Digital Commons Network^™

In Vivo Optical Metabolic Imaging Of Long-Chain Fatty Acid Uptake In Orthotopic Models Of Triple-Negative Breast Cancer, Megan C. Madonna, Joy E. Duer, Joyce V. Lee, Jeremy Williams, Baris Avsaroglu, Caigang Zhu, Riley Deutsch, Roujia Wang, Brian T. Crouch, Matthew D. Hirschey, Andrei Goga, Nirmala Ramanujam

Biomedical Engineering Faculty Publications

Targeting a tumor’s metabolic dependencies is a clinically actionable therapeutic approach; however, identifying subtypes of tumors likely to respond remains difficult. The use of lipids as a nutrient source is of particular importance, especially in breast cancer. Imaging techniques offer the opportunity to quantify nutrient use in preclinical tumor models to guide development of new drugs that restrict uptake or utilization of these nutrients. We describe a fast and dynamic approach to image fatty acid uptake in vivo and demonstrate its relevance to study both tumor metabolic reprogramming directly, as well as the effectiveness of drugs targeting lipid metabolism. Specifically, …

Assessing The Behavioural Responses Of Small Cetaceans To Unmanned Aerial Vehicles, J. Castro, F. O. Borges, A. Cid, M. I. Laborde, R. Rosa, Heidi C. Pearson

Faculty, Staff, and Students

Unmanned Aerial Vehicles (UAVs), or drones, have recently emerged as a relatively affordable and accessible method for studying wildlife. Vertical Take-off and Landing (VTOL) UAVs are appropriate for morphometric, behavioural, abundance and demographic studies of marine mammals, providing a stable, nonintrusive and highly manoeuvrable platform. Previous studies using VTOL UAVs have been conducted on various marine mammal species, but specific studies regarding behavioural responses to these devices are limited and scarce. The aim of this study was to evaluate the immediate behavioural responses of common (Delphinus delphis) and bottlenose (Tursiops truncatus) dolphins to a VTOL UAV flown at different altitudes. …

Biological Threats Are National Security Risks: Why Covid-19 Should Be A Wake Up Call For Policy Makers, Rep. Eric M. Swalwell, R. Kyle Alagood

Washington and Lee Law Review Online

A national security strategy is the “nation’s plan for the coordinated use of all the instruments of state power—nonmilitary as well as military—to pursue objectives that defend and advance its national interest.” Perhaps the most straightforward national security objective is to protect the country from foreign invasion, but national security involves other objectives that aim to protect people in the United States as well as their values. For example, protecting U.S. elections from foreign interference is a security objective that advances the nation’s interest in democratic governance. The outbreak of a highly contagious disease like COVID‑19 strikes at the core …

Viability And Application Of Mounting Personal Pid Voc Sensors To Small Unmanned Aircraft Systems, Cheryl Lynn Marcham, Scott Burgess, Joseph Cerreta, Patti J. Clark, James P. Solti, Brandon Breault, Joshua G. Marcham

Publications

Using a UAS-mounted sensor to allow for a rapid response to areas that may be difficult to reach or potentially dangerous to human health can increase the situational awareness of first responders of an aircraft crash site through the remote detection, identification, and quantification of airborne hazardous materials. The primary purpose of this research was to evaluate the remote sensing viability and application of integrating existing commercial-off-the-shelf (COTS) sensors with small unmanned aircraft system (UAS) technology to detect potentially hazardous airborne contaminants in emergency leak or spill response situations. By mounting the personal photoionization detector (PID) with volatile organic compound …

Development Of Herbal Green Tea Bags With Osbeckia Octandra L. (Dc.) (Heen Bovitiya) And Evaluation Of The Effect Of Infusion Time And Temperature On Extracted Phytochemicals, P. D. S. A. Silva, S. K. Hettihewa, L. M. Hettihewa

Journal of Innovation in Science, Engineering and Technology

Herbal tea or a tisane is a mixture of dried plant parts used for medicinal purposes. Present study was aimed to develop herbal green tea bags with Osbeckia octandra (Heen bovitiya) leaves predominantly and evaluate the effect of infusion time and temperature on their total phenolic (TP), total flavonoid (TF) contents and in vitro antioxidant activity. Six different tea bags (T1 to T6) were prepared by incorporating dried O. octandra (leaves), Camellia sinensis (leaves), Zingiber officinale (rhizomes), Vanilla planifolia (pods) and Allium sativum (bulbs) in different proportions. Each herbal tea bag was infused at a constant infusion temperature of 100 …

Perceptions Of Sri Lankan Seafarers About The Necessity Of Ratifying The Ballast Water Management Convention In Sri Lanka, I. C. Kulathunga, K. S. A. Weerasena

Journal of Innovation in Science, Engineering and Technology

The International Maritime Organization (IMO) developed and adopted the “International Convention for the Control and Management of Ships' Ballast Water and Sediments” (Ballast Water Management Convention or BWM Convention) in February 2004 to prevent the uptake or discharge of invasive alien species and harmful aquatic organisms and pathogens within ballast water and sediments [5]. The BWM Convention entered into force on the 08th of September 2017. In 2020, 85 countries have ratified the Convention, representing 91. 11 per cent of world merchant shipping tonnage [4]. Yet, Sri Lanka as a Flag State (FS) has still not ratified the BWM Convention …

Alcohol-And-Hiv-Induced Lysosomal Dysfunction Regulates Extracellular Vesicles Secretion In Vitro And In Liver-Humanized Mice, Raghubendra Singh Dagur, Moses New-Aaron, Murali Ganesan, Weimin Wang, Svetlana Romanova, Srivatsan Kidambi, Kusum K. Kharbanda, Larisa Y. Poluektova, Natalia A. Osna

Department of Chemical and Biomolecular Engineering: Faculty Publications

Background: Alcohol abuse is common in people living with HIV-1 and dramatically enhances the severity of HIV-induced liver damage by inducing oxidative stress and lysosomal dysfunction in the liver cells. We hypothesize that the increased release of extracellular vesicles (EVs) in hepatocytes and liver humanized mouse model is linked to lysosome dysfunction. Methods: The study was performed on primary human hepatocytes and human hepatoma RLW_XP-GFP (Huh 7.5 cells stably transfected with CYP2E1 and XPack-GFP) cells and validated on ethanol-fed liver humanized fumarylacetoacetate hydrolase (Fah)^-/-, Rag2^-/-, common cytokine receptor gamma chain knockout (FRG-KO) mice. Cells and …

Illinois State University Salaries Fy2021, Illinois State University

Illinois State University Salaries

Includes two sections: non-tenure track, tenure track, and faculty associate salaries, and administrative professional and civil service salaries.

And We're Rollin' On A River...: The Poetics And Musical Dimensions Of Breaking With Eurocentric Knowledge And Decolonizing Humanity, Hannah Renee Shelton

Electronic Theses and Dissertations Archive

American society to date is wearing a mask. Although claiming to secure rights and liberites for all, American society hides under Eurocentrism's guise which overvalorizes the white maleand undervalorizes minority bodies through reason, space, and place. Therefore, I assert there must be an epistemology which breaks from Eurocentricism. Utilizing poetics as a revalorizing logic, I will ask: How can poetics, as a legitimate source of knowledge, decolonize humanity? Keeping within the American scope, I employ critical race theory and theorists to demonstrate the dangers of employing hegemonic knowledge. I will then utilize poetry, literary devices, jazz, and blues to demonstrate …

Points Of Pride, Georgia Southern University

Points of Pride (2013-2023)

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Adverse Health Effects Of Kratom: An Analysis Of Social Media Data, Abdullah Wahbeh, Tareq Nasralah, Omar El-Gayar, Mohammad A. Al-Ramahi, Ahmed El Noshokaty

Computer Information Systems Faculty Publications (Archived)

This study investigates the adverse healthcare effects associated with the use of kratom. Using machine learning techniques, we analyzed a total of 36,516 users’ posts related to kratom. The results and analysis showed that social media could help identify important insights related to the use of kratom. The sentiment and emotion analyses showed that the kratom experience was negative and largely associated with anger, fear, disgust, and sadness. The results from. topic modeling showed that kratom is associated with a number of healthcare issues such as rashes and itching, urination, constipation, loss of appetite/weight, dry mouth, seizures, nausea, heartburn, dehydration, …

Research Trends In Water Scarcity: A World Perspective, Arikrishnan R Mr, Rajendran N Dr

Library Philosophy and Practice (e-journal)

In this study Water Scarcity involves water crisis, water shortage, water deficit or water stress. Water scarcity plays a big facts or effects on the planet and attracts for several scientist to review it. Therefore, during this research topic explored the new topics and new trends of through the statistics of the journal between 2011-2020 from the attitude of scientometric supported the keyword,” water scarcity”. This paper attempts to analyses the expansion and developments of water scarcity research in world supported the publications output using Scopus database. 7332 records were downloaded from the Scopus database from the category of Environmental …

Palaeozoic Stromatoporoids And Chaetetids Analysed Using Electron Backscatter Diffraction (Ebsd); Implications For Original Mineralogy And Microstructure, Uwe Balthasar, Stephen Kershaw, Silva A-C Da, Barbara Seuss, Maggie Cusack, Kilian Eichenseer, Peter Chung

School of Geography, Earth and Environmental Sciences

No abstract provided.

Protein Roughages For Growing Goats, J. B. Moura Neto, Tadeu V. Voltolini, J. N. Moreira, D. M. Nogueira, R. D. Dos Santos, Luiz G. R. Pereira

IGC Proceedings (1977-2023)

No abstract provided.

Rangeland Management And Livestock Production System In Changthang, Ladakh India, Phunchok

IGC Proceedings (1977-2023)

No abstract provided.

American College Of Physicians Posters, Maine Chapter - 2020

Journal of Maine Medical Center

No abstract provided.

Clinical Utility Of Molecular Profiling In Recurrent Glioblastoma Multiforme, Rebecca P. Bystrom, Pavalan Selvam, Jens Rueter, Honey Reddi, Christine Lu-Emerson

Journal of Maine Medical Center

Introduction: Glioblastoma multiforme (GBM) is the most common and aggressive primary malignant brain tumor found in adults. GBM has limited therapeutic options. Initial tumor sampling establishes the histopathologic diagnosis, identifies prognostic and therapeutic biomarkers, and provides an opportunity for molecular profiling. By contrast, the utility of repeat tumor sampling and molecular profiling in recurrent GBM is not well established.

Clinical Findings: We present a 69-year-old woman with GBM whose tumor recurred after standard treatment with temozolomide (TMZ) and concurrent radiation, followed by adjuvant TMZ. This patient had a methylated O6-methylguanine-DNA methyltransferase (MGMT) promoter, which ordinarily predicts a favorable response to …

Are Nurses Joining The Ride? Equine-Assisted Activities And Therapies Review, Khalid Bandar Almasloukh, Pamela Stewart Fahs

People and Animals: The International Journal of Research and Practice

Background: Equine-assisted activities and therapies (EAAT) is a rapidly growing practice that is described as therapeutic and entertaining. Complementary therapies such as EAAT are gaining acceptance as the health care needs of the population are changing.

Method: This systematic review draws from four databases. The final review included 52 articles.

Purpose: To explain what is known about EAAT and identify literature gaps. Nursing and rural perspectives are included in the analysis and recommendations.

Findings: There are more than eight types of EAAT and different organizations around the world are providing certification for EAAT. Rural communities and organizations may benefit from …

Ovarian Dynamics And Fecundity Regulation In Blueback Herring, Alosa Aestivalis, From The Connecticut River, Us, Foivos Alexandros Mouchlianitis, Eric T. Schultz, Thassya C. Dos Santos Schmidt, Justin P. Davis, Kostas Ganias

EEB Articles

We analyzed ovarian dynamics of anadromous blueback herring, Alosa aestivalis, in Connecticut River with the principal aim of exploring oocyte recruitment and how it shapes the fecundity pattern. We examined the oocyte release strategy and analyzed spawning cyclicity by linking oocyte growth to the degeneration of postovulatory follicles. Females were accordingly classified as pre-spawners, early and late active spawners, and oocyte recruitment intensity was compared among the different spawning phases. Oocyte recruitment occurred continuously and in parallel with spawning activity, a pattern which is diagnostic of indeterminate fecundity. However, both fecundity and oocyte recruitment intensity progressively decreased (tapered) throughout …

Excess Extracellular K+ Causes Inner Hair Cell Ribbon Synapse Degeneration, Hong-Bo Zhao, Yan Zhu, Li-Man Liu

Otolaryngology--Head & Neck Surgery Faculty Publications

Inner hair cell (IHC) ribbon synapses are the first synapse in the auditory system and can be degenerated by noise and aging, thereby leading to hidden hearing loss (HHL) and other hearing disorders. However, the mechanism underlying this cochlear synaptopathy remains unclear. Here, we report that elevation of extracellular K⁺, which is a consequence of noise exposure, could cause IHC ribbon synapse degeneration and swelling. Like intensity dependence in noise-induced cochlear synaptopathy, the K⁺-induced degeneration was dose-dependent, and could be attenuated by BK channel blockers. However, application of glutamate receptor (GluR) agonists caused ribbon swelling but …

Antitumor Property Of Snakes’ Venom Of The Genus Coluber, B.U. Iriskulov, E.A. Rakhmatullaev

Central Asian Journal of Medicine

This article presents data on histological, electron microscopic, and biochemical methods for studying the venom of snakes of the genus Coluber. The effect of Coluber snake venom on antitumor activity was studied. We studied the parameters of T-helper activity and indicators of the chemokine RANTES. The results of the study suggest that the poisons of the Coluber genus have antitumor properties, which is confirmed by the results of the studies.

Metastatic Breast Cancer, Nigora E. Atakhanova, Farrukh Sh. Fayziev, Dilbar M. Almuradova, Dilorom S. Shodmonova

Central Asian Journal of Medicine

Breast cancer is the most common cause of death among women from malignant tumors. Metastatic breast cancer is not currently a curable disease. According to most authors, especially in developing countries, from 50 to 70% of patients already have advanced forms of the disease upon admission (locally common forms, in the form of lesions of regional lymph nodes and distant metastases to various organs). The nature and frequency of distant breast cancer metastases is very diverse. In 40-80% of cases, breast cancer metastasizes to bone. However, it can metastasize other organs and systems, for example, to the liver, lungs, ovaries, …

Effect Of Fractionated And Heat-Treated Wheat Bran On Weight Status In Animal Experiments, G.I. Shaikhova, D.Kh. Ibragimova

Central Asian Journal of Medicine

The role of nutrition in ensuring the health of a modern person is becoming in-creasingly important both at the level of national and international programs. The nutritional factor is essential in the correction of overweight and obesity. Purpose of the study. Influence of the effectiveness of fractionated and heat treated wheat bran. on weight status in animal experiments. Materials and research methods. Sexually mature outbred white rats (weight - 140-150 g). 1.group - control - animals are on a full-fledged general food ra-tion; Group 2 experiment - animals with the introduction of the studied wheat bran into the diet. Euthanasia …

Biological Oceanography Laboratory Ocg 562, Joanna Burkhardt

Library Impact Statements

No abstract provided.

Swk 225: Module 5. Applying Your Eclectic Knowledge: Early Childhood, Middle Childhood And Adolescence [Powerpoint], Erin Stevenson

SWK 225: Human Behavior in the Social Environment OER Collection

Powerpoint slideshow for Module 5 "Applying your Eclectic Knowledge: Early Childhood, Middle Childhood and Adolescence."

Designed around the open access textbook Human Behavior and the Social Environment I, by Dr. Susan Tyler.

Digital Case: 2020 Report, Stephanie Becker

Researchers, Instructors, & Staff Scholarship

Annual report of Case Western Reserve University's Institutional Repository, Digital Case.

Cyclin-Dependent Kinase 1 And Aurora Kinase Choreograph Mitotic Storage And Redistribution Of A Growth Factor Receptor, C. D. Cota, M. S. Dreier , '20, W. Colgan, A. Cha, Twan Sia , '21, Bradley Justin Davidson , '91

Biology Faculty Works

Endosomal trafficking of receptors and associated proteins plays a critical role in signal processing. Until recently, it was thought that trafficking was shut down during cell division. Thus, remarkably, the regulation of trafficking during division remains poorly characterized. Here we delineate the role of mitotic kinases in receptor trafficking during asymmetric division. Targeted perturbations reveal that Cyclin-dependent Kinase 1 (CDK1) and Aurora Kinase promote storage of Fibroblast Growth Factor Receptors (FGFRs) by suppressing endosomal degradation and recycling pathways. As cells progress through metaphase, loss of CDK1 activity permits differential degradation and targeted recycling of stored receptors, leading to asymmetric induction. …

Development Of A Novel Orthotopic Gastric Cancer Mouse Model., Wonyoung Kang, Leigh Maher, Michael Michaud, Seong-Woo Bae, Seongyeong Kim, Hye Seung Lee, Seock-Ah Im, Han-Kwang Yang, Charles Lee

Faculty Research 2021

BACKGROUND: Gastric cancer metastasis is a highly fatal disease with a five-year survival rate of less than 5%. One major obstacle in studying gastric cancer metastasis is the lack of faithful models available. The cancer xenograft mouse models are widely used to elucidate the mechanisms of cancer development and progression. Current procedures for creating cancer xenografts include both heterotopic (i.e., subcutaneous) and orthotopic transplantation methods. Compared to the heterotopic model, the orthotopic model has been shown to be the more clinically relevant design as it enables the development of cancer metastasis. Although there are several methods in use to develop …

Orda Weekly Update, 2021.01.04, Office Of Research Development Administration

ORDA Weekly Update

No abstract provided.

Single-Cell Fluidic Force Microscopy Reveals Stress- Dependent Molecular Interactions In Yeast Mating, Marion Mathelié-Guinlet, Felipe Viela, JéRôMe Dehullu, Sviatlana Filimonava, Jason M. Rauceo, Peter N. Lipke, Yves F. DufrêNe

Publications and Research

Sexual agglutinins of the budding yeast Saccharomyces cerevisiae are proteins mediating cell aggregation during mating. Complementary agglutinins expressed by cells of opposite mating types “a” and “α” bind together to promote agglutination and facilitate fusion of haploid cells. By means of an innovative single-cell manipulation assay combining fluidic force microscopy with force spectroscopy, we unravel the strength of single specific bonds between a- and α-agglutinins (~100 pN) which require pheromone induction. Prolonged cell–cell contact strongly increases adhesion between mating cells, likely resulting from an increased expression of agglutinins. In addition, we highlight the critical role of disulfide bonds of the …