Digital Commons Network^™

2′-3′-Cyclic Nucleotide 3′-Phosphodiesterase Inhibition By Organometallic Vanadium Complexes: A Potential New Paradigm For Studying Cns Degeneration, David C. Platt, Jonathan Rink, Kamaljit Braich, Craig C. Mclauchlan, Marjorie A. Jones

Faculty Publications – Chemistry

The enzyme, 2′-3′-cyclic nucleotide 3′-phosphodiesterase (CNPase) has been known for over fifty years. Nevertheless, the roles this membrane-bound enzyme play have yet to be described completely. Recently, there has been renewed interest in the study of this enzyme due to studies that suggest that CNPase plays a role in the mediation of cellular inflammatory responses in renal and nervous system tissues. Also, this enzyme, found in oligodendrocytes of the nervous system, has been reported to participate in significant regulatory changes associated with age which may be involved in age-related CNS degeneration. Consequently, development of CNPase inhibitors is of interest and …

Subsumption Reduces Dataset Dimensionality Without Decreasing Performance Of A Machine Learning Classifier, Donald C. Wunsch, Daniel B. Hier

Chemistry Faculty Research & Creative Works

When Features in a High Dimension Dataset Are Organized Hierarchically, There is an Inherent Opportunity to Reduce Dimensionality. Since More Specific Concepts Are Subsumed by More General Concepts, Subsumption Can Be Applied Successively to Reduce Dimensionality. We Tested Whether Sub-Sumption Could Reduce the Dimensionality of a Disease Dataset Without Impairing Classification Accuracy. We Started with a Dataset that Had 168 Neurological Patients, 14 Diagnoses, and 293 Unique Features. We Applied Subsumption Repeatedly to Create Eight Successively Smaller Datasets, Ranging from 293 Dimensions in the Largest Dataset to 11 Dimensions in the Smallest Dataset. We Tested a MLP Classifier on All …

A Deep Learning Model To Predict Traumatic Brain Injury Severity And Outcome From Mr Images, Dacosta Yeboah, Hung Nguyen, Daniel B. Hier, Gayla R. Olbricht, Tayo Obafemi-Ajayi

Chemistry Faculty Research & Creative Works

For Many Neurological Disorders, Including Traumatic Brain Injury (TBI), Neuroimaging Information Plays a Crucial Role Determining Diagnosis and Prognosis. TBI is a Heterogeneous Disorder that Can Result in Lasting Physical, Emotional and Cognitive Impairments. Magnetic Resonance Imaging (MRI) is a Non-Invasive Technique that Uses Radio Waves to Reveal Fine Details of Brain Anatomy and Pathology. Although MRIs Are Interpreted by Radiologists, Advances Are Being Made in the Use of Deep Learning for MRI Interpretation. This Work Evaluates a Deep Learning Model based on a Residual Learning Convolutional Neural Network that Predicts TBI Severity from MR Images. the Model Achieved a …

Icwa’S Irony, Marcia A. Yablon-Zug

Faculty Publications

The Indian Child Welfare Act (ICWA) is a federal statute that protects Indian children by keeping them connected to their families and culture. The Act’s provisions include support for family reunification, kinship care preferences, cultural competency considerations and community involvement. These provisions parallel national child welfare policies. Nevertheless, the Act is relentlessly attacked as a law that singles out Indian children for unique and harmful treatment. This is untrue but, ironically, it will be if challenges to the ICWA are successful. To prevent this from occurring, the defense of the Act needs to change. For too long, this defense has …

The Bounds Of Energy Law, Shelley Welton

Faculty Publications

U.S. energy law was born of fossil fuels. Consequently, our energy law has long centered on the material and legal puzzles that bringing fossil fuels to market presents. Eliminating these same carbon-producing energy sources, however, has emerged as perhaps the most pressing material transformation needed in the twenty-first century—and one that energy law scholarship has rightfully embraced. Yet in our admirable quest to aid in this transformation, energy law scholars are largely writing into the field bequeathed to us, proposing changes that tweak, but do not fundamentally challenge, last century’s tools for managing the extraction, transport, and delivery of fossil …

Analysis Of Geotagging Behavior: Do Geotagged Users Represent The Twitter Population?, Amir Karami, R. R. Kadari, L. Panati, H. Bheemreddy, B. Bozorgi

Faculty Publications

Twitter’s APIs are now the main data source for social media researchers. A large number of studies have utilized Twitter data for diverse research interests. Twitter users can share their precise real-time location, and Twitter APIs can provide this information as longitude and latitude. These geotagged Twitter data can help to study human activities and movements for different applications. Compared to the mostly small-scale data samples in different domains, such as social science, collecting geotagged data offers large samples. There is a fundamental question whether geotagged users can represent non-geotagged users. While some studies have investigated the question from different …

Feedback Control Of Fed-Batch Cultures Using Raman Spectroscopy For Metabolite Estimation, Brian Hadley

Master's Theses and Capstones

The monitoring and control of mammalian cell culture processes are critical for the safe and cost-effective development of biotherapeutics in drug development. Current control using off line sampling is infrequent and can miss important metabolic shifts which can impact product quality and consistency. Raman spectroscopy can provide in-line monitoring of multiple metabolites and critical process parameters to allow automation and process improvements. In this research a generic model was developed for monitoring multiple cell lines with a platform Chinese hamster ovary (CHO) cell process. Parameter estimation was then used for the implementation of feedback control. Two nutrient feeds were added …

An Interview With Michael Barresi, Michael J.F. Barresi, Alex Eve

Biological Sciences: Faculty Publications

Michael Barresi is Professor of Biological Sciences at Smith College, Northampton, MA, USA, where he uses the zebrafish to understand central nervous system development. Michael is also Program Director of the ‘Student Scientists’ outreach project and has made significant contributions to teaching developmental biology, including being co-author and illustrator of the textbook Developmental Biology, producing developmental documentaries and starting the Online Developmental Teaching Forums. He was awarded the 2021 Viktor Hamburger Outstanding Educator Prize from the Society of Developmental Biology (SDB). We caught up with Michael over Teams to hear more about his career and love of learning.

2021 Faculty Summer Seminar - From Facts To Truth To Wisdom With Thomas Aquinas, Center For Catholic Studies, Seton Hall University

Center for Catholic Studies Faculty Seminars and Core Curriculum Seminars

Michael Ambrosio - From Aquinas to Lonergan and Finnis: The Study and Teaching of Natural Law p.7

Xue-Ming Bao - Understanding Fact, Truth, and Wisdom During the COVID-19 Pandemic Through Lonergan and Aquinas p.16

Andrea Bartoli - From Facts to Truth to Wisdom with St. Thomas Aquinas p.19

Beth Bloom - A Monk and His Cat p.22

Margaret Brady-Amoon - Reflections on From Facts to Truth to Wisdom with St. Thomas Aquinas and Counseling Psychology p.25

Josephine Devito - Evidence Based Practice in Nursing p.28

Anthony Haynor - Can Aquinas Speak to Human Scientists Today? p.31

Jamie Marner - From …

The Role Of Vocal Hostility On Mood: Initial Development Of An Alternative Stress Paradigm, Jaquoy Sowell, Jennifer Gray, Christa C. Christ

University of South Carolina Upstate Student Research Journal

Maltreatment, such as physical or emotional abuse, can alter one’s later emotional regularity and responses to stimuli. To be able to study the effect of maltreatment on later stimuli response, appropriate laboratory paradigms need to be available, which is not currently true. The purpose of the study was to investigate the effect of vocal hostility stimuli on mood change as preliminary steps toward the creation of a laboratory paradigm. Participants were recruited from a regional university in southeast United States and asked to react to recorded audio with a hostile tone. Study 1 found that participants’ mood did not differ …

Agricultural Service Disparities Between White And Non-White Farmers Provided By The Federal Extension Service During The Jim Crow Era, José Leonel Ramírez Solís, Ben Montgomery

University of South Carolina Upstate Student Research Journal

The Federal Extension Service (FES) of the United States Department of Agriculture (USDA) was segregated during the Jim Crow era. FES farm agents provided agricultural education and outreach; they answered questions in office, hosted meetings, and made farm visits. Agents also ran 4-H, which educated youth about agriculture through camps, and demonstrated farming activities carried out by participants. This study investigated whether segregation of services led to disparities between white and non-white (mostly African American) farm operators and families among four South Carolina regions. We compared the level of service provided to white and non-white operators and youth based on …

Treatment Of Sars-Cov-2 Pneumonia With Favipiravir: Early Results From The Egeuniversity Cohort, Turkey, Hüseyi̇n Aytaç Erdem, Pervi̇n Korkmaz Ekren, Derya Çağlayan, Meltem Taşbakan, Tansu Yamazhan, Mehmet Sezai̇ Taşbakan, Abdullah Sayiner, Ayşe Deni̇z Gökengi̇n

Turkish Journal of Medical Sciences

Background/aim: The aim of this descriptive article is to share the experience in Ege University, Turkey with favipiravir in the treatment of severe SARS-CoV-2 pneumonia. Materials and methods: This retrospective descriptive study included patients diagnosed with COVID-19 who presented with or developed severe pneumonia. Results: Forty patients who completed a full course (at least 5 days) of favipiravir were included in the study. At baseline, 30 (75%) patients required treatment for respiratory distress. Thirty-three patients (82.5%) were discharged from the hospital with full recovery, 6 patients (15%) died and 1 case (2.5%) was still at the intensive care unit (ICU) …

Comparison Of Greater Occipital Nerve And Greater Occipital Nerve + Supraorbital Nerveblock Effect In Chronic Medication Overuse Headache, Nermi̇n Tepe, Oktay Faysal Tertemi̇z

Turkish Journal of Medical Sciences

Background /aim: In this study, we aimed to compare the efficacy of greater occipital nerve (GON) block alone and GON combined with supraorbital nerve (SON) block in the treatment of medication overuse headache (MOH). Material and methods: 82 patients were divided into two groups: 41 patients were administered bilateral GON block while the other 41 patients GON + SON block. Nerve blocks were administered every 10 days for a total of 5 sessions. After each administration and 20 days after the last injection, information on pre and post treatment numerical rating scale (NRS) score, number of painful days, analgesic intake, …

Clinical And Molecular Findings In 37 Turkish Patients With Isolated Methylmalonic Acidemia, Berna Şeker Yilmaz, Deni̇z Kör, Fatma Derya Bulut, Sebi̇le Kilavuz, Serdar Ceylaner, Hali̇se Nesli̇han Önenli̇ Mungan

Turkish Journal of Medical Sciences

Background/aim: Isolated methylmalonic acidemia (MMA) is caused by complete or partial deficiency of the enzyme methylmalonylCoA mutase (mut0 or mut- enzymatic subtype), a defect of its cofactor adenosyl-cobalamin (cblA, cblB, or cblD-MMA), or deficiency of the enzyme methylmalonyl-CoA epimerase. While onset of the disease ranges from the neonatal period to adulthood, most cases present with lethargy, vomiting and ketoacidosis in the early infancy. Major secondary complications are; growth failure, developmental delay, interstitial nephritis with progressive renal failure, basal ganglia injury and cardiomyopathy. We aimed to demonstrate clinical and molecular findings based on long-term follow up in our patient cohort. Materials …

Pancreas And Kidney Changes In Type 2 Diabetes Patients: The Role Of Diffusion-Weightedimaging, Mehmet Hamdi̇ Şahan, Adnan Özdemi̇r, Neşe Asal, Mi̇race Yasemi̇n Karadeni̇z Bi̇lgi̇li̇, Adi̇l Doğan, Aşkin Güngüneş

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to compare renal and pancreatic apparent diffusion-coefficient (ADC) values of diabetic patients and control subjects and to examine their potential association with several diabetes-related clinical parameters. Materials and methods: A total of 80 sex- and age-matched patients were included in the study. Of them, 40 were patients with type 2 diabetes and 40 were nondiabetic participants. Abdominal diffusion-weighted MRIs of both groups were retrospectively reviewed. Diabetes-related clinical parameters were recorded. Results: The difference between the mean ADC values of the patient group and the control group was significant (p = 0.012). It was …

Effects Of Intraoperative Blood Loss During Liver Resection On Patients? Outcome: A Singlecenter Experience, Muhammed Seli̇m Bodur, Kadi̇r Tomas, Serdar Topaloğlu, Şükrü Oğuz, Hakan Küçükaslan, Davut Dohman, Erdem Karabulut, Adnan Çalik

Turkish Journal of Medical Sciences

Background/aim: Operative bleeding is one of the major determinants of outcome in liver surgery. This study aimed to describe the impact of intraoperative blood loss on the postoperative course of liver resection (LR). Materials and methods: The data of 257 patients who were treated with LR between January 2007 and October 2018 were retrospectively analyzed. LRs were performed via intermittent portal triad clamping (PTC) under low central venous pressure. Results: LRs were performed for 67.7% of patients with a malignant disease and 32.3% of patients with a benign disease. Major LR was performed in 89 patients (34.6%). The mean PTC …

The Effects Of Water Immersion And Epidural Analgesia On Cellular Immune Response,Neuroendocrine, And Oxidative Markers, Özlem Uzunlar, Ümi̇t Yasemi̇n Sert Di̇nç, Nezaket Kadioğlu, Tuba Çandar, Yaprak Üstün

Turkish Journal of Medical Sciences

Background/aim: Water immersion and epidural analgesia are the most preferred pain relief methods during the labor process. Adverse effects related to these methods, impact on the labor, and perception of pain is well studied in the literature. We aimed to investigate the cord blood level of copeptin, total serum oxidant (TOS), antioxidant (TAS), interleukin (IL)-1, IL-6, and oxytocin after the labor with water immersion, epidural analgesia, and vaginal birth without pain relief. Materials and methods: The study was conducted with 102 healthy pregnant women admitted to the obstetric delivery unit for noncomplicated term birth. Copeptin, oxytocin, TAS, TOS, IL-1, and …

Genistein Suppresses The Inflammation And Gsk-3 Pathway In An Animal Model Ofspontaneous Ovarian Cancer, Füsun Erten, Engi̇n Yeni̇ce, Cemal Orhan, Beşi̇r Er, Pinar Demi̇rel Öner, Patrick Brice Defo Deeh, Kazi̇m Şahi̇n

Turkish Journal of Medical Sciences

Background/aim: Numerous studies show that cancer risk is reduced by consumption of soy-based foods containing genistein, but its effects on the glycogen synthase kinase-3 pathway (GSK-3) in ovarian cancer is unknown. Therefore, we tested the properties of genistein on inflammatory biomarkers and GSK-3 signaling pathways in the ovaries of old laying hens with ovarian cancer. Materials and methods: A total of 300 laying hens were distributed into three groups as follows: group 1, animals fed a standard diet (comprising 22.39 mg of genistein/kg of diet); groups 2 and 3, animals fed a standard diet reconstituted with supplementation of 400 mg …

Effect Of Betulinic Acid Administration On Tlr-9/Nf-Κb /Il-18 Levels In Experimentalliver Injury, Eda Dokumacioğlu, Hati̇ce İskender, Kübra Asena Teri̇m Kapaki̇n, Güler Yeni̇ce, Behzat Mokthare, İsmai̇l Bolat, Armağan Hayirli

Turkish Journal of Medical Sciences

Background/aim: Acetaminophen (APAP), used in the composition of thousands of preparations, is the most commonly used analgesic and antipyretic drug. The present study aimed to investigate the potential protective effects of the betulinic acid (BA) treatment through an APAP-induced hepatotoxicity rat model, using inflammatory, biochemical, and histopathological parameters. Materials and methods: The study consisted of four groups: control group, APAP group, BA group, and APAP+BA group. Experimental studies continued for fifteen days. Serum samples were analysed for glucose, total cholesterol (TChol), triglyceride (TG), low density lipoprotein (LDL), high density lipoprotein (HDL), aspartate amino transferase (AST), malondialdehyde (MDA), toll-like receptor-9 (TLR-9), …

The Hidden Gender Of Gender-Neutral Paid Parental Leave: Examining Recently-Enacted Law In The United States And Australia, Deborah A. Widiss

Articles by Maurer Faculty

The United States and Australia are unusual in their approach to providing paid time off to new parents. Virtually every other country in the world provides maternity leaves that are far longer than paternity leaves, even if they also provide supplemental parental leave available to either parent. Recently-enacted laws in the United States and Australia, by contrast, eschew sex-specific classifications entirely. But, while both adopt gender-neutral approaches, they are structured quite differently. American laws provide each parent equal and non-transferable benefits; Australian law provides an extended period of benefits to a “primary” caregiver, and a much shorter period of benefits …

The Biopolitics Of Maskless Police, India Thusi

Articles by Maurer Faculty

Despite the recent movement against police violence, police officers have been endangering their communities by engaging in a new form of violence— policing while refusing to wear facial coverings to prevent the spread of COVID-19. Many states advise people to wear masks and to socially distance when in public spaces. However, police officers have frequently failed to comply with these guidelines as they interact with the public to enforce these COVID-19 laws. Police enforcement of COVID-19 laws is problematic for two reasons: (1) it provides a method for pathologizing marginalized communities as biological threats; (2) it creates a racialized pathway …

After Class: What's Next For School Library Research, Barbara Schultz-Jones, Marcia Mardis, Sue Kimmel

STEMPS Faculty Publications

The research process of the CLASS II research agenda is detailed along with findings from the formal final report of the project. Findings are organized by using the shared foundations from the 2017 AASL National School Library Standards and include highlights from the aggregated research. A discussion of innovative future directions for school library research builds on the CLASS II research findings.

Fly In The Face Of Bias: Algorithmic Bias In Law Enforcement's Facial Recognition Technology And The Need For An Adaptive Legal Framework, Peter N.K. Schuetz

Minnesota Journal of Law & Inequality

No abstract provided.

Diagnostic Performance Of Shear Wave Elastography And Diffusion-Weighted Magneticresonance Imaging In Cervical Lymph Nodes: A Comparative Study, Veli̇ Süha Öztürk, Ersen Erteki̇n

Turkish Journal of Medical Sciences

Background/aim: To investigate the potential diagnostic value of point shear wave elastography (pSWE) and the contribution of concurrent diffusion weighted magnetic resonance imaging (DW-MRI) to diagnostic performance in patients with cervical lymphadenopathy. Materials and methods: This cross-sectional study included 116 cervical lymph nodes of 94 patients. All lymph nodes were evaluated before the treatment or histopathological sampling. Gray scale ultrasonographic features, elastographic stiffness and apparent diffusion coefficient (ADC) values were measured and recorded. Lymph nodes were divided into benign and malignant groups with histopathological findings. Results: Short axis measurement, axis ratio, hilum morphology, vascularization patterns, pSWE, and ADC values were …

Giant Hepatic Hemangioma Treatment With Transcatheter Arterial Embolisation Andtranscatheter Arterial Chemoembolisation; Comparative Results, Özhan Özgür, Hakki Ti̇mur Si̇ndel

Turkish Journal of Medical Sciences

Background/aim: Treatment of hepatic hemangiomas is a controversial topic, and traditional treatment is surgical excision. Transcatheter arterial embolisation (TAE) and transcatheter arterial chemoembolisation (TACE) have been reported as minimally invasive treatment methods. To the best of our knowledge, there are no studies comparing use of TACE and TAE for hepatic hemangioma treatment. The aim of the study is to compare symptom resolution, size reducing effects, and complications of TACE and TAE for the treatment of giant hepatic hemangiomas. Materials and methods: A total of 104 patients underwent TACE using bleomycin, and 108 patients underwent TAE. The patients were followed-up for …

Differentiation Of Benign And Malignant Superficial Soft Tissue Lesions Using Real-Timestrain Elastography, Gökçe Annaç, Murat Canyi̇ği̇t, Si̇nan Tan, Ersi̇n Akşam, Nuran Süngü, Hali̇l Arslan

Turkish Journal of Medical Sciences

Background/aim: To evaluate benign and malignant cutaneous-subcutaneous lesions using real-time strain elastography (RTSE) and to compare the findings with histopathologic results. Materials and methods: Over a period of 10 months, 72 patients (38 with benign and 34 with malignant cutaneous and subcutaneous lesions) were prospectively included in this study. Elasticity patterns and strain ratios were examined for each lesion. Lesions were evaluated in 4 groups as yellow-red (soft; pattern-1), green-yellow (moderate; pattern-2), blue-green (hard; pattern-3) and blue (hardest; pattern-4). The stiffness of the lesions was displayed with strain ratios by comparing of a nearby reference tissue. The recorded images were …

Distal Spread And Tumor Regression Patterns Following Preoperative Chemoradiotherapyin Rectal Cancer Patients, İlter Özer, Nesli̇han İnci̇ Zengi̇n, Haci Murat Çayci, Adem Yüksel, Tahsi̇n Dalgiç, Murat Ulaş, Erdal Bi̇rol Bostanci, Musa Akoğlu

Turkish Journal of Medical Sciences

Background/aim: This study aimed to evaluate the regression pattern with the distal intramural spread (DIS) of rectum cancer after preoperative chemoradiation. Materials and methods: Specimens from 56 patients who underwent radical resection after preoperative chemoradiation for rectal cancer were examined. The regression pattern (total, fragmented) of the tumor was recorded. DIS status was evaluated by creating sections 0.2 to 0.3 cm thick. Results: A single macroscopic residual area was detected in all specimens. In 10 patients (17.8 %), pathologically complete responses were identified, and DIS was detected in 33 patients (58.9%). The average DIS distance was 0.56 ± 0.3 cm …

Investigation Of The Correlation Between Mood Disorder Symptoms And Disease Activityand Functional Status In Rheumatoid Arthritis Patients, Meli̇h Pamukcu, Tuğba İzci̇ Duran, Hasan Ulusoy, Kürşat Altinbaş

Turkish Journal of Medical Sciences

Background/aim: To investigate the correlation between depressive-anxiety symptoms, mixed features, disease activity, and functional status in patients with rheumatoid arthritis (RA) in the light of the shared underlying etiology in both disorders. Materials and methods: The study included 556 patients with RA. RA disease activity was measured using the Disease Activity Score 28-joint count C reactive protein (DAS28-CRP), and the patients were evaluated by a Health Assessment Questionnaire (HAQ). The Hospital Anxiety and Depression Scale (HADS), Mood Disorder Questionnaire (MDQ), and Modified Hypomania Checklist (mHCL) were used to evaluate the mixed depression and bipolarity status of the patients. Results: Of …

The Potential Role Of Human Hiv-1 Tat-Interactive Protein 2levels In The Pathogenesis Of Contact Dermatitis, Mahmut Sami̇ Meti̇n, Handan Bi̇len, Ömer Faruk Elmas, Necmetti̇n Akdeni̇z

Turkish Journal of Medical Sciences

Background/aim: Human HIV-1 TAT interactive protein 2 (HTATIP2/TIP30) is a gene that is extensively expressed in human tissues as well as in tumor tissues. This study aimed to explore the potential role of HTATIP2/TIP30 in contact dermatitis (CD), which is one of the most common inflammatory cutaneous conditions. Materials and methods: This cross-sectional study involved adult patients with acute contact dermatitis who were admitted to the outpatient dermatology clinic of a tertiary hospital and healthy adult volunteers without any cutaneous or systemic diseases. The blood concentration of HTATIP2/TIP30 was measured using ELISA kits. Results: The research sample consisted of 31 …

Three-Dimensional Assessment Of Pharyngeal Airway In Individuals With Myotonicdystrophy Type 1, Burcu Evli̇ce, Ayşe Fi̇li̇z Koç, Hazal Duyan, Damla Soydan Çabuk

Turkish Journal of Medical Sciences

Background/aim: The objectives of this study were to assess pharyngeal airway volume (PAV) in patients with myotonic dystrophy type 1 (DM1) by cone-beam computerized tomography (CBCT) and to evaluate the impact of diaphragm thickness and pulmonary function tests on PAV. Materials and methods: Thirty DM1 patients (10 female and 20 male; mean age 42.40 ± 12.07) were included in the study. Age and sex-matched thirty patients were participated as control group. In DM1 group pulmonary function tests (PFT) were performed. Independent t-test was used to compare PAV values of patients with DM1 and control group. The Mann-Whitney U test was …