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Articles 27511 - 27540 of 33735
Full-Text Articles in Entire DC Network
High Genetic Diversity Within And Low Differentiation Among Juniperus Excelsa M. Bieb.Populations: Molecular Markers Reveal Their Genetic Structure Patterns, Özay Hasan Evren, Nuray Kaya
High Genetic Diversity Within And Low Differentiation Among Juniperus Excelsa M. Bieb.Populations: Molecular Markers Reveal Their Genetic Structure Patterns, Özay Hasan Evren, Nuray Kaya
Turkish Journal of Botany
J. excelsa M. Bieb forms about 82% of the total juniper forests in Turkey. A total of 456 plant samples belonging to 19 J. excelsa populations were collected to determine the genetic variation of J. excelsa and compare their genetic diversity among populations via simple-sequence repeat (SSR) and intron targeted amplified polymorphism (ITAP) markers. Seven SSR and 132 ITAP loci were polymorphic. The percentage of polymorphism for ITAP loci at the population level ranged from 31.34 to 55.97. Average values of expected heterozygosity, observed heterozygosity, Shannon's information index, Fis, Fst and Nm for SSR loci were 0.616, 0.512, 1.54, 0.124, …
Volvopluteus And Pluteus Section Pluteus (Agaricales: Pluteaceae) In Turkey Based Onmorphological And Molecular Data, Oğuzhan Kaygusuz, İbrahi̇m Türkekul, Henning Knudsen, Nelson Menolli Jr.
Volvopluteus And Pluteus Section Pluteus (Agaricales: Pluteaceae) In Turkey Based Onmorphological And Molecular Data, Oğuzhan Kaygusuz, İbrahi̇m Türkekul, Henning Knudsen, Nelson Menolli Jr.
Turkish Journal of Botany
Pluteus and Volvopluteus are two closely related genera of Pluteaceae that comprise saprotrophic fungi. Although the genera have been well-studied in Europe and North and South America, the diversity of Pluteus, mainly Pluteus sect. Pluteus, and Volvopluteus in Turkey is poorly known due to insufficient morphological descriptions and a lack of DNA sequence data. In this study, the diversity of Pluteus sect. Pluteus and Volvopluteus in Turkey is evaluated by employing both morphological features and phylogenetic approaches. A general phylogeny of Pluteus sect. Pluteus based on sequences of nuc rDNA internal transcribed spacer (ITS1-5.8S-ITS2 = ITS) region is presented and …
Applications Of Crispr/Cas9-Based Genome Editing In The Plant Biology, Yingzhuan Zheng, Qianqian Li, Mingwang Ye, Aie Cehn, Hongyang Wang
Applications Of Crispr/Cas9-Based Genome Editing In The Plant Biology, Yingzhuan Zheng, Qianqian Li, Mingwang Ye, Aie Cehn, Hongyang Wang
Turkish Journal of Botany
Clustered regularly interspaced short palindromic repeats/CRISPR-associated proteins (CRISPR/Cas) is an acquired immune system found in bacteria and archaea that can specifically silence or degrade a foreign single or double strand nucleic acid to protect it from infection. In recent years, the CRISPR/Cas9 system has rapidly been evolved into a genome editing technology, in which the Cas9 endonuclease can be targeted to specific DNA sequences by guide RNAs (gRNAs) that are easily programmable. Due to simplicity, specificity and high efficiency, CRISPR/Cas9 is gradually replacing other gene editing technologies and has been implemented in basic and applied plant sciences to boost yield, …
Traditional Herbal Remedies Used In Kidney Diseases In Turkey: An Overview, Şükran Kültür, Bahar Gürdal, Aynur Sari, Gülay Meli̇koğlu
Traditional Herbal Remedies Used In Kidney Diseases In Turkey: An Overview, Şükran Kültür, Bahar Gürdal, Aynur Sari, Gülay Meli̇koğlu
Turkish Journal of Botany
Ethnobotanical and ethnomedicinal studies have become increasingly recognised as a valuable source of information on the use and possible pharmacological activity of many plant species. There is no study presenting traditional herbal remedies used for kidney diseases in Turkey. The purpose of the paper is to compile herbal remedies used in kidney diseases in Turkey with detailed usage information and chemical constituents. The botanical names, families, and local names; used parts; preparation methods; administration/ dosage; kidney problems and chemical constituents were presented by screening ethnobotanical, ethnomedicinaland phytochemical studies. The most cited plant families, the most cited genera, and the most …
Evaluation Of Bermudagrass [Cynodon (L.) Rich] Accessions With Different Ploidy Levels, Cansu Bülbül, Songül Sever Mutlu, Nedi̇m Mutlu, Osman Gülşen
Evaluation Of Bermudagrass [Cynodon (L.) Rich] Accessions With Different Ploidy Levels, Cansu Bülbül, Songül Sever Mutlu, Nedi̇m Mutlu, Osman Gülşen
Turkish Journal of Botany
Eastern Mediterranean is considered as a center of diversity of
Genetic Structure Of Zannichellia L. Populations According To Mountain Barriers In Iranas Revealed By Issr And Srap Markers, Shabnam Abbasi, Saeed Afsharzadeh, Mehri Dinarvand
Genetic Structure Of Zannichellia L. Populations According To Mountain Barriers In Iranas Revealed By Issr And Srap Markers, Shabnam Abbasi, Saeed Afsharzadeh, Mehri Dinarvand
Turkish Journal of Botany
Zannichellia L. (Potamogetonaceae) is a widespread aquatic genus that is distributed in temperate and subtropical aquatic ecosystems worldwide. Because the biogeographical location of Iran includes mountain ranges and deserts that may cause different habitat types, it was assumed that these Zannichellia populations would be stronger differentiated than observed in Zannichellia from temperate regions. The present study aimed to test whether Z. palustris would demonstrate high levels of genetic differentiation over long distances and across mountain ranges. The genetic structure of the populations of Zannichellia was investigated using inter simple sequence repeats (ISSR) and sequence-related amplified polymorphism (SRAP) as molecular markers. …
A New Species Of Foliicolous Lichenized Fungi From Southwest China: Calopadia Ruiliensissp. Nov., Hai-Xia Wu, Wei-Bin Ren, Xin-Hao Li, Zi-Xiang Yang
A New Species Of Foliicolous Lichenized Fungi From Southwest China: Calopadia Ruiliensissp. Nov., Hai-Xia Wu, Wei-Bin Ren, Xin-Hao Li, Zi-Xiang Yang
Turkish Journal of Botany
Calopadia ruiliensis, found on living leaves in southwest China, is described as a new species, based on morphology and phylogenetic analysis. It is characterized by a foliicolous thallus with yellow greenish to creamy yellow color, rounded apothecia with nonpruinose to thinly pruinose disc, a dark olive-green hypothecium and black-brown subhymenium, and 1-spored asci producing muriform ascospores. Phylogenetic analysis of LSU sequence data shows that the new species clusters in the genus Calopadia with high bootstrap support. The new species is compared with closely related and similar species of Calopadia and a comprehensive description and micrographs are provided.
Taxonomic Monograph Of The Tribe Nigelleae (Ranunculaceae): A Group Including Ancientmedicinal Plants, Ali̇ Aslan Dönmez, Zübeyde Uğurlu Aydin, Emel Oybak Dönmez
Taxonomic Monograph Of The Tribe Nigelleae (Ranunculaceae): A Group Including Ancientmedicinal Plants, Ali̇ Aslan Dönmez, Zübeyde Uğurlu Aydin, Emel Oybak Dönmez
Turkish Journal of Botany
The tribe Nigelleae Schröd. (Ranunculaceae) worldwide distribution has been studied taxonomically, based on morphological, palynological and seed morphological characters, as well as chromosome counts. Extensive field works have been carried out in Turkey, Greece, Iran, Syria, Lebanon, Portugal and in Northern Cyprus. Moreover, the specimens of major herbaria in Turkey, Ukraine, Russia, Syria and Iran as well in Europe have been examined. This study represents the most comprehensive monograph of the tribe based on field work across its nearly entire distributional range, complemented by examination of over 980 specimens from 25 herbaria and our collections with nomenclatural contributions. Eighteen species …
Ecological Assessment Of Burç Reservoir's Surface Water (Turkey) Using Phytoplanktonmetrics And Multivariate Approach, Abuzer Çelekli̇, Gülümser Özpinar
Ecological Assessment Of Burç Reservoir's Surface Water (Turkey) Using Phytoplanktonmetrics And Multivariate Approach, Abuzer Çelekli̇, Gülümser Özpinar
Turkish Journal of Botany
The present study aimed to elucidate relationships between phytoplankton species and stressors using multivariate approaches and assess the environmental condition of Burç Reservoir?s surface water using phytoplankton metrics from September 2018 to August 2019 according to implementations of the Water Framework Directive. Burç Reservoir had a characteristic of a warm monomictic pattern. Phytoplankton functional groups (E, F, J, LO, LM, MP , P, S1 , T, and W1 ) were found in the reservoir. A significant difference was found in total biovolume values changed from 2.28 mm3 /L in November 2018 to 0.51 mm3 /L in February 2019. The first …
Nomenclatural And Taxonomic Notes On Some Stachys Taxa (Lamiaceae), Özal Güner, P. Pablo Ferrer-Gallego
Nomenclatural And Taxonomic Notes On Some Stachys Taxa (Lamiaceae), Özal Güner, P. Pablo Ferrer-Gallego
Turkish Journal of Botany
Stachys glechomifolia (Lamiaceae), previously included under S. mardinensis as a synonym, is resurrected in this work based on extensive field and herbarium studies. In addition to its distribution in Turkey, S. mardinensis has firstly been recorded from Iran. Furthermore, the lectotypes of S. fragillima, S. graveolens, and S. kurdica var. brevidens are designated in this study. An expanded description and distribution map of S. glechomifolia, and some taxonomic notes on S. graveolens, S. fragillima, S. mardinensis, and S. nephrophylla are also reported.
Synthesis Of 7,12-Bis(4-(Di(1h-Pyrrol-2-Yl)Methyl)Phenyl)Benzo[K]Fluoranthene From Anew Dialdehyde As A Novel Fluorometric Bis-Dipyrromethane Derivative, Faride Ranjbari, Salar Hemmati, Mohammad Reza Rashidi
Synthesis Of 7,12-Bis(4-(Di(1h-Pyrrol-2-Yl)Methyl)Phenyl)Benzo[K]Fluoranthene From Anew Dialdehyde As A Novel Fluorometric Bis-Dipyrromethane Derivative, Faride Ranjbari, Salar Hemmati, Mohammad Reza Rashidi
Turkish Journal of Chemistry
Dipyrromethanes are useful mediator structures which can be used as a part of other molecules such as bis-porphyrins and their derivations. Various methods have been developed for their synthesis. This study presents the synthesis of a new bis- dipyrromethane, 7,12-bis(4-(di(1H-pyrrol-2-yl)methyl)phenyl)benzo[k]fluoranthene, using the Lewis acid catalyzed reaction between a new dialdehyde and pyrrole at room temperature. The UV spectroscopic and fluorometric properties of the final product and precursors were determined. The newly synthesized product with desirable UV spectroscopic and fluorometric properties has the potential to be applied as a part of bisporphyrins or it can be used for other purposes in …
Microwave Assisted, Sequential Two-Step, One-Pot Synthesis Of Novel Imidazo[1,2-A]Pyrimidine Containing Tri/Tetrasubstituted Imidazole Derivatives, Tuğba Güngör
Turkish Journal of Chemistry
A series of novel imidazo[1,2-a]pyrimidine containing tri/tetrasubstituted imidazole derivatives (1-10) has been synthesized via sequential two-step, one-pot, multicomponent reaction using imidazo[1,2-a]pyrimidine-2-carbaldehyde, benzil, primary amines, and ammonium acetate catalyzed by p-toluenesulfonic acid under microwave-assisted conditions. The results showed that target compounds can be obtained from a wide range of primary amines bearing different functional groups with moderate to good yields (46%-80%) under optimum reaction conditions. This method provides a green protocol for imidazo[1,2-a]pyrimidine containing tri/ tetrasubstituted imidazole derivatives due to ethyl alcohol as a green solvent, microwave irradiation as a greener heating method and one-pot multicomponent reaction as a green technique. …
Formation And Characterization Of Mechanochemically Generated Free Lignin Radicalsfrom Olive Seeds, Fatma Demi̇r
Formation And Characterization Of Mechanochemically Generated Free Lignin Radicalsfrom Olive Seeds, Fatma Demi̇r
Turkish Journal of Chemistry
In this study, formation and quantification of mechanochemically generated free radicals of lignin were evaluated after the extraction of lignin from olive seeds and detailed lignin characterization was performed. Lignin was extracted from crushed olive seeds as an insoluble solid using Klason method. Isolated lignin was mechanochemically grinded under cryo conditions using Cryomill and particlesizes were determined by using Zeta Sizer, structural changes were followed by XRD and FTIR-ATR; thermal stabilities were tracked by TGA and DSC. In order to enable solubility demanding studies (such as 1H-NMR and GPC), acylation of lignin was accomplished. ESR measurements were completed to prove …
Development Of A Spiramycin Sensor Based On Adsorptive Stripping Linear Sweepvoltammetry And Its Application For The Determination Of Spiramycin In Chicken Eggsamples, Mustafa Ci̇ttan
Turkish Journal of Chemistry
Herein, an adsorptive stripping linear sweep voltammetric technique was described to determine spiramycin, a macrolide antibiotic, using a carboxylic multiwalled glassy carbon electrode modified with carbon nanotubes. The main principle of the analytical methodology proposed was based on the preconcentration of spiramycin by open-circuit accumulation of the macrolide onto the modified electrode surface. As a result of the adsorption affinity of spiramycin to the modified surface, the sensitivity of the glassy carbon electrode was significantly increased for the determination of spiramycin. The electrochemical behavior of spiramycin was evaluated by cyclic voltammetry and the irreversible anodic peak observed was measured as …
Analyzing Differentially Expressed Genes And Pathways Of Bex2-Deficient Mouse Lung Via Rna-Seq, Noor Bahadar, Hanif Ullah, Salah Adlat, Rajiv Kumar Sah, May Zun Zaw Myint, Zin Mar Oo, Fatoumata Binta Bah, Farooq Hayel Nagi, Hsu Htoo, Ahmad Ud Din, Xuechao Feng, Yaowu Zheng
Analyzing Differentially Expressed Genes And Pathways Of Bex2-Deficient Mouse Lung Via Rna-Seq, Noor Bahadar, Hanif Ullah, Salah Adlat, Rajiv Kumar Sah, May Zun Zaw Myint, Zin Mar Oo, Fatoumata Binta Bah, Farooq Hayel Nagi, Hsu Htoo, Ahmad Ud Din, Xuechao Feng, Yaowu Zheng
Turkish Journal of Biology
Bex2 is well known for its role in the nervous system, and is associated with neurological disorders, but its role in the lung's physiology is still not reported. To elucidate the functional role of Bex2 in the lung, we generated a Bex2 knock-out (KO) mouse model using the CRISPR-Cas9 technology and performed transcriptomic analysis. A total of 652 genes were identified as differentially expressed between Bex2-/- and Bex2+/+ mice, out of which 500 were downregulated, while 152 were upregulated genes. Among these DEGs, Ucp1, Myh6, Coxa7a1, Myl3, Ryr2, RNaset2b, Npy, Enob1, Krt5, Myl2, Hba-a2, and Nrob2 are the most prominent …
Identification Of Differentially Expressed Genomic Repeats In Primary Hepatocellular Carcinoma And Their Potential Links To Biological Processes And Survival, Gökhan Karakülah, Ci̇hangi̇r Yandim
Identification Of Differentially Expressed Genomic Repeats In Primary Hepatocellular Carcinoma And Their Potential Links To Biological Processes And Survival, Gökhan Karakülah, Ci̇hangi̇r Yandim
Turkish Journal of Biology
Hepatocellular carcinoma (HCC) is one of the deadliest cancers. Research on HCC so far primarily focused on genes and provided limited information on genomic repeats, which constitute more than half of the human genome and contribute to genomic stability. In line with this, repeat dysregulation was significantly shown to be pathological in various cancers and other diseases. In this study, we aimed to determine the full repeat expression profile of HCC for the first time. We utilised two independent RNA-seq datasets obtained from primary HCC tumours with matched normal tissues of 20 and 17 HCC patients, respectively. We quantified repeat …
Screening Of The Small Molecule Library Of Meinox Enables The Identification Of Anticancer Compounds In Pathologically Distinct Cancers, Aynura Mammadova, Ari̇f Mermer, Fati̇h Kocabaş
Screening Of The Small Molecule Library Of Meinox Enables The Identification Of Anticancer Compounds In Pathologically Distinct Cancers, Aynura Mammadova, Ari̇f Mermer, Fati̇h Kocabaş
Turkish Journal of Biology
Small molecules are widely used for the modulation of the molecular basis of diseases. This makes them the perfect tool for discovering and developing new therapeutics. In this work, we have established a library of small molecules in house and characterized its molecular and druglike properties. We have shown that most small molecules have molecular weights less than 450. They have pharmaceutically relevant cLogP, cLogS, and druglikeness value distributions. In addition, Meinox's small molecule library contained small molecules with polar surface areas that are less than 60 square angstroms, suggesting their potent ability to cross the blood-brain barrier. Meinox's small …
Phylostat: A Web-Based Tool To Analyze Paralogous Clade Divergencein Phylogenetic Trees, Eli̇f Özçeli̇k, Nurdan Kuru, Ogün Adebali̇
Phylostat: A Web-Based Tool To Analyze Paralogous Clade Divergencein Phylogenetic Trees, Eli̇f Özçeli̇k, Nurdan Kuru, Ogün Adebali̇
Turkish Journal of Biology
Phylogenetic trees are useful tools to infer evolutionary relationships between genetic entities. Phylogenetics enables not only evolution-based gene clustering but also the assignment of gene duplication and deletion events to the nodes when coupled with statistical approaches such as bootstrapping. However, extensive gene duplication and deletion events bring along a challenge in interpreting phylogenetic trees and require manual inference. In particular, there has been no robust method of determining whether one of the paralog clades systematically shows higher divergence following the gene duplication event as a sign of functional divergence. Here, we provide Phylostat, a graphical user interface that enables …
Culture Media And Growth Regulators Influence Callus Induction And Plant Regeneration Of Mature Embryos Of Orchardgrass (Dactylis Glomerata L.), Selçuk Kodaz, Kami̇l Hali̇loğlu, Arash Hossein Pour, Murat Aydin
Culture Media And Growth Regulators Influence Callus Induction And Plant Regeneration Of Mature Embryos Of Orchardgrass (Dactylis Glomerata L.), Selçuk Kodaz, Kami̇l Hali̇loğlu, Arash Hossein Pour, Murat Aydin
Turkish Journal of Agriculture and Forestry
To establish an efficient in vitro regeneration protocol for orchardgrass (Dactylis glomerata L.), type of medium, several plant growth regulators and their various concentrations were evaluated in a factorial experiment for callus induction and plant regeneration. Endosperm supported mature embryo were used as explants and optimum response in callus induction was observed on Chu medium with 12 mg/L dicamba (3.6-dichloro-2-methoxybenzoic acid). The highest responding embryogenic callus (15%) was found with Murashige and Skoog medium and 8 mg/L 2.4-D (2,4-dichlorophenoxy acetic acid). The highest regeneration efficiency was achieved on MS medium (17 plantlets) with 8 mg/L 2,4-D. Endosperm-supported mature embryos of …
The Rapid Detection Method Of Chlorophyll Content In Rapeseed Based On Hyperspectral Technology, Hongyuan Tang, Guiping Liao
The Rapid Detection Method Of Chlorophyll Content In Rapeseed Based On Hyperspectral Technology, Hongyuan Tang, Guiping Liao
Turkish Journal of Agriculture and Forestry
The inconsistency of chlorophyll content in rapeseed directly affects the quality of seed, so it is necessary to establish a rapid and nondestructive detection technology of chlorophyll in mature rapeseed. In this paper, the content of chlorophyll in rapeseed samples was determined by ultraviolet-visible spectrophotometry, and the near-infrared spectrum data were collected. The partial least squares regression model of chlorophyll content in rapeseed was established based on hyperspectral technology through first derivative and standard normal variable transformation pretreatment. The results of the cross-test showed that the determination coefficient of the validation set of the prediction model of chlorophyll content in …
Combination Of Classical And Statistical Approaches To Enhance The Fermentation Conditions And Increase The Yield Of Lipopeptide(S) By Pseudomonas Sp. Oxdc12: Its Partial Purification And Determining Antifungal Property, Vivek Chauhan, Vivek Dhiman, Shamsher S. Kanwar
Combination Of Classical And Statistical Approaches To Enhance The Fermentation Conditions And Increase The Yield Of Lipopeptide(S) By Pseudomonas Sp. Oxdc12: Its Partial Purification And Determining Antifungal Property, Vivek Chauhan, Vivek Dhiman, Shamsher S. Kanwar
Turkish Journal of Biology
Around 200 different lipopeptides (LPs) have been identified to date, most of which are produced via Bacillus and Pseudomonas species. The clinical nature of the lipopeptide (LP) has led to a big surge in its research. They show antimicrobial and antitumor activities due to which mass-scale production and purification of LPs are beneficial. Response surface methodology (RSM) approach has emerged as an alternative in the field of computational biology for optimizing the reaction parameters using statistical models. In the present study, Pseudomonas sp. strain OXDC12 was used for production and partial purification of LPs using Thin Layer Chromatography (TLC). The …
The Effects Of Increasing Doses Of Nickel And Lead Applications On Some Oriental Tobacco Varieties, Mahmut Tepeci̇k, Mehmet Eşref İrget
The Effects Of Increasing Doses Of Nickel And Lead Applications On Some Oriental Tobacco Varieties, Mahmut Tepeci̇k, Mehmet Eşref İrget
Turkish Journal of Agriculture and Forestry
Heavy metals are hazardous pollutants for humans, animals and plants, when their threshold concentration exceeds. Tobacco can accumulate higher concentrations of heavy metals, and the genotypic differences of tobacco in heavy metal uptake and their growth responses have not been clearly examined. In this study, the effects of nickel (Ni) and lead (Pb) on phytoremediation capabilities were tested in four local Oriental tobacco cultivars (Basma, Akhisar, Sarıbağlar and Dibek). In two pot experiments, nitrogen (N), phosphorus (P) and potassium (P) were applied in fıxed doses, while Pb and Ni were applied at 4 different doses (10, 50, 100 and 150 …
Analysis Of The Effect Of Reasonable Close Planting On Respiration Characteristics Of Alfalfa(Medicago Sativa L.) Artificial Grassland, Zhuo Luo
Turkish Journal of Agriculture and Forestry
The degree of dense planting affects the respiration characteristics of alfalfa artificial grassland. In the process of alfalfa seed production, high plant and multibranch forage can be obtained by reasonable close planting. Therefore, an analysis method of the effect of reasonable close planting on respiration characteristics of garden alfalfa artificial grassland is put forward. In this method, the density characteristics of alfalfa planting were determined from three aspects of plant horizontal density, vertical density and three-dimensional density. The infrared carbon dioxide gas analyser was used to measure the carbon dioxide flux of the garden. The combined analysis method was constructed …
The Effect Of Weekend Curfews On Epidemics: A Monte Carlo Simulation, Hakan Kaygusuz, Ahmet Ni̇hat Berker
The Effect Of Weekend Curfews On Epidemics: A Monte Carlo Simulation, Hakan Kaygusuz, Ahmet Ni̇hat Berker
Turkish Journal of Biology
The ongoing COVID-19 pandemic is being responded with various methods, applying vaccines, experimental treatment options, total lockdowns or partial curfews. Weekend curfews are among the methods for reducing the number of infected persons, and this method is practically applied in some countries such as Turkey. In this study, the effect of weekend curfews on reducing the spread of a contagious disease, such as COVID-19, is modeled using a Monte Carlo algorithm with a hybrid lattice model. In the simulation setup, a fictional country with three towns and 26,610 citizens were used as a model. Results indicate that applying a weekend …
In Silico Drug Repositioning Against Human Nrp1 To Block Sars-Cov-2 Host Entry, Şeref Gül
In Silico Drug Repositioning Against Human Nrp1 To Block Sars-Cov-2 Host Entry, Şeref Gül
Turkish Journal of Biology
Despite COVID-19 turned into a pandemic, no approved drug for the treatment or globally available vaccine is out yet. In such a global emergency, drug repurposing approach that bypasses a costly and long-time demanding drug discovery process is an effective way in search of finding drugs for the COVID-19 treatment. Recent studies showed that SARS-CoV-2 uses neuropilin-1 (NRP1) for host entry. Here we took advantage of structural information of the NRP1 in complex with C-terminal of spike (S) protein of SARSCoV- 2 to identify drugs that may inhibit NRP1 and S protein interaction. U.S. Food and Drug Administration (FDA) approved …
Binary-Qsar Guided Virtual Screening Of Fda Approved Drugs And Compounds In Clinical Investigation Against Sars-Cov-2 Main Protease, Lalehan Oktay, Ece Erdemoğlu, İlayda Tolu, Yeşi̇m Yumak, Ayşenur Özcan, Eli̇f Acar, Şehri̇ban Büyükkiliç, Alpsu Olkan, Serdar Durdaği
Binary-Qsar Guided Virtual Screening Of Fda Approved Drugs And Compounds In Clinical Investigation Against Sars-Cov-2 Main Protease, Lalehan Oktay, Ece Erdemoğlu, İlayda Tolu, Yeşi̇m Yumak, Ayşenur Özcan, Eli̇f Acar, Şehri̇ban Büyükkiliç, Alpsu Olkan, Serdar Durdaği
Turkish Journal of Biology
With the emergence of the new SARS-CoV-2 virus, drug repurposing studies have gained substantial importance. Combined with the efficacy of recent improvements in ligand- and target-based virtual screening approaches, virtual screening has become faster and more productive than ever. In the current study, an FDA library of approved drugs and compounds under clinical investigation were screened for their antiviral activity using the antiviral therapeutic activity binary QSAR model of the MetaCore/MetaDrug platform. Among 6733-compound collection, we found 370 compounds with a normalized therapeutic activity value greater than a cutoff of 0.75. Only these selected compounds were used for molecular docking …