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2021

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Articles 29551 - 29580 of 33735

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Blue Communities In Southeast Asia, V Cheung, A Bell, L Creencia, Le Fleming, Hc Goh, C Maharja, K Morrissey, I Richter, Ay-H Then, Mc Austen Jan 2021

Blue Communities In Southeast Asia, V Cheung, A Bell, L Creencia, Le Fleming, Hc Goh, C Maharja, K Morrissey, I Richter, Ay-H Then, Mc Austen

School of Biological and Marine Sciences

MARINE ECOSYSTEM SERVICES The global ocean and its marine resources play an important role in the livelihoods, food and general wellbeing of humanity. This is especially relevant to the coastal communities in Southeast Asia where almost all the countries have extensive coastlines and a long and rich history of marine-related activities that are key contributors to their economies, social structures and human health. The Southeast Asian seas link the Pacific and Indian Oceans and are characterised by high diversity habitats including coral reefs, mangroves and seagrass meadows, favoured by the tropical climate and heavy precipitation that transports nutrients to the …

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Reconstructing Baselines: Use Of Habitat Suitability Modelling To Predict Pre-Fishing Condition Of A Vulnerable Marine Ecosystem, Anna Leena Downie, Nils Piechaud, Kerry Howell, Froján C Barrio, Mar Sacau, Andrew Kenny Jan 2021

Reconstructing Baselines: Use Of Habitat Suitability Modelling To Predict Pre-Fishing Condition Of A Vulnerable Marine Ecosystem, Anna Leena Downie, Nils Piechaud, Kerry Howell, Froján C Barrio, Mar Sacau, Andrew Kenny

School of Biological and Marine Sciences

As industrialized fishing activities have moved into deeper water, the recognition of Vulnerable Marine Ecosystems (VMEs) has become important for the protection of the deep-sea. Our limited knowledge on the past and present distribution of VMEs hinders our ability to manage bottom fisheries effectively. This study investigated whether accounting for bottom fishing intensity (derived from Vessel Monitoring System records) as a predictor in habitat suitability models can (1) improve predictions of, and (2) provide estimates for a pre-fishing baseline for the distribution and biomass of a VME indicator taxon. Random Forest models were applied to presence/absence and biomass of Geodia …

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Talin Mechanosensitivity Is Modulated By A Direct Interaction With Cyclin-Dependent Kinase-1, Rosemarie E. Gough, Matthew C. Jones, Thomas Zacharchenko, Shimin Le, Miao Yu, Guillaume Jacquemet, Ste P. Muench, Jie Yan, Jd Humphries, Claus Jørgensen, Mj Humphries, Benjamin T. Goult Jan 2021

Talin Mechanosensitivity Is Modulated By A Direct Interaction With Cyclin-Dependent Kinase-1, Rosemarie E. Gough, Matthew C. Jones, Thomas Zacharchenko, Shimin Le, Miao Yu, Guillaume Jacquemet, Ste P. Muench, Jie Yan, Jd Humphries, Claus Jørgensen, Mj Humphries, Benjamin T. Goult

Peninsula Medical School

Talin (TLN1) is a mechanosensitive component of adhesion complexes that directly couples integrins to the actin cytoskeleton. In response to force, talin undergoes switch-like behavior of its multiple rod domains that modulate interactions with its binding partners. Cyclin-dependent kinase-1 (CDK1) is a key regulator of the cell cycle, exerting its effects through synchronized phosphorylation of a large number of protein targets. CDK1 activity maintains adhesion during interphase, and its inhibition is a prerequisite for the tightly choreographed changes in cell shape and adhesion that are required for successful mitosis. Using a combination of biochemical, structural, and cell biological approaches, we …

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Effects Of Perioperative Oxygen Concentration On Oxidative Stress In Adult Surgical Patients: A Systematic Review, Alexander H. Oldman, Daniel S. Martin, Martin Feelisch, Michael P.W. Grocott, Andrew F. Cumpstey Jan 2021

Effects Of Perioperative Oxygen Concentration On Oxidative Stress In Adult Surgical Patients: A Systematic Review, Alexander H. Oldman, Daniel S. Martin, Martin Feelisch, Michael P.W. Grocott, Andrew F. Cumpstey

Peninsula Medical School

No abstract provided.

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On The Relation Between Robustness, Evolvability And Phenotypic Complexity: Insight From Artificial Evolutionary Experiments, Nicola Milano Jan 2021

On The Relation Between Robustness, Evolvability And Phenotypic Complexity: Insight From Artificial Evolutionary Experiments, Nicola Milano

School of Engineering, Computing and Mathematics Theses

This thesis addresses the study of evolutionary methods to achieve robustness and evolvability in artificial systems. Chapter 1 introduces the research area, reviews the state of the art, discusses promising research directions, and presents the two major scientific objectives of the thesis. The first objective, which is covered in Chapter 2, is to verify and exploit the impact of the environmental variations on the evolvability of an artificial system. This is accomplished through the use of two experimental setup: the simulation of digital circuits and the simulation of a robotic agent situated in an external environment. Digital circuits are used …

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Emotional Body Language Synthesis For Humanoid Robots, Asimina Marmpena Jan 2021

Emotional Body Language Synthesis For Humanoid Robots, Asimina Marmpena

School of Engineering, Computing and Mathematics Theses

In the next decade, societies will witness a rise in service robots deployed in social environments, such as schools, homes, or shops, where they will operate as assistants, public relation agents, or companions. People are expected to willingly engage and collaborate with these robots to accomplish positive outcomes. To facilitate collaboration, robots need to comply with the behavioural and social norms used by humans in their daily interactions. One such behavioural norm is the expression of emotion through body language. Previous work on emotional body language synthesis for humanoid robots has been mainly focused on hand-coded design methods, often employing …

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Dc And Impedance Sensors Based On Graphene For The Early Detection Of Alzheimer’S Protein Biomarkers, Carrie Jean Haslam Jan 2021

Dc And Impedance Sensors Based On Graphene For The Early Detection Of Alzheimer’S Protein Biomarkers, Carrie Jean Haslam

School of Engineering, Computing and Mathematics Theses

Alzheimer’s disease (AD) is an irreversible neurodegenerative disorder, responsible for 60-70% of all dementia incidences. Estimates suggest that there are over 47 million people affected by dementia, of which ~65% suffer from AD worldwide, costing the global healthcare system ~$1 trillion annually or over 1% of global GDP. As such, the prevention and management of AD has now become a public health priority. Here five distinctively different biosensing models are reported, explicitly developed for the ultrasensitive and label-free detection of selective biomarkers associated with AD, as well as cancer, using impedance/admittance spectroscopy. The approach based on 4-probe (using direct current …

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Mild Cognitive Impairment: The Manchester Consensus, Ra Dunne, D Aarsland, Jt O’Brien, Et Al Jan 2021

Mild Cognitive Impairment: The Manchester Consensus, Ra Dunne, D Aarsland, Jt O’Brien, Et Al

Peninsula Medical School

Given considerable variation in diagnostic and therapeutic practice, there is a need for national guidance on the use of neuroimaging, fluid biomarkers, cognitive testing, follow-up and diagnostic terminology in mild cognitive impairment (MCI). MCI is a heterogenous clinical syndrome reflecting a change in cognitive function and deficits on neuropsychological testing but relatively intact activities of daily living. MCI is a risk state for further cognitive and functional decline with 5–15% of people developing dementia per year. However, ~50% remain stable at 5 years and in a minority, symptoms resolve over time. There is considerable debate about whether MCI is a …

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Trait Evaluations Of Faces And Voices: Comparing Within- And Between-Person Variability, Nadine Lavan, Mila Mileva, Andrew W. Young, A. Mike Burton, Carolyn Mcgettigan Jan 2021

Trait Evaluations Of Faces And Voices: Comparing Within- And Between-Person Variability, Nadine Lavan, Mila Mileva, Andrew W. Young, A. Mike Burton, Carolyn Mcgettigan

School of Psychology

Human faces and voices are rich sources of information that can vary in many different ways. Most of the literature on face/voice perception has focused on understanding how people look and sound different to each other (between-person variability). However, recent studies highlight the ways in which the same person can look and sound different on different occasions (within-person variability). Across three experiments, we examined how within- and between-person variability relate to one another for social trait impressions by collecting trait ratings attributed to multiple face images and voice recordings of the same people. We find that within-person variability in social …

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Journal Of Ecology 2021 Global Rainfall-Seagrass Resilience-Swan River, Chanelle L. Webster, Kathryn M. Mcmahon, Paul S. Lavery, Simone Strydom, Marta Sánchez Alarcón, Kieryn L. Kilminster, Katherine Bennet, Sian Mcnamara Jan 2021

Journal Of Ecology 2021 Global Rainfall-Seagrass Resilience-Swan River, Chanelle L. Webster, Kathryn M. Mcmahon, Paul S. Lavery, Simone Strydom, Marta Sánchez Alarcón, Kieryn L. Kilminster, Katherine Bennet, Sian Mcnamara

Research Datasets

The excel file contains: summary of daily maximum precipitation from global rainfall analysis, monthly change in seagrass indicators (biomass, leaf density etc); water quality data including salinity, temperature and light data. There are also .nc files containing precipitation data from 1979-2019.

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Supplementary Table 11: Regional Zotu Table (Data As Relative Abundances), Charlie M. Phelps, Kathryn Mcmahon, Andrew Bissett, Rachele Bernasconi, Peter D. Steinberg, Torsten Thomas, Ezequiel M. Marzinelli, Megan J. Huggett Jan 2021

Supplementary Table 11: Regional Zotu Table (Data As Relative Abundances), Charlie M. Phelps, Kathryn Mcmahon, Andrew Bissett, Rachele Bernasconi, Peter D. Steinberg, Torsten Thomas, Ezequiel M. Marzinelli, Megan J. Huggett

Research Datasets

This zOTU table is the relative abundances for the whole regional (combined WA and NSW) dataset.

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Breeding And Feeding Habitat Selection By An Island Endemic Bird May Increase Its Vulnerability To Climate Change, Paul Radley, Eddie Van Etten, David Blake, Robert Davis Jan 2021

Breeding And Feeding Habitat Selection By An Island Endemic Bird May Increase Its Vulnerability To Climate Change, Paul Radley, Eddie Van Etten, David Blake, Robert Davis

Research Datasets

Characterising patterns of habitat use is an important first step for effective conservation planning. Species restricted to low-lying islands are at greatest risk from climate change-related sea level rise, and requirements for breeding and foraging habitat may determine their risk from tidal inundation. The endangered Micronesian Scrubfowl (Megapodius laperouse senex) is a model species for understanding these impacts. This species faces the cumulative challenges of tourist visitation, invasive species, and rising sea levels, yet little is understood about its habitat use in the Rock Islands Southern Lagoon Conservation Area (RISL) of Palau. We studied the habitat requirements of …

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Children And Crime: In The Moment, K Haines, S Case, R Smith, Laidler K Joe, N Hughes, C Webster, T Goddard, J Deakin, D Johns, K Richards, P Gray Jan 2021

Children And Crime: In The Moment, K Haines, S Case, R Smith, Laidler K Joe, N Hughes, C Webster, T Goddard, J Deakin, D Johns, K Richards, P Gray

School of Law, Humanities and Social Sciences

Traditional approaches to understanding and responding to children and crime are fundamentally based on ‘miniaturised’ adult models. The assumption appears to be that children are adults in the making, essentially just smaller, developing versions of grown-ups. This view of children is increasingly being challenged. Children are not simply putative adults, they are different, distinct and developing. This article sets out to explore the notion that children essentially think and behave ‘in the moment’. The implications of this for our understanding of children and crime are also explored.

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Joint Modeling Of Rnaseq And Radiomics Data For Glioma Molecular Characterization And Prediction, Zeina A. Shboul, Norou Diawara, Arastoo Vossough, James Y. Chen, Khan M. Iftekharuddin Jan 2021

Joint Modeling Of Rnaseq And Radiomics Data For Glioma Molecular Characterization And Prediction, Zeina A. Shboul, Norou Diawara, Arastoo Vossough, James Y. Chen, Khan M. Iftekharuddin

Electrical & Computer Engineering Faculty Publications

RNA sequencing (RNAseq) is a recent technology that profiles gene expression by measuring the relative frequency of the RNAseq reads. RNAseq read counts data is increasingly used in oncologic care and while radiology features (radiomics) have also been gaining utility in radiology practice such as disease diagnosis, monitoring, and treatment planning. However, contemporary literature lacks appropriate RNA-radiomics (henceforth, radiogenomics) joint modeling where RNAseq distribution is adaptive and also preserves the nature of RNAseq read counts data for glioma grading and prediction. The Negative Binomial (NB) distribution may be useful to model RNAseq read counts data that addresses potential shortcomings. …

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Introduction: What Matters For Black Workers After 2020?, Michael Z. Green Jan 2021

Introduction: What Matters For Black Workers After 2020?, Michael Z. Green

Faculty Scholarship

This paper operates as the Introduction to a Symposium that resulted from a Call for Papers discussing the topic of "What Matters for Black Workers after 2020?" to be published in the 25th volume of the Employee Rights and Employment Policy Journal for 2021. This paper briefly discusses the papers in that Symposium publication authored by Jamillah Bowman Williams, Michael Duff, and Henry Chambers that address this topic. I thank Noah Zatz, Marty Malin, Michael Oswalt, Marcia McCormick, and Tristan Kirvan for their dedicated efforts, feedback, and encouragement in completing this Symposium issue for the journal on this very important …

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Traditional And Modern Breeding Strategies Towards Developing Resilient Crops: Two Case Studies In Tomato, Estefania Tavares Flores Jan 2021

Traditional And Modern Breeding Strategies Towards Developing Resilient Crops: Two Case Studies In Tomato, Estefania Tavares Flores

Graduate Theses, Dissertations, and Problem Reports (ETD)

Crop designing for resilience traits to produce satisfactorily under adverse conditions and scenarios is a priority for the future of global food security. In this thesis, two different approaches addressing major stress factors for tomato cropping are presented. We first aimed to domesticate tomato de novo as a high-salinity resistant crop using the wild relative, S. cheesmaniae via gene editing. We conducted single-gene and multiplex knock-out strategies using CRISPR/Cas9 genome editing to create loss-of-function alleles for the domestication-related genes BIF, CycB, J2, EJ2, MULTI, SP, SP5G, and FW11.3 in order to create a novel, halophyte tomato harboring an inherent high-salinity …

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Biocompatible And Multifunctional Trityl Spin Probes For Electron Paramagnetic Resonance Spectroscopy, Teresa D. Gluth Jan 2021

Biocompatible And Multifunctional Trityl Spin Probes For Electron Paramagnetic Resonance Spectroscopy, Teresa D. Gluth

Graduate Theses, Dissertations, and Problem Reports (ETD)

The primary objective of my thesis was to develop and utilize a biocompatible multifunctional trityl spin probe for concurrent measurement of pO2, pHe, and [Pi] in vivo by electron paramagnetic resonance (EPR) spectroscopy (Chapter 2). My first goal was to synthesize the proposed probe we are terming HOPE71. Secondly, HOPE71 was characterized by X-band and L-band EPR spectroscopy. Next, the biocompatibility of HOPE71 was assessed through an albumin binding test, cytotoxicity assays, and in vivo intravenous tolerance. Then, the use of HOPE71 to measure the target parameters was demonstrated in a breast cancer …

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Identifying Self-Determined Learning Practices Within Social Media For Teacher Professional Development, Leah Mcjilton Jan 2021

Identifying Self-Determined Learning Practices Within Social Media For Teacher Professional Development, Leah Mcjilton

Graduate Theses, Dissertations, and Problem Reports (ETD)

The collective increase of learner-centered teaching and substantial technology use in the classroom has given instructors potential opportunities to support students in developing lifelong learning skills. The ability to manage one’s own learning is an essential skill for lifelong learners in today’s workforce. Heutagogy, or self-determined learning, suggests that individuals have agency with respect to how, what, and when they learn. Heutagogy provides a framework for making the most of these developments, drawing on established learner-centered education theories. The key principles of heutagogy provide a foundation for designing and developing learning environments using social media. In order for teachers to …

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A Short Film That Addresses Substance Use Disorders In Rural Communities And Strategies In Prevention And Treatment Of Addiction, Sarah R. Poteracki Jan 2021

A Short Film That Addresses Substance Use Disorders In Rural Communities And Strategies In Prevention And Treatment Of Addiction, Sarah R. Poteracki

Graduate Theses, Dissertations, and Problem Reports (ETD)

This research paper and accompanying video (link to the short film is here: https://drive.google.com/drive/folders/1etDnUmEvkOds8J0EKnq1gnFO79-GggjY) offer insight into the current state of research collaboration surrounding substance use disorders in West Virginia. This professional project explores the importance of collaboration both in a research and clinical setting and in the social realm. The film was shown at the 2nd annual meeting for the Appalachian Node of the National Institute on Drug Abuse Clinical Trials Network on February 25, 2021. I interviewed 14 researchers and experts from a diverse range of disciplines who shared insights and strategies in the prevention and treatment of …

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Simulating Municipal Cybersecurity Incidents: Recommendations From Expert Interviews, Kira Gedris, Kayla Bowman, Aatish Neupane, Amanda Lee Hughes, Elizabeth Bonsignore, Ryan W. West, Jon Balzotti, Derek L. Hansen Jan 2021

Simulating Municipal Cybersecurity Incidents: Recommendations From Expert Interviews, Kira Gedris, Kayla Bowman, Aatish Neupane, Amanda Lee Hughes, Elizabeth Bonsignore, Ryan W. West, Jon Balzotti, Derek L. Hansen

Faculty Publications

As cyberattacks on city and public infrastructures become increasingly common and harmful, it is critical that we train the professional workforce to prepare and respond appropriately. This paper supports the development of educational simulations and related experiential learning exercises that help prepare city and public infrastructure personnel to effectively respond to cybersecurity attacks. Specifically, it synthesizes the findings from 8 expert interviews including 12 cybersecurity experts from federal, state, city organizations, as well as academics with relevant expertise. We organize the findings into key learning outcomes, scenarios, roles, and issues that simulation designers should consider. The result paints a vivid …

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2021 Spring Commencement, Georgia Southern University Jan 2021

2021 Spring Commencement, Georgia Southern University

Commencement Programs

No abstract provided.

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2021 Fall Commencement, Georgia Southern University Jan 2021

2021 Fall Commencement, Georgia Southern University

Commencement Programs

No abstract provided.

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Extending Animal Welfare Science To Include Wild Animals, Walter Veit, Heather Browning Jan 2021

Extending Animal Welfare Science To Include Wild Animals, Walter Veit, Heather Browning

Animal Sentience

Ng’s (2016) target article built on his earlier work advocating a science of welfare biology (Ng 1995). Although there were problems with the models proposed in Ng’s original paper regarding the balance of pleasure and suffering for wild animals, his call for a science of wild animal welfare was a sound one. This does not require a new discipline but just an extension of the existing frameworks and methods of animal welfare science to include wild animals.

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Contact, Moral Foundations Or Knowledge? What Predicts Attitudes Towards Women Who Undergo Ivf, Alicja Malina, Marta Roczniewska, Julie Ann Pooley Jan 2021

Contact, Moral Foundations Or Knowledge? What Predicts Attitudes Towards Women Who Undergo Ivf, Alicja Malina, Marta Roczniewska, Julie Ann Pooley

Research outputs 2014 to 2021

Background: The willingness to try in vitro fertilization (IVF) as an infertility treatment, as well as its psychosocial consequences for couples, may be influenced by how they perceive the attitudes of general public towards this procedure. The focus of the current study was to identify predictors of attitudes towards mothers who underwent IVF to conceive a child. Three predictors were derived from attitude components: contact with someone who had undergone IVF (behavior), moral foundations (emotions), and the level of knowledge (cognition) about IVF. Method: In total, 817 participants (118 male and 692 female, 7 unreported) from Poland took part in …

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Spon1 Is Associated With Amyloid-Β And Apoe Ε4-Related Cognitive Decline In Cognitively Normal Adults, Shane Fernandez, Samantha C. Burnham, Lidija Milicic, Greg Savage, Paul Maruff, Madeline Peretti, Hamid R. Sohrabi, Yen Ying Lim, Michael Weinborn, David Ames, Colin L. Masters, Ralph N. Martins, Stephanie Rainey-Smith, Christopher C. Rowe, Olivier Salvado, David Groth, Giuseppe Verdile, Victor L. Villemagne, Tenielle Porter, Simon M. Laws Jan 2021

Spon1 Is Associated With Amyloid-Β And Apoe Ε4-Related Cognitive Decline In Cognitively Normal Adults, Shane Fernandez, Samantha C. Burnham, Lidija Milicic, Greg Savage, Paul Maruff, Madeline Peretti, Hamid R. Sohrabi, Yen Ying Lim, Michael Weinborn, David Ames, Colin L. Masters, Ralph N. Martins, Stephanie Rainey-Smith, Christopher C. Rowe, Olivier Salvado, David Groth, Giuseppe Verdile, Victor L. Villemagne, Tenielle Porter, Simon M. Laws

Research outputs 2014 to 2021

Background: Genetic variation in Spondin-1, specifically rs11023139, has been associated with reduced rates of cognitive decline in individuals with Alzheimer's disease. Objective: The aim of this study was to assess whether the association was present in cognitively normal older adults. Methods: Longitudinal cognitive decline was investigated using linear mixed modelling in a cohort of 590 cognitively normal older adults enrolled in the Australian Imaging, Biomarkers and Lifestyle Study. Results: No independent effect of Spondin-1 rs11023139 on cognitive decline was observed. However, significant associations were observed for the interaction between Apolipoprotein E (APOE) ϵ4 and rs11023139 in individuals with high amyloid-β …

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A Population-Specific Major Allele Reference Genome From The United Arab Emirates Population, Gihan Daw Elbait, Andreas Henschel, Guan K. Tay, Habiba S. Al Safar Jan 2021

A Population-Specific Major Allele Reference Genome From The United Arab Emirates Population, Gihan Daw Elbait, Andreas Henschel, Guan K. Tay, Habiba S. Al Safar

Research outputs 2014 to 2021

The ethnic composition of the population of a country contributes to the uniqueness of each national DNA sequencing project and, ideally, individual reference genomes are required to reduce the confounding nature of ethnic bias. This work represents a representative Whole Genome Sequencing effort of an understudied population. Specifically, high coverage consensus sequences from 120 whole genomes and 33 whole exomes were used to construct the first ever population specific major allele reference genome for the United Arab Emirates (UAE). When this was applied and compared to the archetype hg19 reference, assembly of local Emirati genomes was reduced by ∼19% (i.e., …

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Viral-Mediated Microbe Mortality Modulated By Ocean Acidification And Eutrophication: Consequences For The Carbon Fluxes Through The Microbial Food Web, Andrea Malits, Julia A. Boras, Vanessa Balagué, Eva Calvo, Josep M. Gasol, Cèlia Marrasé, Carles Pelejero, Jarone Pinhassi, Maria Montserrat Sala, Dolors Vaqué Jan 2021

Viral-Mediated Microbe Mortality Modulated By Ocean Acidification And Eutrophication: Consequences For The Carbon Fluxes Through The Microbial Food Web, Andrea Malits, Julia A. Boras, Vanessa Balagué, Eva Calvo, Josep M. Gasol, Cèlia Marrasé, Carles Pelejero, Jarone Pinhassi, Maria Montserrat Sala, Dolors Vaqué

Research outputs 2014 to 2021

Anthropogenic carbon emissions are causing changes in seawater carbonate chemistry including a decline in the pH of the oceans. While its aftermath for calcifying microbes has been widely studied, the effect of ocean acidification (OA) on marine viruses and their microbial hosts is controversial, and even more in combination with another anthropogenic stressor, i.e., human-induced nutrient loads. In this study, two mesocosm acidification experiments with Mediterranean waters from different seasons revealed distinct effects of OA on viruses and viral-mediated prokaryotic mortality depending on the trophic state and the successional stage of the plankton community. In the winter bloom situation, low …

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Covid-19 Disease Severity And Death In Relation To Vitamin D Status Among Sars-Cov-2-Positive Uae Residents, Habiba Alsafar, William B. Grant, Rafiq Hijazi, Maimunah Uddin, Nawal Alkaabi, Guan Tay, Bassam Mahboub, Fatme Al Anouti Jan 2021

Covid-19 Disease Severity And Death In Relation To Vitamin D Status Among Sars-Cov-2-Positive Uae Residents, Habiba Alsafar, William B. Grant, Rafiq Hijazi, Maimunah Uddin, Nawal Alkaabi, Guan Tay, Bassam Mahboub, Fatme Al Anouti

Research outputs 2014 to 2021

Insufficient blood levels of the neurohormone vitamin D are associated with increased risk of COVID-19 severity and mortality. Despite the global rollout of vaccinations and promising preliminary results, the focus remains on additional preventive measures to manage COVID-19. Results conflict on vitamin D’s plausible role in preventing and treating COVID-19. We examined the relation between vitamin D status and COVID-19 severity and mortality among the multiethnic population of the United Arab Emirates. Our observational study used data for 522 participants who tested positive for SARS-CoV-2 at one of the main hospitals in Abu Dhabi and Dubai. Only 464 of those …

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Accounting For The Influence Of Temperature And Location When Predicting Seagrass (Halophila Ovalis) Photosynthetic Performance, Nicole E. Said, Kathryn Mcmahon, Paul Lavery Jan 2021

Accounting For The Influence Of Temperature And Location When Predicting Seagrass (Halophila Ovalis) Photosynthetic Performance, Nicole E. Said, Kathryn Mcmahon, Paul Lavery

Research outputs 2014 to 2021

We show that the effect of temperature on photosynthesis of a widely distributed and ecological important seagrass species was not consistent among locations, with some evidence of acclimation to the local temperature range. This has important implications for modelling seagrass productivity and the impacts of light reduction on seagrass ecosystems. Reduced light availability is one of the main pressures negatively impacting on seagrass meadows worldwide. Our knowledge of seagrass photosynthetic characteristics is critical to predicting and managing impacts of light reducing activities but suffers from two critical information gaps: first, data is overwhelmingly derived from studies of leaf tissue and …

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Cdk5 Positively Regulates Notch1 Signaling In Pancreatic Cancer Cells By Phosphorylation, Qiaoyun Chu, Liyong Wang, Jie Zhang, Wei Wang, Youxin Wang Jan 2021

Cdk5 Positively Regulates Notch1 Signaling In Pancreatic Cancer Cells By Phosphorylation, Qiaoyun Chu, Liyong Wang, Jie Zhang, Wei Wang, Youxin Wang

Research outputs 2014 to 2021

The marked overexpression of cyclin-dependent kinase 5 (CDK5) or Notch1 receptor, which plays critical roles in pancreatic ductal adenocarcinoma (PDAC) development, has been detected in numerous PDAC cell lines and tissues. Although, a previous study has demonstrated that CDK5 inhibition disrupts Notch1 functions in human umbilical vein endothelial cells, the mechanism underlying Notch1 activation regulated by CDK5 remains unclear. Herein, we identified a physical interaction between CDK5 and Notch1 in PDAC cells, with the Notch1 peptide phosphorylated by CDK5/p25 kinase. CDK5 blockade resulted in the profound inhibition of Notch signaling. Accordingly, CDK5 inhibition sensitized PDAC cell proliferation and migration following …

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