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2021

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An Examination Of Rapid Force And Emg Rise In The Morning Versus The Evening, Garrett Augsburger, Alisa Soloveva, Christopher Watts, Adam King, Todd Castleberry, Joshua Carr Feb 2021

An Examination Of Rapid Force And Emg Rise In The Morning Versus The Evening, Garrett Augsburger, Alisa Soloveva, Christopher Watts, Adam King, Todd Castleberry, Joshua Carr

International Journal of Exercise Science: Conference Proceedings

Diurnal biological rhythms work on 24-hour periods and are known to influence neuromuscular function. Describing how diurnal rhythms influence maximal neuromuscular function may help optimize training time. PURPOSE: The purpose of the present study was to examine whether the time of day influences the rate of force development (RFD) and the rate of rise (RER) of the surface electromyographic (EMG) signal during maximal isometric contractions of the knee extensors and elbow flexors. METHODS: Twelve healthy, college-aged participants (n = 4 males, n = 8 females) underwent three visits evaluating maximal voluntary contraction (MVC) force of the dominant limb …


The Effectiveness Of Hrv As A Predictor Of Renal Health And Function In The Absence Of Cardiometabolic Diseases. A Pilot Study, Catherine Lowry, Ricardo Torres, Kathleen Adair, Anurag Dhillon, Ahmed Ismaeel, Panagiotis Koutakis, Cassidy Beeson, Jeff S. Forsse Feb 2021

The Effectiveness Of Hrv As A Predictor Of Renal Health And Function In The Absence Of Cardiometabolic Diseases. A Pilot Study, Catherine Lowry, Ricardo Torres, Kathleen Adair, Anurag Dhillon, Ahmed Ismaeel, Panagiotis Koutakis, Cassidy Beeson, Jeff S. Forsse

International Journal of Exercise Science: Conference Proceedings

Heart rate variability (HRV) is a non-invasive way to assess the autonomic nervous system (ANS) influence on the myocardium. The myocardium and cardiovascular system undergo changes throughout the aging process, specifically, renal vascular function. However, in the absence of cardiometabolic diseases, the ANS does not experience the same deleterious changes observed in at-risk populations. What is unknown is if HRV can predict renal health and function (RH/F) in the absence of cardiometabolic diseases. PURPOSE: To determine if HRV is correlated to RH/F in the absence of cardiometabolic diseases. METHODS: Thirteen healthy individuals (n = 7 male; n = 6 female, …


Acylated And Unacylated Ghrelin Impact On Protein Synthesis And Signaling Pathways Of L6 Myotubes, Colleen L. Oreilly, Selina Uranga, James D. Fluckey Feb 2021

Acylated And Unacylated Ghrelin Impact On Protein Synthesis And Signaling Pathways Of L6 Myotubes, Colleen L. Oreilly, Selina Uranga, James D. Fluckey

International Journal of Exercise Science: Conference Proceedings

Ghrelin has recently become a hormone of interest in the fight against type two diabetes. Ghrelin is found in two forms (acylated vs. unacylated), with the acylated form of ghrelin being cited as diabetogenic purportedly due to its interaction with growth hormone secretion. Both the Acylated Ghrelin (AG) and Unacylated Ghrelin (UAG) forms are reported to have metabolic functions within skeletal muscle, despite having little expression of the only known ghrelin receptor known as the growth hormone secretagogue receptor 1a (ghsr-1a). The investigation into AG and UAG on skeletal muscle in type 2 diabetes (T2D) shows promise; however, the measures …


The Influence Of Age And Cardiorespiratory Fitness On Cardiac Autonomic Modulation. A Pilot Study., Ricardo E. Torres, Catherine Lowry, Anurag Dhillon, Kathleen Adair, Ahmed Ismaeel, Panagiotis Koutakis, Jeff S. Forsse Feb 2021

The Influence Of Age And Cardiorespiratory Fitness On Cardiac Autonomic Modulation. A Pilot Study., Ricardo E. Torres, Catherine Lowry, Anurag Dhillon, Kathleen Adair, Ahmed Ismaeel, Panagiotis Koutakis, Jeff S. Forsse

International Journal of Exercise Science: Conference Proceedings

Maximal rate of oxygen consumption (VO2max) is traditionally viewed as the gold standard of determining cardiorespiratory fitness (CF) in healthy and diseased populations. CF has a significant influence on the improvement of cardiac autonomic modulation (CAM) and the risk of morbidity and mortality rates. Heart rate variability (HRV) is a non-invasive way to assess CAM. Age is another factor that influences CAM and CF in healthy and diseased populations. However, what is not fully elucidated, is if CF is maintained at a high level throughout adulthood, will CAM remain relatively unchanged. PURPOSE: To determine if age and CF …


Analyzing The Between-Day Reliability Of Three-Dimensional Body Scanners For Body Composition Assessment, Gabrielle C. Dehaven, Madelin R. Siedler, Matthew T. Stratton, Patrick S. Harty, Christian Rodriguez, Dale Keith, Jacob Green, Jake Boykin, Jacob Dellinger, Sarah White, Abegale D. Williams, Grant M. Tinsley Feb 2021

Analyzing The Between-Day Reliability Of Three-Dimensional Body Scanners For Body Composition Assessment, Gabrielle C. Dehaven, Madelin R. Siedler, Matthew T. Stratton, Patrick S. Harty, Christian Rodriguez, Dale Keith, Jacob Green, Jake Boykin, Jacob Dellinger, Sarah White, Abegale D. Williams, Grant M. Tinsley

International Journal of Exercise Science: Conference Proceedings

In the growing world of health and well-being, three-dimensional (3D) scanning is emerging as a popular tool to assess body composition. While body composition cannot be truly “measured” in living humans, it can be approximated. This, however, leads to two types of errors (i.e., technical and biological) in the body composition assessment. PURPOSE: This study was used to determine what percent or range of percentages in body fat one must exceed before concluding a real change has occurred. By conducting assessments on separate days, with only a short period of time between them, true changes in body composition are …


Techniques For Artificial Hybridization In The Self‐Pollinated Forage Legume Bituminaria Bituminosa And The Cross‐Pollinated Forage Legume Hedysarum Coronarium, D. Real, K. Foster, Enrique Correal, D. Kidd, P. Mendez Feb 2021

Techniques For Artificial Hybridization In The Self‐Pollinated Forage Legume Bituminaria Bituminosa And The Cross‐Pollinated Forage Legume Hedysarum Coronarium, D. Real, K. Foster, Enrique Correal, D. Kidd, P. Mendez

IGC Proceedings (1977-2023)

No abstract provided.


Establishment Of Perennial Forage Crops Using Fast‐Growing Short‐Lived Grasses As Companion Crops, Bruce E. Coulman, Cheryl Duncan, Tim Nelson, Arend Kleinhout Feb 2021

Establishment Of Perennial Forage Crops Using Fast‐Growing Short‐Lived Grasses As Companion Crops, Bruce E. Coulman, Cheryl Duncan, Tim Nelson, Arend Kleinhout

IGC Proceedings (1977-2023)

No abstract provided.


Dual-Crystallizable Silk Fibroin/Poly(L-Lactic Acid) Biocomposite Films: Effect Of Polymer Phases On Protein Structures In Protein-Polymer Blends, Fang Wang, Yingying Li, Christopher R. Gough, Qichun Liu, Xiao Hu Feb 2021

Dual-Crystallizable Silk Fibroin/Poly(L-Lactic Acid) Biocomposite Films: Effect Of Polymer Phases On Protein Structures In Protein-Polymer Blends, Fang Wang, Yingying Li, Christopher R. Gough, Qichun Liu, Xiao Hu

College of Science & Mathematics Departmental Research

Biopolymer composites based on silk fibroin have shown widespread potential due to their brilliant applications in tissue engineering, medicine and bioelectronics. In our present work, biocomposite nanofilms with different special topologies were obtained through blending silk fibroin with crystallizable poly(L-lactic acid) (PLLA) at various mixture rates using a stirring-reflux condensation blending method. The microstructure, phase components, and miscibility of the blended films were studied through thermal analysis in combination with Fourier-transform infrared spectroscopy and Raman analysis. X-ray diffraction and scanning electron microscope were also used for advanced structural analysis. Furthermore, their conformation transition, interaction mechanism, and thermal stability were also …


Dietary Anti-Aging Polyphenols And Potential Mechanisms, Jing Luo, Hongwei Si, Zhenquan Jia, Dongmin Liu Feb 2021

Dietary Anti-Aging Polyphenols And Potential Mechanisms, Jing Luo, Hongwei Si, Zhenquan Jia, Dongmin Liu

Human Sciences Faculty Research

For years, the consumption of a diet rich in fruits and vegetables has been considered healthy, increasing longevity, and decreasing morbidities. With the assistance of basic research investigating the potential mechanisms, it has become clear that the beneficial effects of plant-based foods are mainly due to the large amount of bioactive phenolic compounds contained. Indeed, substantial dietary intervention studies in humans have supported that the supplementation of polyphenols have various health-promoting effects, especially in the elderly population. In vitro examinations on the anti-aging mechanisms of polyphenols have been widely performed, using different types of natural and synthetic phenolic compounds. The …


Long-Term Effects Of Very Low Dose Particle Radiation On Gene Expression In The Heart: Degenerative Disease Risks, Venkata Naga Srikanth Garikipati, Arsen Arakelyan, Eleanor A Blakely, Polly Y Chang, May M Truongcao, Maria Cimini, Vandana Malaredy, Anamika Bajpai, Sankar Addya, Malik Bisserier, Agnieszka Brojakowska, Abrisham Eskandari, Mary K Khlgatian, Lahouaria Hadri, Kenneth M Fish, Raj Kishore, David A Goukassian Feb 2021

Long-Term Effects Of Very Low Dose Particle Radiation On Gene Expression In The Heart: Degenerative Disease Risks, Venkata Naga Srikanth Garikipati, Arsen Arakelyan, Eleanor A Blakely, Polly Y Chang, May M Truongcao, Maria Cimini, Vandana Malaredy, Anamika Bajpai, Sankar Addya, Malik Bisserier, Agnieszka Brojakowska, Abrisham Eskandari, Mary K Khlgatian, Lahouaria Hadri, Kenneth M Fish, Raj Kishore, David A Goukassian

Kimmel Cancer Center Faculty Papers

Compared to low doses of gamma irradiation (γ-IR), high-charge-and-energy (HZE) particle IR may have different biological response thresholds in cardiac tissue at lower doses, and these effects may be IR type and dose dependent. Three- to four-month-old female CB6F1/Hsd mice were exposed once to one of four different doses of the following types of radiation: γ-IR 137Cs (40-160 cGy, 0.662 MeV), 14Si-IR (4-32 cGy, 260 MeV/n), or 22Ti-IR (3-26 cGy, 1 GeV/n). At 16 months post-exposure, animals were sacrificed and hearts were harvested and archived as part of the NASA Space Radiation Tissue Sharing Forum. These heart tissue samples were …


Carbon Fluxes And Microbial Activities From Boreal Peatlands Experiencing Permafrost Thaw, M. P. Waldrop, J. W. Mcfarland, K. L. Manies, M. C. Leewis, S. J. Blazewicz, M. C. Jones, R. B. Neumann, Jason K. Keller, L. Cohen, E. S. Euskirchen, C. Edgar, M. R. Turetsky, W. L. Cable Feb 2021

Carbon Fluxes And Microbial Activities From Boreal Peatlands Experiencing Permafrost Thaw, M. P. Waldrop, J. W. Mcfarland, K. L. Manies, M. C. Leewis, S. J. Blazewicz, M. C. Jones, R. B. Neumann, Jason K. Keller, L. Cohen, E. S. Euskirchen, C. Edgar, M. R. Turetsky, W. L. Cable

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Permafrost thaw in northern ecosystems may cause large quantities of carbon (C) to move from soil to atmospheric pools. Because soil microbial communities play a critical role in regulating C fluxes from soils, we examined microbial activity and greenhouse gas production soon after permafrost thaw and ground collapse (into collapse‐scar bogs), relative to the permafrost plateau or older thaw features. Using multiple field and laboratory‐based assays at a field site in interior Alaska, we show that the youngest collapse‐scar bog had the highest CH4 production potential from soil incubations, and, based upon temporal changes in porewater concentrations and 13 …


Full Issue For Tgle Vol. 53 Nos. 3 & 4 Feb 2021

Full Issue For Tgle Vol. 53 Nos. 3 & 4

The Great Lakes Entomologist

Full issue for TGLE Vol. 53 Nos. 3 & 4


Florida's Harmful Algal Blooms: Tiny Organisms Needing Massive Legislation, Jillian Barnard Feb 2021

Florida's Harmful Algal Blooms: Tiny Organisms Needing Massive Legislation, Jillian Barnard

Environmental and Earth Law Journal (EELJ)

No abstract provided.


The Forage Selection Program At The Cerrados Research Center--33 Years Of Contributions For The Tropics, Marcelo A. Carvalho, Claudio T. Karia, A. O. Barcellos, G. G. Leite, Lourival Vilela, Allan K. B. Ramos, Francisco Duarte Fernandes, S. V. Paula-Moraes, G. B. Martha Júnior, R. Guimarães Júnior Feb 2021

The Forage Selection Program At The Cerrados Research Center--33 Years Of Contributions For The Tropics, Marcelo A. Carvalho, Claudio T. Karia, A. O. Barcellos, G. G. Leite, Lourival Vilela, Allan K. B. Ramos, Francisco Duarte Fernandes, S. V. Paula-Moraes, G. B. Martha Júnior, R. Guimarães Júnior

IGC Proceedings (1977-2023)

No abstract provided.


Total Salivary Protein Concentration And Its Correlation To Dental Caries, Emyli Peralta, Jonathan Joseph Feb 2021

Total Salivary Protein Concentration And Its Correlation To Dental Caries, Emyli Peralta, Jonathan Joseph

The Pegasus Review: UCF Undergraduate Research Journal

According to the World Health Organization, dental cavities are the number one chronic disease in children. Saliva coats the teeth all day and serves many functions to maintain and protect teeth. Saliva has many proteins that can be both detrimental and essential to the preservation of tooth enamel. The purpose of this study was to determine if a correlation exists between the total protein concentration in saliva and the prevalence of cavities in the mouth. We hypothesized that there would be a positive correlation between total salivary protein concentration and the prevalence of cavities in the participant.Saliva samples were collected …


Determination Of The Rydberg Constant From The Emission Spectra Of H And He+, Kyle D. Shaffer Feb 2021

Determination Of The Rydberg Constant From The Emission Spectra Of H And He+, Kyle D. Shaffer

Ramifications

Abstract

In this experiment, the Rydberg constants for the hydrogen atom and He+ were determined by analysis of the emission spectra of Hand He, respectively, in comparison to the principal quantum numbers of each transition. Using both a hydrogen and then a helium atomic lamp attached to a 0.5 m grating spectrometer and a photomultiplier detector (PMT), a change in voltage detected by the PMT can be paired with a corresponding wavelength passing through the spectrometer from each emission peak in the visible to ultraviolet range. The peaks acquired from this change in voltage were analyzed to find their …


The Human Instinct To Resilience: Clinical And Evolutionary Efficacy Of Intrinsically Motivated Stressor Exposure, Brady Barley Feb 2021

The Human Instinct To Resilience: Clinical And Evolutionary Efficacy Of Intrinsically Motivated Stressor Exposure, Brady Barley

Ramifications

Environmental stressors threaten optimal behavioral functioning, and thus contribute to the development of psychopathology and exert evolutionary selection pressure. Voluntary stressor exposure has the efficacious effect of increasing resilience to future stressors in humans and other animals. This theoretical paper considers the hypothesis that intrinsic motivation toward behaviors requiring voluntary stressor exposure mitigates evolutionary selection pressure exerted by environmental stressors by inducing neural and neuroendocrine plasticity which results in increased resilience. In this view, intrinsically motivated stressor exposure is both efficacious and innate. Empirical and theoretical support for this hypothesis suggest that humans possess an instinct to resilience. Stress-related disorders …


Is There A “Mulatto Escape Hatch” Out Of Racism?: A Reflection On Multiracial Exceptionalsim During A Time Of #Blacklivesmatter, Tanya Katerí Hernández Feb 2021

Is There A “Mulatto Escape Hatch” Out Of Racism?: A Reflection On Multiracial Exceptionalsim During A Time Of #Blacklivesmatter, Tanya Katerí Hernández

Journal of Civil Rights and Economic Development

(Excerpt)

To have a symposium organized to review the ideas in my book, Multiracials and Civil Rights: Mixed-Race Stories of Discrimination, is an honor, and the JCRED editors, along with their dynamic Faculty Advisors Elaine Chiu and Rosa Castello, have my gratitude for pulling it all together. Having each symposium contributor take the time to deeply engage the ideas in the book is an incredible gift, and exactly what every author dreams of—being read and provoking reflection. Without readers, ideas do not have an opportunity to matter. Thank you Taunya Lovell Banks, Nancy Chi Cantalupo, and Jasmine Mitchell, for …


“I Think You Didn't Get It Because They Misidentified You As Latina”: A Commentary On Multiracials And Civil Rights: Mixed-Race Stories Of Discrimination, Nancy Chi Cantalupo Feb 2021

“I Think You Didn't Get It Because They Misidentified You As Latina”: A Commentary On Multiracials And Civil Rights: Mixed-Race Stories Of Discrimination, Nancy Chi Cantalupo

Journal of Civil Rights and Economic Development

(Excerpt)

Liz was interviewing for a tenure-track, entry-level law faculty position at Law School X, “ranked” (in that year) around 100. She had heard a rumor that the law school was determined to hire a person who would add to the diversity of the faculty, which was both White- and male-dominated.

Liz’s “job talk,” a presentation on a current article that she was writing, used Liz’s own multiracial identification to illustrate a point relevant to her research, which utilized both critical race theory and feminist legal theory. In the course of explaining her illustration, Liz mentioned that she was often …


Personal Identity Equality And Racial Misrecognition: Review Essay Of Multiracials And Civil Rights: Mixed-Race Stories Of Discrimination, Taunya Lovell Banks Feb 2021

Personal Identity Equality And Racial Misrecognition: Review Essay Of Multiracials And Civil Rights: Mixed-Race Stories Of Discrimination, Taunya Lovell Banks

Journal of Civil Rights and Economic Development

(Excerpt)

There is a growing body of social science literature documenting multiracials as an “emergent minority group. . . who . . . have not always been recognized as either a separate racial group or as legitimate members of racial groups.” Tanya Hernández has been writing about aspects of American multiracialism for twenty years. Her 1998 article in the MARYLAND LAW JOURNAL focused on the multiracial discourse about racial categories on the 2000 U.S. census. In that article, she analyzes the multiracial identity movement’s effort to get a multiracial category on the U.S. census. Although that movement failed, the 2000 …


Commentary And Book Review: Multiracials And Civil Rights: Mixed-Race Stories Of Discrimination, Jasmine Mitchell Feb 2021

Commentary And Book Review: Multiracials And Civil Rights: Mixed-Race Stories Of Discrimination, Jasmine Mitchell

Journal of Civil Rights and Economic Development

(Excerpt)

Can a drop of whiteness or “looking white” save someone from anti-Blackness? Are mixed-race peoples special, and should they be a protected class under the law? Did Loving v. Virginia’s legalization of interracial marriage lead to race becoming insignificant? Tanya Hernández’s Multiracials and Civil Rights: Mixed-Race Stories of Discrimination debunks persistent myths that racial mixture will eradicate racism and heal the racial wounds of the United States. Using cases and other legal sources, Hernández persuasively argues that multiracials are not exempt from racial discrimination. Multiracials and Civil Rights crystalizes the pervasiveness of white supremacy while offering a sociopolitical lens …


Scientometric Visualisation Of Fifteen Years Of Indian Engineering Research Output, Shambhu Jaali, Vitthal T. Bagalkoti, Chaman Sab M, Mallikarjun Kappi Feb 2021

Scientometric Visualisation Of Fifteen Years Of Indian Engineering Research Output, Shambhu Jaali, Vitthal T. Bagalkoti, Chaman Sab M, Mallikarjun Kappi

Library Philosophy and Practice (e-journal)

Engineering is the most preferred research area among Indian research and development for quite some time in terms of the total number of publications, global share, and visibility and citation impact are concerned. The present study deals with the assessment of Indian engineering research output as reflected in the Web of Science (WOS) database for the period 2003 to 2017 for identifying the research output in the field of engineering literature. We measure India’s contribution to engineering research from a global perspective. In the fifteen years, 2003-2017 Indian researchers have published 1,589,361 papers in 1,266 journals. In terms of % …


Network Visualization Of A Retracted Article: Repeated Proliferation Of Error Through Citation Networks, Rosy Jan, Kirat Nazir, Kushboo Rani, Irtiza Peer, Waseem Farooq Feb 2021

Network Visualization Of A Retracted Article: Repeated Proliferation Of Error Through Citation Networks, Rosy Jan, Kirat Nazir, Kushboo Rani, Irtiza Peer, Waseem Farooq

Library Philosophy and Practice (e-journal)

Retraction is used as an optimum tool to uphold and safe-guide the integrity of scholarly literature. However, knowingly or unknowingly the authors build the work on these false claims by citing the retracted articles. Such dependencies on retracted articles may become implicit and indirect causing profound and long-lasting threat to the credibility of the literature. Consequently, it is important to detect and analyze such threats. The article aims to demonstrate dependency of citing articles on retracted article with reference to the rest of the literature. A case study of highly cited (as reported by retraction watch) retracted article ”Spontaneous …


Medical School Watercooler Newsletter - February 12, 2021, Lindsey Lyle Feb 2021

Medical School Watercooler Newsletter - February 12, 2021, Lindsey Lyle

Watercooler Newsletter

This is the February 12, 2021 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

  • Virtual conference to focus on innovations in learning
  • Meet a Med Student: Sydney Brown
  • Match Day 2021 to be held in person
  • Pathologist calls on scientific community to standardize naming of gene products
  • New report addresses challenges and needs of minority communities amid the COVID-19 crisis


Anthropogenic And Climatic Factors Interact To Influence Reproductive Timing And Effort, Susannah S. French, Geoffrey Smith Feb 2021

Anthropogenic And Climatic Factors Interact To Influence Reproductive Timing And Effort, Susannah S. French, Geoffrey Smith

Browse all Datasets

Reproduction, although absolutely essential to a species’ persistence, is in itself challenging. As anthropogenic change increasingly affects every landscape on Earth, it is critical to understand how specific pressures impact the reproductive efforts of individuals, which directly contribute to the success or failure of populations. However, organisms rarely encounter a single burden at a time, and the interactions of environmental challenges can have compounding effects. Disentangling environmental and physiological pressures is difficult because they are often context-dependent and not generalizable, but long-term monitoring across variable landscapes and weather patterns can improve our understanding of these complex interactions. We tested the …


Why Did You Become A Police Officer? Entry-Related Motives And Concerns Of Women And Men In Policing, Samantha S. Clinkinbeard, Starr Solomon, Rachael Rief Feb 2021

Why Did You Become A Police Officer? Entry-Related Motives And Concerns Of Women And Men In Policing, Samantha S. Clinkinbeard, Starr Solomon, Rachael Rief

Criminology and Criminal Justice Faculty Publications

As police agencies in the United States suffer declining applications and struggle to recruit women, the National Institute of Justice has identified workforce development as a priority research area. To recruit more effectively, we must understand what attracts people to policing and what deters them. We surveyed officers in two Midwestern police departments (n = 832) about entry motivations and concerns and examined gender differences. Serve/protect motivations were most important for men and women, though women rated the category significantly higher. Women and non-White officers rated legacy motives higher than did males and White officers. Women reported more concerns …


Could Changes To The Endangered Species Act Actually Threaten Species?, Manuel L. Colon Jr. Feb 2021

Could Changes To The Endangered Species Act Actually Threaten Species?, Manuel L. Colon Jr.

Villanova Environmental Law Journal (1991 - )

No abstract provided.


Gardner-Webb Alumnus Uses Writing And Entrepreneurial Skills To Start Business, Office Of University Communications Feb 2021

Gardner-Webb Alumnus Uses Writing And Entrepreneurial Skills To Start Business, Office Of University Communications

Gardner-Webb NewsCenter Archive

In celebration of Black History Month during February, Gardner-Webb University will introduce you to alumni who are making a difference in the world around them. Through their jobs and creative passions, these alumni are inspiring others to achieve their dreams.

Since earning his undergraduate and graduate degrees from Gardner-Webb University, Harrison Martin, of Pfafftown, N.C., has started a business doing what he loves—reviewing movies and writing. The entrepreneur is a member of two film critics organizations and recently published a children’s book, “The Bacon Tree.” His second book, “B is for Bacon Tree: Bacon from A to Z,” will be …


A Matter Of Life Or Death: Productively Infected And Bystander Cd4 T Cells In Early Hiv Infection, Dechao Cao, Sushant Khanal, Ling Wang, Zhengke Li, Juan Zhao, Lam N. Nguyen, Lam N. Nguyen, Xindi Dang, Madison Schank, Bal K. C. Thakuri, Jinyu Zhang, Zeyuan Lu, Xiao Y. Wu, Zheng D. Morrison, Mohamed El Gazzar, Shunbin Ning, Jonathan P. Moorman, Zhi Q. Yao Feb 2021

A Matter Of Life Or Death: Productively Infected And Bystander Cd4 T Cells In Early Hiv Infection, Dechao Cao, Sushant Khanal, Ling Wang, Zhengke Li, Juan Zhao, Lam N. Nguyen, Lam N. Nguyen, Xindi Dang, Madison Schank, Bal K. C. Thakuri, Jinyu Zhang, Zeyuan Lu, Xiao Y. Wu, Zheng D. Morrison, Mohamed El Gazzar, Shunbin Ning, Jonathan P. Moorman, Zhi Q. Yao

ETSU Faculty Works

CD4 T cell death or survival following initial HIV infection is crucial for the development of viral reservoirs and latent infection, making its evaluation critical in devising strategies for HIV cure. Here we infected primary CD4 T cells with a wild-type HIV-1 and investigated the death and survival mechanisms in productively infected and bystander cells during early HIV infection. We found that HIV-infected cells exhibited increased programmed cell death, such as apoptosis, pyroptosis, and ferroptosis, than uninfected cells. However, productively infected (p24+) cells and bystander (p24-) cells displayed different patterns of cell death due to differential expression of pro-/anti-apoptotic proteins …


Volume Cxxxix, Number 13, February 12, 2021, Lawrence University Feb 2021

Volume Cxxxix, Number 13, February 12, 2021, Lawrence University

The Lawrentian

No abstract provided.