Digital Commons Network^™

Park Reclamation: Tackling Invasive Species At The Oconee River Greenway In Milledgeville, Ga, Christine Mutiti

Academic Affairs

This project focused on the ecological restoration of a kudzu-invaded section of the Oconee River Greenway while integrating high-impact learning into the Environmental Methods and Measurements (ENSC 2000) course at GCSU. Kudzu (Pueraria montana), a Category I invasive species, has significantly disrupted native plant communities at the site, making it an ideal setting for applied learning and ecological intervention. The project engaged students in authentic environmental research by involving them in every stage of the process including problem assessment, methodology design, field implementation, data collection, and reflection.

Students initiated the first phase of invasive plant removal using mechanical …

Structural And Biological Properties Of Chitosan/Copper Polymetallic Complexes Synthesized From Apis Mellifera-Derved Chitosan, Dilnoza Sohibovna Isomitdinova, Gulnora Akmalovna Ikhtiyarova, Nazira Madusmanovna Kuchkarbayeva, Nafisa Akhrorovna Ergasheva

Technical science and innovation

In this study, a chitosan/copper (Ch/Cu²⁺) polymetallic complex was synthesized from chitosan obtained by the cryogenic method from Apis mellifera bees. The structural and physicochemical properties of the complex were investigated using FTIR, UV-Vis, XRD, TGA, and DLS analyses. FTIR spectra showed shifts in absorption bands at 1400-1339 cm⁻¹ and 1640-1550 cm⁻¹, confirming the coordination of Cu²⁺ ions with amino and hydroxyl groups. UV-Vis spectra revealed absorption peaks in the 410-540 nm range, while XRD analysis indicated new crystalline peaks at 2θ = 24°, 27°, and 37°. Thermal analysis demonstrated high thermal stability of the complex, and DLS confirmed a …

Improvement Of Ultrasonic-Convective Equipment And Beetroot (Beta Vulgaris L.) Drying Process, Jasur Esirgapovich Safarov, Shakhnoza Abduvaxitovna Sultanova, R. M. Najafli

Technical science and innovation

In the world, the air-dried food market is seeing rapid expansion, valued at USD 103.26 billion in 2021, out of which the Asia Pacific region consumed the maximum amount. The freeze-dried vegetable and fruit market is predicted to reach USD 132.7 billion by 2027. Processed vegetables are also exported to a large extent from India. Uzbekistan recorded excellent development in agriculture in 2024, with record harvests, better yields, and use of advanced machinery. Azerbaijan also demonstrated good agriculture growth and export performance. Beetroot has now been identified as a functional food containing bioactive compounds like betaines and dietary fiber that …

Twenty Minutes Of Corsi Block Tapping Task Training Does Not Improve Mental Rotation In Adults With Stroke, Sarah A. Kettlety, Giuliet L. Kibler, Andrew Hooyman, Christina K. Holl, Sydney Y. Schaefer, Kristan A. Leech

Physical Therapy Faculty Articles and Research

Background: Visuospatial function is commonly impaired post-stroke and is associated with motor learning and recovery. A single, twenty-minute Corsi Block Tapping Task (CBTT) training session improved visuospatial function in young neurotypical adults; however, it is unclear whether this training would improve visuospatial function in adults with stroke.

Objective: To understand if a single, twenty-minute CBTT training session improved visuospatial function in adults with stroke compared to a no-training control group of adults with stroke.

Methods: Participants post-stroke were assigned to one of two groups. The training group completed twenty minutes of computerized CBTT training. The control group completed a survey …

“I Just Need Another Set Of Eyes”: Understanding Students’ Idea Of The Writing Center, Isabelle M. Lundin, Neal Lerner

The Writing Center Journal

In this article, we describe writing center clients’ “idea” of the writing center based on interviews with 26 writing center users and qualitative coding of interview transcripts. Participants’ constructs of the writing center provide a lens to better understand how they perceive writing as an activity, the “writing culture” of the institution, the role of the writing center in their writing processes, and, ultimately, if they see writing centers in the way we would expect them to. The tensions we derived from our data are (1) between who and what tutors are and offer: discipline-specific expertise (including the disciplines of …

Exploring The World Of Medical Exoskeleton Robots: A Classification Guide, Javlonbek Rakhmatillaev, Vytautas Bučinskas

Technical science and innovation

This article describes the classification of exoskeletons. This classification is based on the use of exoskeletons in the medical field, shape, power source, generation, parts related to the human body, structural material, and control forms based on sensor and actuator devices. In addition, examples of each category are given. The main goal is to comprehensively evaluate medical exoskeletons, pay special attention to their functions and goals, conduct scientific research, and further develop these devices. As a result, a completely new type of classification of medical exoskeletons was developed. The developed new type of classification serves as an important guide in …

First Use Of The Ku-F600 Automated Analyzer For Descriptive Epidemiology Of Blastocystis Sp. In Erbil, Iraq., Hana Hakim Qadir, Hemdad Hawez Mawlood

Polytechnic Journal

Blastocystis is a common protozoan parasite of the gastrointestinal tract. This study aimed to determine the prevalence, risk factors, and potential pathogenicity of Blastocystis sp. in Erbil province, Iraq, using the KU-F600 Automated Feces Analyzer (AFA).Notably, this is the first study to use this device in Iraq. A total of 580 fecal specimens were collected from patients attendending Mehrabani Surgical Hospital. Samples were tested using the KU-F600 AFA, which incorporates AI-based examination of microscopically identified parasites. demographic and clinical data were collected through questionnaires. All the statistical calculations were performed by GraphPad Prism 10. The prevalence of Blastocystis sp. was …

Tng260 Is A Small-Molecule Corest Inhibitor That Sensitizes Stk11-Mutant Tumors To Anti-Pd-1 Immunotherapy, Leanne G Ahronian, Soumyadip Sahu, Minjie Zhang, Ayushi S Patel, Ke Geng, Gerald S Falchook, Alexander I Spira, Salman R Punekar, David R Spigel, Judy S Wang, Ferdinandos Skoulidis, Janaye Stephens, Mary Meynardie, Jaylen M Powell, Alfonso Lopez, Michela Ranieri, Magdalena A Ploszaj, Yi Jer Tan, Yeuan Ting Lee, Yi Yu, Jiehui Deng, Ting Chen, Patrick Mccarren, Alice Tsai, Suleman S Hussain, Brian Doyon, Kenjie Amemiya, Jacques Ermolieff, Preksha Shahagadkar, Nikitha M Das, Lauren R Flynn, Julie A Shields, Laney Danielczyk, Brian J Mcmillan, Andre Mignault, Samuel R Meier, Hsin-Jung Wu, David J Guerin, Douglas A Whittington, Chengyin Min, Iga Sienczylo, John P Maxwell, Heather J Dibenedetto, Hideo Watanabe, Brian B Haines, Alan Huang, Adam Crystal, Jannik N Andersen, Xinyuan Wu, Kwok-Kin Wong

Faculty, Staff and Student Publications

Patients with non–small cell lung cancer (NSCLC) with loss of the tumor suppressor gene STK11 are resistant to immune checkpoint therapies like anti–PD-1. In this study, we conducted an in vivo CRISPR screen that identified histone deacetylase 1 as a target to reverse anti–PD-1 resistance driven by loss of STK11 and developed TNG260, a potent small-molecule inhibitor of the CoREST complex with selectivity exceeding previously generated inhibitors in this class in preclinical studies. Treatment with TNG260 led to increased expression of immunomodulatory genes in STK11-deficient cancer cells. When combined with anti–PD-1, TNG260 induced immune-mediated stasis and/or regression in STK11 …

Preoperative Brain Mapping Predicts Language Outcomes After Eloquent Tumor Resection, Matthew T Muir, Kyle Noll, Sarah Prinsloo, Hayley Michener, Jeffrey I Traylor, Chibawanye I Ene, Ho-Ling Liu, Jeffrey S Weinberg, Frederick Lang, Brian A Taylor, Stephanie J Forkel, Sujit S Prabhu

Faculty, Staff and Student Publications

When operating on gliomas near critical language regions, surgeons risk either leaving residual tumor or inducing permanent postoperative language deficits (PLDs). Despite the advent of intraoperative mapping techniques, subjective judgments frequently determine important surgical decisions. We aim to inform data-driven surgery by constructing a non-invasive mapping approach that quantitatively predicts the impact of individual surgical decisions on long-term language function. This study included 79 consecutive patients undergoing resection of language-eloquent gliomas. Patients underwent preoperative navigated transcranial magnetic stimulation (TMS) language mapping to identify language-positive sites ("TMS points") and their associated white matter tracts ("TMS tracts") as well as formal language …

Treating Low-Concentration Methane Emissions Via A Methanotroph-Based Biotrickling Filter: Techno-Economic And Life Cycle Assessment, Waaseyaaban Landgren, Robert Handler, David Shonnard, Mary E. Lidstrom

Michigan Tech Publications

Methane, a greenhouse gas which has a global warming potential 80 times greater than carbon dioxide on a 20-year time scale, greatly contributes to global warming. Removing 1 Gt of atmospheric methane by 2050 would limit global temperature increase from reaching 1.5 °C. Currently, biotrickling filter systems for removing atmospheric methane via methanotrophs exist, but not for very low methane concentrations (< 1 v%). Recent work at the University of Washington to isolate and improve a microbial strain which thrives at 500 ppmv CH4 has removed one obstacle in making this technology feasible. In this study, techno-economic and environmental life cycle assessment analyses conducted on this process have assessed its economic feasibility, greenhouse gas reduction potential, and possible areas of improvement. Study results show that at 500 ppmv CH4, this process could remove atmospheric methane at a cost of USD 3992–5224/tCH4. The best-performing case also produces annual net reductions in warming potential by 276–311 tCO2e/120 m3 process unit deployed. Many opportunities exist to improve the outcomes of the baseline analysis even further, especially related to reducing the transport distance of media and harvested biomass.

Understanding Callus Types In Maize By Genetic Mapping And Transcriptional Profiling, Guifang Lin, Yan Liu, Tej Man Tamang, Yang Qin, Mingxia Zhao, Hairong Wei, Et. Al.

Michigan Tech Publications

Plant transformation efficiency is highly dependent on species, individual genotypes, and tissue types. In maize, immature embryos are regularly used for transformation. The process relies heavily on callus development, as it is intricately associated with somatic embryogenesis and subsequent plant regeneration, both of which directly affect transformation efficiency. Immature embryos of the segregation progeny derived from the two inbred parents, a transformation-amenable line A188 and a recalcitrant line B73, can be cultured to form two primary callus types: Type I and Type II. The Type II callus grows faster and is a favorable type for regeneration. Here, Type I and …

Resilience And Vulnerabilities Of Tumor Cells Under Purine Shortage Stress, David Moon, Michael A Sun, Hong Zhang, Xue Jiang, Fan Zhang, Nomi Tserentsoodol, Michelle L Bowie, Christopher J Pirozzi, Daniel J George, Robert Wild, Xia Gao, David M Ashley, Yiping He, Jiaoti Huang

Faculty, Staff and Students Publications

Purpose: Purine metabolism is a promising therapeutic target in cancer; however, how cancer cells respond to purine shortage, particularly their adaptation and vulnerabilities, remains unclear.

Experimental design: Using the recently developed purine shortage-inducing prodrug DRP-104 and genetic approaches, we investigated the responses in prostate, lung, and glioma cancer models.

Results: We demonstrate that when de novo purine biosynthesis is compromised, cancer cells employ microtubules to assemble purinosomes, multiprotein complexes of de novo purine biosynthesis enzymes that enhance purine biosynthesis efficiency. Although this process enables tumor cells to adapt to purine shortage stress, it also renders them more susceptible to the …

Alterations Of The Upper Respiratory Microbiome Among Children Living With Hiv Infection In Botswana, Sifelane Boiditswe, Leabaneng Tawe, Shimane Lekalake, Mogomotsi Matshaba, Andrew P Steenhoff, Tonya Arscott-Mills, Kristen A Feemster, Samir S Shah, Nathan Thielman, Coleen K Cunningham, Lawrence A David, David M Murdoch, Matthew S Kelly

Faculty, Staff and Students Publications

Children living with HIV (CLWH) are at high risk of colonization and infection by respiratory pathogens, though this risk can be reduced by other microbes in the upper respiratory microbiome. The impact of HIV infection on the pediatric upper respiratory microbiome is poorly understood, and we sought to address this knowledge gap by identifying associations between HIV infection and the nasopharyngeal microbiomes of Batswana children. We enrolled Batswana CLWH (< 5 years) and age- and sex-matched HIV-exposed, uninfected and HIV-unexposed, uninfected children in a cross-sectional study. We used shotgun metagenomic sequencing to compare nasopharyngeal microbiomes by HIV status. Among the 143 children in this study, HIV and HIV-associated immunosuppression were associated with alterations in nasopharyngeal microbiome composition, including lower abundances of Corynebacterium species associated with resistance to bacterial pathogen colonization. These findings suggest that the upper respiratory microbiome may contribute to the high risk of respiratory infections among CLWH.

Estrogen-Related Receptor Alpha Promotes Skeletal Muscle Regeneration And Mitigates Muscular Dystrophy, Thi Thu Hao Nguyen, Ya Xiang Huang, Svitlana Poliakova, Citu Citu, Eira Mann, Danesh H Sopariwala, Zhongming Zhao, Ashok Kumar, Vihang A Narkar

The Brown Foundation: Institute of Molecular Medicine

Skeletal muscle regeneration in chronic muscle diseases such as Duchenne Muscular Dystrophy (DMD) has remained clinically unsurmountable. Estrogen‐related receptor alpha (ERRα) plays a critical role in adult skeletal muscle metabolism and exercise fitness. Whether ERRα activation can drive muscle regeneration and mitigate dystrophy in DMD is not known. We have investigated ERRα signaling in pre‐clinical models of acute muscle injury and DMD. ERRα is induced in differentiating C2C12 myoblast and regenerating muscle. ERRα silencing suppressed proliferation and differentiation in C2C12 myoblasts. RNA sequencing revealed that angiogenic factor and proliferation genes were downregulated by ERRα knockdown in proliferating cells, whereas oxidative …

Dendritic Atoh1a+ Cells Serve As Merkel Cell Precursors During Skin Development And Regeneration, Evan W Craig, Erik C Black, Samantha Z Fernandes, Ahlan S Ferdous, Camille E A Goo, Sheridan M Sargent, Elgene J A Quitevis, Avery Angell Swearer, Nathaniel G Yee, Jimann Shin, Lilianna Solnica-Krezel, Jeffrey P Rasmussen

2020-Current year OA Pubs

Sensory cells often adopt specific morphologies that aid in the detection of external stimuli. Merkel cells encode gentle touch stimuli in vertebrate skin and adopt a reproducible shape characterized by spiky actin-rich microvilli that emanate from the cell surface. The mechanisms by which Merkel cells acquire this stereotyped morphology from keratinocyte progenitors are unknown. Here, we establish that dendritic Merkel cells (dMCs) express atonal homolog 1a (atoh1a), extend dynamic filopodial processes, and arise in transient waves during zebrafish skin development and regeneration. We find that dMCs share molecular similarities with both basal keratinocytes and Merkel cells, yet display mesenchymal-like behaviors, …

Vaccine Effectiveness Against Influenza A(H1n1), A(H3n2), And B-Associated Hospitalizations, United States, 1 September 2023 To 31 May 2024, Nathaniel M Lewis, Jennie H Kwon, Et Al.

2020-Current year OA Pubs

BACKGROUND: The 2023-2024 influenza season included sustained elevated activity from December 2023 to February 2024 and continued activity through May 2024. Influenza A(H1N1), A(H3N2), and B viruses circulated during the season.

METHODS: During 1 September 2023 to 31 May 2024, a multistate sentinel surveillance network of 24 medical centers in 20 US states enrolled adults aged ≥18 years hospitalized with acute respiratory illness. Consistent with a test-negative design, cases tested positive for influenza viruses by molecular or antigen test, and controls tested negative for influenza viruses and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Vaccine effectiveness (VE) against influenza-associated hospitalization …

Sub-Ciliary Localization Of Cep290 And Effects Of Its Loss In Mouse Photoreceptors During Development, Alexandre P. Moulin, Alexandra Graff-Meyer, Carlo Rivolta, Theodore G. Wensel

Faculty, Staff and Students Publications

No abstract provided.

Melusine And Yde Et Olive: Subversive Narrative Power In The Medieval Female Body, Anna Prawer

Locus: The Seton Hall Journal of Undergraduate Research

This paper delves into the representation of the female body in Medieval Literature, focusing on the texts of 'Melusine' and 'Yde et Olive'. The paper explores how these two texts represent bodily difference and transformation as a source of subversive narrative power. Rather than functioning merely as symbols of weakness or instability compared to the stable and coherent male body, the female bodies in these texts disrupt social and gender norms, generating new possibilities for identity and narrative authority.

Behavioral Inhibition And Cognitive Control In An Emotional Go/No-Go Task, Amanda Burns

Locus: The Seton Hall Journal of Undergraduate Research

Behavioral inhibition is a temperamental tendency associated with heightened risk for developing anxiety disorders. Individuals with behaviorally inhibited temperament tend to avoid or withdraw from novel situations, which may be associated with prefrontal cortical activation related to cognitive control. The purpose of this study is to investigate how behavioral inhibition influences cognitive control using an emotional Go/No-go task. Participants completed the State-Trait Anxiety Inventory (STAI-Y) which assesses feelings of anxiousness, and the Adult Measure of Behavioral Inhibition, which measures behaviorally inhibited temperament. Participants then completed an emotional Go/No-go task utilizing neutral and negative stimuli and asking participants to quickly respond …

Conversations With Hsls:09: Reflections On College-Going By Black Queer And Trans Scholars, Dion T. Harry, Quortne R. Hutchings, Christopher Sewell, Lorae Bonamy-Lohve, Taylor R. Lewis

Journal of Queer and Trans Studies in Education

This paper threads together quantitative data on Black QT students from the HSLS:09 data set, while connecting the authors' lived experiences about the college-going process. According to this data, Black QT high school students were heavily influenced by parents and peers and less influenced by school counselors and teachers regarding decisions about college and post-high school trajectories. In response, we engage in collaborative autoethnography (CAE) to center our narratives as Black QT people by threading our commonalities and differences to highlight what tensions and connections emerged from our experiences with the college-going process to add context to the aforementioned data.

Microclimatic Conditions In Shulgan-Tash Cave (Southern Ural, Russia): Implications For The Preservation Of Eastern Europe’S Largest Paleolithic Art Collection, Olga Chervyatsova, Rayan Akhmedyanovb, Nailya Saifullina, Ludmila Kuzmina, Mihael Kotov, Yuri Dublyansky

International Journal of Speleology

This study presents the results of a long-term investigation of the microclimatic conditions in Shulgan-Tash Cave (Southern Urals, Russia), which hosts the largest assemblage of Upper Paleolithic paintings (ca. 16.3–19.6 ka) in Eastern Europe. The cave exhibits two distinct seasonal ventilation regimes – winter and summer – differentially influence its two levels of galleries. In the Lower Level, which contains 83% of the images, near-atmospheric CO₂ concentrations persist year-round, and temperature variations associated with seasonal infiltration events are minimal (1.0–1.3°C). By contrast, the Upper Level, including the decorated Hall of Paintings, is affected by downdrafts of CO₂-rich …

J Am Coll Dent 2024 91 1

Journal of the American College of Dentists

The Journal of the American College of Dentists (JACD) publishes scholarly articles, editorials, essays, and reflections addressing the ethical, professional, and social dimensions of dentistry. The Journal serves as a forum for advancing ethics, professionalism, leadership, and excellence within the dental community. By fostering dialogue across disciplines and perspectives, JACD provides readers with insights that encourage ethical, professional practice, lifelong learning, and service to the public, reinforcing dentistry’s commitment to advancing oral healthcare and the common good.

J Am Coll Dent 2023 90 1

Journal of the American College of Dentists

The Journal of the American College of Dentists (JACD) publishes scholarly articles, editorials, essays, and reflections addressing the ethical, professional, and social dimensions of dentistry. The Journal serves as a forum for advancing ethics, professionalism, leadership, and excellence within the dental community. By fostering dialogue across disciplines and perspectives, JACD provides readers with insights that encourage ethical, professional practice, lifelong learning, and service to the public, reinforcing dentistry’s commitment to advancing oral healthcare and the common good.

21st-Century Dental Public Health: Revisiting The Role Of Community Water Fluoridation, Larry Williams, Preetha Kanjirath

Journal of the American College of Dentists

Community water fluoridation (CWF) has been celebrated as a major public health achievement, significantly reducing dental caries and narrowing oral health disparities. While historically effective, today’s fluoride exposure landscape has shifted, with multiple sources contributing to cumulative intake. This article reviews the scientific foundation, mechanisms of action, public health benefits, and ethical considerations surrounding CWF, alongside real-world outcomes from policy reversals. It examines contemporary concerns, including potential neurodevelopmental risks and vulnerable populations, and calls for recalibrated policies that maintain caries prevention benefits while monitoring total fluoride exposure to ensure safety in modern contexts.

Ethical Dilemmas Surrounding Community Water Fluoridation, Roopwant Kaur, Herminio Perez, Mark Moss

Journal of the American College of Dentists

Since the 1950s, community water fluoridation (CWF) has stood as a cornerstone of dental public health. However, a growing amount of public scrutiny necessitates reflection on the ethical basis for coming to a firm position on the topic. Aside from CWF, fluoride in the form of ingestible supplements has recently been identified as a concern by the US Food and Drug Administration. Indeed, it is challenging to wade through the facts, opinions, misinformation, and policy shifts. This article examines the ethical dilemmas that surround CWF through the lens of the American Dental Association (ADA) Principles of Ethics and Code of …

J Am Coll Dent 2025 92 1

Journal of the American College of Dentists

The Journal of the American College of Dentists (JACD) publishes scholarly articles, editorials, essays, and reflections addressing the ethical, professional, and social dimensions of dentistry. The Journal serves as a forum for advancing ethics, professionalism, leadership, and excellence within the dental community. By fostering dialogue across disciplines and perspectives, JACD provides readers with insights that encourage ethical, professional practice, lifelong learning, and service to the public, reinforcing dentistry’s commitment to advancing oral healthcare and the common good.

J Am Coll Dent 2021 88 4

Journal of the American College of Dentists

The Journal of the American College of Dentists (JACD) publishes scholarly articles, editorials, essays, and reflections addressing the ethical, professional, and social dimensions of dentistry. The Journal serves as a forum for advancing ethics, professionalism, leadership, and excellence within the dental community. By fostering dialogue across disciplines and perspectives, JACD provides readers with insights that encourage ethical, professional practice, lifelong learning, and service to the public, reinforcing dentistry’s commitment to advancing oral healthcare and the common good.

J Am Coll Dent 2021 88 1

Journal of the American College of Dentists

The Journal of the American College of Dentists (JACD) publishes scholarly articles, editorials, essays, and reflections addressing the ethical, professional, and social dimensions of dentistry. The Journal serves as a forum for advancing ethics, professionalism, leadership, and excellence within the dental community. By fostering dialogue across disciplines and perspectives, JACD provides readers with insights that encourage ethical, professional practice, lifelong learning, and service to the public, reinforcing dentistry’s commitment to advancing oral healthcare and the common good.

J Am Coll Dent 2019 86 4

Journal of the American College of Dentists

The Journal of the American College of Dentists (JACD) publishes scholarly articles, editorials, essays, and reflections addressing the ethical, professional, and social dimensions of dentistry. The Journal serves as a forum for advancing ethics, professionalism, leadership, and excellence within the dental community. By fostering dialogue across disciplines and perspectives, JACD provides readers with insights that encourage ethical, professional practice, lifelong learning, and service to the public, reinforcing dentistry’s commitment to advancing oral healthcare and the common good.

J Am Coll Dent 2019 86 2

Journal of the American College of Dentists

The Journal of the American College of Dentists (JACD) publishes scholarly articles, editorials, essays, and reflections addressing the ethical, professional, and social dimensions of dentistry. The Journal serves as a forum for advancing ethics, professionalism, leadership, and excellence within the dental community. By fostering dialogue across disciplines and perspectives, JACD provides readers with insights that encourage ethical, professional practice, lifelong learning, and service to the public, reinforcing dentistry’s commitment to advancing oral healthcare and the common good.