Digital Commons Network^™

A Simple Action Reduces High-Fat Diet Intake And Obesity In Mice, M. R. Barrett, Y. Pan, C. L. Murrell, E. O. Karolczak, J. Wang, L. Z. Fang, J. M. Thompson, Y.-H. Chuang, E. Casey, J. E. Czarny, W. L. So, A. Reichenbach, R. Stark, H. Taghipourbibalan, S. R. Penna, K. B. Mccullough, S. R. Westbrook, G. C. Basu, B. Matikainen-Ankney, V. A. Cazares, K. Delevich, Wambura C. Fobbs, S. E. Maloney, A. S. Hickey, J. E. Mccutcheon, Z. B. Andrews, M. C. Creed, M. J. Krashes, A. V. Kravitz

Psychology Faculty Works

Diets that are high in fat cause overeating and weight gain in multiple species of animals, suggesting that high dietary fat is sufficient to cause obesity. However, high-fat diets are typically provided freely to animals in obesity experiments, so it remains unclear whether high-fat diets would still cause obesity if these diets required more effort to obtain. We hypothesized that unrestricted access to high-fat diets is important for these diets to induce overeating and that requiring mice to perform small amounts of work to obtain a high-fat diet would reduce calorie intake and associated weight gain. To test this hypothesis, …

Thrombocytopenia In Patients With Plasmodium Vivax In Colombia Is Associated With Anti-Phosphatidylserine Autoantibodies And Il-6, Ifnγ, Il-10 And Tgf-Β, María Camila Velasco-Pareja, Catalina Tovar-Acero, Miriam E. Cantero Guevara, Ana Rodriguez, Juan Rivera-Correa, María Fernanda Yasnot-Acosta

Publications and Research

Plasmodium vivax is the most widely distributed human protozoan in the world. It is a causative agent of malaria, with thrombocytopenia being a frequent complication. This study aimed to evaluate the effect of P. vivax infection on plasma cytokine/chemokine levels and anti-phosphatidylserine (anti-PS) autoantibodies, to explore their potential role in thrombocytopenia during P. vivax malaria in Córdoba, Colombia. We included patients with P. vivax malaria and thrombocytopenia (MT); patients with malaria without thrombocytopenia (M) and healthy controls (HC). Plasma cytokines/chemokines (IL-2, IL-4, IL-1β, TNF-α, IL-17A, IL-6, IL-10, IFNγ, IL-12p70, TGF-β1/IP-10, MCP-1, IL-8) were quantified. Evaluation of autoantibodies was performed by …

Ethical Implications Of Being A Holobiont, Scott F. Gilbert

Biology Faculty Works

Developmental plasticity and holobiont theory have undermined the normative concepts of biological individuality. However, such traditional ideas of biological individuality have helped define and support Western ethical views into the 21st century. Guided by some of the ethical formulae of Simone Weil, Hans Jonas, and Alastair MacIntyre, this essay attempts to outline some possible trajectories for an ethics that is bounded by these new biological paradigms of environmental agency. Specifically, the ecological developmental biology concepts of plasticity and holobiont theory permit the “ethics of attention” to focus on the partnerships of living beings. Highlighting environmentally integrated life cycles and their …

Algorithmic Optimization Of Filter Bank: Harnessing Rapid Convergence And Its Applications, Keerthana B Ms

Theses and Dissertations

A novel optimization framework is proposed for the design of both uniform and non-uniform filter banks, aimed at improving the accuracy and computational efficiency of biomedical signal classification tasks, with a particular emphasis on the detection of sleep disorders and Alzheimer’s disease.The proposed algorithm is grounded in multirate signal processing theory and aims to achieve Near Perfect Reconstruction (NPR) with minimal computational overhead. The process begins with the optimization of a uniform cosine-modulated filter bank (CMFB), achieved through iterative frequency-domain analysis and parameter tuning. This is followed by the derivation of a non-uniform filter bank via selective merging of bandpass …

Polylactic Acid (Pla)-Based Multifunctional And Biodegradable Nanocomposites And Their Applications, Md Shariful Islam, G. M. Fazley Elahee, Xiong (Bill) Yu, Rigoberto Castillo Advincula, Changyong (Chase) Cao

Faculty Scholarship

Polylactic acid (PLA)-based nanocomposites are emerging as multifunctional, biodegradable materials, offering sustainable alternatives to petroleum-based plastics. This review examines recent advancements in PLA nanocomposites, focusing on enhanced mechanical strength, thermal stability, and biodegradability achieved through nanofillers like metallic particles, carbon-based materials, and ceramics. Techniques such as in situ polymerization, melt mixing, and electrospinning enable application-specific improvements. PLA's limitations, including brittleness and low barrier properties, are addressed to support diverse applications: in packaging (e.g., extended shelf life), biomedicine (e.g., degradable implants), and electronics (e.g., flexible devices). Despite challenges with filler dispersion and thermal resistance, continued innovations expand PLA's potential across multiple …

Algorithmic Optimization Of Filter Bank: Harnessing Rapid Convergence And Its Applications, Keerthana B

Theses and Dissertations

A novel optimization framework is proposed for the design of both uniform and non-uniform filter banks, aimed at improving the accuracy and computational efficiency of biomedical signal classification tasks, with a particular emphasis on the detection of sleep disorders and Alzheimer’s disease. The proposed algorithm is grounded in multirate signal processing theory and aims to achieve Near Perfect Reconstruction (NPR) with minimal computational overhead. The process begins with the optimization of a uniform cosine-modulated filter bank (CMFB), achieved through iterative frequency-domain analysis and parameter tuning.

This is followed by the derivation of a non-uniform filter bank via selective merging of …

A Comprehensive Deep Learning System With Mgrf Modeling For Predicting Breast Cancer Response To Neoadjuvant Chemotherapy, Ahmed Sharafeldeen, Fatma Taher, Norah Saleh Alghamdi, Eman Alnaghy, Reham Alghandour, Khadiga M. Ali, Sameh Shamaa, Abdelrahman Gamal, Mohammed Ghazal, Sohail Contractor, Ayman El-Baz

All Works

Accurate prediction of breast cancer (BC) response to neoadjuvant chemotherapy (NAC) is critical for tailoring treatment strategies and improving patient outcomes. This study introduces a novel deep learning-based framework that integrates multi-parametric magnetic resonance imaging (MRI) (i.e., T1, T2, STIR, and DWI), along with clinical and molecular subtype markers, to classify tumor response into pathological complete response (pCR), partial response (PR), and stable disease (SD). First, tumor regions are delineated across MRI modalities and then modeled using a translation-invariant Markov-Gibbs random field (MGRF) with analytical parameter estimation to capture modality-specific spatial appearance patterns correlated with NAC response. Subsequently, diffusion-weighted MRI …

Tlr4 Asp299gly Snp (Rs4986790) Protects From Periodontal Inflammatory Destruction By Altering Tlr4 Susceptibility To Lps Stimulation, Franco Cavalla, Cláudia Cristina Biguetti, Ariadne Letra, Renato Silva, Alexandre R. Vieira, Franz J. Strauss, Gustavo P. Garlet

School of Podiatric Medicine Publications

Simple Summary

Periodontitis is a common disease that affects the gums and the bone supporting the teeth, often leading to tooth loss. It results from a complex interaction between bacteria and the body’s immune response. Some people are more susceptible than others, and genetics may play a role. In this study, we focused on a genetic variation (called a polymorphism) in a gene known as TLR4, which helps the immune system recognize harmful bacteria. We examined over 1400 individuals from different populations and found that people carrying this specific variation, known as Asp299Gly, were less likely to develop severe periodontal …

Global Incidence Of Female Birdsong Is Predicted By Territoriality And Biparental Care In Songbirds, Karan J. Odom, Marcelo Araya-Salas, Lauryn Benedict, Kristi Lim, James Dale, Wesley H. Webb, Catherine Sheard, Joseph A. Tobias, Gregory F. Ball, Michelle L. Hall, Naomi E. Langmore, Michael S. Webster, Katharina Riebel

Pacific Faculty Work

Pronounced sexual dimorphism is generally assumed to evolve through sexual selection for elaborate male traits. However, there is increasing evidence that sexual dimorphism in traits such as birdsong may also evolve through loss of elaboration in females, but the evolutionary drivers underlying this process are obscure. Here we analyse ecological and natural history traits for over 1300 songbird species and show that increased female song incidence and elaboration are most directly associated with year-round territoriality, biparental care, and large body size. Phylogenetic path analysis indicates that mating system and breeding latitude primarily have indirect effects on female song evolution. Stable, …

Parents’ Experiences With Their Child’S Psychotherapy And Mental Illness, Valerie Marsman

Walden Dissertations and Doctoral Studies

Low parental engagement—especially among fathers and ethnic minority groups like Latinx parents—in child psychotherapy increases the risk of treatment dropout, behavioral issues, and poorer outcomes, contributing to persistent disparities. More research was needed on perceptual barriers and facilitators to parental engagement such as attitudes, beliefs, and expectations. The purpose of this study was to gain an in-depth understanding of parents’ experiences with their child’s psychotherapy and mental illness to facilitate parental engagement in services that support the child. An interpretative phenomenological approach and multiperspectival focus group design were used to illuminate each participant’s voice and explore overarching themes. Hill’s theory …

Bold New Bioweapons: Part 1 — The Burdens Of Detection And Attribution, James Giordano

Strategic Insights

This commentary, Pt. 1 of the Bold New Bioweapons series, examines how advances in gene editing, synthetic biology, and artificial intelligence are reshaping the biological weapons threat landscape and challenging the effectiveness of the Biological Weapons Convention (BWC). Dr. Giordano argues that decentralized research ecosystems, AI-enabled pathogen design, and dual-use biotechnology complicate detection, attribution, and deterrence. Emerging techniques can produce synthetic or modified biological agents that evade traditional surveillance systems and blur distinctions between legitimate research and weaponization. The absence of clear adjudication mechanisms within the BWC creates governance gaps exploitable by state and non-state actors. The article emphasizes that …

The Effect Of Tranexamic Acid On Blood Coagulation In Primary Total Hip Arthroplasty Using Rotational Thromboelastometry: A Randomized Controlled Trial, Uzung Yoon, David Beausang, Elia Elia, Marc Torjman, Jeffrey Mojica, James J. Purtill, David Nazarian, P. Maxwell Courtney, Yoogoo Kang

Department of Anesthesiology Faculty Papers

BACKGROUND: Tranexamic acid (TXA), is commonly administered prophylactically to reduce blood loss in patients undergoing total hip arthroplasty (THA). However, its effect has never been studied. We hypothesized that no difference exists in the degree of fibrinolysis and blood loss between patients receiving prophylactic TXA and placebo.

METHODS: This double-blinded randomized-controlled trial included 50 patients undergoing primary THA in 2021-2023. Clinicaltrials.gov (NCT03897621). Rotational-thromboelastometry (ROTEM) were performed to test blood coagulability using non citrated whole blood (NATEM) and blood treated with TXA (T-APTEM). The intervention group received TXA intravenously. The placebo group received 0.9% sodium chloride solution. The primary outcome measure …

Injury And Illness: An Analysis Of Team Usa Athletes At The 2024 Winter Youth Olympic Games, Ashley N. Triplett, Eric G. Post, Travis Anderson, Olivia Samson, Alexis D. Gidley, Francisco Silva, Lea Thomann, Amber T. Donaldson, Jonathan T. Finnoff, Eric L. Dugan, Jeffrey S. Shilt, William M. Adams

Department of Pediatrics Faculty Papers

BACKGROUND: Injury and illness surveillance is essential for understanding the relative risks of sports participation to develop effective strategies to optimize athlete health, wellness, and performance. Epidemiological studies examining injuries and illnesses among Team USA youth athletes are limited, particularly among athletes competing in Winter sports. The purpose of this study was to characterize the injury and illness incidence rate among Team USA athletes participating in the 2024 Winter Youth Olympic Games (YOG).

METHODS: Injuries and illnesses among 101 Team USA youth athletes (40.6% female; age, 17 ± 1 years) were prospectively documented. Injury and illness prevalence, and incidence rate …

School Counselors’ Perceptions On Providing Mental Health Services In Schools, Kimberly Davis

Walden Dissertations and Doctoral Studies

The increasing prevalence of mental health concerns among students in the United States has amplified the demand for comprehensive school-based mental health services. School counselors are often positioned as frontline providers of this support, yet research suggests they face numerous systemic and role-related challenges. This qualitative phenomenological study was conducted to explore school counselors’ perceptions of their roles in providing mental health services, the barriers they encounter, and the ways in which self-efficacy is shaped by these experiences. Ten school counselors from diverse school settings participated in semistructured interviews. Thematic analysis revealed five central themes: (a) roles and responsibilities, (b) …

Investigating The Necessity Of Adaptive Radiotherapy In Tomotherapy Of Head And Neck Cancer Patients, Ali Chaparian, Mahsa Kianinia, Mahnaz Roayaei, Nadia Najafizade, Abolfazl Kanani, Leili Mahani, Hamidreza Nourzadeh

Department of Radiation Oncology Faculty Papers

BACKGROUND: Anatomical variations that occur during radiation therapy in head and neck cancer (HNC) patients can lead to significant dosimetric changes. The purpose of this study is to evaluate dosimetric and volume changes in key anatomical structures for different treatment sites in HNC patients, and to determine the percentage of patients who need adaptive radiotherapy (ART) per treatment site.

METHODS: A total of 1,740 megavoltage computed tomography (MVCT) images from 58 HNC patients treated with helical tomotherapy (HT) were exported to the PreciseART™ (Accuray) software. Volume changes in the planning target volume (PTV) and the organs at risk (OARs) in …

The International Society For Clinical Spectroscopy; Reflections On The First 10 Years, Małgorzata Baranska, Hugh J. Byrne, Peter Gardner, Alex Henderson, Nick Stone, Bayden Wood

Research Outputs: 2025-Present

The article provides a perspective overview of the development and current status of the field of biomedical spectroscopy, on the occasion of the tenth anniversary of the foundation of the International Society for Clinical Spectroscopy (CLIRSPEC). It provides a background into the prior evolution of the field, and international community, and rationale for the foundation of the legal entity, CLIRSPEC. It describes the continued dissemination and educational activities associated with the society, and maps out key technical developments, as well as trends towards clinical translation, and future perspectives.

Monitoring The Kinetic Evolution Of Mesenchymal Stem Cell Differentiation Using Raman Microspectroscopy, Francesca Ravera, Esen Efeoglu, Hugh J Byrne

Research Outputs: 2025-Present

Raman microspectroscopy (RMS) offers a powerful, non-destructive approach for in situ monitoring of dynamic biochemical processes within cells. However, the ability to reliably data-mine the spectroscopic signatures and their evolution and extract meaningful information can be challenging. Multivariate Curve Resolution-Alternating Least Squares (MCR-ALS) regression analysis is a powerful chemometric technique that can potentially address this challenge by deconvoluting the spectra into individual component spectra, each representing a specific biochemical species, and regressing the solutions against kinetic constraints. In this study, MCR-ALS analysis was performed on spectral data of differentiation process of mesenchymal stem cells into chondrocytes, carried out on two …

The Effect Of Transformer Based Pre-Trained Language Models On Biomedical Relation Extractions, Eman Saad, Sherif Kishk, Amr Ali-Eldin, Ahmed I. Saleh

Mansoura Engineering Journal

Biomedical relation extraction represents a critical advancement in healthcare research. As the volume of biomedical publications continues to grow exponentially, efficient extraction of entity relationships has become essential for accelerating knowledge discovery, drug development, and precision medicine initiatives. The field has evolved from focusing on simple binary relations, such as Protein-Protein Interactions (PPI), which are fundamental to understanding cellular processes and therapeutic development, to addressing more complex multi-class classification challenges like Drug-Drug Interactions (DDI) and Chemical-Protein Interactions (CPI).Pre-trained language models have become the cornerstone of modern approaches of extracting biomedical relations. Models like BioBERT, PubMedBERT, and SciBERT, along with general-purpose …

Scorpions Of The Horn Of Africa (Arachnida: Scorpiones). Part Xl. Barbaracurus Lowei Sp. N. From Ethiopia (Buthidae), František Kovařík, Hassan Sh A. Elmi

Euscorpius

Barbaracurus lowei sp. n. from Ethiopia is described and compared with other species of the genus, fully complemented with color photos of specimens of both sexes of the new species, as well as of their habitat. Included is a key for Barbaracurus and a map of the distribution of the genus in the Arabian Peninsula and the Horn of Africa.

When Culture Becomes Law: Mayan Heritage And The New Constitutional Recognition Of Collective Rights In Mexico, José Israel Herrera, Victor Manuel Colli Ek

Journal of Maya Heritage

Abstract. The constitutional reform of September 30, 2024 to article 2 marks a substantive change in the recognition of indigenous peoples as subjects of public law, with their own patrimony, valid normative systems and express right to conserve, protect and develop their cultural, material and immaterial heritage. This article analyzes the legal implications of this reform in the context of the Maya people, especially with regard to collective intellectual property, the right to prior consultation and the constitutional recognition of bioculturality. A critical reading of the new normative framework is proposed, with emphasis on its transformative potential for the territorial …

Higher Blood Lipid Levels After The Transition To Menopause In Two Forager-Horticulturalist Populations, M. J. Getz, J. E. Aronoff, C. L. Jenkins, S. Ghafoor, J. Vazquez, N. T. Appel, M. Gatz, Daniel K. Cummings, Paul L. Hooper, B. Beheim, K. H. Buetow, C. E. Finch, G. S. Thomas, J. Stieglitz, M. Gurven, Hillard Kaplan, B. C. Trumble

ESI Publications

Background: Reproduction affects health and longevity among females across the life course. While significant focus has been devoted to the role of menarche, menopause remains understudied. Most menopause research is conducted in industrialized populations, where the risk of cardiovascular diseases increases progressively during the menopausal transition.

Methodology: Weworked with the Tsimane, Indigenous Bolivian forager-farmers with physically active lifestyles, and the Moseten, genetically and culturally related horticulturalists experiencing greater market integration. We assessed relationships between menopause status and lipid biomarkers (HDL, LDL, non-HDL, total cholesterol, triglycerides, and apolipoprotein-B). Using linear mixed-effects models, in an all-age sample of n = …

Pharmacogenetic Exploration Of Burenorphine And Related Metabolites In Umbilical Cord Blood, Amelia Monfared, Derek E. Murrell, Darshan S. Shah, Melissa Hoang, Stacy D. Brown, Sam Harirforoosh

Pharmacy Faculty Articles and Research

The goal of this study was to explore associations between single-nucleotide polymorphisms (SNPs) and umbilical cord blood concentrations of buprenorphine and its metabolites following maternal administration. This is a sub-study of a prospective observational cohort investigation which included pregnant women receiving buprenorphine for opioid use disorder during pregnancy. Following delivery, umbilical cord blood samples were collected and genotyped using a pharmacogenetic panel. The drug and metabolite concentrations were analyzed through liquid chromatography-mass spectrometry, and genetic association analysis was completed using PLINK software. The included neonates (n = 14) had a mean birth weight of 3.00 ± 0.39 kg and were …

Anti-Dirt Hand Sanitizer: A Zeolite-Enhanced Approach To Hygiene And Microbial Protection, Theo Uskoković, Evangelina Uskoković, Victoria Wu, Vuk Uskoković

Administration and Staff Articles and Research

Children love to play with dirt and their outdoor activities oftentimes make their hands heavily soiled. Meanwhile, improper sanitation of the hands prior to making contact with food or bodily fluids can result in potentially dangerous infection. In situations where handwashing is not available, hand sanitizers present a common cleaning agent of choice. However, as it is shown here, standard sanitizers, albeit acting effectively against skin microbes, do not have the ability to remove the dirt deposits off children's hands, where microbial colonies may remain protected against the antiseptic effect of the sanitizer. To circumvent this limitation, we designed and …

A Model Intercomparison Study Of Aerosol-Cloud-Turbulence Interactions In A Cloud Chamber: 1. Model Results, Sisi Chen, Steven K. Krueger, Piotr Dziekan, Kotaro Enokido, Theodore Macmillan, David Richter, Silvio Schmalfuß, Shin Ichiro Shima, Fan Yang, Jesse C. Anderson, Will Cantrell, Dennis Niedermeier, Raymond Shaw, Frank Stratmann

Michigan Tech Publications

This study presents the first model intercomparison of aerosol-cloud-turbulence interactions in a controlled cloudy Rayleigh-Bénard Convection chamber environment, utilizing the Pi Chamber at Michigan Technological University. We analyzed simulated cloud chamber-averaged statistics of microphysics and thermodynamics in a warm-phase, cloudy environment under steady-state conditions at varying aerosol injection rates. Simulation results from seven distinct models (DNS, LES, and a 1D turbulence model) were compared. Our findings demonstrate that while all models qualitatively capture observed trends in droplet number concentration, mean radius, and droplet size distributions at both high and low aerosol injection rates, significant quantitative differences were observed. Notably, droplet …

Potential Biological And Genetic Links Between Dementia And Osteoporosis: A Scoping Review, Abayomi N Ogunwale, Paul E Schulz, Jude K Des Bordes, Florent Elefteriou, Nahid J Rianon

Faculty, Staff and Students Publications

Background: The biological mediators for the epidemiologic overlap between osteoporosis and dementia are unclear. We undertook a scoping review of clinical studies to identify genetic and biological factors linked with these degenerative conditions, exploring the mechanisms and pathways connecting both conditions.

Methods: Studies selected (1) involved clinical research investigating genetic factors or biomarkers associated with dementia or osteoporosis, and (2) were published in English in a peer-reviewed journal between July 1993 and March 2025. We searched Medline Ovid, Embase, PsycINFO, the Cochrane Library, the Web of Science databases, Google Scholar, and the reference lists of studies following the guidelines for …

Strengthening Scientific Integrity: Digital Forensics For Biomedical Research Imaging, João Phillipe Cardenuto, Daniel Moreira, Anderson Rocha

Computer Science: Faculty Publications and Other Works

To fight against the increasing misconduct cases in science, this Ph. D. research confronted the challenge of scientific integrity with a pioneering investigation into digital forensic analysis specifically tailored for biomedical images. This work conducted extensive research into key manipulation types–copy-move forgery, image reuse, and AI-generated content–developing novel, fully explainable, and auditable computational detection methods for each. In a commitment to transparency and to promote research to the area, these techniques are provided as open-source resources. Besides the isolated techniques for each type of image forged, a central contribution is the development of an end-to-end system, created through collaboration with …

Antimicrobial Susceptibility Profiles (Mic And Mmc) Against Mycoplasma Gallisepticum And M. Synoviae Isolated From Chicken Farms In Thailand, Kriengwich Limpavithayakul, Alongkorn Amonsin, Nataya Charoenvisal, Arithat Limsatanun, Katanyu Yangsuk, Sumrit Toopiya, Füsun Güngör, Esther Schonewille, Javier Uriarte, Somsak Pakpinyo

The Thai Journal of Veterinary Medicine

Mycoplasma gallisepticum (MG) and M. synoviae (MS) are important pathogens causing significant economic losses in poultry production. Disease prevention and control strategies include vaccination, antimicrobial therapy, and strict biosecurity measures. The present study provides, for the first time, both minimum inhibitory concentration (MIC) and minimum mycoplasmacidal concentration (MMC) values as antimicrobial susceptibility profiles of Thai MG and MS field isolates. This study aimed to evaluate the susceptibility of five MG and ten MS isolates to various antimycoplasma drugs: doxycycline, lincomycin-spectinomycin, tiamulin, tilmicosin, tylosin, and tylvalosin, using a microdilution broth assay. For MG isolates, tilmicosin had the highest mean MIC (12.5 …

Effects Of Maackia Amurensis Seed Lectin (Masl) On Oscc Cell Morphology, Pdpn Expression, Growth, And Motility In A Phase 1 Clinical Trial, Ariel C Yin, Cayla J Holdcraft, Tyler J Hellmig, Eamonn J Brace, David I Suster, Alan J Shienbaum, Dylan Roden, Evelyne Kalyoussef, Ghayoour Mir, Eugenio Capitle, Soly Baredes, Rabie M Shanti, Mika K Kaneko, Yukinari Kato, Hisataka Kobayashi, Aki Furusawa, Mahnaz Fatahzadeh, Gary S Goldberg

Rowan-Virtua School of Osteopathic Medicine Departmental Research

BACKGROUND: Podoplanin (PDPN) has emerged as a functionally relevant biomarker and chemotherapeutic target expressed by OSCC cells. PDPN signaling can directly increase tumor cell invasion and metastasis, and also inhibit host lymphocyte activation and immune response. Accordingly, antibodies and Maackia amurensis seed lectin (MASL) can target the PDPN receptor to inhibit OSCC cell migration and viability. However, the effects of MASL on OSCC cells in oral cancer patients has not yet been reported.

METHODS: We conducted a Phase 1 human clinical trial to examine the effects of a single 100 mg oral dose of MASL on OSCC cell morphology, PDPN …

Stratifying The Population Based On Health Risk: Identification Of Patient Key Health Risk Factors Through Consensus Techniques, Carolina Castagna, Andrew Huff, Aaron Douglas, Phd, Matteo Garofano, Massimo Fabi, Richard W. Hass, Vittorio Maio

College of Population Health Faculty Papers

BACKGROUND: Risk stratification is a population health management approach that classifies patients according to their health risks and projected care needs. This strategy is especially valuable in primary care, where timely interventions for high-risk individuals can lead to better health outcomes, reduced healthcare expenditures, and a more sustainable healthcare system. The goal of this study was to establish expert consensus on the clinical and sociodemographic patient factors that should be incorporated into a primary care risk stratification tool.

METHODS: A multidisciplinary expert panel of 24 healthcare professionals, including primary care providers (PCPs), specialists, and allied health professionals, was convened in …

Genes Encoding Multiple Modulators Of The Immune Response Are Methylated In The Prostate Tumor Microenvironment Of African Americans, Vinay Kumar, Tara Sinta Kartika Jennings, Lucas Ueta, James Nguyen, Liankun Song, Michael Mcclelland, Weiping Chu, Michael Lilly, Michael Ittmann, Patricia Castro, Arash Rezazadeh Kalebasty, Dan Mercola, Omid Yazdanpanah, Xiaolin Zi, Farah Rahmatpanah

Faculty, Staff and Students Publications

Background/Objectives: Prostate cancer (PCa) is diagnosed at an earlier median age, more advanced stage, and has worse clinical outcomes in African American (AA) men compared to European Americans (EA).

Methods: To investigate the role of aberrant DNA methylation in tumor-adjacent stroma (TAS), methyl binding domain sequencing (MBD-seq) was performed on AA (n = 17) and EA (n = 15) PCa patients. This was independently confirmed using the long interspersed nuclear element-1 (LINE-1) assay. Pathway analysis was performed on statistically significantly differentially methylated genes for AA and EA TAS. DNA methylation profiles of primary cultured AA and …