Digital Commons Network^™

Reg4 And Its Downstream Transcriptional Activator Cd44icd In Stage Ii And Iii Colorectal Cancer, Jared A. Sninsky, Kumar S. Bishnupuri, Iván González, Nikolaos A. Trikalinos, Ling Chen, Brian K. Dieckgraefe

Open Access Publications

Reg4 is highly expressed in gastrointestinal malignancies and acts as a mitogenic and pro-invasive factor. Our recent works suggest that Reg4 binds with CD44 and induces its proteolytic cleavage to release intra-cytoplasmic domain of CD44 (CD44ICD). The goal of this study is to demonstrate clinical significance of the Reg4-CD44/CD44ICD pathway in stage II/III colon cancer and its association with clinical parameters of aggression. We constructed a tissue microarray (TMA) of 93 stage II/III matched colon adenocarcinoma patients, 23 with recurrent disease. The TMA was immunohistochemically stained for Reg4, CD44, and CD44ICD proteins and analyzed to identify associations with tumor characteristics, …

Usage Of Researchgate By The Research Scholars: A Study Of The University Of Calcutta, Debdas Mondal, Debal Chandra Kar Phd

Library Philosophy and Practice (e-journal)

Academic social network sites (ASNS) have emerge as an opportunity to facilitate outreach of research work, share research data, ideas, collaboration, and knowledge. The present study is an attempt to report the use of ResearchGate, one of the academic social networking sites by the Research Scholars of the University of Calcutta. The study has used the two most common methods of survey, namely the descriptive survey method and the questionnaire tool. A sample of 140 researchers from Calcutta University was invited to participate in the survey. An online questionnaire was prepared over Google forms platform and spread. It was found …

Genetic Analysis Of Selfed And Open Pollinated Progenies Of Stylosanthes Capitata, Rosangela M. S. Resende, M. D. V. Resende, Liana Jank, Lucimara Chiari, Cacilda B. Valle

IGC Proceedings (1977-2023)

No abstract provided.

Establishment And Growth Of Tall Fescue (Festuca Arundinacea) Cultivars With Spring Sowing In Southern Australia, Zhongnan Nie, B. Clark

IGC Proceedings (1977-2023)

No abstract provided.

Playing With Sharks, Jodi Mcdavid

Journal of Religion & Film

This is a film review of Playing With Sharks (2021), directed by Sally Aitken.

Pre-Service Teachers As Curriculum Makers: What Could Social Justice Look Like In A Middle School Curriculum?, Brittany A. Aronson, Emily Culberson, Britt Hochstetler, Suzanne Lowman, Ash Mccartney, Jocelyn Mcminimy, Emily Murphy, Ralph Newlin, Emily Santen, Rachel Sutphin, Megan Terlau, Nicholas Vrzal, Imani Wheeler

Journal of Educational Research and Innovation

In this article, we answer the questions 1) What could social justice look like in the middle school curriculum; 2) How do we help young adolescents recognize and repudiate racism and other forms of social injustice; and 3) What are some lessons learned from a middle level teacher preparation with a focus on social justice ? By presenting three examples of social justice curriculum created by pre-service teachers in their teacher leadership education course, we argue for spaces that allow pre-service teachers to be curriculum-makers if we are truly seeking social justice educators in schools. We conclude, through the perspective …

Construction, Characterization And Crystal Structure Of A Fluorescent Single-Chain Fv Chimera, Nileena Velappan, Devin Close, Li Wei Hung, Leslie Naranjo, Colin Hemez, Natasha Devore, Donna K. Mccullough, Antonietta M. Lillo, Geoffrey S. Waldo, Andrew R. M. Bradbury

College of Natural and Applied Sciences

In vitro display technologies based on phage and yeast have a successful history of selecting single-chain variable fragment (scFv) antibodies against various targets. However, single-chain antibodies are often unstable and poorly expressed in Escherichia coli. Here, we explore the feasibility of converting scFv antibodies to an intrinsically fluorescent format by inserting the monomeric, stable fluorescent protein named thermal green, between the light- and heavy-chain variable regions. Our results show that the scTGP format maintains the affinity and specificity of the antibodies, improves expression levels, allows one-step fluorescent assay for detection of binding and is a suitable reagent for epitope binning. …

Faculty Handbook Section Iii - College Of Liberal Arts Policies And Procedures - Updated 2/15/2021, All Faculty

Faculty Handbooks

No abstract provided.

University Of Dayton Honors Six Undergraduate Students For Research In Catholic Intellectual Traditions, Dave Larsen

College of Arts and Sciences Newsroom

Six University of Dayton students will be honored this month as the first recipients of the Fr. Jack McGrath, S.M., Award for Research in Catholic Intellectual Traditions, which recognizes outstanding undergraduate student research in a Common Academic Program course related to Catholic intellectual traditions.

Gwu College Of Education Waives Gre Or Mat Scores For National Board Certified Teachers, Office Of University Communications

Gardner-Webb NewsCenter Archive

Educators who have completed National Board Certification are leaders in their field. In recognition of this achievement, Gardner-Webb University College of Education will waive GRE or MAT scores for National Board Certified Teachers (NBCTs) applying to GWU’s Doctor of Education programs in Educational Leadership (EDLS) and Curriculum and Instruction (EDCI).

Aberrant Azin2 And Polyamine Metabolism Precipitates Tau Neuropathology, Leslie A. Sandusky-Beltran, Andrii Kovalenko, Devon S. Placides, Kevin Ratnasamy, Chao Ma, Jerry B. Hunt, Huimin Liang, John Ivan T. Calahatian, Camilla Michalski, Margaret Fahnestock, Laura J. Blair, April L. Darling, Jeremy D. Baker, Sarah N. Fontaine, Chad A. Dickey, Joshua J. Gamsby, Kevin R. Nash, Erin L. Abner, Maj-Linda B. Selenica, Daniel C. Lee

Sanders-Brown Center on Aging Faculty Publications

Tauopathies display a spectrum of phenotypes from cognitive to affective behavioral impairments; however, mechanisms promoting tau pathology and how tau elicits behavioral impairment remain unclear. We report a unique interaction between polyamine metabolism, behavioral impairment, and tau fate. Polyamines are ubiquitous aliphatic molecules that support neuronal function, axonal integrity, and cognitive processing. Transient increases in polyamine metabolism hallmark the cell’s response to various insults, known as the polyamine stress response (PSR). Dysregulation of gene transcripts associated with polyamine metabolism in Alzheimer’s disease (AD) brains were observed, and we found that ornithine decarboxylase antizyme inhibitor 2 (AZIN2) increased to …

A New Agent-Based Model Provides Insight Into Assumptions In Modeling Forest Management Under Deep Uncertainty, Garry Sotnik, Robert M. Scheller, Brooke Alyce Cassell, Matthew Joshua Duveneck

Environmental Science and Management Faculty Publications and Presentations

Context: Exploratory modeling in forestry uses a variety of approaches to study forest management questions. One key assumption that every approach makes is about the degree of deep uncertainty—the lack of knowledge required for making an informed decision—that future forest managers will face. This assumption can strongly influence simulation results and the conclusions drawn from them, but is rarely studied.

Objectives: Our objective was to measure the degree of deep uncertainty within a forest management simulation to compare alternative modeling approaches and improve understanding of when a specific approach should be applied. Methods We first developed a method for measuring …

Reproducing Race In An Era Of Reckoning, Dov Fox

Minnesota Law Review Headnotes, Vols. 94-106 (2009-2022)

What place should racial preferences have when people make a family? People might have all sorts of reasons for caring about race in their search for a romantic partner, sperm or egg donor, or child to foster or adopt. Maybe they think such resemblance will make it easier for them to bond with their kids, or easier for others to appreciate they are the parents. A growing school of legal scholars condemns racial matching in the buying and selling of reproductive materials specifically—on the ground that it shores up racial hierarchy and promotes eugenic logic. I see two problems with …

Generation Of A Biobank From Two Adult Thoroughbred Stallions For The Functional Annotation Of Animal Genomes Initiative, Callum G. Donnelly, Rebecca R. Bellone, Erin N. Hales, Annee Nguyen, Scott A. Katzman, Ghislaine A. Dujovne, Kelly E. Knickelbein, Felipe Avila, Ted S. Kalbfleisch, Elena Giulotto, Nicole B. Kingsley, Jocelyn Tanaka, Elizabeth Esdaile, Sichong Peng, Anna Dahlgren, Anna Fuller, Michael J. Mienaltowski, Terje Raudsepp, Verena K. Affolter, Jessica L. Petersen, Carrie J. Finno

Department of Animal Science: Faculty Publications

Following the successful creation of a biobank from two adult Thoroughbred mares, this study aimed to recapitulate sample collection in two adult Thoroughbred stallions as part of the Functional Annotation of the Animal Genome (FAANG) initiative. Both stallions underwent thorough physical, lameness, neurologic, and ophthalmic (including electroretinography) examinations prior to humane euthanasia. Epididymal sperm was recovered from both stallions immediately postmortem and cryopreserved. Aseptically collected full thickness skin biopsies were used to isolate, culture and cryopreserve dermal fibroblasts. Serum, plasma, cerebrospinal fluid, urine, and gastrointestinal content from various locations were collected and cryopreserved. Under guidance of a board-certified veterinary anatomic …

Physical Mapping Of The Anopheles (Nyssorhynchus) Darlingi Genomic Scaffolds, Míriam Silva Rafael, Leticia Cegatti Bridi, Igor V. Sharakhov, Osvaldo Marinotti, Maria V. Sharakhova, Vladimir A. Timoshevskiy, Giselle Moura Guimarães-Marques, Valéria Silva Santos, Carlos Gustavo Nunes Da Silva, Spartaco Astolfi-Filho, Wanderli Pedro Tadei

Biology Faculty Publications

The genome assembly of Anopheles darlingi consists of 2221 scaffolds (N50 = 115,072 bp) and has a size spanning 136.94 Mbp. This assembly represents one of the smallest genomes among Anopheles species. Anopheles darlingi genomic DNA fragments of ~37 Kb were cloned, end-sequenced, and used as probes for fluorescence in situ hybridization (FISH) with salivary gland polytene chromosomes. In total, we mapped nine DNA probes to scaffolds and autosomal arms. Comparative analysis of the An. darlingi scaffolds with homologous sequences of the Anopheles albimanus and Anopheles gambiae genomes identified chromosomal rearrangements among these species. Our results confirmed that physical mapping …

The Influence Of Geographic Variation In Vegetation Characteristics On Habitat Use And Productivity Of An Endangered Warbler, Ashley M. Long, Heather A. Mathewson, Michael L. Morrison

Faculty Publications

Understanding how geographic variation in environmental conditions influences species’ distributions and population dynamics is critical for effective management of at-risk species and can help us anticipate wildlife responses to future change. The Golden-cheeked Warbler (Setophaga chrysoparia; hereafter warbler) is an endangered migratory songbird that nests in oak-juniper woodland in Texas. From 2009 to 2013, we monitored 895 warbler territories at 90 study sites located across the warbler's breeding range to examine how geographic variation in vegetation characteristics influenced aspects of warbler habitat selection and productivity. We found range-wide variation in the tree species composition and vegetation structure of warbler habitat. …

European Aspen With High Compared To Low Constitutive Tannin Defenses Grow Taller In Response To Anthropogenic Nitrogen Enrichment, Franziska Bandau, Benedicte Riber Albrectsen, Kathryn M. Robinson, Michael J. Gundale

Aspen Bibliography

Boreal forests receive nitrogen-(N)-enrichment via atmospheric deposition and industrial fertilization. While it is known that N-enrichment can intensify interactions with natural antagonists, it remains poorly understood how genetic variability in plant defense chemistry can affect biotic interactions and height growth in N-enriched environments. We grew replicates of five low- and high-tannin Populus tremula genotypes, respectively, under three N-treatments (ambient, 15, and 150 kg N ha−1 yr−1). We assessed shoot blight occurrence (i.e. symptoms caused by Venturia fungi) during four growing seasons, and tree height growth during the same period. Damage by Venturia spp. increased with N-addition during all years, likely …

Crow's Nest, February 15, 2021, Crow's Nest Staff

Crow's Nest

The February 15, 2021, issue of the Crow's Nest.

Genetic Variants And Physical Activity Interact To Affect Bone Density In Hispanic Children, Ruixue Hou, Shelley A Cole, Mariaelisa Graff, Yujie Wang, Karin Haack, Sandra Laston, Nitesh R Mehta, Roman J Shypailo, Margaret L Gourlay, Anthony G Comuzzie, Kari E North, Nancy F Butte, Venkata Saroja Voruganti

Children’s Nutrition Research Center Staff Publications

Background: Our aim was to investigate if moderate to vigorous physical activity (MVPA), calcium intake interacts with bone mineral density (BMD)-related single nucleotide polymorphisms (SNPs) to influence BMD in 750 Hispanic children (4-19y) of the cross-sectional Viva La Familia Study.

Methods: Physical activity and dietary intake were measured by accelerometers and multiple-pass 24 h dietary recalls, respectively. Total body and lumbar spine BMD were measured by dual energy X-ray absorptiometry. A polygenic risk score (PRS) was computed based on SNPs identified in published literature. Regression analysis was conducted with PRSs, MVPA and calcium intake with total body and lumbar spine …

Formation Of Gas Jets And Vortex Rings From Bursting Bubbles: Visualization, Kinematics, And Fluid Dynamics, Ali A. Dasouqi

USF Tampa Graduate Theses and Dissertations

The bursting of bubbles at an air-liquid interface is an important physical process in many environmental and industrial applications. Bubble bursting has implications for climate (e.g. marine aerosol formation; Veron 2015), human respiratory health (e.g. aerosolization of harmful substances; Prather et al 2013), food science (e.g. beer and champagne bubbles; Liger-Belair et al 2009), industry (e.g. processes such as gas fluxing and electrowinning; Zhang et al 2011), and volcanology (e.g. Strombolian eruptions; Chojnicki et al 2015). Much of the previous research into bubble bursting has focused on the fluid dynamics of the liquid component, namely the bubble cap film rupture …

Metaphoric Recursiveness And Ternary Ontology: Another Look At The Language And Worldview Of The Yaminahua, Carlos A. Segovia

Tipití: Journal of the Society for the Anthropology of Lowland South America

My purpose in this paper is, first, to explore metaphorical recursiveness in Yaminahua, i.e. the latter’s folding of the common binary structure: {(x) things + (y) words} into the threefold scheme: (A) things + (B) external analogies + (C) internal metaphors, as displaying a multi-iconic semiotic system of the type: A ≈ [B] ≈ C, which is finally reduced to a twofold indexical system: A ← [B], contra Graham Townsley’s dismissal of semiotic theory as being of no relevance in contrast to cognitive construction. And, secondly, to show that within the traditional Yaminahua worldview "animism," "totemism," …

Dietary Quality And Dietary Inflammatory Potential During Pregnancy And Offspring Emotional And Behavioral Symptoms In Childhood: An Individual Participant Data Meta-Analysis Of Four European Cohorts, Kinga Polanska, Pawel Kaluzny, Adrien M. Aubert, Liesbeth Duijts, Hanan El Marroun, Wojciech Hanke, James R. Hébert, Barbara Heude, Agnieszka Jankowska, Giulia Mancano, Sara M. Mensink-Bout, Caroline Relton, Nitin Shivappa Mbbs, Mph, Ph.D., Matthew Suderman, Elzbieta Trafalska, Ewelina Wesolowska, Raquel Garcia-Esteban, Mònica Guxens, Maribel Casas, Catherine M. Phillips

Faculty Publications

Background

The impact of maternal diet during pregnancy on child neurodevelopment is of public health and clinical relevance. We evaluated the associations of dietary quality based on the Dietary Approaches to Stop Hypertension (DASH) score and dietary inflammatory potential based on the energy-adjusted Dietary Inflammatory Index (E-DII) score during pregnancy with emotional and behavioral symptoms of offspring at 7 to 10 years of age.

Methods

Individual participant data for 11,870 mother–child pairs from four European cohorts participating in the ALPHABET project were analyzed. Maternal antenatal DASH and E-DII scores were generated from self-completed food frequency questionnaires. Symptoms of depression …

February 15, 2021, Saint Mary's College Of California

The Collegian

No abstract provided.

Potential Of Fungi Isolated From Diesel Contaminated Soil To Degrade Diesel, Oluwafemi Oyewole, Ramat Raji, Suzan Okeke, Gift Chukwuma, Japhet Yakubu

Tanzania Journal of Science

Diesel is a complex mixture and a common pollutant, consisting mainly of aliphatic hydrocarbons ranging from C9 to C23 and a number of aromatic compounds. The main purpose of this study was to isolate fungi from diesel contaminated soil for biodegradation of diesel contaminated soil. Two fungal species (Aspergillus flavus and Saccharomyces cerevisiae) were isolated from a diesel contaminated site using cultural and biochemical characterisation. The isolates were screened for their ability to utilize diesel as carbon source. The biodegradation rate of the fungi isolated was measured by determining the optical density using spectrophotometry. The fungal isolates were further tested …

Isolation And Quantification Of Flavonoids From Kigelia Africana (Lam.) Benth Fruit And Bark And Their Antiradical And Antibacterial Activities, Pamhidzai Dzomba, George Mhini

Tanzania Journal of Science

Kigelia africana is an evergreen deciduous tree used in Zimbabwe folklore medicine for wound and diabetes ulcers healing. This paper reports the isolation and quantification of flavonoids from stem barks and fruits of K. africana as well as their antibacterial and antiradical activities. Flavonoids in ethanol and ethyl-acetate extracts were quantified using UV-Vis spectrophotometry and were found to be 213.490 ± 0.001 mg/L and 36.614 ± 0.001 mg/L, respectively per quercetin equivalent. The preparative and analytical thin layer chromatography was used to profile the flavonoids from fruits and barks using ethyl-acetate and petroleum ether (3:7 v/v) mobile solvent systems. Ethanol …

Antibacterial Activities Of Hyphaene Thebaica (Doum Palm) Fruit Extracts Against Intestinal Microflora And Potential Constipation Associated Pathogens In Yola Metropolis, Nigeria, Joel Ewansiha, Chidimma Ugo, Damaris Kolawole, Lilian Orji

Tanzania Journal of Science

This study aimed at determining the antibacterial activities of Hyphaene thebaica fruit extracts against some intestinal constipation associated bacteria. Qualitative analysis of some phytochemical constituents, agar well diffusion and broth dilution methods were used to determine the zones of inhibition and minimum inhibitory concentration (MIC) of the plant extracts. Phytochemical components viz flavonoids, saponins, terpenoids, tannins, phenols, alkaloids, glycosides and steroids were detected in the plant extracts, and the test organisms were susceptible to the plant extracts. The diameter zone of inhibition (DZI) obtained with n-hexane extract ranged from 15.10 ± 0.51 mm to 2.0 ± 0.55 mm against K. …

Forest Structure And Climate Change Mitigation Potential: A Case Of Wilolesi And Ikonongo Forested Hills In Iringa Municipality, Tanzania, Evarist Fundisha, Hamidu Seki, Anasia Saria

Tanzania Journal of Science

Vegetation plays major roles in carbon storage and ecosystem functioning by modifying the rate of carbon fluxes thereby mitigating climate change. However, the focus of assessing the potentials for different vegetation on climate change mitigation has for so long been conducted outside cities, towns and municipalities. This study was conducted in Wilolesi and Ikonongo hills located in Iringa as representative of the Municipality forested hills in Tanzania to assess vegetation structure and their potential for climate change mitigation. Random sampling technique was employed to establish 20 rectangular plots of 20 m x 40 m (0.08 ha) in each hill to …

Hiv/Aids Transmission Dynamics: Modelling The Roles Of Long Distance Truck Drivers, Nyimvua Mbare

Tanzania Journal of Science

A mathematical model to investigate the roles of long distance truck drivers on HIV transmission dynamics was formulated and analyzed to establish the existence of disease free and endemic equilibrium points. The results show that, the disease free equilibrium point is asymptotically stable when the basic reproduction number is less than unity and unstable otherwise. Furthermore, comprehensive analyses on the two steady states (infection free and endemic) have shown that they are both globally and asymptotically stable. Sensitivity analysis is performed on the reproduction number in order to establish the relative importance of parameters, and it shows that the truck …

Effects Of Drying, Packaging Conditions And Storage Time On Proximate Composition Of Chia Seeds (Salvia Hispanica), Ashura Katunzi-Kilewela, Leonard Rweyemamu, Oscar Kibazohi, Lilian Kaale

Tanzania Journal of Science

The effects of drying, packaging conditions and storage time on proximate composition of chia seeds were investigated. Chia seeds were dried at 63 °C for 30 min (low-temperature long time–LTLT) and at 75 °C for 30 s (high-temperature short time-HTST) using dry oven, air/vacuum-packed and stored for ten weeks. The effect of heat processing (drying) on chia seeds had significant difference (p < 0.05) in ash, fiber and fat contents while there was no significant difference (p > 0.05) in moisture and protein contents. Except for fiber content, there was no significant difference (p > 0.05) in moisture, ash, fat and protein of chia seeds dried at LTLT and HTST before storage. During storage time, there was …

Effects Of Plant Species Diversity And Biomass On Grazing Patch Selection By Semi Free-Ranging Cattle, Samora Andrew

Tanzania Journal of Science

Studies examining forage selection by large herbivores have generally focused on single herbivore-plant relationships and few studies link plant species diversity with large herbivore feeding preferences, particularly in species-rich ecosystems. A study was therefore conducted to examine how herbaceous plant biomass, species richness, diversity and evenness, together with elevation and distances to houses, agricultural fields and cattle holding-pen areas (kraals), predict cattle grazing intensity at small (0.5 x 0.5 m) and large (20 x 50 m) patches by semi free-ranging indigenous cattle in Kilombero Valley Floodplain wetland Tanzania. Results showed that cattle grazed patches with high species richness and intermediate …