functions of ATR are not so well known. In the human body, most of the …

Internal Loading Of Nitrogen (N) And Phosphorus (P), Reduced N Forms, And Periodic Mixing Support Cyanobacterial Harmful Algal Blooms (Habs) In Shallow, Eutrophic Honeoye Lake (New York, Usa), Justin Adam Myers

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Cyanobacteria are important primary producers, but large cyanobacterial harmful algal blooms (HABs) have many negative ecological and health impacts and are becoming increasingly common. Honeoye Lake (New York, USA) is a shallow, eutrophic lake characterized by increasingly frequent HABs. Nitrogen (N) and phosphorus (P) loads often drive HABs in lakes, and sediment processes can contribute to N removal (e.g., denitrification) or loading (e.g., N fixation, remineralization). Sediment cores and lake water were collected during May–October (2016–2018) at two sites and incubated with no amendments (controls) or 15N stable isotopes to measure sediment nutrient fluxes and N cycling dynamics in Honeoye …