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Next-Generation Protein Sequencing (Ngps) For Determining Complete Sequences For Unknown Proteins And Antibodies, Alexis S. Howard

Honors Undergraduate Theses

Next-Generation protein sequencing (NGPS) creates newfound ways of fully identifying every protein species in a single biological organism. It is an effort to use technology to determine proteomic data. The purpose of this research project is to use the current technology to sequence proteins and potentially find treatments for some diseases that are common today. Through NGPS, scientists can identify low abundant proteins including those that go through post-translational modifications (PTM) [1]. NGPS will allow us to fully determine protein sequences from protein samples using mass spectrometry with the ultimate goal of being able to determine the primary sequence of …

The Demographic, Behavioral, And Clinical Factors Associated With The Quality Of Life Of Cancer Survivors, Odette Chirinos

Honors Undergraduate Theses

The objective of this thesis is to assess the prevalence of low quality of life in adult cancer survivors and predictors for these low scores, separately for physical and mental quality of life. Possible predictors can include sociodemographic, clinical, and behavioral factors. The data source for this thesis is the National Health and Nutrition Examination Survey (NHANES) 2005-2012. The sample population included 1244 cancer survivors 20 years or older that answered “yes” to the question “have you ever been told by a doctor or other health professional that had cancer or malignancy of any kind?” Mental and physical health scores …

Exploring Interleukin 21 And Its Role In Humoral Immunity In The Mouse Model Of Influenza Infection, Samantha E. Gallahan

Honors Undergraduate Theses

In summary, this study will be focused on Il-21 and its implications in the antibody response in influenza. The isotype classes primarily involved in this process will also be examined. This will be accomplished by looking at the serum of mice and analyzing the present influenza specific antibodies using ELISA. Another goal was to optimize the ELISA in order to make it sensitive enough to catch small differences in the results. This topic is important due to its implications for improving influenza vaccinations and preventions as current vaccines are not 100% effective. Influenza contributes to significant disease and death around …

Misinformation In The Media And Its Influence On Racism, Jared Champa

Honors Undergraduate Theses

The purpose of the current study was to examine how the media's positive and negative portrayals related to racism impact the viewer's attitudes regarding African Americans. Previous research has shown how misinformation in the media can implicitly affect one's level of racism. Previous research has also shown that gender and one's sociodemographic status can affect the way individuals perceive misinformation. This study aimed to address the relationship between misinformation depicting racist views directed toward African Americans and consumer's attitudes toward African Americans. It was hypothesized that exposure to misinformation will have a significant impact on participants' level of racism. A …

Identifying Pathways Affected By The Hrpa Rna Helicase, Brandon Simons

Honors Undergraduate Theses

HrpA is a poorly characterized DEAH-box helicase found in many enterobacteria, including Escherichia coli. For unknown reasons, HrpA causes sickness in cells lacking Elongation Factor P, a transpeptidation enhancer that prevents ribosome stalling at proline-rich motifs during protein synthesis. HrpA's C-terminal RNA binding motifs and association with the degradosome suggest this protein interferes with an important translational process. Deletion of hrpA does not produce an overt phenotype, obscuring its role in cellular physiology. This thesis sought to identify pathways affected by this highly conserved protein. A bioinformatic analysis of HrpA's predicted interactome was conducted using a database called STRING. In …

"To Love Or To Loathe": The Impact Of Childhood Bullying On The Quality Of Adult Romantic Relationships, Richelle M. Cruz Quetell

Honors Undergraduate Theses

The current study explored whether childhood bullying has a lasting impact on the quality of adult romantic relationships. A complete case analysis of 86 participant responses examined the association between bullying, insecure attachment, romantic relationship satisfaction, and trust. The findings partially supported study hypotheses. Specifically, a significant positive correlation between social manipulation, a type of bullying, and avoidant attachment was found. Physical victimization was also positively correlated with trust. However, no significant association between bullying and relationship satisfaction was found. Exploratory multiple regression analysis showed that both physical victimization and romantic relationship satisfaction predict the level of trust experienced in …

Examining The Relationship Between Mental Health Conditions And Risk Perception In Determining Covid-19 Preventative Health Behaviors, Krupali Patel

Honors Undergraduate Theses

Depression and anxiety are relatively common among college students and research suggests that risk perceptions may be modulated by these mental health conditions. In addition, studies have demonstrated that higher perception of risk predicts more frequent practice of preventative health behaviors, and this relationship may also be modulated by depression and anxiety. The present study examined the relationship between these factors in the context of COVID-19. Using survey data from undergraduate students, risk perceptions about COVID-19, self-reported practice of COVID-19 preventative behaviors, and their relationship were compared between those with and without the common mental health conditions of Major Depressive …

Association Between Plasma Genistein And Health-Related Quality Of Life In Breast Cancer Survivors, Tran Pham

Honors Undergraduate Theses

According to the American Cancer Society, breast cancer is the most commonly diagnosed cancer and is the second leading cause of cancer death in American women. Breast cancer screenings and improvement in treatments have resulted in the rising number of survivors in the recent decade. This urged the need for post-diagnosis lifestyle changes to improve breast cancer patients' quality of life. Many studies found soy food, the primary dietary source of phytoestrogens, has a protective effect against breast cancer recurrence and mortality. Dietary phytoestrogens can be classified into two groups: isoflavones and lignans. Daidzein and genistein were identified as the …

The Effects Of Bioidentical Hormone Replacement Therapy On Irritability In Menopausal Women, Giavana Hanna

Honors Undergraduate Theses

The start of the menopausal transition involves the introduction of various somatic, urogenital, and psychological symptoms; of the symptoms, irritability is one of the main complaints reported by women. The use of bioidentical hormone replacement therapy has become more prevalent in society, specifically treating the somatic and urogenital symptoms of the menopausal transition. This study aims to determine the effects of bioidentical hormone replacement therapy (BHRT) on irritability in menopausal women. To test the hypotheses, an online survey was distributed to women via social media and word-of-mouth. Participants were asked to respond to various questions, which were then analyzed based …

The Effect Of Microdosing Classical Psychedelics On Cognitive Performance, Michael Harris

Honors Undergraduate Theses

Public interest and scientific inquiry are currently bringing psychedelic research back into the spotlight after a decades-long respite from clinical human trials. A majority of the research during this recent renaissance has surrounded applications of psychedelics in the fields of mental health. Less attention is being focused to other research areas where psychedelics may also prove informative, such as cognition and information processing. A common trend taking place is the act of administering very small doses of psychedelics as a potential cognitive enhancer, called microdosing. With less research being focused on these areas however, it is not well documented whether …

Craving For Attention: Examining Mood And Attention Bias In The Moment As Predictors Of Alcohol Craving, Katie R. Moskal

Honors Undergraduate Theses

Alcohol consumption is prevalent on college campuses. There are a number of theories that seek to explain the link between alcohol use and mood. The affective-processing model posits that negative affect may interact with subconscious cognitive factors, such as attention bias (AB), to promote drug-seeking behavior. In contrast, the incentive-sensitization model suggests positive mood may drive drug seeking behavior, and this drive may be moderated by cognitive factors (e.g., AB). The current study hypothesized that both positive and negative mood would be associated with drug craving in the moment. It was further hypothesized that AB would moderate mood-craving associations. Participants …

Exploring Factors Of Acceptance Of Chip Implants In The Human Body, Radha D. Chebolu

Honors Undergraduate Theses

The technology and telecommunication industries have made significant progress in the past few decades leading to several inventions and designs that have significantly improved efficiency in all aspects of human life. These innovations in science and technology improve our quality of life. Modern technology enables us to access vast amounts of information and services through a network of interconnected computers and machines. Recently, various technologies have been proposed to incorporate the human body into this incorporated network. One of these proposed technologies are chip implants meant to be inserted into the human body at various suitable body parts, such as …

Relationship Between Cannabis Use And Immediate, Delayed, And Working Memory Performance Among Older Adults, Madison H. Maynard

Honors Undergraduate Theses

Cannabis is increasingly accessible in the United States for recreational and/or medical use. Additionally, the Baby Boomer birth cohort exhibits a greater prevalence of cannabis use than prior generations of older adults. Past research has most frequently addressed the potential cognitive effects of cannabis use in populations of adolescents and young adults. Some of these studies suggest that cannabis use is chronically associated with worse performance on tasks of verbal working memory and executive functioning, however, due to methodological variation and a wide variety of potential confounds including duration of abstinence and frequency of use, results are still inconclusive. Through …

The Role Of Ms-818 In Altering Age-Related Characteristics Of An In Vitro Model Of Senescence In Neural Stem Cells, Sandeep Sreerama

Honors Undergraduate Theses

Aging of the brain is the leading risk factor for neurodegenerative diseases and brain cancers and has deleterious effects on brain functions. It follows that attempts to reverse the aging process may be therapeutically valuable. Neural stem cells (NSC) have been shown to play a critical role in maintaining brain functions, and their number is severely decreased with age. The development of senescence-like characteristics and declining functions in NSCs have been proposed to be responsible for brain aging and tumorigenesis. MS-818 is a pyrrolopyrimidine that has been shown to increase the NSC population and reverse the decline of behavioral function …

The Implications Of Case-Based Learning (Cbl) On Biochemistry Education: An Integrative Literature Review, Ryan C. Ripert

Honors Undergraduate Theses

The COVID-19 has significantly impacted the world as we know it, especially in higher education institutions. In response to COVID-19, most colleges and universities were forced to close their doors to students and switch to online learning over Zoom. Although most students are adjusted well to this new mode of education, other students, such as individuals pursuing degrees in the sciences, have difficulty adapting to the online mode of instruction. Case-based learning (CBL) is considered one of the best strategies in teaching a course like Biochemistry in a large classroom setting. Implementing CBL in biochemistry education may increase student engagement …

Influences Of Public Opinion Concerning Abortion, Enya A. Brackins

Honors Undergraduate Theses

This Honors Undergraduate Thesis seeks to examine the influences of public opinion on abortion policy. Race, Partisanship, and Gender are identified as driving forces which influences the public's opinion. As social and racial movements continue to progress so does the influence that it has on policy makers.

Awareness Of Genetic Predispositions That Increase The Risk Of Breast Cancer, Carly Huber

Honors Undergraduate Theses

Breast cancer is the most commonly diagnosed cancer in women in the United States and is the leading cause of cancer-related death among women worldwide. Certain demographics, such as racial/ethnic, age, and gender groups, are underrepresented in breast cancer studies. This lack of representation results in issues with creating genetic tests, as variants associated with those groups are not being detected. Furthermore, these underrepresented demographics are receiving a worse prognosis than those that are overrepresented in research. This study aimed to understand how informed the understudied racial/ethnic, gender, and age populations are regarding breast cancer and genetic testing compared to …

Fluid-Structure Interaction For A Deformable Anisotropic Cylinder: A Case Study, Jared T. Decker

Honors Undergraduate Theses

For a structure designed to interact with the surrounding fluid, structural deformation under loads induced by fluid flows is an important factor to consider, and one which is traditionally difficult to account for analytically. Coupling the finite element method for structural analysis with the finite volume method for the determination of fluid response allows for accurate simulation of the pressure and shearing loads applied by the fluid onto the fluid-structure interface, while also determining localized structural displacements that would cause changes to the geometry of the interface. This work seeks to simulate the behavior of cylinders with varying heights and …

Analysis Of Lubricants At Trace Levels Using Infrared Spectroscopy, Tanmai Bandarupalli

Honors Undergraduate Theses

Analysis of trace evidence involved in sexual assault investigations holds considerable potential as a newer avenue of identification when bulk, larger evidence is not found or unreliable. Trace analysis of forensic materials involves common findings such as strands of hair, residues left on clothing, shards of paint or glass, etc. In recent research focused on the analysis of trace materials found as evidence in a sexual assault, there has been promise in condom and bottled lubricant classification based on their chemical profiles that can provide an associative link in an investigation. Few studies have considered the examination of lubricant evidence …

Generation Succession: Reconceptualizing Generations And Their Mark On The Social Landscape, Ryan Hill

Honors Undergraduate Theses

This thesis explores the sociological underpinnings of generation by drawing on Mannheim's theory of generations and applying the concept as an explanative force in long-term societal change. Individuals of the same cohort and national culture make for a generation location; they share a similar parameter of experience within the stream of history. As individuals collectively enter into the formative years of adolescence, significant Imprint Events can forge a bond between them in terms of mindset and worldview (Habitus), which endure over the life course. This group of individuals, as a result, develop a generational consciousness that is distinct from other …

History, Ideology, And Evolution Of Criminal Profiling, Gayatri M. Ramesh

Honors Undergraduate Theses

Criminal profiling is the art of using evidence and crime scenes to deduce who the criminal is and where the criminals might be going next. In addition, criminal profiling is also used to link cases together with like victims. While its usage in law enforcement is relatively new, forms of the art have been around for decades. This thesis researches the history, ideology, and evolution of criminal profiling from the early 1870s to its current state. Cesare Lombroso and his research founded criminal profiling by examining how criminals and their minds vary from law-abiding citizens. Following Lombroso, various forms of …

A Qualitative Systemic Review On Maternal Health Disparities In Haitian Women, Alexandra Jean-Louis

Honors Undergraduate Theses

Background: It is universally known that pregnancy is a vulnerable time for a woman's health. Women of all backgrounds endure significant physiological and anatomical changes during pregnancy and after childbirth. But the latest research studies have called attention to the unique experience of Black mothers. Compared to other racial and ethnic groups, Black women encounter health disparities at an all-time higher rate. According to research studies conducted in Haiti and the United States, Haitian women are amongst the community of Black women who are experiencing disproportionate maternal outcomes.

Research Aims: The aim of this systematic review is to …

Targeting T Cell Metabolism To Ameliorate Graft-Versus-Host Disease, Karin Zikra

Honors Undergraduate Theses

Hematopoietic stem cell transplantation (HSCT) is an important form of therapy for hematological genetic disorders and malignancies, particularly hematological cancers. However, common usage of this procedure is obstructed by graft-versus-host disease (GvHD), in which transplanted donor T cells wage an attack on recipient antigens, causing severe tissue damage and mortality. GvHD prognosis remains poor, and current treatment methods continue to be insufficient, especially for patients with more advanced and severe GvHD. T cells have been identified as the fundamental force behind GvHD, and their cellular metabolism is deemed vital to their fate and function, especially in pathogenic environments. A hallmark …

Interactive Coast, Manuela Monsalve

Honors Undergraduate Theses

Interactive Coast is a moving-image art installation that will mix 16mm film and digital footage. Inspired by the cyclical nature of the biological concept of succession, this installation will focus on human interactions with nature and architecture, specifically at the beaches on the East Coast of Florida. In its biological definition of the word, “Succession is the gradual transformation or creation of a biological community as new species move into an area and modify local environmental conditions” (Rehkopf 1581). The coast, once with its undeveloped tract of mangroves and sand dunes is now interspersed with construction, oil spills, and …

Impact Of Mature, Female Eastern Red Cedar (Juniperus Virginiana L.) Trees On Soil Seed Bank In The Mixed-Grass Prairie Of The Northern Great Plains, Austin Domeier, Lan Xu, Alexander Smart

Native Plant Focused Publications

Eastern red cedar (ERC) (Juniperus virginiana L.) trees are invading prairies throughout the Great Plains due to fire suppression and overgrazing. This encroachment poses a threat to native plant communities in terms of their reproduction, regeneration, diversity, and invasiveness. It is unknown how ERC trees impact belowground propagules in the mixed-grass prairie and how it may alter heterogeneity. The objective of this study was to evaluate how mature female ERC trees impact the soil seed bank composition. In October 2020 in southcentral South Dakota ten female ERC trees with canopy diameters = 5-10 m, similar environmental characteristics, and isolated from …

Evaluation Of Wave Attenuation And Shoreline Protection Provided By Us Atlantic And Gulf Coast Oyster Reef Living Shoreline Projects During Storm Events, Matthew Virden, Eric Sparks

CREC Publications

No abstract provided.

Analyzing Pathways To The J.D. With National Student Clearinghouse Data, Tiffane Cochran, Lauren Walker

AccessLex Institute Research

The lack of diversity in legal education and the profession is a well-established fact. Data and rich commentary from law school scholars clearly illustrate barriers to entry for historically underrepresented groups. Yet, we continue to see persistent gaps in law school and bar admission among ethnic minorities—particularly, Black and Latinx students. And although information on first-generation and socioeconomically disadvantaged groups is harder to obtain, we also find inequitable access for these students where data are available.

Although discussions of law school diversity necessitate examination of students’ racial and socioeconomic backgrounds, they also require an analysis of the pathways students must …

Karl Tomm’S Internalized Other Interviewing: From Theory To Practice, Robin Akdeniz

Department of Family Therapy Dissertations and Applied Clinical Projects

Over the last 40 years, the Canadian psychiatrist and family therapist Karl Tomm has been a key contributor to postmodern developments in family therapy (Collins & Tomm, 2009; Strong et al., 2008; Tomm, Hoyt, & Madigan, 2001). This dissertation traces the people, ideas, and practices that have influenced Tomm's approach, providing an in- depth examination of the method he developed for putting his ideas into practice: Internalized Other Interviewing (IOI). A systemic, relational approach to the practice of postmodern family therapy uses language as a means to create change. Family therapists routinely use different types of questions to ask clients …

Treatments For The Mitigation Of Immunotherapy-Related Neurotoxicities In Patients With Non-Small Cell Lung Cancer, Gautam Chiang

AUCTUS: The Journal of Undergraduate Research and Creative Scholarship

Lung cancer is the most common cancer type worldwide, with one of the highest mortality rates across all cancer types. Cancer immunotherapeutics such as immune checkpoint inhibitors (ICIs) have improved cancer treatment by promoting the body’s natural immune response to tumor development while avoiding toxic effects associated with traditional cytotoxic chemotherapy. However, immunotherapies have been associated with unique toxic effects similar to autoimmune disorders known as immune-related adverse events (irAEs). 4.2% of immunotherapy-treated cancer patients reportedly developed neurological irAEs. In this review, different immunotherapies were studied, including ICIs and mechanism-specific novel therapies, in order to determine a combination therapy to …

Protein Prenylation In The Moss Physcomitrium Patens, Zayna H. Qaissi, Anam F. Ahmed, Katherine V. Brown, Mark P. Running

Undergraduate Arts and Research Showcase

Protein prenylation is the addition of a 15 or 20 carbon lipid to a cysteine near carboxyl terminus of target proteins. Prenylation increases hydrophobicity, which facilitates membrane associations and protein-protein interaction. Protein prenylation is generally conserved among eukaryotes, and mutations in genes that carry out prenylation are lethal in animals and yeast. In plants prenylation mutations are not always lethal, but they do affect development, disease resistance, biofuel production, and drought response, among other processes of agricultural interest. To understand the evolutionary and developmental implications of plant protein prenylation, we used the sequenced, annotated, and translated genome of the moss …