Digital Commons Network^™

Doctor To Be: A Memoir, Genesis Morlabaez

Library Creative Writing Contest

Genesis Morlabaez’s debut essay, Doctor to Be: A Memoir, reminisces about the author’s roots, her adolescence, and life events that have shaped her a person and student. Morlabaez’s narrative traces back to her earliest days, discussing how her father’s deployment fueled her ambition and shaped her career goals, further detailing the perseverance needed to achieve her aims in life while utilizing grit and determination to one day become a doctor.

Development Of An Online Warfarin Dosing Platform Using R Programming Language To Facilitate Healthcare Professional Duties And Limit Medication Related Errors., Monther Alsultan

Graduate Research Posters

Development of an online warfarin dosing platform using R programming language to facilitate healthcare professional duties and limit medication related errors.

Monther Alsultan, Joshua M. Morriss, Daniel Contaifer Jr, Suad Alshammari; Silas Contaifer, Rachel W Flurie, Dayanjan S. Wijesinghe

Department of Pharmacotherapy and Outcome Sciences

Objective: 1) Gain experience in developing platform agnostic, fully operational and clinically relevant web applications for effective pharmacist led patient care. 2) Create a decision- support tool using open source software to facilitate evidence-based management therapy of warfarin in clinical settings where it is available for everyone to use at anytime and anywhere.

Introduction: Healthcare …

The Effect Of The Interaction Of Exercise Training And Isolation On The Serotonergic System Of App/Ps1 Mice, Bailey J. Dansby

Graduate Theses/Dissertations

Alzheimer’s disease (AD) is a complex neurodegenerative disease that is characterized by the deposition of amyloid beta (Ab) peptides and, consecutively, by a loss of memory and cognitive functions. The amyloid cascade hypothesis suggests that Ab deposition is the main pathogenic of AD. There is evidence that both changes in production and clearance of Ab may be involved in AD pathology. Past studies have shown that exercise training leads to an upregulation in proteins directly involved with Ab clearance. Chronic stress is thought to exacerbate AD pathology by increasing production of Ab. Studies have also demonstrated a link between serotonin …

In Vitro Digestibility Of Forages Incubated With Equine Fecal Inoculum Stored Under Varying Conditions, Shianne K. Walther

Graduate Theses/Dissertations

This study evaluated the in vitro effect on digestibility of forages when incubated with microbial inoculum formed from equine feces stored under varying conditions. Fecal material was stored at four storage conditions of 12˚C for 6 hours, 12˚C for 12 hours, 23˚C for 6 hours and 23˚C for 12 hours under aerobic conditions. Stored fecal material was used to form microbial inoculum for use in an ANKOM Daisy II Incubator. Nine different forage samples were digested in the ANKOM Daisy II Incubator to evaluate interactions between storage condition of microbial inoculum and chemical composition of digested forage samples. Forage samples …

Lsu General Catalog 2021-2022, Louisiana State University And Agricultural And Mechanical College

LSU General Catalog

The LSU General Catalog describes all undergraduate and graduate departments and programs with degree requirements and courses offered for each one. The LSU General Catalog includes information on registration and financial aid as well as academic services offered to all students.

Climate Change And Innovation In Brazil: Threats And Opportunities, Gabriel Wedy, Cacia Pimentel

Sabin Center for Climate Change Law

In recent decades, Brazil has adopted a political approach focused on maintaining economic stability and consolidating inclusive social policies. However, despite repeated attempts, little progress has been made in overcoming difficulties within the country and making Brazil more competitive in the global market. Nevertheless, there seems to be an awakening and a certain consensus among scholars of Brazilian problems that the expected inclusive economic growth cycle may be achieved if Brazil invests in enhancing the bioeconomy business environment through bioenergy and innovation.

The actual crisis is fast–tracking two major transformations at the global level: the energy transition and the information …

Virginia Commonwealth University Undergraduate Bulletin [2021], Virginia Commonwealth University

VCU Bulletins

Undergraduate bulletin for Virginia Commonwealth University for the academic year 2021-2022. It includes information on academic regulations, degree requirements, course offerings, faculty, academic calendar, and tuition and expenses for undergraduate programs.

Immortality Through Mind Uploading And Resurrection, Adam M. Leis

Masters Theses

Technology in the last century has flourished exponentially. Previous fantasies are becoming cutting-edge discoveries like global communications, encyclopedic knowledge at the average person’s fingertips, and even medical advances used to improve and extend one’s quality of life and life expectancy. As technology pushes the boundaries of what is possible, ambitious visionaries look to solve the arguably greatest problem known to humanity: death. Transhumanists aiming to use technology to overcome this great human limitation, mortality, present the newest proposed solutions to life’s oldest challenge. One of these solutions, mind uploading, is perhaps the most ambitious, but it is not without its …

The Rees-Jones Center Research Brief: Developmental Status Of Young Children In Foster Care, Jill Mcleigh, Cecy Lazcano, Katie Tunnell

Research Briefs

Overview of 2021 study focused on the developmental status of young children in foster care.

childrens.com/fostercare

The Ethical Controversy Around Gene-Editing Technology, Katrina Powers

A with Honors Projects

In this honors project, the author discusses the risks and benefits of using CRISPR to edit genetics.

Closing The Gap: Raising Medical Professionals' Transgender Awareness And Medical Proficiency Through Pharmacist-Led Education, Ardsley P. Congdon Iii, Tiene, Cristofer Price, Robert L. Dufresne

Pharmacy Practice and Clinical Research Faculty Publications

Introduction: Patients who are transgender have unique population-specific needs and risk factors. Nationwide surveys of health profession school administrators indicate a gap in coverage of lesbian, gay, bisexual, and transgender health content in their curricula. To address this gap, a pharmacist-developed transgender–health care focused seminar was presented to medical professionals, trainees, and students accompanied by a novel education assessment scale.

Methods: The seminar was presented by a psychiatric pharmacy resident to health care professionals and trainees in various settings. Subjects covered during the seminar included terminology, diagnostic criteria and prevalence of gender dysphoria, nonhormonal treatment, gender-affirming hormone therapy, and other …

Jefferson Digital Commons Quarterly Report: October-December 2020, Kelsey Duinkerken, Msi, Larissa Gordon, Mslis, Med, Ma

Jefferson Digital Commons Reports

This quarterly report includes:

• Articles
• Departmental Reports
• Dissertations
• Doctorate of Occupational Therapy (OTD) Capstones
• Educational Materials
• Grand Rounds and Lectures
• JCPH Capstone Presentations
• Journals and Newsletters
• Library Presentations
• Posters
• The Big in Big Data Symposium
• What People are Saying About the Jefferson Digital Commons

The Public's Perception Of Medical Ultrasound, Bailey Klein, Michelle Anderson

Student Research Poster Presentations 2021

Ultrasound (sonography) is a primary imaging modality predominantly used in the Diagnostic Radiology department to aid in the findings of internal pathological conditions. Sonography has been used for medical diagnosis since the early 1970’s; however, in comparison to other imaging modalities, it is relatively young and evolving. Since Ian Donald’s discovery in obstetrical ultrasound, there has been a significant growth in Maternal and Fetal Medicine as well as an explosion in the use of non-medical obstetrical imaging, better known as keepsake or entertainment ultrasound. Unlike all other imaging examinations, in obstetrics, family members accompany the patient for viewing where the …

Effects Of Invasional Meltdown On Community Structure In Marine Ecosystems In The Damariscotta Estuary Of Maine, Kate Lazzeri

Student Research Poster Presentations 2021

Basibiont organisms form the foundation of marine ecosystems by providing additional space for new species to settle on as epibionts. Invasive epibionts may take advantage of this new basibiont presence, which leads to many harmful effects on native organisms such as competition for both resources and food. In some cases, invasive species facilitate recruitment of other invasive organisms, a phenomenon referred to as invasional meltdown, but it is not known if invasion of new basibionts increases invasive epibiont occurrence. The purpose of this study is to answer the following research questions: 1) does the invasion status of the basibiont alter …

Investigating Preservice Teachers’ Science Teaching Self-Efficacy: An Analysis Of Reflective Practices, Deepika Menon, Saiqa Azam

Department of Teaching, Learning, and Teacher Education: Faculty Publications

The purpose of this mixed methods research was to investigate the development of 55 preservice elementary teachers’ science teaching self-efficacy beliefs through analysis of their reflective practices in a science method course. This year-long study was conducted at two public universities located in the USA and Canada. Within the theoretical frameworks of science teaching self-efficacy and reflective practice, we examined how and in what ways preservice teachers’ reflections on their past science experiences and current science teaching practices contributed to their self-efficacy beliefs. Data were collected from pre- and post-course administrations of the Science Teaching Efficacy Belief Instrument-B (STEBI-B), written …

A Quadratic Traversal Algorithm Of Shortest Weeding Path Planning For Agricultural Mobile Robots In Cornfield, Le Zhang, Rui Li, Zhiqiang Li, Yuyao Meng, Jinxin Liang, Leiyang Fu, Xiu Jin, Shaowen Li

Department of Computer Science Faculty Scholarship and Creative Works

In order to improve the weeding efficiency and protect farm crops, accurate and fast weeds removal guidance to agricultural mobile robots is an utmost important topic. Based on this motivation, we propose a time-efficient quadratic traversal algorithm for the removal guidance of weeds around the recognized corn in the field. To recognize the weeds and corns, a Faster R-CNN neural network is implemented in real-time recognition. Then, an ultra-green characterization (EXG) hyperparameter is used for grayscale image processing. An improved OTSU (IOTSU) algorithm is proposed to accurately generate and optimize the binary image. Compared to the traditional OTSU algorithm, the …

Mechanics Of Low Dimensional Biomimetic Scale Metamaterials, Hossein Ebrahimi

Electronic Theses and Dissertations, 2020-2023

Combination of topology and material could play an important role in giving rise to nontraditional behavior in mechanical structures and is a typical strategy in nature. Topology is concerned with the geometrical and spatial properties of the objects, which are preserved under continues mechanical deformation of the object such as stretching, bending, twisting, etc. In this work, we focus on structures based on fish scale inspired surface topology. The utilized idea for surface topology is a bioinspired design on the substrate of biological scale-covered systems. Scales are a path breaking evolutionary adaptation that accompanied vertebrate evolution for the past 500 …

Fine-Grained Lower Bounds For Problems On Strings And Graphs, Gary Thomas Hoppenworth

Honors Undergraduate Theses

The motivation of this thesis is to present new lower bounds for important computational problems on strings and graphs, conditioned on plausible conjectures in theoretical computer science. These lower bounds, called conditional lower bounds, are a topic of immense interest in the field of fine-grained complexity, which aims to develop a better understanding of the hardness of problems that can be solved in polynomial time. In this thesis, we give new conditional lower bounds for four interesting computational problems: the median and center string edit distance problems, the pattern matching on labeled graphs problem, and the subtree isomorphism problem. These …

The Genomic Processes Of Biological Invasions: From Invasive Species To Cancer Metastases And Back Again, Fargam Neinavaie, Arig Ibrahim-Hashim, Andrew M. Kramer, Joel S. Brown, Christina L. Richards

Integrative Biology Faculty and Staff Publications

The concept of invasion is useful across a broad range of contexts, spanning from the fine scale landscape of cancer tumors up to the broader landscape of ecosystems. Invasion biology provides extraordinary opportunities for studying the mechanistic basis of contemporary evolution at the molecular level. Although the field of invasion genetics was established in ecology and evolution more than 50 years ago, there is still a limited understanding of how genomic level processes translate into invasive phenotypes across different taxa in response to complex environmental conditions. This is largely because the study of most invasive species is limited by information …

Deep Learning For Supervised Classification Of Temporal Data In Ecology, César Capinha, Ana Ceia-Hasse, Andrew M. Kramer, Christiaan Meijer

Integrative Biology Faculty and Staff Publications

Temporal data is ubiquitous in ecology and ecologists often face the challenge of accurately differentiating these data into predefined classes, such as biological entities or ecological states. The usual approach consists of transforming the time series into user-defined features and then using these features as predictors in conventional statistical or machine learning models. Here we suggest the use of deep learning models as an alternative to this approach. Recent deep learning techniques can perform the classification directly from the time series, eliminating subjective and resource-consuming data transformation steps, and potentially improving classification results. We describe some of the deep learning …

Global Economic Costs Of Aquatic Invasive Alien Species, Ross N. Cuthbert, Zarah Pattison, Nigel G. Taylor, Laura Verbrugge, Christophe Diagne, Danish A. Ahmed, Boris Leroy, Elena Angulo, Elizabeta Briski, César Capinha, Jane A. Catford, Tatenda Dalu, Franz Essl, Rodolphe E. Gozlan, Phillip J. Haubrock, Melina Kourantidou, Andrew M. Kramer, David Renault, Ryan J. Wasserman, Franck Courchamp

Integrative Biology Faculty and Staff Publications

Much research effort has been invested in understanding ecological impacts of invasive alien species (IAS) across ecosystems and taxonomic groups, but empirical studies about economic effects lack synthesis. Using a comprehensive global database, we determine patterns and trends in economic costs of aquatic IAS by examining: (i) the distribution of these costs across taxa, geographic regions and cost types; (ii) the temporal dynamics of global costs; and (iii) knowledge gaps, especially compared to terrestrial IAS. Based on the costs recorded from the existing literature, the global cost of aquatic IAS conservatively summed to US$345 …

Deep Learning For Supervised Classification Of Temporal Data In Ecology, César Capinha, Ana Ceia-Hasse, Andrew M. Kramer, Christiaan Meijer

Integrative Biology Faculty and Staff Publications

Temporal data is ubiquitous in ecology and ecologists often face the challenge of accurately differentiating these data into predefined classes, such as biological entities or ecological states. The usual approach consists of transforming the time series into user-defined features and then using these features as predictors in conventional statistical or machine learning models. Here we suggest the use of deep learning models as an alternative to this approach. Recent deep learning techniques can perform the classification directly from the time series, eliminating subjective and resource-consuming data transformation steps, and potentially improving classification results. We describe some of the deep learning …

Visualizing Barrier Dysfunction Using Clarity, Rachel Robbe

Lewis Honors College Thesis Collection

Epilepsy and Alzheimer’s disease are two prevalent neurological disorders. The blood-brain barrier (BBB) is a factor in why there are no long-term treatments for these diseases. The transporters in the neurovascular unit (NVU), which makes up the BBB, are highly specialized, so most drugs cannot pass the barrier to treat these diseases. It is unknown why drug uptake in the BBB varies in a diseased and wild-type brain, but one theory is that there are spatial differences in the NVU. One method for examining the NVU is the CLARITY tissue clearing technique which is unique in its capability to clear …

Effects Of Sleep Fragmentation On The Progression Of Alzheimer’S Disease, Lindsay Beechem

Lewis Honors College Capstone Collection

Alzheimer’s Disease (AD) is a neurodegenerative disease that is characterized by amyloid-beta (Aβ) plaques, neurofibrillary tangles, neuronal death, and profound cognitive impairment. Previous studies have indicated that increased Aβ and alterations in the daily sleep-wake cycle are early risk factors and possible predictors of AD. Acute sleep deprivation decreases Aβ clearance, and increased Aβ levels stimulate neuroinflammation and accelerate loss of neurons and synapses. Likewise, it has been shown that there are higher rates of sleep disorders in AD patients. However, limited studies have investigated whether sleep fragmentation accelerates the progression of AD pathology. This partial review will discuss experiments …

An Exploration Of Sleep Fragmentation And Sleep Enhancement In Mice, Frannie Salisbury

Lewis Honors College Capstone Collection

Alzheimer’s Disease (AD) is a neurodegenerative disease that is can be defined by amyloid beta (Aβ) plaques, neurofibrillary tangles, and neuronal death. AD patients have characteristically fragmented sleep, with frequent nighttime awakenings and daytime naps. Decreased clearance of Aβ from disrupted sleep may be a contributing factor in the progression of AD. This study investigated how sleep fragmentation effected the progression of AD in 3xTgAD mice. Results showed that sleep fragmented mice had significantly more Aβ build-up in the hippocampus and thus greater progression of AD when compared to control mice. Improving sleep may be one way to reduce the …

The Relationship Between Post-Stroke Depression And Post-Stroke Dysphagia, Janet Horn

MUSC Theses and Dissertations

Background: Post-stroke dysphagia and post-stroke depression (PSD) can have devastating effects on stroke survivors and substantial financial impacts on the healthcare system; however, there is a dearth of research examining this patient population. Thus, we studied the incidence, risk, and cost of PSD in patients with post-stroke dysphagia. Methods: We conducted a retrospective, cross-sectional study of individuals with a primary diagnosis of acute ischemic stroke and secondary diagnoses of dysphagia and/or depression using administrative claims data from the 2017 Medicare 5% Limited Data Set. Additionally, we developed a novel dysphagia severity index for use with administrative data and applied it …

Elucidating The Contribution Of The Baf A12t Mutation To Cellular Mechanisms Of Premature Aging, Maya Fadia Marwan El-Sabban

MUSC Theses and Dissertations

The nuclear envelope is a dynamic structure and organizing hub for cell structure and function. The underlying nuclear lamina is composed of a thick network of intermediate filaments, Lamin A/C and B, and inner nuclear membrane-associated proteins such as Lap2, Emerin and Man1. BAF, a central organizing protein, is a small, dimeric, essential protein that binds to dsDNA, proteins of the inner nuclear membrane and Lamin A. Cells with perturbations of the nuclear lamina display dysmorphic nuclei which have the potential to lead to altered gene expression, increased DNA damage events, and premature cellular senescence. In this study, we address …

Patient-Level Perspectives On The Use Of Novel Psychotherapeutics For The Treatment Of Substance Use Disorders By, Jory Donald Crull

MUSC Theses and Dissertations

Substance use disorders (SUDs) present a rapidly evolving public health crisis and many individuals with SUDs fail to maintain abstinence despite adherence to current standard of care treatment options. Prior research has demonstrated compounds with unique psychoactive properties may improve ability to maintain abstinence across a variety of SUDs; examples of such compounds include psilocybin, ketamine, and 3,4-Methylenedioxymethamphetamine (MDMA). However, target population support for mental health treatment using these medications is unknown. In this study, a cross-sectional survey (n=919) was administered to analyze patient-level perspectives on the use of these novel psychotherapeutics for the treatment of SUDs. We hypothesized that …

Peak Trailing Limb Angle And Propulsion Symmetry In Individuals With Below Knee Amputation, Aaron E. Embry

MUSC Theses and Dissertations

Background: Individuals with lower extremity amputation often present with kinematic and kinetic gait asymmetries and often have difficulty achieving symmetrical walking using their prescribed prosthesis. To understand the impact of limb loss on gait measures, studies often compare individuals with lower limb amputation to healthy control participants or compare the amputated limb to the uninvolved limb while completing a specified task like steady state walking. Commonly implemented treatments for individuals with lower limb amputation are based upon the assumption that equal use of both legs (symmetry) while completing bipedal tasks (e.g., walking) would be beneficial, matching the behavior seen in …

The Evaluation Of The Effectiveness Of Two Pipeline Programs For Matriculation And Retention Of Minority Students In A Medical School Program, Natalie G. Johnson

MUSC Theses and Dissertations

There is a constant need for diversity in the physician workforce, which means that there is also a critical need to diversify the medical school population. The Liaison Committee on Medical Education, the accrediting body of all U.S. medical schools monitors the compliance of medical education programs with recognized accepted standards including includes diversifying the physician workforce through pipeline programs and partnerships. The objective of this project is to evaluate outcomes of the Medical University College of Medicine’s Summer Institute (SI) program and the Postbaccalaureate Reapplication Program (PREP) in matriculating and retaining underrepresented minorities (URM) in medicine students. Out of …