Digital Commons Network^™

Genetic Approach To Elucidate The Role Of Cyclophilin D In Traumatic Brain Injury Pathology, Ryan D. Readnower, W. Brad Hubbard, Olivia J. Kalimon, James W. Geddes, Patrick G. Sullivan

Spinal Cord and Brain Injury Research Center Faculty Publications

Cyclophilin D (CypD) has been shown to play a critical role in mitochondrial permeability transition pore (mPTP) opening and the subsequent cell death cascade. Studies consistently demonstrate that mitochondrial dysfunction, including mitochondrial calcium overload and mPTP opening, is essential to the pathobiology of cell death after a traumatic brain injury (TBI). CypD inhibitors, such as cyclosporin A (CsA) or NIM811, administered following TBI, are neuroprotective and quell neurological deficits. However, some pharmacological inhibitors of CypD have multiple biological targets and, as such, do not directly implicate a role for CypD in arbitrating cell death after TBI. Here, we reviewed the …

The Association Of Circulating Amylin With Β-Amyloid In Familial Alzheimer's Disease, Han Gia Ly, Nirmal Verma, Savita Sharma, Deepak Kotiya, Sanda Despa, Erin L. Abner, Peter T. Nelson, Gregory A. Jicha, Donna M. Wilcock, Larry B. Goldstein, Rita Guerreiro, José Brás, Angela J. Hanson, Suzanne Craft, Andrew J. Murray, Geert Jan Biessels, Claire Troakes, Henrik Zetterberg, John Hardy, Tammaryn Lashley, Alzheimer’S Disease Exome Sequencing Group, Florin Despa

Pharmacology and Nutritional Sciences Faculty Publications

Introduction

This study assessed the hypothesis that circulating human amylin (amyloid‐forming) cross‐seeds with amyloid beta (Aβ) in early Alzheimer's disease (AD).

Methods

Evidence of amylin‐AD pathology interaction was tested in brains of 31 familial AD mutation carriers and 20 cognitively unaffected individuals, in cerebrospinal fluid (CSF) (98 diseased and 117 control samples) and in genetic databases. For functional testing, we genetically manipulated amylin secretion in APP/PS1 and non‐APP/PS1 rats.

Results

Amylin‐Aβ cross‐seeding was identified in AD brains. High CSF amylin levels were associated with decreased CSF Aβ42 concentrations. AD risk and amylin gene are not correlated. Suppressed amylin secretion protected …

Examining Adverse Childhood Experiences Among Native American Persons In A Nationally Representative Sample: Differences Among Racial/Ethnic Groups And Race/Ethnicity-Sex Dyads, Tara Richards, Joseph A. Schwartz, Emily M. Wright

Criminology and Criminal Justice Faculty Publications

Background

Existing research using nationally representative samples has provided valuable information regarding the prevalence and context of childhood adversity, but Native American persons have largely been absent from these studies.

Objective

We examined adverse childhood experiences (ACEs) among persons identifying as White, Black, Asian, Hispanic, and Native American in the NESARC, a longitudinal study (Wave 1: 2001–2002; Wave 2: 2004–2005) using a nationally representative sample from the United States.

Methods

Means tests and negative binomial regression were used to examine the prevalence and variety of ACEs across racial/ethnic groups and race/ethnicity-sex dyads.

Results

Native American persons reported the greatest average …

Molecular Dynamic Simulation Of Protein Devices And The Parameterization Of Azides And Alkynes For Use In Unnatural Amino Acid Models, Addison Kyle Smith

Theses and Dissertations

Proteins that have been modified by attaching them to a surface or to a polyethylene glycol (PEG) molecule can see many uses in therapeutics and diagnostics -- these unique proteins are called protein devices. Current techniques can perform these functionalizations at a specific residue on the protein, but what remains is identifying what happens to protein structure when mutated, and where to perform the attachment. Both of these issues can be examined using molecular dynamic (MD) simulations. Currently, simulations of the unnatural amino acid (uAA) mutations necessary for protein device functionalization cannot be executed, and full-protein screens of all possible …

Experimental Pharmacotherapies In Models Of Alcohol Addiction, Mousumi Akter Sumi

Theses and Dissertations

The USA faces $220 billion economic loss and eighty thousand deaths per year due to alcohol abuse while affecting more than 15 million people, making it the third largest life-style related cause of death. The U.S. FDA has approved four medications namely, disulfiram, acamprosate, oral naltrexone, and injectable long-acting naltrexone. These existing drugs are trashed with side effects, have a low success rate, indicating a demand for new potential drugs. We studied the effects of the CB1 negative allosteric modulator, PSNCBAM-1, and the dopamine D4 receptor antagonist, L-745,870 in mouse models of alcohol addiction. PSNCBAM-1 did not significantly reduce CPP …

Distinct Mechanisms Control Genome Recognition By P53 At Its Target Genes Linked To Different Cell Fates., Marina Farkas, Hideharu Hashimoto, Yingtao Bi, Ramana V Davuluri, Lois Resnick-Silverman, James J. Manfredi, Erik W. Debler, Steven B. Mcmahon

Department of Biochemistry and Molecular Biology Faculty Papers

The tumor suppressor p53 integrates stress response pathways by selectively engaging one of several potential transcriptomes, thereby triggering cell fate decisions (e.g., cell cycle arrest, apoptosis). Foundational to this process is the binding of tetrameric p53 to 20-bp response elements (REs) in the genome (RRRCWWGYYYN_0-13RRRCWWGYYY). In general, REs at cell cycle arrest targets (e.g. p21) are of higher affinity than those at apoptosis targets (e.g., BAX). However, the RE sequence code underlying selectivity remains undeciphered. Here, we identify molecular mechanisms mediating p53 binding to high- and low-affinity REs by showing that key determinants of the code are embedded …

Intervention Of Climate‐Smart Practices In Wheat Under Rice‐ Wheat Cropping System In Nepal, Jamma Jaya Gairhe, Mandeep Adhikari, Deepak Ghimire, Arun Kjatri-Chhetri, Dinesh Panday

Department of Agronomy and Horticulture: Faculty Publications

Besides a proper agronomic management followed by Nepalese farmers, wheat (Triticum aestivum L.) production has been severely affected by changing climate. There are many interventions, including climate‐smart practices, to cope with this situation and possibly enhance crop and soil productivity. Field experiments were set up in a randomized complete block design with six treatments (TRT) with four replications in three locations (LOC) during wheat‐growing seasons in Nepal from 2014 to 2016. Treatments included (i) Controlled Practice (CP), (ii) Improved Low (IL), (iii) Improved High (IH), (iv) Climate Smart Agriculture Low (CSAL), (v) Climate Smart Agriculture Medium (CSAM), and (vi) Climate …

Review Of Recent Developments Of International Interdisciplinary Research In Philosophy And Science, Chuang Liu, Kefu Zhu

Bulletin of Chinese Academy of Sciences (Chinese Version)

In this article we discuss a selected sample of interdisciplinary researches between philosophy and science in the forefront of high energy physics, science of intelligence, biological science, and social science. We discuss both the ideas and the important international institutions and figures.

Philosophy And Physics Meet In Quantum World, Liuxiang Hao

Bulletin of Chinese Academy of Sciences (Chinese Version)

On the basis of discussion about the ontological status of quantum state in quantum mechanics, the properties of particle in the quantum theory of fields and the problem of time in the canonical quantum gravity, the author argues that the hard core of any physical theory consists of some metaphysical assumptions. The author points out that from the perspective of the history and philosophy of science, the relationship between philosophy and physics is in some way analogous of that between mathematics and physics, so the reunion of philosophy and physics will help us to clarify and even solve those fundamental …

Several Key Points In Territorial Ecological Restoration, Bojie Fu

Bulletin of Chinese Academy of Sciences (Chinese Version)

The coupled Human-Natural System thinking is considered as an important theoretical basis for territorial ecological restoration. The relationships between ecological space, production space, and living space show three evolution stages in territorial governance: coordinated arrangement, systematic governance, and human-nature harmony. In this regard, coupled Human-Natural System research is necessary to set the perspectives of coupling indicators, coupling hierarchies, coupling effects and coupling models to identify the primary evaluation indicators, delineate hierarchical nested regions, decouple the spatio-temporal relationship of socialecological effects, and develop human-natural coupling models, so as to systematically support the territorial ecological restoration and facilitate the national and regional …

Review And Analysis On History Of Establishing And Operating Universities By Chinese Academy Of Sciences, Nianning Chen, Yong Xie

Bulletin of Chinese Academy of Sciences (Chinese Version)

Since set up in 1949, Chinese Academy of Sciences (CAS) has established and operated several universities to meet the need of the state and the academy. It is a history with pains and gains. Today, a large number of professional talents have been trained and graduated from CAS. CAS takes a pioneer role in exploring the new way for the development of Chinese higher education in integrating scientific research and training, and promoting Chinese universities' academic levels.

Thoughts On Future Development Of Field Observation And Research Network Of Chinese Academy Of Sciences, Ping Yang

Bulletin of Chinese Academy of Sciences (Chinese Version)

Acting as a distributed field science and technology infrastructure, the field station network of Chinese Academy of Sciences (CAS) has evolved to be an important scientific and technological infrastructure with comparative advantage in China. Especially, the Chinese Ecosystem Research Network (CERN) leads the construction and development of the national ecosystem station network. The top-level design and overall layout have been paid more attention in the construction of the field scientific observation and research network of CAS during the 14th Five-Year Plan, and the orientation and objectives of the field station network is highlighted further. The main tasks include improving the …

Containment Of Procedure-Associated Aerosols By An Extractor Tent:: Effect On Nebulized Drug Particle Dispersal, M. Fennelly, J. Keane, L. Dolan, B. J. Plant, D. J. O'Connor, J. R. Sodeau, M. B. Prentice

Research Outputs: 2025-Present

Background: Several medical procedures involving the respiratory tract are considered as ‘aerosol-generating procedures’. Aerosols from these procedures may be inhaled by bystanders, and there are consequent concerns regarding the transmission of infection or, specific to nebulized therapy, secondary drug exposure.

Aim: To assess the efficacy of a proprietary high-efficiency-particulate-air-filtering extractor tent on reducing the aerosol dispersal of nebulized bronchodilator drugs.

Methods: The study was conducted in an unoccupied outpatient room at St. James's Hospital, Dublin, Ireland. A novel real-time, fluorescent particle counter, the Wideband Integrated Bioaerosol Sensor (WIBS), monitored room air continuously for 3 h. Baseline airborne particle count and …

Montana Kaimin, January 20, 2021, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

High-Resolution, Large-Scale Laboratory Measurements Of A Sandy Beach And Dynamic Cobble Berm Revetment, Chris E. Blenkinsopp, Paul M. Bayle, Daniel C. Conley, Gerd Masselink, Emily Gulson, Isabel Kelly, Rafael Almar, Ian L. Turner, Tom E. Baldock, Tomas Beuzen, Robert T. Mccall, Huub Rijper, Ad Reniers, Peter Troch, David Gallach-Sanchez, Alan J. Hunter, Oscar Bryan, Gwyn Hennessey, Peter Ganderton, Marion Tissier, Matthias Kudella, Stefan Schimmels

School of Biological and Marine Sciences

High quality laboratory measurements of nearshore waves and morphology change at, or near prototype-scale are essential to support new understanding of coastal processes and enable the development and validation of predictive models. The DynaRev experiment was completed at the GWK large wave flume over 8 weeks during 2017 to investigate the response of a sandy beach to water level rise and varying wave conditions with and without a dynamic cobble berm revetment, as well as the resilience of the revetment itself. A large array of instrumentation was used throughout the experiment to capture: (1) wave transformation from intermediate water depths …

Synthesis Of Ultra‐Fine Co 1‐(X+Y) Ni X Zn Y Fe 2 O 4 Ferrite Nanoparticles: Customizing Magnetic Properties, S Khorshidian, B Vaseghi, G Rezaei, D Jenkins, N Kumar, A Rajan

School of Engineering, Computing and Mathematics

Synthesis of ultrafine Co₁-(x+y)NixZnyFe₂O₄ magnetic nanoparticles with different chemical compositions is essential to study the magnetic fluid hyperthermia (MFH) as a treatment in which the superparamagnetic behaviour of materials is beneficial. In this paper, Co₁-(x+y)NiZnyFe₂O₄ magnetic nanoparticles with different x and y amounts were synthesized to find out a tuning pattern for magnetic properties, especially anisotropy constant to gain the best heating efficiency. We proved that the co-presence of ions will greatly affect the magnetic performance of our superparamagnetic nanoparticles in which Co₀.₅₉Zn₀.₄₁Fe₂O₄ for values of x = 0.00 and y = 0.41 exhibits the highest magnetic anisotropy constant after …

Food Insecurity Experiences Of Idaho Head Start Families, Sherry Deiter, Yitza A. Arcelay-Rojas

Journal of Social, Behavioral, and Health Sciences

Using the social-ecological model, this basic interpretive qualitative study sought to examine the phenomenon of food insecurity among Idaho Head Start enrolled families, focusing on barriers and deterrents to accessing available nutrition assistance programs. A total of 11 interviews were conducted with parents who had children enrolled in five Idaho Head Start programs. The data were coded and analyzed and are reflective of how individual, interpersonal, community, and organizational levels factors are reflected in participants’ decisions to access available nutrition assistance programs. Participants reported feelings of stigma and shame and transportation concerns as individual barriers as well as the interpersonal …

A Multi-Modal Approach To Measuring Particulate Iron Speciation In Buoyant Hydrothermal Plumes, Brandy D. Stewart, Jeffry V. Sorensen, Kathleen Wendt, Jason B. Sylvan, Christopher R. German, Karthik Anantharaman, Gregory J. Dick, John A. Breier, Brandy M. Toner

School of Earth, Environmental, & Marine Sciences Faculty Publications

Processes active within buoyant hydrothermal plumes are expected to modulate the flux of elements, such as Fe, to the deep ocean; however, they are yet to be described in a comprehensive manner through observations or models. In this study, we compare observed particulate Fe (pFe) speciation with thermodynamic (equilibrium) reaction path modeling for three vent fields in the Eastern Lau Spreading Center (ELSC). At each site, particles were collected from the buoyant rising portion of hydrothermal plumes using in situ filtration with a Remotely Operated Vehicle. Filter bound particles were analyzed by synchrotron micro-probe X-ray fluorescence mapping (XRF), X-ray diffraction …

Founders' Day, 2021, S. Georgia Nugent

Remarks and Messages

No abstract provided.

Identification Of 3-Chymotrypsin Like Protease (3clpro) Inhibitors As Potential Anti-Sars-Cov-2 Agents., Vicky Mody, Joanna Ho, Savannah Wills, Ahmed Mawri, Latasha Lawson, Maximilian C C J C Ebert, Guillaume M Fortin, Srujana Rayalam, Shashidharamurthy Taval

PCOM Scholarly Works

Emerging outbreak of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is a major threat to public health. The morbidity is increasing due to lack of SARS-CoV-2 specific drugs. Herein, we have identified potential drugs that target the 3-chymotrypsin like protease (3CLpro), the main protease that is pivotal for the replication of SARS-CoV-2. Computational molecular modeling was used to screen 3987 FDA approved drugs, and 47 drugs were selected to study their inhibitory effects on SARS-CoV-2 specific 3CLpro enzyme in vitro. Our results indicate that boceprevir, ombitasvir, paritaprevir, tipranavir, ivermectin, and micafungin exhibited inhibitory effect towards 3CLpro enzymatic activity. The 100 …

Naturalistic Language Input Is Associated With Resting-State Functional Connectivity In Infancy, Lucy S. King, M. Catalina Camacho, David F. Montez, Kathryn L. Humphreys, Ian H. Gotlib

Open Access Publications

The quantity and quality of the language input that infants receive from their caregivers affects their future language abilities; however, it is unclear how variation in this input relates to preverbal brain circuitry. The current study investigated the relation between naturalistic language input and the functional connectivity (FC) of language networks in human infancy using resting-state functional magnetic resonance imaging (rsfMRI). We recorded the naturalistic language environments of five- to eight-month-old male and female infants using the Linguistic ENvironment Analysis (LENA) system and measured the quantity and consistency of their exposure to adult words (AWs) and adult-infant conversational turns (CTs). …

Evaluating The Trauma-Informed Program For Promoting Success, Jessica Foley

Theses and Dissertations

Research has shown trauma-informed care in schools is effective in reducing the impact of trauma on children, as well as bolstering future success in those who are at-risk for experiencing trauma. Improving students school climate, emotion regulation strategies, learning behaviors, and friendships in middle school students is effective in preventing the impact of trauma. There is limited research to address implementation of trauma-informed, group-based services in middle schools. In this study, a group-based intervention targeted towards middle school students who are at-risk for trauma will be examined. 54 middle school students in grades 6-8 will be participating in the Trauma-Informed …

The Effect Innovation Of Information Technology, Product, Work, And Service Toward Development Performance Academic Business Laboratory In Indonesia, Ilham M, Tanti Handriana, Fendy Suhariadi

Library Philosophy and Practice (e-journal)

This study was conducted to compile a work plan and create an integrated laboratory information system and improve academic services at Uin Sunan Ampel Surabaya based on the implementation of work programs towards a world class university. The purpose of this research activity is to design and implement a system capable of providing work information for each manager of the integration laboratory and maximizing the utilization of the integration laboratory so that the use of the integration laboratory is better and more precise. The results of this research can form an integrated laboratory information system that can optimize the performance …

Estimating The Quality Of Arabian Journals Using Bibliometric Indicators, Isam Mohammed Abdel-Magid, Md. Safiqur Rahaman, Abu Waris, Dr. Mirza Muhammad Naseer, Shakil Ahmad, Manuelraj Peter

Library Philosophy and Practice (e-journal)

Scholarly published scientific journals’ quality and the standard were measured in recent years based on their scientific indicators such as Journal Impact Factor (IF), citation values, and journal ranking values. Any experimental writer and researcher will investigate these factors of journals before publishing their research output. Analyzing and comparing these indicators among different bibliographic databases are welcomed by the research community and will give them some insight to decide or to choose which journals they need to select for publishing their research outputs. The main objective of the research work undertaken was to assess the impact and visibility of 66 …

Breeding And Utilization Of Poa Pratensis L. Cv. Daqingshan, Suying Wen

IGC Proceedings (1977-2023)

No abstract provided.

Conversion Of A Degraded Urban Area To Golf‐School Course In Central Italy, Andrea Pardini, R. Tallarico, D. Parrini

IGC Proceedings (1977-2023)

No abstract provided.

Beef Cattle Performance In A Silvopastoral System Fertilized With N And K, In Brazilian Cerrado, F. S. Bernardino, R. Garcia, J. C. L. Neves, R. G. Tonucci

IGC Proceedings (1977-2023)

No abstract provided.

Electrospray Deposition Of Zno Nanostructures For Nanoscale Electronic Applications, David Hooks

LSU Master's Theses

Modern technology is ever-evolving and as more emphasis is placed on faster, more sensitive electronic devices, advancements in the field of electronics are as important now as they ever have been. To meet the need for more sensitive devices, it is important to study new semiconducting materials and the applications in which they pose a potential advantage.

The field of electronic materials research falls at the intersection of physics, chemistry, materials science, and electrical engineering. Zinc Oxide (ZnO) is of particular interest in modern electronic devices for its uses in sensing applications, high-powered transistors, and LED technology. ZnO has been …

2021-2022 Undergraduate Catalog Language, January 19, 2021, General Education Committee

General Education Committee

No abstract provided.

January 19, 2021, University Of Mississippi. Faculty Senate

Meeting Minutes

Minutes for the January 2021 meeting of the University of Mississippi Faculty Senate.