Digital Commons Network^™

Sars-Cov-2 Pandemic Analytical Overview With Machine Learning Predictability, Anthony Tanaydin, Jingchen Liang, Daniel W. Engels

SMU Data Science Review

Understanding diagnostic tests and examining important features of novel coronavirus (COVID-19) infection are essential steps for controlling the current pandemic of 2020. In this paper, we study the relationship between clinical diagnosis and analytical features of patient blood panels from the US, Mexico, and Brazil. Our analysis confirms that among adults, the risk of severe illness from COVID-19 increases with pre-existing conditions such as diabetes and immunosuppression. Although more than eight months into pandemic, more data have become available to indicate that more young adults were getting infected. In addition, we expand on the definition of COVID-19 test and discuss …

Review Of Innumeracy In The Wild: Misunderstanding And Misusing Numbers By Ellen Peters, Gizem Karaali

Numeracy

Ellen Peters’s new book Innumeracy in the Wild: Misunderstanding and Misusing Numbers (Oxford University Press, 2020) is a whirlwind tour of psychological research on numeracy and its interactions with decision-making. The book is packed full of convincing arguments about the impact of numeracy and innumeracy on people's decisions and life outcomes, piles of supporting evidence and relevant references, and detailed expositions of multitudes of research results. Thus, it can serve the motivated reader well as a comprehensive literature review of psychologically oriented research on numeracy and decision-making.

Water Spines And Networks In G-Quadruplex Structures, Kevin Li , '22, Liliya A. Yatsunyk, S. Neidle

Chemistry & Biochemistry Faculty Works

Quadruplex DNAs can fold into a variety of distinct topologies, depending in part on loop types and orientations of individual strands, as shown by high-resolution crystal and NMR structures. Crystal structures also show associated water molecules. We report here on an analysis of the hydration arrangements around selected folded quadruplex DNAs, which has revealed several prominent features that re-occur in related structures. Many of the primary-sphere water molecules are found in the grooves and loop regions of these structures. At least one groove in anti-parallel and hybrid quadruplex structures is long and narrow and contains an extensive spine of linked …

Special Edition: Principal Investigator Recognition, Lori Gwyn, Cj Smith, Jennifer Cook-Johns

The Source

This is a special edition from the Office of Sponsored Programs honoring the accomplishments of the SWOSU Principal Investigators.

Faculty Senate Agenda, January 11, 2021, Utah State University

Faculty Senate & Faculty Senate Executive Committee

• EPC Monthly Report – December 3, 2020
• HR 385 Code Change (redline-summary-final)
• Council on Teacher Education Annual Report
• Scholarship Advisory Board Annual Report
• Ombudsperson Report
• USU Promotion and Tenure Process Survey
• USU Response to Dixie State University Resolution

Counterfactual-Based Nudging And Signaling Promote More Efficient Coordination During Group Tasks, Ion Juvina, Alexander R. Hough, Kevin O'Neill

Psychology Faculty Publications

Groups of people often find it challenging to coordinate on a single choice or option. Even when coordination is achieved, it may be inefficient because better outcomes were possible. Numerous researchers attempted to address this coordination problem with various manipulations ranging in complexity and generalizability, but results were mixed. Here, we use a more parsimonious and generalizable method – counterfactuals – to nudge (i.e. indirectly guide and allow for free choice) individuals towards choosing options that are more likely to result in efficient coordination. We used a modified version of an existing coordination game, the minimum effort game (MEG), where …

Epihet For Intra-Tumoral Epigenetic Heterogeneity Analysis And Visualization., Xiaowen Chen, Haitham Ashoor, Ryan Musich, Jiahui Wang, Mingsheng Zhang, Chao Zhang, Mingyang Lu, Sheng Li

Faculty Research 2021

Intra-tumoral epigenetic heterogeneity is an indicator of tumor population fitness and is linked to the deregulation of transcription. However, there is no published computational tool to automate the measurement of intra-tumoral epigenetic allelic heterogeneity. We developed an R/Bioconductor package, epihet, to calculate the intra-tumoral epigenetic heterogeneity and to perform differential epigenetic heterogeneity analysis. Furthermore, epihet can implement a biological network analysis workflow for transforming cancer-specific differential epigenetic heterogeneity loci into cancer-related biological function and clinical biomarkers. Finally, we demonstrated epihet utility on acute myeloid leukemia. We found statistically significant differential epigenetic heterogeneity (DEH) loci compared to normal controls and constructed …

A Randomized Control Trial To Test A Peer Support Group Approach For Reducing Social Isolation And Depression Among Female Mexican Immigrants, Janet Page-Reeves, Cristina Murray-Krezan, Lidia Regino, Jackie Perez, Molly Bleecker, Daniel Perez, Bill Wagner, Susan Tigert, Elaine L. Bearer, Cathleen E. Willging

Pathology Research and Scholarship

BACKGROUND: Female Mexican Immigrants (FMIs) experience high rates of depression compared with other populations. For this population, depression is often exacerbated by social isolation associated with the experience of immigration. Aim 1. To measure whether a culturally situated peer group intervention will reduce depression and stress associated with the experience of immigration. Aim 2. To test whether an intervention using a "women's funds of knowledge" approach results in improved resilience, knowledge and empowerment. Aim 3. To investigate whether a culturally situated peer group intervention using a women's funds of knowledge approach can give participants a sense and experience of social …

A Systematic Review Of The Nickel Content Of The Normal Human Prostate Gland, Vladimir Zaichick

Health Sciences

Introduction: The prostate gland is subject to various disorders. The etiology and pathogenesis of these diseases remain not well understood. Moreover, despite technological advancements, the differential diagnosis of prostate disorders has become progressively more complex and controversial. It was suggested that the nickel (Ni) level in prostatic tissue plays an important role in prostatic carcinogenesis and its measurement may be useful as a cancer biomarker. These suggestions promoted more detailed studies of the Ni content in the prostatic tissue of healthy subjects. Materials and methods: The present study is evaluated by systematic analysis of the published data for Ni content …

Affective Dependence: From Pathological Affectivity To Personality Disorders: Definitions, Clinical Contexts, Neurobiological Profiles And Clinical Treatments, Giulio Perrotta

Health Sciences

Starting from the general concept of affectivity, the present work focuses on the clinical, neurobiological, and dysfunctional aspects of the morbid condition, when dysfunction gradually becomes first an affective addiction and then a symptom of a psychopathological personality picture, thus suggesting a multidimensional treatment. From effective dependence to personality disorders, about the dynamics of human bonding, to the implications determined by the attachment theory, trying to demonstrate that the clinical category of affective dependence cannot be considered simply a form of behavioral dependence, as erroneously done in the last decade, but as a symptom of a psychopathological manifestation of personality, …

Arthropods Are Not Declining But Are Responsive To Disturbance In The Luquillo Experimental Forest, Puerto Rico, Timothy D. Schowalter, Manoj Pandey, Steven J. Presley, Michael R. Willig, Jess K. Zimmerman

Faculty Publications

A number of recent studies have documented long-term declines in abundances of important arthropod groups, primarily in Europe and North America. These declines are generally attributed to habitat loss, but a recent study [B.C. Lister, A. Garcia, Proc. Natl. Acad. Sci. USA 115, E10397-E10406 (2018)] from the Luquillo Experimental Forest (LEF) in Puerto Rico attributed declines to global warming. We analyze arthropod data from the LEF to evaluate long-term trends within the context of hurricane-induced disturbance, secondary succession, and temporal variation in temperature. Our analyses demonstrate that responses to hurricane-induced disturbance and ensuing succession were the primary factors that affected …

Orda Weekly Update, 2021.01.11, Office Of Research Development Administration

ORDA Weekly Update

No abstract provided.

Clinical Evaluation Of Respiratory Rate Measurements On Copd (Male) Patients Using Wearable Inkjet-Printed Sensor, Ala'aldeen Al-Halhouli, Loiy Al-Ghussain, Osama Khallouf, Alexander Rabadi, Jafar Alawadi, Haipeng Liu, Khaled Al Oweidat, Fei Chen, Dingchang Zheng

Mechanical Engineering Graduate Research

Introduction: Chronic Obstructive Pulmonary Disease (COPD) is a progressive disease that causes long-term breathing problems. The reliable monitoring of respiratory rate (RR) is very important for the treatment and management of COPD. Based on inkjet printing technology, we have developed a stretchable and wearable sensor that can accurately measure RR on normal subjects. Currently, there is a lack of comprehensive evaluation of stretchable sensors in the monitoring of RR on COPD patients. We aimed to investigate the measurement accuracy of our sensor on COPD patients. Methodology: Thirty-five patients (Mean ± SD of age: 55.25 ± 13.76 years) in different stages …

Returning To Where It All Started, Brooks Payette

UNH Today Archive

No abstract provided.

Specification Of The Patterning Of A Ductal Tree During Branching Morphogenesis Of The Submandibular Gland., Janice L Walker, Weihao Wang, Edith Lin, Alison Romisher, Meghan P Bouchie, Brigid Bleaken, A Sue Menko, Maria A Kukuruzinska

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

The development of ductal structures during branching morphogenesis relies on signals that specify ductal progenitors to set up a pattern for the ductal network. Here, we identify cellular asymmetries defined by the F-actin cytoskeleton and the cell adhesion protein ZO-1 as the earliest determinants of duct specification in the embryonic submandibular gland (SMG). Apical polarity protein aPKCζ is then recruited to the sites of asymmetry in a ZO-1-dependent manner and collaborates with ROCK signaling to set up apical-basal polarity of ductal progenitors and further define the path of duct specification. Moreover, the motor protein myosin IIB, a mediator of mechanical …

Health Access Of Women In Provincial Correctional Institutions, Shamiram Zendo, Lorie Donelle Phd, Rn, Fcan, Lilian Magalhaes

Publications

Historically, there has been a disparity between men and women rates of incarceration, even though there has been a significant increase in the number of women imprisoned over the past 20 years, globally. Women have unique health care needs that are often not adequately addressed within the correctional institutions in which they are held. The focus of this study was to explore women's experiences when accessing health services within Canadian provincial correctional institutions. Narrative inquiry was used to investigate the life stories of five women who accessed health care in provincial correctional institutions. A total of two storylines and five …

Week Of January 11, 2021, New York Medical College

InTouch

• D.P.T. Class of 2021 TeamGO Sends Humanitarian Aid to Dominica
• Bench-to-Bedside Seminar Series Focuses on Data, Personalization and Digital Health
• Ninth Symposium on COVID-19 Set for January 12
• Chancellor Halperin Shares his Thoughts on the Medical Ethics of Vaccine Distribution

Growing More Than Algae, Beth Potier

UNH Today Archive

No abstract provided.

State V. Hunnicutt Appellant's Brief Dckt. 48038

Not Reported

No abstract provided.

College Student Suicidal Behavior: Exploring Faculty Willingness To Intervene, Rikki Turner

Theses and Dissertations

A quantitative cross-sectional study was conducted to investigate what factors contribute to faculty members’ willingness to intervene with suicidal students. An online survey was administered to faculty (N = 281) in order to collect data for quantitative analysis. Independent variables included gender, faculty discipline as defined by BIGLAN categories, attitudes about intervention (effect on student and effect on participant), subjective norms, and perceived behavior control (express care and utilize outside resources). Dependent variables included intent to intervene expressing care, utilizing outside resource, and utilizing emergency services. A confirmatory factor analysis was conducted to confirm that this population fit the model …

Similarity Measure Selection And Optimization For E-Commerce Product Matching, Maryetta Morris

Theses and Dissertations

Since its birth in 1979, e-commerce has grown to become a generation-defining phenomenon. There are millions of platforms from which online transactions can be made, and billions of products available for purchase. As these numbers continue to grow, there is an increased need to exchange, process, and store data about these products. There are also services such as review aggregators and price comparison sites that rely on collecting and integrating data from all over the web. When combining data from multiple sources, it is important to be able to identify which references refer to the same real-life product. Product matching, …

Armed Conflicts In Outer Space: Which Law Applies?, Frans G. Von Der Dunk

International Law Studies

So far, outer space has merely become involved in terrestrial armed conflicts as part of the supportive infrastructure for military activities. Unfortunately, the risk that this changes is considerably growing, and it can no longer be excluded that (armed) force will become used in outer space, either directed towards Earth or within outer space itself.

This raises serious issues in the legal context, where space law so far has been premised on the hope that armed conflicts in outer space could be avoided whereas the law of armed conflict was not required so far to deal with the use of …

Parental Buffering In The Context Of Poverty: Positive Parenting Behaviors Differentiate Young Children's Stress Reactivity Profiles, Samantha M. Brown, Lisa J. Schlueter, Eliana Hurwich-Reiss, Julia Dmitrieva, Elly Miles, Sarah Enos Watamura

Psychology: Faculty Scholarship

Experiencing poverty increases vulnerability for dysregulated hypothalamic–pituitary–adrenal (HPA) axis functioning and compromises long-term health. Positive parenting buffers children from HPA axis reactivity, yet this has primarily been documented among families not experiencing poverty. We tested the theorized power of positive parenting in 124 parent–child dyads recruited from Early Head Start (Mage = 25.21 months) by examining child cortisol trajectories using five samples collected across a standardized stress paradigm. Piecewise latent growth models revealed that positive parenting buffered children's stress responses when controlling for time of day, last stress task completed, and demographics. Positive parenting also interacted with income such that …

Shear Stress Associated With Cardiopulmonary Bypass Induces Expression Of Inflammatory Cytokines And Necroptosis In Monocytes., Lan N. Tu, Lance Hsieh, Masaki Kajimoto, Kevin Charette, Nataliya Kibiryeva, Adriana Forero, Sarah Hampson, Jennifer A. Marshall, James O'Brien, Marta Scatena, Michael A. Portman, Ram Savan, Chris Benner, Alberto Aliseda, Muhammad Nuri, Douglas Bittel, Peter Pastuzsko, Vishal Nigam

Manuscripts, Articles, Book Chapters and Other Papers

Cardiopulmonary bypass (CPB) is required during most cardiac surgeries. CBP drives systemic inflammation and multiorgan dysfunction that is especially severe in neonatal patients. Limited understanding of molecular mechanisms underlying CPB-associated inflammation presents a significant barrier to improve clinical outcomes. To better understand these clinical issues, we performed mRNA sequencing on total circulating leukocytes from neonatal patients undergoing CPB. Our data identify myeloid cells, particularly monocytes, as the major cell type driving transcriptional responses to CPB. Furthermore, IL-8 and TNF-α were inflammatory cytokines robustly upregulated in leukocytes from both patients and piglets exposed to CPB. To delineate the molecular mechanism, we …

A Case Of Diastematomyelia Presenting With Minimal Neurologic Deficits In A Middle-Aged Patient, Gabriella Mamo, Rishu Batra, Jeffrey Steinig

Transitional Year Resident Research

Diastematomyelia is a rare congenital deformity of the spine in which the spinal cord is split into two hemicords along the sagittal plane. This condition belongs to the group of spinal dysraphisms, is more common in females, and is usually diagnosed prenatally or during childhood; rarely is it diagnosed in adults. We report a male patient in his 50s in which diastematomyelia of the thoracic spine was incidentally encountered after receiving a CT scan of the chest for shortness of breath. Although most patients with this condition are symptomatic, the patient did not display any significant acute neurological complaints at …

Covid-19 Pandemic In Brazil: Clinical Manifestation And Effect Of Comorbidities On Outcomes Of Hospitalized Sari Cases, Mario Keko, Karl E. Peace

Biostatistics, Epidemiology & Environmental Health Sciences: Faculty Publications

Hospitalized SARI cases of 2020 reported to the Ministry of Health of Brazil through the SIVEP Gripe system are subject to our analysis. They are classified as COVID-19 and non-COVID-19 and clinical manifestations and comorbidities are reported for each group. The time trend in the number of cases reported in 2020 is compared to the previous year and the performance of the PCR test is explored in each group. The proportion of death is reported among different subgroups of the patients by epidemiological week. Logistic and Poisson regression models are used to check the effect of comorbidities on clinical outcomes.

Central Nervous System Intravascular Lymphoma Leading To Rapidly Progressive Dementia, Christie G Turin, Kevin Ting, Anthony Bradshaw, S Richard Dunham, Karen Nunez-Wallace, Shital M Patel, Priti Dangayach, Stephanie Holdener, Weei-Chin Lin

Faculty, Staff and Students Publications

Intravascular lymphoma is an uncommon subtype of B-cell lymphoma with neoplastic cells limited to the lumen of small blood vessels. We report a case of a 52-year-old man who presented with constitutional symptoms and rapidly progressive dementia. He was found to have diffuse leptomeningeal and faint parenchymal enhancement on magnetic resonance imaging and was subsequently diagnosed with intravascular lymphoma following a brain biopsy. He responded remarkably well to systemic and intrathecal chemotherapy. The diagnosis and treatment of intravascular lymphoma have been guided by a few case reports and are largely based on expert opinion.

Prenatal Maternal Psychological Distress And Fetal Developmental Trajectories: Associations With Infant Temperament, Mariann A. Howland, Curt A. Sandman, Elyssia Poggi Davis, Laura M. Glynn

Psychology Faculty Articles and Research

Associations between prenatal maternal psychological distress and offspring developmental outcomes are well documented, yet relatively little research has examined links between maternal distress and development in utero, prior to postpartum influences. Fetal heart rate (FHR) parameters are established indices of central and autonomic nervous system maturation and function which demonstrate continuity with postnatal outcomes. This prospective, longitudinal study of 149 maternal–fetal pairs evaluated associations between prenatal maternal distress, FHR parameters, and dimensions of infant temperament. Women reported their symptoms of psychological distress at five prenatal visits, and FHR monitoring was conducted at the last three visits. Maternal report of infant …

Zika Virus Oncolytic Activity Requires Cd8+ T Cells And Is Boosted By Immune Checkpoint Blockade, Sharmila Nair, Luciano Mazzoccoli, Arijita Jash, Jennifer Govero, Sachendra S Bais, Tong Hu, Camila R Fontes-Garfias, Chao Shan, Hideho Okada, Sujan Shresta, Jeremy N Rich, Pei-Yong Shi, Michael S Diamond, Milan G Chheda

Open Access Publications

Glioblastoma multiforme (GBM) is a fatal human cancer in part because GBM stem cells are resistant to therapy and recurrence is inevitable. Previously, we demonstrated Zika virus (ZIKV) targets GBM stem cells and prevents death of mice with gliomas. Here, we evaluated the immunological basis of ZIKV-mediated protection against GBM. Introduction of ZIKV into the brain tumor increased recruitment of CD8+ T and myeloid cells to the tumor microenvironment. CD8+ T cells were required for ZIKV-dependent tumor clearance because survival benefits were lost with CD8+ T cell depletion. Moreover, while anti-PD-1 antibody monotherapy moderately improved tumor survival, when coadministered with …

A Study On Ningxia Desert Grassland (Stipa Breviflora) Utilization, Kechang Li, Xin Wu, Jinhua Wang, Zhao Yu

IGC Proceedings (1977-2023)

No abstract provided.