Digital Commons Network^™

Legality And Considerations For Healthcare Chief Information Officers Migrating To The Public Cloud, Melissa Petak

MUSC Theses and Dissertations

There are many advantages for healthcare organizations to use the public cloud for storage/computing. However, moving data outside of the organization’s physical boundaries implies lost or reduced control and greater reliance on Cloud Service Providers (CSP) in determining where the data is stored and how it is secured. When that data is sensitive healthcare data and at high-risk for cyber/national security violations as well as, belonging to U.S. citizens, the need for careful planning and legal compliance increases sharply. The following study evaluates the legality and considerations of public cloud use for healthcare Chief Information Officers (CIO) and the need …

Uncovering The ‘Hidden Fibrosis’ Of Pediatric Congenital Aortic Valve Stenosis Via Targeted Mass Spectrometry Approaches, Cassandra Lucille Clift

MUSC Theses and Dissertations

Congenital aortic valve stenosis (CAVS) affects up to 10% of the world population without medical therapies to treat the disease. New molecular targets are continually being sought that can halt CAVS progression, particularly in pediatric patients where bioengineered solutions are not ideal. Collagen deregulation is a hallmark of pediatric CAVS yet remains mostly undefined. Here, histological studies were paired with high resolution accurate mass (HRAM) collagen-targeting proteomics and imaging mass spectrometry to investigate collagen fiber production with localized collagen regulation associated with human AV development and pediatric end-stage CAVS (pCAVS). Histological studies identified collagen fiber realignment and unique regions of …

A Small Molecule Screen To Identify A Potential Treatment For Mtdps3, Connor Jade Jocelyn Graham

MUSC Theses and Dissertations

Mitochondrial DNA Depletion Syndrome 3 (MTDPS3) is the most common mitochondrial DNA (mtDNA) depletion syndrome. MTDPS3 is an autosomal recessive disorder caused by a mutation in the deoxyguanosine kinase (DGUOK) gene in which a reduction in mtDNA nucleotides results in decreased levels of Adenosine Triphosphate (ATP). The DGUOK phenotypes vary; however, liver dysfunction tends to be consistent for all pediatric patients. Liver transplants can be beneficial; however, it’s only a palliative treatment at best, and the affected population rarely reaches adulthood. This thesis describes a high-throughput drug screen to identify a potential therapy for MTDPS3. MTDPS3 mutant hepatocytes derived from …

The Roles Of Gsk3 And Reelin In The Modulation Of Behavioral Phenotypes Related To Bipolar Disorder: Implications For The Etiology And Treatment Of Neuropsychiatric Disorders, Angel Sherpa

Pitzer Senior Theses

Deficiency of Reelin, an extracellular glycoprotein, and overactivity of GSK3, a kinase downstream of Reelin, in the brain have been associated with bipolar disorder (BD). Overexpression of Reelin inhibits GSK3 activity by phosphorylation. However, it is unclear if the inhibition of GSK3 in the forebrain is a crucial element of Reelin signaling modulating bipolar-like behaviors. To fill this gap in our understanding, my first experiment proposes to examine if Reelin-deficient mice with reduced activity of GSK3 exhibit BD-like behaviors. If inhibition of GSK3 is indeed a crucial element of Reelin signaling modulating BD-like behaviors, then Reelin-deficient mice with decreased activity …

Obesity And The Hippocampus: How Diet-Induced Insulin Resistance Contributes To Memory Impairment, Luke S. Watson

MUSC Theses and Dissertations

Over 93 million Americans are obese, a condition which also increases the risk for developing neurocognitive disorders such as Alzheimer’s disease. Insulin is critically important for maintaining homeostasis in the central nervous system, but in order to play this role it has to be transported in from the periphery. Interestingly, peripheral hyperinsulinemia is linked to reduced central nervous system insulin. The overarching hypothesis of this dissertation is that chronic hyperinsulinemia reduces hippocampal insulin transport, thereby dysregulating insulin receptor signaling proteins and leading to memory impairment. In order to test this hypothesis, we assessed the high-fat diet mouse model in two …

Age:Rage Signaling Pathway As A Target In Neuroendocrine Prostate Cancer, De'marcus Deon Woolfork

MUSC Theses and Dissertations

Prostate cancer, a disease of aging, is the second leading cause of male cancer deaths in the United States and is canonically controlled by androgen expression which is treated with androgen deprivation therapy (ADT) that suppress androgen production, androgen receptor function, or both. The androgen receptor (AR) plays a critical role in cancer development, progression, and therapy response. Recurring cancer cells undergo cellular reprogramming, adopting alternative mechanisms of survival, entering an androgen receptor-independent state, and are then subcategorized as Castration Resistant Prostate Cancers (CRPC). A process known as neuroendocrine differentiation, has been shown to be upregulated in response to ADT. …

Only With Thine Eyes, Morgan Mcivor Bowser

Masters Essays

No abstract provided.

Effectiveness Of Group Work Contracts To Facilitate Collaborative Group Learning And Reduce Anxiety In Traditional Face-To-Face Lecture And Online Distance Education Course Formats, Sydney F. Brannen, David Beauchamp, Nadia M. Cartwright, Danyelle M. Liddle, Justine M. Tishinsky, Genevieve Newton, Jennifer M. Monk

International Journal for the Scholarship of Teaching & Learning

Group work (GW) in undergraduate education facilitates the development of communication and collaborative skills. However, dysfunctional and inequitable group dynamics can have adverse effects, leading to increased anxiety. This research sought to determine the effectiveness of a Group Work Contract to facilitate the GW process in the face-to-face (n=168) and online (n=105) formats of a third year nutritional science course. Changes in students’ attitudes and approaches to GW were assessed before (semester week 4) and after (semester week 12) completion of the contract and assignment via online surveys. The results in both course formats were similar, wherein the Group Work …

Development And Use Of Open Educational Resources In Research Methods For Psychology, Stephanie Da Silva Phd, Katherine White

International Journal for the Scholarship of Teaching & Learning

Research methods course(s), a standard in psychology programs, often use multiple textbooks to address conceptual and data-analytic information. This study involved transitioning from traditional textbooks to open educational resources in a research methods course. Two psychology instructors, each offering course sections, identified open-access textbooks that aligned with course learning objectives and developed instructional materials to accompany those textbooks. All materials were organized publicly in an institutional subject guide. We compared students’ grades, pretest-posttest scores, and survey reports of resource use and evaluation in a spring semester, when traditional/costly textbooks were used, to the following fall semester, when no-cost textbooks were …

Negative Regulatory Factors In Tombusvirus Replication: Known Proteins, Novel Roles, Paulina Alatriste González

Theses and Dissertations--Plant Pathology

Although host cells are a rather rich source for co-opted host factors, lipids and metabolites, positive stranded RNA viruses vastly rewire cellular pathways and remodel cellular membranes to support viral replication. To accomplish such major changes, these viruses depend on the availability of different host factors and the ability to readily assemble viral replication organelles (VROs). Genome-wide screens and proteomics approaches with Tomato Bushy Stunt Virus (TBSV) in a yeast model host indicated that tombusviruses rely on the cellular cytoskeleton to reorganize the cellular environment of their hosts. Using temperature-sensitive (ts) mutants of beta and gamma-tubulin proteins and pharmacological inhibitors, …

Learning And Memory, Michael A. Yassa, Thomas Wolbers, Hiroyuki Okuno, Ashok Hegde, Peter K. Giese, Oliver Stork

Faculty and Staff Works

The field of learning and memory has evolved rapidly over the last fifty years. Technological advances have made it possible to observe and record from a large number of neurons simultaneously, manipulate cellular activity to influence regional dynamics, visualize whole brain structure and function with unprecedented resolution, and create artificial intelligence that is capable of complex problem solving. With new technologies, the nature of the questions the field is able to address has also evolved. The 2018 International Conference on Learning and Memory (#LEARNMEM2018) is held on April 18-22, 2018 to celebrate the field’s accomplishments and chart the path for …

Investigating The Effects Of Nitrogen Deposition And Substrates On The Microbiome And Mycobiome Of The Millipede Cherokia Georgiana Georgiana (Diplopoda: Polydesmida), Shawn P. Brown, Matthew Brogden, Christina Cortes, Avery E. Tucker, Allison Rick Vandevoort, Bruce A. Snyder

Faculty and Staff Works

Millipedes are ubiquitous soil invertebrates that play major roles in physical and chemical processes in soil. Despite their importance to soil ecology and their presumed interactions with soil microorganisms, little is known about how millipedes influence and are influenced by soil microbes. Furthermore, it is not fully understood how these millipede-microbe interactions are influenced by available soil nitrogen, which is predicted to increase over the foreseeable future with increased anthropogenic production. Here, using the millipede Cherokia georgiana georgiana as a model and using a manipulative mesocosm and metabarcoding approach, we examine (1) the impacts of millipedes on soil microbial communities …

Ic025: Marianne Marcus, Transcript, University Of Texas Health Science Center At Houston. School Of Nursing

Cizik School of Nursing 50th Anniversary

Transcript of the oral history interview with Marianne Marcus. See more at University of Texas School of Nursing records and its finding aid.

Oil And Canvas Art: Recovery And Analysis Of Unidentified Remains Recovered 2004, Dan Magelinski

Spectrum

No abstract provided.

Materializing And Embodying Sex And Gender: Interpreting Gender And Sex Variance In Iron Age Pre-Roman And Roman Britain Mortuary Contexts, Morgan Martin

Spectrum

No abstract provided.

Embodying Power And Agency In Ancient Egypt: Manifestations Of The Self And Society Through Artifacts And Religious Beliefs, Shannon Mckelvey

Spectrum

No abstract provided.

Was New York City A Source Of Global Sars-Cov-2 Spread?, Cole Jensen

Public Health Theses

Coronavirus disease 2019 (COVID-19) was first diagnosed in the United States on January 15, 2020, in the state of Washington. Shortly after that, on February 29, 2020, the first case of COVID-19 was reported in New York City. From January 2020 through July 2020, there were 223,107 cases of COVID-19 that led to 18,787 COVID-19 related deaths in New York City alone. During this time, many left New York City to avoid contracting the virus or to return home. This travel seeded much of the transmission within the United States. We aimed to identify any international transmission of severe acute …

New Insights On The Role Of The Mesenchymal-Hematopoietic Stem Cell Axis In Autologous And Allogeneic Hematopoiesis., Tatiana D. Zorina

College of Health Professions Faculty Papers

Cytoreductive protocols are integral both as conditioning regimens for bone marrow (BM) transplantation and as part of therapies for malignancies, but their associated comorbidities represent a long-standing clinical problem. In particular, they cause myeloablation that debilitates the physiological role of mesenchymal stem and precursor cells (MSPCs) in sustaining hematopoiesis. This review addresses the damaging impact of cytoreductive regimens on MSPCs. In addition, it discusses prospects for alleviating the resulting iatrogenic comorbidities. New insights into the structural and functional dynamics of hematopoietic stem cell (HSC) niches reveal the existence of "empty" niches and the ability of the donor-derived healthy HSCs to …

2021 Nebraska Beef Cattle Report

Nebraska Beef Cattle Reports

Cow-Calf Nutrition and Management: Metabolic Profile Associated with Pre-Breeding Puberty Status in Range Beef Heifers 5 • Milk Production Impacts on Cow Reproductive and Calf Growth Performance 8 • Genetic Selection Tools: Using Pooling to Capture Commercial Data for Inclusion in Genetic Evaluations 11 • Categorization of Birth Weight Phenotypes for Inclusion in Genetic Evaluations Using a Deep Neural Network 14 • Genetic Parameter Estimates for Age at Slaughter and Days to Finish in a Multibreed Population 16

Growing Calf and Yearling Management: Effects of Monensin and Protein Type on Performance of Yearling Steers Grazing Smooth Bromegrass Pastures 18 • …

Genetic Parameter Estimates For Age At Slaughter And Days To Finish In A Multibreed Population, Lindsay R. Upperman, Larry A. Kuehn, Matthew L. Spangler

Nebraska Beef Cattle Reports

No abstract provided.

Metabolomic Profile Associated With Pre-Breeding Puberty Status In Range Beef Heifers, Joslyn K. Beard, Waseem Abbas, J. A. Musgrave, R. Funston, Samodha C. Fernando, Travis Mulliniks

Nebraska Beef Cattle Reports

Summary with Implications

A 4-yr study utilizing heifers from March and May calving herds collected serum samples prior to breeding to determine puberty status. Serum samples were used for Metabolomics analysis to investigate differences related to circulating serum metabolites in pubertal and non-pubertal heifers. Metabolomics, which is a shotgun approach analysis of a large number of small metabolites, is an emerging technology that can provide a more robust analysis of metabolism. No differences were observed in heifer ADG, pregnancy rate, or the percentage that calved within the first 21 d between heifers classified as pubertal and non-pubertal at the start …

Perceptions Of Barriers And Benefits Of Manure Use In Cropping Systems, Richard Koelsch, Daniel Andersen, Erin Cortus, Leslie Johnson, Amy Schmidt, Siok A. Siek, Melissa Wilson

Nebraska Beef Cattle Reports

Animal agriculture is tasked with recycling the nitrogen and phosphorus in manures in an environmentally sound manner, typically as a soil fertility amendment, which often requires voluntary transfer of manures to crop farms on which there may be little or no history of manure use. # e ability of manure to compete with commercially available fertilizers is essential for this transfer. A survey was conducted of farmers’ and their advisors’ perceptions of the benefits and barriers to manure use in crops. There exists a strong recognition of manure’s agronomic, yield, and soil health benefits. However, many challenges associated with manure …

Predicting Nitrogen And Phosphorous Flows In Beef Open Lots, Megan N. Homolka, Galen E. Erickson, Richard K. Koelsch

Nebraska Beef Cattle Reports

Manure collected from open lot animal housing systems experiences variability due to weather conditions, management of beef cattle and pens, and other factors resulting in substantial changes in manure characteristics. Data from 15 winter and summer periods at the beef feedlot at Eastern Nebraska Research and Extension Center including 416 independent pen measurements, were summarized for nutrient mass balance, and then used to determine sources of variability impacting nitrogen and phosphorous. Understanding variability is important to regulated manure nutrient planning processes. The results of this review suggest significant challenge associated with planning based upon standard values for estimating manure characteristics. …

Transforming Manure And Cedar Mulch From “Waste” To “Worth”, Karla Melgar, Agustin Olivo, Richard Koelsch, Larry Howard, Gary Lesoing, Aaron Nygren, Randy Saner, Amy D. Timmerman, Troy Walz, Todd Whitney, Amy Schmidt

Nebraska Beef Cattle Reports

In nearly every production environment, there are opportunities to capture profits if waste streams can be further processed or enhanced to create “value added” products. Animal feeding operations in Nebraska generate significant amounts of manure that are considered as a “waste” product. Additionally, Eastern red cedar (Juniperus virginiana) encroachment into grazing land has become an economic and ecological threat, reducing forage production, fragmenting wildlife habitats, and increasing the risk and severity of wild fires. Value- added uses for cedar woodchips are being sought by the Nebraska Forest Service and other agencies to promote tree management by landowners. Using manure and …

Using Coal Char From Sugar Production In Cattle Manure Management, Bijesh Maharjan, K. H. Jenkins Pas

Nebraska Beef Cattle Reports

Application of coal char, a coal combustion residue from the sugar factory in Scottsbluff, NE (containing up to 30 % C by weight), was evaluated as a nitrogen (N) loss mitigation tool for feedlot manure in three experiments. In experiment 1, when char was added to piled manure previously removed from feedlot pens, N loss potential was reduced (44% vs. 68% in the control). In experiment 2, manure was collected fresh from the animal, from the pen surface with cattle still in the pen, and from a pile removed from the pen. Char was mixed with these samples in replicated …

Evaluation Of Wheat Blended With Corn In Finishing Diets Containing Wet Distillers Grains, C A. Coulson, B M. Boyd, B B. Conroy, Galen E. Erickson

Nebraska Beef Cattle Reports

An experiment was conducted to evaluate the effect of grain type and wet distillers grains inclusion on finishing cattle performance and carcass characteristics. It was hypothesized that a greater inclusion of wet distillers grains would help mitigate acidosis previously observed with feeding wheat. Treatments were designed as a 2 × 2 factorial arrangement, with the first factor as grain type at either 100% dry rolled corn or a 50:50 blend of dry- rolled wheat and dry rolled corn, and the second factor as wet distillers grains plus solubles (WDGS) inclusion at either 12 or 30% of diet dry matter. There …

Growing Calf Intake Of Hay Or Crop Residue Based Diets, Aksel Wiseman, Andrea K. Watson, Rick Stock, Terry Klopfenstein

Nebraska Beef Cattle Reports

It is important to know or predict feed intake by growing calves on forage- based diets in order to balance these diets for nutrients such as energy and protein. Several growing calf studies with forage- based diets were summarized. ! ese studies evaluated the use of crop residue as a substitute for conventional forages, primarily grass hay. Calves gained about 1.8 lb/day for all forage- based diets. Calves consumed 2.6% of body weight daily when fed hay- based diets, but those fed residue with distillers grains diets consumed only 1.6% of body weight. However, when feeding the residue with distillers …

Peer Victimization And Experiences Of Violence At School And At Home Among School Age Children With Disabilities In Pakistan And Afghanistan, Rozina Somani, Julienne Corboz, Rozina Karmaliani, Esnat D. Chirwa, Judith Mcfarlane, Hussain Maqbool Ahmed Khuwaja, Nargis Asad, Yasmeen Hassan Somani, Ingrid Van Der Heijden, Rachel Jewke

School of Nursing & Midwifery

Background: Children with disabilities are more likely to experience violence or injury at school and at home, but there is little evidence from Central Asia.
Objective: To describe the prevalence of disability and associations with peer violence perpetration and victimization, depression, corporal punishment, school performance and school attendance, among middle school children in Pakistan and Afghanistan.
Method: This is a secondary analysis of data gathered in the course of evaluations of interventions to prevent peer violence conducted in Pakistan and Afghanistan as part of the 'What Works to Prevent Violence against Women and Girls Global Programme'. In …

Effectiveness Of Standard Precautions In The Prevention Of Covid-19, Tazeen Saeed Ali, Shah Zeb, Asghar Ali, Zahir Munir, Sumia Andleeb Abbasi

School of Nursing & Midwifery

Background: COVID-19 is the novel pandemic that has caused exponential deaths worldwide and damaged health care systems of developed as well as developing regions. Many of the HCWs across the countries are getting affected by this infection and losing their lives.
Aims: The aim of this study was to investigate the level of compliance with SPs for the prevention of COVID-19 transmission among HCWs and identify its associated factors.
Methods: An analytical cross sectional study was conducted on 877 HCWs in nine different tertiary care hospitals of Sindh. HCWs were retrieved using universal sampling. Data was collected using self-reporting questionnaire. …

An Innovation In Flipped Class Room: A Teaching Model To Facilitate Synchronous And Asynchronous Learning During A Pandemic, Rehana Rehman, Syeda Sadia Fatima

Department of Biological & Biomedical Sciences

Objective: To conduct an on line Flipped Class Room (FCR) to facilitate synchronous (in class activity) and asynchronous learning [Virtual Learning Environment (VLE)] and acquire feedback of the learning experience from medical students at Aga Khan University.
Methods: This interventional study was conducted with year II students undergoing Endocrine Reproduction Module at the Aga Khan University during April 13 to May 22, 2020. Pre reading material and pretest was shared with the students via Virtual Learning Environment (VLE) one week before the class. Microsoft Teams was used to conduct online session by two facilitators, where student discussion on case studies …