Digital Commons Network^™

Thinking Big And Thinking Small: A Conceptual Framework For Best Practices In Community And Stakeholder Engagement In Food, Energy, And Water Systems, Andrew Kliskey, Paula Williams, David L. Griffith, Virginia H. Dale, Chelsea Schelly, Anna Maria Marshall, Valoree Gagnon, Weston M. Eaton, Kristin Floress

Michigan Tech Publications, Part 1

Community and stakeholder engagement is increasingly recognized as essential to science at the nexus of food, energy, and water systems (FEWS) to address complex issues surrounding food and energy production and water provision for society. Yet no comprehensive framework exists for supporting best practices in community and stakeholder engagement for FEWS. A review and meta‐synthesis were undertaken of a broad range of existing models, frameworks, and toolkits for community and stakeholder engagement. A framework is proposed that comprises situational awareness of the FEWS place or problem, creation of a suitable culture for engagement, focus on power‐sharing in the engagement process, …

Code Of Best Practices In Fair Use For Open Educational Resources: A Guide For Authors, Adapters & Adopters Of Openly Licensed Teaching And Learning Materials, Meredith Jacob, Peter Jaszi, Prudence S. Adler, William Cross

Copyright, Fair Use, Scholarly Communication, etc.

This code of best practices includes descriptions, hard cases, principles, and considerations for fair uses of materials in open educational resources with respect to United States copyright law, and with some discussion of copyright outside the United States context.

Open Educational Resources and Fair Use

Educators, librarians, and institutions have invested in the creation of openly licensed, freely distributed open educational resources (OER) to advance a wide range of goals within the educational system. Open educational resources enable flexible and open pedagogy; increase access to authorship and facilitate representation of different student experiences; and increase equity by reducing the barriers …

The Mitochondrial Protease Lonp1 Promotes Proteasome Inhibitor Resistance In Multiple Myeloma, Polina Iakova, Shannon E Moree, Ergun Sahin, Premal Lulla, Sarvari V Yellapragada, Francis T F Tsai, Andre Catic

Faculty, Staff and Students Publications

Multiple myeloma and its precursor plasma cell dyscrasias affect 3% of the elderly population in the US. Proteasome inhibitors are an essential part of several standard drug combinations used to treat this incurable cancer. These drugs interfere with the main pathway of protein degradation and lead to the accumulation of damaged proteins inside cells. Despite promising initial responses, multiple myeloma cells eventually become drug resistant in most patients. The biology behind relapsed/refractory multiple myeloma is complex and poorly understood. Several studies provide evidence that in addition to the proteasome, mitochondrial proteases can also contribute to protein quality control outside of …

Preliminary Evaluation Of Lespedeza Juncea Var. Sericea In South‐Western Australia, R. Snowball, T. Albertsen, K. Gajda, D. Real, Ronald Yates, B. Cohen

IGC Proceedings (1977-2023)

No abstract provided.

Methods For The Assessment Of Cell Wall Composition In Miscanthus And Other 'Energy Grasses', Mark P. Robbins, G. G. Allison, E. Hodgson, C. Morris, S. Gill, I. S. Donnison

IGC Proceedings (1977-2023)

No abstract provided.

A Wolf In Fox’S Clothing? Using Stable Isotopes To Quantify Ecological Replacement, Tyler James Clark

UM Graduate Student Research Conference (GradCon)

During the Anthropocene, human-induced extinctions, especially of large predators and herbivores, have resulted in catastrophic ecosystem collapses. Recently, conservation tools such as rewilding (e.g., re-introducing a species to its native habitat) have been used to mitigate the effects of extinction. Another increasingly popular conservation tool, ecological replacement, proposes to introduce functionally similar, non-native species to fill the ecological roles of extinct, native species, thereby restoring ecosystems towards their pre-Anthropocene state. For example, the non-native Aldabra giant tortoise was introduced to the Mauritian island of Ile aux Aigrettes to replace the ecological role of extinct Cylindraspis giant tortoises. However, the …

Quantifying The Effects Of Beaver Dam Analogs On Fish Habitat And Communities, Andrew B. Lahr

UM Graduate Student Research Conference (GradCon)

Beaver-based restoration has shown to be an effective restoration strategy for turning incised streams into complex and dynamic systems. However, there are still uncertainties regarding the pros and cons of beaver and beaver dam analogs (BDAs) as it pertains to whole system effects. Concerns focus on whether these impoundments increase temperatures beyond thermal tolerances of cold-water species, reduce stream connectivity, and exacerbate negative effects of non-native species. In order to provide more context surrounding these concerns, we began a multiyear Before-After-Control-Impact (BACI) study on three pairs of streams (one restored with BDAs and one control) across Western Montana. In each …

Quantifying Subsurface Parameter Uncertainties With Surrogate Modeling And Environmental Tracers, Nicholas E. Thiros, Payton Gardner

UM Graduate Student Research Conference (GradCon)

Identifying the uncertainty in predictions made by groundwater flow and transport numerical models is critical for effective water resource management and contaminated site remediation. In this work, we combine physics-based groundwater reactive transport modeling with data-driven machine learning techniques to quantify hydrogeologic model uncertainties for a site in Wyoming, USA. We train a deep artificial neural network (ANN) on a training dataset that consists of groundwater hydraulic head and environmental tracer concentration (³H, SF₆, and CFC-12) fields generated using a high-fidelity groundwater reactive transport model. Inputs of the training dataset and reactive transport model include variable …

Coordination Of Transboundary Marine Protected Areas In The Sulu-Sulawesi Seascape, Lindsey Ellett

UM Graduate Student Research Conference (GradCon)

Transboundary protected areas consist of clearly defined protected areas which are connected across one or more international boundaries and involve cooperation between multiple countries. The number of transboundary protected areas has experienced a dramatic increase in recent decades, and there are currently over 200 transboundary conservation initiatives worldwide. However, relatively few transboundary protected areas have been established for marine environments. Transboundary conservation approaches are integral to managing marine areas due to migratory species and issues like marine pollution and over-exploitation often crossing political boundaries. The development of transboundary marine protected areas (TBMPAs) may strengthen management and conservation by facilitating increased …

Russ College Bricks February, 16, 2021, Programs Committee

Programs Committee (PC)

No abstract provided.

The Utah Statesman, February 16, 2021, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

Skin Manifestations In Covid-19 Patients: Are They Indicators For Disease Severity? A Systematic Review, Parnian Jamshidi, Bahareh Hajikhani, Mehdi Mirsaeidi, Hassan Vahidnezhad, Masoud Dadashi, Mohammad Javad Nasiri

Department of Dermatology and Cutaneous Biology Faculty Papers

Introduction: Until now, there are several reports on cutaneous manifestations in COVID-19 patients. However, the link between skin manifestations and the severity of the disease remains debatable. We conducted a systematic review to evaluate the temporal relationship between different types of skin lesions and the severity of COVID-19. Methods: A systematic search was conducted for relevant studies published between January and July 2020 using Pubmed/Medline, Embase, and Web of knowledge. The following keywords were used: "SARS-CoV-2" or "COVID-19" or "new coronavirus" or "Wuhan Coronavirus" or "coronavirus disease 2019" and "skin disease" or "skin manifestation" or "cutaneous manifestation." Results: Out of …

Non-Transgenic Crispr-Mediated Knockout Of Entire Ergot Alkaloid Gene Clusters In Slow-Growing Asexual Polyploid Fungi, Simona Florea, Jolanta Jaromczyk, Christopher L. Schardl

Computer Science Faculty Publications

The Epichloë species of fungi include seed-borne symbionts (endophytes) of cool-season grasses that enhance plant fitness, although some also produce alkaloids that are toxic to livestock. Selected or mutated toxin-free endophytes can be introduced into forage cultivars for improved livestock performance. Long-read genome sequencing revealed clusters of ergot alkaloid biosynthesis (EAS) genes in Epichloë coenophiala strain e19 from tall fescue (Lolium arundinaceum) and Epichloë hybrida Lp1 from perennial ryegrass (Lolium perenne). The two homeologous clusters in E. coenophiala—a triploid hybrid species—were 196 kb (EAS1) and 75 kb (EAS2), and …

2021-February-16-Passing Of Dr. Brian Odle, Bill Gatton College Of Pharmacy, East Tennessee State University, University Marketing And Communication, East Tennessee State University

ETSU News

East Tennessee State University is saddened by the passing of Dr. Brian Odle, who died Monday, Feb. 15, 2021, at the age of 53.

Dr. Odle, Associate Professor of Pharmacy Practice, came to ETSU Bill Gatton College ofPharmacy in 2007. His unique teaching style combined memorable storytelling with practical knowledge. Dr. Odle was loved by his students, as well as faculty and staff.

Dr. Odle graduated from MTSU in 1990 with a degree in Biology. He then received his Doctor ofPharmacy degree from University of Tennessee, Memphis, in 1994. Dr. Odle completed a pharmacy practice residency at University of Maryland, …

Neoadjuvant Anti-Ox40 (Medi6469) Therapy In Patients With Head And Neck Squamous Cell Carcinoma Activates And Expands Antigen-Specific Tumor-Infiltrating T Cells., Rebekka Duhen, Carmen Ballesteros-Merino, Alexandra K Frye, Eric Tran, Venkatesh Rajamanickam, Shu-Ching Chang, Yoshinobu Koguchi, Carlo Bifulco, Brady Bernard, Rom Leidner, Brendan Curti, Bernard A Fox, Walter Urba, Richard Bryan Bell, Andrew D Weinberg

Articles, Abstracts, and Reports

Despite the success of checkpoint blockade in some cancer patients, there is an unmet need to improve outcomes. Targeting alternative pathways, such as costimulatory molecules (e.g. OX40, GITR, and 4-1BB), can enhance T cell immunity in tumor-bearing hosts. Here we describe the results from a phase Ib clinical trial (NCT02274155) in which 17 patients with locally advanced head and neck squamous cell carcinoma (HNSCC) received a murine anti-human OX40 agonist antibody (MEDI6469) prior to definitive surgical resection. The primary endpoint was to determine safety and feasibility of the anti-OX40 neoadjuvant treatment. The secondary objective was to assess the effect of …

Transcriptomic And Functional Analyses Of Mitochondrial Dysfunction In Pressure Overload-Induced Right Ventricular Failure, Hyuntae V Hwang, Nefthi Sandeep, Ramesh V Nair, Dong-Qing Hu, Mingming Zhao, Ingrid S Lan, Giovanni Fajardo, Scot J Matkovich, Daniel Bernstein, Sushma Reddy

Open Access Publications

Background In complex congenital heart disease patients such as those with tetralogy of Fallot, the right ventricle (RV) is subject to pressure overload, leading to RV hypertrophy and eventually RV failure. The mechanisms that promote the transition from stable RV hypertrophy to RV failure are unknown. We evaluated the role of mitochondrial bioenergetics in the development of RV failure. Methods and Results We created a murine model of RV pressure overload by pulmonary artery banding and compared with sham-operated controls. Gene expression by RNA-sequencing, oxidative stress, mitochondrial respiration, dynamics, and structure were assessed in pressure overload-induced RV failure. RV failure …

Very Low Prevalence And Incidence Of Atrial Fibrillation Among Bolivian Forager-Farmers, Christopher J. Rowan, Michael A. Eskander, Edmond Seabright, Daniel Eid Rodriguez, Edhitt Cortez Linares, Raul Quispe Gutierrez, Juan Copajira Adrian, Daniel Cummings, Bret Beheim, Kirsten Tolstrup, Abinash Achrekar, Thomas Kraft, David E. Michalik, Michael I. Miyamoto, Adel H. Allam, L. Samuel Wann, Jagat Narula, Benjamin C. Trumble, Jonathan Stieglitz, Randall C. Thompson, Gregory S. Thomas, Hillard S. Kaplan, Michael D. Gurven

ESI Publications

Background: Atrial fibrillation is the most common arrhythmia in post-industrialized populations. Older age, hypertension, obesity, chronic inflammation, and diabetes are significant atrial fibrillation risk factors, suggesting that modern urban environments may promote atrial fibrillation.

Objective: Here we assess atrial fibrillation prevalence and incidence among tropical horticulturalists of the Bolivian Amazon with high levels of physical activity, a lean diet, and minimal coronary atherosclerosis, but also high infectious disease burden and associated inflammation.

Methods: Between 2005–2019, 1314 Tsimane aged 40–94 years (52% female) and 534 Moseten Amerindians aged 40–89 years (50% female) underwent resting 12-lead electrocardiograms to assess atrial fibrillation prevalence. …

The Future Of Our Seas: Marine Scientists And Creative Professionals Collaborate For Science Communication, Laurence De Clippele*, Madlaina Michelotti, Charlotte R. Findlay, Amy Cartwright, Qing Fang, Charlie Wheatly, Ashleigh Sladen, Kes Scott-Somme, Harry R. Harding, Juliette Jackson, Laura E. Hepburn, Jessica Giannotti, Grace Carroll, Nicole Heidtke, Alison M. Worrall, Kris De Meyer

School of Biological and Marine Sciences

To increase awareness of the current challenges facing the marine environment,the Future of Our Seas (FOOS) project brought together the expertise ofscientists, public engagement experts and creatives to train and support agroup of marine scientists in effective science communication and innovativepublic engagement. This case study aims to inspire scientists and artists touse the FOOS approach in training, activity design and development support(hereafter called the ‘FOOS programme’) to collaboratively deliver noveland creative engagement activities. The authors reflect on the experiencesof the marine scientists: (1) attending the FOOS communication andengagement training; (2) creating and delivering public engagement activities;(3) understanding our audience; and …

Very Low Prevalence And Incidence Of Atrial Fibrillation Among Bolivian Forager-Farmers., Christopher J Rowan, Michael A Eskander, Edmond Seabright, Daniel Eid Rodriguez, Edhitt Cortez Linares, Raul Quispe Gutierrez, Juan Copajira Adrian, Daniel Cummings, Bret Beheim, Kirsten Tolstrup, Abinash Achrekar, Thomas Kraft, David E Michalik, Michael Miyamoto, Adel H Allam, L Samuel Wann, Jagat Narula, Benjamin C Trumble, Jonathan Stieglitz, Randall C Thompson, Gregory S Thomas, Hillard S Kaplan, Michael D Gurven

Articles, Abstracts, and Reports

Background: Atrial fibrillation is the most common arrhythmia in post-industrialized populations. Older age, hypertension, obesity, chronic inflammation, and diabetes are significant atrial fibrillation risk factors, suggesting that modern urban environments may promote atrial fibrillation.

Objective: Here we assess atrial fibrillation prevalence and incidence among tropical horticulturalists of the Bolivian Amazon with high levels of physical activity, a lean diet, and minimal coronary atherosclerosis, but also high infectious disease burden and associated inflammation.

Methods: Between 2005-2019, 1314 Tsimane aged 40-94 years (52% female) and 534 Moseten Amerindians aged 40-89 years (50% female) underwent resting 12-lead electrocardiograms to assess atrial fibrillation prevalence. …

Gene Expression Barcode Values Reveal A Potential Link Between Parkinson's Disease And Gastric Cancer, Suyan Tian, Shishun Zhao, Mingbo Tang, Chi Wang

Internal Medicine Faculty Publications

Gastric cancer is a disease that develops from the lining of the stomach, whereas Parkinson's disease is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. Although these two diseases seem to be distinct from each other, increasing evidence suggests that they might be linked. To explore the linkage between these two diseases, differentially expressed genes between the diseased people and their normal controls were identified using the barcode algorithm. This algorithm transforms actual gene expression values into barcode values comprised of 1's (expressed genes) and 0's (silenced genes). Once the overlapped differentially expressed …

P53 Is Potentially Regulated By Cyclophilin D In The Triple-Proline Loop Of The Dna Binding Domain, Jacques Kumutima, Xin-Qiu Joe Yao, Donald Hamelberg

Chemistry Faculty Publications

The multifunctional protein p53 is the central molecular sensor of cellular stresses. The canonical function of p53 is to transcriptionally activate target genes in response to, for example, DNA damage that may trigger apoptosis. Recently, p53 was also found to play a role in the regulation of necrosis, another type of cell death featured by the mitochondrial permeability transition (mPT). In this process, p53 directly interacts with the mPT regulator cyclophilin D, the detailed mechanism of which however remains poorly understood. Here, we report a comprehensive computational investigation of the p53–cyclophilin D interaction using molecular dynamics simulations and associated analyses. …

The Genomics Of Ecological Flexibility, Large Brains, And Long Lives In Capuchin Monkeys Revealed With Fecalfacs., Joseph D Orkin, Michael J Montague, Daniela Tejada-Martinez, Marc De Manuel, Javier Del Campo, Saul Cheves Hernandez, Anthony Di Fiore, Claudia Fontsere, Jason A Hodgson, Mareike C Janiak, Lukas F K Kuderna, Esther Lizano, Maria Pia Martin, Yoshihito Niimura, George H Perry, Carmen Soto Valverde, Jia Tang, Wesley C Warren, João Pedro De Magalhães, Shoji Kawamura, Tomàs Marquès-Bonet, Roman Krawetz, Amanda D Melin

Department of Biochemistry and Molecular Biology Faculty Papers

Ecological flexibility, extended lifespans, and large brains have long intrigued evolutionary biologists, and comparative genomics offers an efficient and effective tool for generating new insights into the evolution of such traits. Studies of capuchin monkeys are particularly well situated to shed light on the selective pressures and genetic underpinnings of local adaptation to diverse habitats, longevity, and brain development. Distributed widely across Central and South America, they are inventive and extractive foragers, known for their sensorimotor intelligence. Capuchins have among the largest relative brain size of any monkey and a lifespan that exceeds 50 y, despite their small (3 to …

Bricks Language For Undergraduate Catalog, February 16, 2021, General Education Committee

General Education Committee

No abstract provided.

Covid-19 Newsletter (Vol. 59), Center For Disaster Medicine, New York Medical College

COVID-19 Newsletter

No abstract provided.

Antimicrobial Resistance And Covid-19: Intersections And Implications, Gwenan M. Knight, Rebecca E. Glover, C Finn Mcquaid, Ioana D. Olaru, Karin Gallandat, Quentin J. Leclerc, Naomi M. Fuller, Sam J. Willcocks, Rumina Hasan, Esther Van Kleef, Clare Ir Chandler

Department of Pathology and Laboratory Medicine

Before the coronavirus 2019 (COVID-19) pandemic began, antimicrobial resistance (AMR) was among the top priorities for global public health. Already a complex challenge, AMR now needs to be addressed in a changing healthcare landscape. Here, we analyse how changes due to COVID-19 in terms of antimicrobial usage, infection prevention, and health systems affect the emergence, transmission, and burden of AMR. Increased hand hygiene, decreased international travel, and decreased elective hospital procedures may reduce AMR pathogen selection and spread in the short term. However, the opposite effects may be seen if antibiotics are more widely used as standard healthcare pathways break …

Writing Retreat Goes Digital, Lily Greenberg

UNH Today Archive

No abstract provided.

State V. Sedillo Appellant's Brief Dckt. 48127

Not Reported

No abstract provided.

Investigating The Recent History Of A Changing Planet With Innovative Isotopic Techniques And New Geologic Archives, Ryan A. Venturelli

USF Tampa Graduate Theses and Dissertations

Globally averaged Earth surface temperatures indicate a 0.8°C warming since 1880. Though this warming is a result of anthropogenic influence that has exceeded natural forcings, a thorough understanding of Earth's climate system requires a knowledge of changes in global temperatures beyond the instrumental record. To achieve this, we must supplement the temporally limited observational record with proxy records of environmental conditions in the geologic past. Though the foundational questions underlying interrogations of the geologic past are seemingly simple (What happened? When?), the accuracy of their answers depend upon accessibility and availability of geologic materials as well as the capabilities of …

Sex Differences In Μ-Opioid Regulation Of Coerulear-Cortical Transmission, Herminio M. Guajardo, Rita J. Valentino

Health & Biomedical Sciences Faculty Publications

Stress-induced activation of locus coeruleus (LC)-norepinephrine (NE) projections to the prefrontal cortex are thought to promote cognitive responses to stressors. LC activation by stressors is modulated by endogenous opioids that restrain LC activation and facilitate a return to baseline activity upon stress termination. Sex differences in this opioid influence could be a basis for sex differences in stress vulnerability. Consistent with this, we recently demonstrated that μ-opioid receptor (MOR) expression is decreased in the female rat LC compared to the male LC, and this was associated with sexually distinct consequences of activating MOR in the LC on cognitive flexibility. Given …

An Ecotoxicological Approach To Microplastics On Terrestrial And Aquatic Organisms: A Systematic Review In Assessment, Monitoring And Biological Impact, Omar A. Vazquez, Saydur Rahman

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Marine and land plastic debris biodegrades at micro- and nanoscales through progressive fragmentation. Oceanographic model studies confirm the presence of up to ~2.41 million tons of microplastics across the Atlantic, Pacific, and Indian subtropical gyres. Microplastics distribute from primary (e.g., exfoliating cleansers) and secondary (e.g., chemical deterioration) sources in the environment. This anthropogenic phenomenon poses a threat to the flora and fauna of terrestrial and aquatic ecosystems as ingestion and entanglement cases increase over time. This review focuses on the impact of microplastics across taxa at suggested environmentally relevant concentrations, and advances the groundwork for future ecotoxicological-based research on microplastics …