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2021

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Calculating Probable Theoretical Offspring Genotype In Fruit Flies, Megan Keller Jan 2021

Calculating Probable Theoretical Offspring Genotype In Fruit Flies, Megan Keller

Undergraduate Journal of Mathematical Modeling: One + Two

Being able to calculate an offspring's theoretical genotype is critical in genetic sciences. We calculate the theoretical genotype and phenotype of fruit fly offspring. Using the product rule, we determine the probability for each trait and then for each genotype. In conclusion, we calculate 64 different genotypes that are supposed to be possible, but only 8 phenotypes are possible.

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Evaluating The Improvement In Dna Fingerprinting, Dani Dray Jan 2021

Evaluating The Improvement In Dna Fingerprinting, Dani Dray

Undergraduate Journal of Mathematical Modeling: One + Two

DNA fingerprinting is a forensic technique used to create patterns that are unique to a person’s DNA. Previously, these fingerprints were made from 13 different segments of DNA, but today they are made from the 20 ones. The fundamental principle of counting is used to determine how much of an improvement was made after adding the 7 additional DNA segments. It is found that this addition greatly reduces the likelihood of two people having the same exact fingerprint, therefore improving the accuracy and reliability of DNA fingerprinting.

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Calculating The Probability Of Constitutional Isomers Of Pentane, Mary-Margaret Dare Jan 2021

Calculating The Probability Of Constitutional Isomers Of Pentane, Mary-Margaret Dare

Undergraduate Journal of Mathematical Modeling: One + Two

Depending on the reagent, and orientation of collisions within a chemical reaction, organic molecules can be present as different constitutional isomers of the same molecule. We can analyze the likelihood of getting a mixture of pentane with certain conformers. Based on this, we find that there are 16 potential conformers, but 13 are identical structures, meaning only three are distinct from each other. Using the product rule, we then demonstrate how to go about calculating the probability of specific conformers, including specific identical structures, being present in a mixture, and then we demonstrate that process is strictly within the three …

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Systemic Inequalities For Afro-Brazilians, Teya De Oliveira Jan 2021

Systemic Inequalities For Afro-Brazilians, Teya De Oliveira

Honors Undergraduate Theses

Brazil is commonly viewed as a racial paradise on the world front due to its highly mixed-race population. Compared to the United States and South Africa, race-based discriminatory laws and racially motivated violence in Brazil have been absent. Despite these factors, African descendants in Brazil have been at a socioeconomic disadvantage since the nation's birth. Brazilian anthropologist Gilberto Freyre put forth the racial democracy ideology, stating that anyone can ascend the socioeconomic ladder no matter their race. This thesis opposes the racial democracy theory by exposing the various aspects in which Afro-Brazilians are systemically oppressed. In education, jobs & wages, …

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The Lived Experience Of Chronic Pain: On The Contributions Of Phenomenology In Understanding Chronic Pain Disorders, Riley C. Smith Jan 2021

The Lived Experience Of Chronic Pain: On The Contributions Of Phenomenology In Understanding Chronic Pain Disorders, Riley C. Smith

Honors Undergraduate Theses

Chronic pain disorders are estimated to affect a significant proportion of the global population. These disorders are often debilitating and pose a substantial challenge to the everyday life of those affected. Modern medicine has made great strides in understanding the physiological processes involved in chronic pain. However, chronic pain is more than merely a physiological process. Chronic pain is an embodied mode of being-in-the-world that manifests in multiple aspects of lived experience, from the ability to perform day-to-day tasks to the relationship between body and self. Consequently, it is essential to cultivate a rich appreciation of chronic pain as a …

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Authoring Health Literacy In The Everyday, Sarah Rumsey Jan 2021

Authoring Health Literacy In The Everyday, Sarah Rumsey

Electronic Theses and Dissertations, 2020-2023

My experiences with healthcare providers, which pervade my earliest childhood memories, motivated me to become autonomous in managing my health and wellness. This autoethnographic research explores the literacy activities embedded in everyday lived experiences that informed the process of lamination in composing health literacy which influenced health practices and outcomes. By tracing textual trajectories and examining the process of chronotopic lamination to compose my health literacy across everyday literacy activities this autoethnographic thesis project highlights how nonmedically trained persons can use official and nonofficial sources to create a social and culturally contextualized health literacy. This research calls for recognition of …

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Analysis Of City Of St. Petersburg Comprehensive Plan With Special Reference To Coastal Management Considering Climate Change, Michael F. Johnson Jan 2021

Analysis Of City Of St. Petersburg Comprehensive Plan With Special Reference To Coastal Management Considering Climate Change, Michael F. Johnson

USF St. Petersburg campus Honors Program Theses (Undergraduate)

Land Development and the policy that drives it has long been an important issue in the Tampa Bay Area and by extension the state of Florida. Flooding and hurricanes have had to be considered in the future development of most places in Florida. But as climate change begins to pose a serious, leading to rising sea levels, increasingly powerful hurricanes, coastal erosion, increasing drought, and periods of unusually heavy rain, the role of policy, specifically the state- mandated comprehensive plan, in either mitigating or enhancing the susceptibility of any given area to these threats must be evaluated. This paper reviews …

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What Both Hart And Fuller Got Wrong, Oren Gross Jan 2021

What Both Hart And Fuller Got Wrong, Oren Gross

Articles

No abstract provided.

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Characterization Of Modulation And Coherence In Sensorimotor Rhythms Using Different Electroencephalographic Signal Derivations, Stephen Dundon Jan 2021

Characterization Of Modulation And Coherence In Sensorimotor Rhythms Using Different Electroencephalographic Signal Derivations, Stephen Dundon

Theses and Dissertations--Biomedical Engineering

Electroencephalography (EEG) is a widely used technique for monitoring and analyzing brain activity in experimental, diagnostic, and therapeutic applications. Since EEG is sensitive to noise and artefact sources, referential signals at different locations can be combined in different ways to improve signal quality and better localize cortical activity. Four signal derivations were compared against referential EEG in terms of their ability to measure the alpha rhythm modulation (or reactivity) and spatial coherence associated with an eye closure task: a common average reference (CAR), a local average reference (LAR), a large Laplacian (LL), and a focal Laplacian (FL) estimated using a …

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Productivity And Efficiency Difference Among Kentucky Grain Farms, Ahmed Yahya Hussein Jan 2021

Productivity And Efficiency Difference Among Kentucky Grain Farms, Ahmed Yahya Hussein

Theses and Dissertations--Agricultural Economics

This paper attempts to estimate productivity and efficiency for Kentucky grain farms by applying a two-stage Date Envelopment Analysis (DEA) and DEA-based Malmquist method. The study covers the years 1999-2015. Also, productivity and efficiency testing hypotheses among different farm sizes and years are estimated. In the first step, productivity and efficiency indices are estimated through deterministic DEA. In the second stage, a panel regression is run with exogenous variables to explain the productivity and efficiency variation. In general small farms were found to be the least scale efficient compared to mid-sized and large farms, even though the results show overall …

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Yellowtail Snapper: Human-Ecological Relationships In The South Florida Fishery, Brent Stoffle, Amanda D. Stoltz Jan 2021

Yellowtail Snapper: Human-Ecological Relationships In The South Florida Fishery, Brent Stoffle, Amanda D. Stoltz

Journal of Ecological Anthropology

In 2018 over a period of five months researchers from National Oceanographic and Atmospheric Administration’s (NOAA) Southeast Fisheries Science Center (SEFSC) conducted a study with fishermen and local business owners who participate in the South Florida Yellowtail snapper fishery. Fishermen were asked about changes in their targeting strategies over the last several decades; and they perceive these changes to have altered the health and the biology of the snapper species. The changes are perceived as partially responsible for improving both the overall abundance of Yellowtail and having sped up its the growth and reproductive cycles. This is a case where …

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The Struggle Of Indigenous People Of The Lower Rio Mayo, Northwestern Mexico For Water Resources: An Overview And A Critical Assessment, Arthur D. Murphy, Diana Luque, Angelina Martínez-Yrízar, Alberto Búrquez Montijo Jan 2021

The Struggle Of Indigenous People Of The Lower Rio Mayo, Northwestern Mexico For Water Resources: An Overview And A Critical Assessment, Arthur D. Murphy, Diana Luque, Angelina Martínez-Yrízar, Alberto Búrquez Montijo

Journal of Ecological Anthropology

To irrigate the 6.5 million hectares of land of the Mayo River Valley, Sonora, Mexico uses nearly 77% of its water. Sonora is home to seven indigenous groups, with over 110,000 indigenous people living on their ancestral, though largely reduced, territories. The Mayo River Valley is the ancestral land of the Mayo (Yoreme). The 65,000 Mayo who live along the river provide the region with its cultural identity. However, official plans for river water focus on high yield, high value crops, and urban water use. The result is a hydrological crisis for indigenous people in the river valley. Over 90% …

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Fight Or Flight: The Biology Of An Anxiety Attack, Alesandra “Sasha” Temerte Jan 2021

Fight Or Flight: The Biology Of An Anxiety Attack, Alesandra “Sasha” Temerte

Intertext

No abstract provided.

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Preservation Of Heritage School Buildings In The Philippines : A Case Study Of The Gabaldon Buildings, Inero Ancho, Mark Ponce San Juan Jan 2021

Preservation Of Heritage School Buildings In The Philippines : A Case Study Of The Gabaldon Buildings, Inero Ancho, Mark Ponce San Juan

Journal of Urban Culture Research

This research is an attempt to revisit the Philippines’ Gabaldon school buildings (GSB) in the light of Republic Act 11194. The research offers scrutiny of the law vis-a-vis prospects on practices of preserving and advocating the historical and cultural value of GSB. Using qualitative method of research, this study particularly employs content analysis of RA 11194. The discussion of this paper is clustered into two main sections: The narrative of GSB since its beginning, along with presenting notable details of select edifices which still serving the Philippine education system and an in-depth reading and analysis of RA 11194. It scrutinizes …

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Reference Associate Program At Florida State University: Training Future Librarians, Emily Zoe Mann Jan 2021

Reference Associate Program At Florida State University: Training Future Librarians, Emily Zoe Mann

USF St. Petersburg Campus Faculty Publications

No abstract provided.

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Alcohol-Induced Lysosomal Damage And Suppression Of Lysosome Biogenesis Contribute To Hepatotoxicity In Hiv-Exposed Liver Cells, Moses New-Aaron, Paul G. Thomes, Murali Ganesan, Raghubendra Singh Dagur, Terrence Donohue, Kusum K. Kharbanda, Larisa Y. Poluektova, Natalia A. Osna Jan 2021

Alcohol-Induced Lysosomal Damage And Suppression Of Lysosome Biogenesis Contribute To Hepatotoxicity In Hiv-Exposed Liver Cells, Moses New-Aaron, Paul G. Thomes, Murali Ganesan, Raghubendra Singh Dagur, Terrence Donohue, Kusum K. Kharbanda, Larisa Y. Poluektova, Natalia A. Osna

Journal Articles: Internal Medicine

Although the causes of hepatotoxicity among alcohol-abusing HIV patients are multifactorial, alcohol remains the least explored “second hit” for HIV-related hepatotoxicity. Here, we investigated whether metabolically derived acetaldehyde impairs lysosomes to enhance HIV-induced hepatotoxicity. We exposed Cytochrome P450 2E1 (CYP2E1)-expressing Huh 7.5 (also known as RLW) cells to an acetaldehyde-generating system (AGS) for 24 h. We then infected (or not) the cells with HIV-1ADA then exposed them again to AGS for another 48 h. Lysosome damage was assessed by galectin 3/LAMP1 co-localization and cathepsin leakage. Expression of lysosome biogenesis–transcription factor, TFEB, was measured by its protein levels and by …

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Impact Of Acquiring Childhood Cooking Skills On Adults’ Dietary Behaviors, Suzanne Check Jan 2021

Impact Of Acquiring Childhood Cooking Skills On Adults’ Dietary Behaviors, Suzanne Check

Graduate Research Theses & Dissertations

The ability to cook and prepare foods from fresh ingredients is a necessary life skill to improve overall diet quality and to prevent or reduce the risk of chronic diseases. Limited research exists on the appropriate time to develop these skills to have a long-term impact on diet quality and health. The primary objective of this study was to determine whether the age of learning cooking skills promotes higher cooking confidence and diet quality during adulthood. In addition, the study investigated the impact of learning cooking skills from various sources on diet quality and cooking confidence in adulthood. A cross-sectional …

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Usf Libraries Libguides Task Force Report 2020-2021, Usf Libraries Jan 2021

Usf Libraries Libguides Task Force Report 2020-2021, Usf Libraries

All Assessment Data

No abstract provided.

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Laser Powder Bed Fusion Of Ti6al4v-Xcu: Process Parameters, Thywill Ccphas Dzogbewu Jan 2021

Laser Powder Bed Fusion Of Ti6al4v-Xcu: Process Parameters, Thywill Ccphas Dzogbewu

Journal of Metals, Materials and Minerals

The original intent of coating biomedical and surgical devices surface with antibacterial agents is to prevent infections. However, the difference in the material properties between the biomedical devices and the coating materials causes the coating material to spall from the biomedical devices. To address the situation, the current research focused on investigating the possibility of using laser powder bed fusion process a subset of additive manufacturing technology to in situ alloy 1 at% Cu with Ti6Al4V. In situ alloying 1 at% Cu with Ti6Al4V would lead to the production of medical and surgical devices with inbuilt antibacterial property. To determine …

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Perfluoroalkyl And Polyfluoroalkyl Substances: Using Law And Policy To Address These Environmental Health Hazards In The United States, Jennifer Black, Amanda Moreland, Montrece Mcneill Ransom, Emely Sanchez Jan 2021

Perfluoroalkyl And Polyfluoroalkyl Substances: Using Law And Policy To Address These Environmental Health Hazards In The United States, Jennifer Black, Amanda Moreland, Montrece Mcneill Ransom, Emely Sanchez

Health Matrix: The Journal of Law-Medicine

No abstract provided.

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Understanding Structural Malleability Of The Sars-Cov-2 Proteins And Their Relation To The Comorbidities, Sagnik Sen, Ashmita Dey, Sanghamitra Bandyopadhyay, Ujjwal Maulik, Vladimir Uversky Jan 2021

Understanding Structural Malleability Of The Sars-Cov-2 Proteins And Their Relation To The Comorbidities, Sagnik Sen, Ashmita Dey, Sanghamitra Bandyopadhyay, Ujjwal Maulik, Vladimir Uversky

Molecular Medicine Faculty Publications

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a causative agent of the coronavirus disease (CoVID-19), is a part of the β-coronaviridae family. In comparison with two other members of this family of coronaviruses infecting humans (SARS-CoV and Middle East Respiratory Syndrome (MERS) CoV), SARS-CoV-2 showed the most severe effects on the entire Earth population causing world-wide CoVID-19 pandemic. SARS-CoV-2 contains five major protein classes, such as four structural proteins (Nucleocapsid (N), Membrane (M), Envelop (E), and Spike Glycoprotein (S)) and Replicase polyproteins (R), which are synthesized as two polyproteins (ORF1a and ORF1ab) that are subsequently processed into 12 nonstructural proteins …

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Natural Resources To Control Covid-19: Could Lactoferrin Amend Sars-Cov-2 Infectivity?, Ehab H. Mattar, Fatma Elrashdy, Hussein A. Almehdar, Vladimir N. Uversky, Elrashdy M. Redwan Jan 2021

Natural Resources To Control Covid-19: Could Lactoferrin Amend Sars-Cov-2 Infectivity?, Ehab H. Mattar, Fatma Elrashdy, Hussein A. Almehdar, Vladimir N. Uversky, Elrashdy M. Redwan

Molecular Medicine Faculty Publications

The world population is still facing the second wave of the COVID-19 pandemic. Such a challenge requires complicated tools to control, namely vaccines, effective cures, and complementary agents. Here we present one candidate for the role of an effective cure and/or complementary agent: lactoferrin. It is the cross-talking mediator between many organs/cellular systems in the body. It serves as a physiological, immunological, and anti-microbial barrier, and acts as a regulator molecule. Furthermore, lactoferrin has receptors on most tissues cells, and is a rich source for bioactive peptides, particularly in the digestive system. In the past months, in vitro and in …

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Networks Of Networks: An Essay On Multi-Level Biological Organization, Vladimir N. Uversky, Alessandro Giuliani Jan 2021

Networks Of Networks: An Essay On Multi-Level Biological Organization, Vladimir N. Uversky, Alessandro Giuliani

Molecular Medicine Faculty Publications

The multi-level organization of nature is self-evident: proteins do interact among them to give rise to an organized metabolism, while in the same time each protein (a single node of such interaction network) is itself a network of interacting amino-acid residues allowing coordinated motion of the macromolecule and systemic effect as allosteric behavior. Similar pictures can be drawn for structure and function of cells, organs, tissues, and ecological systems. The majority of biologists are used to think that causally relevant events originate from the lower level (the molecular one) in the form of perturbations, that “climb up” the hierarchy reaching …

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On The Prevalence And Potential Functionality Of An Intrinsic Disorder In The Mers-Cov Proteome, Manal A. Alshehri, Manee M. Manee, Fahad H. Alqahtani, Badr M. Al-Shomrani, Vladimir N. Uversky Jan 2021

On The Prevalence And Potential Functionality Of An Intrinsic Disorder In The Mers-Cov Proteome, Manal A. Alshehri, Manee M. Manee, Fahad H. Alqahtani, Badr M. Al-Shomrani, Vladimir N. Uversky

Molecular Medicine Faculty Publications

Middle East respiratory syndrome is a severe respiratory illness caused by an infectious coronavirus. This virus is associated with a high mortality rate, but there is as of yet no effective vaccine or antibody available for human immunity/treatment. Drug design relies on understanding the 3D structures of viral proteins; however, arriving at such understanding is difficult for intrinsically disordered proteins, whose disorder-dependent functions are key to the virus’s biology. Disorder is suggested to provide viral proteins with highly flexible structures and diverse functions that are utilized when invading host organisms and adjusting to new habitats. To date, the functional roles …

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Baicalein Inhibits Heparin-Induced Tau Aggregation By Initializing Non-Toxic Tau Oligomer Formation, Shweta Kishor Sonawane, Vladimir N. Uversky, Subashchandrabose Chinnathambi Jan 2021

Baicalein Inhibits Heparin-Induced Tau Aggregation By Initializing Non-Toxic Tau Oligomer Formation, Shweta Kishor Sonawane, Vladimir N. Uversky, Subashchandrabose Chinnathambi

Molecular Medicine Faculty Publications

Background: Amyloid aggregate deposition is the key feature of Alzheimer’s disease. The proteinaceous aggregates found in the afflicted brain are the intra-neuronal neurofibrillary tangles formed by the microtubule-associated protein Tau and extracellular deposits, senile plaques, of amyloid beta (Aβ) peptide proteolytically derived from the amyloid precursor protein. Accumulation of these aggregates has manifestations in the later stages of the disease, such as memory loss and cognitive inabilities originating from the neuronal dysfunction, neurodegeneration, and brain atrophy. Treatment of this disease at the late stages is difficult, and many clinical trials have failed. Hence, the goal is to find means capable …

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Biomolecules From Different Angles, Vladimir N. Uversky Jan 2021

Biomolecules From Different Angles, Vladimir N. Uversky

Molecular Medicine Faculty Publications

No abstract provided.

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Targeting Autophagy In Ischemic Stroke: From Molecular Mechanisms To Clinical Therapeutics, Amir Ajoolabady, Shuyi Wang, Guido Kroemer, Josef M. Penninger, Vladimir N. Uversky, Domenico Pratico, Nils Henninger, Russel J. Reiter, Askiel Bruno, Kaumudi Joshipura, Hamid Aslkhodapasandhokmabad, Daniel J. Klionsky, Jun Ren Jan 2021

Targeting Autophagy In Ischemic Stroke: From Molecular Mechanisms To Clinical Therapeutics, Amir Ajoolabady, Shuyi Wang, Guido Kroemer, Josef M. Penninger, Vladimir N. Uversky, Domenico Pratico, Nils Henninger, Russel J. Reiter, Askiel Bruno, Kaumudi Joshipura, Hamid Aslkhodapasandhokmabad, Daniel J. Klionsky, Jun Ren

Molecular Medicine Faculty Publications

Stroke constitutes the second leading cause of death and a major cause of disability worldwide. Stroke is normally classified as either ischemic or hemorrhagic stroke (HS) although 87% of cases belong to ischemic nature. Approximately 700,000 individuals suffer an ischemic stroke (IS) in the US each year. Recent evidence has denoted a rather pivotal role for defective macroautophagy/autophagy in the pathogenesis of IS. Cellular response to stroke includes autophagy as an adaptive mechanism that alleviates cellular stresses by removing long-lived or damaged organelles, protein aggregates, and surplus cellular components via the autophagosome-lysosomal degradation process. In this context, autophagy functions as …

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Simple And Efficient Protocol For Immunoglobulin Y Purification From Chicken Egg Yolk, Elrashdy M. Redwan, Abdullah A. Aljadawi, Vladimir N. Uversky Jan 2021

Simple And Efficient Protocol For Immunoglobulin Y Purification From Chicken Egg Yolk, Elrashdy M. Redwan, Abdullah A. Aljadawi, Vladimir N. Uversky

Molecular Medicine Faculty Publications

Besides being a common food component broadly consumed worldwide, egg yolk immunoglobulin Y (IgY) has essential therapeutic potentials. In fact, in a time of ever-increasing risk of antibiotic resistance, it is crucial to find new ways to battle infection, and oral administration of preformed specific antibodies represents one of the most attractive approaches against infection. Infectious diseases of bacterial and viral origin in humans and animals can be controlled and passively cured by orally applied IgYs isolated from chicken egg yolks. Despite multiple obvious advantages of oral administration of IgY, harvesting IgY from egg yolk in a pure form is …

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Structural Modeling Of The Treponema Pallidum Outer Membrane Protein Repertoire: A Road Map For Deconvolution Of Syphilis Pathogenesis And Development Of A Syphilis Vaccine, Kelly L. Hawley, Jairo M. Montezuma-Rusca, Kristina N. Delgado, Navreeta Singh, Vladimir N. Uversky, Melissa J. Caimano, Justin D. Radolf, Amit Luthra Jan 2021

Structural Modeling Of The Treponema Pallidum Outer Membrane Protein Repertoire: A Road Map For Deconvolution Of Syphilis Pathogenesis And Development Of A Syphilis Vaccine, Kelly L. Hawley, Jairo M. Montezuma-Rusca, Kristina N. Delgado, Navreeta Singh, Vladimir N. Uversky, Melissa J. Caimano, Justin D. Radolf, Amit Luthra

Molecular Medicine Faculty Publications

Treponema pallidum, an obligate human pathogen, has an outer membrane (OM) whose physical properties, ultrastructure, and composition differ markedly from those of phylogenetically distant Gram-negative bacteria. We developed structural models for the outer membrane protein (OMP) repertoire (OMPeome) of T. pallidum Nichols using solved Gram-negative structures, computational tools, and small-angle X-ray scattering (SAXS) of selected recombinant periplasmic domains. The T. pallidum “OMPeome” harbors two “stand-alone” proteins (BamA and LptD) involved in OM biogenesis and four paralogous families involved in the influx/efflux of small molecules: 8-stranded β-barrels, long-chain-fatty-acid transporters (FadLs), OM factors (OMFs) for efflux pumps, and T. pallidum repeat proteins …

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Serotonin Promotes Serum Albumin Interaction With The Monomeric Amyloid Β Peptide, Ekaterina A. Litus, Alexei S. Kazakov, Eugenia I. Deryusheva, Ekaterina L. Nemashkalova, Marina P. Shevelyova, Aliya A. Nazipova, Maria E. Permyakova, Elena V. Raznikova, Vladimir N. Uversky, Sergei E. Permyakov Jan 2021

Serotonin Promotes Serum Albumin Interaction With The Monomeric Amyloid Β Peptide, Ekaterina A. Litus, Alexei S. Kazakov, Eugenia I. Deryusheva, Ekaterina L. Nemashkalova, Marina P. Shevelyova, Aliya A. Nazipova, Maria E. Permyakova, Elena V. Raznikova, Vladimir N. Uversky, Sergei E. Permyakov

Molecular Medicine Faculty Publications

Prevention of amyloid β peptide (Aβ) deposition via facilitation of Aβ binding to its natural depot, human serum albumin (HSA), is a promising approach to preclude Alzheimer’s disease (AD) onset and progression. Previously, we demonstrated the ability of natural HSA ligands, fatty acids, to improve the affinity of this protein to monomeric Aβ by a factor of 3 (BBRC, 510(2), 248–253). Using plasmon resonance spectroscopy, we show here that another HSA ligand related to AD pathogenesis, serotonin (SRO), increases the affinity of the Aβ monomer to HSA by a factor of 7/17 for Aβ40/Aβ42, respectively. Meanwhile, the structurally homologous SRO …

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