Digital Commons Network^™

The Loss Of Opa1 Accelerates Intervertebral Disc Degeneration And Osteoarthritis In Aged Mice, Vedavathi Madhu, Miriam Hernandaz-Meadows, Ashley Coleman, Kimheak Sao, Kameron Inguito, Owen Haslam, Paige Boneski, Hiromi Sesaki, Ruteja Barve, John Collins, Makarand Risbud

Department of Orthopaedic Surgery Faculty Papers

Recent studies have highlighted the importance of mitochondria in NP cells and articular chondrocyte health. Since the understanding of mechanisms governing mitochondrial dynamics in these tissues is lacking, we investigated the role of OPA1, a mitochondrial fusion protein, in their homeostasis. OPA1 knockdown in NP cells altered mitochondrial size and cristae shape and increased the oxygen consumption rate. OPA1 governed the morphology of multiple organelles, including peroxisomes, early endosomes and cis-Golgi and loss resulted in the dysregulation of autophagy. Metabolic profiling and

Artificial Intelligence And Humanoid Robotics: Bioethical Implications Of Replacing Human Agency In Healthcare And Beyond, Sara Feizyab, Gabriele Bonetti, Maria Chiara Medori, Cecilia Micheletti, Immacolata De Luca, Kevin Donato, Jan Miertuš, Mehmet Sait Dundar, Miroslava Vráblová, Gary Henehan, Richard Brown, Robert Marks, Stanislav Miertus, Lorenzo Lorusso, Gianluca Martino Tartaglia, Munis Dundar, Sandro Michelini, Stephen Thaddeus Connelly, Ariola Bacu, Tommaso Beccari, Ornela Gordani, Xhilda Dhamo, Eglantina Kalluci, Dominika Vešelényiová, Iveta Dirgová Luptáková, Jiri Pospíchal, Matteo Bertelli

Research Outputs: 2025-Present

The integration of advanced artificial intelligence (AI) and humanoid robotics into healthcare represents a critical evolution in biotechnology with profound societal implications. This review explores the bioethical implications of these technologies, and their potential to displace human agency in life-critical decisions. It adopts an interdisciplinary approach encompassing ethics, law, and technology. The review examines how innovations in AI and robotics might shift autonomy from humans to machines, and addresses the accountability challenges inherent in such transitions. We synthesize discussions on the ethical management of AI and robotics, underscoring the importance of maintaining human oversight and integrating ethical standards in technology …

Teratogenic Effects Of Serotonin Receptor 2b Disruption On The Migration And Cardiac Derivatives Of The Cardiac Neural Crest, Brian K. Wells, Gwyneth K. Garramone, Amira Mahomed, Max Ezin

Biology Faculty Works

Background: Cardiac neural crest cells (cNCCs) are critical for heart development, and their disruption can result in congenital heart defects. Serotonin (5-HT) signaling, specifically via 5-HT2B and 5-HT2C receptors, regulates diverse physiological processes, including neural crest migration. This study investigates how modulation of 5-HT2B and 5-HT2C receptor activity impacts cNCC migration and the development of their derivatives, with relevance to serotonergic drug safety during pregnancy.

Methods

Chicken embryos at HH8 were treated with 50 μL of 20 μM 1-Methylpsilocin (1-MP), an inverse agonist of 5-HT2B and agonist of 5-HT2C, and collected at HH14 to assess cNCC migration. Embryos were pre-treated …

High Frequency Factor Analysis With Partially Observable Factors, Dachuan Chen, Wenqi Lu, Siyu Xie

Research Collection School Of Economics

This paper considers a novel factor structure – Partially Observable Factor Model – where both observable factors and latent factors exist in the model simultaneously. Such factor structure can make sure both interpretability and goodness-of-fit at the same time. Necessary estimation methodologies for this partially observable factor model are developed in this paper for the high frequency data. The proposed estimation methodology is robust to jumps, microstructure noise and asynchronous observation times simultaneously.When the observable factors are exogenous, we provide the estimation theory for the integrated eigenvalues of the residual covariance matrix, which including the bias-corrected estimator, central limit theorem …

Reaction Control Mechanism In Deoxyuridine 5'-Triphosphate Nucleotidohydrolase, Aaron Delay

School of Biological Sciences: Dissertations, Theses, and Student Research

Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) is an enzyme involved in the pyrimidine biosynthesis pathway, a key component of cellular DNA metabolism. It regulates intracellular uracil carrying triphosphate levels by hydrolyzing dUTP, thereby providing a substrate for thymidylate synthase (TS). The effective inhibition of dUTPase is expected to enhance TS-targeted chemotherapy by promoting thymine-less apoptosis.

Although the reaction mechanism of dUTPase has been studied, the human nuclear homotrimeric form remains complex, as all three subunits cooperatively form a single active site. As a result, the detailed molecular dynamics of its catalysis are still not fully understood. In this study, I investigated the …

The Effects Of Surface Irregularity And Sex On Spatiotemporal Parameters, Brooke L. Brody, Thomas A. Wenzel, Iona Halliday, Tyler N. Brown

Idaho Conference on Undergraduate Research

Females are more susceptible to tibial stress fractures than males. A sex dimorphism in gait spatiotemporal parameters like changes in cadence, stride length, and stride width during running may increase tibial bone load and females’ injury risk. However, it is currently unclear if running over uneven surfaces impacts gait spatiotemporal parameters and exacerbates a hazardous dimorphism in female gait parameters. Twenty four healthy runners (12 male, 12 female) had gait spatiotemporal parameters quantified when running at 4.5 m/s for flat and uneven surfaces. During trial, cadence, stride length, and stride width were quantified and submitted to analysis. We anticipate females …

Enzyme-Independent Functions Of Hdac3 In The Adult Hear, Sichong Qian, Chen Zhang, Wenbo Li, Shiyang Song, Guanqiao Lin, Zixiu Cheng, Wenjun Zhou, Huiqi Yin, Yueli Wang, Haiyang Li, Ying H Shen, Zheng Sun

Center on Aging Staff Publications

The cardioprotective effects of histone deacetylase (HDAC) inhibitors (HDIs) are at odds with the deleterious effects of HDAC depletion. Here, we use HDAC3 as a prototype HDAC to address this contradiction. We show that adult-onset cardiac-specific depletion of HDAC3 in mice causes cardiac hypertrophy and contractile dysfunction on a high-fat diet (HFD), excluding developmental disruption as a major reason for the contradiction. Genetically abolishing HDAC3 enzymatic activity without affecting its protein level does not cause cardiac dysfunction on HFD. HDAC3 depletion causes robust downregulation of lipid oxidation/bioenergetic genes and upregulation of antioxidant/anti-apoptotic genes. In contrast, HDAC3 enzyme activity abolishment causes …

Muscle Rev-Erb Controls Time-Dependent Adaptations To Chronic Exercise In Mice, Jidong Liu, Fang Xiao, Abhinav Choubey, Udhaya Kumar S, Yanxiang Wang, Sungguan Hong, Tingting Yang, Husniye Gul Otlu, Ege Sanem Oturmaz, Emanuele Loro, Yuxiang Sun, Pradip Saha, Tejvir S Khurana, Li Chen, Xinguo Hou, Zheng Sun

Center on Aging Staff Publications

The best time of the day for chronic exercise training and the mechanism underlying the timing effects is unclear. Here, we show that low-intensity, low-volume treadmill training in mice before sleep yields greater benefits than after waking for muscle contractile performance and systemic glucose tolerance. Baseline muscle performance also exhibits diurnal variations, with higher strength but lower endurance before sleep than after waking. Muscle-specific knockout of circadian clock genes Rev-erbα/β (Rev-MKO) in male mice eradicates the diurnal variations in both training and baseline conditions without affecting muscle mass, mitochondrial content, food intake, or spontaneous activities. Multi-omics and metabolic measurements reveal …

Still I Lie Here, Rachel A. Taylor

Digressions: Literary & Art Journal

Artist Statement

"This photo was captured in the forest of Providence, North Carolina, while spending time with nature. Staring into the water I felt a stillness; and peace rolled over me. Later on that same hike, I saw a sign that the trail I was standing on, was soon to be demolished. The forest would be turned into yet another roadway. That evening, I joined many other locals in a petition to stop the deforestation of Greenways in North Carolina.

I often think about that forest, and the peace I received that day. And even in the face of a …

Star Girl, Roseline Jean-Pierre

Digressions: Literary & Art Journal

Artist Statement

"The world is so vivid and bustling with art. I just hope to capture it all before my heart. I am just a photographer with a keen eye. I want to capture everything I see, art is all around me and it's hard not to notice so I flick a picture and hope that my work shows it."

Saccharine, Alessandra Alvarez Coke

Digressions: Literary & Art Journal

Author Statement

"This poem is about longing and yearning, specifically as a queer woman. In friendships between queer women, the lines between platonic and romantic partnership often get blurred and distorted. Specifically 'Saccharine' explores these complex feelings of guilt, loyalty, and love in an undefined relationship, where the affection is assumed to be unreciprocated."

Love Potions And Love Letters: An Argument That Libertarian Free Will Isn't Necessary For Loving God, Netanel Ron

Faith and Philosophy: Journal of the Society of Christian Philosophers

No abstract provided.

High-Impact Chronic Pain And Cognitive Decline Among Mexicans Aged 60 And Older From 2012 To 2018, Sadaf Arefi Milani, Sirena Gutierrez, Brandon O'Grady, Rebeca Wong, Rafael Samper-Ternent, Brian Downer

Faculty, Staff and Student Publications

Pain is associated with cognitive decline, but prior research has not considered differences between high- and low-impact chronic pain or low-and middle-income countries, such as Mexico. Our objective was to evaluate the association between high-impact chronic pain and cognitive decline among older adults in Mexico. We used data from the 2012-2018 Mexican Health and Aging Study (MHAS), a nationally representative study of older Mexican adults (60+). Pain, measured at each wave, was categorized as high-impact chronic pain (pain that limits daily activities), low-impact chronic pain (pain that did not limit daily activities), and no chronic pain. Cognition was measured at …

Diet, Gut Microbiota, And Histidine Metabolism Toward Imidazole Propionate Production In Relation To Type 2 Diabetes, Hongbo Yang, Kai Luo, Brandilyn A Peters, Yi Wang, Yanbo Zhang, Martha Daviglus, Amber Pirzada, Christina Cordero, Bing Yu, Robert D Burk, Robert Kaplan, Qibin Qi

Faculty, Staff and Student Publications

Objective: To examine associations of serum imidazole propionate (ImP), histidine, and their ratio with incident type 2 diabetes (T2D) and related dietary and gut microbial factors in U.S. Hispanic/Latino people.

Research design and methods: In the Hispanic Community Health Study/Study of Latinos, we evaluated serum ImP, histidine, and ImP-to-histidine ratio at baseline (2008-2011) and their cross-sectional associations with dietary intake and prospective associations with incident T2D over ∼12 years (n = 4,632). In a subsample with gut microbiota data during a follow-up visit (2016-2018), we examined gut microbial species associated with serum ImP and their potential interactions with dietary intake. …

Tissue Engineering: History, Principles, Applications, Challenges, And Future Work, Alexa Cesari, Ms

Student Papers, Posters & Projects

Tissue engineering is a comprehensive and cutting-edge field that leverages principles from multiple scientific disciplines to assist in regenerative medicine. It is defined by the most basic structure of the human body, the cell. When an injury occurs, cells send signals to initiate wound healing processes. In most cases, the body is equipped to heal wounds on its own; however, there are instances where wounds are too severe and cannot undergo proper regeneration. When this occurs, alternative measures are taken to assist in wound repair. With numerous advancements made over the years, tissue engineering has become an increasingly common method …

The Impact Of Teachers’ Cultural Competence On Curriculum Development In Advanced English Courses, Rhine D. Kirkland

Theses and Dissertations

As student demographics become increasingly more diverse, it is imperative that classroom teachers are responsive to the needs of learners from varied backgrounds. The purpose of this study was to examine the impact of teachers’ cultural competence on their curriculum development in advanced English courses. This case study provided insight on the use of administrative instructional coaching as a professional learning approach to aid in teachers’ creation and implementation of culturally responsive curriculums based on the tenets of Culturally Relevant Pedagogy. The analysis and triangulation of survey, interview, document, and observation data yielded key themes regarding the considerations and conditions …

Impact Of Simulation On Project Management Knowledge, Self-Efficacy, And Student Perceptions: An Action Research Study With Non-Traditional Undergraduate Students In A Project Management Capstone Course, Deborah Marindin

Theses and Dissertations

This study investigated the effectiveness of a project management simulation in enhancing non-traditional undergraduate students' project management knowledge, self-efficacy, and perceptions in a project management capstone course. The simulation tool, SimulTrain®, provided an authentic, real-world context to bridge the gap between theoretical knowledge and practical application. Utilizing mixed-methods action research, the study comprehensively evaluated the simulation’s impact on students’ learning. The research was guided by three questions: (1) How does a simulation activity affect non-traditional students’ project management knowledge in a capstone course? (2) To what extent does the simulation impact their self-efficacy? (3) What are students’ perceptions of learning …

Exploring Professional Development Of Expatriate Teachers In Kuwait Through Mentoring, Taji Abdul-Raheem

Theses and Dissertations

Professional growth as a teacher is fundamental for teacher retention and an overall determinant of favorable student outcomes. Academic research underscores professional development as an indicator of success for a school’s success as well. Expatriate teachers in Kuwait, who comprise a significant portion of the workforce, come from various backgrounds and levels of readiness for teaching in a contextually and culturally unfamiliar setting. Due to how teachers are hired and approved for teaching without induction, an implementation for continuous professional development has yet to be materialized for teachers in the private sector. This qualitative study leverages Improvement Science to diagnose …

Vitamin D Status And Risk For Breast Cancer In Kenya, Ronald Wasike, Victor Mobegi, Esther Maina, Francis Makokha, Robert Armstrong, Annastacia Mbithi

General Surgery, East Africa

Background: Vitamin D plays a critical role in bone metabolism, calcium regulation, and various cellular processes, including those linked to cancer. The biologically active form, 1,25-dihydroxyvitamin D [1,25(OH)2D], works through the Vitamin D Receptor (VDR). Polymorphisms in VDR and related genes have been associated with cancer risk, including breast cancer. This case-control study aimed to investigate the relationship between serum vitamin D levels and breast cancer among Kenyan women.

Methods: Serum 25-hydroxyvitamin D [25(OH)D] levels were measured in 112 breast cancer patients and 106 controls using electrochemiluminescence.

Results: Results indicated that 81.2% of participants had deficient or insufficient vitamin D …

Clinical Trials Unit Newsletter - Issue 02, Clinical Trials Unit (Ctu)

Clinical Trials Unit (CTU) Archives

• What's inside this issue:
• The Clinical Trials Summit of Pakistan 2025
• Biosimilar trials at CTU!
• Completion of the Panbio Self-Test Enrolment
• Coming Together for Better Cancer Care
• Informative Snippets
• Clinical Trials Unit celebrates Clinical Trials Day
• Happenings!
• Achievements
• Trials Recruiting Now
• Trials Completed
• Publications
• Upcoming Events

Institute For Global Health And Development : Issue 11 - July 2025, Institute For Global Health And Development

IGHD Newsletters Archives

• Climate Change, Water, And the Way Forward
• Dr. Zulfiqar Bhutta Joins Global Panel on CGTN America For World Health Day 2025
• IGHD Welcomes New Associate Faculty Members
• Dr. Zulfiqar A. Bhutta Named American Society For Nutrition (ASN) Distinguished Fellow 2025
• IGHD’s Dr. Ammad Qazi Delivers Keynote Address at AKU Climate Change Event
• New IGHD Research Project to Develop Sustainable Health Infrastructure in LMICS

CLIMATE CHANGE, WATER, AND THE WAY FORWARD

The Effect Of Integrating Augmented Reality (Ar) Technology In Science Education Teaching On Improving The Biological Concepts Learning Among Kindergarten Children, Kawthar Habeeb

Journal of Educational and Psychological Studies

This quasi-experimental study explored the impact of AR on acquiring biological concepts among kindergarteners. The sample comprised 30 second-level kindergarteners from a school in Farwaniya Educational Directorate, Kuwait. Participants were randomly divided into an experimental group (n = 15), taught using AR, and a control group (n = 15), taught traditionally. Results revealed statistically significant di erences in biological concept understanding, favoring the experimental group. Additionally, the experimental group demonstrated significant improvement from pre-test to post-test stages. These findings highlight the potential of AR to enhance learning outcomes in kindergarten biology education. The study emphasizes the importance of integrating AR …

Post-Anthropocene Provocations: Human-Sized Scholars’ Rocks, Cronenbergian Flesh Caves And Zen Garden Design Cues For A Future Proof Re(Image)Ining, Brenton Rossow, Darren Tynan

Research outputs 2022 to 2026

This research explores concertinaing past, present and future interventional creative and pedagogical practices to address the challenges of the Post-Anthropocene era. We argue that the Post-Anthropocene is marked by biotechnological entanglements, environmental violence and digital overstimulation. The discussions herein critique a hyperattentive achievement society characterised by a scattering of attention, a near-constant screen-mediated stream of digital material and tasks and the commodification of leisure time. Enlisting Byung-Chul Han’s concept of hyperattention and themes and motifs from David Cronenberg’s films, the authors propose “FUTURE PROOF re(image)ining” as a collaborative Cli-Fi narrative concept. The project reimagines objects from an initial art installation …

Gender Representation Of Composers In Recommended Wind Band Literature And Prominent Performances, Devon Alexis Gray Porter

USF Tampa Graduate Theses and Dissertations

The purpose of this research was to evaluate gender representation in recommended literature in wind band repertoire and prominent performances. I collected data from music lists approved by the National Band Association (NBA) state chapters, programs from the Midwest Clinic and College Band Directors National Association, music vendor catalogues, the Teaching Music Through Performance in Band series, and Florida Bandmasters Association (FBA) Music Performance Assessment (MPA) past performances. I evaluated names of composers to determine the male-female ratios and quantities for recommended works from these sources. I conducted further analysis to determine if trends existed in the relationships between composer …

Leveraging Chorionic Villus Biopsies For The Derivation Of Patient-Specific Trophoblast Stem Cells., Kaela Varberg, Ayelen Moreno-Irusta, Allynson Novoa, Brynne Musser, Joseph M. Varberg, Jeremy P. Goering, Irfan Saadi, Khursheed Iqbal, Hiroaki Okae, Takahiro Arima, John Williams, Margareta D. Pisarska, Michael J. Soares

Manuscripts, Articles, Book Chapters and Other Papers

Human trophoblast stem (TS) cells are informative in vitro models for the generation and testing of biologically meaningful hypotheses. The goal of this project was to derive patient-specific TS cell lines from clinically available chorionic villus biopsies. Cell outgrowths were captured from human chorionic villus tissue specimens cultured in modified human TS cell medium. Cell colonies emerged early during the culture and cell lines were established and passaged for several generations. Karyotypes of the newly established chorionic villus-derived trophoblast stem (TS^CV) cell lines were determined and compared to initial genetic diagnoses from freshly isolated chorionic villi. Phenotypes of …

The Association Between Sexually Transmitted Infections And Pregnancy Outcomes In The Northern Territory, Australia: A Population-Based Cohort Study, Jennifer Dunne, Gizachew A. Tessema, Matthew Legge, Sylvester Dodzi Nyadanu, Aditi Roy, Amanuel T. Gebremedhin, Jacqueline Hendriks, Tricia Reid-Moore, Gavin Pereira

Research outputs 2022 to 2026

Background: Often asymptomatic in nature, sexually transmitted infections (STIs) are highly prevalent in women of reproductive ages, leading to adverse perinatal outcomes. This study investigated the association between STIs during pregnancy and the risk of adverse perinatal outcomes using comprehensive population-linked data from the Northern Territory (NT), Australia. Methods: This population-based retrospective cohort study examined births (live births and stillbirths) from the NT Perinatal Data Collection and the NT Notifiable Diseases register from 2005 to 2020. All singleton births (N = 59,465) were included, along with infectious disease notifications of four STIs that occurred during pregnancy: chlamydia, gonorrhoea, trichomoniasis, and …

The Challenges Of Using Ultrasound To Measure The Trachea: A Brief Report, Helen Newman, Jodi Allen, Madan Narayanan, Nchafatso Obonyo, Nur Syahrunnizar, Karen Hammet, David Parry, Sarah Wallace, Anna-Liisa Sutt, Joseph Osterwalder, Daniel Martin

Peninsula Medical School

BACKGROUND: Tracheostomy is a common procedure in intensive care medicine, involving the insertion of an artificial airway through the front of the neck into the trachea. The size of tracheostomy tube in relation to the trachea is important, influencing clinical outcomes and patient experience. Ultrasound is readily available at the bedside and airway applications have been reported, including airway measurement. However, the presence of air within airway lumina presents challenges to ultrasound and causes artefact. Guidance is lacking on tracheal sonography and measurement.

AIM: to characterize the sonoanatomy of the inner tracheal wall and determine reference points for measuring tracheal …

Pollination And Essential Oil Production Of Lavandula Angustifolia Mill. (Lamiaceae), Riley B. Jackson, Tyler M. Wilson, Joseph S. Wilson, Zabrina Ruggles, Lindsey Topham Wilson, Chris Packer, Jacob G. Young, Christopher R. Bowerbank, Richard E. Carlson

Biology Faculty Publications

Lavandula angustifolia Mill., lavender, is an aromatic plant in the Lamiaceae family. Lavender, which is native to the Mediterranean region but cultivated throughout the world, is an important economic plant. Several studies have investigated two aspects of this aromatic plant: (1) which pollinators, particularly bees, pollinate lavender, and (2) the composition of lavender essential oil. However, little research has been conducted to investigate how pollination affects either the yield or phytochemistry of lavender. The current study, which was conducted in North America, investigates which bee species visit lavender and how pollination affects plant chemistry, specifically the essential oil produced by …

Volume 34, Number 2, Summer/Fall 2025, Office Of Communications, Illinois Wesleyan University

Illinois Wesleyan University Magazine, 2018-present

VOLUME 34 | NUMBER 2 | Summer/Fall 2025

ON OUR COVER:

The Illinois Wesleyan University archives, housed on the fourth floor of The Ames Library, holds many artifacts of IWU history, including the original university charter and a gold medal awarded to John Marden, clas of 1909, for his breakthrough work in atomic science and engineering.

18 175 Years of Illinois Wesleyan University. Celebrate IWU's history with a timeline of the last 175 years of our community's milestones.

26 Alumni Award Winners. Meet our Award Winners John Camardella '03, Natalie Lalagos '12, and Carol Willis '68.

Carbohydrate Metabolism In The Intercaruncular Endometrium Is Affected By Form Of Supplemental Selenium At Maternal Recognition Of Pregnancy In Beef Heifers, Sarah N. Carr, Benjamin R. Crites, Kwangwon Son, Phillip J. Bridges

Animal and Food Sciences Faculty Publications

Selenium (Se)-deficient soils result in Se-deficient forages that do not meet the nutritional requirement for this trace mineral in grazing cattle. Supplementation of Se conventionally occurs through a basal vitamin/mineral mix containing Se in an inorganic form (ISe), although organic Se (OSe) is available when cattle graze on forage. We previously reported that the provision of supplemental Se as a 1:1 mixture of ISe:OSe (MIX), in contrast to the industry standard of ISe alone, increases early luteal phase concentrations of systemic progesterone (P4) and increases the length of the conceptus at day 17 of pregnancy. The objectives herein were to …