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Protein Kinase D Promotes Airway Epithelial Barrier Dysfunction And Permeability Through Down-Regulation Of Claudin-1, Huachen Gan, Guibo Wang, Qin Hao, Q. Jane Wang, Hua Tang

Cellular and Molecular Biology Faculty Publications and Presentations

At the interface between host and external environment, the airway epithelium serves as a major protective barrier. In the present study we show that protein kinase D (PKD) plays an important role in the formation and integrity of the airway epithelial barrier. Either inhibition of PKD activity or silencing of PKD increased transepithelial electrical resistance (TEER), resulting in a tighter epithelial barrier. Among the three PKD isoforms, PKD3 knockdown was the most efficient one to increase TEER in polarized airway epithelial monolayers. In contrast, overexpression of PKD3 wild type, but not PKD3 kinase-inactive mutant, disrupted the formation of apical intercellular …

The Role Of Neuropilin-1 In Covid-19, Bindu Mayi, Jillian A. Leibowitz, Arden T. Woods, Katherine A. Ammon, Alphonse E. Liu, Aarti Raja

Biology Faculty Articles

Neuropilin-1 (NRP-1), a member of a family of signaling proteins, was shown to serve as an entry factor and potentiate SARS Coronavirus 2 (SARS-CoV-2) infectivity in vitro. This cell surface receptor with its disseminated expression is important in angiogenesis, tumor progression, viral entry, axonal guidance, and immune function. NRP-1 is implicated in several aspects of a SARS-CoV-2 infection including possible spread through the olfactory bulb and into the central nervous system and increased NRP-1 RNA expression in lungs of severe Coronavirus Disease 2019 (COVID-19). Up-regulation of NRP-1 protein in diabetic kidney cells hint at its importance in a population at …

Effect Of Age And Sex On The Discrimination Of Monozygotic Twins Using Cg18562578 Dna Methylation In Saliva, Carla Pierre Louis

Student Theses

DNA methylation is a type of epigenetic modification that impacts gene expression without disturbing the genetic nucleotide sequence. DNA methylation has the potential to be included in the daily forensic analysis because among other uses, it has the potential to be applied to discrimination of monozygotic (MZ) twins that currently cannot be differentiated via forensic DNA profiling. In previous research, our group showed that DNA methylation at the cg18562578 site in chromosome 3 could be used to discriminate MZ twins. Because studies have shown that DNA methylation measures can be influenced by demographic factors such as sex and age; here, …

Genome-Wide Discovery Of Natural Variation In Pre-Mrna Splicing And Prioritising Causal Alternative Splicing To Salt Stress Response In Rice, Huihui Yu, Qian Du, Malachy Campbell, Bin Yu, Harkamal Walia, Chi Zhang

Department of Agronomy and Horticulture: Faculty Publications

Pre-mRNA splicing is an essential step for the regulation of gene expression. In order to specifically capture splicing variants in plants for genome-wide association studies (GWAS), we developed a software tool to quantify and visualise Variations of Splicing in Population (VASP). VASP can quantify splicing variants from short-read RNA-seq datasets and discover genotype-specific splicing (GSS) events, which can be used to prioritise causal pre-mRNA splicing events in GWAS. We applied our method to an RNA-seq dataset with 328 samples from 82 genotypes from a rice diversity panel exposed to optimal and saline growing conditions. In total, 764 significant GSS events …

Genome-Wide Discovery Of Natural Variation In Pre-Mrna Splicing And Prioritising Causal Alternative Splicing To Salt Stress Response In Rice, Huihui Yu, Qian Du, Malachy Campbell, Bin Yu, Harkamal Walia, Chi Zhang

School of Biological Sciences: Faculty Publications

• Pre-mRNA splicing is an essential step for the regulation of gene expression. In order to specifically capture splicing variants in plants for genome-wide association studies (GWAS), we developed a software tool to quantify and visualise Variations of Splicing in Population (VASP).
• VASP can quantify splicing variants from short-read RNA-seq datasets and discover genotype-specific splicing (GSS) events, which can be used to prioritise causal pre-mRNA splicing events in GWAS. We applied our method to an RNA-seq dataset with 328 samples from 82 genotypes from a rice diversity panel exposed to optimal and saline growing conditions.
• In total, 764 significant GSS events …

Complete Genome Sequence Of Geobacter Sp. Strain Feam09, A Moderately Acidophilic Soil Bacterium, Pooja Yadav, Sanjay Antony-Babu, Erin Hayes, Olivia M. Healy, Donald Pan, Wendy H. Yang, Whendee L. Silver, Christopher L. Anderson, Adam Voshall, Samodha C. Fernando, Etsuko N. Moriyama, Joshua R. Herr, Karrie A. Weber

School of Biological Sciences: Faculty Publications

A moderately acidophilic Geobacter sp. strain, FeAm09, was isolated from forest soil. The complete genome sequence is 4,099,068 bp with an average GC content of 61.1%. No plasmids were detected. The genome contains a total of 3,843 genes and 3,608 protein-coding genes, including genes supporting iron and nitrogen biogeochemical cycling.

Heme Oxygenase-1 Affects Cytochrome P450 Function Through The Formation Of Heteromeric Complexes: Interactions Between Cyp1a2 And Heme Oxygenase-1, J. Patrick Connick, James R. Reed, George F. Cawley, Wayne L. Backes

School of Medicine Faculty Publications

Heme oxygenase 1 (HO-1) and the cytochromes P450 (P450s) are endoplasmic reticulum–bound enzymes that rely on the same protein, NADPH-cytochrome P450 reductase (POR), to provide the electrons necessary for substrate metabolism. Although the HO-1 and P450 systems are interconnected owing to their common electron donor, they generally have been studied separately. As the expressions of both HO-1 and P450s are affected by xenobiotic exposure, changes in HO-1 expression can potentially affect P450 function and, conversely, changes in P450 expression can influence HO-1. The goal of this study was to examine interactions between the P450 and HO-1 systems. Using bioluminescence resonance …

Contest Powwow: Sport And Native American Culture, Steven J. Aicinena Dr, Sebahattin Ziyanak

The Qualitative Report

The Native American powwow has served to maintain the culture of North America’s Indigenous peoples since before the arrival of European colonialists. In traditional forms of the powwow, competition is not common whereas contest powwows are characterized by the primacy of competition. We assess similarities and differences between the contest powwow and competitive sport found within the broader American society through in-depth semi-structured interviews with 14 competitive contest powwow dancers. We address a number of questions through the qualitative research process, such as what does the powwow mean to you? What are your primary goals for competing? We analyzed the …

Emotional Dimensions Of Teaching In Elementary Education Preparation, Kathleen M. Crawford, Juliann Sergi Mcbrayer, Katherine Fallon

The Qualitative Report

Student teaching is a pivotal event in teacher education preparation programs, and there is a need to investigate emotions in teaching. This study examined how one elementary program navigated the emotional dimensions of teaching. Findings revealed that the emotional dimensions of student teachers were influenced by individualized factors unique to the teacher; certain emotions were perceived as more acceptable to express; and supervisors needed to support student teachers to manage and respond to the emotional dimensions of teaching. The recommendation is to go beyond the technical and academic aspects of teaching and address the emotional dimensions to best prepare the …

Removal Of Selected Organic Pollutants In Landfill Leachate Using Natural Coagulant From Dillenia Indica Seed Extract, Aziz Ahmed

Student Works (2020-2029)

This study is aimed to identify and characterise novel green coagulant from Dillenia indica seed extracts for the removal of selected persistent organic pollutants (POPs) in landfill leachate using coagulation-flocculation process. The removal efficacy of D. indica seed extracts was compared with commercially available coagulants namely Locust Bean Gum (LBG) and alum. Additionally, it focused on the optimisation of the variables of the coagulation-flocculation process such as coagulants dosage, pH and mixing speed for POPs removal. The functional groups, morphological behaviour and surface area of the dried flocs and samples were analysed using Fourier transform infrared (FTIR), Scanning Electron Microscopy …

Faculty Senate Monthly Packet January 2021, Portland State University Faculty Senate

Faculty Senate Monthly Packets

The January 4, 2021 Monthly packet includes the January agenda and appendices and the Faculty Senate minutes and attachments from the meeting held December 7, 2020.

Group 2i Isochrysidales Produce Characteristic Alkenones Reflecting Sea Ice Distribution, Karen Jiaxi Wang, Yongsong Huang, Markus Majaneva, Simon T. Belt, Sian Liao, Joseph Novak, Tyler R. Kartzinel, Timothy D. Herbert, Nora Richter, Patricia Cabedo-Sanz

School of Geography, Earth and Environmental Sciences

Alkenones are biomarkers produced solely by algae in the order Isochrysidales that have been used to reconstruct sea surface temperature (SST) since the 1980s. However, alkenone-based SST reconstructions in the northern high latitude oceans show significant bias towards warmer temperatures in core-tops, diverge from other SST proxies in down core records, and are often accompanied by anomalously high relative abundance of the C37 tetra-unsaturated methyl alkenone (%C37:4). Elevated %C37:4 is widely interpreted as an indicator of low sea surface salinity from polar water masses, but its biological source has thus far remained elusive. Here we identify a lineage of Isochrysidales …

Microbiome For Mars: Surveying Microbiome Connections To Healthcare With Implications For Long-Duration Human Spaceflight, Virtual Workshop, July 13, 2020, Michael Lapelusa, Dorit Donoviel, Sergio E Branzini, Paul E Carlson, Stephanie Culler, Amrita K Cheema, Rima Kaddurah-Daouk, Denise Kelly, Isabelle De Cremoux, Rob Knight, Rosa Krajmalnik-Brown, Stephen L Mayo, Sarkis K Mazmanian, Emeran A Mayer, Joseph F Petrosino, Keith Garrison

Faculty, Staff and Students Publications

The inaugural "Microbiome for Mars" virtual workshop took place on July 13, 2020. This event assembled leaders in microbiome research and development to discuss their work and how it may relate to long-duration human space travel. The conference focused on surveying current microbiome research, future endeavors, and how this growing field could broadly impact human health and space exploration. This report summarizes each speaker's presentation in the order presented at the workshop.

The Economical Evaluation Of The Grazing Management Project In A Part Of Grasslands In Isfahan Province, A. R. Mirsaidi, M. J. Aghasi

IGC Proceedings (1977-2023)

No abstract provided.

Seasonal Faecal Production Potential Of Livestock Grazing Heterogenous Natural Range And Cropfields Of Semi‐Arid Nigeria, B. S. Malami, P. H. Y. Hiernaux, H. M. Tukur, J. Steinbach

IGC Proceedings (1977-2023)

No abstract provided.

Study On The Characteristics Of Yak Meat In Different Domestic Types And Semi‐Wild Yak In Qinghai Plateau, X. L. Luo, Z. B. Tong, Z. J. Ma, Y. H. Ma

IGC Proceedings (1977-2023)

No abstract provided.

Communicating Scientific Uncertainty In An Age Of Covid-19: An Investigation Into The Use Of Preprints By Digital Media Outlets, Alice Fleerackers, Michelle Riedlinger, Laura Moorhead, Rukhsana Ahmed, Juan Pablo Alperin

Communication Faculty Scholarship

In this article, we investigate the surge in use of COVID-19-related preprints by media outlets. Journalists are a main source of reliable public health information during crises and, until recently, journalists have been reluctant to cover preprints because of the associated scientific uncertainty. Yet, uploads of COVID-19 preprints and their uptake by online media have outstripped that of preprints about any other topic. Using an innovative approach combining altmetrics methods with content analysis, we identified a diversity of outlets covering COVID-19-related preprints during the early months of the pandemic, including specialist medical news outlets, traditional news media outlets, and aggregators. …

The Student Movement Volume 105 Issue 7: Please Pass The Plexiglass: Friends Unite For Shielded Bite, Trevon J. Hunter, Jenae Rogers, Caralynn Chan, Terika Williams, Kristin Ferrer, Gloria Oh, Wambui Karanja, Jessica Rim, Heeyun Oh, Abigail Lee, Celeste Richardson, Megan Napod, Joshua Deonarine, Solana Campbell, Sion Kim

The Student Movement v. 105 (2020-2021)

NEWS

Receiving the COVID-19 Vaccine, Interviewed by TJ Hunter

Andrews University Choral Performs “Celebrating the Light” Concert, Jenae Rogers

AUSA Hosts Sabbath Experience at PMC, Caralynn Chan

Dr. Kizzmekia Shanta Corbett Gives Lecture on the Safety and Effectiveness of COVID-19 mRNA Vaccines, Terika Williams

Loving in the Grey: This Semester’s First In-Person Chapel, Kristin Ferrer

PULSE

Holilday Recap, Gloria Oh

New Year’s Aspirations, Wambui Karanja

The Wellness Column: No Longer Sitting Ducks, Jessica Rim

Winter Break Endeavors, by HeeYun Oh

HUMANS

AU Christmas Album Interview, Interview by Abigail Lee

My Experience in COVID Isolation, Interview by Terika Williams

Spring Semester …

Localizing The Green Energy Revolution, Hannah J. Wiseman

Emory Law Journal Online

The United States is on the verge of a new industrial revolution. Renewable energy could replace more than 60% of our current energy generation infrastructure in fifteen years. This change is critical, yet it risks failure. The renewable generation already built in the United States consists primarily of large-scale projects connected to transmission lines in rural areas. The expansive new generation needed to reduce carbon emissions must also be predominantly large-scale, and rural, for reasons of efficiency. But a revolution that focuses nearly exclusively on “big energy” is likely to encounter obstacles, and it has downsides that could be mitigated …

Leadership Perceptions Of Steam Curriculum Implementation From Educational Leaders In An Elementary Setting, Allyson June Douthit

Theses and Dissertations

The purpose of this qualitative case study was to understand the perceptions of administrators toward the process of STEAM curriculum implementation using a curriculum change lens. The study centers on the qualitative data gathered through the views and experiences of principals who work toward addressing the needs of a future workforce through the STEAM method. Research questions included: (1) What are administrators' perceptions of implementing the STEAM curriculum approach to instruction within an elementary school? (2) What are characteristics of administrators who have guided STEAM curriculum implementation? Data were collected through questionnaires, interviews with individual leaders, and artifacts. The gathering …

Highlights From Studies Presented At The American Heart Association Scientific Session 2020: Navigating New Roads In Prevention, Aliza Hussain, Mahmoud Al Rifai, Dhruv Mahtta, Jing Liu, Vardhmaan Jain, Salim S Virani

Faculty, Staff and Students Publications

PURPOSE OF THE REVIEW: This review highlights late-breaking science presented at the American Heart Association Scientific Session 2020 that demonstrated advancements in preventative cardiology and introduced novel treatment approaches for the management of chronic kidney disease, type 2 diabetes, and/or heart failure.

RECENT FINDINGS: The studies reviewed include clinical trials that assessed the use of omecamtiv in the treatment of heart failure with reduced heart failure (GALACTIC-HF); effects of sotagliflozin in patients with diabetes and recent heart failure exacerbation; cardiovascular outcomes with the use of omega-3 carboxylic acids in patients with high vascular risk and atherogenic dyslipidemia (STRENGTH) and omega-3 …

A New Probe Into The Calculating Method Of The Pasture Ecological Livestock Capability, Hongquan Li, Gang Liu

IGC Proceedings (1977-2023)

No abstract provided.

Effects Of Environmental And Political Framework On Alpine Farming And Its Development In The Entlebuch Unesco Biosphere Reserve Switzerland, Pius Hofstetter, A. Boltshauser, E. Ruoss

IGC Proceedings (1977-2023)

No abstract provided.

Numerical Analysis Of Coupled Systems Of Odes And Applications Toenzymatic Competitive Inhibition By Product, Vinh Quang Mai, Thái Ahn Nhan

Mathematics and Computer Science

Enzymatic inhibition is one of the key regulatory mechanisms in cellular metabolism, especially the enzymatic competitive inhibition by product. This inhibition process helps the cell regulate enzymatic activities. In this paper, we derive a mathematical model describing the enzymatic competitive inhibition by product. The model consists of a coupled system of nonlinear ordinary di erential equations for the species of interest. Using nondimensionalization analysis, a formula for product formation rate for this mechanism is obtained in a transparent manner. Further analysis for this formula yields qualitative insights into the maximal reaction velocity and apparent Michaelis-Menten constant. Integrating the model numerically, …

Ecolunch | Effect Of Head-Starting On Morphology And Bite Force In The Diamondback Terrapin, Feb. 3, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Ecolunch | Hearing Apparatus In Non-Avian Dinosaurs Covid And Data Points Lost Along The Way, Feb 24, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Ecolunch | Investigating Predictors Of Bat Tissue Heavy Metal Levels In The Eastern United States, April 21, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Plant Biology Colloquium | Delaney Gibbs Defends Her Thesis On April 16, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Plant Biology Colloquium | Kelsey Bryant Dissertation Defense, Feb 26, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Plant Biology Colloquium | Lessons From Charismatic Megaflora In Plant Evolution And Hybridization, Feb 19, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.